Search Our Scientific Publications & Authors

Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN.

Objectives: Little is known about frailty that develops following critical illness. We sought to describe the prevalence of newly acquired frailty, its clinical course, and the co-occurrence of frailty with disability and cognitive impairment in survivors of critical illness.

Design: Longitudinal prospective cohort study. Read More

PLoS One 2020 2;15(7):e0235570. Epub 2020 Jul 2.

Psychology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Montescano Institute, Pavia, Italy.

Background: The association among psychological, neuropsychological dysfunctions and functional/clinical variables in Chronic Heart Failure (CHF) has been extensively addressed in literature. However, only a few studies investigated those associations in the older population.

Purpose: To evaluate the psychological/neuropsychological profile of older CHF patients, to explore the interrelation with clinical/functional variables and to identify potential independent predictors of patients' functional status. Read More

SAGE Open Med 2020 20;8:2050312120933804. Epub 2020 Jun 20.

Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy.

Nonalcoholic fatty liver disease is increasingly recognized as a major global health problem. Intertwined with diabetes, metabolic syndrome, and obesity, nonalcoholic fatty liver disease embraces a spectrum of liver conditions spanning from steatosis to inflammation, fibrosis, and liver failure. Compared with the general population, the prevalence of cardiovascular disease is higher among nonalcoholic fatty liver disease patients, in whom comprehensive cardiovascular risk assessment is highly desirable. Read More

BMC Public Health 2020 Jul 1;20(1):1042. Epub 2020 Jul 1.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: A declining trend in mean cholesterol levels and smoking has been observed in high-income western countries during the last few decades, whereas obesity rates have increased. Simultaneously, mortality from coronary heart disease has decreased. The aim of the present study was to determine whether the trends in cardiovascular risk factors have continued in successive cohorts of middle-aged women over a period of 34 years. Read More

Nutrients 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Rehabilitation Medicine, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga, Tochigi 3210293, Japan.

Previous studies have suggested that the nutritional status after stroke is independently associated with long-term outcomes and that sarcopenia delays poststroke rehabilitation and worsens the prognosis. However, many stroke patients have a deteriorated nutritional status and a decreased muscle mass in the acute phase. This prospective study included 179 patients who were admitted to the stroke rehabilitation unit. Read More

J Card Fail 2020 Jun 27. Epub 2020 Jun 27.

Chair, Section of Geriatric Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania; Division of Cardiology, Washington University School of Medicine, Saint Louis, Missouri.. Electronic address:

J Pain 2020 Jun 26. Epub 2020 Jun 26.

Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA.

This cross-sectional study examines the association between chronic musculoskeletal pain and foot reaction time (RT) among older community-living adults. Participants were 307 adults aged 71 years and older in the MOBILIZE Boston Study II. Pain severity, interference, and location were measured by the Brief Pain Inventory and a joint pain questionnaire. Read More

J Telemed Telecare 2020 Jun 28:1357633X20932434. Epub 2020 Jun 28.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong.

Introduction: This study aimed to investigate the effects of a home-based occupational therapy telerehabilitation (TR) via smartphone in enhancing functional and motor performance and fall efficacy for outpatients receiving day hospital rehabilitation after hip fracture surgery in Hong Kong.

Methods: This was a feasibility randomised controlled trial with two groups - an experimental group and a comparison group - and a sample of 31 older adults attending a geriatric day hospital who had undergone hip fracture surgery within 12 weeks of diagnosis. Patients were assessed at baseline, immediately after a three-week intervention and at three-week post-intervention follow-up for motor performance, activities of daily living (ADL) functioning and fall efficacy. Read More

Adv Gerontol 2020 ;33(2):331-338

Smolensk State Medical University, 28 Krupskaya Str., Smolensk 214019, Russian Federation, e-mail:

We studied the prevalence of chronic non-communicable diseases (CND) in elderly and senile patients in conjunction with the syndrome of senile asthenia, the prevalence of sarcopenia depending on gender characteristics and the frequency of occurrence of the falls syndrome in patients with sarcopenia of older age groups. The features of drug therapy in outpatient practice were analyzed. The method of complex geriatric assessment was used in 528 patients divided into 3 age groups (65-74 years, 75-84 years, 85 years or more). Read More

Phys Ther 2020 Jun 26. Epub 2020 Jun 26.

Rehabilitation Physical Therapist, Shoham Geriatric Medical Center.

J Gerontol A Biol Sci Med Sci 2020 Jun 26. Epub 2020 Jun 26.

Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, Ohio.

Background: Weakness is a risk factor for physical limitations and death in older adults (OAs). We sought to determine whether OAs with clinically meaningful leg extensor weakness exhibit differences in voluntary inactivation (VIA) and measures of corticospinal excitability when compared to young adults (YAs) and OAs without clinically meaningful weakness. We also sought to estimate the relative contribution of indices of neural excitability and thigh lean mass in explaining the between-subject variability in OAs leg extensor strength. Read More

Gerontol Geriatr Med 2020 Jan-Dec;6:2333721420924952. Epub 2020 Jun 12.

Division of General Medicine and Geriatrics, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Social engagement and autonomy are vital for life satisfaction among older adults. We measured multiple domains of social participation and autonomy in 120 adults over age 55 years that were part of an educational program at pretest, posttest, and follow-up. Quantitative and qualitative data were analyzed for differences between Black and White participants. Read More

Stroke 2020 Jun 26:STROKEAHA120029468. Epub 2020 Jun 26.

Department of Statistics, Umeå School of Business, Economics and Statistics, Umeå University, Sweden. (M.E.).

Background And Purpose: Intravenous thrombolysis is a well-established treatment for acute ischemic stroke. Our aim was to quantify the effect of each minute delay in door-to-needle time (DNT) on 90-day survival, intracerebral hemorrhagic complication <36 hours, and functional outcomes at 3 months, in routine clinical practice.

Methods: Our nationwide registry-based study included 14 132 adult patient admissions with ischemic stroke receiving intravenous thrombolysis from 2010 to 2017. Read More

Psychiatry Res Neuroimaging 2020 Jun 15;303:111129. Epub 2020 Jun 15.

Research Center for Child Mental Development, University of Fukui, Fukui, Japan; Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, Japan; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, Japan. Electronic address:

Childhood maltreatment is associated with altered brain structure and function and is a major risk factor for psychopathology, including reactive attachment disorder (RAD). However, whether changes to white matter microstructural integrity are associated with RAD is unclear. We used diffusion tensor imaging (DTI) to assess group differences in fractional anisotropy (FA) in patients with RAD (n = 25; mean age = 13. Read More

Age Ageing 2020 Jun 25. Epub 2020 Jun 25.

AGE Research Group, Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL; NIHR Newcastle Biomedical Research Centre, Faculty of Medical Sciences, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust.

Older people are disproportionately affected by the COVID-19 pandemic, which has had a profound impact on research as well as clinical service delivery. This commentary identifies key challenges and opportunities in continuing to conduct research with and for older people, both during and after the current pandemic. It shares opinions from responders to an international survey, a range of academic authors and opinions from specialist societies. Read More

PLoS One 2020 25;15(6):e0234904. Epub 2020 Jun 25.

Department of Geriatric Care, Orthogeriatrics and Rehabilitation, EO Galliera Hospital, Genova, Italy.

Background: Falls in the elderly are a major public health concern because of their high incidence, the involvement of many risk factors, the considerable post-fall morbidity and mortality, and the health-related and social costs. Given that many falls are preventable, the early identification of older adults at risk of falling is crucial in order to develop tailored interventions to prevent such falls. To date, however, the fall-risk assessment tools currently used in the elderly have not shown sufficiently high predictive validity to distinguish between subjects at high and low fall risk. Read More

Int J Palliat Nurs 2020 Jun;26(5):238-245

Professor of Elderly Care Medicine, Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands.

Background: Post-acute rehabiitation is recommended in the treatment of chronic obstructive pulmonary disease (COPD). It enhances the sense of control by education, which should focus on patient information needs. However, it is unknown whether a geriatric rehabilitation programme for older patients with advanced COPD and severely impaired health status (the GR-COPD programme) does fit these patient information needs. Read More

Rev Invest Clin 2020 ;72(3):127-134

Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: The coronavirus disease 2019 (COVID-19) has been declared a global pandemic. Older adults have been found as a vulnerable group for developing severe forms of disease and increased mortality.

Objective: The objective of the study was to propose a pathway to assist the decision-making process for hospital resource allocation for older adults with COVID-19 using simple geriatric assessment-based tools. Read More

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Background And Purpose: The group of genetic degenerative ataxias shares the same feature of gradual deterioration in balance and coordination. However, no cure is yet available for this group of disorders, while rehabilitation remains a cornerstone in the current therapy. This review aims to present a summary of the current knowledge of balance and coordination training in patients with inherited degenerative ataxia and to discuss the training effectiveness accordingly. Read More

Swiss Med Wkly 2020 Jun 17;150:w20276. Epub 2020 Jun 17.

Department of Geriatrics, University Hospital Zurich, Switzerland / Centre on Aging and Mobility, University of Zurich, Switzerland.

Aims Of The Study: Post-acute care (PAC) is intended for older adult patients who are unable to return home directly after acute hospitalisation but who do not otherwise qualify for specific rehabilitation. However, data on potential predictors of PAC outcomes remain limited. Our aim was to identify patient characteristics upon admission to PAC that are associated with subsequent institutionalisation. Read More

Geriatr Orthop Surg Rehabil 2020 11;11:2151459320931674. Epub 2020 Jun 11.

Department of Orthopaedic Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA.

Introduction: Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) and Portsmouth POSSUM (P-POSSUM) are general surgical tools used to efficiently assess mortality and morbidity risk. Data suggest that these tools can be used in hip fracture patients to predict morbidity and mortality; however, it is unclear what score indicates a significant risk on a case-by-case basis. We examined the POSSUM and P-POSSUM scores in a group of hip fracture mortalities in order to assess their accuracy in identification of similar high-risk patients. Read More

J Am Med Dir Assoc 2020 Jun 20. Epub 2020 Jun 20.

Geriatric Medicine and Palliative Care, Khoo Teck Puat Hospital, Singapore.

Objectives: We examined the demographics and the clinical profile of teleconsultations conducted between an acute geriatric medicine department and 8 nursing homes over a period of 6.5 years.

Design: This is a prospective, descriptive study. Read More

Eur J Neurosci 2020 Jun 23. Epub 2020 Jun 23.

Hertie Institute for Clinical Brain Research (HIH), Department of Cognitive Neurology, University of Tübingen, Otfried-Müller-Str. 27, 72076, Tübingen, Germany.

By 2050, the global population of people aged 65 years or older will triple. While this is accompanied with an increasing burden of age-associated diseases, it also emphasizes the need to understand the effects of healthy ageing on cognitive processes. One such effect is a general slowing of processing speed, which is well documented in many domains. Read More

J Am Med Dir Assoc 2020 May 25. Epub 2020 May 25.

Geriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; Department of Medicine and Surgey, University of Parma, Parma, Italy.

Objective: Bedside chest ultrasonography, when integrated with clinical data, is an accurate tool for improving the diagnostic process of many respiratory diseases. This study aims to evaluate the feasibility of a chest ultrasonographic screening program in nursing homes for detecting coronavirus disease-19 (COVID-19)-related pneumonia and improving the appropriateness of hospital referral of residents.

Design: Pragmatic, descriptive, feasibility study from April 2 to April 9, 2020. Read More

Respiration 2020 Jun 22:1-8. Epub 2020 Jun 22.

Geriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy,

Background: Lung ultrasound (LUS) is an accurate, safe, and cheap tool assisting in the diagnosis of several acute respiratory diseases. The diagnostic value of LUS in the workup of coronavirus disease-19 (COVID-19) in the hospital setting is still uncertain.

Objectives: The aim of this observational study was to explore correlations of the LUS appearance of COVID-19-related pneumonia with CT findings. Read More

J Vis Exp 2020 Jun 3(160). Epub 2020 Jun 3.

Department of Neurology and Neuropathology, Golgi-Cenci Foundation; Laboratory of Neurobiology and Neurogenetic, Golgi-Cenci Foundation; Department of Neuropsychology and Social Sciences, Golgi-Cenci Foundation.

In a constantly aging population, the prevalence of neurodegenerative disorders is expected to rise. Understanding disease mechanisms is the key to find preventive and curative measures. The most effective way to achieve this is through direct examination of diseased and healthy brain tissue. Read More

Am J Health Promot 2020 Jun 22:890117120934622. Epub 2020 Jun 22.

University of Vermont Center on Aging, Burlington, VT, USA.

Rural communities need access to effective interventions that can prevent functional decline among a growing population of older adults. We describe the conceptual framework and rationale for a multicomponent intervention ("Mind, Mood, Mobility") delivered by Area Agency on Aging staff for rural older adults at risk for functional decline due to early impairments in cognition, mood, or mobility. Our proposed model utilizes primary care to identify at-risk older adults, combines evidence-based interventions that address multiple risk factors simultaneously, and leverages a community-based aging services workforce for intervention delivery. Read More

Acta Neurol Belg 2020 Jun 21. Epub 2020 Jun 21.

Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Social media is a powerful tool in providing information and support for minority groups such as patients with chronic diseases. We aimed to assess the link between using online social media and depression in a sample population of Iranian Multiple Sclerosis (MS) patients. In this cross-sectional study, a number of MS patients between 18-55 years were recruited. Read More

EClinicalMedicine 2020 Jun 15;23:100411. Epub 2020 Jun 15.

Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

Background: Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary method to identify geriatric conditions among older patients. The aim of the present study was to examine the associations between CGA and short-term outcomes among older adult inpatients with stroke.

Methods: The study was a nationwide, retrospective cohort study. Read More

Ageing Res Rev 2020 Jun 18;62:101118. Epub 2020 Jun 18.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.

Vaccination is the main public health intervention to prevent influenza. We aimed to evaluate the efficacy and safety of influenza vaccination including systematic reviews and meta-analyses of observational studies and randomized controlled trials (RCTs). Peer-reviewed systematic reviews with meta-analyses of prospective studies that investigated the association of influenza vaccination with any health-related outcome, as well as RCTs that investigated the efficacy and safety of influenza vaccination, were included. Read More

J Am Med Dir Assoc 2020 Jun 18. Epub 2020 Jun 18.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Allied Health Professionals, Function Area Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

Objectives: The First-time Injurious Fall (FIF) screening tool was created to identify fall risk in community-living older adults who may benefit from primary preventive interventions. The aim of this study was to evaluate the predictive performance of the FIF tool in 2 cohorts of older adults.

Design: Longitudinal cohort study. Read More

Histol Histopathol 2020 Jun 18:18235. Epub 2020 Jun 18.

Department of Geriatric Medicine, Tokyo Medical University, Nishishinjuku, Shinjuku-ku, Tokyo, Japan.

The transactivation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein pivotal in RNA processing. Because phosphorylated TDP43 (pTDP-43) has been identified as a component of the ubiquitin-positive and tau-negative inclusions observed in the brains of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients, it is considered to play a major role in neurodegenerative processes. We previously reported that pTDP-43 is located in macrophages of atherosclerotic lesions of human carotid and major cerebral arteries. Read More

Rev Saude Publica 2020 12;54:56. Epub 2020 Jun 12.

Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil.

Objective: To evaluate the incidence and persistence of fear of falling in older adults and the clinical/functional, psychosocial and lifestyle-related risk factors.

Methods: A longitudinal study with 393 community-dwelling older adults aged 65 years and over (110 men/ 283 women) resident in the North Zone of the city of Rio de Janeiro, Brazil. The fear of falling was assessed by the Falls Efficacy Scale-I-BR. Read More

Geriatr Psychol Neuropsychiatr Vieil 2020 Jun;18(2):125-133

CHU de Nice, Président de la Société Française de Gériatrie et Gérontologie, France.

The COVID-19 epidemic that started in November in China became a national epidemic from March 16, 2020 with the declaration of population containment in order to reduce the spread of the virus in France. From March 17 to March 27, 2020, the monitoring unit of the French society of geriatrics and gerontology decided to conduct a survey to analyze the implementation of the mobilization of geriatric units, given that this epidemic had shown that it resulted in excess mortality mainly among the elderly. The survey was able to bring together the response of 34 services, nine of which were located in a high epidemic cluster zone. Read More

HERD 2020 Jun 18:1937586720922852. Epub 2020 Jun 18.

College of Design, Construction and Planning, University of Florida, Gainesville, FL, USA.

Objectives: To evaluate the diffusion of multisensory environments (MSEs) as an innovation at the Veterans Health Administration (VHA) and gather feedback regarding staff perceptions of barriers to uptake and effectiveness of MSEs for Veterans with dementia.

Background: Responding to the need for nonpharmacological behavioral interventions, VHA funded the first MSE for Veterans with dementia in 2010. The room incorporated LED color-changing lights, bubble tubes, vibroacoustic furniture, music, and aromatherapy, and the success of this patient-centered sensory room fueled national rollouts in 2013 and 2015. Read More

BMJ Open 2020 Jun 15;10(6):e036221. Epub 2020 Jun 15.

School of Medicine, Division of Medical Science and Graduate Entry Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK

Introduction: Older people who live in care homes have a high level of need with complex health conditions. In addition to providing medical care to residents, general practitioners (GPs) play a role as gatekeeper for access to services, as well as leadership within healthcare provision. This review will describe how GPs were involved in initiatives to change arrangements of healthcare services in order to improve quality and experience of care. Read More

BMJ Open 2020 Jun 15;10(6):e035508. Epub 2020 Jun 15.

Scientific Direction, IRCCS INRCA, Ancona, Italy

Introduction: Deficits in balance and walking ability are relevant risk factors for falls during ageing. Moreover, falls are a risk factor for future falls, strongly associated with adverse health outcomes, such as fear of falling or fractures, particularly, hip fracture. For this reason, the development of prevention tools and innovative rehabilitation strategies is one of the main objectives in geriatrics. Read More

Diagnostics (Basel) 2020 Jun 12;10(6). Epub 2020 Jun 12.

Community and Geriatric Medicine Research Center, National Taiwan University Hospital, Bei-Hu Branch, Taipei 108, Taiwan.

(1) Background: Dynapenia is defined as lower muscle strength alone. Only a few studies have investigated muscle quality in subjects with dynapenia. (2) Methods: The muscle quality, characterized by texture parameters of biceps brachii, triceps brachii, rectus femoris, and medial gastrocnemius muscles, were collected using ultrasonography. Read More

JMIR Mhealth Uhealth 2020 Jun 14. Epub 2020 Jun 14.

The Dartmouth Institute for Health Policy, Dartmouth, 1 Medical DriveWilliamson Translational Research Building, Level 5, Lebanon, US.

Background: Sarcopenia, defined as the age-associated loss of muscle mass and strength, can be effectively mitigated through resistance-based physical activity. With compliance at ~40% for home-based exercise prescriptions, implementing a remote-sensing system would help patients and clinicians understand treatment progress and increase compliance. Inclusion of end users in the development of mobile applications for remote sensing systems can ensure that they are both user-friendly and facilitate compliance. Read More

Aging Clin Exp Res 2020 Jun 14. Epub 2020 Jun 14.

Institute of Human Movement Science, University of Hamburg, Mollerstraße 10, 20148, Hamburg, Germany.

Background: A multi-component training program holds promises for the elderly, but still has to be tested on its feasibility and effect in nursing homes.

Aims: The aim of this study was (1) to design a multi-component training program which improves physical functioning and psychosocial wellbeing and (2) to evaluate the feasibility of this intervention in nursing home residents.

Methods: This study is a two-arm, stratified-randomized controlled feasibility trail. Read More

Geriatr Orthop Surg Rehabil 2020 2;11:2151459320930554. Epub 2020 Jun 2.

Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, VA, USA.

Background: The novel coronavirus disease (COVID-19) has afflicted millions of people worldwide since its first case was reported in December 2019. Personal protective equipment (PPE) has been tailored accordingly, but as of April 2020, close to 10 000 health care workers in the United States have contracted COVID-19 despite wearing recommended PPE. As such, standard guidelines for PPE may be inadequate for the health care worker performing high-risk aerosolizing procedures such as endotracheal intubation. Read More

Arch Gerontol Geriatr 2020 May 23;90:104125. Epub 2020 May 23.

Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

Background And Purpose: The revised European Working Group on Sarcopenia in Older People (EWGSOP2, version 2019) definition of sarcopenia differs with respect to the EWGSOP (version 2010) definition in applied criteria and their cut-off values. We aimed to investigate the impact of the new definition on sarcopenia prevalence in various populations of older adults.

Methods: Eight cohorts, including community-dwelling older adults, geriatric outpatients and patients admitted to acute and subacute inpatient wards were assessed on sarcopenia prevalence. Read More

J Periodontol 2020 Jun 13. Epub 2020 Jun 13.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, GH Sergievsky Center, New York, NY, USA.

Background: There is a sparsity of data describing the periodontal microbiome in elderly individuals. We analyzed the association of subgingival bacterial profiles and clinical periodontal status in a cohort of participants in the Washington Heights-Inwood Columbia Aging Project (WHICAP).

Methods: Dentate individuals underwent a full-mouth periodontal examination at 6 sites/tooth. Read More

BMJ Open 2020 Jun 11;10(6):e035850. Epub 2020 Jun 11.

Stroke, Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia

Objectives: Information about younger people of working age (≤65 years), their post stroke outcomes and rehabilitation pathways can highlight areas for further research and service change. This paper describes: (1) baseline demographics; (2) post acute rehabilitation pathways; and (3) 12-month outcomes; disability, mobility, depression, quality of life, informal care and return to work of working age people across three geographic regions (Australasia (AUS), South East (SE) Asia and UK).

Design: This post hoc descriptive exploration of data from the large international very early rehabilitation trial (A Very Early Rehabilitation Trial (AVERT)) examined the four common post acute rehabilitation pathways (inpatient rehabilitation, home with community rehabilitation, inpatient rehabilitation then community rehabilitation and home with no rehabilitation) experienced by participants in the 3 months post stroke and describes their 12-month outcomes. Read More

Alzheimer Dis Assoc Disord 2020 Jun 10. Epub 2020 Jun 10.

Department of Internal Medicine, Division of Geriatric Medicine, Hacettepe University Faculty of Medicine.

Background: Cutoff values of cognitive screen tests vary according to age and educational levels.

Objective: The objective of this study was to compare the accuracy and determine cutoffs for 3 short cognitive screening instruments: the Mini-Mental State Examination, Montreal Cognitive Assessment (MoCA), and Quick Mild Cognitive Impairment Screen-Turkish version (Qmci-TR), in older adults with low literacy in Turkey.

Methods: In all 321 patients, 133 with subjective cognitive complaints (SCC), 88 amnestic-type mild cognitive impairment (aMCI), and 100 with probable Alzheimer disease (AD) with a median of 5 years education were included. Read More

Disabil Rehabil 2020 Jun 12:1-9. Epub 2020 Jun 12.

Department of Physiotherapy and Occupational Therapy, Copenhagen University Hospital, Herlev and Gentofte, Hellerup, Denmark.

The de Morton Mobility Index (DEMMI) is a unidimensional clinical instrument proven reliable and valid for measuring mobility in the elderly, but its responsiveness has not been evaluated when applying the methodology recommended by COSMIN. To evaluate the responsiveness and the predictive validity of the DEMMI. Elderly people, referred for municipality-based rehabilitation, were consecutively included. Read More

Front Aging Neurosci 2020 21;12:143. Epub 2020 May 21.

Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.

Studies have shown that excess formaldehyde accumulation in the brain accelerates cognitive decline in people with Alzheimer's disease (AD). Recently, reports from our research team revealed that red light treatment (RLT) improved memory in AD mice by activating formaldehyde dehydrogenase (FDH) and thus reducing formaldehyde levels. Here, we developed a medical RLT device to investigate the safety and efficacy of this device in older adults with mild to moderate AD. Read More

PLoS Med 2020 Jun 11;17(6):e1003135. Epub 2020 Jun 11.

Unit of Geriatric Medicine, Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden.

Background: In individuals below 65 years of age, primary prevention programs have not been successful in reducing the risk of cardiovascular disease (CVD) and death. However, no large study to our knowledge has previously evaluated the effects of prevention programs in individuals aged 65 years or older. The present cohort study evaluated the risk of CVD in a primary prevention program for community-dwelling 70-year-olds. Read More

Arch Gerontol Geriatr 2020 May 29;90:104128. Epub 2020 May 29.

Department of Health and Rehabilitation Sciences, Prince Sattam Bin Abdulaziz University, Saudi Arabia.

Background: Frailty is a common geriatric syndrome that can be screened using validated questionnaires. A commonly used assessment is the Tilburg Frailty Indicator (TFI), containing fifteen self-reported questions about components of frailty, with scores ranging from zero to fifteen (higher scores representing increased frailty and a cutoff score of greater than five used to diagnose frailty). Despite its widespread use, the TFI is not commonly used in Arabic-speaking countries, and there is an overall lack of Arabic-translated questionnaires to adequately detect and measure frailty for older adults in Saudi Arabia. Read More

Lymphology 2020 ;53(1):20-28

MAGI Euregio, Bolzano, BZ (headquarters); San Felice del Benaco (branch), Italy.

CYP26B1 is a member of the cytochrome P450 family and is responsible for the break-down of retinoic acid for which appropriate levels are important for normal development of the cardiovascular and lymphatic systems. In a cohort of 235 patients with lymphatic malformations, we performed genetic testing for the CYP26B1 gene. These probands had previously tested negative for known lymphedema genes. Read More