97,256 results match your criteria Geriatric Nursing[Journal]


Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.

Dement Geriatr Cogn Disord 2018 Dec 6;46(5-6):346-357. Epub 2018 Dec 6.

Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.

Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More

View Article
December 2018
2 Reads

Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease.

PLoS One 2018 6;13(12):e0207843. Epub 2018 Dec 6.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Aims: To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.

Methods: We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Read More

View Article
December 2018

Treatment outcomes of pancreatic cancer in the elderly - literature review.

Folia Med Cracov 2018 ;58(3):49-66

3rd Department of General, Oncological and Geriatric Surgery of Jagiellonian University School of Medicine, Prądnicka 35-37, Kraków, Poland.

Background: The older population is very heterogeneous with regard to the co-morbidityand the physical reserve. This can result in unacceptably high postoperative complications rates. Therefore, the aim of the study was to review the literature regarding the outcomes of older patients treated for pancreatic cancer, including the usage of minimal invasive techniques. Read More

View Article
January 2018

Psychosis in neurodegenerative disorders: recent developments.

Curr Opin Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital.

Purpose Of Review: This review presents the latest developments covered in the literature regarding psychosis in neurodegenerative disorders and discusses possible future research directions.

Recent Findings: Recent findings in the field of psychosis and neurodegenerative disorders revolve around four main themes. The first theme is the impact of sex on the expression of psychosis in neurodegenerative disorders. Read More

View Article
December 2018

Effect of blast-related mTBI on the working memory system: a resting state fMRI study.

Brain Imaging Behav 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA.

Reduced working memory is frequently reported by Veterans with a history of blast-related mild traumatic brain injury (mTBI), but can be difficult to quantify on neuropsychological measures. This study aimed to improve our understanding of the impact of blast-related mTBI on the working memory system by using resting state functional magnetic resonance imaging (fMRI) to explore differences in functional connectivity between OEF/OIF/OND Veterans with and without a history of mTBI. Participants were twenty-four Veterans with a history of blast-related mTBI and 17 Veterans who were deployed but had no lifetime history of TBI. Read More

View Article
December 2018
5 Reads

The Finnish Interprofessional Medication Assessment (FIMA): baseline findings from home care setting.

Aging Clin Exp Res 2018 Dec 5. Epub 2018 Dec 5.

Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Purpose: Medication-related problems and declined functional capacity are closely associated factors among older people. The purpose of this study is to describe the procedure of interprofessional medication assessment in home care context and the baseline characteristics of the study population.

Methods: The FIMA study was a randomized, controlled intervention study comparing general practitioner-led interprofessional medication assessment and usual care. Read More

View Article
December 2018

Discrepancy Between Equations Estimating Kidney Function in Geriatric Care: A Study of Implications for Drug Prescription.

Drugs Aging 2018 Dec 6. Epub 2018 Dec 6.

CHU Bordeaux, Département de Gérontologie Clinique, Avenue du Haut-Lévêque, F-33604, Pessac, France.

Background: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFR). The implications of these discrepancies for drug prescription have so far been assessed only for a few selected molecules.

Objective: The aim of this study was to investigate the proportion of geriatric patients receiving drugs with a different recommended dose or indication (i. Read More

View Article
December 2018

L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, China.

Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in adipose tissue SASP and dysfunction. Read More

View Article
December 2018

The past decade in type 2 diabetes and future challenges.

Hormones (Athens) 2018 Dec 5. Epub 2018 Dec 5.

Department of Geriatric Medicine, Princess Royal University Hospital, King's College Hospital NHS Foundation Trust, 6B Durham Road, Bromley, London, BR2 0SG, UK.

There is today an exponential increase in prevalence of type 2 diabetes mellitus (T2DM), especially in young people. This downward shift in age of onset of T2DM has been shown by abundant evidence to be due to an increase in obesity among the young, the latter mainly attributable to unhealthy dietary habits and a sedentary lifestyle. It is therefore obvious that the prevention of diabetes rather its treatment is of is paramount importance. Read More

View Article
December 2018

Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease.

Mol Neurobiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.

The canonical Wnt pathway is critical for both the development and adulthood survival and homeostatic maintenance of the midbrain dopaminergic (DA) neurons. Expanding evidence has demonstrated that genetic factors associated with familial Parkinson disease (PD) deregulate this important pathway, suggesting that a disturbed canonical Wnt pathway is likely involved in PD pathogenesis; yet, the specific role of this pathway in sporadic PD remains unclear. In this study, we aimed to determine the effects of specific inhibition of the canonical pathway by hemizygous knockout of β-catenin, the obligatory component of the canonical Wnt pathway, on paraquat (PQ)-induced DA neuronal degeneration in the substantia nigra in vivo. Read More

View Article
December 2018

Continuous improvement process: ortho-geriatric co-management of proximal femoral fractures.

Arch Orthop Trauma Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic and Trauma Surgery, Robert-Bosch-Krankenhaus Stuttgart, Auerbachstrasse 110, 70376, Stuttgart, Germany.

Objective: The objective of the current study was to evaluate the effect of a quality management system on treatment and care delivery of proximal femoral fractures. Specifically, our hypothesis was that the "plan-do-check-act (PDCA)" philosophy of the ISO 9001 quality management system results in a continuous improvement process.

Methods: 1015 proximal femoral fractures were prospectively included into a hip fracture database over a 5-year period, after a restructuring process with implementation of clinical pathways and standard operation procedures. Read More

View Article
December 2018

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death.

Front Immunol 2018 14;9:2647. Epub 2018 Nov 14.

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai, China.

Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles. The etiologies vary among different subtypes of ALS, and no effective management or medication could be provided to the patients, with the underlying mechanisms incompletely understood yet. Mutations in human (Optineurin), particularly E478G, have been found in many ALS patients. Read More

View Article
November 2018

Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment.

Front Aging Neurosci 2018 21;10:384. Epub 2018 Nov 21.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

In this cross-sectional study, we sought to describe cognitive and neuroimaging profiles of Memory clinic patients with Mild Cognitive Impairment (MCI). 51 MCI patients and 51 controls, matched on age, sex, and socio-economic status (SES), were assessed with an extensive neuropsychological test battery that included a measure of intelligence (General Ability Index, "GAI," from WAIS-IV), and structural magnetic resonance imaging (MRI). MCI subtypes were determined after inclusion, and z-scores normalized to our control group were generated for each cognitive domain in each MCI participant. Read More

View Article
November 2018
1 Read

High expression of TFEB is associated with aggressive clinical features in colorectal cancer.

Onco Targets Ther 2018 13;11:8089-8098. Epub 2018 Nov 13.

Department of Internal Medicine, Tianjin Binhai New Area Dagang Hospital, Tianjin 300270, China.

Objectives: The transcription factor EB (TFEB), a member of the micropthalmia family, has been found to be associated with autophagy and upregulated in some kinds of tumors. However, very few studies focused on TFEB in colorectal cancer (CRC). TFEB expression status and its relevance to clinical features in CRC would be analyzed in this study. Read More

View Article
November 2018

Structured interdisciplinary bedside rounds, in-hospital deaths, and new nursing home placements among older inpatients.

Clin Interv Aging 2018 8;13:2289-2294. Epub 2018 Nov 8.

Department of Geriatric Medicine, Centre for Applied Nursing Research, Western Sydney University and Ingham Institute of Applied Medical Research, Aged Care Research Unit, Liverpool Hospital, Liverpool BC, NSW 1871, Australia.

Purpose: Ineffective interdisciplinary communication is linked to many adverse consequences of hospitalization. This study evaluated the effect of SIBR, a model of care that encourages interdisciplinary communication and patient and family participations, on in-hospital deaths and new nursing home (NH) placements.

Materials And Methods: This before-after study included 3,673 consecutive inpatients of mean age 83. Read More

View Article
November 2018

Concurrent chemoradiation therapy tailored to the older adults with esophageal cancer: state of the art and the future.

Clin Interv Aging 2018 8;13:2275-2287. Epub 2018 Nov 8.

Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, Zhejiang, People's Republic of China,

Purpose: The aim of this study was to review the published literature addressing the question of whether geriatric assessment (GA) should be routinely applied in the treatment of older adults with esophageal cancer (EC) who have received definitive concurrent chemoradiotherapy (dCRT).

Materials And Methods: A literature search of PubMed, Embase, and Cochrane Library was performed. Studies that contained original data outlining the inclusion and exclusion criteria, treatment compliance rate, and severe toxicity reports were reviewed. Read More

View Article
November 2018

Postoperative cognitive dysfunction - current preventive strategies.

Clin Interv Aging 2018 8;13:2267-2273. Epub 2018 Nov 8.

Department of Surgery, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Improving trends in global health care have resulted in a steady increase in the geriatric population. However, as the population ages, surgery is being performed more frequently in progressively older patients and those with higher prevalence of comorbidities. A significant percentage of elderly patients experience transient postoperative delirium following surgery or long-term postoperative cognitive dysfunction (POCD). Read More

View Article
November 2018

Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Molecular Innovation in Lipidology, National Cerebral & Cardiovascular Center Research Institute.

Aims: The EXPLORE-J study aimed to assess lipid management in patients hospitalized for acute coronary syndrome (ACS) and their cardiovascular risk despite undergoing standard therapy. Here, we focused on background characteristics of patients in the EXPLORE-J study to elucidate the current lipid-lowering therapy and its issues in Japan.

Methods: In this multicenter, prospective, observational study (UMIN000018946), consecutive Japanese ACS patients who required hospitalization were registered between April 2015 and August 2016. Read More

View Article
December 2018
1 Read

Diagnostic accuracy of the Geriatric Depression Scale-30, Geriatric Depression Scale-15, Geriatric Depression Scale-5 and Geriatric Depression Scale-4 for detecting major depression: protocol for a systematic review and individual participant data meta-analysis.

BMJ Open 2018 Dec 4;8(12):e026598. Epub 2018 Dec 4.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Introduction: The 30-item Geriatric Depression Scale (GDS-30) and the shorter GDS-15, GDS-5 and GDS-4 are recommended as depression screening tools for elderly individuals. Existing meta-analyses on the diagnostic accuracy of the GDS have not been able to conduct subgroup analyses, have included patients already identified as depressed who would not be screened in practice and have not accounted for possible bias due to selective reporting of results from only better-performing cut-offs in primary studies. Individual participant data meta-analysis (IPDMA), which involves a standard systematic review, then a synthesis of individual participant data, rather than summary results, could address these limitations. Read More

View Article
December 2018
2 Reads

Role of perceived stress in postoperative delirium: an investigation among elderly patients.

Aging Ment Health 2018 Dec 6:1-7. Epub 2018 Dec 6.

c Division of Surgical Critical Care and Trauma, Department of Surgery, Maharaj Nakorn Chiang Mai Hospital , Chiang Mai , Thailand.

Objectives: This study examined levels of perceived stress (PS), postoperative delirium (POD) and associated factors among Thai elderly patients undergoing elective noncardiac surgery.

Background And Aims: Preoperative PS and change after operation have not been widely studied. Moreover, psychological factors associated with PS and POD has been poorly investigated. Read More

View Article
December 2018

Combining Actigraph Link and PetPace Collar Data to Measure Activity, Proximity, and Physiological Responses in Freely Moving Dogs in a Natural Environment.

Animals (Basel) 2018 Dec 4;8(12). Epub 2018 Dec 4.

Geriatric Research Education Clinical Center, VA Maryland Health Care System, Baltimore, MD 21201, USA.

Although several studies have examined the effects of an owner's absence and presence on a dog's physiological responses under experimental conditions over short periods of time (minutes), little is known about the effects of proximity between humans and freely moving dogs under natural conditions over longer periods of time (days). The first aim of our study was to determine whether the combined data generated from the PetPace Collar and Actigraph Link accelerometer provide reliable pulse, respiration, and heart rate variability results during sedentary, light-moderate, and vigorous bouts in 11 freely moving dogs in a foster caretaker environment over 10⁻15 days. The second aim was to determine the effects of proximity (absence and presence of caretaker) and distance (caretaker and dog within 0⁻2 m) on the dogs' physiological responses. Read More

View Article
December 2018

Ethnic Differences in Magnesium Intake in U.S. Older Adults: Findings from NHANES 2005⁻2016.

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Epidemiology, Centre for Public Health, Medical University of Vienna, 1090 Vienna, Austria.

Magnesium plays a crucial role in hundreds of bodily processes relevant to aging, but consumption of dietary magnesium intake has been shown to be inadequate in a large proportion of older adults. Identifying groups at risk of low magnesium intake is important for informing targeted advice. Using data from the National Health and Nutrition Examination Survey (NHANES) 2005⁻2016, we examined the association between ethnicity (Caucasian/African American/Hispanic/other) and magnesium intake in a large representative sample of U. Read More

View Article
December 2018

Mitochondrial DNA variants and pulmonary function in older persons.

Exp Gerontol 2018 Nov 30. Epub 2018 Nov 30.

California Pacific Medical Center Research Institute, San Francisco, CA, United States of America.

Background: We provide the first examination of mitochondrial DNA (mtDNA) variants and pulmonary function in older persons.

Methods: Cross-sectional associations between mtDNA variants and pulmonary function were evaluated as a combined p-values meta-analysis, using data from two independent cohorts of older persons. The latter included white and black participants, aged ≥70 years, from the Lifestyle Interventions and Independence for Elders study (LIFE) (N = 1247) and the Health, Aging and Body Composition study (Health ABC) (N = 731), respectively. Read More

View Article
November 2018

Fall Prevention in Community-Dwelling Older Adults.

Ann Intern Med 2018 Dec;169(11):ITC81-ITC96

From the Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, Washington. (E.A.P., K.R.).

Falls are common among older adults. One in 3 adults aged 65 years or older and 1 in 2 adults aged 80 years or older fall each year. Interventions for prevention have been identified; however, they are often not addressed in primary care practice. Read More

View Article
December 2018

Unmet social support needs among older adults with cancer.

Cancer 2018 Dec 3. Epub 2018 Dec 3.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Adequate social support for older adults is necessary to maintain quality of life and reduce mortality and morbidity. However, little is known regarding the social support needs of older adults with cancer. The objective of the current study was to examine social support needs, specifically the unmet needs, among older adults with cancer. Read More

View Article
December 2018

Cognitive changes in older women after urogynaecological surgery.

Ginekol Pol 2018 ;89(11):587-592

Frauenzimmer Bern AG, Bern, Switzerland.

Objectives: The need for pelvic floor surgery will increase with an aging population in the future. Aim of this prospective study was to evaluate the evolution of cognitive function in elderly women after urogynaecological surgery.

Material And Methods: Between 2010 and 2014, 51 female patients 70 years and older who underwent urogynaecological surgery participated in this study. Read More

View Article
January 2018

A Focus on Patient-Centered Care Required to Address the Trauma of Hospitalization.

Authors:
Cynthia J Brown

JAMA Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Comprehensive Center for Healthy Aging, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham.

View Article
December 2018

Distance Versus On-Site Educational Strategies for Competency-Based Screening, Brief Intervention, and Referral to Treatment Education.

J Addict Nurs 2018 Oct/Dec;29(4):E1-E8

Patricia Kelly, PhD, MPH, RN, FNP, Heather J. Gotham, PhD, Sarah Knopf-Amelung, MA-R, Kendall Kohnle, MA, and Araba Kuofie, BA, School of Nursing and Health Studies, University of Missouri-Kansas City.

Background: Although the individual and public health consequences of alcohol and drug use are substantial, nursing education programs generally lack content on addiction. The goal of this evaluation was to compare the initial outcomes of on-site versus distance methods for training graduate nurse practitioner students in Screening, Brief Intervention, and Referral to Treatment (SBIRT) for substance use.

Method: A nonrandomized two-group pretest-posttest design was used to compare knowledge, attitudes, and skills learning outcomes between on-site (n = 45) and distance (n = 18) family or adult/geriatric Master of Science in Nursing nurse practitioner students receiving SBIRT training. Read More

View Article
December 2018

Biomarkers and postoperative cognitive function: could it be that easy?

Curr Opin Anaesthesiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Anaesthesiology, University Hospital, LMU Munich, Munich.

Purpose Of Review: Neurocognitive dysfunction after surgery is highly relevant in the elderly. The multifactorial manner of this syndrome has made it hard to define an ideal biomarker to predict individual risk and assess diagnosis and severity of delirium [postoperative delirium (POD)] and subsequent postoperative cognitive decline (POCD). This review summarizes recent literature on blood biomarkers for POD/POCD. Read More

View Article
November 2018

Spatial Navigation in the Elderly with Alzheimer's Disease: A Cross-Sectional Study.

J Alzheimers Dis 2018 Nov 26. Epub 2018 Nov 26.

Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Spatial navigation is a fundamental cognitive ability that allows an individual to maintain independence by facilitating the safe movement from one place to another. It emerges as one of the first deficits in patients with Alzheimer's disease (AD).

Objective: To compare spatial navigation performance in the healthy elderly and AD patients through use of the Floor Maze Test (FMT)- an easy-to-apply two-dimensional (2D) maze- and determine which cognitive and functional capacities were associated with performance in this task. Read More

View Article
November 2018

Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.

J Alzheimers Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA.

Little is known about the extracellular matrix (ECM) during progression of AD pathology. Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. We hypothesized that pathologic severity of AD is associated with increases in HA and HA-associated ECM molecules. Read More

View Article
November 2018

Making Function Part of the Conversation: Clinician Perspectives on Measuring Functional Status in Primary Care.

J Am Geriatr Soc 2018 Dec 2. Epub 2018 Dec 2.

San Francisco Veterans Affairs (VA) Medical Center, San Francisco, California.

Objectives: Although there is increasing interest in using functional status to guide clinical decision making, function is seldom routinely assessed in primary care. We explored clinician perspectives on barriers and facilitators to routine measurement of older adults' functional status in primary care settings.

Design: Qualitative study using semistructured interviews. Read More

View Article
December 2018

Anal fistula plug versus rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: a system review and meta-analysis of studies with long term follow-up.

Colorectal Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Intensive Care Unit, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Aim: To compare the effectiveness of the anal fistula plug (AFP) with the rectal advancement flap (RAF) for complex cryptoglandular anal fistulas.

Methods: We conducted a literature search to identify relevant available articles published without language restriction from EMBASE and PubMed databases and the Cochrane Library. Studies comparing outcomes with the AFP versus RAF for complex cryptoglandular anal fistulas were eligible for inclusion. Read More

View Article
November 2018

Football Compared with Usual Care in Men with Prostate Cancer (FC Prostate Community Trial): A Pragmatic Multicentre Randomized Controlled Trial.

Sports Med 2018 Dec 1. Epub 2018 Dec 1.

The University Hospitals' Centre for Health Research, Rigshospitalet, 2100, Copenhagen Ø, Denmark.

Background: Physical activity has been shown to mitigate the unwanted psychological and physiological side effects of prostate cancer treatments, but sustainable exercise possibilities are limited.

Objective: Our objective was to examine whether football in a real-world setting (i.e. Read More

View Article
December 2018

The applause sign in frontotemporal lobar degeneration and related conditions.

J Neurol 2018 Dec 1. Epub 2018 Dec 1.

Neurologische Klinik und Poliklinik, Ludwig Maximilians Universität München, Munich, Germany.

The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP). Read More

View Article
December 2018

Development of a Population Pharmacokinetic Model of Vancomycin and its Application in Chinese Geriatric Patients with Pulmonary Infections.

Eur J Drug Metab Pharmacokinet 2018 Nov 30. Epub 2018 Nov 30.

Department of Nephrology, Peking University First Hospital, No.1 Dahongluochang Street, Xicheng District, Beijing, China.

Background: The optimal use of vancomycin in the elderly requires information about the drug's pharmacokinetics and the influence of various factors on the drug's disposition. However, because of sampling restrictions, it is often difficult to perform traditional pharmacokinetic studies in elderly patients.

Objective: This study was conducted to estimate the population pharmacokinetics of vancomycin in Chinese geriatric patients (age ≥ 65 years) with pulmonary infections and to explore the clinical application of this information for vancomycin dose individualization. Read More

View Article
November 2018

L-type calcium channel blockers and a symptom complex mimicking de Melo-Souza's syndrome.

Neurol Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.

View Article
December 2018

OASIS: The Obesity Awareness and Insight Scale.

Obes Med 2018 Mar 12;9:38-44. Epub 2018 Feb 12.

Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

Aims: Impaired illness awareness or not accepting that one has obesity is an understudied phenomenon that may negatively influence treatment adherence and clinical outcomes. The purpose of this study was to perform a systematic review of available measures of obesity awareness, and subsequently develop and validate a novel scale that measures the core domains of obesity awareness.

Methods: A systematic review of the literature revealed no illness specific measure of subjective obesity awareness. Read More

View Article

Recent advances in non-surgical management of cancer in the elderly.

F1000Res 2018 15;7. Epub 2018 Nov 15.

Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA.

This article summarizes the seminal publications from mid-2016 through 2017 in the area of medical care for older adults with cancer. Areas addressed include chemotherapy tolerance and efficacy in the aged, geriatric fitness assessments, and advancements in palliative and supportive care. The practice-changing finding from this past year's publications is that antipsychotics should not be used in the management of terminal delirium in older adults receiving palliative care. Read More

View Article
November 2018

Antimalarials - are they effective and safe in rheumatic disease? Focus on the neuropsychiatric side effects.

Authors:
Cirro Manzo

Reumatologia 2018 31;56(5):333-334. Epub 2018 Oct 31.

Internal and Geriatric Department, Rheumatologic Outpatient Clinic Hospital "Mariano Lauro", Sant'Agnello, Italy.

View Article
October 2018

Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):88-96

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. Read More

View Article
November 2018

Cytotoxic therapy in acute myeloid leukemia: not quite dead yet.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):51-62

Department of Medicine, Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI.

Given the recent approvals of new agents for acute myeloid leukemia (AML), a clinical trial pipeline stocked with novel therapies, and the rapid integration of imaginative approaches in diseases like acute lymphocytic leukemia and chronic lymphocytic leukemia, it is reasonable to ask whether treatment of AML might finally depart from the classical cytotoxic induction therapy that has been employed since the 1970s. However, for better or worse, in 2018, cytotoxic induction regimens remain the standard of care for most patients. Indeed, the future likely lies in combinations of therapies that act with a spectrum of mechanisms. Read More

View Article
November 2018
2 Reads

Associated Injuries Are Frequent and Severe Among Geriatric Patients With Zygomatico-Orbital Fractures.

J Oral Maxillofac Surg 2018 Nov 5. Epub 2018 Nov 5.

Professor, Department of Oral and Maxillofacial Diseases, Institute of Dentistry, University of Turku and Turku University Hospital, Turku, Finland.

Purpose: Associated injuries (AIs) are hypothesized to be frequent in geriatric zygomatico-orbital (ZMO) fractures. The study aim was to determine the relation between ZMO fractures and AIs in geriatric patients compared with younger adult patients.

Patients And Methods: A retrospective case-and-control study was carried out on geriatric patients at least 65 years of age (n = 93) and younger adult patients 20 to 30 years of age (n = 68) diagnosed with pure unilateral ZMO fractures. Read More

View Article
November 2018

Impairments in Individual Autonomous Living Tasks and Time to Self-Care Disability in Middle-Aged and Older Adults.

J Am Med Dir Assoc 2018 Nov 28. Epub 2018 Nov 28.

Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND.

Objectives: Impairments in specific tasks that are necessary for independent living may identify future self-care limitations, and the use of time-varying covariates can better capture the fluidity in functional capacity trajectories over time. The purpose of this study was to determine the associations between individual instrumental activities of daily living (IADL) impairments and time to activities of daily living (ADL) disability for middle-aged and older adults in the United States.

Design: Longitudinal panel. Read More

View Article
November 2018

The Effects of Exercise on Falls in Older People With Dementia Living in Nursing Homes: A Randomized Controlled Trial.

J Am Med Dir Assoc 2018 Nov 28. Epub 2018 Nov 28.

Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden; Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.

Objectives: To investigate exercise effects on falls in people with dementia living in nursing homes, and whether effects were dependent on sex, dementia type, or improvement in balance. A further aim was to describe the occurrence of fall-related injuries.

Design: A cluster-randomized controlled trial. Read More

View Article
November 2018

Threshold for a Reduction in Anticholinergic Burden to Decrease Behavioral and Psychological Symptoms of Dementia.

J Am Med Dir Assoc 2018 Nov 28. Epub 2018 Nov 28.

Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, France; Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, France. Electronic address:

Background: A high anticholinergic burden (AB) is associated with the occurrence of behavioral and psychological symptoms (BPSDs), which are frequent in dementia.

Objectives: Our aim was to determine the threshold for a reduction in AB that would lead to a clinically significant improvement in BPSDs (in terms of frequency, severity, and disruptiveness).

Design: A single-center prospective study. Read More

View Article
November 2018
1 Read

Age stratified analysis of pre-operative factors impacting unplanned thirty day readmission in geriatric general surgery.

Am J Surg 2018 Nov 14. Epub 2018 Nov 14.

Division of General Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Background: The geriatrics population can no longer be considered as one homogenous group when it comes to patient-centric and value-based care. We aim to determine if there are pre-operative factors which differ between geriatric age strata (65-74, 75-84, 85 + years) that impact unplanned thirty-day readmission.

Methods: 2015 NSQIP general surgery procedure data was utilized. Read More

View Article
November 2018

Determining the impact of culture on venous thromboembolism prevention in trauma patients: A Southwestern Surgical Congress Multicenter trial.

Am J Surg 2018 Nov 20. Epub 2018 Nov 20.

Scott & White Medical Center - Temple, TX, USA.

Introduction: Venous thromboembolism (VTE) remains one of the principal causes of morbidity and death in trauma patients that survive the first 24 h. Recent literature on VTE prevention focuses on choice of chemoprophylaxis, specifically unfractionated heparin (UFH) versus low molecular weight heparin (LMWH). This singular focus on a multifactorial process may be inadequate to fully understand the optimal approach to VTE prevention. Read More

View Article
November 2018
1 Read