83,697 results match your criteria Geographic Tongue


Beyond reasonable drought: hotspots reveal a link between the 'Big Dry' and cryptosporidiosis in Australia's Murray Darling Basin.

J Water Health 2018 Dec;16(6):1033-1037

National Centre for Geographic and Resource Analysis in Primary Health Care, Australian National University, Canberra, 2600, Australia.

There is little evidence on how the health impacts of drought vary spatially and temporally. With a focus on waterborne cryptosporidiosis, we identify spatio-temporal hotspots and by using interrupted time series analysis, examine the impact of Australia's Big Dry (2001-2009) in these disease clusters in the Murray Darling Drainage Basin. Analyses revealed a statistically significant hotspot in the north of the Australian Capital Territory (ACT) and a hotspot in the north-eastern end of the basin in Queensland. Read More

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December 2018

PANCREATIC CANCER IN BRAZIL: MORTALITY TRENDS AND PROJECTIONS UNTIL 2029.

Arq Gastroenterol 2018 Jul-Sep;55(3):230-236

Universidade Federal do Rio Grande do Norte, Departamento de Saúde Coletiva, Programa de Pós-Graduação em Saúde Coletiva, Natal, RN, Brasil.

Background: Pancreatic cancer is one of the main cancer-related causes of death in developed countries, and one of the most lethal malignant neoplasms. This type of cancer is classified as the ninth most frequent in the world.

Objective: Analyze temporal trends for pancreatic cancer in Brazil in the period 2000-2014 and calculate mortality projections for the period 2015-2029. Read More

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February 2018
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Meta-analysis on the association between xeroderma pigmentosum Group A A23G polymorphism and esophageal cancer in a Chinese population.

J Cancer Res Ther 2018 Dec;14(Supplement):S1173-S1177

Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China.

Aim Of The Study: Several studies have evaluated the correlation between xeroderma pigmentosum Group A (XPA) A23G polymorphism (rs 1800975) and esophageal cancer in Chinese people. However, the results are inconsistent. To assess the effects of XPA A23G variants on the risk for development of esophageal cancer in the Chinese population, a meta-analysis was performed. Read More

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December 2018
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Glutathione S-transferase mu-1, glutathione S-transferase theta-1 null genotypes, and oral cancer risk: A meta-analysis in the Chinese population.

J Cancer Res Ther 2018 Dec;14(Supplement):S1052-S1056

Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401331, China.

Aim Of Study: Several studies have evaluated the correlation between glutathione S-transferase mu-1 (GSTM1), GST theta-1 (GSTT1) polymorphisms and oral cancer in Chinese people. However, the results are inconsistent. To assess the effects of GSTM1, GSTT1 null genotypes on the risk for development of oral cancer in the Chinese population, a meta-analysis was performed. Read More

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December 2018

Sediment pollution in an urban water supply lake in southern Brazil.

Environ Monit Assess 2018 Dec 11;191(1):12. Epub 2018 Dec 11.

Soil Department, UFRGS, Porto Alegre, Brazil.

Urbanization and anthropogenic activities create many environmental issues in urban water supply reservoirs, especially in metropolitan regions. Thus, this study was carried out aiming to evaluate the variance in the physical-chemical characteristics of bottom sediment along the Lake Guaíba, Brazil. Lake Guaíba is a freshwater lake situated in a metropolitan region in southern Brazil, being the main water supply to the region. Read More

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December 2018

Microbial Identification Using DNA Target Amplification and Sequencing: Clinical Utility and Impact on Patient Management.

Open Forum Infect Dis 2018 Nov 10;5(11):ofy257. Epub 2018 Oct 10.

Division of Geographic Medicine and Infectious Diseases.

Broad-range polymerase chain reaction (PCR) is increasingly used in patients with culture-negative infections; however, few studies have assessed the diagnostic utility of this test in this context. We performed a retrospective cohort study of patients who had clinical specimens sent for broad-range PCR, aiming to evaluate performance and determine impact on patient management. Organisms were identified in 21/71 samples. Read More

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November 2018

subsp. , the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups.

Open Vet J 2018 26;8(4):393-400. Epub 2018 Oct 26.

Consultant, The Oaks, Nutshell Lane, Upper Hale, Farnham, Surrey GU9 0HG, UK.

subsp. , the cause of the World Organisation of Animal Health- listed contagious caprine pleuropneumonia, is a member of the cluster which comprises five pathogenic mycoplasmas of ruminants. These mycoplasmas are closely related immunologically and genetically which can lead to difficulties for differential diagnosis. Read More

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October 2018

Migration phenology determines niche use of East Asian buntings (Emberizidae) during stopover.

Curr Zool 2018 Dec 6;64(6):681-692. Epub 2018 Feb 6.

Institute of Avian Research "Vogelwarte Helgoland", An der Vogelwarte 21, Wilhelmshaven, Germany.

Stopover niche utilization of birds during migration has not gained much attention so far, since the majority of the studies focuses on breeding or wintering areas. However, stopover sites are crucial for migratory birds. They are often used by a multitude of species, which could lead to increased competition. Read More

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December 2018

Alcoholic liver disease and risk of cholangiocarcinoma: a systematic review and meta-analysis.

Onco Targets Ther 2018 20;11:8211-8219. Epub 2018 Nov 20.

Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China,

Background: With the purpose of elevating the risk of cholangiocarcinoma (CCA), alcoholic liver disease (ALD) was shown. Nonetheless, the findings were controversial. Herein, a meta-analysis and a systematic review were conducted to study the relation as mentioned above. Read More

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November 2018

Spatio-temporal distribution analysis of zoonotic cutaneous leishmaniasis in Qom Province, Iran.

J Parasit Dis 2018 Dec 13;42(4):570-576. Epub 2018 Oct 13.

6Department of Public Health, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.

Geographic information system (GIS) nowadays is one of the most helpful epidemiological tools for identifying the high risk areas of cutaneous leishmaniasis (CL). This study was conducted to determine the spatio-temporal distribution of CL in Qom province during 2009-2017. In a cross-sectional study, for the survey of spatial dispersion of CL in the study region, the incidence rate of disease was calculated in all of 23 villages during 2009-2017. Read More

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December 2018

Mammal collections of the Western Hemisphere: a survey and directory of collections.

J Mammal 2018 Dec;99(6):1307-1322

Department of Biology, Angelo State University, San Angelo, TX, USA.

As a periodic assessment of the mammal collection resource, the Systematic Collections Committee (SCC) of the American Society of Mammalogists undertakes decadal surveys of the collections held in the Western Hemisphere. The SCC surveyed 429 collections and compiled a directory of 395 active collections containing 5,275,155 catalogued specimens. Over the past decade, 43 collections have been lost or transferred and 38 new or unsurveyed collections were added. Read More

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December 2018

A comparison of satellite-based indices for hazard assessment of MSW open dumps using spatial analysis.

Waste Manag Res 2018 Dec 11:734242X18815963. Epub 2018 Dec 11.

1 Remote Sensing and GIS Group, Department of Space Science, University of the Punjab, Lahore, Pakistan.

This study compares the suitability of different satellite-based vegetation indices (VIs) for environmental hazard assessment of municipal solid waste (MSW) open dumps. The compared VIs, as bio-indicators of vegetation health, are normalized difference vegetation index (NDVI), soil adjusted vegetation index (SAVI), and modified soil adjusted vegetation index (MSAVI) that have been subject to spatio-temporal analysis. The comparison has been made based on three criteria: one is the exponential moving average (EMA) bias, second is the ease in visually finding the distance of VI curve flattening, and third is the radius of biohazardous zone in relation to the waste heap dumped at them. Read More

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December 2018

High risk Epstein-Barr virus variants characterized by distinct polymorphisms in the EBER locus are strongly associated with nasopharyngeal carcinoma.

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.

Whether certain variants of Epstein-Barr virus (EBV) are linked to the pathogenesis of nasopharyngeal carcinoma (NPC), which shows a marked geographic restriction, remains an unresolved issue. We performed a case-control study comparing genomic sequences of EBV isolated from saliva samples of 142 population carriers with those from primary tumour biopsies derived from 62 patients with NPC of Hong Kong. Cluster analysis discovered five EBV subgroups 1A-C and 2A-B amongst the population carriers in contrast to the predominance of 1A and -B in the majority of NPC. Read More

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December 2018

The diversity of population responses to environmental change.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France.

The current extinction and climate change crises pressure us to predict population dynamics with ever-greater accuracy. Although predictions rest on the well-advanced theory of age-structured populations, two key issues remain poorly explored. Specifically, how the age-dependency in demographic rates and the year-to-year interactions between survival and fecundity affect stochastic population growth rates. Read More

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December 2018

Geographic variations in racial disparities in postmastectomy breast reconstruction: A SEER database analysis.

Breast J 2018 Dec 9. Epub 2018 Dec 9.

Department of Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri.

The purpose of this study was to determine whether racial disparities in reconstruction in the United States vary by geographic region. The SEER database years 2000-2013 was queried for all mastectomies in women ages 20-85+. Logistic regression was used to examine the main effects and interaction of race and geographic region on reconstruction. Read More

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December 2018
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Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease.

J Mol Med (Berl) 2018 Dec 8. Epub 2018 Dec 8.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More

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December 2018

Comprehensive cancer control planning in the Pacific: the Cancer Council of the Pacific Islands a multi-national regional coalition.

Cancer Causes Control 2018 Dec 10. Epub 2018 Dec 10.

Cancer Council of the Pacific Islands, Yap State Department of Health Services, Yap State, Federated States of Micronesia, c/o Department of Family Medicine and Community Health, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo Street, MEB 224, Honolulu, HI, 96813, USA.

Introduction: In the early 1990s, a comprehensive cancer control (CCC) approach was developed in the United States (US). In 2003, the US-Affiliated Pacific Islands (USAPI) adopted the CCC approach through a regional coalition, the Cancer Council of the Pacific Islands (CCPI). Using the CCC approach, the CCPI developed jurisdiction-specific cancer coalitions and initiated their respective cancer plans. Read More

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December 2018

Atovaquone-proguanil chemoprophylaxis in the era of Tafenoquine.

J Travel Med 2018 Dec 11. Epub 2018 Dec 11.

From the Center for Geographic Medicine and Department of Medicine C at the Sheba medical center, Tel Hashomer.

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December 2018

Sex and Race Differences in the Association of Incident Ischemic Stroke With Risk Factors.

JAMA Neurol 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, Larner College of Medicine, Colchester, Vermont.

Importance: Race-specific and sex-specific stroke risk varies across the lifespan, yet few reports describe sex differences in stroke risk separately in black individuals and white individuals.

Objective: To examine incidence and risk factors for ischemic stroke by sex for black and white individuals.

Design, Setting, And Participants: This prospective cohort study included participants 45 years and older who were stroke-free from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, enrolled from the continental United States 2003 through 2007 with follow-up through October 2016. Read More

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December 2018

Problems and solutions in IGRT for cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):517-527. Epub 2018 May 26.

Centro Medico Imbanaco, Radiation Therapy Unit, Colombia.

The contribution of Image-guided Radiotherapy (IGRT) to modern radiotherapy is undeniable, being the way to bring into daily practice the dosimetric benefits of Intensity-Modulated Radiotherapy (IMRT). Organ and target motion is constant and unpredictable at the pelvis, thus posing a challenge to the safe execution of IMRT. There are potential benefits of IMRT in the radical treatment of cervical cancer patients, both in terms of dose escalation and decrease of toxicity. Read More

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Draft Genome Sequences of the Escherichia coli Reference (ECOR) Collection.

Microbiol Resour Announc 2018 Oct 11;7(14). Epub 2018 Oct 11.

Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland, USA.

Here, we report the genomes of all 72 isolates belonging to the Escherichia coli reference (ECOR) collection. Strains in this collection were isolated from diverse hosts and geographic locations and have been used for more than 30 years to represent the phylogenetic diversity of E. coli. Read More

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October 2018

Complete Genome Sequence of Houston Virus, a Newly Discovered Mosquito-Specific Virus Isolated from Culex quinquefasciatus in Mexico.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.

We fully sequenced the genome of Houston virus, a recently discovered mosquito-associated virus belonging to the newly established family Mesoniviridae. The isolate was recovered from Culex quinquefasciatus in southern Mexico, which shows that the geographic range of Houston virus is not restricted to the United States in North America. Read More

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September 2018

Mesquite bugs, other insects, and a bat in the diet of pallid bats in southeastern Arizona.

PeerJ 2018 4;6:e6065. Epub 2018 Dec 4.

Sonoran Science Solutions, Tucson, AZ, United States of America.

The pallid bat () is a species of western North America, inhabiting ecoregions ranging from desert to oak and pine forest. They are primarily insectivorous predators on large arthropods that occasionally take small vertebrate prey, and are at least seasonally omnivorous in certain parts of their geographic range where they take nectar from cactus flowers and eat cactus fruit pulp and seeds. Until recently, mesquite bugs were primarily tropical-subtropical inhabitants of Mexico and Central America but have since occupied the southwestern United States where mesquite trees occur. Read More

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December 2018

Reducing protected lands in a hotspot of bee biodiversity: bees of Grand Staircase-Escalante National Monument.

PeerJ 2018 4;6:e6057. Epub 2018 Dec 4.

Santa Fe, NM, USA.

Grand Staircase-Escalante National Monument is a federally protected area found in central southern Utah. Designated in 1996 by President William J. Clinton, it was recently reduced in size by President Donald J. Read More

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December 2018

Epidemiological profile of dengue in Zhejiang Province, southeast China.

PLoS One 2018 11;13(12):e0208810. Epub 2018 Dec 11.

Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, China.

Background: Dengue is one of the most important vector-bore infectious diseases in China because of its drastic increase in incidence, geographic extension and profound influence on China's economy. This study aims to retrospectively uncover the epidemiological profile of dengue in Zhejiang, one of the most developed provinces in China, and to find the problem existing in dengue control and prevention.

Methodology: Descriptive analyses on the dengue incidence and associated factors were performed. Read More

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December 2018

Evaluating Barriers and Opportunities in Delivering High-Quality Oncology Care in a Resource-Limited Setting Using a Comprehensive Needs Assessment Tool.

J Glob Oncol 2018 Dec(4):1-9

Chika R. Nwachukwu, Lynn Million, Shruti Sheth, Hope Qamoos, and Ami S. Bhatt, Stanford University School of Medicine; Michele Barry, Center for Innovation in Global Health, Stanford University, Stanford; Omobola Mudasiru, University of California Berkley, Berkeley, CA; Joseph O. Onah, Anita Okemini, and Mojisola Rhodes, Clinton Health Access Initiative, Nigeria Country Office; Adekunbiola A. Banjo and Muhameed Habeebu, Lagos University Teaching Hospital, Lagos; Anita Okemini, ONE Campaign, Nigeria Country Office, Abuja; and Tajudeen A. Olasinde, Amadu Bello University Teaching Hospital, Zaira, Nigeria.

Purpose: Despite recognition of both the growing cancer burden in low- and middle-income countries and the disproportionately high mortality rates in these settings, delivery of high-quality cancer care remains a challenge. The disparities in cancer care outcomes for many geographic regions result from barriers that are likely complex and understudied. This study describes the development and use of a streamlined needs assessment questionnaire (NAQ) to understand the barriers to providing quality cancer care, identifies areas for improvement, and formulates recommendations for implementation. Read More

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December 2018

The natural history of (Reeve, 1859) from Southern Chile (Gastropoda, Calyptraeidae).

Zookeys 2018 21(798):1-22. Epub 2018 Nov 21.

Instituto de Ciencias Marinas y Limnológicas, Universidad Austral de Chile, Casilla 567, Valdivia, Chile.

Hard bottom communities of the Reloncaví Estuary and adjacent areas, Region de los Lagos, Chile (42°S), were studied between 2008 and 2011. All hard substrates between the lower intertidal and 25 m depth were dominated by the calyptraeid gastropods, and . Epibenthic coverage of the hard bottoms markedly decreased further down with the exception of vertical cliffs. Read More

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November 2018

Projecting social contact matrices to different demographic structures.

PLoS Comput Biol 2018 Dec 7;14(12):e1006638. Epub 2018 Dec 7.

Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zargoza, Zargoza, Spain.

The modeling of large-scale communicable epidemics has greatly benefited in the last years from the increasing availability of highly detailed data. Particullarly, in order to achieve quantitative descriptions of the evolution of epidemics, contact networks and mixing patterns are key. These heterogeneous patterns depend on several factors such as location, socioeconomic conditions, time, and age. Read More

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December 2018

Draft Opioid-Prescribing Guidelines for Uncomplicated Normal Spontaneous Vaginal Birth.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

University of Illinois at Chicago, Chicago, Illinois; Novartis Oncology, East Hanover, New Jersey; U.S. Department of Health and Human Services, Washington, DC; and Premier, Inc, Charlotte, North Carolina.

Women who experience an uncomplicated vaginal delivery have acute intrapartum pain and variable pain in the immediate postpartum period. Although the Centers for Disease Control and Prevention (CDC) has urged clinicians to improve opioid-prescribing behavior, there are no published clinical practice guidelines for prescribing opioids during labor and delivery and at discharge for patients with uncomplicated normal spontaneous vaginal delivery. To address the knowledge gap regarding guidelines for pain management in this population, we used the national Premiere Health Care Database for deliveries of uncomplicated vaginal births from January 1, 2014, to December 31, 2016, to determine the prevalence of opioid administration. Read More

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December 2018
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Cohort Analysis of Immigrant Rhetoric on Timely and Regular Access of Prenatal Care.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Obstetrics & Gynecology, Divisions of Maternal-Fetal Medicine, Baylor College of Medicine & Texas Children's Hospital, Houston, Texas; St. Olaf College, Northfield, Minnesota; the University of Texas at Austin, Austin, Texas; and the National School for Tropical Medicine at Baylor College of Medicine, and the Department of Molecular & Human Genetics at Baylor College of Medicine, Houston, Texas.

Objective: To assess whether recent anti-immigration rhetoric is significantly associated with inadequate prenatal care.

Methods: This was a population-based cohort study (2011-2017). In their native language, patients were consented and queried regarding country of origin and time in the United States. Read More

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December 2018

Efficacy of Misoprostol Alone for First-Trimester Medical Abortion: A Systematic Review.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Gynuity Health Projects, New York, New York; the University of Colorado Hospital Anschutz Medical Campus, Aurora, Colorado; and the Department of Mathematics and Statistics, Elon University, Elon, North Carolina.

Objective: To summarize available data on the effectiveness and safety of single-agent misoprostol for medical abortion in the first trimester.

Data Sources: We searched MEDLINE, CABI, Cochrane, EMBASE, LILACS, the Web of Science, and ClinicalTrials.gov for English-language studies that evaluated misoprostol alone for abortion of a viable pregnancy in the first trimester. Read More

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December 2018

A review of racial/ethnic disparities in pediatric trauma care, treatment and outcomes.

J Trauma Acute Care Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Division of Pediatric Surgery, University of Minnesota, Minneapolis, Minnesota.

Health disparities are an increasingly researched topic in the United States. Evidence of disparities found across the spectrum of health care includes pediatric patients. The purpose of this review is to comprehensively summarize disparities among pediatric trauma patients, evaluating both emergency department and hospital treatment and outcomes. Read More

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December 2018

Community-based learning enhances doctor retention.

Educ Health (Abingdon) 2018 May-Aug;31(2):114-118

Office of Collaborative Project to Increase Production of Rural Doctor, Ministry of Public Health, Bangkok, Thailand.

Background: Rural doctor shortage is a problem in many countries. Factors associated with doctor retention were reported such as colleagues, workload, accommodations, transportation, proximity of family and friends, incentives and career path. Rural background recruitment, increasing the quantity of doctor production to supply in rural and remote areas, and regulation are claimed to alleviate doctor scarcity in rural communities. Read More

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December 2018

Improving vaccines against using synthetic glycans.

Proc Natl Acad Sci U S A 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomolecular Systems, Max-Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany;

remains a deadly disease in small children and the elderly even though conjugate and polysaccharide vaccines based on isolated capsular polysaccharides (CPS) are successful. The most common serotypes that cause infection are used in vaccines around the world, but differences in geographic and demographic serotype distribution compromises protection by leading vaccines. The medicinal chemistry approach to glycoconjugate vaccine development has helped to improve the stability and immunogenicity of synthetic vaccine candidates for several serotypes leading to the induction of higher levels of specific protective antibodies. Read More

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December 2018
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Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue.

Proc Natl Acad Sci U S A 2018 Dec 7. Epub 2018 Dec 7.

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305;

Dengue virus (DENV) infection can result in severe complications. However, the understanding of the molecular correlates of severity is limited, partly due to difficulties in defining the peripheral blood mononuclear cells (PBMCs) that contain DENV RNA in vivo. Accordingly, there are currently no biomarkers predictive of progression to severe dengue (SD). Read More

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December 2018

Does money relieve depression? Evidence from social pension expansions in China.

Soc Sci Med 2018 Dec 4;220:411-420. Epub 2018 Dec 4.

Department of Health Policy and Management, Yale School of Public Health, USA; Institution for Social and Policy Studies, Yale University, USA. Electronic address:

We estimate the impact of pension enrollment on mental well-being using China's New Rural Pension Scheme (NRPS), the largest existing pension program in the world. Since its launch in 2009, more than 400 million Chinese have enrolled in the NRPS. We first describe plausible pathways through which pension may affect mental health. Read More

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December 2018

Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study.

Mult Scler Relat Disord 2018 Dec 2;28:17-25. Epub 2018 Dec 2.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. Electronic address:

Background: Current guidelines recommend regular neurological MS care in persons diagnosed with MS, but little is known about implementation of this recommendation or potential access barriers. This study examined disease-specific and sociodemographic differences between MS patients in Neurological Care (NeC), General Practitioner Care (GPC), or no Physician Care (NoPC) to identify group differences and characteristics that may suggest care access barriers.

Methods: Patient-reported data were analyzed from 1038 Swiss Multiple Sclerosis Registry participants by means of multivariable regression to identify systematic differences across the three care groups. Read More

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December 2018
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Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.

Eur J Med Chem 2018 Nov 28;163:256-265. Epub 2018 Nov 28.

Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49, bus 1041, 3000, Leuven, Belgium. Electronic address:

Cyclin G-associated kinase (GAK) is a cellular regulator of the clathrin-associated host adaptor proteins AP-1 and AP-2, which regulates intracellular trafficking of dengue virus during early and late stages of the viral lifecycle. Previously, the discovery of isothiazolo[4,3-b]pyridines as potent and selective GAK inhibitors with promising antiviral activity was reported. In this manuscript, the synthesis of isothiazolo[4,3-b]pyridines with a carbon-linked substituent at position 3 is described by the application of regioselective Suzuki and Sonogashira coupling reactions. Read More

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November 2018

Growth-disrupting Murraya koenigii leaf extracts on Anopheles gambiae larvae and identification of associated candidate bioactive constituents.

Acta Trop 2018 Dec 7. Epub 2018 Dec 7.

Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, PO Box, 230-80108, Kilifi, Kenya; Biotechnology Research Institute - Kenya Agricultural and Livestock Research Organization, PO Box, 362-00902, Kikuyu, Kenya. Electronic address:

Plant-based constituents have been proposed as eco-friendly alternatives to synthetic insecticides for control of mosquito vectors of malaria. In this study, we first screened the effects of methanolic leaf extracts of curry tree (Murraya koenigii) growing in tropical (Mombasa, Malindi) and semi-arid (Kibwezi, and Makindu) ecological zones of Kenya on third instar An. gambiae s. Read More

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December 2018

Geographic distributions, phenotypes, and phylogenetic relationships of Phalloceros (Cyprinodontiformes: Poeciliidae): insights about diversification among sympatric species pools.

Mol Phylogenet Evol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ecology and Evolutionary Biology, University of Michigan, 1105 N. University, 48109, Ann Arbor MI, USA.

With 22 described species, Phalloceros is the most species-rich genus of Poeciliidae in South America. Phalloceros diversity is characterized by high degrees of endemism and sympatry in coastal and inland drainages in southeastern South America. The taxa are also characterized by pronounced differentiation in sexual characters (i. Read More

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December 2018

The development of an index of rural deprivation: A case study of Norfolk, England.

Soc Sci Med 2018 Sep 15. Epub 2018 Sep 15.

Norwich Medical School, University of East Anglia, United Kingdom.

Geographical deprivation indices such as the English Index of Multiple Deprivation (IMD) have been widely used in healthcare research and planning since the mid-1980s. However, such indices normally provide a measure of disadvantage for the whole population and can be inflexible to adaptation for specific geographies or purposes. This can be an issue, as the measurement of deprivation is subjective and situationally relative, and the type of deprivation experienced within rural areas may differ from that experienced by urban residents. Read More

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September 2018

Ecosystem Traits Linking Functional Traits to Macroecology.

Trends Ecol Evol 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

As the range of studies on macroecology and functional traits expands, integration of traits into higher-level approaches offers new opportunities to improve clarification of larger-scale patterns and their mechanisms and predictions using models. Here, we propose a framework for quantifying 'ecosystem traits' and means to address the challenges of broadening the applicability of functional traits to macroecology. Ecosystem traits are traits or quantitative characteristics of organisms (plants, animals, and microbes) at the community level expressed as the intensity (or density) normalized per unit land area. Read More

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December 2018

Update on the epidemiology, risk factors, and disease outcomes of axial spondyloarthritis.

Best Pract Res Clin Rheumatol 2018 04 16;32(2):241-253. Epub 2018 Nov 16.

Rheumatology Department, Cochin Hospital, Paris, France; Inserm (U1153), Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.

Axial spondyloarthritis (axSpA) is the prototype of a class of a rheumatic chronic inflammatory disease named spondyloarthritis (SpA). The prevalence of axSpA ranges between 0.1% and 1. Read More

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Reemergence of West Nile Virus Infections in Southern Greece, 2017.

Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.

Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Greece experienced the largest European West Nile virus (WNV) outbreak in 2010 since the 1996 Romania epidemic. West Nile virus reemerged in southern Greece during 2017, after a 2-year hiatus of recorded human cases, and herein laboratory findings, clinical features, and geographic distribution of WNV cases are presented. Clinical specimens from patients with clinically suspected WNV infection were sent from local hospitals to the Microbiology Department of Medical School, National and Kapodistrian University of Athens, and were tested for the presence of specific anti-WNV antibodies and WNV RNA. Read More

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December 2018

A comparative quantitative study of utilizing artificial intelligence on electronic health records in the USA and China during 2008-2017.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):117. Epub 2018 Dec 7.

School of Information Science and Technology, Guangdong University of Foreign Studies, Guangzhou, China.

Background: The application of artificial intelligence techniques for processing electronic health records data plays increasingly significant role in advancing clinical decision support. This study conducts a quantitative comparison on the research of utilizing artificial intelligence on electronic health records between the USA and China to discovery their research similarities and differences.

Methods: Publications from both Web of Science and PubMed are retrieved to explore the research status and academic performances of the two countries quantitatively. Read More

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December 2018
1.496 Impact Factor

Space-time heterogeneity of hand, foot and mouth disease in children and its potential driving factors in Henan, China.

BMC Infect Dis 2018 Dec 7;18(1):638. Epub 2018 Dec 7.

China National Center for Food Safety Risk Assessment, Beijing, 100022, China.

Background: Hand, foot and mouth disease (HFMD) has become a substantial threat recently. However few studies have quantified spatiotemporal heterogeneity of HFMD and detected spatiotemporal interactive effect of potential driving factors on this disease.

Methods: Using GeoDetector and Bayesian space-time hierarchy model, we characterized the epidemiology of HFMD in Henan, one of the largest population provinces in China, from 2012 to 2013, and quantified the impacts of potential driving factors. Read More

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December 2018
2.613 Impact Factor

Small-area spatial statistical analysis of malaria clusters and hotspots in Cameroon;2000-2015.

BMC Infect Dis 2018 Dec 7;18(1):636. Epub 2018 Dec 7.

Department of Epidemiology and Biostatistics, School of Public Health, Shandong University Cheeloo College of Medicine , Jinan, 250012, People's Republic of China.

Background: Malaria prevalence in Cameroon is a major public health problem both at the regional and urban-rural geographic scale. In 2016, an estimated 1.6 million confirmed cases, and 18,738 cases were reported in health facilities and communities respectively, with about 8000 estimated deaths. Read More

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December 2018

First genome-wide CNV mapping in FELIS CATUS using next generation sequencing data.

BMC Genomics 2018 Dec 10;19(1):895. Epub 2018 Dec 10.

Department of Veterinary Medicine, University of Milan, 20122, Milan, Italy.

Background: Copy Number Variations (CNVs) have becoming very significant variants, representing a major source of genomic variation. CNVs involvement in phenotypic expression and different diseases has been widely demonstrated in humans as well as in many domestic animals. However, genome wide investigation on these structural variations is still missing in Felis catus. Read More

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December 2018

Alignment-free genome comparison enables accurate geographic sourcing of white oak DNA.

BMC Genomics 2018 Dec 10;19(1):896. Epub 2018 Dec 10.

Quantitative and Computational Biology Program, University of Southern California, Los Angeles, CA, 90089, USA.

Background: The application of genomic data and bioinformatics for the identification of restricted or illegally-sourced natural products is urgently needed. The taxonomic identity and geographic provenance of raw and processed materials have implications in sustainable-use commercial practices, and relevance to the enforcement of laws that regulate or restrict illegally harvested materials, such as timber. Improvements in genomics make it possible to capture and sequence partial-to-complete genomes from challenging tissues, such as wood and wood products. Read More

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December 2018

Trends in Geographic Rates of HIV Diagnoses Among Black Females in the United States, 2010-2015.

J Womens Health (Larchmt) 2018 Dec 8. Epub 2018 Dec 8.

1 Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia .

Background: HIV diagnoses among females in the United States declined 22% from 2010 to 2015, including a 27% decline in diagnoses among black females. Despite this progress, disparities persist. Black females accounted for 60% of new HIV diagnoses among females in 2015. Read More

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December 2018