931,654 results match your criteria Genitourinary medicine[Journal]


The therapeutic potential of curcumin: A review of clinical trials.

Eur J Med Chem 2018 Dec 7;163:527-545. Epub 2018 Dec 7.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 11369, Iran; Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, R3B 2G3, Canada. Electronic address:

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Read More

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December 2018
3 Reads

Prepared for the Unexpected: Accessory Ovaries with Abernethy Malformation.

J Minim Invasive Gynecol 2018 Dec 12. Epub 2018 Dec 12.

Oregon Health & Science University, Department of Surgery.

Supernumerary and accessory ovaries are collectively coined ectopic ovaries. These are rarely encountered by the benign gynecologist, and are often discovered incidentally during evaluation for other gynecologic, gastrointestinal or urologic pathologies. We report the presentation of a patient with multiple accessory ovaries in addition to a rare congenital anomaly of the splanchnic vasculature called an Abernethy malformation. Read More

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December 2018

Combination of Ga-PSMA PET/CT and multiparameter MRI improves the detection of clinically significant prostate cancer: a lesion by lesion analysis.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, China.

To explore whether Ga-PSMA PET/CT (PET/CT) or the combination of mpMRI and Ga-PSMA PET/CT (com-MRI/PET) can improve the detection of csPCa. We retrospectively enrolled 54 patients who underwent both mpMRI and PET/CT before radical prostatectomy. Regions of interest (ROI) on imaging from mpMRI, PET/CT and pathology were marked. Read More

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December 2018

A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates.

PLoS One 2018 14;13(12):e0209038. Epub 2018 Dec 14.

Department of Clinical Microbiology, Virology, and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden.

Human adenoviruses (HAdVs) are common pathogens that can cause respiratory, gastrointestinal, urogenital, and ocular infections. They are divided into seven species containing 85 genotypes. Straightforward typing systems might help epidemiological investigations. Read More

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December 2018

Compatibility of CO laser surgery and fluorescence detection in head and neck cancer cells.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Surgical treatment of cancer requires tumor excision with emphasis on function preservation which is achieved in (early stage) laryngeal cancer by transoral carbon dioxide (CO ) laser surgery. Whereas conventional laser surgery is restricted by the surgeon's visual recognition of tumor tissue, new approaches based on fluorescence-guided surgery (FGS) improve the detection of the tumor and its margin. However, it is unclear whether fluorophores are compatible with high-power laser application or whether precision is compromised by laser-induced bleaching of the dye. Read More

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December 2018
1 Read

Editorial Comment to Long-term safety and efficacy of antimuscarinic add-on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study).

Authors:
Takeya Kitta

Int J Urol 2018 Dec 13. Epub 2018 Dec 13.

Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

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December 2018

SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathway.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China.

Oxidative stress is important for the calcium oxalate (CaOx)-induced kidney stone formation. Sirtuin 3 (SIRT3) plays an essential role in the amelioration of oxidative damages. This study aims to explore the effect of SIRT3 on the formation of CaOx-induced kidney stones and the underlying mechanism. Read More

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December 2018

Phase II Trial of Pure Hypofractionated Radiotherapy in the Treatment of Localized Carcinoma of the Prostate.

Cureus 2018 Oct 9;10(10):e3435. Epub 2018 Oct 9.

Radiation Oncology, Schulich School of Medicine & Dentistry - Western University, London, CAN.

Purpose To evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity and the biochemical control of pure hypofractionated radiotherapy (without acceleration) for the treatment of prostate cancer. Methods and materials This phase II prospective trial evaluated low-risk and intermediate-risk prostate cancer patients who received hypofractionated radiotherapy. Fifty-three patients with low-risk prostate cancer received 50 Gy in 15 fractions, 156 patients with intermediate-risk prostate cancer received 60 Gy in 20 fractions over eight weeks. Read More

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October 2018

Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer.

Oncoimmunology 2019 1;8(1):e1486953. Epub 2018 Oct 1.

Division of Hematology and Oncology, University of California, San Francisco, CA, USA.

Sipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood. We have previously shown that this treatment can induce the recruitment of CD4 and CD8 T cells to the tumor microenvironment. Read More

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October 2018

Genetic associations of T cell cancer immune response with tumor aggressiveness in localized prostate cancer patients and disease reclassification in an active surveillance cohort.

Oncoimmunology 2019 29;8(1):e1483303. Epub 2018 Oct 29.

Departments of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Determining prostate cancer (PCa) aggressiveness and reclassification are critical events during the treatment of localized disease and for patients undergoing active surveillance (AS). Since T cells play major roles in cancer surveillance and elimination, we aimed to identify genetic biomarkers related to T cell cancer immune response which are predictive of aggressiveness and reclassification risks in localized PCa. The genotypes of 3,586 single nucleotide polymorphisms (SNPs) from T cell cancer immune response pathways were analyzed in 1762 patients with localized disease and 393 who elected AS. Read More

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October 2018

Cancers among adolescents and young adults at one institution in Japan.

Oncol Lett 2018 Dec 1;16(6):7212-7222. Epub 2018 Oct 1.

Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

Adolescents and young adults (AYAs) with cancer often live long lives following treatment and face many life events. No detailed studies of cancers in AYAs have described the epidemiology, treatment outcome, and social status in Japan. The present study defined AYAs as those aged 15-29 years old based on the US National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program. Read More

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December 2018

Extracting tumour prognostic factors from a diverse electronic record dataset in genito-urinary oncology.

Int J Med Inform 2019 Jan 23;121:53-57. Epub 2018 Oct 23.

Austin Health, Department of Radiation Oncology, Melbourne, Australia; Department of Cancer Medicine, Latrobe University, Melbourne, Australia.

Objectives: To implement a system for unsupervised extraction of tumor stage and prognostic data in patients with genitourinary cancers using clinicopathological and radiology text.

Methods: A corpus of 1054 electronic notes (clinician notes, radiology reports and pathology reports) was annotated for tumor stage, prostate specific antigen (PSA) and Gleason grade. Annotations from five clinicians were reconciled to form a gold standard dataset. Read More

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January 2019
1 Read

Evaluation of an educational intervention to increase HIV-testing in high HIV prevalence general practices: a pilot feasibility stepped-wedged randomised controlled trial.

BMC Fam Pract 2018 Dec 13;19(1):195. Epub 2018 Dec 13.

Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.

Background: HIV-infected patients often present to primary care several times with HIV-indicator conditions before diagnosis but the opportunity to test by healthcare professionals (HCPs) is frequently missed. Current HIV testing rates in primary care are low and educational interventions to facilitate HCPs to increase testing and awareness of HIV are needed.

Method: We implemented a pilot feasibility stepped-wedged randomised controlled trial of an educational intervention in high HIV prevalence practices in Bristol. Read More

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December 2018
1 Read

Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Nat Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

In the version of this Article originally published, the authors inadvertently included the term 'pericytic mimicry' in relation to ref. 54. This has now been corrected by inserting an additional reference at position 51 and amending the text in the Discussion relating to 'pericytic mimicry', ref. Read More

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December 2018

Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population.

Prostate Cancer Prostatic Dis 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Background: Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency of BRCA1 and BRCA2 (BRCA1/2) gene alterations was recently reported in metastatic castration-resistant PCa specimens. Mutations in BRCA2 vary in racial and ethnic groups including African-American (AA) and Caucasian-American (CA) populations.

Methods: BRCA1 and BRCA2 genes were sequenced (Ion AmpliSeq targeted sequencing) in archived blood DNA specimens in 1240 PCa patients, including 30% AA patients, in three different cohorts: localized early stage (T2) PCa (N = 935); advanced PCa (50% T3-4) (N = 189); and metastatic PCa (N = 116). Read More

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December 2018

Acetylation drives hepatocyte nuclear factor 1β stability by blocking proteasome-mediated degradation.

J Cell Biochem 2018 Dec 7. Epub 2018 Dec 7.

CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, Lisboa, Portugal.

Hepatocyte nuclear factor 1β (HNF1β) is mostly expressed in the liver, but is also expressed in other organs, like kidney, pancreas and genitourinary tract. In fact, HNF1β, a member of the superfamily of homeodomain-containing transcription factors, has been described as a hallmark in clear cell carcinomas. However, its role as an oncogene or as tumor suppressor gene remains controversial. Read More

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December 2018

IUGA committee opinion: laser-based vaginal devices for treatment of stress urinary incontinence, genitourinary syndrome of menopause, and vaginal laxity.

Int Urogynecol J 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, The American University of Beirut, Beirut, Lebanon.

This committee opinion reviews the laser-based vaginal devices for treatment of genitourinary syndrome of menopause, vaginal laxity, and stress urinary incontinence. The United States Food and Drug Administration has issued a warning for unsubstantiated advertising and use of energy-based devices. Well-designed case-control studies are required to further investigate the potential benefits, harm, and efficacy of laser therapy in the treatment of genitourinary syndrome of menopause, vaginal laxity, and stress urinary incontinence. Read More

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December 2018

Paratesticular rhabdomyosarcoma mimicking complicated epididymal cyst.

J Cancer Res Ther 2018 Dec;14(Supplement):S1241-S1243

Department of Urology, Faculty of Medicine, Kemerburgaz University, Medical Park Bursa Hospital, Bursa, Turkey.

Paratesticular rhabdomyosarcoma (RMS) is a rare nongerm cell intrascrotal malignant tumor in children and young adult/teens resulting from the mesenchymal tissues of the tunica vaginalis, epididymis, spermatic cord, and testis. RMS accounts for approximately 7% of all genitourinary tract RMSs and 12% of all pediatric scrotal neoplasms. Patients usually present with a painless unilateral scrotal mass. Read More

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December 2018

Biobanking of Urine Samples.

Authors:
Neda A Moatamed

Methods Mol Biol 2019 ;1897:115-124

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Urine is a major repository of biometabolites, some proteins, and DNA. Within the past few decades, it has become increasingly apparent that certain infectious, neoplastic, and congenital diseases can be investigated using urine samples for diagnostic and prognostic purposes. In this chapter, a number of pertinent urine analytes and methods of banking urine samples for future analyses are discussed. Read More

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January 2019
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Estradiol vaginal inserts (Imvexxy): effective in genitourinary syndrome of menopause without increasing systemic estrogen levels.

Authors:
D M Paton

Drugs Today (Barc) 2018 Nov;54(11):667-677

Professor Emeritus of Pharmacology, University of Auckland, Auckland, New Zealand.

Many women suffer from the genitourinary syndrome of the menopause (GSM), in particular pathological changes that occur in the vagina due to the reduction in their production of estrogens. TherapeuticsMD has developed Imvexxy, small softgel capsules that contain solubilized estradiol and that are inserted vaginally by women twice a week, every 3 to 4 days. These vaginal inserts have been found to readily supply estradiol to the vagina and to result in significant improvement in the GSM signs and symptoms these women had been experiencing. Read More

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November 2018

Combination therapy for advanced and metastatic kidney cancer.

Nat Rev Urol 2018 Dec 11. Epub 2018 Dec 11.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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December 2018

Prostate Cancer Risk-Associated Single-Nucleotide Polymorphism Affects Prostate-Specific Antigen Glycosylation and Its Function.

Clin Chem 2018 Dec 11. Epub 2018 Dec 11.

Australian Prostate Cancer Research Centre-Queensland and Cancer Program, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

Background: Genetic association studies have reported single-nucleotide polymorphisms (SNPs) at chromosome 19q13.3 to be associated with prostate cancer (PCa) risk. Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 () gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk ( = 2. Read More

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December 2018

Outcomes and prognostic factors in intermediate-risk prostate cancer: multi-institutional analysis of the Spanish RECAP database.

Clin Transl Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiation Oncology, Instituto Valenciano de Oncologia, Alcoy, Spain.

Purpose: To retrospectively assess outcomes and to identify prognostic factors in patients diagnosed with intermediate-risk (IR) prostate cancer (PCa) treated with primary external beam radiotherapy (EBRT).

Materials And Methods: Data were obtained from the multi-institutional Spanish RECAP database, a population-based prostate cancer registry in Spain. All IR patients (NCCN criteria) who underwent primary EBRT were included. Read More

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December 2018
1 Read

Empiric Antibiotic Treatment Thresholds for Serious Bacterial Infections: A Scenario-Based Survey Study.

Clin Infect Dis 2018 Dec 7. Epub 2018 Dec 7.

Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Canada.

Background: Physicians face competing demands of maximizing pathogen coverage, while minimizing unnecessary use of broad-spectrum antibiotics when managing sepsis. We sought to identify physicians' perceived likelihood of coverage achieved by their usual empiric antibiotic regimen, along with minimum thresholds of coverage they would be willing to accept when managing these patients.

Methods: We conducted a scenario-based survey of internal medicine physicians from across Canada using a 2 x 2 factorial design, varied by infection source (undifferentiated vs. Read More

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December 2018

De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders.

PLoS Genet 2018 Dec 10;14(12):e1007822. Epub 2018 Dec 10.

Department of Systems Biology, Columbia University Medical Center, New York, New York, United States of America.

Congenital diaphragmatic hernia (CDH) is a severe birth defect that is often accompanied by other congenital anomalies. Previous exome sequencing studies for CDH have supported a role of de novo damaging variants but did not identify any recurrently mutated genes. To investigate further the genetics of CDH, we analyzed de novo coding variants in 362 proband-parent trios including 271 new trios reported in this study. Read More

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December 2018

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.

Oncogene 2018 Dec 7. Epub 2018 Dec 7.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition a promising therapeutic strategy for cancer treatment. To identify genes whose loss makes tumor cells hypersensitive to ATR inhibition, we performed CRISPR/Cas9-based whole-genome screens in 3 independent cell lines treated with a highly selective ATR inhibitor, AZD6738. These screens uncovered a comprehensive genome-wide profile of ATR inhibitor sensitivity. Read More

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December 2018

Histopathologic False-positive Diagnoses of Prostate Cancer in the Age of Immunohistochemistry.

Am J Surg Pathol 2018 Dec 7. Epub 2018 Dec 7.

Department of Cellular Pathology, Barts Health NHS Trust.

There are few studies into the rate and causes of histopathologic false-positive diagnosis of prostate cancer. Only 2 of these, including a previous one from our group, incorporate survival data. In addition, in none of the previous studies had immunohistochemistry (IHC) been originally requested on any of the misdiagnosed cases. Read More

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December 2018

Can the use of probiotics in association with isoflavone improve the symptoms of genitourinary syndrome of menopause? Results from a randomized controlled trial.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, State University of Campinas (UNICAMP - Universidade Estadual de Campinas), Campinas, São Paulo, Brazil.

Objective: To evaluate the effect of isoflavone administration, either in conjunction with probiotic use or not, on the symptoms of genitourinary syndrome of menopause, and compare the effects with those of hormone therapy.

Methods: A randomized clinical trial was conducted on 60 postmenopausal women aged 40 to 60 years, randomly assigned to receive oral isoflavone (150 mg dry extract of glycine max) alone or isoflavone plus probiotic (Lactobacillus acidophilus, Lactobacillus casei, Lactococcus lactis, Bifidobacterium bifidum, and Bifidobacterium lactis) or hormone therapy (1 mg estradiol and 0.5 mg norethisterone acetate). Read More

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December 2018

Women's experience of vulvovaginal symptoms associated with menopause.

Menopause 2018 Dec 10. Epub 2018 Dec 10.

New England Research Institutes, Inc., Watertown, MA.

Objective: This study describes women's experiences of the genitourinary syndrome of menopause (GSM) elicited through focus groups and cognitive debriefing sessions during development of a novel patient-reported outcome measure (PROM) designed for use in both clinical care and research.

Methods: A draft questionnaire to identify and assess bothersome genitourinary symptoms associated with estrogen deficiency in menopausal women was developed in five discrete phases from multiple sources of information in accordance with standards for PROM development. GSM was confirmed by report of symptoms in conjunction with a confirmatory pelvic examination and laboratory assessments. Read More

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December 2018

Correlation of ultrasonically determined bladder wall thickness and prostatic calcification with the UPOINT scoring system.

Urology 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Hitit University School of Medicine, Corum, Turkey.

Objective: To evaluate ultrasonically determined bladder wall thickness (BWT) and prostatic calcification presence, in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and to correlate the findings with patient characteristics and the UPOINT classification system.

Material And Methods: Between January 2008 and December 2017 data of 1294 patients diagnosed with chronic prostatitis, in a single urology clinic, meeting a number of selective inclusion/exclusion criterias, were retrospectively analyzed. Patients, compliant to fill out all requested questionnaires, between the ages of 21-65 years were included to the study. Read More

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December 2018
2 Reads

Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint.

Eur Urol 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine, Genitourinary Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Bone metastases in patients with metastatic castration-resistant prostate cancer (mCRPC) are associated with debilitating pain and functional compromise.

Objective: To compare pain palliation as the primary endpoint for cabozantinib versus mitoxantrone-prednisone in men with mCRPC and symptomatic bone metastases using patient-reported outcome measures.

Design, Setting, And Participants: A randomized, double-blind phase 3 trial (COMET-2; NCT01522443) in men with mCRPC and narcotic-dependent pain from bone metastases who had progressed after treatment with docetaxel and either abiraterone or enzalutamide. Read More

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December 2018

Urinary metabolic abnormalities in children with idiopathic hematuria.

J Pediatr Urol 2018 Nov 10. Epub 2018 Nov 10.

Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Hematuria, either macroscopic or microscopic, is an incidental finding of multiple nephrologic or urologic disorders. Disturbances of urine inhibitors or promotors have been suggested as the potential causes of isolated idiopathic hematuria in children and its recurrence. Meanwhile, appropriate treatment of these risk factors might improve secondary asymptomatic or macroscopic hematuria. Read More

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November 2018

The oncological outcomes of small cell carcinoma of the bladder.

Can Urol Assoc J 2018 Dec 3. Epub 2018 Dec 3.

Department of Surgery, Division of Urology, University of Western Ontario, London, ON, Canada.

Introduction: Small cell carcinoma of the bladder (SmCC) is a rare and aggressive genitourinary malignancy. The paucity of clinical trials and outcome data provide no standard treatment guidelines. Accordingly, patient prognosis is poor. Read More

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December 2018

Complications of Intravesical BCG Immunotherapy for Bladder Cancer.

Radiographics 2018 Dec 7:180014. Epub 2018 Dec 7.

From the Department of Radiology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 E. 68th St, Box 141, New York, NY 10065 (D.B.G.); Department of Radiology, Mayo Clinic Arizona, Scottsdale, Ariz (A.K.) and Phoenix, Ariz (C.O.M.); Department of Radiology, Okayama University Hospital, Okayama, Japan (T.T.); Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY (G.R.S.); Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (S.B.); Departments of Radiology and Medicine, Zucker School of Medicine at Hofstra Northwell, North Shore University Hospital, Manhasset, NY (R.S.); and Department of Radiology, Mayo Clinic, Rochester, Minn (B.F.K.).

Bladder cancer is the sixth most common cancer in the United States, and 70% of cases are non-muscle invasive. Intravesical bacillus Calmette-Guérin (BCG) immunotherapy, administered after transurethral tumor resection, is the most effective adjuvant treatment for intermediate- and high-grade non-muscle-invasive bladder cancer. Despite its weakened state, BCG has the potential to cause multisystem disease in treated patients. Read More

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December 2018

Dramatic polarization in genitourinary expert opinions regarding the clinical utility of positron emission tomography (PET) imaging in prostate cancer.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Objectives: To ascertain the opinions of North American genitourinary (GU) experts regarding inclusion of technologies such as prostate - specific membrane antigen (PSMA) and C - 11 choline positron emission tomography (PET) into routine practice.

Materials And Methods: A survey was distributed to North American GU experts. Questions pertained to the role of PSMA and C - 11 PET in PCa management. Read More

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October 2018
2 Reads

Re: Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Reconstructive Urology, St Helens & Knowsley Hospital NHS Trust Whiston Hospital, Liverpool, United Kingdom.

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October 2018
2 Reads

Medical resource utilization of abiraterone acetate plus prednisone added to androgen deprivation therapy in metastatic castration-naive prostate cancer: Results from LATITUDE.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

BC Cancer-Vancouver Centre, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Abiraterone acetate plus prednisone (AA+P), when added to androgen deprivation therapy (ADT), demonstrated significant improvements in overall survival and disease progression over dual placebos added to ADT in the LATITUDE clinical trial (NCT01715285). The objective of this study was to assess event-driven medical resource utilization (MRU) of ADT plus AA+P (ADT+AA+P) versus ADT plus dual placebos (ADT+placebos) in LATITUDE.

Methods: Event-driven MRU data from LATITUDE while patients were on treatment were used for analyses. Read More

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December 2018
5 Reads

Role of epithelial-to-mesenchymal transition in inflammatory bowel disease.

J Crohns Colitis 2018 Dec 6. Epub 2018 Dec 6.

IBD Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy.

Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease (IBD), occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition (EMT) represents an embryonic program relaunched during wound healing, fibrosis and cancer. Read More

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December 2018
5 Reads

Platelet transfusion practices in immune thrombocytopenia related hospitalizations.

Transfusion 2018 Dec 5. Epub 2018 Dec 5.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Division of Hematology/Oncology, Emory University School of Medicine, Atlanta, Georgia.

Background: The role of platelet transfusions in management of Immune Thrombocytopenia (ITP) remains controversial. Current guidelines recommend that platelet transfusions in ITP be reserved for catastrophic hemorrhage or invasive surgical procedures. This study assesses the nationwide platelet transfusion practices in hospitalized children and adults with ITP. Read More

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December 2018
5 Reads

High expression of TFEB is associated with aggressive clinical features in colorectal cancer.

Onco Targets Ther 2018 13;11:8089-8098. Epub 2018 Nov 13.

Department of Internal Medicine, Tianjin Binhai New Area Dagang Hospital, Tianjin 300270, China.

Objectives: The transcription factor EB (TFEB), a member of the micropthalmia family, has been found to be associated with autophagy and upregulated in some kinds of tumors. However, very few studies focused on TFEB in colorectal cancer (CRC). TFEB expression status and its relevance to clinical features in CRC would be analyzed in this study. Read More

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November 2018
1 Read

Household structure and its association with sexual risk behaviours and sexual health outcomes: evidence from a British probability sample survey.

BMJ Open 2018 Dec 4;8(12):e024255. Epub 2018 Dec 4.

Centre for Population Research in Sexual Health and HIV, Institute for Global Health, University College London, London, UK.

Objectives: Economic and social changes over the last 20 years have led to changes in the living situations of young people in Britain. A person's home-life context might influence their sexual behaviour, with implications for their sexual healthcare needs; we investigated this hypothesis.

Methods: Britain's third National Survey of Sexual Attitudes and Lifestyles, a probability sample survey undertaken in 2010-2012, interviewed 15 162 men and women aged 16-74 years in Britain (with 3869 aged 16-24 years). Read More

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December 2018

Consensus on molecular imaging and theranostics in prostate cancer.

Lancet Oncol 2018 Dec;19(12):e696-e708

Department of Nuclear Medicine, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Nuclear Medicine, The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, London, UK.

Rapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. To tackle this problem, international experts representing medical oncologists, urologists, radiation oncologists, radiologists, and nuclear medicine specialists convened at the European Association of Nuclear Medicine Focus 1 meeting to deliver a balanced perspective on available data and clinical experience of imaging in prostate cancer, which had been supported by a systematic review of the literature and a modified Delphi process. Relevant conclusions included the following: diphosphonate bone scanning and contrast-enhanced CT are mentioned but rarely recommended for most patients in clinical guidelines; MRI (whole-body or multiparametric) and prostate cancer-targeted PET are frequently suggested, but the specific contexts in which these methods affect practice are not established; sodium fluoride-18 for PET-CT bone scanning is not widely advocated, whereas gallium-68 or fluorine-18 prostate-specific membrane antigen gain acceptance; and, palliative treatment with bone targeting radiopharmaceuticals (rhenium-186, samarium-153, or strontium-89) have largely been replaced by radium-223 on the basis of the survival benefit that was reported in prospective trials, and by other systemic therapies with proven survival benefits. Read More

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December 2018
3 Reads

An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy.

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908.

Background: B cells play a critical role in the development and maintenance of food allergy by producing allergen-specific IgE. Despite the importance of B cells in IgE-mediated food allergy, the identity of sIgE-producing human B cells and how IgE is regulated are poorly understood.

Objective: To identify the immunophenotypes of circulating B cells associated with the production of galactose-alpha-1,3-galactose specific IgE production in patients with red meat allergy. Read More

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December 2018

Understanding risk and refining surveillance following tumor resection for low grade non-muscle invasive bladder cancer.

Transl Androl Urol 2018 Dec;7(6):987-989

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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December 2018
1 Read

Sexual dysfunction and infertility in the male spina bifida patient.

Transl Androl Urol 2018 Dec;7(6):941-949

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.

Spina bifida is a congenital neural tube defect with many neurological implications, as well as decreased sexual function and infertility. Few studies have directly investigated infertility in men with spina bifida. Infertility in this special patient population is primarily the result of spermatogenic defects and/or failure of sperm transport due to erectile or ejaculatory dysfunction. Read More

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December 2018
2 Reads

Metastatic inflammatory myofibroblastic tumor of the bladder.

Urol Case Rep 2019 Mar 15;23:10-12. Epub 2018 Nov 15.

Department of Surgery - Division of Urology, 1 Hospital Drive, MC 301E, Columbia, MO, 65212, USA.

A 61-year-old male presented with gross hematuria and transurethral resection of bladder tumor revealed inflammatory myofibroblastic tumor (IMT). Due to extent of disease leading to ureteral obstruction and hydronephrosis, radical cystectomy (RC) with ileal conduit urinary diversion was performed. Five months after RC, the patient presented with decreased urine output. Read More

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March 2019
1 Read

DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.

Am J Hum Genet 2018 Dec 29;103(6):1038-1044. Epub 2018 Nov 29.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations in POLE, encoding the Pol ε catalytic subunit POLE1, in 15 individuals from 12 families. Phenotypically, these individuals had clinical features closely resembling IMAGe syndrome (intrauterine growth restriction [IUGR], metaphyseal dysplasia, adrenal hypoplasia congenita, and genitourinary anomalies in males), a disorder previously associated with gain-of-function mutations in CDKN1C. Read More

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December 2018
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Response to the recently published UK National Guideline on the Sexual Health Care of Men who Have Sex with Men.

Int J STD AIDS 2018 Nov 30:956462418813070. Epub 2018 Nov 30.

Department of Genitourinary Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK.

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November 2018

Cardiovascular Manifestations of Erdheim-Chester's Disease: A Case Series.

Arq Bras Cardiol 2018 Dec;111(6):852-855

Instituto do Câncer do Estado de São Paulo, São Paulo, SP - Brazil.

Erdheim-Chester Disease is a rare entity, classified as an inflammatory myeloid neoplasm, with an unknown incidence, occurring preferentially in men after 50 years of age. Classically, it has a multisystemic presentation, with the skeletal system being the most frequently affected (90% of the patients), followed by genitourinary involvement in 60% of cases and central nervous system in the pituitary and diabetes insipidus in 25% of the cases. Cardiovascular manifestations are present in more than half of the patients, with aortic infiltration and atrial pseudotumor being the most common forms. Read More

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December 2018
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