7,190 results match your criteria Genital Warts


Long-term immunogenicity, effectiveness, and safety of nine-valent human papillomavirus vaccine in girls and boys 9 to 15 years of age: Interim analysis after 8 years of follow-up.

Papillomavirus Res 2020 Jul 10:100203. Epub 2020 Jul 10.

Merck & Co Inc., Kenilworth, NJ, USA. Electronic address:

Background: The nine-valent human papillomavirus (9vHPV) vaccine protects against infection and disease related to HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. The pivotal 36-month Phase III immunogenicity study of 9vHPV vaccine in 9- to 15-year-old girls and boys was extended to assess long-term immunogenicity and effectiveness through approximately 10 years after vaccination. We describe results of an interim analysis based on approximately 8 years of follow-up after vaccination. Read More

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http://dx.doi.org/10.1016/j.pvr.2020.100203DOI Listing

Topical Imiquimod for Management of Recurrent Lentigo Maligna Melanoma in Situ.

Acta Dermatovenerol Croat 2020 Jul;28(1):34-37

Professor Igor Bartenjev, MD, PhD, Department of Dermatovenerology, Medical faculty, University of Ljubljana, Pod kostanji 4, 1000 Ljubljana, Slovenia;

Topical imiquimod is a medication approved for the treatment of external genital and perianal warts, actinic keratosis, and superficial basal cell carcinoma. There have also been reports of its successful use in patients with lentigo maligna melanoma in situ. An 80-year-old female patient was diagnosed with lentigo maligna melanoma in situ which was then surgically removed. Read More

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Genome-wide identification of methylated CpG sites in nongenital cutaneous warts.

BMC Med Genomics 2020 Jul 8;13(1):100. Epub 2020 Jul 8.

Department of Internal Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Background: Low-risk HPV infection has not been the subject of epigenetic investigation. The present study was carried out in order to investigate the methylation status of CpG sites in non-genital cutaneous warts.

Methods: Genomic DNA was extracted from 24 paired epidermal samples of warts and normal skin. Read More

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http://dx.doi.org/10.1186/s12920-020-00745-6DOI Listing

Comparison between anal cytology, high-resolution anoscopy and HPV DNA genotyping by polymerase chain reaction in the post-treatment follow-up of condylomata acuminata.

Rev Col Bras Cir 2020 3;47:e20202543. Epub 2020 Jul 3.

Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brasil.

Aim: to evaluate the presence of subclinical HPV-induced anal lesions with anal cytology, High-Resolution Anoscopy (HRA) and HPV genotyping by polymerase chain reaction (PCR) in the follow-up of treated condylomata acuminata (CA).

Methods: seventy-nine male patients were included. One month after anal CA eradication, the patients underwent brush samples collection for anal cytology and PCR, and HRA with biopsy of acetowhite lesions. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202543DOI Listing

Modified photodynamic therapy to minimize pain in the treatment of condylomata acuminata: a prospective, randomized, self-controlled study.

Photodiagnosis Photodyn Ther 2020 Jul 4:101915. Epub 2020 Jul 4.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Pain is a major concern associated with conventional photodynamic therapy (C-PDT).

Objective: To evaluate the efficacy, pain and safety of modified photodynamic therapy(M-PDT) for the treatment of condylomata acuminata.

Methods: A prospective, randomized, self-controlled study was conducted. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101915DOI Listing

Analysis of dermatologic conditions in Turkey and Italy by using Google Trends analysis in the era of the COVID-19 pandemic.

Authors:
Ömer Kutlu

Dermatol Ther 2020 Jul 2:e13949. Epub 2020 Jul 2.

School of Medicine, Department of Dermatology and Venereology, Uşak University, Turkey.

Many areas of life including patterns of dermatological diseases that patient attend to the hospital were tremendously affected by implementing stay-at-home orders during the COVID-19 pandemic. We aimed to identify the dermatologic interest of the public during the COVID-19 pandemic by using Google Trends. The terms "acne", "hair loss", "eczema", "genital warts", "molluscum contagiosum", "botox", "skin cancer", "sunscreen" were analyzed on first April, first May, first June 2020, and the corresponding period of the previous year in Turkey and Italy by using Google Trends. Read More

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http://dx.doi.org/10.1111/dth.13949DOI Listing

Do Male University Students Know Enough About Human Papillomavirus (HPV) to Make Informed Decisions About Vaccination?

Med Sci Monit 2020 Jun 30;26:e924840. Epub 2020 Jun 30.

Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China (mainland).

BACKGROUND The aim of this study was to evaluate the awareness of human papillomavirus (HPV), knowledge of HPV-associated diseases, as well as willingness to undergo HPV vaccination among male university students in China, especially factors influencing vaccination willingness. MATERIAL AND METHODS We conducted a cross-sectional study among university students in Beijing, Tianjin, and Hebei, China by using a convenience sampling method. We assessed a) the awareness of HPV, b) knowledge of HPV-associated diseases, c) willingness to undergo HPV vaccination, and d) sexual behaviors among male university students. Read More

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http://dx.doi.org/10.12659/MSM.924840DOI Listing

Defining Elimination of Genital Warts-A Modified Delphi Study.

Vaccines (Basel) 2020 Jun 18;8(2). Epub 2020 Jun 18.

The Kirby Institute, UNSW Sydney, New South Wales 2052, Australia.

Substantial declines in genital warts (GW) have been observed in countries with quadrivalent HPV vaccination programmes, with Australia showing the highest reductions due to early commencement and high vaccination coverage. There is a real potential to achieve GW elimination; however, no GW elimination definition exists. Taking Australia as a case study, we aimed to reach expert consensus on a proposed GW elimination definition using a modified Delphi process. Read More

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http://dx.doi.org/10.3390/vaccines8020316DOI Listing

[The consensus of the Portuguese Society of Andrology, Sexual Medicine and Reproduction on Male HPV: diagnosis].

Rev Int Androl 2020 Jun 18. Epub 2020 Jun 18.

Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução (SPA), Lisboa, Portugal; Serviço de Urologia do Hospital da Luz Arrábida, Porto, Portugal.

HPV infection affects about 50% of sexually active individuals at least once in a lifetime. Diagnosis is made on careful inspection of the genital area and can be divided into benign lesions (genital warts or condyloma acuminatum) and pre-malignant lesions (intraepithelial neoplasia) that can lead to cancer (invasive neoplasia). Diagnostic recommendations are reviewed in Male, Female, Couple and in the immunocompromised host. Read More

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http://dx.doi.org/10.1016/j.androl.2019.11.004DOI Listing

Impact of a single-age cohort human papillomavirus vaccination strategy in Catalonia, Spain: Population-based analysis of anogenital warts in men and women.

Prev Med 2020 Sep 18;138:106166. Epub 2020 Jun 18.

Unit of Infections and Cancer - Information and Interventions, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO) - IDIBELL, l'Hospitalet de Llobregat, Spain. Electronic address:

Extensive multiple-age cohort human papillomavirus (HPV) vaccination has proved to be highly effective. We aimed to determine the 8-year population impact of a female single-age cohort HPV vaccination programme on the incidence of anogenital warts (AGW). In 2008, Catalonia initiated a school-based quadrivalent HPV vaccination programme targeting 11-year-old girls, achieving coverage over 80%. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106166DOI Listing
September 2020

Risk of anal high-grade squamous intraepithelial lesions among renal transplant recipients compared with immunocompetent controls.

Clin Infect Dis 2020 Jun 16. Epub 2020 Jun 16.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Background: Renal transplant recipients (RTRs) have increased risk of human papillomavirus (HPV)-related cancers, including anal cancer. We investigated the prevalence of anal high-grade intraepithelial lesions (HSIL) in RTRs compared with immunocompetent controls and risk factors for anal HSIL in RTRs.

Methods: We included 247 RTRs and 248 controls in this cross-sectional study. Read More

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http://dx.doi.org/10.1093/cid/ciaa781DOI Listing

CD4 trajectory models and onset of non-AIDS defining anal genital warts, pre-cancer, and cancer in PLWH.

Sex Transm Dis 2020 Jun 10. Epub 2020 Jun 10.

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35242.

Background: It is unclear how the characteristics of CD4 counts predict non-AIDS defining (NAD) HPV-related ano-genital warts (AGW) and anal high-grade squamous intraepithelial lesions/cancer (HSIL) in PLWH. We compared the associations between 3 CD4 counts measures and these disease outcomes in the study.

Methods: Retrospective socio-behavioral and clinical data from electronic health records of 4,803 PLWH from 2006-2018 were included. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001215DOI Listing

Carbon dioxide (CO) laser ablation treatment of a peri-urethral genital wart: A case report.

Case Rep Womens Health 2020 Jul 26;27:e00226. Epub 2020 May 26.

School of Medicine, Texas Tech University Health Sciences Center (TTUHSC) at the Permian Basin, TX, USA.

Background: Visible genital warts are caused by the nearly 100 recognized strains of human papillomavirus (HPV). HPV infections caused by high-risk strains are associated with significant morbidity and mortality rates. Genital warts are diagnosed by visual inspection and treated by three major methods: topical agents, systemic agents, and surgical therapies. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283141PMC

Risk of Virus Contamination Through Surgical Smoke During Minimally Invasive Surgery: A Systematic Review of the Literature on a Neglected Issue Revived in the COVID-19 Pandemic Era.

Eur Urol Focus 2020 Jun 5. Epub 2020 Jun 5.

Department Surgery, Oncology and Gastroenterology, Urologic Unit, University of Padova, Padova, Italy. Electronic address:

Context: The coronavirus disease 2019 (COVID-19) pandemic raised concerns about the safety of laparoscopy due to the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diffusion in surgical smoke. Although no case of SARS-CoV-2 contagion related to surgical smoke has been reported, several international surgical societies recommended caution or even discouraged the use of a laparoscopic approach.

Objective: To evaluate the risk of virus spread due to surgical smoke during surgical procedures. Read More

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http://dx.doi.org/10.1016/j.euf.2020.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274598PMC

Nonavalent human papillomavirus vaccination as alternative treatment for genital warts.

Dermatol Ther 2020 Jun 4:e13771. Epub 2020 Jun 4.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Genital warts caused by the human papillomavirus (HPV) are the most common sexually transmitted disease and have a negative impact on quality of life. Of the more than 200 different types of HPV, low-risk types 6 and 11 are mainly responsible for the development of condyloma acuminata. Despite a large arsenal of local therapies such as numerous topical agents, CO laser ablation, and surgical removal, genital warts tend to be recalcitrant. Read More

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http://dx.doi.org/10.1111/dth.13771DOI Listing

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers.

Molecules 2020 Jun 2;25(11). Epub 2020 Jun 2.

Tea Solutions, Hara Office Inc. Tokyo 130-0012, Japan.

Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Read More

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http://dx.doi.org/10.3390/molecules25112588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321293PMC

Successful management of giant condyloma acuminatum of vulva with combination of surgical and photodynamic therapy: report of two cases.

Photodiagnosis Photodyn Ther 2020 May 29:101847. Epub 2020 May 29.

Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha 410011, China. Electronic address:

Patients with condylomata acuminata of the vulva usually have an increased difficulty for treatments and a higher risk of disease recurrence. Treatments for this disease varies, including surgical excision, cryotherapy, electrocautery, CO2 laser therapy, topical therapy, and photodynamic therapy (PDT), but none of these provides a satisfactory outcome in most refractory cases, especially for giant condyloma acuminatum (GCA). We reported two cases of GCA successfully cured with surgical removal, electrocautery and photodynamic therapy. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101847DOI Listing

The quadrivalent HPV vaccine is protective against genital warts: a meta-analysis.

BMC Public Health 2020 May 28;20(1):691. Epub 2020 May 28.

Department of Public Health, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary.

Background: The quadrivalent human papillomavirus (HPV) vaccine has been assumed to give protection against genital warts (GW) as well as cervical cancer. Our main question was whether HPV vaccine has any effects on the prevention of GW reported in randomised controlled clinical trials (RCTs) and time-trend analyses.

Methods: This meta-analysis was performed according to the PRISMA guidelines using the PICO format. Read More

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http://dx.doi.org/10.1186/s12889-020-08753-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254696PMC

Could the human papillomavirus vaccine prevent recurrence of ano-genital warts?: a systematic review and meta-analysis.

Int J STD AIDS 2020 Jun 21;31(7):606-612. Epub 2020 May 21.

Department of Dermatology and Venereology, Hospital de Baza, Granada, Spain.

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide and ano-genital warts (AGWs) are highly infectious. This virus is transmitted through sexual, anal, or oral contact as well as skin-to-skin contacts. Treatment for this condition has significant morbidity and it can be frustrating in certain cases. Read More

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http://dx.doi.org/10.1177/0956462420920142DOI Listing

Atypical presentation of genital molluscum contagiosum mimicking genital warts.

Int J STD AIDS 2020 May 21:956462420920410. Epub 2020 May 21.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A man in his 20s with a history of unprotected sex with a commercial sex worker three months before presented with a solitary slowly-growing, well-defined, non-tender, oval, verrucous lesion on the mucosal aspect of his prepuce. Dermoscopy revealed a polylobular, pinkish-white, amorphous structure in the centre with a surrounding crown of vessels that did not cross the centre of the lobules, and histopathology showed keratinocytes containing intracytoplasmic faintly granular eosinophilic inclusions and peripherally-pushed nuclei. A diagnosis of agminated genital molluscum contagiosum was reached on the basis of the above findings. Read More

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http://dx.doi.org/10.1177/0956462420920410DOI Listing
May 2020
1.037 Impact Factor

Successful topical treatment of anal giant condylomata acuminata in an infant.

Dermatol Ther 2020 May 19:e13624. Epub 2020 May 19.

Dermatology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Anogenital condylomata acuminata are induced by human papillomavirus (HPV) and they rarely manifest in immunocompetent children. Therapeutic options depend on patient's age and general conditions and extension of the lesions. However, management is still a challenge and recurrences are frequent. Read More

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http://dx.doi.org/10.1111/dth.13624DOI Listing

Self-efficacy and HPV Vaccine Attitudes Mediate the Relationship Between Social Norms and Intentions to Receive the HPV Vaccine Among College Students.

J Community Health 2020 May 16. Epub 2020 May 16.

Department of Psychology, Purdue School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202, USA.

Human papillomavirus (HPV) has been linked to genital warts and multiple cancers affecting both men and women. Despite college students' high risk for HPV, their vaccination rates remain suboptimal. The current observational study examined the relationship between social norms and HPV vaccine intentions and potential mechanisms underlying this relationship among undergraduates. Read More

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http://dx.doi.org/10.1007/s10900-020-00837-5DOI Listing

HPV condylomatosis region treated with multiple sessions of MAL-PDT: a case report.

Photodiagnosis Photodyn Ther 2020 May 7:101812. Epub 2020 May 7.

Sao Carlos Institute of Physics, University of Sao Paulo, Brazil. Electronic address:

Condyloma or genital warts affect the tissues of the genital area due to infections induced by Human papillomavirus. There are some topical therapies indicated for condyloma lesions treatment but all of them present a high rate of recurrence. Photodynamic Therapy is proving to be an interesting strategy for treating these lesions, capable also to treat virus-infected cells on subclinical lesions. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101812DOI Listing

Non-participation in cervical cancer screening according to health, lifestyle and sexual behavior: A population-based study of nearly 15,000 Danish women aged 23-45 years.

Prev Med 2020 Aug 6;137:106119. Epub 2020 May 6.

Unit of Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Electronic address:

High participation in cervical cancer screening is essential for an effective screening program. In this population-based study, we investigated associations between general health, lifestyle and sexual behavior, and non-participation in cervical cancer screening in Denmark. During 2011-2012, a random sample of women aged 18-45 years from the general female population were invited to participate in a survey regarding health, lifestyle and sexual habits. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106119DOI Listing

Human papillomavirus-negative epithelial proliferations resembling condylomata acuminata in a patient receiving vemurafenib for Stage IV melanoma.

J Cancer Res Ther 2020 Jan-Mar;16(1):170-172

Department of Dermatology, Netherlands Cancer Institute, Amsterdam, Netherlands.

With the discovery of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, new treatment possibilities arose against metastatic melanoma. A frequent adverse effect of BRAF inhibitor therapy is the induction of epithelial proliferations such as cutaneous squamous cell carcinoma and verrucous papilloma. Here, we describe a case in which a patient developed extensive anal epithelial proliferations resembling condylomata acuminata, after starting vemurafenib treatment. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_317_17DOI Listing

Burden of HPV related anogenital diseases in young women in Germany - an analysis of German statutory health insurance claims data from 2012 to 2017.

BMC Infect Dis 2020 Apr 22;20(1):297. Epub 2020 Apr 22.

Department of Obstetrics and Gynecology, University Hospital of Duesseldorf, Duesseldorf, Germany.

Background: Most individuals are infected with human papillomavirus (HPV) at least once in their lifetime. Infections with low-risk types can cause genital warts, whereas high-risk types can cause malignant tumors. The aim of this study was to determine the burden of anogenital diseases potentially related to HPV in young women based on German statutory health insurance claims data. Read More

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http://dx.doi.org/10.1186/s12879-020-05002-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178589PMC

The Prevalence of Human Immunodeficiency Virus Infection in Patients with Sexually Transmitted Diseases.

Adv Biomed Res 2020 16;9:11. Epub 2020 Mar 16.

Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Human immunodeficiency virus (HIV) transmission pattern in Iran has been changed from injection drug to sexual contact. Lack of accurate assessment of HIV in people with sexually transmitted diseases (STDs) in Iran prompted us to conduct this study to determine the frequency of HIV infection in these patients.

Materials And Methods: In this cross-sectional study which conducted in 2016-2017, overall, 190 patients with STDs referring to two hospitals of Hamadan were enrolled in the study. Read More

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http://dx.doi.org/10.4103/abr.abr_233_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147514PMC

Anogenital Papular Lesions in Children Five Year Old and Younger: Gender Differences.

Med Arch 2020 Feb;74(1):28-33

Department of Dermatology and Venereology, the Royal Medical Services (RMS), Amman, Jordan.

Introduction: Anogenital area is a small compartment in the human body. Recognition of various dermatological conditions affecting this area in children is essential for any physician involved in pediatric examination and evaluation.

Aim: To assess the nature, diagnoses, and gender differences of Anogenital lesions in pediatric patients presented to Royal Medical Services (RMS) general dermatology clinics, who were five year old and younger. Read More

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http://dx.doi.org/10.5455/medarh.2020.74.28-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164741PMC
February 2020

Scientific evidence supporting recommendations on the use of the 9-valent HPV vaccine in a 2-dose vaccine schedule in Australia.

Commun Dis Intell (2018) 2020 Apr 15;44. Epub 2020 Apr 15.

Vaccinology and Immunology Research Trials Unit, Women's and Children's Hospital and Robinson Research Institute and Adelaide Medical School, University of Adelaide, North Adelaide, South Australia.

The Australian Technical Advisory Group on Immunisation (ATAGI) updated recommendations on the use of human papillomavirus (HPV) vaccines in the Australian Immunisation Handbook in 2018, regarding the use of the recently available 9-valent (9vHPV) vaccine, Gardasil 9, and a 2-dose schedule for young adolescents for HPV vaccines. This report provides an overview of the relevant scientific evidence that underpinned these updated recommendations. The 9vHPV vaccine includes 5 HPV types (HPV 31, 33, 45, 52 and 58) additional to the 4 that are also covered by the 4vHPV (Gardasil) vaccine (HPV 6,11,16,18). Read More

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http://dx.doi.org/10.33321/cdi.2020.44.33DOI Listing

Are genital examinations necessary for STI screening for female sex workers? An audit of decriminalized and regulated sex workers in Melbourne, Australia.

PLoS One 2020 16;15(4):e0231547. Epub 2020 Apr 16.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.

Background: The Victorian legislation prohibits sex workers from working when they have visible anogenital herpes or warts. The aim of this study was to determine the proportion of asymptomatic female sex workers (FSW) diagnosed with anogenital herpes or warts by genital examination.

Methods: We analysed all computerised medical records of consultations with FSW at the Melbourne Sexual Health Centre (MSHC) in 2018. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231547PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161967PMC

CO laser treatment for plantar warts in children: A case series.

Dermatol Ther 2020 May 27;33(3):e13414. Epub 2020 Apr 27.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Several types of human papillomaviruses induce warts. Warts are one of the most common infections in childhood with a reported prevalence of up to 20%. Warts are divided clinically into genital and nongenital forms. Read More

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http://dx.doi.org/10.1111/dth.13414DOI Listing

[Immunohistochemistry of p16 and p53 in vulvar cancer].

Medicina (B Aires) 2020 ;80(2):127-133

División Patología Ginecológica, Departamento de Patología, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.

Squamous cell carcinoma of the vulva may develop in association or independently of HPV infection. The relationship between pathogenesis, classification, immunohistochemical profile and prognosis has been studied in the literature with some discrepancies. The aim of this study was to observe the classical association of keratinizing carcinomas with the absence of HPV infection and warty and basaloid carcinomas with the presence of this virus. Read More

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Assessing Gammapapillomavirus infections of mucosal epithelia with two broad-spectrum PCR protocols.

BMC Infect Dis 2020 Apr 7;20(1):274. Epub 2020 Apr 7.

Grupo Virología Humana, Instituto de Biología Molecular y Celular de Rosario (CONICET), Suipacha 590, 2000, Rosario, Argentina.

Background: Human papillomaviruses (HPVs) have been divided into mucosal and cutaneous types according to their primary epithelial tissue tropism. However, recent studies showed the presence of several cutaneous types in mucosal lesions and healthy mucosa from different anatomical sites.

Methods: Here, the HPV prevalence and type-specific distribution were assessed in a variety of mucosal samples from 435 individuals using a combination of two established broad-spectrum primer systems: Gamma-PV PCR and CUT PCR. Read More

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http://dx.doi.org/10.1186/s12879-020-4893-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140492PMC

Awareness of oral and genital human papillomavirus (HPV) infection in young adolescents prior to gender-neutral vaccination.

BMJ Sex Reprod Health 2020 Apr 2. Epub 2020 Apr 2.

Human Sciences Research Centre, University of Derby, Derby, UK.

Introduction: Oral human papillomavirus (HPV) and oropharyngeal cancer prevalence are increasing, particularly in men. Raising greater awareness of male HPV disease is perceived as an important intervention strategy. This study investigated the effectiveness of HPV education on adolescents' perception of HPV disease and the impact of HPV vaccination on their sexual health. Read More

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http://dx.doi.org/10.1136/bmjsrh-2019-200410DOI Listing

Erythema nodosum induced by oral isotretinoin in a patient with condylomata acuminata.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, School of Medicine, University of Patras.

Erythema nodosum (EN) is a form of septal panniculitis, which is believed to represent a delayed hypersensitivity reaction activated by infectious agents, drugs, granulomatous and autoimmune diseases, pregnancy, and malignancies. There are only four reported cases of EN during oral isotretinoin therapy to our knowledge, all of them occurring in patients with severe acne. Since acne itself can trigger EN, the question as to whether there is indeed a causative relationship between isotretinoin and EN in the reported cases remains to be elucidated. Read More

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February 2020

Prevalence of Cervico-vaginal High-risk HPV Types and Other Sexually Transmitted Pathogens in Anogenital Warts Patients.

Anticancer Res 2020 Apr;40(4):2219-2223

1 Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Andreas Sygros" Hospital for Skin and Venereal Diseases, Athens, Greece.

Aim: To investigate the prevalence of cervico-vaginal co-infection with high-risk (HR) HPV types and other sexually transmitted pathogens (STPs) in women with anogenital warts (AGWs).

Patients And Methods: In this cross-sectional study, cervico-vaginal smears of women with AGWs were examined with real-time polymerase chain reaction for the presence of HR-HPV types and common STPs. Women with recent cervical HPV infection and general population were used for comparisons. Read More

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http://dx.doi.org/10.21873/anticanres.14183DOI Listing

[Correlation of human papillomavirus (HPV) and HPV vaccines with male reproductive health].

Zhonghua Nan Ke Xue 2019 Aug;25(8):749-753

Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

HPV is a very common virus worldwide spread by direct contact and involved in male reproductive health-related diseases such as infertility, condyloma acuminatum, and penile cancer. The development of HPV vaccines has contributed to the effective prevention of various subtypes of HPV and protection of males from HPV infection, especially the partners of HPV-positive females, the men who have sex with men, and those with a psychological fear of HPV infection. Therefore, HPV vaccines play an important role in the protection of males. Read More

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Influence of Gender and Undergraduate Course on the Knowledge about HPV and HPV Vaccine, and Vaccination Rate among Students of a Public University.

Rev Bras Ginecol Obstet 2020 Feb 30;42(2):96-105. Epub 2020 Mar 30.

Department of Obstetrics and Gynecology, Medical School, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Objective:  To evaluate the knowledge related to human papillomavirus (HPV) infection and the rate of HPV vaccination among undergraduate freshmen and senior students of medicine, pharmacy, speech therapy, nursing and physical education in a Brazilian university.

Methods:  A questionnaire concerning sociodemographic aspects, sexual background, and knowledge about HPV and its vaccine was filled out by 492 students. Three months later, a second questionnaire, concerning the new rate of vaccination, was applied to 233 students. Read More

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http://dx.doi.org/10.1055/s-0040-1701466DOI Listing
February 2020

HPV genotypic spectrum in Jilin province, China, where non-vaccine-covered HPV53 and 51 are prevalent, exhibits a bimodal age-specific pattern.

PLoS One 2020 24;15(3):e0230640. Epub 2020 Mar 24.

Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, China.

Background: Human papillomavirus (HPV), the most common sexually transmitted disease, is involved in a series of other diseases. The persistent infection of high-risk HPVs (HR-HPVs) is considered to be the causative agent of cervical cancer, and it is related to noncervical cancers. The present study aims to estimate the HPV prevalence and genotype distribution in Jilin province, China, to guide HPV-related cervical cancer screening and HPV vaccination. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230640PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313545PMC

Condylomata acuminata: A retrospective analysis on clinical characteristics and treatment options.

Heliyon 2020 Mar 11;6(3):e03547. Epub 2020 Mar 11.

Department of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.

Background: Anogenital HPV is the most frequent sexually transmitted disease (STD) worldwide. There is no obligation to officially register HPV infections in Germany and thus the epidemiology of condylomata acuminata (CA) is not well characterized.

Objectives: To provide a better understanding of the epidemiology of CA and outline the treatment options that are available to patients with this disease. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068618PMC

Increased risk of dementia in patients with genital warts: A nationwide cohort study in Taiwan.

J Dermatol 2020 May 18;47(5):503-511. Epub 2020 Mar 18.

Department of Psychiatry, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan.

Genital warts are a common sexually transmitted disease caused by human papillomavirus (HPV) infections. The prevalence of dementia is 4-8% in those aged 65 years or older in Taiwanese community studies, with a high social and economic burden for patients, family caregivers, the community and society. Previous studies have shown that viral infections such as herpes simplex and herpes zoster were associated with dementia. Read More

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http://dx.doi.org/10.1111/1346-8138.15277DOI Listing

Pan-urethral condylomata acuminata - A primary treatment recommendation based on our experience.

Urol Case Rep 2020 Jul 29;31:101149. Epub 2020 Feb 29.

Department of Urology, Austin Health, Heidelberg, VIC, Australia.

We present a case of a 28 year old man presenting with obstructive urinary tract symptoms and cystoscopic findings of pan-urethral, occlusive condylomata acuminata (urethral genital warts). We describe the in rooms administration process of 5-fluorouracil over an 8 week period with follow up cystoscopy results. Urine flow rates improved early in the treatment course from a maximum flow of 7ml/s to 19ml/s and a post void residual improvement from 311ml to 160ml. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056647PMC

Transcriptome analysis of HPV-induced warts and healthy skin in humans.

BMC Med Genomics 2020 03 9;13(1):35. Epub 2020 Mar 9.

Department of Internal Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Background: The human papillomaviruses (HPV) are a group of viruses that, depending on the strain, can cause cancer or the formation of benign growths known as warts. Scarce information exists with regard to the genetic nature of non-genital cutaneous warts induced by the human papillomavirus (HPV).

Methods: The main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. Read More

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http://dx.doi.org/10.1186/s12920-020-0700-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063766PMC

Aspects of Langerhans cells and TNF-α in the cutaneous immunity of anogenital warts.

An Bras Dermatol 2020 Mar - Apr;95(2):144-149. Epub 2020 Feb 12.

Pathology Laboratory, Santa Casa de Misericórdia de São Paulo, Vila Buarque, SP, Brazil.

Background: Anogenital warts are the leading sexually transmitted infection in patients seeking care at specialized clinics. They may display a vast array of forms, according to the interaction of the virus with the host's immunity. Cellular immunity is the epithelium's main form of defense against the virus, involving an active participation of the Langerhans cells and pro-inflammatory cytokines such as TNF-α. Read More

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http://dx.doi.org/10.1016/j.abd.2019.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175043PMC

The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease.

Front Immunol 2020 18;11:188. Epub 2020 Feb 18.

Department of Biology and Biotechnology "C. Darwin," Sapienza University, Rome, Italy.

Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040023PMC
February 2020

Prevention of Human Papillomavirus Infection. Beyond Cervical Cancer: A Brief Review.

Acta Med Port 2020 Mar 2;33(3):198-201. Epub 2020 Mar 2.

Department of Gynaecology. Hospital and University Centre of Coimbra. Coimbra. Department of Gynaecology. Faculty of Medicine. University of Coimbra. Coimbra. Portugal.

Introduction: Human papillomavirus is responsible for almost all cases of cervical cancer, an important portion of anogenital and oropharyngeal invasive and preinvasive lesions, as well as genital warts (condyloma acuminatum) and recurrent respiratory papillomatosis. Currently, three prophylactic vaccines against high-risk Human papillomavirus are commercialized in many countries worldwide.

Methods: To this non-systematic review the authors searched in MEDLINE/PubMed for systematic reviews, meta-analysis and randomized controlled trials, published in the last six years, using the terms "HPV", "non-cervical cancer" and "vaccine". Read More

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http://dx.doi.org/10.20344/amp.12259DOI Listing

Cure of condyloma acuminata covering the glans penis using aminolevulinic acid/photodynamic therapy.

Photodiagnosis Photodyn Ther 2020 Jun 26;30:101658. Epub 2020 Feb 26.

The First Affiliated Hospital of Zhengzhou University, China.

Condyloma acuminata are a type of verrucous hyperplasia in the genital and perianal areas caused by human papilloma virus (HPV) infection. Traditional treatment methods for condyloma acuminata, such as topical medications, carbon dioxide (CO) laser, cryotherapy, and surgical excision, can be effective at removing warts, however, they do not eliminate subclinical and latent HPV infection, resulting in a high recurrence rate and even leaving trauma and scars. We report a case of condyloma acuminata covering the glans penis, considering our patient had a singular, large lesion, thus, to reduce the risk of recurrence and minimize the trauma caused by treatment, we chose ALA/photodynamic therapy (ALA-PDT). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101658DOI Listing

Advanced application of holmium: YAG laser combined ALA-PDT for the treatment of refractory condylomata acuminata in anal canal.

Photodiagnosis Photodyn Ther 2020 Jun 25;30:101696. Epub 2020 Feb 25.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China. Electronic address:

Background: Anal canal condylomata acuminata is a disease caused by the human papilloma virus. Conventional cauterizing laser treatment cannot achieve a satisfactory result owing to a high recurrence rate, and the application of 5-aminolaevulinic acid-photodynamic therapy (ALA-PDT) also has limitations in the anal canal. Holmium yttrium aluminum garnet (Ho: YAG) laser with fiber is found to be effective at removing canal lesions, and may create suitable conditions for ALA-PDT. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101696DOI Listing

[Differential diagnosis of hemorrhoidal disease].

Authors:
A Herold

Hautarzt 2020 Apr;71(4):269-274

EDZ Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland.

Hemorrhoidal disease is one of the most common illnesses in industrialized nations. Up to 70% of adults suffer from the disease once in their lifetime. This underlines the necessity and importance of knowing about the differential diagnosis of hemorrhoids. Read More

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http://dx.doi.org/10.1007/s00105-020-04553-yDOI Listing