1,125 results match your criteria Genital Herpes in Pregnancy


[Diagnostic and therapeutic recommendations for sexually transmitted diseases: Genital herpes].

Ann Dermatol Venereol 2019 Jan 23;146(1):31-36. Epub 2018 Oct 23.

Marie-Victoire Senat, service de gynécologie-obstétrique, Paris-Sud-université Paris-Saclay, hôpital Bicêtre, AP-HP, Le Kremlin Bicêtre, France.

TREATMENT OF THE INITIAL INFECTION OR FIRST CLINICAL EPISODE OF GENITAL HERPES: An initial infection or first clinical episode of genital herpes is treated with oral aciclovir 200mg×5/d for 5 to 10 days depending on clinical status. The recommended dosage for valaciclovir is 1g×2/d and treatment duration is identical to that for aciclovir. TREATMENT OF HERPES RECURRING DURING PREGNANCY: There are no studies of the efficacy of antiviral therapy on the symptoms of genital recurring during pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183071
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http://dx.doi.org/10.1016/j.annder.2018.07.029DOI Listing
January 2019
13 Reads

Meta-analysis of prevalence of bovine herpes virus 1 in cattle in Mainland China.

Acta Trop 2018 Nov 25;187:37-43. Epub 2018 Jul 25.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China. Electronic address:

Bovine herpesvirus 1 (BHV-1), an important pathogen of cattle, can cause severe clinical syndromes including respiratory disease, genital disease, and late-term abortions, as well as neurological and systemic disease in cattle. For assessing the prevalence of BHV-1 infection in mainland China, a systematic review and meta-analysis was conducted. In this systematic review and meta-analysis, we searched English and Chinese literature databases for published paper regarding the prevalence of BHV-1 in cattle in China from inception to May 20, 2018. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.07.024DOI Listing
November 2018
8 Reads

Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study.

Am J Reprod Immunol 2018 Sep 14;80(3):e12995. Epub 2018 Jun 14.

Department of Epidemiology and Biostatistics, Texas A&M University, College Station, TX, USA.

Problem: Recently characterized interferon epsilon (IFNe) protects against sexually transmitted infections, including genital herpes simplex virus (HSV), in animal models. There are no reports of IFNe in genital tract secretions of pregnant women, and data on IFNe in non-pregnant women are limited. This pilot study is the first to measure concentrations of IFNe in vaginal and cervical secretions during pregnancy and compare values between healthy and genital HSV-infected women. Read More

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http://dx.doi.org/10.1111/aji.12995DOI Listing
September 2018
7 Reads

Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF).

Eur J Obstet Gynecol Reprod Biol 2018 May 9;224:93-101. Epub 2018 Mar 9.

Service de Gynécologie-Obstétrique, CHU Bordeaux, Bordeaux, France.

Objective: Identify measures to diagnose, prevent, and treat genital herpes infection during pregnancy and childbirth as well as neonatal herpes infection.

Materials And Methods: Bibliographic search from the Medline and Cochrane Library databases and review of international clinical practice guidelines.

Results: Genital herpes lesions are most often due to HSV-2 (LE2). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03012115183010
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http://dx.doi.org/10.1016/j.ejogrb.2018.03.011DOI Listing
May 2018
20 Reads

Dual infection in pregnancy: Disseminated Mycoplasma hominis and necrotizing herpes simplex 2 hepatitis.

Int J Infect Dis 2018 Jun 14;71:1-3. Epub 2018 Mar 14.

Department of Medicine, Division of Infectious Diseases, University of Alberta, 1-124C Clinical Sciences Building, 11304-83 Ave, Edmonton, Alberta, T6G 2G3, Canada. Electronic address:

Mycoplasma hominis is part of the genitourinary flora in sexually active people and can cause disseminated infection in immunocompromised patients. We describe a rare case of an immunocompetent pregnant woman with simultaneous necrotizing HSV hepatitis and disseminated M. hominis infection. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.03.006DOI Listing
June 2018
2 Reads

[The Spanish Society of Paediatric Infectious Diseases guidelines on the prevention, diagnosis and treatment of neonatal herpes simplex infections].

Authors:

An Pediatr (Barc) 2018 Jul 13;89(1):64.e1-64.e10. Epub 2018 Feb 13.

Neonatal herpes simplex virus infections are rare, but are associated with significant morbidity and mortality. Most newborns acquire herpes simplex virus infection in the peripartum period. For peripartum transmission to occur, women must be shedding the virus in their genital tracts symptomatically or asymptomatically around the time of delivery. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.01.004DOI Listing
July 2018
6 Reads

Herpes simplex virus type 2 IgG antibodies in sera of umbilical cord as a proxy for placental infection in asymptomatic pregnant women.

Am J Reprod Immunol 2018 04 10;79(4):e12824. Epub 2018 Feb 10.

Oncovirology Program, Instituto Nacional do Câncer (INCA), Rio de Janeiro, Brazil.

Problem: Herpes simplex virus type 2 (HSV-2) infection is one of the most prevalent diseases worldwide and is mainly sexually transmitted. When infecting pregnant women, HSV-2 is able to infect the placenta, can reach the fetus, and may affect the fetal development. We sought to determine the prevalence of HSV-2 infection and reactivation in asymptomatic pregnant women, the correlation between IgG in the maternal circulation and cord blood, and the correlation between circulating IgG, placental, and newborn infection (blood cord). Read More

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http://dx.doi.org/10.1111/aji.12824DOI Listing
April 2018
7 Reads

Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern?

Pediatr Infect Dis J 2018 Aug;37(8):806-813

From the Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Background: This article provides an update on the incidence of neonatal herpes, guideline adherence by health care professionals (HCP) and trends in genital herpes simplex virus (HSV) infection during pregnancy in the Netherlands.

Methods: Questionnaires were sent to all hospitals inquiring about numbers and characteristics of neonatal and maternal HSV infections, and guideline adherence between 2012 and 2015. Longitudinal trends were investigated from 1999 onward using survey data and Perinatal Registry of the Netherlands data (Perined). Read More

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http://dx.doi.org/10.1097/INF.0000000000001905DOI Listing
August 2018
4 Reads
2.723 Impact Factor

Invasive Obstetric Procedures and Cesarean Sections in Women With Known Herpes Simplex Virus Status During Pregnancy.

Open Forum Infect Dis 2017 6;4(4):ofx248. Epub 2017 Nov 6.

Department of Medicine, University of Washington, Seattle.

Background: Neonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (HSV) type 1 or 2 from the maternal genital tract at the time of vaginal delivery. Current guidelines recommend (1) cesarean delivery if maternal genital HSV lesions are present at the time of labor and (2) antiviral suppressive therapy for women with known genital herpes to decrease HSV shedding from the genital tract at the time of vaginal delivery. However, most neonatal infections occur in infants born to women without a history of genital HSV, making current prevention efforts ineffective for this group. Read More

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http://dx.doi.org/10.1093/ofid/ofx248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751035PMC
November 2017
13 Reads

Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068.

J Int AIDS Soc 2017 12;20(4)

Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, UK.

Introduction: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. Read More

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http://dx.doi.org/10.1002/jia2.25029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810346PMC
December 2017
14 Reads

[Endometrial dysfunction caused by chronic endometritis: сlinical and morphological aspects].

Arkh Patol 2017;79(6):22-29

Research Institute of Human Morphology, Moscow, Russia.

Aim: to determine the clinical and morphological aspects of endometrial dysfunction caused by chronic endometritis (CE).

Subjects And Methods: The study included 239 reproductive-aged patients: 93 were examined for abnormal uterine bleeding; 37 patients of them had a history of miscarriage and secondary infertility, 17 patients had primary infertility (Group 1). The remaining 105 patients with infertility were examined for future in vitro fertilization (Group 2). Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2017/6/dow
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http://dx.doi.org/10.17116/patol201779622-29DOI Listing
April 2018
17 Reads

Cervical HSV-2 infection causes cervical remodeling and increases risk for ascending infection and preterm birth.

PLoS One 2017 30;12(11):e0188645. Epub 2017 Nov 30.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America.

Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708831PMC
December 2017
9 Reads

[Herpes and pregnancy: Guidelines for clinical practice - method and organization].

Gynecol Obstet Fertil Senol 2017 12 13;45(12):640-641. Epub 2017 Nov 13.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

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https://linkinghub.elsevier.com/retrieve/pii/S24687189173024
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http://dx.doi.org/10.1016/j.gofs.2017.10.010DOI Listing
December 2017
1 Read

[Genital herpes and pregnancy: Epidemiology, clinical manifestations, prevention and screening. Guidelines for clinical practice from the French College of Gynecologists and Obstetrician (CNGOF)].

Authors:
O Picone

Gynecol Obstet Fertil Senol 2017 Dec 13;45(12):642-654. Epub 2017 Nov 13.

Department of Gynaecology and Obstetrics, hôpital Louis-Mourier, hôpitaux universitaires Paris Nord, 147, rue des Renouillets, 92700 Colombes, France. Electronic address:

Objectives: To analyze the consequences of genital herpes infections in pregnant women.

Methods: The PubMed database and the recommendations from the French and foreign obstetrical societies or colleges have been consulted.

Results: The symptomatology of herpes genital rash is often atypical (NP2) and not different during pregnancy (Professional consensus). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.002DOI Listing
December 2017
9 Reads

[Herpes and pregnancy: Guidelines for clinical practice - introduction].

Gynecol Obstet Fertil Senol 2017 12 11;45(12):639. Epub 2017 Nov 11.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

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https://linkinghub.elsevier.com/retrieve/pii/S24687189173024
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http://dx.doi.org/10.1016/j.gofs.2017.10.009DOI Listing
December 2017
1 Read

[Neonatal herpes: Epidemiology, clinical manifestations and management. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)].

Authors:
L Renesme

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):691-704. Epub 2017 Nov 11.

Unité de néonatalogie soins intensifs-pédiatrie de maternité, centre Aliénor d'Aquitaine, groupe hospitalier Pellegrin, centre hospitalier universitaire de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France. Electronic address:

Objectives: To describe the epidemiology of neonatal herpes and its risk factors, clinical and paraclinic manifestations, propose guidelines for a newborn at risk of neonatal herpes, describe treatment modalities, describe post-natal transmission and its prevention.

Methods: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines.

Results: Neonatal herpes is rare (about 20 cases per year in France) and mainly due to HSV 1 (level of evidence LE3). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.005DOI Listing
December 2017
3 Reads

[Management of pregnant women with recurrent herpes. Guidelines for clinical practice from the French College of Gynecologists, Obstetricians (CNGOF)].

Authors:
O Anselem

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):677-690. Epub 2017 Nov 11.

Maternité Port-Royal, université Paris Descartes, groupe hospitalier Cochin-Broca-Hôtel-Dieu, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; DHU risques et grossesse, PRES Sorbonne Paris Cité, 53, avenue de l'Observatoire, 75014 Paris, France. Electronic address:

Objective: To provide guidelines for the management of woman with genital herpes during pregnancy or labor and with known history of genital herpes.

Methods: MedLine and Cochrane Library databases search and review of the main foreign guidelines.

Results: Genital herpes ulceration during pregnancy in a woman with history of genital herpes correspond to a recurrence. Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.003DOI Listing
December 2017
7 Reads

[Genital herpes and pregnancy: Serological and molecular diagnostic tools. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)].

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):655-663. Epub 2017 Nov 11.

Laboratoire de virologie, hôpital Paul-Brousse, groupe hospitalier universitaire Paris-Sud, 12, rue Paul-Vaillant-Couturier, 94800 Villejuif, France. Electronic address:

Objectives: To describe serological and molecular tools available for genital and neonatal herpes, and their use in different clinical situations.

Methods: Bibliographic investigations from MedLine database and consultation of international clinical practice guidelines.

Results: Virological confirmation of genital herpes during pregnancy or neonatal herpes must rely on PCR (Professional consensus). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.004DOI Listing
December 2017
9 Reads

Prévention et prise en charge de l’infection herpétique au cours de la grossesse et de l’accouchement : recommandations pour la pratique clinique – texte des recommandations (texte court).

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):705-714. Epub 2017 Nov 11.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

Objective: Identify measures to diagnose, prevent and treat genital herpes infection during pregnancy and childbirth and neonatal infection.

Methods: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines.

Results: Genital herpes lesion is most often due to HSV2 (LE2). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.007DOI Listing
December 2017
16 Reads

[Management of pregnant women with first episode of genital herpes. Guidelines for clinical practice from the French college of gynecologists and obstetricians (CNGOF)].

Authors:
N Sananès

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):664-676. Epub 2017 Nov 11.

Service de gynécologie obstétrique, hôpitaux universitaires de Strasbourg, avenue Molière, BP 426, 67091 Strasbourg cedex, France; Unité Inserm UMR-S 1121 « Biomatériaux et Bioingénierie », 11, rue Humann, 67000 Strasbourg, France. Electronic address:

Objective: To provide guidelines for the management of first episode genital herpes during pregnancy and in the immediate postpartum period.

Methods: MedLine and Cochrane Library databases search and review of the main foreign guidelines.

Results: In case of first episode genital herpes during pregnancy, antiviral treatment with acyclovir (200mg 5 times daily) or valacyclovir (1000mg twice daily) for 5 to 10 days is recommended (grade C). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.006DOI Listing
December 2017
10 Reads

Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis.

Eur J Obstet Gynecol Reprod Biol 2017 12 23;219:133. Epub 2017 Oct 23.

City Hospitals Sunderland NHS Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1016/j.ejogrb.2017.10.014DOI Listing
December 2017
5 Reads

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes: A Case-control Study.

Chin Med J (Engl) 2017 Oct;130(20):2416-2422

Department of Microbiology and Immunology, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Background: Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. Read More

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http://dx.doi.org/10.4103/0366-6999.216396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684638PMC
October 2017
22 Reads

Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model.

PLoS One 2017 5;12(10):e0185946. Epub 2017 Oct 5.

Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.

Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628903PMC
October 2017
43 Reads

2017 European guidelines for the management of genital herpes.

Int J STD AIDS 2017 12 24;28(14):1366-1379. Epub 2017 Aug 24.

1 Department of Genitourinary Medicine, Southampton, UK.

Genital herpes is one of the commonest sexually transmitted infections worldwide. Using the best available evidence, this guideline recommends strategies for diagnosis, management, and follow-up of the condition as well as for minimising transmission. Early recognition and initiation of therapy is key and may reduce the duration of illness or avoid hospitalisation with complications, including urinary retention, meningism, or severe systemic illness. Read More

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http://dx.doi.org/10.1177/0956462417727194DOI Listing
December 2017
110 Reads

Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti.

BMC Infect Dis 2017 08 18;17(1):577. Epub 2017 Aug 18.

Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, 30329, USA.

Background: Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population. Read More

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http://dx.doi.org/10.1186/s12879-017-2674-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563013PMC
August 2017
17 Reads

Rubella, herpes simplex virus type 2 and preeclampsia.

Virol J 2017 07 26;14(1):142. Epub 2017 Jul 26.

Faculty of Medicine, University of Khartoum, P. O. Box 102, Khartoum, Sudan.

Background: Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.

Objective: The aim of the present study was to investigate the association between maternal seropositivity of rubella, Herpes simplex virus type 2 (HSV-2) and preeclampsia. Read More

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http://dx.doi.org/10.1186/s12985-017-0813-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530498PMC
July 2017
6 Reads

No. 208-Guidelines for the Management of Herpes Simplex Virus in Pregnancy.

J Obstet Gynaecol Can 2017 Aug;39(8):e199-e205

Montréal, QC.

Objective: To provide recommendations for the management of genital herpes infection in women who want to get pregnant or are pregnant and for the management of genital herpes in pregnancy and strategies to prevent transmission to the infant.

Outcomes: More effective management of complications of genital herpes in pregnancy and prevention of transmission of genital herpes from mother to infant.

Evidence: Medline was searched for articles published in French or English related to genital herpes and pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163173045
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http://dx.doi.org/10.1016/j.jogc.2017.04.016DOI Listing
August 2017
21 Reads

N 208-Directive clinique sur la prise en charge du virus de l’herpès simplex pendant la grossesse.

J Obstet Gynaecol Can 2017 Aug;39(8):e192-e198

Montréal (Québec).

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http://dx.doi.org/10.1016/j.jogc.2017.04.017DOI Listing
August 2017
15 Reads

Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control.

BMC Infect Dis 2017 07 6;17(1):471. Epub 2017 Jul 6.

Robert Koch Institute (RKI), Berlin, Germany.

Background: Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are scarce. A previous study found higher HSV1/2 seroprevalences in women in East Germany than in women in West Germany. Read More

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http://dx.doi.org/10.1186/s12879-017-2527-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500947PMC
July 2017
22 Reads

Diagnosis and treatment of herpes simplex 1 virus infection in pregnancy.

Obstet Med 2017 Jun 1;10(2):58-60. Epub 2017 Feb 1.

Department of Obstetrics and Gynaecology, Royal Gwent Hospital, Newport, UK.

A nulliparous woman presented at 21 weeks' gestation with a 72-h history of a rash on her left arm. Initially isolated to the forearm, it had quickly spread, becoming multiple itchy fluid-filled blisters. Blood tests showed mild neutrophilia and raised CRP. Read More

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http://dx.doi.org/10.1177/1753495X16689434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480650PMC
June 2017
5 Reads

Prevalence and risk factors of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in Papua New Guinea: a cross-sectional survey.

Sex Health 2016 10;13(5):420-427

Public Health Interventions Research Group, Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

Background Papua New Guinea (PNG) is estimated to have among the highest prevalences of HIV and sexually transmissible infections (STIs) of any Asia-Pacific country, and one of the highest burdens of maternal syphilis globally. The prevalence of curable STIs, such as Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV), among pregnant women in PNG is relatively unknown.

Methods: A cross-sectional bio-behavioural survey to investigate the epidemiology of CT, NG, TV and other STIs among pregnant women in three provinces of PNG was undertaken. Read More

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http://dx.doi.org/10.1071/SH15227DOI Listing
October 2016
27 Reads

Does maternal HSV-2 coinfection increase mother-to-child transmission of HIV? A systematic review.

Sex Transm Infect 2017 12 9;93(8):535-542. Epub 2017 Jun 9.

Division of Infectious Diseases, St. Michael's Hospital, Toronto, Canada.

Background: Reducing HIV mother-to-child transmission (MTCT) is critical to ending the HIV pandemic. Reports suggest that herpes simplex virus-2 (HSV-2), a common coinfection in HIV-infected individuals, is associated with increased MTCT, but results have been conflicting. We conducted a systematic review of observational studies to quantify the magnitude of this relationship (PROSPERO no. Read More

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http://dx.doi.org/10.1136/sextrans-2016-052921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739864PMC
December 2017
15 Reads

Prevalence of herpes simplex virus types 1 and 2 at maternal and fetal sides of the placenta in asymptomatic pregnant women.

Am J Reprod Immunol 2017 07 25;78(1). Epub 2017 Apr 25.

Oncovirology Program, Instituto Nacional do Câncer (INCA), Rio de Janeiro, Rio de Janeiro, Brazil.

Problem: Herpes simplex virus 1 (HSV-1) commonly causes orolabial infection, but can also infect the genital mucosa. In contrast, HSV-2 is usually genital. Genital herpes can transmit the virus vertically to the fetus during pregnancy. Read More

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http://dx.doi.org/10.1111/aji.12689DOI Listing
July 2017
17 Reads

Skin diseases of the vulva: Infectious diseases.

J Obstet Gynaecol 2017 Oct 11;37(7):840-848. Epub 2017 Apr 11.

a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.

A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2017.1
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http://dx.doi.org/10.1080/01443615.2017.1306696DOI Listing
October 2017
33 Reads

Pregnancy Outcomes in Association with STDs including genital HSV-2 shedding in a South African Cohort Study.

Sex Transm Infect 2017 11 10;93(7):460-466. Epub 2017 Apr 10.

Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Objectives: Genital herpes simplex virus-2 (HSV-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes.

Methods: In his retrospective observational study, we included a subgroup of pregnant women who were enrolled in a randomized control behavioural intervention study that was conducted in South Africa in 2008-2010. In pregnancy, women had a HIV rapid test done and a genital swab taken to test for curable STIs and HSV-2 DNA. Read More

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http://dx.doi.org/10.1136/sextrans-2017-053113DOI Listing
November 2017
10 Reads

Effect of suppressive acyclovir administered to HSV-2 positive mothers from week 28 to 36 weeks of pregnancy on adverse obstetric outcomes: a double-blind randomised placebo-controlled trial.

Reprod Health 2017 Mar 3;14(1):31. Epub 2017 Mar 3.

Department of Obstetrics and Gynaecology, School of Medicine, Makerere University College of Health Sciences, P. O. Box 7072, Kampala, Uganda.

Background: Acyclovir (ACV) given to HSV-2 positive women after 36 weeks reduces adverse outcomes but its benefit at lower gestation was undocumented. We determined the effect of oral acyclovir administered from 28 to 36 weeks on premature rupture of membranes (PROM) primarily and preterm delivery risk.

Methods: This was a randomized, double-blind placebo-controlled trial among 200 HSV-2 positive pregnant women at 28 weeks of gestation at Mulago Hospital, Uganda. Read More

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http://dx.doi.org/10.1186/s12978-017-0292-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335854PMC
March 2017
11 Reads

Why neonatal herpes matters.

Lancet Glob Health 2017 03 31;5(3):e234-e235. Epub 2017 Jan 31.

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(17)30047-5DOI Listing
March 2017
2 Reads

First estimates of the global and regional incidence of neonatal herpes infection.

Lancet Glob Health 2017 03 31;5(3):e300-e309. Epub 2017 Jan 31.

Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Background: Neonatal herpes is a rare but potentially devastating condition with an estimated 60% fatality rate without treatment. Transmission usually occurs during delivery from mothers with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) genital infection. However, the global burden has never been quantified to our knowledge. Read More

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http://dx.doi.org/10.1016/S2214-109X(16)30362-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837040PMC
March 2017
3 Reads

Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement.

JAMA 2016 12;316(23):2525-2530

University of Hawaii, Manoa.

Importance: Genital herpes is a prevalent sexually transmitted infection in the United States, occurring in almost 1 in 6 persons aged 14 to 49 years. Infection is caused by 2 subtypes of the herpes simplex virus (HSV), HSV-1 and HSV-2. Antiviral medications may provide symptomatic relief from outbreaks but do not cure HSV infection. Read More

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http://dx.doi.org/10.1001/jama.2016.16776DOI Listing
December 2016
21 Reads

School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents.

Cochrane Database Syst Rev 2016 11 8;11:CD006417. Epub 2016 Nov 8.

Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, York, UK, YO10 5DD.

Background: School-based sexual and reproductive health programmes are widely accepted as an approach to reducing high-risk sexual behaviour among adolescents. Many studies and systematic reviews have concentrated on measuring effects on knowledge or self-reported behaviour rather than biological outcomes, such as pregnancy or prevalence of sexually transmitted infections (STIs).

Objectives: To evaluate the effects of school-based sexual and reproductive health programmes on sexually transmitted infections (such as HIV, herpes simplex virus, and syphilis), and pregnancy among adolescents. Read More

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http://dx.doi.org/10.1002/14651858.CD006417.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461872PMC
November 2016
54 Reads

Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study.

J Infect Dev Ctries 2016 Oct 31;10(10):1108-1115. Epub 2016 Oct 31.

Makerere University College of Health Sciences, Kampala, Uganda.

Introduction: Herpes simplex virus type 2 (HSV-2) acquired during pregnancy is associated with adverse outcomes such as perinatal HSV-2 transmission. HSV-2 seroconversion occurs within four weeks of HSV-2 acquisition. There was neither documented incidence nor risk factors for HSV-2 seroconversion during pregnancy in Uganda. Read More

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https://jidc.org/index.php/journal/article/view/27801374
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http://dx.doi.org/10.3855/jidc.6874DOI Listing
October 2016
16 Reads

[Genital herpes].

Ann Dermatol Venereol 2016 Nov 19;143(11):729-733. Epub 2016 Oct 19.

Service de dermatologie, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.

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http://dx.doi.org/10.1016/j.annder.2016.09.009DOI Listing
November 2016
9 Reads

Association of Depressed Mood With Herpes Simplex Virus-2 Immunoglobulin-G Levels in Pregnancy.

Psychosom Med 2016 10;78(8):966-972

From the College of Nursing (Hsu, Beckie, Munro, Groer), University of South Florida, Tampa, Florida; School of Medicine, Stanley Virology Laboratory (Yolken), Johns Hopkins University, Baltimore, Maryland; and School of Medicine, University of Maryland (Postolache), Baltimore, Maryland, and the Rocky Mountain MIRECC, Denver, Colorado.

Objective: Depressed mood is common in pregnancy, is associated with stress, and could result in immune suppression that may lead to latent herpes viral reactivation. This study investigated whether depressed mood is associated with higher herpes viral IgG levels in pregnant women.

Methods: Complete cross-sectional data from 247 pregnant women were available for this substudy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067962PMC
http://dx.doi.org/10.1097/PSY.0000000000000374DOI Listing
October 2016
6 Reads

A randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy.

J Int AIDS Soc 2016;19(1):20990. Epub 2016 Sep 21.

Office of the Global AIDS Coordinator and Health Diplomacy, US Department of State, Washington, DC, USA.

Introduction: Vaginal tenofovir (TFV) 1% gel may reduce incident HIV-1 and herpes simplex virus 2 infection. Pregnancy may increase risk of HIV acquisition, and incident HIV in pregnancy potentiates perinatal HIV transmission. Our objective was to investigate the safety and pharmacokinetics of seven days of TFV 1% vaginal gel in term and near-term pregnancy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034095PMC
http://dx.doi.org/10.7448/IAS.19.1.20990DOI Listing
September 2016
14 Reads

HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells.

Am J Reprod Immunol 2016 11 10;76(5):348-357. Epub 2016 Sep 10.

Division of Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.

Problem: Zika virus (ZIKV) has gained public concern for its association with microcephaly in infants born to ZIKV-infected mothers. To reach the fetus the virus must overcome the defense mechanisms provided by trophoblast cells. Additionally, in the first trimester, the integrity of the placenta is critical for fetal protection as damage to differentiating trophoblast can affect placental formation and function. Read More

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http://dx.doi.org/10.1111/aji.12578DOI Listing
November 2016
63 Reads

Herpes simplex virus type 1 and type 2 in the Netherlands: seroprevalence, risk factors and changes during a 12-year period.

BMC Infect Dis 2016 08 2;16:364. Epub 2016 Aug 2.

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Background: Genital herpes results in considerable morbidity, including risk of neonatal herpes, and is increasingly being caused by Herpes Simplex Virus (HSV) type 1. Possibly children are less often HSV-1 infected, leaving them susceptible until sexual debut. We assessed changes in the Dutch HSV-1 and HSV-2 seroprevalence over time and determinants associated with HSV seropositivity. Read More

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http://dx.doi.org/10.1186/s12879-016-1707-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971663PMC
August 2016
21 Reads

Collaboration with a midwife in the care of a pregnant patient with recurrent genital herpes simplex virus.

Can Fam Physician 2016 Jul;62(7):562-4

Assistant Professor of Family Medicine at Western University and is a practising family physician at the Byron Family Medical Centre.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955083PMC
July 2016
3 Reads

Genital Herpes: A Review.

Authors:
Mary Jo Groves

Am Fam Physician 2016 Jun;93(11):928-34

Wright State University Boonshoft School of Medicine, Dayton, OH, USA.

Genital herpes is a common sexually transmitted disease, affecting more than 400 million persons worldwide. It is caused by herpes simplex virus (HSV) and characterized by lifelong infection and periodic reactivation. A visible outbreak consists of single or clustered vesicles on the genitalia, perineum, buttocks, upper thighs, or perianal areas that ulcerate before resolving. Read More

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June 2016
5 Reads

Skin infections in pregnancy.

Clin Dermatol 2016 May-Jun;34(3):368-77. Epub 2016 Feb 9.

Allergy Unit, Department of Dermatology, University Hospital and University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.

A wide array of infectious diseases can occur in pregnancy. Their acquisition, clinical presentation, and course during gestation may be altered due to an impairment of the maternal cellular immunity. Some infectious diseases can lead to serious consequences for the mother or the offspring, including congenital malformations. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.02.009DOI Listing
May 2017
3 Reads