1,147 results match your criteria Genital Herpes in Pregnancy


Management of Genital Herpes in Pregnancy: ACOG Practice Bulletinacog Practice Bulletin, Number 220.

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Obstet Gynecol 2020 05;135(5):e193-e202

Genital herpes simplex virus (HSV) infection during pregnancy poses a risk to the developing fetus and newborn. Genital herpes is common in the United States. Among 14- to 49-year-old females, the prevalence of HSV-2 infection is 15. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003840DOI Listing

Management of Genital Herpes in Pregnancy: ACOG Practice Bulletin Summary, Number 220.

Authors:

Obstet Gynecol 2020 May;135(5):1236-1238

Genital herpes simplex virus (HSV) infection during pregnancy poses a risk to the developing fetus and newborn. Genital herpes is common in the United States. Among 14- to 49-year-old females, the prevalence of HSV-2 infection is 15. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003841DOI Listing

Genital herpes and pregnancy: Evaluating practices and knowledge of French health care providers.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 26;249:84-91. Epub 2020 Feb 26.

Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Colombes, France; Université de Paris, Paris, France; Inserm IAME-U1137, Paris, France; Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), France. Electronic address:

Background: Genital herpes during pregnancy is a frequent occurrence, whereas infection of newborns is rare but likely severe. In the absence of specific national guidelines from the CNGOF (French National College of Gynaecologists and Obstetricians) in France until December 2017, we supposed that knowledge of health care providers on the topic was not up to date.

Objective: To assess health care provider knowledge of genital herpes and management practices during pregnancy, before the publication of national recommendations edited by the CNGOF. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.02.039DOI Listing

[Genital herpes simplex virus infection in pregnancy].

Ugeskr Laeger 2020 Jan;182(5)

In this review, we discuss genital herpes - a common sexually transmitted infection, which can be transmitted to the baby during birth. Neonatal herpes is a rare but serious infection. In 2019, the Danish Society of Obstetrics and Gynecology revised the guideline for management of genital herpes in pregnancy. Read More

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January 2020

Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age.

PLoS One 2020 8;15(1):e0224359. Epub 2020 Jan 8.

CONRAD, Arlington, VA, United States of America.

Sexually transmitted infections (STIs) and vaginal dysbiosis (disturbed resident microbiota presenting with abnormal Nugent score or candidiasis) have been associated with mucosal inflammation and risk of HIV-1 infection, cancer and poor reproductive outcomes. To date, the temporal relationships between aberrant cervical innate immunity and the clinical onset of microbial disturbance have not been studied in a large population of reproductive age women. We examined data from a longitudinal cohort of 934 Ugandan and Zimbabwean women contributing 3,274 HIV-negative visits who had complete laboratory, clinical and demographic data. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224359PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948729PMC

Genital zoster in near term pregnancy: Case report and need of management guidelines.

J Gynecol Obstet Hum Reprod 2020 Feb 15;49(2):101675. Epub 2019 Dec 15.

Université de Paris, APHP, Hôpital Cochin, Service de Virologie, France. Electronic address:

Genital herpes simplex infection close to delivery may be transmitted to the newborn. Guidelines for genital herpes during pregnancy have been elaborated to reduce the risks of neonatal herpes. Genital herpes zoster due to reactivation of varicella zoster virus (VZV) from sacral ganglia is an under recognized cause of genital lesions. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.101675DOI Listing
February 2020

Herpes Simplex Virus Type 2 Seroprevalence in Pregnant Women in Urmia, Northwest of Iran, during 2014-2015

Iran Biomed J 2020 03 1;24(2):136-9. Epub 2019 Nov 1.

Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Urmia University of Medical Sciences, Urmia, Iran.

Background: Herpes simplex virus type 2 (HSV-2) seroprevalence has been shown to be a potential sign of infection in pregnant women, and it could be applied to check HSV-2 transmission. This study evaluated the anti-HSV-2 IgG prevalence in pregnant women who were referred to health centers in Urmia, Northwest of Iran, during 2014-2015.

Methods: Serum samples were collected from 86 pregnant women and tested for Anti-HSV-2-specific IgG using a commercial enzyme-linked immunosorbent assays kit. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984710PMC
March 2020
1 Read

Successful sofosbuvir lead-in monotherapy for the treatment of hepatitis C virus (HCV) infection in a pregnant woman living with HIV.

BMJ Case Rep 2019 Oct 23;12(10). Epub 2019 Oct 23.

Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA

A 30-year-old woman living with HIV was diagnosed with genotype 2b hepatitis C virus (HCV) infection during the second trimester of her pregnancy. She had achieved virologic suppression on an HIV protease inhibitor-based regimen and had recurrent genital herpes simplex virus infection managed with antivirals. Given the risk of perinatal transmission of HCV and to avoid performing a caesarean section, after multidisciplinary consultations and consideration of the limited data on safety on HCV direct-acting antivirals (DAAs) in pregnancy, she consented to and was successfully treated with a 6-week lead-in course of sofosbuvir (SOF) alone followed by a 6-week course of SOF and velpatasvir postpartum. Read More

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http://dx.doi.org/10.1136/bcr-2019-230529DOI Listing
October 2019
1 Read

Menstrual cups and cash transfer to reduce sexual and reproductive harm and school dropout in adolescent schoolgirls: study protocol of a cluster-randomised controlled trial in western Kenya.

BMC Public Health 2019 Oct 21;19(1):1317. Epub 2019 Oct 21.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.

Background: Adolescent girls in sub-Saharan Africa are disproportionally vulnerable to sexual and reproductive health (SRH) harms. In western Kenya, where unprotected transactional sex is common, young females face higher rates of school dropout, often due to pregnancy, and sexually transmitted infections (STIs), including HIV. Staying in school has shown to protect girls against early marriage, teen pregnancy, and HIV infection. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-7594-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805471PMC
October 2019
2 Reads
2.264 Impact Factor

Data-driven queries between medications and spontaneous preterm birth among 2.5 million pregnancies.

Birth Defects Res 2019 10 21;111(16):1145-1153. Epub 2019 Aug 21.

Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

Background: Our goal was to develop an approach that can systematically identify potential associations between medication prescribed in pregnancy and spontaneous preterm birth (sPTB) by mining large administrative "claims" databases containing hundreds of medications. One such association that we illustrate emerged with antiviral medications used for herpes treatment.

Methods: IBM MarketScan® databases (2007-2016) were used. Read More

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http://dx.doi.org/10.1002/bdr2.1580DOI Listing
October 2019
3 Reads

Lichen Sclerosus on the Sites of Striae Distensae and a Surgical Scar in a Patient with Coexistent Morphea.

Acta Dermatovenerol Croat 2019 Mar;27(1):44-46

Sevkiye Copur, MD, Department of Dermatology & Venereology, Istanbul University, Istanbul Medical Faculty , Millet Street (Caddesi), 34093 Capa , Istanbul, Turkey;

Lichen sclerosus (LS), also known as lichen sclerosus et atrophicus, is a chronic inflammatory mucocutaneous disease affecting the genital and/or extragenital areas. Although LS usually occurs alone, its coexistence in morphea patients has been reported in 5.7% and 38. Read More

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March 2019
15 Reads

Maintaining Breastfeeding During Severe Infant and Maternal HSV-1 Infection: A Case Report.

J Hum Lact 2019 Nov 6;35(4):737-741. Epub 2019 Mar 6.

Professor of Perinatal Nursing & Helen M. Shearer Professor of Nutrition, University of Pennsylvania School of Nursing, Philadelphia, PA, USA.

Introduction: Childbearing women with primary or secondary Herpes Simplex Virus type 1 infection are at risk of transmitting neonatal herpes infection to their infants; a medical emergency that is associated with high mortality and morbidity. Neonatal herpes infection has been commonly associated with Herpes Simplex Virus type 2, or genital herpes, but can be caused by either subtype and the presentations are indistinguishable. This case describes the course of diagnosis, treatment, and recovery for a mother and infant during a severe maternal and neonatal herpes infection, and how lactation was maintained and breastfeeding re-established. Read More

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http://dx.doi.org/10.1177/0890334419830994DOI Listing
November 2019
1 Read

Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey.

Z Geburtshilfe Neonatol 2020 Feb 4;224(1):22-25. Epub 2019 Mar 4.

Obstetrics and Gynecology, Ankara, Zekai Tahir Burak Health Practice Research Center, University of Health Sciences, Turkey.

Objective: The present study aimed to determine herpes simplex virus (HSV) infection during pregnancy, serologic status of symptomatic patients, and the frequency of PCR and culture positivity and neonatal disease in an obstetric population.

Materials And Methods: Sera of 1,690 women with genital lesions were tested for HSV IgM and/or HSV IgG between 2008 and 2017. All the patients were evaluated by PCR and viral culture to demonstrate genital herpes infection. Read More

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http://dx.doi.org/10.1055/a-0842-6941DOI Listing
February 2020
11 Reads

Co-infection of Herpes Simplex Virus Type 2 and HIV Infections among Pregnant Women in Ibadan, Nigeria.

J Glob Infect Dis 2019 Jan-Mar;11(1):19-24

Department of Medical Microbiology and Parasitology, University College Hospital, Ibadan, Oyo State, Nigeria.

Introduction: Genital infection with herpes simplex virus type 2 (HSV-2) facilitates the acquisition of HIV, both mutually reinforcing infection. Lifelong latent HSV-2 infection raises concerns among women of reproductive age, considering the risk of neonatal transmission. In Nigeria, screening for HSV-2 and co-infection with HIV in antenatal clinics is not routine. Read More

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http://dx.doi.org/10.4103/jgid.jgid_56_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380096PMC
March 2019
8 Reads

Prevalence of sexually transmitted infections (HIV, hepatitis B virus, herpes simplex virus type 2, and syphilis) in pregnant women in Ethiopia: Trends over 10 years (2005-2014).

Int J Infect Dis 2019 Feb 22;79:50-57. Epub 2018 Nov 22.

HIV/AIDS and Tuberculosis Research Directorate, Ethiopian Public Health Institute (EPHI), Addis Ababa, Ethiopia. Electronic address:

Objectives: This study was performed to determine the trends in seroprevalence of four major sexually transmitted infections (STIs) (HIV, hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), and syphilis) over a 10-year period (2005-2014) in pregnant women in Ethiopia.

Methods: Pregnant women (15-49 years old) who were enrolled in the antenatal care-based national HIV surveillance were included. Serological tests for HIV, HBV, HSV-2, and syphilis were done on serum/plasma samples. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.11.009DOI Listing
February 2019
12 Reads

[Diagnostic and therapeutic recommendations for sexually transmitted diseases: Genital herpes].

Ann Dermatol Venereol 2019 Jan 23;146(1):31-36. Epub 2018 Oct 23.

Marie-Victoire Senat, service de gynécologie-obstétrique, Paris-Sud-université Paris-Saclay, hôpital Bicêtre, AP-HP, Le Kremlin Bicêtre, France.

TREATMENT OF THE INITIAL INFECTION OR FIRST CLINICAL EPISODE OF GENITAL HERPES: An initial infection or first clinical episode of genital herpes is treated with oral aciclovir 200mg×5/d for 5 to 10 days depending on clinical status. The recommended dosage for valaciclovir is 1g×2/d and treatment duration is identical to that for aciclovir. TREATMENT OF HERPES RECURRING DURING PREGNANCY: There are no studies of the efficacy of antiviral therapy on the symptoms of genital recurring during pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183071
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http://dx.doi.org/10.1016/j.annder.2018.07.029DOI Listing
January 2019
42 Reads

ACOG Committee Opinion No. 754: The Utility of and Indications for Routine Pelvic Examination.

Authors:

Obstet Gynecol 2018 10;132(4):e174-e180

The pelvic examination has long been considered a fundamental component of the well-woman visit, and many women and gynecologic care providers view this visit as an opportunity to discuss sexual and reproductive health issues. Traditionally, a pelvic examination is performed for asymptomatic women as a screening tool for gynecologic cancer, infection, and asymptomatic pelvic inflammatory disease; some obstetrician-gynecologists and patients consider it important in detecting subclinical disease, despite evidence to the contrary. Given changes in screening recommendations and the ability to screen for sexually transmitted infections using less-invasive methods, reevaluation of the role of the pelvic examination for asymptomatic, nonpregnant women is warranted. Read More

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http://dx.doi.org/10.1097/AOG.0000000000002895DOI Listing
October 2018
7 Reads

Should Caesarian Section Be Offered to Women With Recurrent Genital Herpes Simplex Lesions After >4 Hours of Ruptured Membranes?

J Obstet Gynaecol Can 2018 08;40(8):1054-1056

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB.

Background: Neonatal herpes simplex virus (HSV) infection and its implications have been well defined. Several methods are recommended to mitigate the risk of maternal transmission of HSV to the neonate, including CS, suppressive antiviral therapy for the mother, and prophylaxis for the infant. The utility of CS in women who present with a duration of rupture of membranes greater than 4 hours remains a question. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163173089
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http://dx.doi.org/10.1016/j.jogc.2018.01.001DOI Listing
August 2018
32 Reads

Meta-analysis of prevalence of bovine herpes virus 1 in cattle in Mainland China.

Acta Trop 2018 Nov 25;187:37-43. Epub 2018 Jul 25.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China. Electronic address:

Bovine herpesvirus 1 (BHV-1), an important pathogen of cattle, can cause severe clinical syndromes including respiratory disease, genital disease, and late-term abortions, as well as neurological and systemic disease in cattle. For assessing the prevalence of BHV-1 infection in mainland China, a systematic review and meta-analysis was conducted. In this systematic review and meta-analysis, we searched English and Chinese literature databases for published paper regarding the prevalence of BHV-1 in cattle in China from inception to May 20, 2018. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.07.024DOI Listing
November 2018
18 Reads

Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study.

Am J Reprod Immunol 2018 09 14;80(3):e12995. Epub 2018 Jun 14.

Department of Epidemiology and Biostatistics, Texas A&M University, College Station, TX, USA.

Problem: Recently characterized interferon epsilon (IFNe) protects against sexually transmitted infections, including genital herpes simplex virus (HSV), in animal models. There are no reports of IFNe in genital tract secretions of pregnant women, and data on IFNe in non-pregnant women are limited. This pilot study is the first to measure concentrations of IFNe in vaginal and cervical secretions during pregnancy and compare values between healthy and genital HSV-infected women. Read More

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http://dx.doi.org/10.1111/aji.12995DOI Listing
September 2018
13 Reads

Seroprevalence of Herpes Simplex Virus Types 1 and 2 Among Pregnant Women and Sexually Active, Nonpregnant Women in the United States.

Clin Infect Dis 2018 10;67(10):1535-1542

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Neonatal herpes is a rare, devastating consequence of herpes simplex virus type 1 (HSV-1) or 2 (HSV-2) infection during pregnancy. The risk of neonatal infection is higher among pregnant women seronegative for HSV-1 or HSV-2 who acquire their first HSV infection near delivery.

Methods: We estimated HSV-1 and HSV-2 seroprevalence among pregnant women aged 20-39 years in 1999-2014, assessed HSV seroprevalence changes between 1999-2006 and 2007-2014, and compared HSV seroprevalence between pregnant women and sexually active, nonpregnant women aged 20-39 years in 2007-2014 using National Health and Nutrition Examination Survey data. Read More

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http://dx.doi.org/10.1093/cid/ciy318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369524PMC
October 2018
11 Reads

Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF).

Eur J Obstet Gynecol Reprod Biol 2018 May 9;224:93-101. Epub 2018 Mar 9.

Service de Gynécologie-Obstétrique, CHU Bordeaux, Bordeaux, France.

Objective: Identify measures to diagnose, prevent, and treat genital herpes infection during pregnancy and childbirth as well as neonatal herpes infection.

Materials And Methods: Bibliographic search from the Medline and Cochrane Library databases and review of international clinical practice guidelines.

Results: Genital herpes lesions are most often due to HSV-2 (LE2). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03012115183010
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http://dx.doi.org/10.1016/j.ejogrb.2018.03.011DOI Listing
May 2018
31 Reads

Dual infection in pregnancy: Disseminated Mycoplasma hominis and necrotizing herpes simplex 2 hepatitis.

Int J Infect Dis 2018 Jun 14;71:1-3. Epub 2018 Mar 14.

Department of Medicine, Division of Infectious Diseases, University of Alberta, 1-124C Clinical Sciences Building, 11304-83 Ave, Edmonton, Alberta, T6G 2G3, Canada. Electronic address:

Mycoplasma hominis is part of the genitourinary flora in sexually active people and can cause disseminated infection in immunocompromised patients. We describe a rare case of an immunocompetent pregnant woman with simultaneous necrotizing HSV hepatitis and disseminated M. hominis infection. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.03.006DOI Listing
June 2018
9 Reads

Neonatal herpes simplex virus infections.

Semin Perinatol 2018 04 12;42(3):168-175. Epub 2018 Mar 12.

Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue South, CHB 303, Birmingham, AL 35233. Electronic address:

Neonatal herpes simplex virus (HSV) is an uncommon but devastating infection in the newborn, associated with significant morbidity and mortality. The use of PCR for identification of infected infants and acyclovir for treatment has significantly improved the prognosis for affected infants. The subsequent use of suppressive therapy with oral acyclovir following completion of parenteral treatment of acute disease has further enhanced the long-term prognosis for these infants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005183001
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http://dx.doi.org/10.1053/j.semperi.2018.02.004DOI Listing
April 2018
10 Reads

Maternal cytomegalovirus sero-positivity and autism symptoms in children.

Am J Reprod Immunol 2018 05 9;79(5):e12840. Epub 2018 Mar 9.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.

Problem: Autism spectrum disorder (ASD) is one of the most commonly diagnosed neurodevelopmental disorders in the United States. While ASD can be significantly influenced by genetics, prenatal exposure to maternal infections has also been implicated in conferring risk. Despite this, the effects of several important maternal pathogens, such as cytomegalovirus (CMV) and herpes simplex virus 2 (HSV2), remain unknown. Read More

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http://dx.doi.org/10.1111/aji.12840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978736PMC
May 2018
11 Reads

[The Spanish Society of Paediatric Infectious Diseases guidelines on the prevention, diagnosis and treatment of neonatal herpes simplex infections].

Authors:

An Pediatr (Barc) 2018 Jul 13;89(1):64.e1-64.e10. Epub 2018 Feb 13.

Neonatal herpes simplex virus infections are rare, but are associated with significant morbidity and mortality. Most newborns acquire herpes simplex virus infection in the peripartum period. For peripartum transmission to occur, women must be shedding the virus in their genital tracts symptomatically or asymptomatically around the time of delivery. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.01.004DOI Listing
July 2018
13 Reads

Herpes simplex virus type 2 IgG antibodies in sera of umbilical cord as a proxy for placental infection in asymptomatic pregnant women.

Am J Reprod Immunol 2018 04 10;79(4):e12824. Epub 2018 Feb 10.

Oncovirology Program, Instituto Nacional do Câncer (INCA), Rio de Janeiro, Brazil.

Problem: Herpes simplex virus type 2 (HSV-2) infection is one of the most prevalent diseases worldwide and is mainly sexually transmitted. When infecting pregnant women, HSV-2 is able to infect the placenta, can reach the fetus, and may affect the fetal development. We sought to determine the prevalence of HSV-2 infection and reactivation in asymptomatic pregnant women, the correlation between IgG in the maternal circulation and cord blood, and the correlation between circulating IgG, placental, and newborn infection (blood cord). Read More

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http://dx.doi.org/10.1111/aji.12824DOI Listing
April 2018
41 Reads

Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern?

Pediatr Infect Dis J 2018 08;37(8):806-813

From the Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Background: This article provides an update on the incidence of neonatal herpes, guideline adherence by health care professionals (HCP) and trends in genital herpes simplex virus (HSV) infection during pregnancy in the Netherlands.

Methods: Questionnaires were sent to all hospitals inquiring about numbers and characteristics of neonatal and maternal HSV infections, and guideline adherence between 2012 and 2015. Longitudinal trends were investigated from 1999 onward using survey data and Perinatal Registry of the Netherlands data (Perined). Read More

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http://dx.doi.org/10.1097/INF.0000000000001905DOI Listing
August 2018
13 Reads
2.723 Impact Factor

Invasive Obstetric Procedures and Cesarean Sections in Women With Known Herpes Simplex Virus Status During Pregnancy.

Open Forum Infect Dis 2017 6;4(4):ofx248. Epub 2017 Nov 6.

Department of Medicine, University of Washington, Seattle.

Background: Neonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (HSV) type 1 or 2 from the maternal genital tract at the time of vaginal delivery. Current guidelines recommend (1) cesarean delivery if maternal genital HSV lesions are present at the time of labor and (2) antiviral suppressive therapy for women with known genital herpes to decrease HSV shedding from the genital tract at the time of vaginal delivery. However, most neonatal infections occur in infants born to women without a history of genital HSV, making current prevention efforts ineffective for this group. Read More

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http://dx.doi.org/10.1093/ofid/ofx248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751035PMC
November 2017
42 Reads

Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068.

J Int AIDS Soc 2017 12;20(4)

Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, UK.

Introduction: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. Read More

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http://dx.doi.org/10.1002/jia2.25029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810346PMC
December 2017
36 Reads

[Endometrial dysfunction caused by chronic endometritis: сlinical and morphological aspects].

Arkh Patol 2017;79(6):22-29

Research Institute of Human Morphology, Moscow, Russia.

Aim: to determine the clinical and morphological aspects of endometrial dysfunction caused by chronic endometritis (CE).

Subjects And Methods: The study included 239 reproductive-aged patients: 93 were examined for abnormal uterine bleeding; 37 patients of them had a history of miscarriage and secondary infertility, 17 patients had primary infertility (Group 1). The remaining 105 patients with infertility were examined for future in vitro fertilization (Group 2). Read More

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http://www.mediasphera.ru/issues/arkhiv-patologii/2017/6/dow
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http://dx.doi.org/10.17116/patol201779622-29DOI Listing
April 2018
29 Reads

Cervical HSV-2 infection causes cervical remodeling and increases risk for ascending infection and preterm birth.

PLoS One 2017 30;12(11):e0188645. Epub 2017 Nov 30.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America.

Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708831PMC
December 2017
22 Reads

[Herpes and pregnancy: Guidelines for clinical practice - method and organization].

Gynecol Obstet Fertil Senol 2017 12 13;45(12):640-641. Epub 2017 Nov 13.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

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https://linkinghub.elsevier.com/retrieve/pii/S24687189173024
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http://dx.doi.org/10.1016/j.gofs.2017.10.010DOI Listing
December 2017
10 Reads

[Genital herpes and pregnancy: Epidemiology, clinical manifestations, prevention and screening. Guidelines for clinical practice from the French College of Gynecologists and Obstetrician (CNGOF)].

Authors:
O Picone

Gynecol Obstet Fertil Senol 2017 Dec 13;45(12):642-654. Epub 2017 Nov 13.

Department of Gynaecology and Obstetrics, hôpital Louis-Mourier, hôpitaux universitaires Paris Nord, 147, rue des Renouillets, 92700 Colombes, France. Electronic address:

Objectives: To analyze the consequences of genital herpes infections in pregnant women.

Methods: The PubMed database and the recommendations from the French and foreign obstetrical societies or colleges have been consulted.

Results: The symptomatology of herpes genital rash is often atypical (NP2) and not different during pregnancy (Professional consensus). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.002DOI Listing
December 2017
25 Reads

[Herpes and pregnancy: Guidelines for clinical practice - introduction].

Gynecol Obstet Fertil Senol 2017 12 11;45(12):639. Epub 2017 Nov 11.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

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https://linkinghub.elsevier.com/retrieve/pii/S24687189173024
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http://dx.doi.org/10.1016/j.gofs.2017.10.009DOI Listing
December 2017
7 Reads

[Neonatal herpes: Epidemiology, clinical manifestations and management. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)].

Authors:
L Renesme

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):691-704. Epub 2017 Nov 11.

Unité de néonatalogie soins intensifs-pédiatrie de maternité, centre Aliénor d'Aquitaine, groupe hospitalier Pellegrin, centre hospitalier universitaire de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France. Electronic address:

Objectives: To describe the epidemiology of neonatal herpes and its risk factors, clinical and paraclinic manifestations, propose guidelines for a newborn at risk of neonatal herpes, describe treatment modalities, describe post-natal transmission and its prevention.

Methods: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines.

Results: Neonatal herpes is rare (about 20 cases per year in France) and mainly due to HSV 1 (level of evidence LE3). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687189173023
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http://dx.doi.org/10.1016/j.gofs.2017.10.005DOI Listing
December 2017
13 Reads

[Management of pregnant women with recurrent herpes. Guidelines for clinical practice from the French College of Gynecologists, Obstetricians (CNGOF)].

Authors:
O Anselem

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):677-690. Epub 2017 Nov 11.

Maternité Port-Royal, université Paris Descartes, groupe hospitalier Cochin-Broca-Hôtel-Dieu, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; DHU risques et grossesse, PRES Sorbonne Paris Cité, 53, avenue de l'Observatoire, 75014 Paris, France. Electronic address:

Objective: To provide guidelines for the management of woman with genital herpes during pregnancy or labor and with known history of genital herpes.

Methods: MedLine and Cochrane Library databases search and review of the main foreign guidelines.

Results: Genital herpes ulceration during pregnancy in a woman with history of genital herpes correspond to a recurrence. Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.003DOI Listing
December 2017
13 Reads

[Genital herpes and pregnancy: Serological and molecular diagnostic tools. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)].

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):655-663. Epub 2017 Nov 11.

Laboratoire de virologie, hôpital Paul-Brousse, groupe hospitalier universitaire Paris-Sud, 12, rue Paul-Vaillant-Couturier, 94800 Villejuif, France. Electronic address:

Objectives: To describe serological and molecular tools available for genital and neonatal herpes, and their use in different clinical situations.

Methods: Bibliographic investigations from MedLine database and consultation of international clinical practice guidelines.

Results: Virological confirmation of genital herpes during pregnancy or neonatal herpes must rely on PCR (Professional consensus). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.004DOI Listing
December 2017
18 Reads

Prévention et prise en charge de l’infection herpétique au cours de la grossesse et de l’accouchement : recommandations pour la pratique clinique – texte des recommandations (texte court).

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):705-714. Epub 2017 Nov 11.

Service de gynécologie-obstétrique, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

Objective: Identify measures to diagnose, prevent and treat genital herpes infection during pregnancy and childbirth and neonatal infection.

Methods: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines.

Results: Genital herpes lesion is most often due to HSV2 (LE2). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.007DOI Listing
December 2017
34 Reads

[Management of pregnant women with first episode of genital herpes. Guidelines for clinical practice from the French college of gynecologists and obstetricians (CNGOF)].

Authors:
N Sananès

Gynecol Obstet Fertil Senol 2017 Dec 11;45(12):664-676. Epub 2017 Nov 11.

Service de gynécologie obstétrique, hôpitaux universitaires de Strasbourg, avenue Molière, BP 426, 67091 Strasbourg cedex, France; Unité Inserm UMR-S 1121 « Biomatériaux et Bioingénierie », 11, rue Humann, 67000 Strasbourg, France. Electronic address:

Objective: To provide guidelines for the management of first episode genital herpes during pregnancy and in the immediate postpartum period.

Methods: MedLine and Cochrane Library databases search and review of the main foreign guidelines.

Results: In case of first episode genital herpes during pregnancy, antiviral treatment with acyclovir (200mg 5 times daily) or valacyclovir (1000mg twice daily) for 5 to 10 days is recommended (grade C). Read More

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http://dx.doi.org/10.1016/j.gofs.2017.10.006DOI Listing
December 2017
22 Reads

Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis.

Eur J Obstet Gynecol Reprod Biol 2017 12 23;219:133. Epub 2017 Oct 23.

City Hospitals Sunderland NHS Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1016/j.ejogrb.2017.10.014DOI Listing
December 2017
19 Reads

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes: A Case-control Study.

Chin Med J (Engl) 2017 Oct;130(20):2416-2422

Department of Microbiology and Immunology, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Background: Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. Read More

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http://dx.doi.org/10.4103/0366-6999.216396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684638PMC
October 2017
47 Reads

Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model.

PLoS One 2017 5;12(10):e0185946. Epub 2017 Oct 5.

Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.

Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628903PMC
October 2017
88 Reads

Co-infection of human herpesvirus type 2 (HHV-2) and human immunodeficiency virus (HIV) among pregnant women in Rio de Janeiro, Brazil.

AIDS Care 2018 03 15;30(3):378-382. Epub 2017 Sep 15.

a Laboratório de Desenvolvimento Tecnológico em Virologia, Pavilhão Hélio e Peggy Pereira , Instituto Oswaldo Cruz , Rio de Janeiro - RJ , Brasil.

Pregnant women who are infected with the Human Immunodeficiency Virus (HIV) are particularly vulnerable to severe and recurrent infections with Human Herpesvirus 2 (HHV-2). Neonatal transmission of HHV-2 has been associated with malformations and neurological sequelae in infants, which makes it very important to perform antenatal monitoring for genital herpes. In the study, 134 pregnant women infected with HIV were tested for HHV-2 IgM and IgG using an enzyme-linked immunosorbent assay (ELISA) and had HHV-2 DNA analyzed by Real Time Polymerase Chain Reaction (qPCR). Read More

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http://dx.doi.org/10.1080/09540121.2017.1378798DOI Listing
March 2018
8 Reads

2017 European guidelines for the management of genital herpes.

Int J STD AIDS 2017 12 24;28(14):1366-1379. Epub 2017 Aug 24.

1 Department of Genitourinary Medicine, Southampton, UK.

Genital herpes is one of the commonest sexually transmitted infections worldwide. Using the best available evidence, this guideline recommends strategies for diagnosis, management, and follow-up of the condition as well as for minimising transmission. Early recognition and initiation of therapy is key and may reduce the duration of illness or avoid hospitalisation with complications, including urinary retention, meningism, or severe systemic illness. Read More

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http://dx.doi.org/10.1177/0956462417727194DOI Listing
December 2017
155 Reads

Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti.

BMC Infect Dis 2017 08 18;17(1):577. Epub 2017 Aug 18.

Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, 30329, USA.

Background: Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population. Read More

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http://dx.doi.org/10.1186/s12879-017-2674-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563013PMC
August 2017
28 Reads

Rubella, herpes simplex virus type 2 and preeclampsia.

Virol J 2017 07 26;14(1):142. Epub 2017 Jul 26.

Faculty of Medicine, University of Khartoum, P. O. Box 102, Khartoum, Sudan.

Background: Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.

Objective: The aim of the present study was to investigate the association between maternal seropositivity of rubella, Herpes simplex virus type 2 (HSV-2) and preeclampsia. Read More

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http://dx.doi.org/10.1186/s12985-017-0813-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530498PMC
July 2017
29 Reads

No. 208-Guidelines for the Management of Herpes Simplex Virus in Pregnancy.

J Obstet Gynaecol Can 2017 Aug;39(8):e199-e205

Montréal, QC.

Objective: To provide recommendations for the management of genital herpes infection in women who want to get pregnant or are pregnant and for the management of genital herpes in pregnancy and strategies to prevent transmission to the infant.

Outcomes: More effective management of complications of genital herpes in pregnancy and prevention of transmission of genital herpes from mother to infant.

Evidence: Medline was searched for articles published in French or English related to genital herpes and pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163173045
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http://dx.doi.org/10.1016/j.jogc.2017.04.016DOI Listing
August 2017
48 Reads

N 208-Directive clinique sur la prise en charge du virus de l’herpès simplex pendant la grossesse.

J Obstet Gynaecol Can 2017 Aug;39(8):e192-e198

Montréal (Québec).

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http://dx.doi.org/10.1016/j.jogc.2017.04.017DOI Listing
August 2017
29 Reads

Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control.

BMC Infect Dis 2017 07 6;17(1):471. Epub 2017 Jul 6.

Robert Koch Institute (RKI), Berlin, Germany.

Background: Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are scarce. A previous study found higher HSV1/2 seroprevalences in women in East Germany than in women in West Germany. Read More

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http://dx.doi.org/10.1186/s12879-017-2527-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500947PMC
July 2017
48 Reads