1,175 results match your criteria Genital Herpes in Pregnancy

40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?

Int J Mol Sci 2022 Mar 22;23(7). Epub 2022 Mar 22.

Department of Dermatology, Immunodermatology and Venereology, Medical University of Warsaw, Koszykowa 82a, 02-008 Warsaw, Poland.

Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in the host body for life. The course of infection with these viruses is often asymptomatic or mild and self-limiting, but in immunocompromised patients, such as solid organ or bone marrow transplant recipients, the course can be very severe or even life-threatening. Read More

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Health-related quality of life in individuals with genital herpes: a systematic review.

Health Qual Life Outcomes 2022 Feb 16;20(1):25. Epub 2022 Feb 16.

Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.

Background: There is a significant global burden of herpes simplex virus (HSV) related genital ulcer disease yet little is known about its impact on quality of life. This systematic review aimed to identify studies that quantitatively evaluated the effect of genital herpes on various aspects of health-related quality of life.

Methods: Six databases were searched (MEDLINE, EMBASE, NHS Economic Evaluation Database, Health Technology Assessment, Database of Abstracts of Reviews of Effects, Web of Science Core Collection) for primary quality of life and economic evaluations of genital herpes from January 1, 2000 to January 7, 2021. Read More

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February 2022

Healthcare resource utilisation pattern and costs associated with herpes simplex virus diagnosis and management: a systematic review.

BMJ Open 2022 Jan 4;12(1):e049618. Epub 2022 Jan 4.

School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia

Objectives: Little is known about the economic burden of herpes simplex virus (HSV) across countries. This article aims to summarise existing evidence on estimates of costs and healthcare resource utilisation associated with genital and neonatal HSV infection.

Design: Systematic literature review. Read More

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January 2022

Primary HSV-2 Infection in Early Pregnancy Results in Transplacental Viral Transmission and Dose-Dependent Adverse Pregnancy Outcomes in a Novel Mouse Model.

Viruses 2021 09 25;13(10). Epub 2021 Sep 25.

McMaster Immunology Research Centre, Michael G. DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON L8S 4L8, Canada.

Herpes simplex virus type 2 (HSV-2) infection affects 24 million births annually and is associated with adverse pregnancy outcomes, including neonatal herpes; however, the mechanisms underlying in utero transmission of HSV-2 are largely unknown. We examined the effects of primary HSV-2 infection during early pregnancy on gestational outcomes in a novel, clinically relevant mouse model. Pregnant C57BL/6 mice were infected intravaginally with 10-10 pfu/mL HSV-2 on gestation day (gd) 4. Read More

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September 2021

Factors associated with the prevalence of HIV, HSV-2, pregnancy, and reported sexual activity among adolescent girls in rural western Kenya: A cross-sectional analysis of baseline data in a cluster randomized controlled trial.

PLoS Med 2021 09 28;18(9):e1003756. Epub 2021 Sep 28.

Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom.

Background: Adolescence is a sensitive time for girls' sexual and reproductive health (SRH), as biological changes occur concurrently with heightening pressures for sexual activity. In western Kenya, adolescent girls are vulnerable to acquiring sexually transmitted infections (STIs), such as HIV and herpes simplex virus type 2 (HSV-2), and to becoming pregnant prior to reaching adulthood. This study examines associations between individual, household, and partner-related risk factors and the prevalence of sex, adolescent pregnancy, HIV, and HSV-2. Read More

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September 2021

Asian guidelines for genital herpes.

J Infect Chemother 2021 10 29;27(10):1389-1399. Epub 2021 Jul 29.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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October 2021

Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study.

Arch Dis Child Fetal Neonatal Ed 2022 Mar 13;107(2):188-192. Epub 2021 Jul 13.

Division of Neonatology, Department of Paediatrics, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Rheinland-Pfalz, Germany.

Objective: To assess incidence and burden of neonatal herpes simplex virus (HSV) infections and to explore possible transmission routes.

Methods: A 2-year prospective nationwide surveillance study performed in 2017 and 2018. All German paediatric departments (n=464 in 2017, n=441 in 2018) were contacted on a monthly basis to report potential cases of neonatal HSV infections. Read More

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Olena I Krotik

Wiad Lek 2021 ;74(4):896-901


Objective: The aim: To identify the characteristics of the vaginal microbiota, cervical and uterine flora in women with the past history of sexually transmitted infections.

Patients And Methods: Materials and methods: A prospective study and the analysis of the vaginal microbiota, cervical and uterine flora were conducted in 96 women of reproductive age with infertility after the past history of STIs, who planned to get pregnant using ART. Together they made up the group I (main group) and the CG included 30 women of reproductive age, who planned pregnancy without a compromised reproductive history. Read More

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Human Papillomavirus Infection at the Time of Delivery.

Cureus 2021 Jun 1;13(6):e15364. Epub 2021 Jun 1.

Biophysics Laboratory, Stefan S Nicolau Institute of Virology, Bucharest, ROU.

Human papillomavirus (HPV) is one of the most encountered viral etiologies of genital infections that are transmitted through the sexual route in sexually active females. In the genital area, condylomata acuminate warts and the Buschke-Loewenstein tumor (giant condyloma acuminatum) are described. These lesions are associated with benign HPV6 and HPV 11 types. Read More

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Neonatal Herpes Simplex Virus Disease: Updates and Continued Challenges.

Clin Perinatol 2021 06;48(2):263-274

Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Children's Harbor Building 308, 1600 7th Avenue South, Birmingham, AL 35233-1711, USA.

This article defines neonatal herpes simplex virus (HSV) disease and describes the progress over the past 40 years that has revolutionized the management of HSV disease in neonates to improve their outcomes. These advancements include the introduction of acyclovir in the 1980s, polymerase chain reaction (PCR) for the detection of HSV DNA in the 1990s, and recommendations on managing infants born to mothers with active genital lesions. Despite these advancements, however, there remain high morbidity and mortality in affected neonates, with need for continued improvement. Read More

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Assessing the Burden of Infant Deaths Due to Herpes Simplex Virus, Human Immunodeficiency Virus, and Congenital Syphilis: United States, 1995 to 2017.

Sex Transm Dis 2021 08;48(8S):S4-S10

From the Bureau of Sexually Transmitted Infections, New York City Department of Health and Mental Hygiene, Long Island City, NY.

Background: Despite advances in diagnosis and treatment, neonatal infection with herpes simplex virus (HSV) has a high case fatality rate. The national burden of neonatal HSV and associated deaths is unknown because this condition is not nationally notifiable. We investigated trends in HSV-related infant deaths compared with infant deaths from congenital syphilis (CS) and human immunodeficiency virus (HIV). Read More

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Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis.

Microb Pathog 2021 May 16;154:104802. Epub 2021 Mar 16.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract diseases. This infection affects 75% of women on at least one occasion over a lifetime. The present systematic review and meta-analysis is the first to determine the prevalence of vulvovaginal candidiasis in Iranian women. Read More

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Herpes simplex virus infection in pregnancy - An update.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 4;259:38-45. Epub 2021 Feb 4.

Emeritus Professor of Obstetrics and Gynaecology, Department of Health Sciences, University of Leicester, UK. Electronic address:

Herpes Simplex virus (HSV) infection is one of the most common sexually transmitted infections among women of the reproductive age. It is estimated to affect about 2-3% of pregnant women. Vertical transmission during pregnancy is rare occurring in less than 1% of cases but for those with active lesions or shedding the virus asymptomatically the risk of vertical transmission intrapartum is high. Read More

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[The role of herpesviruses in development of diseases of the urogenital tract and infertility in women].

Vopr Virusol 2021 Jan 7;65(6):317-325. Epub 2021 Jan 7.

Ivanovsky Institute of Virology of FSBI «National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya» of the Ministry of Health of Russia.

This review presents the data on the spreading of all known human herpesviruses (НHVs) in female urogenital tract. According to the WHO almost 500 million people worldwide suffer from genital infection caused by НHVs. НHVs were detected in various inflammatory diseases of female upper and lower genital tract (vaginitis and cervicitis), in extrauterine pregnancy (in fallopian tubes), in infertility (cervical channel, endometrium and ovaries). Read More

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January 2021

Lifetime Medical Costs of Genital Herpes in the United States: Estimates From Insurance Claims.

Sex Transm Dis 2021 04;48(4):266-272

From the Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Background: The purpose of this study was to estimate the lifetime direct medical costs per incident case of genital herpes in the United States.

Methods: We used medical claims data to construct a cohort of people continuously enrolled in insurance for at least 48 consecutive months between 2010 and 2018. From this cohort, we identified initial genital herpes diagnoses as well as the cost of related clinical visits and medication during the 36 months after an initial diagnosis. Read More

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Poloxamer Modified Chitosan Nanoparticles for Vaginal Delivery of Acyclovir.

Pharm Nanotechnol 2021 ;9(2):141-156

Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, 411018, Maharashtra, India.

Objective: The aim of the present study was to design a surface modified chitosan nanoparticle system for vaginal delivery of acyclovir for effective drug uptake into vaginal mucosa.

Methods: Acyclovir-loaded chitosan nanoparticles, with and without modification by poloxamer 407, were prepared by ionic gelation method. The effects of two independent variables, chitosan to sodium tripolyphosphate mass ratio (X1) and acyclovir concentration (X2), on drug entrapment in nanoparticles were studied using 32 full factorial design. Read More

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October 2021

Herpes Simplex Virus Serotyping in Pregnant Women With a History of Genital Herpes and an Outbreak in the Third Trimester of Pregnancy: A Cost-Effectiveness Analysis.

Obstet Gynecol 2021 01;137(1):63-71

School of Medicine, University of Colorado, Aurora, Colorado; and the Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.

Objective: To estimate whether serotyping women with a history of genital herpes simplex virus (HSV) and an outbreak during the third trimester of pregnancy is cost effective compared with no serotyping.

Methods: We designed a decision-analytic model using TreeAge Pro software to assess an approach of routine HSV serotyping in a theoretical cohort of 63,582 women (an estimate of the number of women in the United States with a history of genital HSV and an outbreak during the third trimester of pregnancy). Outcomes included mild, moderate, and severe neonatal HSV, neonatal death, costs, and quality-adjusted life-years (QALYs) for both the woman and neonate. Read More

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January 2021

[Herpes simplex virus infections during pregnancy: epidemiology, clinical presentation and management].

Virologie (Montrouge) 2020 Oct;24(5):315-324

Service de Maladies infectieuses, AP-HP. Centre - Université de Paris, Hôpital Necker-Enfants malades, Paris, France, Université de Paris, Paris, France.

The incidence of herpes simplex virus (HSV) neonatal infection is estimated to be 8.9 per 100,000 live births in Europe. Early treatment with intravenous acyclovir has transformed the prognosis but this infection remains severe since, despite the treatment, mortality is frequent in disseminated diseases and neurological sequelae are frequent when central nervous system is involved. Read More

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October 2020

Impact evaluation of scripted lesson plans for HIV-related content in a life orientation curriculum: results from two provinces in South Africa.

BMC Public Health 2020 Oct 14;20(1):1542. Epub 2020 Oct 14.

SADC Research Centre, Cape Town, South Africa, USA.

Background: Young people under age 25 years are a key population at risk of unintended pregnancies, HIV and other sexually transmitted infections. School-based programming, focusing on youth under 17 years is strategic given that many in this age group are in school or are required to be in school and spend a considerable amount of their time at school. Prior evaluations of school-based HIV prevention programs for young people often employed weak study designs or lacked biomarkers (e. Read More

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October 2020

Protection against herpes simplex virus type 2 infection in a neonatal murine model using a trivalent nucleoside-modified mRNA in lipid nanoparticle vaccine.

Vaccine 2020 11 9;38(47):7409-7413. Epub 2020 Oct 9.

Infectious Disease Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6073, USA. Electronic address:

Neonatal herpes is a dreaded complication of genital herpes infection in pregnancy. We recently compared two vaccine platforms for preventing genital herpes in female mice and guinea pigs and determined that HSV-2 glycoproteins C, D and E expressed using nucleoside-modified mRNA in lipid nanoparticles provided better protection than the same antigens produced as baculovirus proteins and administered with CpG and alum. Here we evaluated mRNA and protein immunization for protection against neonatal herpes. Read More

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November 2020

In Reply.

Obstet Gynecol 2020 10;136(4):851

American College of Obstetricians and Gynecologists, Washington, DC.

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October 2020

Management of Genital Herpes in Pregnancy: ACOG Practice Bulletinacog Practice Bulletin, Number 220.


Obstet Gynecol 2020 May;135(5):e193-e202

Genital herpes simplex virus (HSV) infection during pregnancy poses a risk to the developing fetus and newborn. Genital herpes is common in the United States. Among 14- to 49-year-old females, the prevalence of HSV-2 infection is 15. Read More

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Management of Genital Herpes in Pregnancy: ACOG Practice Bulletin Summary, Number 220.


Obstet Gynecol 2020 May;135(5):1236-1238

Genital herpes simplex virus (HSV) infection during pregnancy poses a risk to the developing fetus and newborn. Genital herpes is common in the United States. Among 14- to 49-year-old females, the prevalence of HSV-2 infection is 15. Read More

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Neonatal Herpes Simplex Virus: The Long Road to Improved Outcomes.

Neonatal Netw 2020 Mar;39(2):92-98

Herpes simplex virus (HSV) acquired during delivery places the neonate at risk for mortality or long-term neurodevelopmental disability. Exposure generally occurs from recurrent genital herpes infection, although primary infections result in the highest risk of neonatal disease. Neonates generally present in the second or third week of life with lesions. Read More

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Genital herpes and pregnancy: Evaluating practices and knowledge of French health care providers.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 26;249:84-91. Epub 2020 Feb 26.

Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Colombes, France; Université de Paris, Paris, France; Inserm IAME-U1137, Paris, France; Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), France. Electronic address:

Background: Genital herpes during pregnancy is a frequent occurrence, whereas infection of newborns is rare but likely severe. In the absence of specific national guidelines from the CNGOF (French National College of Gynaecologists and Obstetricians) in France until December 2017, we supposed that knowledge of health care providers on the topic was not up to date.

Objective: To assess health care provider knowledge of genital herpes and management practices during pregnancy, before the publication of national recommendations edited by the CNGOF. Read More

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High Incidence of Herpes Simplex Virus-1 in Cord Blood and Placenta Infection of Women in Southern Brazil.

Rev Bras Ginecol Obstet 2020 Jan 27;42(1):5-11. Epub 2020 Feb 27.

Molecular Biology Laboratory, School of Medicine, Universidade Federal do Rio Grande, Rio Grande, Brazil.

Objective:  Estimate the prevalence of human herpesvirus type 1 HSV-1 DNA in placental samples, its incidence in umbilical cord blood of newborns and the associated risk factors.

Methods:  Placental biopsies and umbilical cord blood were analyzed, totaling 480 samples, from asymptomatic parturients and their newborns at a University Hospital. Nested polymerase chain reaction (PCR) and gene sequencing were used to identify the virus; odds ratio (OR) and relative risk (RR) were performed to compare risk factors associated with this condition. Read More

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January 2020

[Genital herpes simplex virus infection in pregnancy].

Ugeskr Laeger 2020 01;182(5)

In this review, we discuss genital herpes - a common sexually transmitted infection, which can be transmitted to the baby during birth. Neonatal herpes is a rare but serious infection. In 2019, the Danish Society of Obstetrics and Gynecology revised the guideline for management of genital herpes in pregnancy. Read More

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January 2020

Prevention and treatment of neonatal herpes simplex virus infection.

Antiviral Res 2020 04 7;176:104721. Epub 2020 Feb 7.

Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death. Read More

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Widespread aplasia cutis due to congenital herpes simplex virus.

Clin Exp Dermatol 2020 Jul 5;45(5):664-665. Epub 2020 Feb 5.

Dermatology Department, Basildon and Thurrock University Hospital, Basildon, Essex, UK.

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