29 results match your criteria Genetics and Epigenetics [Journal]

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Comprehensive Evaluation of Commercial Bisulfite-Based DNA Methylation Kits and Development of an Alternative Protocol With Improved Conversion Performance.

Genet Epigenet 2018 22;10:1179237X18766097. Epub 2018 Mar 22.

Faculty of Natural Sciences and Technology, Department of Genetics/Epigenetics, Saarland University, Saarbrücken, Germany.

DNA methylation is the most studied epigenetic modification with a wide range of regulatory functions in mammalian genomes. It almost exclusively resides on CpG dinucleotides and, among others, plays important roles in early embryo development, onset, and maintenance of cancer. During the past 3 decades, many approaches have been developed to discriminate methylated from unmethylated DNA including antibody-based enrichment of methylated DNA, restriction enzyme-based, or hybridization-based methods. Read More

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http://dx.doi.org/10.1177/1179237X18766097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888801PMC
March 2018
2 Reads

Association of Tissue-Specific DNA Methylation Alterations with α-Thalassemia Southeast Asian Deletion.

Genet Epigenet 2017 15;9:1179237X17736107. Epub 2017 Nov 15.

Thalassemia Research Unit, Institute of Human Genetics, University of Phayao, Phayao, Thailand.

In the wild-type allele, DNA methylation levels of 10 consecutive CpG sites adjacent to the upstream 5'-breakpoint of α-thalassemia Southeast Asian (SEA) deletion are not different between placenta and leukocytes. However, no previous study has reported the map of DNA methylation in the SEA allele. This report aims to show that the SEA mutation is associated with DNA methylation changes, resulting in differential methylation between placenta and leukocytes. Read More

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http://dx.doi.org/10.1177/1179237X17736107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692129PMC
November 2017
6 Reads

Epigenetic Regulation of Gene Expression Induced by Butyrate in Colorectal Cancer: Involvement of MicroRNA.

Genet Epigenet 2017 25;9:1179237X17729900. Epub 2017 Sep 25.

Experimental Cancer Medicine Centre, Cardiff University, Cardiff, UK.

Colorectal cancer (CRC) is the third most common cause of cancer mortality globally. Development of CRC is closely associated with lifestyle, and diet may modulate risk. A Western-style diet is characterised by a high intake of red meat but low consumption of fruit, vegetables, and whole cereals. Read More

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http://journals.sagepub.com/doi/10.1177/1179237X17729900
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http://dx.doi.org/10.1177/1179237X17729900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617089PMC
September 2017
10 Reads

Consistency and Variability of DNA Methylation in Women During Puberty, Young Adulthood, and Pregnancy.

Genet Epigenet 2017 28;9:1179237X17721540. Epub 2017 Jul 28.

Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN, USA.

Prior DNA methylation (DNA-m) analyses have identified cytosine-phosphate-guanine (CpG) sites, which show either a significant change or consistency during lifetime. However, the proportion of CpGs that are neither significantly different nor consistent over time (indifferent CpGs) is unknown. We investigated the methylation dynamics, both longitudinal changes and consistency, in women from preadolescence to late pregnancy using DNA-m of peripheral blood cells. Read More

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http://dx.doi.org/10.1177/1179237X17721540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536379PMC
July 2017
41 Reads

DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.

Genet Epigenet 2016 28;8:59-67. Epub 2016 Nov 28.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Background: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment.

Methods: DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158).

Results: DMR levels were positively associated with internalizing ( = 0. Read More

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http://dx.doi.org/10.4137/GEG.S40538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127604PMC
November 2016
17 Reads

DNA Methylation of Cellular Retinoic Acid-Binding Proteins in Cervical Cancer.

Genet Epigenet 2016 10;8:53-57. Epub 2016 Nov 10.

Laboratorio de Biotecnología, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.

This study determined the methylation status of cellular retinoic acid-binding protein () gene promoters and associated them with demographic characteristics, habits, and the presence of human papilloma virus (HPV) in patients with cervical cancer (CC), low and high squamous intraepithelial lesions, and no intraepithelial lesion. Women (n = 158) were selected from the Colposcopy Clinic of Sanitary Jurisdiction II in Ciudad Juarez, Chihuahua, Mexico. Demographic characteristics and habit information were collected. Read More

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http://dx.doi.org/10.4137/GEG.S40847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106192PMC
November 2016
20 Reads

Epigenetics and Cellular Metabolism.

Genet Epigenet 2016 25;8:43-51. Epub 2016 Sep 25.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China.

Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external stimuli into transcriptional response. Read More

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http://dx.doi.org/10.4137/GEG.S32160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038610PMC
September 2016
13 Reads

Resetting Human Naïve Pluripotency.

Genet Epigenet 2016 4;8:37-41. Epub 2016 Aug 4.

Department of Molecular and Cellular Biology, University of California, Berkeley, CA, USA.

The rodent naive pluripotent state is believed to represent the preimplantation inner cell mass state of the developing blastocyst and can derive self-renewing pluripotent embryonic stem cells (ESCs) in vitro. Nevertheless, human ESCs exhibit epigenetic, metabolic, and transcriptomic characteristics more akin to primed pluripotent stem cells (PSCs) derived from the postimplantation epiblast. Understanding the genetic and epigenetic mechanisms that constrain human ESCs in the primed state is crucial for the human naive pluripotent state resetting and numerous applications in regenerative medicine. Read More

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http://dx.doi.org/10.4137/GEG.S38093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975245PMC
August 2016
34 Reads
1 Citation

The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences.

Genet Epigenet 2016 3;8:25-36. Epub 2016 Aug 3.

Cancer Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Genome Science Institute, Boston University School of Medicine, Boston, MA, USA.

The evolution process includes genetic alterations that started with prokaryotes and now continues in humans. A distinct difference between prokaryotic chromosomes and eukaryotic chromosomes involves histones. As evolution progressed, genetic alterations accumulated and a mechanism for gene selection developed. Read More

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http://dx.doi.org/10.4137/GEG.S31863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973776PMC
August 2016
46 Reads
3 Citations

Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population-A Mendelian Randomization Analysis.

Genet Epigenet 2016 24;8:15-24. Epub 2016 Jul 24.

Department of Mathematics and Statistics, Memorial University of Newfoundland, Canada.

A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as instruments was employed to assess the causal effect. Read More

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http://dx.doi.org/10.4137/GEG.S38289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959453PMC
August 2016
3 Reads

A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children.

Genet Epigenet 2016 29;8:7-14. Epub 2016 May 29.

Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.

Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0. Read More

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http://dx.doi.org/10.4137/GEG.S38307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887113PMC
June 2016
76 Reads

Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course.

Genet Epigenet 2016 24;8:1-6. Epub 2016 Feb 24.

Chief Physician Medicine/Oncology, St. Lukas Hospital Solingen, Germany.

The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case-control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, -4576A/C, +1619A/G, and +6362C/T) and malignant melanoma susceptibility and disease course. The study population consisted of 205 Caucasian patients who were diagnosed as having malignant melanoma and 208 healthy Caucasian controls. Read More

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http://dx.doi.org/10.4137/GEG.S31264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767130PMC
March 2016
8 Reads

Alkaline Phosphatase-Positive Immortal Mouse Embryo Fibroblasts Are Cells in a Transitional Reprogramming State Induced to Face Environmental Stresses.

Genet Epigenet 2015 28;7:33-41. Epub 2015 Dec 28.

Institute of Clinical Physiology (IFC), CNR, Pisa, Italy.; Tuscan Tumor Institute (ITT), Firenze, Italy.

In this study, we report that immortal mouse embryonic fibroblasts (I-MEFs) have a baseline level of cells positive for alkaline phosphatase (AP(+)) staining. Environmental stresses, including long-lasting growth in the absence of expansion and treatment with drugs, enhance the frequency of AP(+) I-MEFs. By adapting fast red AP staining to the sorting procedure, we separated AP(+) and AP(-) I-MEFs and demonstrated that the differentially expressed genes are consistent with a reprogrammed phenotype. Read More

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http://dx.doi.org/10.4137/GEG.S27696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694620PMC
January 2016
6 Reads

Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer.

Genet Epigenet 2015 2;7:19-32. Epub 2015 Dec 2.

Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Breast cancer (BC) is the most common cause of cancer-related death among women under the age of 50 years. Established biomarkers, such as hormone receptors (estrogen receptor [ER]/progesterone receptor) and human epidermal growth factor receptor 2 (HER2), play significant roles in the selection of patients for endocrine and trastuzumab therapies. However, the initial treatment response is often followed by tumor relapse with intrinsic resistance to the first-line therapy, so it has been expected to identify novel molecular markers to improve the survival and quality of life of patients. Read More

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http://dx.doi.org/10.4137/GEG.S35500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669075PMC
December 2015
5 Reads

Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.

Genet Epigenet 2015 11;7:5-17. Epub 2015 Oct 11.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA. ; Sanford-Burnham Medical Research Institute, Diabetes and Obesity Center, Lake Nona-Orlando, FL, USA. ; Florida Hospital Cancer Institute, Orlando, FL, USA.

In Type 1 diabetic (T1D) human monocytes, STAT5 aberrantly binds to epigenetic regulatory sites of two proinflammatory genes, CSF2 (encoding granulocyte-macrophage colony-stimulating factor) and PTGS2 (encoding prostaglandin synthase 2/cyclooxygenase 2). Bicongenic B6.NOD C11bxC1tb mice re-create this phenotype of T1D monocytes with only two nonobese diabetic (NOD) Idd subloci (130. Read More

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http://dx.doi.org/10.4137/GEG.S29696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603573PMC
October 2015
28 Reads

Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and α-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players.

Genet Epigenet 2015 20;7:1-4. Epub 2015 Sep 20.

Department of Coach Training, School of Physical Education and Sports, Gelisim University, Istanbul, Turkey.

Angiotensin-1 converting enzyme (ACE) gene and α-actinin-3 (ACTN3) gene polymorphisms are considered to be the most important candidate genes for genetic predisposition to human athletic performance. In the present study, we aimed to analyze the distribution of ACE and ACTN3 polymorphisms for the first time in male Turkish soccer players. In this prospective study, our cohort consisted of 25 professional players, all with Turkish ancestry. Read More

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http://journals.sagepub.com/doi/10.4137/GEG.S31479
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http://dx.doi.org/10.4137/GEG.S31479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578552PMC
October 2015
6 Reads

Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.

Genet Epigenet 2014 14;6:37-44. Epub 2014 Sep 14.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA. ; Department of Pathology, Duke University Medical Center, Durham, NC, USA.

In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular disease, and cancers in adulthood. We examined associations between prenatal maternal stress and PTB, evaluating the role of DNA methylation at imprint regulatory regions. We enrolled women from prenatal clinics in Durham, NC. Read More

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http://dx.doi.org/10.4137/GEG.S18067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251062PMC
December 2014
11 Reads

Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico.

Genet Epigenet 2014 22;6:31-6. Epub 2014 Jul 22.

Reumatología, Hospital General Dr. Agustín O'Horán, Servicios de Salud de Yucatán (SSY). Mérida, Yucatán, México.

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors such as copy number variation (CNV) of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. Read More

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http://dx.doi.org/10.4137/GEG.S16707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251061PMC
December 2014
13 Reads

Effect of FTO Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population.

Genet Epigenet 2014 11;6:21-30. Epub 2014 Jun 11.

Department of Mathematics and Statistics, Memorial University, St. John's, NL, Canada.

Objective: To explore the effect of FTO gene and physical activity interaction on trunk fat percentage.

Design And Methods: Subjects are 3,004 individuals from Newfoundland and Labrador whose trunk fat percentage and physical activity were recorded, and who were genotyped for 11 single-nucleotide polymorphisms (SNPs) in the FTO gene. Subjects were stratified by gender. Read More

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http://dx.doi.org/10.4137/GEG.S14957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262999PMC
December 2014
4 Reads

Use of epigenetic drugs in disease: an overview.

Genet Epigenet 2014 27;6:9-19. Epub 2014 May 27.

Cancer Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Epigenetic changes such as DNA methylation and histone methylation and acetylation alter gene expression at the level of transcription by upregulating, downregulating, or silencing genes completely. Dysregulation of epigenetic events can be pathological, leading to cardiovascular disease, neurological disorders, metabolic disorders, and cancer development. Therefore, identifying drugs that inhibit these epigenetic changes are of great clinical interest. Read More

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http://dx.doi.org/10.4137/GEG.S12270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251063PMC
December 2014
8 Reads

Bioinformatic Dissecting of TP53 Regulation Pathway Underlying Butyrate-induced Histone Modification in Epigenetic Regulation.

Genet Epigenet 2014 17;6:1-7. Epub 2014 Mar 17.

Bovine Functional Genomics Laboratory, Agricultural Research Service, USDA. Beltsville, MD, USA.

Butyrate affects cell proliferation, differentiation, and motility. Butyrate inhibits histone deacetylase (HDAC) activities and induces cell-cycle arrest and apoptosis. TP53 is one of the most active upstream regulators discovered by ingenuity pathways analysis (IPA) in our RNA-sequencing data set. Read More

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http://dx.doi.org/10.4137/GEG.S14176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251064PMC
December 2014
4 Reads

Epigenetics of autoantigens: new opportunities for therapy of autoimmune diseases.

Genet Epigenet 2013 29;5:63-70. Epub 2013 Oct 29.

Immunopathology and therapeutic chemistry/Laboratory of excellence MEDALIS, Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France.

The field of epigenetics requires that traditional divisions between scientific disciplines give way to cross-fertilization of concepts and ideas from different areas of investigation. Such is the case with research in autoimmunity. Recent discoveries of stimuli that induce autoimmunity reveal that epigenetic marks of autoantigens are recognized by autoreactive B and T cell receptors. Read More

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http://dx.doi.org/10.4137/GEG.S12144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222337PMC
December 2014
4 Reads

Changes in methylation patterns of kiss1 and kiss1r gene promoters across puberty.

Genet Epigenet 2013 24;5:51-62. Epub 2013 Oct 24.

Centre for Neuroendocrinology, Centre for Reproduction and Genomics, Gravida: National Centre for Growth and Development, Department of Anatomy, University of Otago School of Medical Sciences, Dunedin, New Zealand.

The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 or Kiss1r fail to go through puberty. The timing of puberty is dependent on environmental factors, and malleability in puberty timing suggests a mechanism that can translate environmental signals into patterns of Kiss1/Kiss1r gene expression. Read More

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http://dx.doi.org/10.4137/GEG.S12897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222338PMC
December 2014
7 Reads

DNA demethylation pathways: recent insights.

Authors:
Cong-Jun Li

Genet Epigenet 2013 28;5:43-9. Epub 2013 Jul 28.

USDA, Agricultural Research Service, Bovine Functional Genomics Laboratory, Beltsville, MD, USA.

DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell differentiation. Until recently, it was still unclear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether or not active demethylating activity is involved. Even the role of molecules and the mechanisms underlying the processes of active demethylation itself is blurred. Read More

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http://dx.doi.org/10.4137/GEG.S12143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222334PMC
December 2014
6 Reads

Unexplored potentials of epigenetic mechanisms of plants and animals-theoretical considerations.

Genet Epigenet 2013 30;5:23-41. Epub 2013 Jun 30.

Department of Pathophysiology and Gerontology, Medical School, and Szentagothai Res Centre, University of Pecs, Pecs, Hungary. ; Department of Physiology, New York Medical College, Valhalla NY, USA.

Morphological and functional changes of cells are important for adapting to environmental changes and associated with continuous regulation of gene expressions. Genes are regulated-in part-by epigenetic mechanisms resulting in alternating patterns of gene expressions throughout life. Epigenetic changes responding to the environmental and intercellular signals can turn on/off specific genes, but do not modify the DNA sequence. Read More

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http://dx.doi.org/10.4137/GEG.S11752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222336PMC
December 2014
7 Reads

Loss of Imprinting of IGF2 Gene in the Chorionic Tissues of Spontaneously Eliminated Human Embryos.

Genet Epigenet 2013 10;5:17-22. Epub 2013 Mar 10.

Rzeshow University of Technology, Poland.

Insulin-like growth factor-2 (IGF-2) is a mitogen, growth and differentiation modulator for many cell types. It is mainly expressed during the prenatal development, and its activity strongly depends on the genomic imprinting. Genomic imprinting in the chorionic tissues of spontaneously eliminated human embryos has been studied on the model of 820-AG (Apa1) of the IGF-2 gene locus. Read More

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http://dx.doi.org/10.4137/GEG.S11460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222333PMC
December 2014
4 Reads

Epigenetic effect of chronic stress on dopamine signaling and depression.

Genet Epigenet 2013 10;5:11-6. Epub 2013 Feb 10.

Biotechnology and Genetic Engineering Discipline, Khulna University.

Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factors lead many drugs to target Dopamine receptors in treating depressive disorders. Read More

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http://dx.doi.org/10.4137/GEG.S11016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222332PMC
December 2014
4 Reads

Acute psychosocial stress-mediated changes in the expression and methylation of perforin in chronic fatigue syndrome.

Genet Epigenet 2013 28;5:1-9. Epub 2013 Jan 28.

Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Perforin (PRF1) is essential for immune surveillance and studies report decreased perforin in chronic fatigue syndrome (CFS), an illness potentially associated with stress and/or infection. We hypothesize that stress can influence regulation of PRF1 expression, and that this regulation will differ between CFS and non-fatigued (NF) controls. We used the Trier Social Stress Test (TSST) as a standardized acute psychosocial stress, and evaluated its effect on PRF1 expression and methylation in CFS (n = 34) compared with NF (n = 47) participants. Read More

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http://dx.doi.org/10.4137/GEG.S10944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222335PMC
December 2014
3 Reads

UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.

Genet Epigenet 2010 Jan;2009(2):29-36

CNRS UMR 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, 74 route du Rhin, B.P. 60024, 67401 Illkirch Cedex, France.

Epigenetics is the study of the transmission of cell memory through mitosis or meiosis that is not based on the DNA sequence. At the molecular level the epigenetic memory of a cell is embedded in DNA methylation, histone post-translational modifications, RNA interference and histone isoform variation. There is a tight link between histone post-translational modifications (the histone code) and DNA methylation, as modifications of histones contribute to the establishment of DNA methylation patterns and vice versa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106981PMC
January 2010
17 Reads
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