108,898 results match your criteria Genes chromosomes & cancer[Journal]


Integrating genetic and physical positions of the anthracnose resistance genes described in bean chromosomes Pv01 and Pv04.

PLoS One 2019 14;14(2):e0212298. Epub 2019 Feb 14.

Plant Genetic Group, Area of Horticultural and Forest Crops, SERIDA, Villaviciosa Asturias, Spain.

A complex landscape of anthracnose resistance genes (Co-) located at the telomeric regions of the bean chromosomes Pv01 and Pv04 has been reported. The aim of this work was to investigate the genetic and physical positions of genes conferring resistance to races 6, 38, 39, 357, 65, and 73 as well as the relationships among the resistance genes identified herein and the previously described Co- genes in these telomeric regions. The linkage analysis using a genetic map of 497 SNPs from the recombinant inbred line population Xana/BAT93 revealed that the gene conferring resistance to race 65 in cultivar Xana (Co-165-X) was located in the Co-1 cluster, at the distal end of chromosome Pv01. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212298PLOS
February 2019

In-silico study of biotic and abiotic stress-related transcription factor binding sites in the promoter regions of rice germin-like protein genes.

PLoS One 2019 14;14(2):e0211887. Epub 2019 Feb 14.

Department of Agricultural and Food Engineering, Indian Institute of Technology Kharagpur, Kharagpur, Paschim Medinipur, West Bengal, India.

Germin-like proteins (GLPs) are involved in biotic and abiotic stress tolerance in different plant species. Rice (Oryza sativa L.) genome contains about 40 GLP family member proteins in nine chromosomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211887PLOS
February 2019

Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse.

PLoS One 2019 14;14(2):e0203099. Epub 2019 Feb 14.

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States of America.

Long-range associations between enhancers and their target gene promoters have been shown to play critical roles in executing genome function. Recent variations of chromosome capture technology have revealed a comprehensive view of intra- and interchromosomal contacts between specific genomic sites. The locus control region of the β-globin genes (β-LCR) is a super-enhancer that is capable of activating all of the β-like globin genes within the locus in cis through physical interaction by forming DNA loops. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203099PLOS
February 2019

Genome-Wide Association Mapping and Genomic Prediction Analyses Reveal the Genetic Architecture of Grain Yield and Flowering Time Under Drought and Heat Stress Conditions in Maize.

Front Plant Sci 2018 30;9:1919. Epub 2019 Jan 30.

International Maize and Wheat Improvement Center, Texcoco, Mexico.

Drought stress (DS) is a major constraint to maize yield production. Heat stress (HS) alone and in combination with DS are likely to become the increasing constraints. Association mapping and genomic prediction (GP) analyses were conducted in a collection of 300 tropical and subtropical maize inbred lines to reveal the genetic architecture of grain yield and flowering time under well-watered (WW), DS, HS, and combined DS and HS conditions. Read More

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http://dx.doi.org/10.3389/fpls.2018.01919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363715PMC
January 2019

The Importance of Conserved Serine for C-Terminally Encoded Peptides Function Exertion in Apple.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an, Shandong 271018, China.

Background: The C-terminally encoded peptide (CEP) family has been shown to play vital roles in plant growth. Although a genome-wide analysis of this family has been performed in Arabidopsis, little is known regarding CEPs in apple ().

Methods: Here, a comprehensive bioinformatics approach was applied to identify MdCEPs in apple, and 12 genes were identified and distributed on 6 chromosomes. Read More

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http://dx.doi.org/10.3390/ijms20030775DOI Listing
February 2019

Advances in understanding salt tolerance in rice.

Theor Appl Genet 2019 Feb 13. Epub 2019 Feb 13.

ICAR-National Bureau of Plant Genetic Resources, IARI Campus, Pusa, New Delhi, 110012, India.

Key Message: This review presents a comprehensive overview of the recent research on rice salt tolerance in the areas of genomics, proteomics, metabolomics and chemical genomics. Salinity is one of the major constraints in rice cultivation globally. Traditionally, rice is a glycophyte except for a few genotypes that have been widely used in salinity tolerance breeding of rice. Read More

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http://dx.doi.org/10.1007/s00122-019-03301-8DOI Listing
February 2019
3.790 Impact Factor

Additional Sources of Broad-Spectrum Resistance to Puccinia coronata f. sp. avenae from Canadian Accessions of Avena barbata.

Authors:
M L Carson

Plant Dis 2010 Dec;94(12):1405-1410

United States Department of Agriculture-Agricultural Research Service, Cereal Disease Lab, University of Minnesota, St. Paul 55108.

Crown rust (Puccinia coronata f. sp. avenae) is considered the most damaging disease of oat and the use of race-specific seedling (Pc) genes for resistance has been the primary means of control. Read More

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http://dx.doi.org/10.1094/PDIS-07-10-0517DOI Listing
December 2010

Karyotype Analysis of Four Blind Snake Species (Reptilia: Squamata: Scolecophidia) and Karyotypic Changes in Serpentes.

Cytogenet Genome Res 2019 Feb 13. Epub 2019 Feb 13.

The suborder Serpentes is divided into 2 infraorders, Scolecophidia and Alethinophidia, which diverged at an early stage of snake diversification. In this study, we examined karyotypes of 4 scolecophidian species (Letheobia simonii, Xerotyphlops vermicularis, Indotyphlops braminus, and Myriopholis macrorhyncha) and performed FISH with 18S-28S rDNA as well as microchromosomal and Z chromosome-linked genes of Elaphe quadrivirgata (Alethinophidia) to investigate the karyotype evolution in the scolecophidian lineage. Diploid chromosome numbers of X. Read More

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http://dx.doi.org/10.1159/000496554DOI Listing
February 2019

TaBT1 affecting starch synthesis and thousand kernel weight, underwent strong selection during wheat improvement.

J Exp Bot 2019 Feb 7. Epub 2019 Feb 7.

Key Laboratory of Crop Gene Resources and Germplasm Enhancement, Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China.

BRITTLE1 (BT1), responsible for unidirectional transmembrane transport of ADP-glucose, plays a pivotal role in starch synthesis of cereal grain. In this study, we isolated three TaBT1 homoeologous genes located on chromosomes 6A, 6B and 6D in common wheat. TaBT1 was mainly expressed in developing grains and knockdown of TaBT1 in common wheat exhibited a decrease in grain size, thousand kernel weight (TKW) and grain total starch content. Read More

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http://dx.doi.org/10.1093/jxb/erz032DOI Listing
February 2019

Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, INF440, Heidelberg, Germany.

Study Question: Which Y genes mapped to the 'Gonadoblastoma Y (GBY)' locus on human Y chromosome are expressed in germ cells of individuals with some Differences of Sexual Development (DSD) and a Y chromosome in their karyotype (DSD-XY groups)?

Summary Answer: The GBY candidate genes DDX3Y and TSPY are expressed in the germ cells of DSD-XY patients from distinct etiologies: patients with mixed gonadal dysgenesis (MGD) and sex chromosome mosaics (45,X0/46,XY; 46,XX/46,XY); patients with complete androgen insensitivity (CAIS), patients with complete gonadal dysgenesis (CGD; e.g. Swyer syndrome). Read More

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https://academic.oup.com/humrep/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/humrep/dez004DOI Listing
February 2019
1 Read

Genetic analysis of tomato root colonization by arbuscular mycorrhizal fungi.

Ann Bot 2019 Feb 9. Epub 2019 Feb 9.

Université catholique de Louvain, Earth and Life Institute, Mycology, Croix du Sud, Louvain-la-Neuve, Belgium.

Background And Aims: Arbuscular mycorrhizal fungi (AMF) play an important role in plant nutrition and protection against pests and diseases, as well as in soil structuration, nutrient cycling and, generally speaking, in sustainable agriculture, particularly under drought, salinity and low input or organic agriculture. However, little is known about the genetics of the AMF-plant association in tomato. The aim of this study was the genetic analysis of root AMF colonization in tomato via the detection of the quantitative trait loci (QTLs) involved. Read More

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http://dx.doi.org/10.1093/aob/mcy240DOI Listing
February 2019

Comprehensive genome-wide analysis of the pear (Pyrus bretschneideri) laccase gene (PbLAC) family and functional identification of PbLAC1 involved in lignin biosynthesis.

PLoS One 2019 12;14(2):e0210892. Epub 2019 Feb 12.

School of Life Science, Anhui Agricultural University, Hefei, China.

The content and size of stone cell clusters affects the quality of pear fruit, and monolignol polymerization and deposition in the cell walls constitute a required step for stone cell formation. Laccase (LAC) is the key enzyme responsible for the polymerization of monolignols. However, there are no reports on the LAC family in pear (Pyrus bretschneideri), and the identity of the members responsible for lignin synthesis has not been clarified. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210892PLOS
February 2019

Production of functional recombinant cyclic citrullinated peptide monoclonal antibody in transgenic rice cell suspension culture.

Transgenic Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular Biology, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea.

Cyclic citrullinated peptide (CCP) antibody has been shown recently to be a promising marker for early detection and diagnosis of rheumatoid arthritis (RA). In order to exploit newly developed therapies for RA, early intervention is crucial in preventing irreversible joint damage. Here, we describe use of a plant expression system to produce a CCP antibody that could be used in the early diagnosis of RA. Read More

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http://dx.doi.org/10.1007/s11248-019-00113-wDOI Listing
February 2019

Sequence Expression of Supernumerary B Chromosomes: Function or Fluff?

Genes (Basel) 2019 Feb 8;10(2). Epub 2019 Feb 8.

W. M. Keck Science Department of Claremont McKenna, Pitzer, and Scripps Colleges, Claremont, CA 91711, USA.

B chromosomes are enigmatic heritable elements found in the genomes of numerous plant and animal species. Contrary to their broad distribution, most B chromosomes are non-essential. For this reason, they are regarded as genome parasites. Read More

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http://dx.doi.org/10.3390/genes10020123DOI Listing
February 2019

Genome-wide Identification, Expression Profiling and Evolutionary Analysis of Auxin Response Factor Gene Family in Potato (Solanum tuberosum Group Phureja).

Sci Rep 2019 Feb 11;9(1):1755. Epub 2019 Feb 11.

State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

Auxin response factors (ARFs) play central roles in conferring auxin-mediated responses through selection of target genes in plants. Despite their physiological importance, systematic analysis of ARF genes in potato have not been investigated yet. Our genome-wide analysis identified 20 StARF (Solanum tuberosum ARF) genes from potato and found that they are unevenly distributed in all the potato chromosomes except chromosome X. Read More

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http://www.nature.com/articles/s41598-018-37923-7
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http://dx.doi.org/10.1038/s41598-018-37923-7DOI Listing
February 2019
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Cytogenetic and agronomic characterization of intergeneric hybrids between Saccharum spp. hybrid and Erianthus arundinaceus.

Sci Rep 2019 Feb 11;9(1):1748. Epub 2019 Feb 11.

Tropical Agriculture Research Front, Japan International Research Center for Agricultural Sciences, Ishigaki, 907-0002, Japan.

In sugarcane (Saccharum spp. hybrid) breeding, introgression of useful genes via intergeneric hybridization is a powerful strategy for improving the crop productivity. Erianthus arundinaceus shows great potential in terms of useful traits; however, little is known about the cytogenetic and agronomic characteristics of intergeneric hybrids between these two species. Read More

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http://dx.doi.org/10.1038/s41598-018-38316-6DOI Listing
February 2019

A novel variant of Gh_D02G0276 is required for root-knot nematode resistance on chromosome 14 (D02) in Upland cotton.

Theor Appl Genet 2019 Feb 11. Epub 2019 Feb 11.

Crop Science Research Laboratory, Genetics and Precision Agriculture Research Unit, USDA-ARS, 150 Twelve Lane, Mississippi State, MS, 39762, USA.

Key Message: MAGIC population sequencing and virus-induced gene silencing identify Gh_D02G0276 as a novel root-knot nematode resistance gene on chromosome 14 in Upland cotton. The southern root-knot nematode [RKN; Meloidogyne incognita (Kofoid & White)] remains the primary yield-limiting biotic stress to Upland cotton (Gossypium hirsutum L.) throughout the southeastern USA. Read More

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http://dx.doi.org/10.1007/s00122-019-03289-1DOI Listing
February 2019

Genome-wide identification and comparative evolutionary analysis of the Dof transcription factor family in physic nut and castor bean.

Authors:
Zhi Zou Xicai Zhang

PeerJ 2019 5;7:e6354. Epub 2019 Feb 5.

Danzhou Investigation & Experiment Station of Tropical Crops, Ministry of Agriculture and Rural Affairs, Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China.

DNA-binding with one finger (Dof) proteins comprise a plant-specific transcription factor family involved in plant growth, development and stress responses. This study presents a genome-wide comparison of Dof family genes in physic nut () and castor bean (), two Euphorbiaceae plants that have not experienced any recent whole-genome duplication. A total of 25 or 24 Dof genes were identified from physic nut and castor genomes, respectively, where JcDof genes are distributed across nine out of 11 chromosomes. Read More

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http://dx.doi.org/10.7717/peerj.6354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368027PMC
February 2019

Early detection of the PAX3-FOXO1 fusion gene in circulating tumor-derived DNA in a case of alveolar rhabdomyosarcoma.

Genes Chromosomes Cancer 2019 Feb 10. Epub 2019 Feb 10.

Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

Cell-free DNA (cfDNA), which are small DNA fragments in blood derived from dead cells including tumor cells, could serve as useful biomarkers and provide valuable genetic information about the tumors. cfDNA is now used for the genetic analysis of several types of cancers, as a surrogate for tumor biopsy, designated as "liquid biopsy." Rhabdomyosarcoma (RMS), the most frequent soft tissue tumor in childhood, can arise in any part of the body, and radiological imaging is the only available method for estimating the tumor burden, because no useful specific biological markers are present in the blood. Read More

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http://doi.wiley.com/10.1002/gcc.22734
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http://dx.doi.org/10.1002/gcc.22734DOI Listing
February 2019
4 Reads

Chromosomal and molecular characterization of 5S rRNA genes in the North American abalones Haliotis rufescens Swainson (red abalone) and H. fulgens Philippi (blue abalone).

Gene 2019 Feb 7. Epub 2019 Feb 7.

Aquaculture Genetics & Breeding Laboratory, Centro de Investigaciones Biológicas del Noroeste, Av. Instituto Politécnico Nacional 195, Col. Playa Palo de Sta. Rita, La Paz, BCS 23096, Mexico. Electronic address:

Abalone is an extremely valuable food source derived from cultured and wild animals, the later from populations under intense fishing exploitation and of high conservation value. As part of a long-term study to characterize genes from abalone that can be used as markers for hybrids certification, we characterised 5S ribosomal DNA (5S rDNA) in red abalone (Haliotis rufescens) and blue abalone (H. fulgens). Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.003DOI Listing
February 2019

Nucleolar Expression and Chromosomal Associations in Robertsonian Spermatocytes of .

Genes (Basel) 2019 Feb 6;10(2). Epub 2019 Feb 6.

Programa Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.

We studied and compared the nucleolar expression or nucleoli from specific bivalents in spermatocytes of the standard 2n=40, of Robertsonian (Rb) homozygotes 2n = 24 and heterozygotes 2n = 32. We analyzed 200 nuclear microspreads of each specific nucleolar chromosome and spermatocyte karyotype, using FISH to identify specific nucleolar bivalents, immunofluorescence for both fibrillarin of the nucleolus and the synaptonemal complex of the bivalents, and DAPI for heterochromatin. There was nucleolar expression in all the chromosomal conditions studied. Read More

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http://dx.doi.org/10.3390/genes10020120DOI Listing
February 2019

The first chromosome-level genome for a marine mammal as a resource to study ecology and evolution.

Mol Ecol Resour 2019 Feb 8. Epub 2019 Feb 8.

BGI-Qingdao, BGI-Shenzhen, Qingdao, Shandong Province, 266555, China.

Marine mammals are important models for studying convergent evolution and aquatic adaption, thus reference genomes of marine mammals can provide evolutionary insights. Here, we present the first chromosome-level marine mammal genome assembly based on the data generated by the BGISEQ-500 platform, for a stranded female sperm whale (Physeter macrocephalus). Using this reference genome, we performed chromosome evolution analysis of sperm whale including constructing ancestral chromosomes, identifying chromosome rearrangement events and comparison with cattle chromosomes, which provides a resource for exploring marine mammal adaptation and speciation. Read More

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http://dx.doi.org/10.1111/1755-0998.13003DOI Listing
February 2019
1 Read
3.712 Impact Factor

Analysis of Anasplatyrhynchos genome resequencing data reveals genetic signatures of artificial selection.

PLoS One 2019 8;14(2):e0211908. Epub 2019 Feb 8.

Tropical Crop Genetic Resource Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, P.R. China.

Three artificially selected duck populations (AS), higher lean meat ratios (LTPD), higher fat ratios (FTPD) and higher quality meat (CMD), have been developed in China, providing excellent populations for investigation of artificial selection effects. However, the genetic signatures of artificial selection are unclear. In this study, we sequenced the genome sequences of these three artificially selected populations and their ancestral population (mallard, M). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211908PLOS
February 2019

Comprehensive structural variation genome map of individuals carrying complex chromosomal rearrangements.

PLoS Genet 2019 Feb 8;15(2):e1007858. Epub 2019 Feb 8.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Complex chromosomal rearrangements (CCRs) are rearrangements involving more than two chromosomes or more than two breakpoints. Whole genome sequencing (WGS) allows for outstanding high resolution characterization on the nucleotide level in unique sequences of such rearrangements, but problems remain for mapping breakpoints in repetitive regions of the genome, which are known to be prone to rearrangements. Hence, multiple complementary WGS experiments are sometimes needed to solve the structures of CCRs. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007858DOI Listing
February 2019

PUMILIO hyperactivity drives premature aging of -deficient mice.

Elife 2019 Feb 8;8. Epub 2019 Feb 8.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.

Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here we investigated the physiologic function of the conserved lncRNA . Deletion of in mice results in genomic instability and mitochondrial dysfunction, leading to a dramatic multi-system degenerative phenotype resembling premature aging. Read More

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http://dx.doi.org/10.7554/eLife.42650DOI Listing
February 2019
1 Read

Identification of non-specific Lipid Transfer Protein gene family members in Solanum lycopersicum and insights into the features of Sola l 3 protein.

Sci Rep 2019 Feb 7;9(1):1607. Epub 2019 Feb 7.

Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy.

Non-specific lipid transfer proteins (nsLTPs) are characterized by an eight-cysteine motif backbone that is stabilized by four disulphide bonds. The strong interest towards this protein family is mainly due to the fact that nsLTPs are involved in many biological processes and have been identified as major human allergens. Since tomato (Solanum lycopersicum L. Read More

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http://dx.doi.org/10.1038/s41598-018-38301-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367377PMC
February 2019

In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion.

BMC Genomics 2019 Feb 7;20(1):118. Epub 2019 Feb 7.

Instituto Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz-Pernambuco), Recife, Pernambuco, Brazil.

Background: The leishmaniasis are parasitic diseases caused by protozoans of the genus Leishmania, highly divergent eukaryotes, characterized by unique biological features. To survive in both the mammalian hosts and insect vectors, these pathogens make use of a number of mechanisms, many of which are associated with parasite specific proteases. The metalloprotease GP63, the major Leishmania surface antigen, has been found to have multiple functions required for the parasite's survival. Read More

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http://dx.doi.org/10.1186/s12864-019-5465-zDOI Listing
February 2019

Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum.

BMC Genomics 2019 Feb 7;20(1):120. Epub 2019 Feb 7.

Department of Plant and Microbial Biology, University of Minnesota, St. Paul, MN, USA.

Background: Genes involved in production of secondary metabolites (SMs) in fungi are exceptionally diverse. Even strains of the same species may exhibit differences in metabolite production, a finding that has important implications for drug discovery. Unlike in other eukaryotes, genes producing SMs are often clustered and co-expressed in fungal genomes, but the genetic mechanisms involved in the creation and maintenance of these secondary metabolite biosynthetic gene clusters (SMBGCs) remains poorly understood. Read More

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http://dx.doi.org/10.1186/s12864-018-5399-xDOI Listing
February 2019

Integrative analysis reveals driver long non-coding RNAs in osteosarcoma.

Medicine (Baltimore) 2019 Feb;98(6):e14302

Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University.

Transcriptome profiling of osteosarcoma (OS) by next generation sequencing technology (NGS) has been broadly performed by previous researches, which uncovers a large number protein-coding driver genes, facilitates our understanding of the molecular mechanisms of OS formation, progression and metastasis. Recently, more and more researchers realize the importance of long non-coding RNAs (lncRNAs) on the development of OS. However, few studies focus on discovering driver lncRNAs. Read More

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http://dx.doi.org/10.1097/MD.0000000000014302DOI Listing
February 2019

Complex epigenetic regulation of alkaloid biosynthesis and host interaction by heterochromatin protein I in a fungal endophyte-plant symbiosis.

Fungal Genet Biol 2019 Feb 4;125:71-83. Epub 2019 Feb 4.

School of Fundamental Sciences and the BioProtection Research Centre, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand. Electronic address:

Epichloë festucae forms mutualistic symbiotic interactions with grasses of the Lolium and Festuca genera. Protection from insect and mammalian herbivory are the best-documented host benefits of these associations. The two main classes of anti-mammalian alkaloids synthesized by E. Read More

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http://dx.doi.org/10.1016/j.fgb.2019.02.001DOI Listing
February 2019
1 Read

Expansion of genes in the genome induces characteristic floral scent production.

Hortic Res 2019 1;6:24. Epub 2019 Feb 1.

1Beijing Key Laboratory of Ornamental Plants Germplasm Innovation & Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment, Engineering Research Center of Landscape Environment of Ministry of Education, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education, School of Landscape Architecture, Beijing Forestry University, Beijing, 100083 China.

is the only plant in the genus of the Rosaceae family with a characteristic floral scent, and the main component of this scent is benzyl acetate. By contrast, benzyl acetate is not synthesized in flowers. Here, we searched for () genes based on genomic data from and and found 44 unique in . Read More

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http://www.nature.com/articles/s41438-018-0104-4
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http://dx.doi.org/10.1038/s41438-018-0104-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355818PMC
February 2019
1 Read

Genome-wide analysis of the NAC transcription factor family in Tartary buckwheat (Fagopyrum tataricum).

BMC Genomics 2019 Feb 6;20(1):113. Epub 2019 Feb 6.

College of Life Science, Sichuan Agricultural University, Ya'an, China.

Background: The NAC (NAM, ATAF1/2, and CUC2) transcription factor family represents a group of large plant-specific transcriptional regulators, participating in plant development and response to external stress. However, there is no comprehensive study on the NAC genes of Tartary buckwheat (Fagopyrum tataricum), a large group of extensively cultivated medicinal and edible plants. The recently published Tartary buckwheat genome permits us to explore all the FtNAC genes on a genome-wide basis. Read More

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http://dx.doi.org/10.1186/s12864-019-5500-0DOI Listing
February 2019

Comparative 3D genome organization in apicomplexan parasites.

Proc Natl Acad Sci U S A 2019 Feb 5. Epub 2019 Feb 5.

Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521;

The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression. In the human malaria parasite , the clustering of a family of virulence genes correlates with their coordinated silencing and has a strong influence on the overall organization of the genome. To identify conserved and species-specific principles of genome organization, we performed Hi-C experiments and generated 3D genome models for five species and two related apicomplexan parasites. Read More

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http://dx.doi.org/10.1073/pnas.1810815116DOI Listing
February 2019
7 Reads

Shared ancient sex chromosomes in varanids, beaded lizards and alligator lizards.

Mol Biol Evol 2019 Feb 5. Epub 2019 Feb 5.

Department of Ecology, Faculty of Science, Charles University, Vinicná 7, 128 44, Prague, Czech Republic.

Sex determination in varanids, Gila monsters, beaded lizards and other anguimorphan lizards is still poorly understood. Sex chromosomes were reported only in a few species based solely on cytogenetics, which precluded assessment of their homology. We uncovered Z-chromosome specific genes in varanids from their transcriptomes. Read More

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http://dx.doi.org/10.1093/molbev/msz024DOI Listing
February 2019

Drought stress affects the protein and dietary fiber content of wholemeal wheat flour in wheat/Aegilops addition lines.

PLoS One 2019 5;14(2):e0211892. Epub 2019 Feb 5.

Department of Plant Science, Rothamsted Research, Harpenden, United Kingdom.

Wild relatives of wheat, such as Aegilops spp. are potential sources of genes conferring tolerance to drought stress. As drought stress affects seed composition, the main goal of the present study was to determine the effects of drought stress on the content and composition of the grain storage protein (gliadin (Gli), glutenin (Glu), unextractable polymeric proteins (UPP%) and dietary fiber (arabinoxylan, β-glucan) components of hexaploid bread wheat (T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211892PLOS
February 2019

The Hologenome Concept of Evolution: Medical Implications.

Rambam Maimonides Med J 2019 Jan 28;10(1). Epub 2019 Jan 28.

Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel.

All natural animals and plants are holobionts, consisting of the host and microbiome, which is composed of abundant and diverse microorganisms. Health and disease of holobionts depend as much on interactions between host and microbiome and within the microbiome, as on interactions between organs and body parts of the host. Recent evidence indicates that a significant fraction of the microbiome is transferred by a variety of mechanisms from parent to offspring for many generations. Read More

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http://dx.doi.org/10.5041/RMMJ.10359DOI Listing
January 2019
2 Reads

Maternal regulation of chromosomal imprinting in animals.

Chromosoma 2019 Feb 5. Epub 2019 Feb 5.

Epigenetics Laboratory, Department of Natural Sciences, Novosibirsk State University, Pirogov str. 2, Novosibirsk, 630090, Russian Federation.

Chromosomal imprinting requires an epigenetic system that "imprints" one of the two parental chromosomes such that it results in a heritable (cell-to-cell) change in behavior of the "imprinted" chromosome. Imprinting takes place when the parental genomes are separate, which occurs during gamete formation in the respective germ-lines and post-fertilization during the period when the parental pro-nuclei lie separately within the ooplasm of the zygote. In the mouse, chromosomal imprinting is regulated by germ-line specific DNA methylation. Read More

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http://dx.doi.org/10.1007/s00412-018-00690-5DOI Listing
February 2019
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Cyclin D1 integrates G9a-mediated histone methylation.

Oncogene 2019 Feb 4. Epub 2019 Feb 4.

Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, 3805 Old Easton Rd., Doylestown, PA, 18902, USA.

Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. Read More

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http://dx.doi.org/10.1038/s41388-019-0723-8DOI Listing
February 2019
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Exploring the genetics of trotting racing ability in horses using a unique Nordic horse model.

BMC Genomics 2019 Feb 4;20(1):104. Epub 2019 Feb 4.

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: Horses have been strongly selected for speed, strength, and endurance-exercise traits since the onset of domestication. As a result, highly specialized horse breeds have developed with many modern horse breeds often representing closed populations with high phenotypic and genetic uniformity. However, a great deal of variation still exists between breeds, making the horse particularly well suited for genetic studies of athleticism. Read More

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http://dx.doi.org/10.1186/s12864-019-5484-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360714PMC
February 2019

Pipeline for the Rapid Development of Cytogenetic Markers Using Genomic Data of Related Species.

Genes (Basel) 2019 Feb 1;10(2). Epub 2019 Feb 1.

Laboratory of Applied Genomics and Crop Breeding, All-Russia Research Institute of Agricultural Biotechnology, Timiryazevskaya str. 42, Moscow 127550, Russia.

Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping using fluorescence in situ hybridization (FISH). The recent progress in the development of whole-genome sequencing and bioinformatics tools enables rapid and cost-effective searches for TRs including satDNA that can be converted into molecular cytogenetic markers. Read More

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http://dx.doi.org/10.3390/genes10020113DOI Listing
February 2019

Automated Nuclear Cartography Reveals Conserved Sperm Chromosome Territory Localization across 2 Million Years of Mouse Evolution.

Genes (Basel) 2019 Feb 1;10(2). Epub 2019 Feb 1.

School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.

Measurements of nuclear organization in asymmetric nuclei in 2D images have traditionally been manual. This is exemplified by attempts to measure chromosome position in sperm samples, typically by dividing the nucleus into zones, and manually scoring which zone a fluorescence in-situ hybridisation (FISH) signal lies in. This is time consuming, limiting the number of nuclei that can be analyzed, and prone to subjectivity. Read More

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http://dx.doi.org/10.3390/genes10020109DOI Listing
February 2019

Genome-wide association mapping of grain yield in a diverse collection of spring wheat (Triticum aestivum L.) evaluated in southern Australia.

PLoS One 2019 4;14(2):e0211730. Epub 2019 Feb 4.

Australian Centre for Plant Functional Genomics and School of Agriculture, Food and Wine, Waite Research Institute, The University of Adelaide, Glen Osmond, SA, Australia.

Wheat landraces, wild relatives and other 'exotic' accessions are important sources of new favorable alleles. The use of those exotic alleles is facilitated by having access to information on the association of specific genomic regions with desirable traits. Here, we conducted a genome-wide association study (GWAS) using a wheat panel that includes landraces, synthetic hexaploids and other exotic wheat accessions to identify loci that contribute to increases in grain yield in southern Australia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211730PLOS
February 2019

Genome sequence of the barred knifejaw Oplegnathus fasciatus (Temminck & Schlegel, 1844): the first chromosome-level draft genome in the family Oplegnathidae.

Gigascience 2019 Feb 1. Epub 2019 Feb 1.

Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao, 266071, China.

Background: The barred knifejaw (Oplegnathus fasciatus), a member of the Oplegnathidae family of the Centrarchiformes, is a commercially important rocky reef fish native to East Asia. O. fasciatus has become an important fishery resource for offshore cage aquaculture and fish stocking of marine ranching in China, Japan and Korea. Read More

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http://dx.doi.org/10.1093/gigascience/giz013DOI Listing
February 2019

Genome-wide identification and characterization of Hsp70 gene family in Nicotiana tabacum.

Mol Biol Rep 2019 Feb 1. Epub 2019 Feb 1.

Key Laboratory for Cultivation of Tobacco Industry, College of Tobacco Science, Henan Agricultural University, Zhengzhou, China.

Heat shock proteins 70 (Hsp70) constitute a highly conserved protein family of cellular chaperones widely distributed in plants, where they play a fundamental role in response to biotic and abiotic stress. Until now, genome-wide analyses of the Hsp70 gene family have been conducted for some species. However, reports about Hsp70 genes in Nicotiana tabacum are scarce. Read More

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http://dx.doi.org/10.1007/s11033-019-04644-7DOI Listing
February 2019
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Acute leukemias harboring KMT2A/MLLT10 fusion: a 10-year experience from a single genomics laboratory.

Genes Chromosomes Cancer 2019 Feb 1. Epub 2019 Feb 1.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The MLLT10 (formerly AF10) gene is the fourth most common KMT2A fusion partner across all acute leukemias and requires at least three breaks to form an in-frame KMT2A/MLLT10 fusion due to the opposite orientation of each gene. A 10-year retrospective review was performed to identify individuals from all age groups that harbor KMT2A/MLLT10 fusion obtained by our KMT2A/MLLT10 dual-color dual-fusion fluorescence in situ hybridization (D-FISH) assay. Of the 60 unique individuals identified, 31 were male and 29 were female (M:F ratio, 1. Read More

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http://dx.doi.org/10.1002/gcc.22741DOI Listing
February 2019

Pediatric acute myeloid leukemia with t(7;21)(p22;q22).

Genes Chromosomes Cancer 2019 Jan 31. Epub 2019 Jan 31.

Department of Pathology, University of Utah, Salt Lake City, Utah.

The t(7;21)(p22;q22) resulting in RUNX1-USP42 fusion, is a rare but recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML) and myelodysplastic syndromes. The prognostic significance of this translocation has not been well established due to the limited number of patients. Herein, we report three pediatric AML patients with t(7;21)(p22;q22). Read More

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http://doi.wiley.com/10.1002/gcc.22740
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http://dx.doi.org/10.1002/gcc.22740DOI Listing
January 2019
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Construction of a high density genetic map of an interspecific cross of Capsicum chinense and Capsicum annuum and QTL analysis of floral traits.

Sci Rep 2019 Jan 31;9(1):1054. Epub 2019 Jan 31.

Key Laboratory of Horticultural Crop Biology and Germplasm innovation in South China, College of Horticulture, South China Agricultural University, Guangzhou, 510642, China.

The yield of pepper plants (Capsicum spp.) is their most important trait and is affected by the flower number and flowering time. Capsicum annuum produces a single flower per node and has an early flowering habit. Read More

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http://www.nature.com/articles/s41598-018-38370-0
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http://dx.doi.org/10.1038/s41598-018-38370-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355862PMC
January 2019
7 Reads

Maize Dek15 Encodes the Cohesin-loading Complex Subunit SCC4 and is Essential for Chromosome Segregation and Kernel Development.

Plant Cell 2019 Jan 31. Epub 2019 Jan 31.

China Agricultural University CITY: Beijing POSTAL_CODE: 100193 China [CN]

Cohesin complexes maintain sister chromatid cohesion to ensure proper chromosome segregation during mitosis and meiosis. In plants, the exact components and functions of the cohesin complex remain poorly understood. Here, we positionally cloned the classic maize (Zea mays) mutant defective kernel 15 (dek15), revealing that it encodes a homolog of SISTER CHROMATID COHESION PROTEIN 4 (SCC4), a loader subunit of the cohesin ring. Read More

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http://dx.doi.org/10.1105/tpc.18.00921DOI Listing
January 2019
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Using genomic data to study insecticide resistance in the house fly, Musca domestica.

Pestic Biochem Physiol 2018 Oct 12;151:76-81. Epub 2018 Jan 12.

Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY, USA. Electronic address:

The house fly, Musca domestica, is a major pest at livestock facilities throughout the world. Insecticides have been the most common control strategy for flies, but many populations have evolved resistance. The speed by which we are able to identify the mutations responsible for resistance has been a major challenge for the development of high throughput resistance monitoring assays as new insecticides are introduced for control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00483575173058
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http://dx.doi.org/10.1016/j.pestbp.2018.01.001DOI Listing
October 2018
4 Reads