66 results match your criteria Genes Brain and Behavior [Journal]


No association between polymorphisms in the promoter region of dopamine receptor D2 gene and schizophrenia in the northern Chinese Han population: A case-control study.

Brain Behav 2019 Feb 18;9(2):e01193. Epub 2019 Jan 18.

School of Forensic Medicine, China Medical University, Shenyang, China.

Background: Epidemiological studies found that genetic factors are among the causes of schizophrenia, exclusively the genes involved in the dopamine system. Prior to this, the role of dopamine receptor D2 (DRD2) gene promoter polymorphisms and schizophrenia has been studied extensively, but there are still some uncertainties about these associations. The present study is focusing on the association between the DRD2 gene promoter region polymorphisms and schizophrenia in the northern Chinese Han population. Read More

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http://doi.wiley.com/10.1002/brb3.1193
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http://dx.doi.org/10.1002/brb3.1193DOI Listing
February 2019
5 Reads

Association between miRNAs expression and cognitive performances of Pediatric Multiple Sclerosis patients: A pilot study.

Brain Behav 2019 Feb 17;9(2):e01199. Epub 2019 Jan 17.

Department of Basic Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy.

Introduction: The Pediatric onset of Multiple Sclerosis (PedMS) occurs in up to 10% of all cases. Cognitive impairment is one of the frequent symptoms, exerting severe impact in patients' quality of life and school performances. The underlying pathogenic mechanisms are not fully understood, and molecular markers predictive of cognitive dysfunctions need to be identified. Read More

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http://doi.wiley.com/10.1002/brb3.1199
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http://dx.doi.org/10.1002/brb3.1199DOI Listing
February 2019
4 Reads

Dysmorphic contribution of neurotransmitter and neuroendocrine system polymorphisms to subtherapeutic mood states.

Brain Behav 2019 Feb 17;9(2):e01140. Epub 2019 Jan 17.

Department of Surgery, Biochemistry and Immunology, School of Medicine, University of Malaga, Malaga, Spain.

Objective: From an evolutionary perspective, emotions emerged as rapid adaptive reactions that increase survival rates. Current psychobiology includes the consideration that genetic changes affecting neuroendocrine and neurotransmission pathways may also be affecting mood states. Following this hypothesis, abnormal levels of any of the aminergic neurotransmitters would be of considerable importance in the development of a pathophysiological state. Read More

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http://dx.doi.org/10.1002/brb3.1140DOI Listing
February 2019
1 Read

Gene mutations in a Han Chinese Alzheimer's disease cohort.

Brain Behav 2019 Jan 14;9(1):e01180. Epub 2018 Dec 14.

Department of Neurology, Xinxiang Medical University, Xinxiang, China.

Objective: Alzheimer's disease (AD) is the most common form of dementia characterized by memory loss at disease onset. The gene mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the frequent causes of AD. However, the clinical and genetic features of AD overlap with other neurodegenerative diseases. Read More

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http://dx.doi.org/10.1002/brb3.1180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346667PMC
January 2019
14 Reads

Sex-biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus) and potential behavioral correlates.

Brain Behav 2018 Dec 30;8(12):e01148. Epub 2018 Oct 30.

Brain Institute and Health Sciences Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil.

Introduction: The common marmoset (Callithrix jacchus), a small New World monkey, has been widely used as a biological model in neuroscience to elucidate neural circuits involved in cognition and to understand brain dysfunction in neuropsychiatric disorders. In this regard, the availability of gene expression data derived from next-generation sequencing (NGS) technologies represents an opportunity for a molecular contextualization. Sexual dimorphism account for differences in diseases prevalence and prognosis. Read More

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http://dx.doi.org/10.1002/brb3.1148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305938PMC
December 2018
2 Reads

16p11.2 deletion in patients with paroxysmal kinesigenic dyskinesia but without intellectual disability.

Brain Behav 2018 Nov 11;8(11):e01134. Epub 2018 Oct 11.

Institute of Neuroscience, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Introduction: Mutations of the PRRT2 gene are the most common cause for paroxysmal kinesigenic dyskinesia. However, patients with negative PRRT2 mutations are not rare. The aim of this study is to determine whether copy number variant of PRRT2 gene is another potential pathogenic mechanism in the patients with paroxysmal kinesigenic dyskinesia with negative PRRT2 point and frameshift mutations. Read More

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http://doi.wiley.com/10.1002/brb3.1134
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http://dx.doi.org/10.1002/brb3.1134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236233PMC
November 2018
5 Reads

Quantitative proteomic analysis of intracerebral hemorrhage in rats with a focus on brain energy metabolism.

Brain Behav 2018 Nov 11;8(11):e01130. Epub 2018 Oct 11.

Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, China.

Introduction: Intracerebral hemorrhage (ICH) is a lethal cerebrovascular disorder with a high mortality and morbidity. The pathophysiological mechanisms underlying ICH-induced secondary injury remain unclear.

Methods: To examine one of the gaps in the knowledge about ICH pathological mechanisms, isobaric tag for relative and absolute quantification (iTRAQ)-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used in collagenase-induced ICH rats on the 2nd day. Read More

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http://doi.wiley.com/10.1002/brb3.1130
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http://dx.doi.org/10.1002/brb3.1130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236229PMC
November 2018
3 Reads
1 Citation

Systematic analysis of genetic variants in patients with essential tremor.

Brain Behav 2018 Oct 5;8(10):e01100. Epub 2018 Sep 5.

Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.

Background: Essential tremor (ET), a prevalent neurological disorder, is featured by postural and kinetic tremors in upper limbs. Studies of twins and families indicate an important role for genetic factors in ET development. There are substantial overlaps between ET and Parkinson's disease (PD). Read More

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http://dx.doi.org/10.1002/brb3.1100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192404PMC
October 2018
2 Reads

Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses.

Brain Behav 2018 Sep 23;8(9):e01096. Epub 2018 Aug 23.

Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln, New Zealand.

Introduction: The neuronal ceroid lipofuscinoses (NCLs; Batten disease) are a group of fatal neurodegenerative lysosomal storage diseases of children caused by various mutations in a range of genes. Forms associated with mutations in two of these, CLN5 and CLN6, are being investigated in well-established sheep models. Brain atrophy leading to psychomotor degeneration is among the defining features, as is regional progressive ossification of the inner cranium. Read More

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http://dx.doi.org/10.1002/brb3.1096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160654PMC
September 2018
14 Reads

miRNA-regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol.

Brain Behav 2018 06 30;8(6):e00989. Epub 2018 Apr 30.

Department of Biostatistics and Informatics, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.

Introduction: Studying innate sensitivity to ethanol can be an important first step toward understanding alcohol use disorders. In brain, we investigated transcripts, with evidence of miRNA modulation related to a predisposition to the hypnotic effect of ethanol, as measured by loss of righting reflex (LORR).

Methods: Expression of miRNAs (12 samples) and expression of mRNAs (353 samples) in brain were independently analyzed for an association with LORR in mice from the LXS recombinant inbred panel gathered across several small studies. Read More

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http://dx.doi.org/10.1002/brb3.989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991579PMC
June 2018
9 Reads

Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.

Brain Behav 2018 Aug 11;8(8):e01017. Epub 2018 Jul 11.

Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.

Introduction: Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake.

Methods: An adult population within the Methyl Epigenome Network Association project was included (n = 473). Read More

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http://dx.doi.org/10.1002/brb3.1017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085894PMC
August 2018
15 Reads

Autism throughout genetics: Perusal of the implication of ion channels.

Brain Behav 2018 Aug 22;8(8):e00978. Epub 2018 Jun 22.

L'institut du Thorax, INSERM UMR1087/CNRS UMR6291, Université de Nantes, Nantes, France.

Background: Autism spectrum disorder (ASD) comprises a group of neurodevelopmental psychiatric disorders characterized by deficits in social interactions, interpersonal communication, repetitive and stereotyped behaviors and may be associated with intellectual disabilities. The description of ASD as a synaptopathology highlights the importance of the synapse and the implication of ion channels in the etiology of these disorders.

Methods: A narrative and critical review of the relevant papers from 1982 to 2017 known by the authors was conducted. Read More

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http://dx.doi.org/10.1002/brb3.978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085908PMC
August 2018
1 Read

Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease.

Brain Behav 2018 Jul 1;8(7):e01008. Epub 2018 Jun 1.

Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Dopamine therapy in Parkinson disease (PD) can have differential effects on inhibitory action control, or the ability to inhibit reflexive or impulsive actions. Dopamine agonist (DAAg) medications, which preferentially target D2 and D3 receptors, can either improve or worsen control of impulsive actions in patients with PD. We have reported that the direction of this effect depends on baseline levels of performance on inhibitory control tasks. Read More

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http://doi.wiley.com/10.1002/brb3.1008
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http://dx.doi.org/10.1002/brb3.1008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043698PMC
July 2018
13 Reads

Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study.

Brain Behav 2018 06 22;8(6):e01001. Epub 2018 May 22.

Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Zografou, Athens, Greece.

Background: The widespread use of wireless devices during the last decades is raising concerns about adverse health effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted from these devices. Recent research is focusing on unraveling the underlying mechanisms of RF-EMR and potential cellular targets. The "omics" high-throughput approaches are powerful tools to investigate the global effects of RF-EMR on cellular physiology. Read More

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http://dx.doi.org/10.1002/brb3.1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991598PMC
June 2018
12 Reads

Novel compound heterozygous mutations in the gene identified in a Chinese pedigree with early-onset Parkinson's disease.

Brain Behav 2018 01 19;8(1):e00901. Epub 2017 Dec 19.

Department of Neurology Henan Provincial People's Hospital Zhengzhou China.

Objects: To capture point mutations and short insertions/deletions in 49 previously reported genes associated with Parkinson's disease (PD) in a Chinese pedigree with early-onset Parkinson's disease (EOPD)-affected individuals.

Methods: Clinical examinations and genomic analysis were performed on 21 subjects belonging to three generations of a Chinese family. Target region capture and high-throughput sequencing were used for screening 49 genes, which were previously reported to be associated with PD. Read More

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http://dx.doi.org/10.1002/brb3.901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853629PMC
January 2018
8 Reads

Maternal separation affects expression of stress response genes and increases vulnerability to ethanol consumption.

Brain Behav 2018 01 30;8(1):e00841. Epub 2017 Nov 30.

Laboratório de Genética Animal e Humana Departamento de Biologia Geral Universidade Federal de Minas Gerais Belo Horizonte MG Brazil.

Introduction: Maternal separation is an early life stress event associated with behavioral alterations and ethanol consumption. We aimed to expand the current understanding on the molecular mechanisms mediating the impact of postnatal stress on ethanol consumption.

Methods: In the first experiment (T1), some of the pups were separated from their mothers for 6 hr daily (Maternal Separation group - MS), whereas the other pups remained in the cage with their respective mothers (Control group - C). Read More

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http://dx.doi.org/10.1002/brb3.841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853632PMC
January 2018
5 Reads

DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.

Brain Behav 2018 02 23;8(2):e00914. Epub 2018 Jan 23.

Peking University Sixth Hospital (Institute of Mental Health) National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing China.

Objective: To explore the association of DLGAP1 gene with executive function (EF) in attention deficit hyperactivity disorder (ADHD) children.

Method: A total of 763 ADHD children and 140 healthy controls were enrolled. The difference of EF between ADHD and controls was analyzed using the analysis of covariance (ANCOVA), with IQ, sex, and age as covariates. Read More

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http://dx.doi.org/10.1002/brb3.914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822579PMC
February 2018
10 Reads

Poststroke emotional disturbances and a tryptophan hydroxylase 2 gene polymorphism.

Brain Behav 2018 02 11;8(2):e00892. Epub 2018 Jan 11.

University of Ulsan Asan Medical Center Seoul South Korea.

Objectives: Emotional dysfunction is a common finding in stroke patients. Despite reports on serotonergic involvement in the etiology of poststroke emotional dysfunction (PSED), the role of serotonin synthesizing tryptophan hydroxylase 2 (TPH2) genes in the development of PSED remains unclear.

Methods: Genotyping of rs4641528 and rs10879355 was performed from genomic DNA of 383 stroke patients collected previously and stored at -70°C. Read More

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http://dx.doi.org/10.1002/brb3.892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822583PMC
February 2018
7 Reads

Individual differences in EEG correlates of recognition memory due to DAT polymorphisms.

Brain Behav 2017 12 10;7(12):e00870. Epub 2017 Nov 10.

Psychology Department University of New Hampshire Durham NH USA.

Introduction: Although previous research suggests that genetic variation in dopaminergic genes may affect recognition memory, the role dopamine transporter expression may have on the behavioral and EEG correlates of recognition memory has not been well established.

Objectives: The study aims to reveal how individual differences in dopaminergic functioning due to genetic variations in the dopamine transporter gene influences behavioral and EEG correlates of recognition memory.

Methods: Fifty-eight participants performed an item recognition task. Read More

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http://dx.doi.org/10.1002/brb3.870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745248PMC
December 2017
5 Reads

and are putative modulators of dyslexia-related MMR.

Brain Behav 2017 11 18;7(11):e00851. Epub 2017 Oct 18.

Fraunhofer Institute for Cell Therapy and Immunology Leipzig Germany.

Background: Dyslexia is a specific learning disorder affecting reading and spelling abilities. Its prevalence is ~5% in German-speaking individuals. Although the etiology of dyslexia largely remains to be determined, comprehensive evidence supports deficient phonological processing as a major contributing factor. Read More

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http://dx.doi.org/10.1002/brb3.851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698869PMC
November 2017
4 Reads

Investigation of the Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Brain Behav 2017 11 6;7(11):e00850. Epub 2017 Oct 6.

Department of Psychiatry University of Alberta Edmonton AB Canada.

Objective: rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.

Methods: One hundred and sixty-nine subjects with psychosis were recruited. Read More

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http://doi.wiley.com/10.1002/brb3.850
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http://dx.doi.org/10.1002/brb3.850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698868PMC
November 2017
26 Reads

Effects of deficiency on emotional-like behaviors in mice under chronic immobilization stress.

Brain Behav 2017 10 23;7(10):e00831. Epub 2017 Sep 23.

College of Medicine & Forensics Key Laboratory of the Health Ministry for Forensic Medicine Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry Xi'an Jiaotong University Health Science Center Xi'an China.

Background: Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender-specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain-derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss. Read More

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http://dx.doi.org/10.1002/brb3.831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651401PMC
October 2017
15 Reads

Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain.

Brain Behav 2017 10 6;7(10):e00780. Epub 2017 Sep 6.

Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS.

Introduction: Diet and activity are recognized as modulators of nervous system disease, including pain. Studies of exercise consistently reveal a benefit on pain. This study focused on female rats to understand differences related to metabolic status and peripheral nerve function in females. Read More

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http://dx.doi.org/10.1002/brb3.780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651381PMC
October 2017
18 Reads

ε genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.

Brain Behav 2017 09 9;7(9):e00791. Epub 2017 Aug 9.

Department of Neurological Surgery University of California, San Francisco San Francisco CA USA.

Introduction: The apolipoprotein E () ε allele associates with memory impairment in neurodegenerative diseases. Its association with memory after mild traumatic brain injury (mTBI) is unclear.

Methods: mTBI patients (Glasgow Coma Scale score 13-15, no neurosurgical intervention, extracranial Abbreviated Injury Scale score ≤1) aged ≥18 years with genotyping results were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study. Read More

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http://dx.doi.org/10.1002/brb3.791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607554PMC
September 2017
32 Reads

Sex-specific effects of Val158Met polymorphism on corpus callosum structure: A whole-brain diffusion-weighted imaging study.

Brain Behav 2017 09 9;7(9):e00786. Epub 2017 Aug 9.

Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.

Background: Genetic polymorphisms play a significant role in determining brain morphology, including white matter structure and may thus influence the development of brain functions. The main objective of this study was to examine the effect of Val158Met (rs4680) polymorphism of Catechol--Methyltransferase () gene on white matter connectivity in healthy adults.

Methods: We used a whole-brain diffusion-weighted imaging method with Tract-Based Spatial Statistics (TBSS) analysis to examine white matter structural integrity in intrinsic brain networks on a sample of healthy subjects ( = 82). Read More

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http://dx.doi.org/10.1002/brb3.786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607550PMC
September 2017
15 Reads

Interaction effects of and gene variants on continuous performance test variables in patients with ADHD.

Brain Behav 2017 09 1;7(9):e00785. Epub 2017 Aug 1.

Division of Child and Adolescent Psychiatry Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea.

Introduction: The G protein-coupled receptor kinase interacting protein 1 gene () has been proposed to be a risk gene for attention deficit hyperactivity disorder (ADHD), and it regulates the endocytosis of G protein-coupled receptors like dopamine receptors. The purpose of this study was to investigate the interaction effects of and dopamine receptor D4 () gene variants on variables of the continuous performance test (CPT).

Methods: This study recruited 255 ADHD patients and 98 healthy controls (HC) who underwent CPT and genetic analyses. Read More

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http://dx.doi.org/10.1002/brb3.785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607549PMC
September 2017
13 Reads

Influence of and genetic variability on personality dimensions in anorexia and bulimia nervosa.

Brain Behav 2017 09 27;7(9):e00784. Epub 2017 Jul 27.

Department of Medical & Surgical Therapeutics Division of Pharmacology Medical School University of Extremadura Badajoz Spain.

Introduction: and are obesity-related genes that interact to regulate feeding behavior. We hypothesize that variability in these loci, isolated or in combination, could also be related to the risk of eating disorders (ED) and/or associated psychological traits.

Methods: We screened 425 participants (169 ED patients, 75 obese subjects, and 181 controls) for 10 clinically relevant and tag single-nucleotide polymorphisms (SNPs) in and by the Sequenom MassARRAY platform and direct sequencing. Read More

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http://dx.doi.org/10.1002/brb3.784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607548PMC
September 2017
11 Reads

Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice.

Brain Behav 2017 08 22;7(8):e00767. Epub 2017 Jul 22.

Institute of Health and Medical Innovation Translational Research Institute Queensland University of Technology Woolloongabba QLD Australia.

Background: Factors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment. While we cannot control the genes we inherit, we can modify our environment. Understanding the role that social and environmental experiences play in alcohol and sucrose consumption is critical for developing preventative interventions and treatments for alcohol use disorders and obesity. Read More

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http://dx.doi.org/10.1002/brb3.767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561324PMC
August 2017
4 Reads

The effect of and polymorphisms on executive function and the impact of early life stress.

Brain Behav 2017 05 12;7(5):e00695. Epub 2017 Apr 12.

School of Psychology University of Lincoln Lincoln UK.

Introduction: Previous research has indicated that variation in genes encoding catechol-O-methyltransferase () and dopamine receptor D2 () may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of and polymorphisms on executive function and the impact of early life stress in healthy adults. Read More

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http://dx.doi.org/10.1002/brb3.695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434197PMC
May 2017
29 Reads

Parental brain-derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents' warmth.

Brain Behav 2017 05 4;7(5):e00685. Epub 2017 Apr 4.

Department of Psychology The Hebrew University of Jerusalem Jerusalem Israel.

Background: Parental warmth has been associated with various child behaviors, from effortful control to callous-unemotional traits. Factors that have been shown to affect parental warmth include heritability and child behavior. However, there is limited knowledge about which specific genes are involved, how they interact with child behavior, how they affect differential parenting, and how they affect fathers. Read More

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http://dx.doi.org/10.1002/brb3.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434190PMC
May 2017
12 Reads

Olfaction in carriers in Chinese patients with Parkinson disease.

Brain Behav 2017 05 28;7(5):e00680. Epub 2017 Mar 28.

Department and Institute of Neurology Huashan Hospital Fudan University Shanghai China.

Background: Olfactory identification was reported to be better among PD (Parkinson disease) patients with mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of mutations patients was better in Chinese population was still unknown.

Objective: To assess olfaction function among PD patients with mutations in Chinese population.

Materials And Methods: A total of 226 PD patients with a positive family history or an early-onset age (<50 years) were enrolled for genetic testing of PD related genes by target sequencing and multiple ligation-dependent probe amplification. Read More

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http://dx.doi.org/10.1002/brb3.680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434185PMC
May 2017
23 Reads

Reading LINEs within the cocaine addicted brain.

Brain Behav 2017 05 6;7(5):e00678. Epub 2017 Apr 6.

Department of Psychiatry Center for Neurobiology and Behavior University of Pennsylvania Perelman School of Medicine Philadelphia PA USA.

Introduction: Long interspersed element (LINE)-1 (L1) is a type of retrotransposon capable of mobilizing into new genomic locations. Often studied in Mendelian diseases or cancer, L1s may also cause somatic mutation in the developing central nervous system. Recent reports showed L1 transcription was activated in brains of cocaine-treated mice, and L1 retrotransposition was increased in cocaine-treated neuronal cell cultures. Read More

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http://dx.doi.org/10.1002/brb3.678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434184PMC
May 2017
29 Reads

High-throughput sequencing revealed a novel SETX mutation in a Hungarian patient with amyotrophic lateral sclerosis.

Brain Behav 2017 04 15;7(4):e00669. Epub 2017 Mar 15.

Department of Medical Genetics University of Szeged Szeged Hungary.

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of the motor neurons. To date, 126 genes have been implicated in ALS. Therefore, the heterogenous genetic background of ALS requires comprehensive genetic investigative approaches. Read More

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http://dx.doi.org/10.1002/brb3.669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390843PMC
April 2017
18 Reads

Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.

Brain Behav 2017 04 15;7(4):e00651. Epub 2017 Mar 15.

Department of Psychiatry Washington University School of Medicine St. Louis MO USA.

Background: Smoking is a leading cause of preventable death. Early studies based on samples of twins have linked the lifetime smoking practices to genetic predisposition. The flavin-containing monooxygenase (FMO) protein family consists of a group of enzymes that metabolize drugs and xenobiotics. Read More

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http://dx.doi.org/10.1002/brb3.651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390834PMC
April 2017
31 Reads

The role of genes, intelligence, personality, and social engagement in cognitive performance in Klinefelter syndrome.

Brain Behav 2017 03 9;7(3):e00645. Epub 2017 Feb 9.

Department of Endocrinology and Internal Medicine (MEA) Aarhus University Hospital Aarhus Denmark; Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark.

Introduction: The determinants of cognitive deficits among individuals with Klinefelter syndrome (KS) are not well understood. This study was conducted to assess the impact of general intelligence, personality, and social engagement on cognitive performance among patients with KS and a group of controls matched for age and years of education.

Methods: Sixty-nine patients with KS and 69 controls were assessed in terms of IQ, NEO personality inventory, the Autism Spectrum Quotient (AQ) scale, and measures of cognitive performance reflecting working memory and executive function. Read More

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http://doi.wiley.com/10.1002/brb3.645
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http://dx.doi.org/10.1002/brb3.645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346527PMC
March 2017
9 Reads

Reduced brain activation during inhibitory control in children with Val/Val genotype.

Brain Behav 2016 12 5;6(12):e00577. Epub 2016 Oct 5.

Department of Psychiatry University of Michigan Ann Arbor MI USA; Addiction Center University of Michigan Ann Arbor MI USA.

Introduction: Behavioral undercontrol is a well-established risk factor for substance use disorder, identifiable at an early age well before the onset of substance use. However, the biological mechanistic structure underlying the behavioral undercontrol/substance use relationship is not well understood. The enzyme catechol -methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex and striatum, brain regions involved in behavioral control. Read More

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http://dx.doi.org/10.1002/brb3.577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167006PMC
December 2016
5 Reads

Beyond main effects of gene-sets: harsh parenting moderates the association between a dopamine gene-set and child externalizing behavior.

Brain Behav 2016 08 31;6(8):e00498. Epub 2016 May 31.

Centre for Child and Family Studies Leiden University Leiden The Netherlands.

Background: In a longitudinal cohort study, we investigated the interplay of harsh parenting and genetic variation across a set of functionally related dopamine genes, in association with children's externalizing behavior. This is one of the first studies to employ gene-based and gene-set approaches in tests of Gene by Environment (G × E) effects on complex behavior. This approach can offer an important alternative or complement to candidate gene and genome-wide environmental interaction (GWEI) studies in the search for genetic variation underlying individual differences in behavior. Read More

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http://dx.doi.org/10.1002/brb3.498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980469PMC
August 2016
14 Reads

Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.

Brain Behav 2016 08 25;6(8):e00491. Epub 2016 May 25.

Department of Neurological Surgery Case Western Reserve University Cleveland Ohio 44106.

Introduction: The dopaminergic (DA) system plays important roles in addiction. However, human DA neurons from drug-dependent subjects were not available for study until recent development in inducible pluripotent stem cells (iPSCs) technology.

Methods: In this study, we produced DA neurons differentiated using iPSCs derived from opioid-dependent and control subjects carrying different 3' VNTR (variable number tandem repeat) polymorphism in the human dopamine transporter (DAT or SLC6A3). Read More

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http://dx.doi.org/10.1002/brb3.491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884574PMC
August 2016
11 Reads
1 Citation

Synergistic association of STX1A and VAMP2 with cryptogenic epilepsy in North Indian population.

Brain Behav 2016 07 14;6(7):e00490. Epub 2016 Jun 14.

Council of Scientific and Industrial Research (CSIR) Institute of Genomics and Integrative Biology (IGIB) Mall Road Delhi 110 007 India.

Introduction: "Common epilepsies", merely explored for genetics are the most frequent, nonfamilial, sporadic cases in hospitals. Because of their much debated molecular pathology, there is a need to focus on other neuronal pathways including the existing ion channels.

Methods: For this study, a total of 214 epilepsy cases of North Indian ethnicity comprising 59. Read More

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http://dx.doi.org/10.1002/brb3.490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951625PMC
July 2016
13 Reads

Epigenetic marks as the link between environment and development: examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene.

Brain Behav 2016 07 9;6(7):e00480. Epub 2016 Jun 9.

Department of Psychiatry University of California, San Francisco San Francisco California; Department of Psychiatry Kaiser-Permanente San Francisco Medical Center San Francisco California.

Background: Epigenetic processes act as a link between environment and individual development. This pilot study examined the association between socioeconomic status (SES), attachment, and methylation of the promoter region of the serotonin transporter gene (SLC6A4).

Methods: Attachment classification and SLC6A4 methylation was determined in 100 late adolescents. Read More

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http://doi.wiley.com/10.1002/brb3.480
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http://dx.doi.org/10.1002/brb3.480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951620PMC
July 2016
11 Reads

Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis.

Brain Behav 2016 07 3;6(7):e00472. Epub 2016 May 3.

Department of Pathology University of Veterinary Medicine Hannover Foundation Bünteweg 17 30559 Hannover Germany.

Introduction: CDV-DL (Canine distemper virus-induced demyelinating leukoencephalitis) represents a spontaneously occurring animal model for demyelinating disorders. Axonopathy represents a key pathomechanism in this disease; however, its underlying pathogenesis has not been addressed in detail so far. This study aimed at the characterization of axonal cytoskeletal, transport, and potential regenerative changes with a parallel focus upon Schwann cell remyelination. Read More

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http://doi.wiley.com/10.1002/brb3.472
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http://dx.doi.org/10.1002/brb3.472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864272PMC
July 2016
11 Reads

Genetic variation and cognitive dysfunction in opioid-treated patients with cancer.

Brain Behav 2016 07 3;6(7):e00471. Epub 2016 May 3.

Section of Palliative Medicine Department of Oncology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark; Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark.

Background And Purpose: The effects of single-nucleotide polymorphisms (SNPs) on the cognitive function of opioid-treated patients with cancer until now have not been explored, but they could potentially be related to poor functioning. This study aimed at identifying associations between SNPs of candidate genes, high opioid dose, and cognitive dysfunction.

Methods: Cross-sectional multicenter study (European Pharmacogenetic Opioid Study, 2005-2008); 1586 patients; 113 SNPs from 41 genes. Read More

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http://dx.doi.org/10.1002/brb3.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864175PMC
July 2016
18 Reads

Genome-wide time-to-event analysis on smoking progression stages in a family-based study.

Brain Behav 2016 05 22;6(5):e00462. Epub 2016 Apr 22.

Department of Public Health University of Helsinki Helsinki Finland; Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland.

Background: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date.

Methods: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages of smoking behavior by performing time-to-event analyses within a large Finnish twin family cohort (N = 1962), and further conducted mediation analyses of plausible intermediate traits for significant SNPs. Read More

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http://dx.doi.org/10.1002/brb3.462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842934PMC
May 2016
20 Reads
5 Citations

Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress.

Brain Behav 2016 01 17;6(1):e00392. Epub 2015 Dec 17.

Department of Physical Medicine and Rehabilitation Harvard Medical School Boston Massachusetts; Spaulding Rehabilitation Hospital Boston Massachusetts; Red Sox Foundation and Massachusetts General Hospital Home Base Program Boston Massachusetts; Defense and Veterans Brain Injury Center Bethesda Maryland; Center for Health and Rehabilitation Department of Physical Medicine & Rehabilitation Harvard Medical School 79/96 Thirteenth Street Charlestown Navy Yard Charlestown Massachusetts 02129.

Background: In addition to experiencing traumatic events while deployed in a combat environment, there are other factors that contribute to the development of posttraumatic stress disorder (PTSD) in military service members. This study explored the contribution of genetics, childhood environment, prior trauma, psychological, cognitive, and deployment factors to the development of traumatic stress following deployment.

Methods: Both pre- and postdeployment data on 231 of 458 soldiers were analyzed. Read More

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http://dx.doi.org/10.1002/brb3.392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834940PMC
January 2016
28 Reads

Possible relationship between common genetic variation and white matter development in a pilot study of preterm infants.

Brain Behav 2016 07 2;6(7):e00434. Epub 2016 Apr 2.

Centre for the Developing Brain King's College London St Thomas' Hospital London SE1 7EH UK.

Background: The consequences of preterm birth are a major public health concern with high rates of ensuing multisystem morbidity, and uncertain biological mechanisms. Common genetic variation may mediate vulnerability to the insult of prematurity and provide opportunities to predict and modify risk.

Objective: To gain novel biological and therapeutic insights from the integrated analysis of magnetic resonance imaging and genetic data, informed by prior knowledge. Read More

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http://dx.doi.org/10.1002/brb3.434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821839PMC
July 2016
19 Reads

Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.

Brain Behav 2016 04 15;6(4):e00446. Epub 2016 Mar 15.

Center for Genomics and Personalized Medicine Research Wake Forest School of Medicine Winston - Salem North Carolina.

Background: There is an established association between type 2 diabetes and accelerated cognitive decline. The exact mechanism linking type 2 diabetes and reduced cognitive function is less clear. The monoamine system, which is extensively involved in cognition, can be altered by type 2 diabetes status. Read More

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http://dx.doi.org/10.1002/brb3.446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797918PMC
April 2016
23 Reads

The ANKK1/DRD2 locus is a genomic substrate for affective priming and recognition of angry faces.

Brain Behav 2015 Nov 14;5(11):e00405. Epub 2015 Oct 14.

Faculty of Psychology Complutense University of Madrid Madrid Spain.

Introduction: Ankyrin repeat and kinase domain containing I (ANKK1) and dopamine D2 receptor (DRD2) genes have been associated with psychopathic traits in clinical samples. On the other hand, individuals high in psychopathy show reduced affective priming and deficits in facial expression recognition. We have hypothesized that these emotion-related cognitive phenomena are associated with Taq IA (rs18000497) SNP (single nucleotide polymorphism) of the ANKK1 gene and with C957T (rs6277) SNP of the DRD2 gene. Read More

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http://dx.doi.org/10.1002/brb3.405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667759PMC
November 2015
9 Reads

Polymorphisms in three genes are associated with hemorrhagic stroke.

Brain Behav 2015 Nov 1;5(11):e00395. Epub 2015 Oct 1.

Department of Research and Development Shanghai Benegene Biotechnology Co., Ltd. Shanghai 201114 China.

Background: Multiligand receptor for advanced glycation end products (RAGE), osteoprotegerin, and Golgb1 genes may be implicated in atherosclerosis and vascular diseases. Single nucleotide polymorphisms (SNPs) rs1035798 in RAGE gene, rs2073617 and rs2073618 in TNFRSF11B, and rs3732410 in Golgb1 will be investigated on whether there is an association with hemorrhagic stroke (HS) in Chinese population.

Methods: A total of 600 subjects including 199 HS patients and 401 controls were assayed. Read More

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http://dx.doi.org/10.1002/brb3.395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667756PMC
November 2015
7 Reads

Genetic association of the transcription of neuroplasticity-related genes and variation in stress-coping style.

Brain Behav 2015 Sep 24;5(9):e00360. Epub 2015 Jun 24.

Department of Neuropsychiatry, Oita University Faculty of Medicine Hasama-Machi, Yufu-Shi, Oita, 879-5593, Japan.

Introduction: Stress coping has been defined as the cognitive and behavioral efforts made to conquer, endure, or decrease external and internal demands and the conflicts between them. It has two main elements: the control or modification of the person-environment relationship causing the stress (i.e. Read More

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http://dx.doi.org/10.1002/brb3.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589807PMC
September 2015
13 Reads

Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons.

Brain Behav 2015 Aug 2;5(8):e00355. Epub 2015 Jun 2.

Department of Anesthesiology, Columbia University New York, New York, 10032 ; Department of Pharmacology, Columbia University New York, New York, 10032.

Background: Alcohol abuse and dependence are a serious public health problem. A large number of alcohol-regulated genes, (ARGs) are known to be influenced by alcohol use and withdrawal (AW), and recent evidence suggests that neuroadaptation to alcohol may be due in part to epigenetic changes in the expression of ARGs. Gabra4, which encodes the α4 subunit of GABAA receptors (GABAARs), is one of a number of ARGs that show remarkable plasticity in response to alcohol, being rapidly upregulated by acute alcohol exposure. Read More

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http://dx.doi.org/10.1002/brb3.355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559018PMC
August 2015
8 Reads