1,401,733 results match your criteria Genes & Development [Journal]


Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex.

Neuropsychopharmacol Rep 2019 Feb 16. Epub 2019 Feb 16.

Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Aims: The molecular and cellular mechanisms underlying the antidepressant effects of fluoxetine in the brain are not fully understood. Emerging evidence has led to the hypothesis that chronic fluoxetine treatment induces dematuration of certain types of mature neurons in rodents. These studies have focused on the properties of typical molecular and/or electrophysiological markers for neuronal maturation. Read More

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http://dx.doi.org/10.1002/npr2.12048DOI Listing
February 2019

The latest progress on miR-374 and its functional implications in physiological and pathological processes.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Non-coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non-coding RNAs (lncRNAs >200nt), stable non-coding RNAs (60-300nt), microRNAs (miRs or miRNAs, 18-24nt), circular RNAs, piwi-interacting RNAs (26-31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. Read More

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http://dx.doi.org/10.1111/jcmm.14219DOI Listing
February 2019

The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Infect Dis Ther 2019 Feb 16. Epub 2019 Feb 16.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.

Introduction: The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).

Methods: A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area hospitals was performed. Read More

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http://dx.doi.org/10.1007/s40121-019-0237-2DOI Listing
February 2019

miR-21 reverses impaired decidualization through modulation of KLF12 and NR4A1 expression in human endometrial stromal cells†.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Impaired decidualization has been considered a major cause of infertility in adenomyosis. However, the mechanism remains poorly understood. Recent studies suggest that micro RNAs (miR) play a crucial role in embryo implantation. Read More

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http://dx.doi.org/10.1093/biolre/ioz026DOI Listing
February 2019

Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics.

J Gerontol A Biol Sci Med Sci 2019 Feb 16. Epub 2019 Feb 16.

Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Germany.

Potential health benefits of blueberries may be due to vascular effects of anthocyanins which predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthocyanins and circulating metabolites play in mediating improvements in vascular function and explore potential mechanisms using metabolomics and nutrigenomics. Purified anthocyanins exerted a dose-dependent improvement of endothelial function in healthy humans, as measured by flow-mediated dilation (FMD). Read More

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http://dx.doi.org/10.1093/gerona/glz047DOI Listing
February 2019

Metabolic role of cGMP in S. cerevisiae: The murine phosphodiesterase-5 activity affects yeast cell proliferation by altering the cAMP/cGMP equilibrium.

FEMS Yeast Res 2019 Feb 17. Epub 2019 Feb 17.

Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Piazzale A. Moro 5 00185 Rome, Italy.

In higher eukaryotes cAMP and cGMP are signal molecules of major transduction pathways while phosphodiesterases (PDE) are a superfamily of cAMP/cGMP hydrolysing enzymes, modulatory components of these routes. Saccharomyces cerevisiae harbours two genes for PDE: Pde2 is a high affinity cAMP-hydrolysing enzyme, while Pde1 can hydrolyse both cAMP and cGMP. To gain insight into the metabolic role of cGMP in the physiology of yeast, the murine Pde5a1 gene encoding a specific cGMP-hydrolysing enzyme, was expressed in S. Read More

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http://dx.doi.org/10.1093/femsyr/foz016DOI Listing
February 2019

Impact of gene-specific germline pathogenic variants on presentation of endometrial cancer in Lynch syndrome.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Objective: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer.

Methods: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000277DOI Listing
February 2019

NFAT1 Hypermethylation Promotes Epithelial-Mesenchymal Transition and Metastasis in Nasopharyngeal Carcinoma by Activating ITGA6 Transcription.

Neoplasia 2019 Feb 14;21(3):311-321. Epub 2019 Feb 14.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China. Electronic address:

DNA methylation is an important epigenetic change in carcinogenesis. However, the function and mechanism of DNA methylation dysregulation in nasopharyngeal carcinoma (NPC) is still largely unclear. Our previous genome-wide microarray data showed that NFAT1 is one of the most hypermethylated transcription factor genes in NPC tissues. Read More

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http://dx.doi.org/10.1016/j.neo.2019.01.006DOI Listing
February 2019

Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.

J Nutr Biochem 2019 Jan 7;66:70-78. Epub 2019 Jan 7.

Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; NHC Key Laboratory on Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.. Electronic address:

Oxidative stress is considered an important pathogenic process of cardiac hypertrophy. Lycopene is a kind of carotenoid antioxidant that protects the cardiovascular system, so we hypothesized that lycopene might inhibit cardiac hypertrophy by attenuating oxidative stress. Phenylephrine and pressure overload were used to set up the hypertrophic models in vitro and in vivo respectively. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.002DOI Listing
January 2019

Therapeutic approaches to treat human spliceosomal diseases.

Curr Opin Biotechnol 2019 Feb 14;60:72-81. Epub 2019 Feb 14.

Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, United States.

Mutated RNA splicing machinery drives many human diseases and is a promising therapeutic target for engineering and small molecule therapy. In the case of mutations in individual genes that cause them to be incorrectly spliced, engineered splicing factors can be introduced to correct splicing of these aberrant transcripts and reduce the effects of the disease phenotype. Mutations that occur in certain splicing factor genes themselves have been implicated in many cancers, particularly myelodysplastic syndromes. Read More

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http://dx.doi.org/10.1016/j.copbio.2019.01.003DOI Listing
February 2019

Peripheral expression of long non-coding RNAs in bipolar patients.

J Affect Disord 2019 Feb 11;249:169-174. Epub 2019 Feb 11.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Long non-coding RNAs (lncRNAs) have established roles in the pathogenesis of diverse human disorders including neuropsychiatric disorders.

Methods: In the current study, we evaluated expression levels of six apoptosis-related lncRNAs (CCAT2, TUG1, PANDA, NEAT1, FAS-AS1 and OIP5-AS1) in the peripheral blood of bipolar disorder (BD) patients and healthy subjects to assess their contribution in the pathogenesis of BD.

Results: CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.034DOI Listing
February 2019

Whole-exome sequencing identifies variants associated with structural MRI markers in patients with bipolar disorders.

J Affect Disord 2019 Feb 11;249:159-168. Epub 2019 Feb 11.

Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea; Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Republic of Korea. Electronic address:

Background: Bipolar disorder (BD) is one of the most heritable psychiatric disorders. A growing number of whole-exome sequencing (WES) studies for BD has been performed, however, no research has examined the association between single nucleotide variants (SNVs) from WES and structural magnetic resonance imaging (MRI) data.

Methods: We sequenced whole-exomes in 53 patients with BD and 82 healthy control participants at an initial discovery stage and investigated the impacts of SNVs in risk genes from WES analysis on the cortical gray-matter thickness and integrity of white matter tracts and in the following stage. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.028DOI Listing
February 2019

Effects of gemfibrozil on sex hormones and reproduction related performances of Oryzias latipes following long-term (155 d) and short-term (21 d) exposure.

Ecotoxicol Environ Saf 2019 Feb 14;173:174-181. Epub 2019 Feb 14.

School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Gemfibrozil, a lipid-regulating pharmaceutical, has been widely used for treating dyslipidemia in humans and detected frequently in freshwater environments. Since plasma cholesterol is a precursor of steroid hormones, the use of gemfibrozil may influence the sex hormone balances. However, its endocrine toxicity following long-term exposure is not well understood. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.015DOI Listing
February 2019

Effect of sphingosine-1-phosphate on cryopreserved sheep testicular explants cultured in vitro.

Theriogenology 2019 Jan 31;128:184-192. Epub 2019 Jan 31.

Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, Front Royal, VA, USA.

Complete spermatogenesis has been achieved in vitro in mouse testicular explants with resulting sperm used to produce pups after Intra Cytoplasm Sperm Injection and Embryo Transfer. In the present study, we evaluated the influence of sphingosine-1-phosphate (S1P) on spermatogenesis of frozen-thawed lamb testis explants in vitro. Thawed testicular pieces were cultured for 12 d on agarose blocks in serum-free growth medium containing 0, 2, 5 or 10 μM S1P. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.038DOI Listing
January 2019

Comparative proteomic identification of capacitation and noncapacitation swamp buffalo spermatozoa.

Theriogenology 2019 Feb 7;128:176-183. Epub 2019 Feb 7.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning, 530004, Guangxi, PR China. Electronic address:

To investigate the proteomic profiling in buffalo spermatozoa before and after capacitation, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) combined with Tandem Mass Tag (TMT) labeling strategy was applied. As a result, 1461 proteins were identified, 93 of them were found to be differentially expressed (>1.5-fold), including 52 up-regulated proteins and 41 down-regulated proteins during sperm capacitation. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.02.002DOI Listing
February 2019

Succession of organics metabolic function of bacterial community in response to addition of earthworm casts and zeolite in maize straw composting.

Bioresour Technol 2019 Feb 4;280:229-238. Epub 2019 Feb 4.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

Succession and metabolism functions of bacterial communities were determined in maize straw composting with earthworm casts and zeolite addition by using high-throughput sequencing, Biolog and PICRUSt. Results showed that earthworm casts and zeolite addition increased the temperature, decreased NH contents and affected bacterial community structure. The relative abundances of Firmicutes and Betaproteobacteria increased with earthworm casts and zeolite addition in the late stage. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.015DOI Listing
February 2019

Discovery of endogenous retroviruses with mammalian envelopes in avian genomes uncovers long-term bird-mammal interaction.

Virology 2019 Feb 8;530:27-31. Epub 2019 Feb 8.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address:

Endogenous retroviruses (ERVs) arise from the infection and integration of past retroviruses into animal hosts. We performed large-scale genomic mining of 101 avian genomes for discovery of ERVs having none-avian origin and investigated the cross-species transmission events. Phylogenetic analysis of the reverse transcriptase (RT) of polymerase gene (pol) and the transmembrane subunit (TM) of the envelope gene (env) supported that avian ERVs with a mammalian env gene existed in at least 15 avian species and can be divided into two major groups: Group-1 were of recombinant ERVs with an alpha-like pol gene and a gamma-like env gene, and Group-2 included ERVs with both gamma-like pol and env genes. Read More

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http://dx.doi.org/10.1016/j.virol.2019.02.005DOI Listing
February 2019

Unmasking the identity of toxigenic cyanobacteria driving a multi-toxin bloom by high-throughput sequencing of cyanotoxins genes and 16S rRNA metabarcoding.

Sci Total Environ 2019 Feb 6;665:367-378. Epub 2019 Feb 6.

Departamento de Biología, C/Darwin, 2, Universidad Autónoma de Madrid, ES-28049 Madrid, Spain. Electronic address:

Cyanobacterial harmful algal blooms (CyanoHABs) are complex communities that include coexisting toxic and non-toxic strains only distinguishable by genetic methods. This study shows a water-management oriented use of next generation sequencing (NGS) to specifically pinpoint toxigenic cyanobacteria within a bloom simultaneously containing three of the most widespread cyanotoxins (the hepatotoxins microcystins, MCs; and the neurotoxins anatoxin-a, ATX, and saxitoxins, STXs). The 2013 summer bloom in Rosarito reservoir (Spain) comprised 33 cyanobacterial OTUs based on 16S rRNA metabarcoding, 7 of which accounted for as much as 96. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.083DOI Listing
February 2019

Dissemination of Escherichia coli carrying plasmid-mediated quinolone resistance (PMQR) genes from swine farms to surroundings.

Sci Total Environ 2019 Jan 25;665:33-40. Epub 2019 Jan 25.

College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China. Electronic address:

Different samples were collected from three swine farms in China to investigate the spread of antibiotic-resistant Escherichia coli. A total of 130 E. coli isolates were obtained from feces, air, river water, silt, and soil samples and characterized. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.272DOI Listing
January 2019

Gestational exposure to PM impairs vascularization of the placenta.

Sci Total Environ 2019 Feb 7;665:153-161. Epub 2019 Feb 7.

College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China. Electronic address:

The placenta is the bridge that connects the developing fetus and mother and is the place where nutrient uptake, waste elimination and gas exchange occurs. Epidemiological studies indicate that fetal stress, such as gestational PM (particulate matter (PM) with diameter ≤ 2.5 μm) exposure, is a risk factor for abnormal placenta development that could induce adverse effects on the fetus. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.101DOI Listing
February 2019

Phenanthrene-triggered tricarboxylic acid cycle response in wheat leaf.

Sci Total Environ 2019 Feb 8;665:107-112. Epub 2019 Feb 8.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA.

Tricarboxylic acid cycle (TCA cycle) is the most effective energy metabolism pathway in higher plants and animals. However, there is no information about its response in plants under environmental stress, especially under polycyclic aromatic hydrocarbons (PAHs) pollution. Here, this study is the first to discuss the intermediate and related enzyme changes in TCA cycle in plants. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.119DOI Listing
February 2019

Curation and bioinformatic analysis of strabismus genes supports functional heterogeneity and proposes candidate genes with connections to RASopathies.

Gene 2019 Feb 14. Epub 2019 Feb 14.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Strabismus refers to the misalignment of the eyes and occurs in 2-4% of individuals. The low-resolution label "strabismus" covers a range of heterogeneous defects, which makes it challenging to unravel this condition. Consequently a coherent understanding of the causes is lacking. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.020DOI Listing
February 2019

Overexpression of DNMT3A promotes proliferation and inhibits differentiation of porcine intramuscular preadipocytes by methylating p21 and PPARg promoters.

Gene 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address:

Intramuscular fat (IMF), which is modulated by the number and size of intramuscular preadipocytes, plays a key role in pork quality. DNA (cytosine-5)-methyltransferase 3A (DNMT3A), an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, is involved in the management of diverse intracellular processes. However, the physiological functions of DNMT3A in proliferation and differentiation of porcine intramuscular preadipocytes have not been clearly established. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.029DOI Listing
February 2019

In vitro osteogenic differentiation potential of the human induced pluripotent stem cells augment when grown on graphene oxide-modified nanofibers.

Gene 2019 Feb 14. Epub 2019 Feb 14.

Department of Tissue engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Due to the several limitations that surgeons are faced during bone tissue implantation there are daily increases in introducing new cell-co-polymer composites for use in bone tissue engineering approaches. In this study tried to develop a suitable nanostructured bio-composite for enhancing osteogenic differentiation of the human induced pluripotent stem cells (iPSCs). Polyvinylidene fluoride-Graphene oxide (PVDF-GO) nanofibers was fabricated by electrospinning and then characterized using scanning electron microscope, tensile and viability assays. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.028DOI Listing
February 2019

Cross-talk between the Ras GTPase and the Hog1 survival pathways in response to nitrosative stress in Paracoccidioides brasiliensis.

Nitric Oxide 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmaceutical Sciences, Universidade Federal de São Paulo, Campus Diadema, SP, Brazil; Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, SP, Brazil. Electronic address:

Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that cause paracoccidioidomycosis (PCM), the major systemic mycosis in Latin America. The capacity to evade the innate immune response of the host is due to P. brasiliensis ability to respond and to survive the nitrosative stress caused by phagocytic cells. Read More

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http://dx.doi.org/10.1016/j.niox.2019.02.002DOI Listing
February 2019

STING-associated lung disease in mice relies on T cells but not type I interferon.

J Allergy Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Pathology and Immunology, Saint Louis, MO, USA 63110; Molecular Microbiology, Saint Louis, MO, USA 63110; Washington University School of Medicine, Saint Louis, MO, USA 63110. Electronic address:

Background: Monogenic interferonopathies are thought to be mediated by type I interferon (IFN). For example, a gain-of-function mutation in STING (STING N153S) up-regulates type I IFN-stimulated genes (ISGs) and causes perivascular inflammatory lung disease in mice. The equivalent mutation in humans also causes lung disease, which is thought to require signaling through the cGAS-STING pathway and subsequent activation of IFN regulatory factors (IRF) 3/7, type I IFN, and ISGs. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.044DOI Listing
February 2019

Enhanced type I interferon gene signature in primary antiphospholipid syndrome: Association with earlier disease onset and preeclampsia.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo (USP), Brazil.

Objective: Recently, two studies demonstrated that a relevant percentage of primary antiphospholipid syndrome (PAPS) patients had an upregulation of interferon (IFN) genes. However, 20%-28% of these patients had anti-dsDNA, a highly specific systemic lupus erythematosus (SLE) autoantibody. This study aimed to determine the prevalence of the type I IFN signature in the peripheral blood mononuclear cells of PAPS patients without specific SLE autoantibodies and search for its clinical associations. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.11.004DOI Listing
February 2019

The expression pattern of calcium signaling-related genes during smoltification of Salmo salar in productive conditions.

Comp Biochem Physiol B Biochem Mol Biol 2019 Feb 14. Epub 2019 Feb 14.

Instituto de Ciencias Marinas y Limnológicas, Universidad Austral de Chile, Valdivia, Chile; Centro Fondap de Investigación de Altas Latitudes (IDEAL), Universidad Austral de Chile, Valdivia, Chile. Electronic address:

Variations in the mRNA expression of hepatic and muscle genes that are related to calcium signaling were analyzed by real-time qPCR in farmed Atlantic salmon (Salmo salar L. 1758) to determine changes in expression between parr and smolt stages. These organs were selected due to their close relationship with calcium signaling and metabolism (e. Read More

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http://dx.doi.org/10.1016/j.cbpb.2019.02.002DOI Listing
February 2019

Imatinib inhibits the regrowth of human colon cancer cells after treatment with 5-FU and cooperates with vitamin D analogue PRI-2191 in the downregulation of expression of stemness-related genes in 5-FU refractory cells.

J Steroid Biochem Mol Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Immunology, Maria Sklodowska-Curie Institute - Oncology Center, 5 WK Roentgen Str., 02-781 Warszawa, Poland. Electronic address:

Conventional cytotoxic drugs preferentially eliminate differentiated cancer cells but spare relatively more resistant stem-like cancer cells capable to initiate recurrence. Due to cancer cell plasticity, the stem-like phenotype can be also acquired by cancer cells refractory to treatment with cytotoxic drugs. We investigated whether drugs inhibiting receptor tyrosine kinases could be used to target human colon cancer cells initiating cancer regrowth following conventional cytotoxic treatment. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.02.003DOI Listing
February 2019

The Arc gene: Retroviral heritage in cognitive functions.

Neurosci Biobehav Rev 2019 Feb 14. Epub 2019 Feb 14.

Laboratory for Neurobiology of Memory, P.K. Anokhin Research Institute of Normal Physiology, Baltiyskaya 8, Moscow, 125315, Russian Federation; Department of Neuroscience, National Research Center "Kurchatov Institute", Akademika Kurchatova pl. 1, Moscow, 123182, Russian Federation; Institute for Advanced Brain Studies, Lomonosov Moscow State University, Leninskie Gory 1, Moscow, 119991, Russian Federation. Electronic address:

Stabilization of neuronal plastic changes is mediated by transient gene expression, including transcription of the activity-regulated cytoskeleton-associated gene (Arc), also known as Arg 3.1. Arc is implicated in several types of synaptic plasticity, including synaptic scaling, long-term potentiation, and long-term depression. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.02.006DOI Listing
February 2019

The transcriptome landscapes of ovary and three oviduct segments during chicken (Gallus gallus) egg formation.

Genomics 2019 Feb 14. Epub 2019 Feb 14.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address:

The avian embryo develops within a specialized biological container (eggshell) that contains crucial nutritional compartments (albumen, yolk). We analyzed the transcriptome of ovary and three segments of oviduct, including magnum, isthmus and uterus in the chicken during egg formation. RNA-Seq libraries (42 in total) for ovary and three different parts of the oviduct were sequenced for two different phases of egg formation. Read More

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http://dx.doi.org/10.1016/j.ygeno.2019.02.003DOI Listing
February 2019

Transcriptomic and microbiota response on Litopenaeus vannamei intestine subjected to acute sulfide exposure.

Fish Shellfish Immunol 2019 Feb 14. Epub 2019 Feb 14.

Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fishery Ecology and Environment, Guangdong Province, PR China; South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, PR China. Electronic address:

Harmful effects of water pollutants are myriad. Sulfide from water bodies affects the aquatic animals. Intestine barrier function serves as the front-line of animals defense. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.021DOI Listing
February 2019

Obeticholic acid differentially regulates hepatic injury and inflammation at different stages of D-galactosamine/lipopolysaccharide-evoked acute liver failure.

Eur J Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Toxicology, Anhui Medical University, Hefei, 230032, China. Electronic address:

The farnesoid X receptor (FXR) is a ligand-activated transcription factor that regulates genes involved in bile acid metabolism. Accumulating data demonstrate that FXR has an anti-inflammatory activity. The present study aimed to investigate the effect of obeticholic acid (OCA), a novel synthetic FXR agonist, on D-galactosamine (GalN)/lipopolysaccharide (LPS)-evoked acute liver injury. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.011DOI Listing
February 2019

Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders.

Cell Syst 2019 Jan 31. Epub 2019 Jan 31.

Institute for Systems Biology, Seattle, WA, USA; Institute of Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network (TRN) model for the human brain. We identified key regulator TFs whose predicted target genes were enriched for differentially expressed genes in the prefrontal cortex of individuals with psychiatric and neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.cels.2019.01.002DOI Listing
January 2019

Biological Evolution of Castration-resistant Prostate Cancer.

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

Context: Recent studies focused on the molecular characterization of metastatic prostate cancer have identified genomic subsets and emerging resistance patterns. Detection of these alterations in patients has potential implications for therapy selection and prognostication.

Objective: The primary objective is to review the current landscape of clinical and molecular biomarkers in advanced prostate cancer and understand how they may reflect underlying tumor biology. Read More

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http://dx.doi.org/10.1016/j.euf.2019.01.016DOI Listing
February 2019

Gene expression changes in cervical squamous cancers following neoadjuvant interventional chemoembolization.

Clin Chim Acta 2019 Feb 14. Epub 2019 Feb 14.

Medical College, Qingdao University, Qingdao 266021, Shandong, China.

Background: The efficacy of therapy for cervical cancer is related to the alteration of multiple molecular events and signaling networks during treatment. The aim of this study was to evaluate gene expression alterations in advanced cervical cancers before- and after-trans-uterine arterial chemoembolization- (TUACE).

Methods: Gene expression patterns in three squamous cell cervical cancers before- and after-TUACE were determined using microarray technique. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.012DOI Listing
February 2019

General detection of Shiga toxin 2 and subtyping of Shiga toxin 1 and 2 in Escherichia coli using qPCR.

J Microbiol Methods 2019 Feb 14. Epub 2019 Feb 14.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; Provincial Laboratory for Public Health, Alberta Public Health Laboratories, Edmonton, Alberta, Canada. Electronic address:

Shiga toxin-producing E. coli (STEC) is a gastrointestinal pathogen and has been recognized as one of the serious problems in public health. Shiga toxin genes (stx) can be grouped into different types according to their differences in sequence and biological activities. Read More

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http://dx.doi.org/10.1016/j.mimet.2019.02.008DOI Listing
February 2019

SOX2 epidermal overexpression promotes cutaneous wound healing via activation of EGFR/MEK/ERK signaling mediated by EGFR ligands.

J Invest Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA. Electronic address:

Oral mucosa contains a unique transcriptional network that primes oral wounds for rapid resolution in humans. Our previous work identified genes that were consistently upregulated in the oral mucosa and demonstrated that induction of one of the identified genes, transcription factor SOX2, promoted cutaneous wound healing in mice. In this study, we investigated the molecular and cellular mechanisms by which SOX2 accelerates wound healing in skin. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.004DOI Listing
February 2019

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Mol Metab 2019 Feb 5. Epub 2019 Feb 5.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: Administration of glucagon (GCG) or GCG-containing co-agonists reduces body weight and increases energy expenditure. These actions appear to be transduced by multiple direct and indirect GCG receptor (GCGR)-dependent mechanisms. Although the canonical GCGR is expressed in brown adipose tissue (BAT) the importance of BAT GCGR activity for the physiological control of body weight, or the response to GCG agonism, has not been defined. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.01.011DOI Listing
February 2019

Characterization of the salmon louse Lepeophtheirus salmonis miRNome: Sex-biased differences related to the coding and non-coding RNA interplay.

Mar Genomics 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Biotechnology and Aquatic Genomics, Interdisciplinary Center for Aquaculture Research (INCAR), University of Concepción, Concepción, Chile. Electronic address:

The salmon louse Lepeophtheirus salmonis is a marine ectoparasite that has a detrimental impact on salmon farms. Genomic knowledge of adult stages is critical to understand the reproductive success and lifecycle completion of this species. Here, we report a comprehensive characterization of the L. Read More

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http://dx.doi.org/10.1016/j.margen.2019.01.005DOI Listing
February 2019

Technical note: Bovine adipocyte and preadipocyte co-culture as an efficient adipogenic model.

J Dairy Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824. Electronic address:

Reductionist studies of adipose tissue biology require reliable in vitro adipocyte culturing models. Current protocols for adipogenesis induction in stromal vascular fraction-derived preadipocytes require extended culturing periods and have low adipogenic rates. We compared the adipogenic efficiency of a 7-d co-culture model of visceral (VIS) and subcutaneous (SC) stromal vascular fraction-derived preadipocytes with mature adipocytes with a 14-d standard adipocyte differentiation protocol. Read More

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http://dx.doi.org/10.3168/jds.2018-15626DOI Listing
February 2019

Analysis of the genetic architecture of energy balance and its major determinants dry matter intake and energy-corrected milk yield in primiparous Holstein cows.

J Dairy Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Animal Sciences, Functional Breeding Group, Georg-August-University Göttingen, D-37077 Göttingen, Germany; Center for Integrated Breeding Research, Georg-August-University Göttingen, D-37077 Göttingen, Germany.

The focus of modern dairy cow breeding programs has shifted from being mainly yield based toward balanced goals that increasingly consider functional traits such as fertility, metabolic stability, and longevity. To improve these traits, a less pronounced energy deficit postpartum is considered a key challenge. On the other hand, feed efficiency and methane emissions are gaining importance, possibly leading to conflicts in the design of breeding goals. Read More

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http://dx.doi.org/10.3168/jds.2018-15480DOI Listing
February 2019

A simple and rapid colorimetric bacteria detection method based on bacterial inhibition of glucose oxidase-catalyzed reaction.

Talanta 2019 May 11;197:304-309. Epub 2019 Jan 11.

State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address:

Rapid and sensitive detection of live bacteria is crucial in the realm of clinical diagnosis, food industry and environmental quality control. A portable, feasible and cost-effective platform which enables rapid and accurate live bacteria detection is still challenging. Herein, we present a Bacterial Inhibition of GOX-catalyzed Reaction (BIGR) method for rapid and broad-spectrum detection of live bacteria, which results in a visible color change without any complex instrumentations. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.039DOI Listing

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China.

Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0345-4DOI Listing
February 2019
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Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019

S. epidermidis strains from artisanal cheese made from unpasteurized milk in Poland - Genetic characterization of antimicrobial resistance and virulence determinants.

Int J Food Microbiol 2019 Feb 7;294:55-59. Epub 2019 Feb 7.

Chair of Industrial and Food Microbiology, Faculty of Food Science, University of Warmia and Mazury, Plac Cieszyński 1, 10-726 Olsztyn, Poland.

In Poland artisanal cheese production is an important local economic activity. Artisanal cheese is usually produced using raw cow's milk, animal rennet and salt, without the addition of starter cultures. Coagulase negative staphylococci (CoNS) are often present in artisanal cheeses. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.02.004DOI Listing
February 2019

Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway.

Ecotoxicol Environ Saf 2019 Feb 13;173:131-141. Epub 2019 Feb 13.

Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address:

The present study aimed to investigate whether melatonin (MT) treatment can attenuate immunotoxicity induced by aluminum chloride (AlCl) in rat spleen. Forty-eight healthy male Wistar rats were randomly allocated and treated with AlCl and/or MT. Rats were orally administered with AlCl for 90 days, from 61st days, rats were injected intraperitoneally with MT for 30 days. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.095DOI Listing
February 2019
2.762 Impact Factor

Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder.

J Psychiatr Res 2019 Feb 7;111:145-153. Epub 2019 Feb 7.

Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. Electronic address:

Gilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder that causes children to make repeated, brief involuntary movements or sounds. TS can be co-morbid with other neurodevelopmental disorders, including autism spectrum disorder (ASD). Clusters of biologically related genes have been associated with neurodevelopmental disorders, suggesting shared pathologies. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.023DOI Listing
February 2019
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