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Gen Dent 2022 Jul-Aug;70(4):67-71

Hereditary hemorrhagic telangiectasia (HHT) is a rare condition in which fragile vascular walls lead to increased risks of bleeding, cerebral abscesses, arteriovenous malformations, anemia, and thrombosis. To date, no protocol has been established for optimizing the clinical outcomes of periodontal treatment in patients with this condition. The aim of this case report is to describe a safe clinical approach to periodontal treatment in a patient with HHT. Read More

J Cutan Pathol 2021 Jan 20. Epub 2021 Jan 20.

Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.

J Cosmet Dermatol 2021 Apr 16;20(4):1086-1087. Epub 2021 Jan 16.

Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.

Generalized essential telangiectasia (GET) is a rare, clinically benign condition but a source of cosmetic concern for affected patients. There is a dearth of publications and known treatment options for GET. This case report reviews the clinical course of a 54-year-old woman who presented with a long-standing history of telangiectatic patches on her dorsal feet and ankles with progressive spread to the lower extremities consistent with GET. Read More

Dermatol Online J 2020 Oct 15;26(10). Epub 2020 Oct 15.

Department of Dermatology, Mater Hospital Brisbane, Queensland.

Cutaneous collagenous vasculopathy (CCV) is a rare idiopathic microangiopathy affecting superficial dermal blood vessels. It is characterized by asymptomatic, disseminated, telangiectatic macules that typically involve the extremities. We report the case of a 58-year-old woman who presented with widespread telangiectasias of three years' duration on the upper extremities and abdomen. Read More

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, New York.

The pathophysiology of generalized essential telangiectasia is not well understood. Generalized essential telangiectasia is an uncommon disorder in which widespread telangiectasias of unknown cause develop without associated systemic or antecedent dermatologic disease. We report a case of generalized essential telangiectasia in an otherwise healthy 49-year-old man. Read More

Vasc Med 2019 06 24;24(3):261-262. Epub 2018 Oct 24.

2 Dermatology, University Hospital Rennes.

Dermatol Online J 2018 May 15;24(5). Epub 2018 May 15.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.

Cutaneous collagenous vasculopathy (CCV) is a rare benign microangiopathy of the superficial dermal vessels. Clinically, it is characterized by widespread, asymptomatic development of cutaneous telangiectasia in the absence of systemic symptoms. Morphologically, it most resembles generalized essential telangiectasia and other telangiectatic syndromes such as telangiectasia macularis eruptiva perstans (TMEP), ataxia telangiectasia, and hereditary hemorrhagic telangiectasia. Read More

JAAD Case Rep 2018 Apr 21;4(3):217-219. Epub 2018 Feb 21.

Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, Dermatologist MD PhD, Complejo Hospitalario de Granada, Granada, Spain.

Essential generalized telangiectasia as the result of postcapillary venule dilatation, is characterized by the sudden development of generalized telangiectasias, sometimes involving the conjunctiva. A few pediatric cases have been reported. The main condition in the differential diagnosis includes syndromes with telangiectasia such as hereditary hemorrhagic telangiectasia of Rendu-Osler, unilateral nevoid telangiectasia, and neonatal lupus erythematous. Read More

J Dtsch Dermatol Ges 2018 Jan 17;16(1):92-94. Epub 2017 Nov 17.

Department of Dermatology, Ruprecht Karls University, Heidelberg, Germany.

Rev Med Interne 2018 Nov 6;39(11):896-897. Epub 2017 Jul 6.

Département de médecine vasculaire, centre hospitalier universitaire de Grenoble, CS 10217, 38043 Grenoble cedex 9, France; UMR 1042-HP2, Inserm, université Grenoble Alpes, 38000 Grenoble, France. Electronic address:

J Drugs Dermatol 2017 Mar;16(3):280-282

Generalized essential telangiectasia (GET) is a notoriously difficult to treat disorder with no current satisfactory treatments. This case and discussion report the use of 6-mercaptopurine (6-MP) as a successful treatment for GET. Moreover, we show that GET may represent a state of increased angiogenesis, a paradigm shift from the current understanding that these telangiectasias represent dilatations of only pre-existing vessels. Read More

Actas Dermosifiliogr 2017 Apr 21;108(3):e21-e26. Epub 2016 Sep 21.

Servicio de Anatomía Patológica, Hospital Universitari Son Espases, Palma de Mallorca, España.

The late development of symmetrical, ascending telangiectasias over an extensive area of the skin with no associated systemic manifestations is a common presentation of generalized essential telangiectasia (GET). It was recently suggested that cutaneous collagenous vasculopathy (CCV) is clinically identical to GET but that the 2 conditions can be distinguished by their distinctive histopathologic findings. We present 2 patients, both women, with multiple telangiectasias and describe the histopathologic findings that led to the diagnoses of GET and CCV. Read More

Indian Dermatol Online J 2016 Jan-Feb;7(1):40-2

Department of Dermatology, Seth GS Medical College, KEM Hospital, Mumbai, Maharashtra, India.

Cutaneous collagenous vasculopathy (CCV) is a distinct, rare, and underdiagnosed condition. We report a case of CCV in a 50-year-old woman presenting as asymptomatic, erythematous to hyperpigmented nonblanchable macules over both the lower extremities. The clinical differential diagnosis of the lesions was pigmented purpuric dermatoses (Schamberg's purpura) and cutaneous small vessel vasculitis. Read More

J Clin Aesthet Dermatol 2015 Nov;8(11):49-52

Vanderbilt University.

Cutaneous collagenous vasculopathy is a rare microangiopathy of dermal blood vessels. Clinically indistinguishable from generalized essential telangiectasia, this condition is diagnosed by its unique histological appearance. In contrast to other primary telangiectatic processes, cutaneous collagenous vasculopathy has dilated vascular structures that contain deposits of eosinophilic hyaline material within the vessel walls. Read More

BMJ Case Rep 2015 Jul 8;2015. Epub 2015 Jul 8.

Dermatology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Cutaneous collagenous vasculopathy is a rare cutaneous microangiopathy of unknown aetiology with only 27 cases reported to date. It is characterised clinically by generalised cutaneous telangiectasias and microscopically by dilation and marked thickening of the walls of superficial dermal blood vessels. Differential diagnosis should be performed with other causes of disseminated telangiectasias, including generalised essential telangiectasia, from which it is clinically indistinguishable. Read More

Clin Exp Dermatol 2015 Jul 27;40(5):513-5. Epub 2015 Jan 27.

Royal Liverpool University Hospital, Liverpool, UK.

Generalized essential telangiectasia (GET) is a rare skin condition of unknown aetiology. We report a case of a 39-year-old man who presented to the ophthalmology department with reduced vision, and was diagnosed with generalized essential telangiectasia by indocyanine green and fluorescein angiography of his eyes. The patient was noted to have corneal neovascularization (which was responsible for his reduced visual acuity) and conjunctival telangiectases seen by angiography. Read More

Am J Dermatopathol 2015 May;37(5):368-75

Department of Pathology (Dermatopathology), St Joseph's Healthcare and McMaster University, Hamilton, Ontario, Canada.

Cutaneous collagenous vasculopathy (CCV) is a rare distinct idiopathic microangiopathy of the superficial cutaneous vasculature. Seven new cases are reported (6 females and 1 male) ranging in age from 42 to 85 years, with some showing unusual clinical and histopathological findings. All presented with macular telangiectases starting on the lower extremities and spreading progressively in 5 cases and were suspected to have generalized essential telangiectasia. Read More

J Cutan Pathol 2014 Apr 24;41(4):386-93. Epub 2014 Jan 24.

Department of Pathology (Dermatopathology), St. Joseph's Healthcare and McMaster University, Hamilton, Ontario, Canada.

Cutaneous collagenous vasculopathy (CCV) is a rare cutaneous microangiopathy that clinically resembles generalized essential telangiectasia with only 12 cases reported to date. The perivascular fibrosis is thought to be due to production of abnormal collagen by veil cells in the outer vessel walls as a result of unknown factors. This report is of an 84-year-old male with progressive telangiectasia. Read More

Hepatology 2014 Jun 28;59(6):2419-21. Epub 2014 Apr 28.

Department of Biomedicine, University Hospital Basel, University Basel, Basel, Switzerland.

Br J Haematol 2013 Apr 14;161(2):155. Epub 2013 Feb 14.

Service de médecine interne, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.

Dermatol Online J 2012 Dec 15;18(12):13. Epub 2012 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.

Generalized essential telangiectasia, which is a rare condition that is characterized by the progressive development of telangiectases on the skin, is a clinical diagnosis of exclusion. We present a 65-year-old man with a ten-month history of an asymptomatic eruption of the trunk and proximal aspects of the arms and hands that was comprised of macules and patches of telangiectases. The clinical presentation, associated diseases, hypotheses regarding pathogenesis, differential diagnoses, and reports on treatment modalities are reviewed. Read More

Dermatology 2012 19;225(1):1-8. Epub 2012 Jul 19.

Dermatology Service, Central University Hospital of Asturias, Oviedo, Spain.

Cutaneous collagenous vasculopathy (CCV) is an idiopathic microangiopathy with characteristic histological findings. It was described in 2000, and 9 cases have since been described. Two women of 83 and 74 years consulted for long-standing telangiectasias. Read More

J Cutan Pathol 2012 Aug 16;39(8):741-6. Epub 2012 Jul 16.

Cleveland Clinic - Anatomic Pathology and Dermatology, Cleveland, OH, USA.

Cutaneous collagenous vasculopathy is a rare microangiopathy of superficial dermal blood vessels. Patients present with telangiectatic macules, predominantly on the extremities. A skin biopsy specimen is necessary to distinguish cutaneous collagenous vasculopathy from generalized essential telangiectasia. Read More

Ann Dermatol Venereol 2012 May 20;139(5):381-6. Epub 2012 Apr 20.

Service de Dermatologie, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Bruxelles, Belgique.

Background: Cutaneous collagenous vasculopathy (CCV) is an entity first described in 2000 by Salama and Rosenthal [1]. Because of its rarity, we felt it opportune to report the present case.

Patients And Methods: We describe the case of a 47-year-old woman presenting with widespread telangiectasia distributed symmetrically on the legs, thighs and lower abdomen. Read More

Actas Dermosifiliogr 2010 Jun;101(5):444-7

Complejo Hospitalario Arquitecto Marcide-Novoa Santos, Ferrol, La Coruña, España.

Cutaneous collagenous vasculopathy is an idiopathic microangiopathy first described in 2000 by Salama and Rosenthal.It must not be confused with generalized essential telangiectasia. To date, all patients have been white men over the age of 50 years, most of whom had multiple pathologies, were taking multiple drugs, and had no family history of similar conditions or hemorrhagic disorders. Read More

J Am Acad Dermatol 2010 Nov 6;63(5):882-5. Epub 2010 May 6.

St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Cutaneous collagenous vasculopathy is characterized by generalized cutaneous telangiectasia and unique microscopic and ultrastructural vascular changes, consisting of marked collagen deposition within the vascular walls of the post-capillary venules in the superficial dermis. There are only 4 previous cases described in the medical literature, all in males, mostly middle-aged. We have recently seen two female patients with clinical and histopathologic features diagnostic of cutaneous collagenous vasculopathy, indicating that it is not restricted to males. Read More

Actas Dermosifiliogr 2010 Mar;101(2):192-3

Am J Clin Dermatol 2010 ;11(1):63-6

Department of Dermatology, Ed. Herriot Hospital, Lyon, France.

Cutaneous collagenous vasculopathy is a very rare entity first described in 2000, manifesting clinically with acquired, progressively diffuse, cutaneous telangiectases with a histologically distinct aspect, characterized by a thick hyaline collagenous wall. Its cause is unknown. Differential diagnosis includes mainly generalized essential telangiectasia and telangiectatic mastocytosis. Read More

Intern Med J 2009 Nov;39(11):781-3