10,312 results match your criteria Generalized Epilepsies on EEG


Neonatal SCN2A encephalopathy: A peculiar recognizable electroclinical sequence.

Epilepsy Behav 2020 Jun 27;111:107187. Epub 2020 Jun 27.

Services d'explorations fonctionnelles, Centre de médecine du sommeil, Hôpital Antoine-Béclère, AP-HP, Clamart, France; Service de pédiatrie, Centre hospitalier intercommunal André Grégoire, Montreuil, France. Electronic address:

Introduction: Sodium voltage-gated channel alpha subunit 2 (SCN2A) gene encodes the Nav1.2 subunit of voltage-gated sodium channel in pyramidal neurons. SCN2A gain-of-function mutations are identified more and more often with gene panels and whole exome sequencing. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107187DOI Listing

Inter-ictal EEG patterns in malformations of cortical development and epilepsy.

Clin Neurol Neurosurg 2020 Jun 15;196:106022. Epub 2020 Jun 15.

Department of Radiology, Krishna Institute of Medical Sciences, Secunderabad, India.

Objectives: Malformations of cortical Development (MCDs) are associated with refractory epilepsy. We evaluated scalp inter-ictal EEG patterns in various types of MCD, and its association with clinical features and seizure control.

Patients And Methods: Retrospective analysis of demographic, clinical, inter-ictal EEG and seizure outcome data of 665 patients with epilepsy and MCD with at least two years follow up was performed. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106022DOI Listing

EEG autoregressive modeling analysis: A diagnostic tool for patients with epilepsy without epileptiform discharges.

Clin Neurophysiol 2020 Jun 8;131(8):1902-1908. Epub 2020 Jun 8.

Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, ROC; Departments of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan, ROC. Electronic address:

Objective: Numerous types of nonepileptic paroxysmal events, such as syncopes and psychogenic nonepileptic seizures, may imitate epileptic seizures and lead to diagnostic difficulty. Such misdiagnoses may lead to inappropriate treatment in patients that can considerably affect their lives. Electroencephalogram (EEG) is a commonly used tool in assisting diagnosis of epilepsy. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.04.172DOI Listing

Clinico-electrographic characteristics and classification of genetic generalized epilepsy in Oman.

Epilepsy Res 2020 Jun 5;166:106380. Epub 2020 Jun 5.

Neurology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Purpose: There is a lack of information on the annual incidence of genetic generalized epilepsy (GGE) in the Arab countries, especially Oman. Ascertaining the true burden of illness has crucial implications for health policies and priorities. We aim to study the clinico-electrographic characteristics, classification, and annual incidence of GGE in Oman. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106380DOI Listing

Who seizes longest? Impact of clinical and demographic factors.

Epilepsia 2020 Jun 21. Epub 2020 Jun 21.

Department of Neurology, Epilepsy Center, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Objective: To investigate the impact of clinical and demographic parameters on the duration of focal onset seizures with and without secondary generalization using precise duration measurements from intracranial electroencephalographic (iEEG) recordings.

Methods: Patients with unifocal epilepsy syndromes and iEEG recording were retrospectively identified from the database of the local epilepsy center (2006-2016). Seizure duration was defined as time difference of iEEG seizure pattern onset and cessation. Read More

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http://dx.doi.org/10.1111/epi.16577DOI Listing

cTnI, BNP and CRP profiling after seizures in patients with drug-resistant epilepsy.

Seizure 2020 Jun 3;80:100-108. Epub 2020 Jun 3.

Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address:

Purpose: To profile serum levels of high sensitivity Troponin I (hs-cTnI), B-Type Natriuretic Peptide (BNP), and high sensitivity C Reactive Protein (hs-CRP), after epileptic seizures in patients with focal drug-resistant epilepsy, relating the results to the revised SUDEP-7 inventory.

Methods: We prospectively evaluated patients admitted to our Epilepsy Monitoring Unit. hs-cTnI, BNP, and hs-CRP were measured at admission and after the first seizure. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.06.003DOI Listing

Epileptic seizure detection using EEG signals and extreme gradient boosting.

J Biomed Res 2019 Aug;34(3):228-239

Data Science Department, Centre of Excellence in Information and Communication Technologies, Charleroi 6041, Belgium.

The problem of automated seizure detection is treated using clinical electroencephalograms (EEG) and machine learning algorithms on the Temple University Hospital EEG Seizure Corpus (TUSZ). Performances on this complex data set are still not encountering expectations. The purpose of this work is to determine to what extent the use of larger amount of data can help to improve the performances. Read More

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http://dx.doi.org/10.7555/JBR.33.20190016DOI Listing

Pitfalls in the diagnosis of Jeavons syndrome: a study of 32 cases and review of the literature.

Epileptic Disord 2020 Jun;22(3):281-290

Istanbul University, Cerrahpasa Medical Faculty, Department of Neurology, Istanbul, Turkey.

Jeavons syndrome (JS) is mainly characterized by eyelid myoclonia with or without absences. It is thought to be underdiagnosed rather than have a rare prevalence. We aimed to investigate the electroclinical features of JS to determine possible factors influencing the diagnosis. Read More

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http://dx.doi.org/10.1684/epd.2020.1162DOI Listing

The clinical spectrum of familial and sporadic idiopathic generalized epilepsy.

Epilepsy Res 2020 Jun 1;165:106374. Epub 2020 Jun 1.

Department of Neurology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 5000 Odense, Denmark; OPEN, Open Patient Data Explorative Network, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense, Denmark. Electronic address:

Objective: Although the genetic origin of Idiopathic/Genetic Generalized Epilepsy (IGE) is hardly disputed, only a minority of patients show Mendelian inheritance. We here questioned if clinical characteristics like long-term outcome and treatment response differ between patients with sporadic and familial IGE.

Methods: In a near-population based cohort of IGE patients, clinical characteristics, treatment response and family history of 443 IGE patients were analyzed. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106374DOI Listing

Multicenter intracranial EEG dataset for classification of graphoelements and artifactual signals.

Sci Data 2020 Jun 16;7(1):179. Epub 2020 Jun 16.

Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA.

EEG signal processing is a fundamental method for neurophysiology research and clinical neurology practice. Historically the classification of EEG into physiological, pathological, or artifacts has been performed by expert visual review of the recordings. However, the size of EEG data recordings is rapidly increasing with a trend for higher channel counts, greater sampling frequency, and longer recording duration and complete reliance on visual data review is not sustainable. Read More

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http://dx.doi.org/10.1038/s41597-020-0532-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297990PMC

Postictal generalized EEG suppression and postictal immobility: what do we know?

Epileptic Disord 2020 Jun;22(3):245-251

Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK, www.radar-cns.org.

Despite representing the leading cause of epilepsy-related mortality, the pathophysiology of sudden unexpected death in epilepsy (SUDEP) remains elusive. In this context, the identification of clinical markers of SUDEP assumes a great importance and has been the target of many studies aimed at stratifying patients' individual risk. Among the potentially most hazardous post-ictal phenomena observed following convulsive seizures in monitored SUDEP cases, postictal generalized EEG suppression and postictal immobility have attracted attention as potential SUDEP risk factors. Read More

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http://dx.doi.org/10.1684/epd.2020.1158DOI Listing

Clinical characteristics of functional (psychogenic nonepileptic) seizures: An international retrospective study.

Epilepsy Behav 2020 Jun 12;111:107197. Epub 2020 Jun 12.

Service de Neurologie, CHRU de NANCY et Pole Universitaire Adulte Du Grand Nancy, CPN, Laxou, France. Electronic address:

Purpose: We conducted a multicenter international cross-cultural comparative study to investigate clinical semiology and predisposing factors of functional seizures in a large cohort of patients living in different countries around the world. We hypothesized that semiology and predisposing factors of functional seizures differ between various world regions.

Methods: We conducted this retrospective observational study in adults with functional seizures admitted to epilepsy centers in Iran, Qatar, USA, France, Georgia, Egypt, and United Arab Emirates (UAE). Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107197DOI Listing

Genetic generalized epilepsies with frontal lesions mimicking migratory disorders on the epilepsy monitoring unit.

Epilepsia Open 2020 Jun 12;5(2):176-189. Epub 2020 Mar 12.

Epilepsy Center Bethel Krankenhaus Mara Bielefeld Germany.

Objective: Some patients with genetic generalized epilepsy (GGE) may present with ambiguous and atypical findings and even focal brain abnormalities. Correct diagnosis may therefore be difficult.

Methods: We retrospectively collected six patients investigated on the epilepsy monitoring unit with MRI abnormalities mimicking focal cortical dysplasia (FCD-like) or heterotopias, but with semiology and EEG features of GGE. Read More

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http://dx.doi.org/10.1002/epi4.12385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278548PMC

Which seizure elements do patients memorize? A comparison of history and seizure documentation.

Epilepsia 2020 Jun 9. Epub 2020 Jun 9.

Epilepsy Center, University Medical Center, University of Freiburg, Freiburg, Germany.

Objective: People with epilepsy (PWE) are frequently unable to recall the core manifestation of their disease, epileptic seizures. This means that seizure frequency is often underestimated by practitioners and that seizure classification based on reports of patients or their relatives is difficult because seizure semiology remains unclear. The purpose of this study, therefore, was to prospectively explore patients' memory regarding seizure elements and to assess the role of seizure types. Read More

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http://dx.doi.org/10.1111/epi.16550DOI Listing

Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.

Epilepsy Behav 2020 Jun 5;110:107161. Epub 2020 Jun 5.

Prasat Neurological Institute, Bangkok, Thailand.

Objective: The objective of the study was to assess the effects of antiepileptic drugs (AEDs) on posterior alpha rhythm and determine whether they produce pathological slow waves in patients with epilepsy.

Methods: Outpatient electroencephalographs (EEGs) in alert patients were selected. The three compared groups include 1) patients with an interested AED (monotherapy or combined with other AEDs); 2) patients with AEDs other than the interested AED; and 3) patients who did not take AEDs. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107161DOI Listing

Mutation in Infantile Epileptic Encephalopathy: Report of Two Cases.

J Epilepsy Res 2019 Dec 31;9(2):147-151. Epub 2019 Dec 31.

Department of Pediatric Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Early infantile epileptic encephalopathy type 13 is a severe form of epilepsy caused by mutations in the sodium channel 8 alpha (SCN8A) gene. This gene encodes the neuronal voltage-gated sodium channel which plays vital role in neuronal excitability. Here we present two cases with SCN8A encephalopathy. Read More

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http://dx.doi.org/10.14581/jer.19017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251340PMC
December 2019

Recent Aspects of Pediatric Epilepsy Surgery.

J Epilepsy Res 2019 Dec 31;9(2):87-92. Epub 2019 Dec 31.

Division of Pediatric Neurology, Department of Pediatrics, Pediatric Epilepsy Clinic, Severance Children's Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Surgery has been and is now a well-established treatment indicated for adults and children with drug-resistant epilepsy (DRE). The surgical landscape for children with DRE appears to be expanding, and surgical cases of pediatric epilepsy have increased significantly in the past decade, contrary to adult epilepsy. Several fundamental changes have led to the widespread surgical treatment for DRE in children, based on a risk-benefit analysis of pediatric epilepsy surgery, and a change in our overall approach to evaluation. Read More

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http://dx.doi.org/10.14581/jer.19010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251342PMC
December 2019

Light-emitting-diode and Grass PS 33 xenon lamp photic stimulators are equivalent in the assessment of photosensitivity: Clinical and research implications.

Epilepsy Res 2020 Jun 1;165:106377. Epub 2020 Jun 1.

Department of Clinical Neurophysiology, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK; School of Life and Health Sciences, Aston Neuroscience Institute, Aston University, Birmingham, UK. Electronic address:

The assessment of the effect of photic stimulation is an integral component of an EEG exam and is especially important in patients referred for ascertained or suspected photosensitivity with or without a diagnosis of epilepsy. A positive test result relies on eliciting a specific abnormality defined as the "photoparoxysmal response". Reliability of this assessment is strongly influenced by technical and procedural variables, a critical one represented by the physical properties of the stimulators used. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106377DOI Listing

Idiopathic (genetic) generalized epilepsies with absences: clinical and electrographic characteristics and seizure outcome.

Neurol Sci 2020 Jun 6. Epub 2020 Jun 6.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: We compared various syndromes of idiopathic (genetic) generalized epilepsy (IGE) with absences based on their demographic, clinical, and electroencephalographic (EEG) findings, and their seizure outcome.

Methods: In this retrospective study, all patients with a clinical diagnosis of childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), idiopathic epilepsy with phantom absences (PAs), and Jeavons syndrome (JS) were recruited at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, from 2008 until 2019. Age, gender, age at seizure onset, seizure type(s), epilepsy risk factors, history of seizure-related injuries, EEG findings, and seizure outcome of all patients were registered routinely. Read More

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http://dx.doi.org/10.1007/s10072-020-04490-7DOI Listing

Selective Posterior Callosotomy for Treatment of Epileptic Drop Attacks: Video Documentation of the Surgical Technique: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Jun 5. Epub 2020 Jun 5.

Epilepsy Surgery Program, Department of Neurosurgery and Neurology , Hospital São Lucas, Porto Alegre, RS, Brazil.

This is a surgical technique video of selective posterior callosotomy (SPC), a novel surgical procedure to alleviate refractory epileptic drop attacks.1 Departing from traditional approaches aiming the anterior half or the entire callosum, SPC sections the posterior half of the callosum sparing prefrontal connectivity.1 Drop attacks are generalized epileptic seizures characterized by sudden falls. Read More

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http://dx.doi.org/10.1093/ons/opaa137DOI Listing

Hypnagogic Frontal EEG Bursts in Children: Epileptic or Not?

Authors:
Anita N Datta

J Clin Neurophysiol 2020 May 28. Epub 2020 May 28.

Division of Neurology, Department of Pediatrics, BC Children's Hospital, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Purpose: Various EEG patterns emerge in drowsiness. Intermittent bilateral midfrontal slowing (BFS) and hypnogogic frontal predominant sharply contoured waveforms (HFSC), maximal at (Fz, F3-4, and Fp1-2), are often encountered. These do not meet the criteria for epileptiform discharges. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000722DOI Listing

Brivaracetam in absence status epilepticus.

Seizure 2020 May 24;80:3-4. Epub 2020 May 24.

Epilepsy Center - SC. Neurologia Universitaria, Policlinico Riuniti, Foggia, Italy.

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http://dx.doi.org/10.1016/j.seizure.2020.05.015DOI Listing
May 2020
2.059 Impact Factor

Extracranial Interictal and Ictal EEG in sEEG Planning.

Neurosurg Clin N Am 2020 Jul 25;31(3):345-371. Epub 2020 Apr 25.

Department of Neurology, University of Florida, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32610, USA. Electronic address:

Analysis of scalp electroencephalogram (EEG) findings is indispensable to investigation of epilepsy surgery candidates. Maxima of slowing and epileptiform spiking on interictal EEG reflect gross localization of core epileptogenic regions within a network. Important negative scalp EEG findings are those associated with deep foci. Read More

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http://dx.doi.org/10.1016/j.nec.2020.03.008DOI Listing

GABA receptor β3 subunit mutation D120N causes Lennox-Gastaut syndrome in knock-in mice.

Brain Commun 2020 10;2(1):fcaa028. Epub 2020 Mar 10.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

The Lennox-Gastaut syndrome is a devastating early-onset epileptic encephalopathy, associated with severe behavioural abnormalities. Its pathophysiology, however, is largely unknown. A mutation (c. Read More

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http://dx.doi.org/10.1093/braincomms/fcaa028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238755PMC

Post-ictal accelerometer silence as a marker of post-ictal immobility.

Epilepsia 2020 May 27. Epub 2020 May 27.

Division of Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Objective: Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complications and with sudden unexpected death in epilepsy (SUDEP). Read More

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http://dx.doi.org/10.1111/epi.16552DOI Listing

Periictal electroclinical characteristics of postictal generalized electroencephalographic suppression after generalized convulsive seizures.

Medicine (Baltimore) 2020 May;99(20):e19940

Department of Neurology, West China Hospital of Sichuan University.

The aim of this study was to investigate the demographic, clinical, and electrophysiological characteristics of postictal generalized electroencephalography (EEG) suppression (PGES), thereby facilitating the recognition of PGES and providing clues regarding its risk factors, pathophysiology, and relationship with sudden unexpected death in epilepsy patients (SUDEP).We retrospectively reviewed 237 generalized convulsive seizures (GCSs) in 126 patients during long-term video-EEG (VEEG) recordings. The associations of PGES and prolonged PGES (duration >20 seconds) with person- and seizure-specific variables were evaluated independently using SPSS software. Read More

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http://dx.doi.org/10.1097/MD.0000000000019940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254049PMC

Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.

Brain 2020 May 21. Epub 2020 May 21.

Cerebral dynamics, learning and plasticity, Integrative Neuroscience and Cognition Center - UMR 8002, Paris, France.

Absence seizures in children and teenagers are generally considered relatively benign because of their non-convulsive nature and the large incidence of remittance in early adulthood. Recent studies, however, show that 30% of children with absence seizures are pharmaco-resistant and 60% are affected by severe neuropsychiatric comorbid conditions, including impairments in attention, cognition, memory and mood. In particular, attention deficits can be detected before the epilepsy diagnosis, may persist even when seizures are pharmacologically controlled and are aggravated by valproic acid monotherapy. Read More

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http://dx.doi.org/10.1093/brain/awaa072DOI Listing

Peri-ictal heart rate variability parameters as surrogate markers of seizure severity.

Epilepsia 2020 May 21. Epub 2020 May 21.

Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark.

This study aims at defining objective parameters reflecting the severity of peri-ictal autonomic changes and their relation to post-ictal generalized electroencephalography (EEG) suppression (PGES), with the view that such changes could be detected by wearable seizure detection systems and prove useful to assess the risk of sudden unexpected death in epilepsy (SUDEP). To this purpose, we assessed peri-ictal changes in heart rate variability (HRV) and correlated them with seizure duration, intensity of electromyography-based ictal muscle activity, and presence and duration of post-ictal generalized EEG suppression (PGES). We evaluated 75 motor seizures from 40 patients, including 61 generalized tonic-clonic seizures (GTCS) and 14 other major motor seizure types. Read More

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http://dx.doi.org/10.1111/epi.16491DOI Listing

Clinical and Electroencephalographic Features of the Seizures in Neuronal Surface Antibody-Associated Autoimmune Encephalitis.

Front Neurol 2020 5;11:280. Epub 2020 May 5.

Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

To investigate clinical and electroencephalographic features of the seizures in different types of neuronal surface antibody (NSAb)-associated autoimmune encephalitis (AE). The clinical data of the seizures were analyzed in 18 patients with NSAb-associated AEs diagnosed in the First Affiliated Hospital of Dalian Medical University. From May 2013 to April 2019, a total of 18 cases of NSAb-associated AE were diagnosed, including 9 cases of leucine-rich glioma-inactivated 1 protein (LGI1) antibody-associated encephalitis, 7 cases of anti--methyl-d-aspartate receptor (NMDAR) encephalitis, and 2 cases of anti-γ-aminobutyric acid B receptor (GABAR) encephalitis. Read More

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http://dx.doi.org/10.3389/fneur.2020.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214674PMC

Genetic/idiopathic generalized epilepsies: Not so good as that!

Rev Neurol (Paris) 2020 Jun 15;176(6):427-438. Epub 2020 May 15.

Epilepsy Unit, Hôpital Gui-de-Chauliac, 80, avenue Fliche, 34295 Montpellier cedex 05, France; Research Unit (URCMA : Unité de Recherche sur les Comportements et Mouvements Anormaux), Inserm, U661, 34000 Montpellier, France.

Genetic or idiopathic generalized epilepsies (IGEs) account for 15-20% of all epilepsies. These syndromes have always been considered as good prognosis forms of epilepsy over time; however, for some patients, there is a need to maintain antiseizure drugs (ASD) for a long-time. Drug resistance is not uncommon (7-15%). Read More

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http://dx.doi.org/10.1016/j.neurol.2020.03.018DOI Listing

Tramadol-associated seizures in Egypt: Epidemiological, clinical, and radiological study.

Neurotoxicology 2020 May 12;79:122-126. Epub 2020 May 12.

MD Neurology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:

Background: Tramadol intake related seizures have emerged as a common cause of seizures in Egypt affecting mainly young men.

Objective: This study aimed to determine the percentage of tramadol induced seizures, and to compare the clinical, neurophysiological, and radiological features of tramadol induced seizures group with idiopathic epilepsy group.

Methods: Two phases study; at first phase, data analysis for all Kasr-Alainy epilepsy clinic patients in Cairo during the period from January 2012 through June 2014, then at second phase a group of tramadol induced seizures' patients were compared with a matching group of idiopathic epilepsy patients. Read More

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http://dx.doi.org/10.1016/j.neuro.2020.05.002DOI Listing

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy.

Front Neurol 2020 28;11:245. Epub 2020 Apr 28.

Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.

Many physiological processes such as sleep, hormonal secretion, or thermoregulation, are expressed as daily rhythms orchestrated by the circadian timing system. A powerful internal clock mechanism ensures proper synchronization of vital functions within an organism on the one hand, and between the organism and the external environment on the other. Some of the pathological processes developing in the brain and body are subjected to circadian modulation as well. Read More

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http://dx.doi.org/10.3389/fneur.2020.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198737PMC

How to carry out and interpret EEG recordings in COVID-19 patients in ICU?

Clin Neurophysiol 2020 May 13. Epub 2020 May 13.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

There are questions and challenges regarding neurologic complications in COVID-19 patients. EEG is a safe and efficient tool for the evaluation of brain function, even in the context of COVID-19. However, EEG technologists should not be put in danger if obtaining an EEG does not significantly advance diagnosis or change management in the patient. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217782PMC

Ictal quantitative surface electromyography correlates with postictal EEG suppression.

Neurology 2020 Jun 12;94(24):e2567-e2576. Epub 2020 May 12.

From the Department of Clinical Neurophysiology (A.A.A., P.W., S.B.), Danish Epilepsy Centre, Dianalund, Denmark; Department of Clinical Neurosciences (A.A.A.), "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; FORCE Technology (I.C.), Hørsholm, Denmark; Brain Sentinel (D.P.C., L.E.W., S.R.V.), San Antonio, TX; Department of Clinical Medicine (P.W.), Neurological Service, Federal University of Santa Catarina, Florianópolis, SC, Brazil; Center for SUDEP Research (S.L.), National Institute of Neurological Disorders and Stroke, Bethesda, MD; Department of Neurology (S.L.), University of Texas Health Sciences Center at Houston; Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland; Department of Clinical Neurophysiology (S.B.), Aarhus University Hospital; and Department of Clinical Medicine (S.B.), Aarhus University, Denmark.

Objective: To test the hypothesis that neurophysiologic biomarkers of muscle activation during convulsive seizures reveal seizure severity and to determine whether automatically computed surface EMG parameters during seizures can predict postictal generalized EEG suppression (PGES), indicating increased risk for sudden unexpected death in epilepsy. Wearable EMG devices have been clinically validated for automated detection of generalized tonic-clonic seizures. Our goal was to use quantitative EMG measurements for seizure characterization and risk assessment. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009492DOI Listing

Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism.

Mol Brain 2020 May 12;13(1):76. Epub 2020 May 12.

Department of Neurology, Vanderbilt University Medical Center, Nashville, USA.

Mutations in SLC6A1, encoding γ-aminobutyric acid (GABA) transporter 1 (GAT-1), have been recently associated with a spectrum of epilepsy syndromes, intellectual disability and autism in clinic. However, the pathophysiology of the gene mutations is far from clear. Here we report a novel SLC6A1 missense mutation in a patient with epilepsy and autism spectrum disorder and characterized the molecular defects of the mutant GAT-1, from transporter protein trafficking to GABA uptake function in heterologous cells and neurons. Read More

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http://dx.doi.org/10.1186/s13041-020-00612-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218610PMC

An Overview of the Electroencephalographic (EEG) Features of Epilepsy with Eyelid Myoclonia (Jeavons Syndrome).

Neurodiagn J 2020 Jun 5;60(2):113-127. Epub 2020 May 5.

Epilepsy Center, Neurological Institute, Cleveland Clinic , Cleveland, Ohio.

Epilepsy with eyelid myoclonia or Jeavons Syndrome is a unique idiopathic generalized epilepsy with onset in childhood. It is characterized by eyelid myoclonia which may be associated with absence seizures, eyelid closure-induced epileptiform discharges and/or seizures and photosensitivity. It is frequently underrecognized and misdiagnosed because it may be mistaken for some other type of generalized epilepsy or facial tic disorder. Read More

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http://dx.doi.org/10.1080/21646821.2020.1750879DOI Listing

Tablet-based electroencephalography diagnostics for patients with epilepsy in the West African Republic of Guinea.

Eur J Neurol 2020 May 2. Epub 2020 May 2.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Background And Purpose: Epilepsy is most common in lower-income settings where access to electroencephalography (EEG) is generally poor. A low-cost tablet-based EEG device may be valuable, but the quality and reproducibility of the EEG output are not established.

Methods: Tablet-based EEG was deployed in a heterogeneous epilepsy cohort in the Republic of Guinea (2018-2019), consisting of a tablet wirelessly connected to a 14-electrode cap. Read More

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http://dx.doi.org/10.1111/ene.14291DOI Listing
May 2020
4.055 Impact Factor

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls.

Front Pharmacol 2020 14;11:395. Epub 2020 Apr 14.

Donders Centre for Cognition, Radboud University, Nijmegen, Netherlands.

The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as models for generalized genetic epilepsy and in particular for childhood absence epilepsy. These animal models were described in the eighties of the previous century and both models have, among others, face, construct and predictive validity. Both models were and are currently used as models to predict the action of antiepileptic medication and other experimental treatments, to elucidate neurobiological mechanisms of spike-wave discharges and epileptogenesis. Read More

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http://dx.doi.org/10.3389/fphar.2020.00395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175742PMC

Generalized tonic-clonic seizures with post-ictal atrial fibrillation.

Epilepsy Behav Rep 2020 30;13:100343. Epub 2019 Oct 30.

Department of Neurology, University of Louisville, 500 South Jackson Street, Louisville, KY 40202, USA.

Convulsive seizures are known to cause severe cardiopulmonary changes and increased autonomic activity. Limited reports describe peri-ictal cardiac arrhythmias such as atrial fibrillation (AF) with generalized tonic-clonic seizures (GTCS). We present a unique case of a healthy 23-year-old male patient with new onset prolonged AF in the setting of new onset seizures, occurring on three independent occasions. Read More

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http://dx.doi.org/10.1016/j.ebr.2019.100343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170332PMC
October 2019

Treatment of generalized convulsive status epilepticus: An international survey in the East Mediterranean Countries.

Seizure 2020 May 10;78:96-101. Epub 2020 Apr 10.

Comprehensive Epilepsy Program, Neurology Department, American University of Beirut Medical Center, Lebanon. Electronic address:

Purpose: Three Chapters of the Commission of the East Mediterranean Affairs (CEMA) of the ILAE conducted a survey to assess the availability of drugs used for the treatment of generalized convulsive status epilepticus (GCSE) across the CEMA countries and to evaluate the treatment choices of adult and pediatric neurologists for the treatment of this condition.

Method: The web-based survey consisted of two similar vignettes of GCSE in a child and an adult. The questions evaluated the sequential drugs of choice based on drug availability and with the assumption that all drugs were at the disposition of the neurologists. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.03.016DOI Listing

Rhythmic Network Modulation to Thalamocortical Couplings in Epilepsy.

Int J Neural Syst 2020 Apr 18:2050014. Epub 2020 Apr 18.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.

Thalamus interacts with cortical areas, generating oscillations characterized by their rhythm and levels of synchrony. However, little is known of what function the rhythmic dynamic may serve in thalamocortical couplings. This work introduced a general approach to investigate the modulatory contribution of rhythmic scalp network to the thalamo-frontal couplings in juvenile myoclonic epilepsy (JME) and frontal lobe epilepsy (FLE). Read More

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http://dx.doi.org/10.1142/S0129065720500148DOI Listing

[A case of refractory generalized atonic seizure and hemifacial spasm with the possible causative pontocerebellar lesion].

Rinsho Shinkeigaku 2020 May 18;60(5):362-366. Epub 2020 Apr 18.

Department of Neurology, Kyoto University Graduate School of Medicine.

The patient was a 35-year-old woman. At the age of 1, she had undergone resection and radiation therapy for neoplastic lesions in the pons. She had a history of gelastic seizures when she was in elementary school, and brief lapses of the neck and truncal muscular tone and convulsions on the left face occurred at the age of 23. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001368DOI Listing

Late-onset idiopathic (genetic) generalized epilepsies: Clinical and EEG findings.

J Clin Neurosci 2020 Jun 15;76:58-60. Epub 2020 Apr 15.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Purpose: We investigated the occurrence and clinical characteristics of late-onset idiopathic generalized epilepsies (IGEs). We also provided a statistically meaningful definition for late-onset IGE in this large cohort of patients.

Methods: In this cross-sectional retrospective chart review study, all patients with a clinical diagnosis of IGE were recruited at the outpatient epilepsy clinic at Shiraz University of Medical Sciences from 2008 until 2019. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.049DOI Listing

A study of the significance of photoparoxysmal responses and spontaneous epileptiform discharges in the EEG in childhood epilepsy.

Epilepsy Behav 2020 Jun 15;107:107046. Epub 2020 Apr 15.

Department of Neurology & Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

Aim: In clinical practice, there is a prevailing notion that photosensitivity mostly occurs in children with epilepsy (CWE) with idiopathic generalized epilepsy. We investigated the distribution of epilepsy types and etiology in photosensitive children and the associations with specific clinical and electroencephalogram (EEG) variables.

Methods: In this retrospective cohort study, clinical data were acquired from all children that showed photosensitivity during systematic intermittent photic stimulation (IPS), over a 10-year interval at a tertiary level Children's Hospital, Winnipeg. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107046DOI Listing

Stereotactic radiofrequency thermocoagulation and resective surgery for patients with hypothalamic hamartoma.

J Neurosurg 2020 Apr 17:1-8. Epub 2020 Apr 17.

Departments of1Neurosurgery and.

Objective: In this study, the authors compared the efficacy and safety of stereotactic radiofrequency thermocoagulation (SRT) and resective surgery (RS) for patients with hypothalamic hamartoma (HH).

Methods: The authors included all patients with HHs who were treated by SRT or hamartoma resection. Seizure outcomes were assessed by blinded observers according to the International League Against Epilepsy (ILAE) classification. Read More

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http://dx.doi.org/10.3171/2020.2.JNS193423DOI Listing

Deep Versus Lobar Intraparenchymal Hemorrhage: Seizures, Hyperexcitable Patterns, and Clinical Outcomes.

Crit Care Med 2020 Jun;48(6):e505-e513

Department of Neurology/Comprehensive Epilepsy Center, Yale University School of Medicine, New Haven, CT.

Objectives: To compare electrographic seizures, hyperexcitable patterns, and clinical outcomes in lobar and deep intraparenchymal hemorrhage. Additionally, to characterize electrographic seizure and hyperexcitable pattern predictors in each group and determine seizure risk with thalamic involvement.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004317DOI Listing

Quantitative characteristics of spike-wave paroxysms in genetic generalized epilepsy.

Clin Neurophysiol 2020 Jun 23;131(6):1230-1240. Epub 2020 Mar 23.

Department of Neurology, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Objective: To characterize generalized spike-wave paroxysms (GSW) in children with generalized genetic epilepsy (GGE).

Methods: We annotated 15-19 channel scalp EEGs from a retrospective cohort from patients with a variety of GGE syndromes. Connectivity, entropy, frequency, power, spike-amplitudes were compared with a normal baseline activity and analyzed for the effect of age and sex. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.006DOI Listing

Reflex Epilepsy with Hot Water: Clinical and EEG Findings, Treatment, and Prognosis in Childhood.

Neuropediatrics 2020 Apr 15. Epub 2020 Apr 15.

Division of Child Neurology, Department of Pediatrics, Abant İzzet Baysal University, Bolu, Turkey.

Hot water epilepsy (HWE) is a subtype of reflex epilepsy in which seizures are triggered by the head being immersed in hot water. Hot water or bathing epilepsy is the type of reflex epilepsy most frequently encountered in our clinic. We describe our patients with HWE and also discuss the clinical features, therapeutic approaches, and prognosis. Read More

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http://dx.doi.org/10.1055/s-0040-1709455DOI Listing

Functional imaging of the piriform cortex in focal epilepsy.

Exp Neurol 2020 Aug 9;330:113305. Epub 2020 Apr 9.

Department of Neurology, University Hospital Zurich, Switzerland.

Experiments in animal models have identified specific brain regions such as the deep anterior piriform cortex as important for controlling the initiation or propagation of both generalized and focal seizure activity. However, there is little experimental evidence to translate these observations to the control of focal seizures in humans. Here, we summarize findings from different hemodynamic and neurotransmitter functional imaging studies in groups of patients with focal epilepsies arising from different cortical locations in support of a common area of brain dysfunction in focal epilepsies. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113305DOI Listing

Prevention of sudden unexpected death in epilepsy: current status and future perspectives.

Expert Rev Neurother 2020 May 26;20(5):497-508. Epub 2020 Apr 26.

Department of Epileptology, University Hospital Bonn, Bonn, Germany.

: Sudden unexpected death in epilepsy (SUDEP) affects about 1 in 1000 people with epilepsy, and even more in medically refractory epilepsy. As most people are between 20 and 40 years when dying suddenly, SUDEP leads to a considerable loss of potential life years. The most important risk factors are nocturnal and tonic-clonic seizures, underscoring that supervision and effective seizure control are key elements for SUDEP prevention. Read More

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http://dx.doi.org/10.1080/14737175.2020.1754195DOI Listing