9,918 results match your criteria Generalized Epilepsies on EEG


Berardinelli-Seip syndrome and progressive myoclonus epilepsy.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Child Neurology and Psychiatry Unit, "Regina Montis Regalis" Hospital, Mondovì.

Berardinelli-Seip syndrome, or congenital generalized lipodystrophy type 2 (CGL2), is characterized by a lack of subcutaneous adipose tissue and precocious metabolic syndrome with insulin resistance, resulting in diabetes, dyslipidaemia, hepatic steatosis, cardiomyopathy, and acanthosis nigricans. Most reported mutations are associated with mild, non-progressive neurological impairment. We describe the clinical and EEG data of a patient with progressive myoclonus epilepsy (PME), CGL2, and progressive neurological impairment, carrying a homozygous BSCL2 nonsense mutation. Read More

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http://dx.doi.org/10.1684/epd.2019.1038DOI Listing
February 2019

Regional specificity of cortico-thalamic coupling strength and directionality during waxing and waning of spike and wave discharges.

Sci Rep 2019 Feb 14;9(1):2100. Epub 2019 Feb 14.

Institute of Physiology I, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Spike-wave discharges (SWDs) on the EEG during absence epilepsy are waxing and waning stages of corticothalamic hypersynchrony. While the somatosensory cortex contains an epileptic focus, the role of thalamic nuclei in SWD generation is debated. Here we assess the contribution of distinct thalamic nuclei through multiple-site unit recordings in a genetic rat model of absence epilepsy and cross-correlation analysis, revealing coupling strength and directionality of neuronal activity at high temporal resolution. Read More

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http://dx.doi.org/10.1038/s41598-018-37985-7DOI Listing
February 2019

Ventilatory response to CO in patients with epilepsy.

Epilepsia 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Objective: Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO (hypercapnic ventilatory response [HCVR] or central respiratory CO chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs). Read More

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http://dx.doi.org/10.1111/epi.14660DOI Listing
February 2019

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019

Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
February 2019

Tonic Seizure as a Different Seizure Type Presented in Autoimmune Epilepsy Caused by Systemic Lupus Erythematosus.

J Nerv Ment Dis 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of JiLin University, Changchun, People's Republic of China.

The diagnosis of autoimmune epilepsy is often challenging, and may be misdiagnosed as epileptic disorders or viral encephalitis. Autoimmune epilepsy has a strong association with other autoimmune diseases, especially systemic lupus erythematosus (SLE). In addition, autoimmune epilepsy was reported to present with complex partial seizure (CPS), simple partial seizure (SPS), and secondarily generalized tonic-clonic seizure (sGTCS). Read More

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http://dx.doi.org/10.1097/NMD.0000000000000946DOI Listing
February 2019
1 Read

Cerebrospinal fluid changes following epileptic seizures unrelated to inflammation.

Eur J Neurol 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurology, University Medicine Greifswald, Greifswald.

Objective: Analyzing cerebrospinal fluid (CSF) is crucial in the diagnostic workup of epileptic seizures to rule out autoimmunity or infections as underlying cause. Therefore, the description of postictal changes in CSF is essential to differentiate between negligible and etiopathologically relevant changes in CSF profile.

Methods: A retrospective analysis of 247 patients newly diagnosed with epileptic seizures and CSF analysis during diagnostic workup was conducted. Read More

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http://dx.doi.org/10.1111/ene.13924DOI Listing
February 2019
2 Reads

Diagnostic usefulness of arterial spin labeling in MR negative children with new onset seizures.

Seizure 2019 Jan 27;65:151-158. Epub 2019 Jan 27.

Department of Pediatric, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. Electronic address:

Purpose: Arterial spine labeling (ASL) magnetic resonance imaging (MRI) is the non-invasive measurement of cerebral blood flow that can localize the seizure focus in patients with epilepsy. The aim of this study was to identify its utility for localizing the seizure focus in children with no structural lesion on MRI.

Methods: Forty-three consecutive children who underwent electroencephalography (EEG) and structural MRI, along with ASL for evaluation of newly developed seizures, were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183070
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http://dx.doi.org/10.1016/j.seizure.2019.01.024DOI Listing
January 2019
3 Reads

Concordance between the interictal focal EEG pattern and MRI lesions as a predictor of a favorable surgical outcome in patients with epileptic spasms: a Chinese study.

J Neurosurg Pediatr 2019 Feb 1:1-10. Epub 2019 Feb 1.

Departments of1Functional Neurosurgery and.

OBJECTIVEThe aim of this study was to evaluate the electro-clinical features, etiology, treatment, and postsurgical seizure outcomes in patients with intractable epileptic spasms (ESs).METHODSThe authors retrospectively studied the medical records of all patients who had presented with medically intractable ESs and had undergone surgery in the period between October 2009 and August 2015. The interictal electroencephalography (EEG) pattern, MRI studies, magnetoencephalography findings, and postsurgical seizure outcomes were compared. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18380DOI Listing
February 2019
2 Reads

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient.

Curr Opin Neurol 2019 Jan 28. Epub 2019 Jan 28.

NINDS Center for SUDEP Research and Texas Comprehensive Epilepsy Center, University of Texas Houston Health Sciences Center, Houston, Texas, USA.

Purpose Of Review: The current review updates our knowledge regarding sudden unexpected death in epilepsy patient (SUDEP) risks, risk factors, and investigations of putative biomarkers based on suspected mechanisms of SUDEP.

Recent Findings: The overall incidence of SUDEP in adults with epilepsy is 1.2/1000 patient-years, with surprisingly comparable figures in children in recently published population-based studies. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000668DOI Listing
January 2019

Magnetic resonance imaging and electroencephalography findings in a sample of Iranian patients with epilepsy.

J Res Med Sci 2018 28;23:106. Epub 2018 Dec 28.

Isfahan Neurosciences Research Centre, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The present study is aimed to evaluate the magnetic resonance imaging (MRI) and electroencephalography (EEG) findings based on characteristics variables in patients with epilepsy.

Materials And Methods: In this cross-sectional study, all patients with epilepsy who referred between March 2016 and March 2017 to Al-Zahra and Kashani Hospitals in Isfahan, Iran, were enrolled. The completed files of 199 patients were assessed to collect information about characteristic data and MRI and EEG findings. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327682PMC
December 2018
0.608 Impact Factor

Baclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Royal Perth Hospital, Perth, Australia.

Purpose: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal and opiate dependency. Given the increasing use of baclofen we describe the clinical and electrographical features of baclofen neurotoxicity seen at our institution. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000565DOI Listing
January 2019
2 Reads

Expanding the Phenotypic Spectrum of CACNA1H Mutations.

Pediatr Neurol 2018 Dec 19. Epub 2018 Dec 19.

McGovern Medical School, UTHealth, Mitochondrial Center of Excellence, Houston, Texas.

Background: The CACNA1H gene mutations encoding the α subunit of Cav3.2 T-type calcium channels have been associated with generalized epilepsy. Focal or multifocal epilepsy and systemic (immunologic and gastrointestinal) involvement associated with these mutations have not been described previously. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.017DOI Listing
December 2018
1 Read

Chewing induced reflex seizures ("eating epilepsy") and eye closure sensitivity as a common feature in pediatric patients with SYNGAP1 mutations: Review of literature and report of 8 cases.

Seizure 2018 Dec 22;65:131-137. Epub 2018 Dec 22.

Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria; Hospital for Neuropediatrics and Neurological Rehabilitation, Epilepsy Center for Children and Adolescents, Krankenhausstr. 20, 83569 Vogtareuth, Germany.

Purpose: Heterozygous SYNGAP1 gene mutations have been associated with several forms of idiopathic generalized epilepsy, autism spectrum disorders and delay of psychomotor development. We report eight patients with a SYNGAP1 mutation and chewing/eating induced reflex seizures as new phenotype and compare them to other patients with eating epilepsy and genetic mutations.

Methods: Presentation of clinical and anamnestic features and retrospective analysis of Video-EEG data of a 4 year old index patient with SYNGAP1 mutation and chewing /eating induced seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183046
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http://dx.doi.org/10.1016/j.seizure.2018.12.020DOI Listing
December 2018
3 Reads

Cannabidiol (Epidiolex) for epilepsy.

Authors:

Med Lett Drugs Ther 2018 Nov;60(1559):182-184

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November 2018

Non-electroencephalography-based seizure detection.

Curr Opin Neurol 2019 Jan 15. Epub 2019 Jan 15.

Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus.

Purpose Of Review: There is need for automated seizure detection using mobile or wearable devices, for objective seizure documentation and decreasing morbidity and mortality associated with seizures. Due to technological development, a high number of articles have addressed non-electroencephalography (EEG)-based seizure detection. However, the quality of study-design and reporting is extremely heterogeneous. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000658DOI Listing
January 2019
1 Read

Brain Morphology in Patients with Genetic Generalized Epilepsy: Its Heterogeneity among Subsyndromes.

Eur Neurol 2019 Jan 18;80(5-6):136-144. Epub 2019 Jan 18.

Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Background: We aimed to evaluate the brain morphology of patients with genetic generalized epilepsy (GGE) compared to healthy subjects. In addition, we investigated whether there are differences in brain morphology among different GGE syndromes.

Methods: We enrolled 100 patients with a clinical diagnosis of GGE. Read More

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http://dx.doi.org/10.1159/000496698DOI Listing
January 2019
2 Reads

The utility of Jerk-locked back averaging technique in diagnosis of generalized myoclonic epilepsy with normal scalp EEG: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14185

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, 71, Xinmin Street, Changchun, P. R. China.

Rationale: The diagnosis of myoclonic epilepsy and the classification of generalized or partial type may be challenging, especially when the scalp electroencephalogram (EEG) is normal. In such situation, how to apply another electrophysiological technique to begin the diagnosis and classification? The utility of Jerk-locked back averaging technique has been described in our case.

Patient Concerns: A Chinese patient (male, 21 years old) presented with frequent unilateral or bilateral shoulder-jerking. Read More

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http://dx.doi.org/10.1097/MD.0000000000014185DOI Listing
January 2019

Blood markers of cardiac stress after generalized convulsive seizures.

Epilepsia 2019 Feb 15;60(2):201-210. Epub 2019 Jan 15.

Department of Epileptology, University Hospital Bonn, Bonn, Germany.

Objective: Generalized convulsive seizures (GCS) are associated with high demands on the cardiovascular system, thereby facilitating cardiac complications. To investigate occurrence, influencing factors, and extent of cardiac stress or injury, the alterations and time course of the latest generation of cardiac blood markers were investigated after documented GCS.

Methods: Adult patients with refractory epilepsy who underwent video-electroencephalography (EEG) monitoring along with simultaneous one-lead electrocardiography (ECG) recordings were included. Read More

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http://doi.wiley.com/10.1111/epi.14637
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http://dx.doi.org/10.1111/epi.14637DOI Listing
February 2019
3 Reads

Electroencephalographic and epilepsy findings in mecp2 duplication syndrome. A family study.

Brain Dev 2019 Jan 11. Epub 2019 Jan 11.

Clinical Pediatrics, Pediatric Neurology Center, Department of Molecular Medicine and Development, University of Siena, Siena, Italy. Electronic address:

MECP2 duplication syndrome (MECP2 DS) is an X-linked disorder characterized by early-onset hypotonia, poor speech development, recurrent respiratory infections, epilepsy and progressive spasticity. Epilepsy occurs in more than 50% of the affected patients. Generalized tonic-clonic seizures (GTCS) are the most common seizure-type described but atonic seizures, absences and myoclonic seizures have also been reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183019
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http://dx.doi.org/10.1016/j.braindev.2018.12.008DOI Listing
January 2019
4 Reads

Novel ANKRD11 gene mutation in an individual with a mild phenotype of KBG syndrome associated to a GEFS+ phenotypic spectrum: a case report.

BMC Med Genet 2019 Jan 14;20(1):16. Epub 2019 Jan 14.

Department of Biomedical Science, University of Sassari, Sassari, Italy.

Background: KBG syndrome is a very rare autosomal dominant disorder, characterized by macrodontia, distinctive craniofacial findings, skeletal findings, post-natal short stature, and developmental delays, sometimes associated with seizures and EEG abnormalities. So far, there have been over 100 cases of KBG syndrome reported.

Case Presentation: Here, we describe two sisters of a non-consanguineous family, both presenting generalized epilepsy with febrile seizures (GEFS+), and one with a more complex phenotype associated with mild intellectual disability, skeletal and dental anomalies. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-019-0745-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332862PMC
January 2019
6 Reads

Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression.

Epilepsia 2019 Feb 10;60(2):268-274. Epub 2019 Jan 10.

Department of Neurology, University of California Davis, Davis, California.

Objective: No biomarkers reliably predict risk for sudden unexpected death in epilepsy (SUDEP). Postictal generalized electroencephalography (EEG) suppression (PGES) is a possible biomarker for SUDEP risk. However, its utility in predicting SUDEP remains uncertain. Read More

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http://dx.doi.org/10.1111/epi.14632DOI Listing
February 2019
2 Reads

Epilepsy in children with type 1 diabetes mellitus: Pathophysiological basis and clinical hallmarks.

Eur J Paediatr Neurol 2018 Dec 21. Epub 2018 Dec 21.

Pediatric Diabetology Unit, Department of Maternal and Infantile Health, Sapienza University of Rome, Italy.

We provide an overview on the current knowledge about the association between epilepsy and type 1 diabetes mellitus (T1DM). People with T1DM have a 2-6-fold higher risk of epilepsy than the general population. The onset of T1DM anticipates the onset of epilepsy by a mean period between 1,5 and 2,8 years. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.006DOI Listing
December 2018
1 Read

Predictors of seizure in Wilson disease: A clinico-radiological and biomarkers study.

Neurotoxicology 2018 Dec 21;71:87-92. Epub 2018 Dec 21.

Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, India.

Background: There is paucity of studies on predictors of seizures in Wilson disease with neurological manifestation (WDNM), and none has evaluated the role of copper (Cu) induced oxidative stress, proinflammatory and excitotoxicity in the genesis of seizure.

Objectives: To report frequency, refractoriness, and outcome of seizure in WDNM. We also evaluate role of Cu induced oxidative stress, excitotoxicity and cytokines in predicting seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183033
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http://dx.doi.org/10.1016/j.neuro.2018.12.005DOI Listing
December 2018
9 Reads
3.379 Impact Factor

Driving status of patients with generalized spike-wave on EEG but no clinical seizures.

Epilepsy Behav 2018 Dec 20;92:5-13. Epub 2018 Dec 20.

Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

Generalized spike-wave discharges (SWDs) are the hallmark of generalized epilepsy on the electroencephalogram (EEG). In clinically obvious cases, generalized SWDs produce myoclonic, atonic/tonic, or absence seizures with brief episodes of staring and behavioral unresponsiveness. However, some generalized SWDs have no obvious behavioral effects. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.031DOI Listing
December 2018
5 Reads

Corpus callosotomy via laser interstitial thermal therapy: a case series.

J Neurosurg Pediatr 2018 Dec 21:1-5. Epub 2018 Dec 21.

Departments of1Neurological Surgery and.

Corpus callosotomy has been used as a form of surgical palliation for patients suffering from medically refractory generalized seizures, including drop attacks. Callosotomy has traditionally been described as involving a craniotomy with microdissection. MR-guided laser interstitial thermal therapy (MRg-LITT) has recently been used as a minimally invasive method for performing surgical ablation of epileptogenic foci and corpus callosotomy. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18368DOI Listing
December 2018

Hypoxemia following generalized convulsive seizures: Risk factors and effect of oxygen therapy.

Neurology 2019 Jan 19;92(3):e183-e193. Epub 2018 Dec 19.

From the Department of Functional Neurology and Epileptology (S.R., B.M.A., V.A.), Hospices Civils de Lyon and University of Lyon; Lyon's Neuroscience Research Center (S.R., B.M.A., V.A., L.B., P.R.), INSERM U1028/CNRS UMR 5292, France; Hospital of Clinics of Ribeirão Preto (V.A.), University of São Paulo, Brazil; Department of Neurology (J.C., L.V.), University Hospital of Toulouse; Neurology Department (L.M.), University Hospital of Nancy; Clinical Neurophysiology and Epileptology Department (F.B.), Timone Hospital, Marseille; Department of Clinical Neurophysiology (P.D.), Lille University Medical Center, EA 1046, University of Lille2; Department of Neurology (E.H.), University Hospital of Strasbourg; Department of Neurology (V.M.), Hôpital Pellegrin, Bordeaux; Epilepsy Unit, Department of Neurosurgery (F.C.), Centre Hospitalier Sainte-Anne, University Paris Descartes; La Teppe Epilepsy Center (D.T.), Tain l'Hermitage,; Epilepsy Unit (A.C.), Montpellier; Department of Neurology (A.B.), University Hospital of Rennes; Epileptology Unit (V.N.), Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière and Brain and Spine Institute (ICM; INSERM UMRS1127, CNRS UMR7225, UPMC University Paris 06); Department of Neurology (P.K.), Grenoble-Alpes University Hospital, GIN, INSERM U1216, and Grenoble Alpes University; Department of Clinical Neurophysiology (B.D.T.), INSERM U930, University Hospital of Tours; Department of Neurology (P.T.), University Hospital of Nice; Department of Neurology (S.R.), University Hospital of Clermont-Ferrand, France; Department of Clinical Neurosciences (S.R., P.R.), Centre Hospitalo-Universitaire Vaudois, Lausanne, Switzerland; and Epilepsy Institute (E.H., L.B., P.R.), Lyon, France.

Objective: To analyze the factors that determine the occurrence or severity of postictal hypoxemia in the immediate aftermath of a generalized convulsive seizure (GCS).

Methods: We reviewed the video-EEG recordings of 1,006 patients with drug-resistant focal epilepsy included in the REPOMSE study to identify those with ≥1 GCS and pulse oximetry (SpO) measurement. Factors determining recovery of SpO ≥ 90% were investigated using Cox proportional hazards models. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006777DOI Listing
January 2019
1 Read

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Neurology 2019 Jan 19;92(3):e171-e182. Epub 2018 Dec 19.

From the NINDS Center for SUDEP Research (L.V., M.R.S.R., R.K.S., D.F., M.N., C.S., B.K.G., B.Z., A.Z., S.S., J.O., R.M.H., B.D., L.B., O.D., G.B.R., P.R., S.D.L.); Epilepsy Center (L.V., N.L., J.P.H., N.J.H., N.S., X.Z., V.R.-M., S.D.L.) and Division of Pulmonary, Critical Care and Sleep Medicine (K.S.), University Hospitals Cleveland Medical Center, OH; University of Iowa School of Medicine (R.K.S., B.K.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.S., B.D.), University College London, UK; Feinberg School of Medicine (S.S.), Northwestern University, Chicago, IL; Department of Neurobiology and Brain Research Institute (J.O., R.M.H.), University of California, Los Angeles (UCLA); Department of Neurology (L.B.), Columbia University, New York, NY; and Department of Clinical Neuroscience (P.R.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Objective: To characterize peri-ictal apnea and postictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy.

Methods: This was a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of sudden unexpected death in epilepsy (SUDEP) in patients ≥18 years old with intractable epilepsy and monitored GCS. Video-EEG, thoracoabdominal excursions, nasal airflow, capillary oxygen saturation, and ECG were analyzed. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340388PMC
January 2019
12 Reads

Postictal electroencephalographic (EEG) suppression: A stereo-EEG study of 100 focal to bilateral tonic-clonic seizures.

Epilepsia 2019 Jan 22;60(1):63-73. Epub 2018 Nov 22.

Inserm, INS, Brain Dynamics Institute, Aix Marseille University, Marseille, France.

Objectives: We aimed to describe intracerebral aspects of postictal generalized electroencephalography suppression (PGES) following focal to bilateral tonic-clonic ("secondarily generalized tonic-clonic") seizures (GTCS) recorded using stereoelectroencephalographic (SEEG), and to correlate these with electroclinical features.

Methods: Three independent observers scored semiologic and SEEG features. Patient and epilepsy characteristics were collected. Read More

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http://doi.wiley.com/10.1111/epi.14601
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http://dx.doi.org/10.1111/epi.14601DOI Listing
January 2019
6 Reads

Late-onset Lennox-Gastaut syndrome: Diagnostic evaluation and outcome.

Neurol Clin Pract 2018 Oct;8(5):397-402

Department of Neurology, Mayo Clinic, Rochester, MN.

Background: We describe the clinical features and outcome in patients with late-onset Lennox-Gastaut syndrome (LGS).

Methods: Adult patients evaluated between January 1, 2000, and March 1, 2017, who presented with onset of LGS ≥10 years were identified. Data abstracted included age at seizure onset, seizure types, etiology, treatments, EEG and neuroimaging results, cerebrospinal fluid (CSF) findings, and autoimmune evaluation. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276343PMC
October 2018
1 Read

Connectivity and Centrality Characteristics of the Epileptogenic Focus Using Directed Network Analysis.

IEEE Trans Neural Syst Rehabil Eng 2019 Jan 11;27(1):22-30. Epub 2018 Dec 11.

Accurate epileptogenic focus localization is required prior to surgical resection of brain tissue for the treatment of patients with antiepileptic drug-resistant (intractable) epilepsy. This clinical need is only partially fulfilled through a subjective, and at times inconclusive, the evaluation of the recorded electroencephalogram (EEG) at seizures' onset (the so-called gold standard for focus localization in epilepsy). We herein present a novel method of multivariate analysis of the EEG that appears to be very promising for an objective and robust localization of the epileptogenic focus at seizures' onset. Read More

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http://dx.doi.org/10.1109/TNSRE.2018.2886211DOI Listing
January 2019
3.188 Impact Factor

encephalopathy: A distinctive generalized developmental and epileptic encephalopathy.

Neurology 2019 Jan 12;92(2):e96-e107. Epub 2018 Dec 12.

From the Epilepsy Research Centre (D.R.M.V., B.J.S., R.B., M.F.B., S.F.B., M.S.H., I.E.S.), Department of Medicine, University of Melbourne, Austin Health, Australia; Departments of Genetics (D.R.M.V., C.M.A.v.R.-A.) and Neurology (D.R.M.V.), University Medical Center Groningen, University of Groningen, the Netherlands; Pediatric Neurology Unit and Laboratories (D.M., M.M.) and Pediatric Neurology (R.G.), Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Italy; Department of Pediatrics and Pediatric Epilepsy Centre (H.X., W.X.W., Y.J.), Peking University First Hospital, Beijing, China; Department of Pediatrics (C.T.M., H.C.M.), Division of Genetic Medicine, University of Washington, Seattle; Population Health and Immunity Division (M.F.B.), Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Medical Biology (M.F.B.), University of Melbourne, Australia; Caulfield (D.W.), Melbourne, Australia; Department of Clinical Genetics (S.M.M.), Academic Medical Centre, Amsterdam, the Netherlands; Department of Clinical Genetics (A.S.B., G.M.S.M., I.M.B.H.v.d.L.), Erasmus University Medical Centre, Rotterdam, the Netherlands; Department of Clinical Genetics (J.M.v.H.), VU University Medical Center, Amsterdam, the Netherlands; Tasmanian Health Service (T.L.W.), Women's and Children's Services, Launceston General Hospital, Tasmania, Australia; TY Nelson Department of Neurology and Neurosurgery (R.I.W.) and Institute of Neuroscience and Muscle Research (R.I.W.), Children's Hospital at Westmead, Sydney, Australia; Department of Neurosciences (S.M.), Lady Cilento Children's Hospital, Brisbane, Australia; Department of Anatomical Pathology (R.M.K.), Austin Hospital, Melbourne, Australia; IRCCS Stella Maris Foundation (F.S., R.G.), Pisa, Italy; Klinikum Oldenburg (G.C.K.), Zentrum für Kinder-und Jugendmedizin, Klinik für Neuropädiatrie u. angeborene Stoffwechselerkrankungen, Oldenburg, Germany; Centre of Epilepsy (Y.J.), Beijing Institute for Brain Disorders, China; Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Australia; and Florey Institute of Neurosciences and Mental Health (I.E.S.), Parkville, Australia.

Objective: To delineate the epileptology, a key part of the phenotypic spectrum, in a large patient cohort.

Methods: Patients were recruited via investigators' practices or social media. We included patients with (likely) pathogenic variants or chromosome 6p21. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340340PMC
January 2019
7 Reads

mutations cause variable phenotypes of developmental and epileptic encephalopathy.

Epilepsia Open 2018 Dec 1;3(4):495-502. Epub 2018 Nov 1.

Department of Pediatrics Showa University School of Medicine Shinagawa-ku, Tokyo Japan.

Objective: Vitamin B-dependent epilepsies are treatable disorders caused by variants in several genes, such as ,, and others. Recently, biallelic variants in formerly known as , were identified as a novel cause of vitamin B-dependent epilepsies. Our objective was to further delineate the phenotype of mutation. Read More

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http://dx.doi.org/10.1002/epi4.12272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276781PMC
December 2018
2 Reads

Unravelling the brain networks driving spike-wave discharges in genetic generalized epilepsy-common patterns and individual differences.

Epilepsia Open 2018 Dec 23;3(4):485-494. Epub 2018 Aug 23.

Department of Neurology and Epileptology Hertie-Institute for Clinical Brain Research University of Tübingen Tübingen Germany.

Objective: Genetic generalized epilepsies (GGEs) are characterized by generalized spike-wave discharges (GSWDs) in electroencephalography (EEG) recordings without underlying structural brain lesions. The origin of the epileptic activity remains unclear, although several studies have reported involvement of thalamus and default mode network (DMN). The aim of the current study was to investigate the networks involved in the generation and temporal evolution of GSWDs to elucidate the origin and propagation of the underlying generalized epileptic activity. Read More

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http://dx.doi.org/10.1002/epi4.12252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276776PMC
December 2018
1 Read

New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

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http://www.cmj.org/text.asp?2018/131/24/2915/247194
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http://dx.doi.org/10.4103/0366-6999.247194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302641PMC
December 2018
11 Reads

The electroclinical features of idiopathic generalized epilepsy patients presenting with fixation-off sensitivity.

Epileptic Disord 2018 Dec;20(6):479-489

Epilepsy and Sleep Disorders Unit, Department of Neurology, The Fourth Military Medical University, Xi'an, 710032, China.

To determine the electroclinical features of fixation-off sensitivity (FOS) in patients with idiopathic generalized epilepsy (IGE). We searched the EEG database using the terms "fixation-off sensitivity" and "idiopathic generalized epilepsy" over a four-year period from March 2014 to April 2018 in the Xijing Hospital, Xi'an, China. FOS was evaluated according to the technique proposed by Panayiotopoulos. Read More

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http://dx.doi.org/10.1684/epd.2018.1021DOI Listing
December 2018
1 Read

De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec;20(6):502-507

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

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http://dx.doi.org/10.1684/epd.2018.1008DOI Listing
December 2018
2 Reads

Intractable apnoeic seizures in a child with a deletion typically associated with Williams syndrome.

Epileptic Disord 2018 Dec;20(6):530-534

Division of Pediatric Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto.

Williams-Beuren syndrome is rarely associated with epilepsy. One previously reported case showed an association with apnoeic seizures while a few other cases showed an association with infantile epileptic spasms and generalized and focal seizures. We report the case of a 13-month-old boy with a deletion typically associated with Williams-Beuren syndrome, who presented with isolated apnoeic seizures which were refractory to multiple antiepileptic drugs but partially responsive to the ketogenic diet. Read More

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http://dx.doi.org/10.1684/epd.2018.1013DOI Listing
December 2018
6 Reads

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence.

Epileptic Disord 2018 Dec;20(6):490-501

Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas' NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK.

The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure. We prospectively studied 150 consecutive adults with a first unprovoked tonic-clonic seizure and full clinical, EEG, and brain imaging assessment within the first four weeks. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1014DOI Listing
December 2018
2 Reads

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec;20(6):457-467

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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http://dx.doi.org/10.1684/epd.2018.1009DOI Listing
December 2018
2 Reads

Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient.

Epileptic Disord 2018 Dec;20(6):557-561

IRCCS Institute of Neurological Sciences, Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

We describe a 68-year-old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure-free periods until seizure control at 59 years of age. After six years of being seizure-free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. Read More

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http://dx.doi.org/10.1684/epd.2018.1016DOI Listing
December 2018

Emotional Reaction to viewing one's own epileptic seizure.

Seizure 2019 Jan 24;64:34-40. Epub 2018 Nov 24.

Epilepsy Center, Freiburg University Medical Center, Germany.

Purpose: If consciousness or memory are impaired during an epileptic seizure, the patient may not experience or know how his/her own seizure looks like. It is disputed, whether being confronted with own seizures may lead to emotional stress or empower patients and decrease negative psychosocial consequences. We assessed patients' reactions to watching a video of their own seizure on measures of anxiety, depression and ten emotions. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.016DOI Listing
January 2019
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Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy.

Can J Neurol Sci 2019 Jan 3;46(1):64-70. Epub 2018 Dec 3.

1Department of Pediatrics, Division of Neurology,BC Children's Hospital,Vancouver, British Columbia,Canada.

Objective: Benign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features. Read More

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http://dx.doi.org/10.1017/cjn.2018.364DOI Listing
January 2019
2 Reads

Efficacy of limited hippocampal radiofrequency thermocoagulation for mesial temporal lobe epilepsy.

J Neurosurg 2018 Oct 1:1-9. Epub 2018 Oct 1.

1Department of Neurosurgery; and.

OBJECTIVERadiofrequency thermocoagulation (RFTC), which has been developed for drug-resistant epilepsy patients, involves less brain tissue loss due to surgery, fewer surgical adverse effects, and generally good seizure control. This study demonstrates the effectiveness of RFTC performed at limited hippocampal locations.METHODSDaily seizure diaries were prospectively maintained for at least 6 months by 9 patients (ages 30-59 years) with drug-resistant mesial temporal lobe epilepsy (MTLE) before treatment with RFTC. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.4.JNS184DOI Listing
October 2018
1 Read
3.737 Impact Factor

Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach.

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

1Department of Neurosurgery, Hofstra Northwell School of Medicine.

ObjectiveDisconnection of the cerebral hemispheres by corpus callosotomy (CC) is an established means to palliate refractory generalized epilepsy. Laser interstitial thermal therapy (LITT) is gaining acceptance as a minimally invasive approach to treating epilepsy, but this method has not been evaluated in clinical series using established methodologies to assess connectivity. The goal in this study was to demonstrate the safety and feasibility of MRI-guided LITT for CC and to assess disconnection by using electrophysiology- and imaging-based methods. Read More

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http://dx.doi.org/10.3171/2018.4.JNS172588DOI Listing
November 2018
16 Reads

Clinical Use and Efficacy of Levetiracetam for Absence Epilepsies.

J Child Neurol 2018 Nov 21:883073818811511. Epub 2018 Nov 21.

2 Division of Pediatric Neurology, Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.

Background:: Levetiracetam is prescribed for a broad spectrum of seizure types but does not have a specific indication for absence epilepsy. We hypothesized that levetiracetam is commonly prescribed for children with absence epilepsies and evaluated the efficacy of this medication for absence epilepsy treatment in clinical practice. We also hypothesized that electroencephalographic (EEG) findings could help predict levetiracetam efficacy. Read More

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http://dx.doi.org/10.1177/0883073818811511DOI Listing
November 2018
10 Reads

Ictal vomiting after cerebellar hemorrhage: A case report.

Epilepsy Behav Case Rep 2018 11;10:137-140. Epub 2018 Sep 11.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Vomiting is a typical symptom of cerebellar hemorrhage. Usually only supportive care such as antiemetic drugs are available. A 76-year-old woman presented in a light coma. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226560PMC
September 2018
1 Read

Neuro-Glial Network Model Of Postictal Generalized EEG Suppression (PGES).

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:2044-2047

Over the past couple of decades, glial cells have been highlighted as active agents in hyperexcitability of neuronal networks, specifically playing key roles in seizure onset and termination. In particular, microglia have been suggested to have both neuroprotective and neurotoxic effects on the brain. Investigation into seizure termination is of particular interest, as it is sometimes followed by a postictal generalized EEG suppression (PGES) - a low activity state that is potentially associated with sudden unexpected death in epilepsy. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512661DOI Listing

What is the interest of the electroencephalogram in the syndromic diagnosis?

Tunis Med 2018 Aug - Sep;96(8-09):528-531

Introduction: The identification of the epileptic syndrome is a challenge particularly in childhood epilepsies. In fact, the diagnosis may need several years to be fulfilled.

Observation: Our patient presented at the age of 3 years 6 months atypical absence. Read More

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November 2018
25 Reads