128,556 results match your criteria Generalized Epilepsies on EEG


The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

University of Saskatchewan, Department of Physiology, Saskatoon, SK, Canada.

Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype closely correlated to that of human absence epilepsies. Similar to the human conditions, GAERS display social abnormalities. Read More

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December 2018

Safety of endoscopy in cancer patients with thrombocytopenia and neutropenia.

Gastrointest Endosc 2018 Dec 11. Epub 2018 Dec 11.

The University of Texas MD Anderson Cancer Center, Department of Gastroenterology, Hepatology and Nutrition. Electronic address:

Background And Aims: Cancer patients are prone to thrombocytopenia and neutropenia, which increase the risk of bleeding and infection. We assessed the safety of endoscopic procedures in cancer patients with thrombocytopenia and/or neutropenia.

Methods: We studied consecutive cancer patients with thrombocytopenia and/or neutropenia who underwent endoscopic procedures from 2010 through 2015. Read More

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December 2018

Grit is associated with lower level of depression and anxiety among university students in Chiang Mai, Thailand: A cross-sectional study.

PLoS One 2018 14;13(12):e0209121. Epub 2018 Dec 14.

Department of Global Health and Socio-epidemiology, Kyoto University School of Public Health, Kyoto, Japan.

Background: Depression and anxiety symptoms are prevalent among university students in both developed and developing settings. Recently, grit, defined as perseverance and passion for long-term goals, has emerged as an indicator of success and well-being. However, the relationship between grit and poor mental health outcomes among university students is largely unknown. Read More

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December 2018
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Ethnic background and children's television viewing trajectories: The Generation R Study.

PLoS One 2018 14;13(12):e0209375. Epub 2018 Dec 14.

Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.

This study, conducted in the Netherlands, evaluated the association between ethnic background and children's TV viewing time at multiple time points and its trajectory. We analyzed 4,833 children with a Dutch, Moroccan, Turkish, or Surinamese ethnic background from the Generation R Study, a population-based study in the Netherlands. Parent-reported television viewing time for children at ages 2, 3, 4, 6, and 9 years was collected by questionnaires sent from April 2004 until January 2015. Read More

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December 2018

Phenology of Trichodesmium spp. blooms in the Great Barrier Reef lagoon, Australia, from the ESA-MERIS 10-year mission.

PLoS One 2018 14;13(12):e0208010. Epub 2018 Dec 14.

Commonwealth Scientific and Industrial Research Organization (CSIRO), Canberra, Australia.

Trichodesmium, a filamentous bloom-forming marine cyanobacterium, plays a key role in the biogeochemistry of oligotrophic ocean regions because of the ability to fix nitrogen. Naturally occurring in the Great Barrier Reef (GBR), the contribution of Trichodesmium to the nutrient budget may be of the same order as that entering the system via catchment runoff. However, the cyclicity of Trichodesmium in the GBR is poorly understood and sparsely documented because of the lack of sufficient observations. Read More

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December 2018

Generalized Periodic Discharges With and Without Triphasic Morphology.

J Clin Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Comprehensive Epilepsy Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A.

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December 2018

[The clinical laboratory characteristic of primary acute cytomegalovirus infection in non-immunocompromised adult patients].

Klin Lab Diagn 2018 ;63(1):51-54

The state budget institution of health care "The clinical center of prevention and struggle with AIDS" of the Minzdrav of the Krasnodar kraii, 350015, Krasnodar, Russia.

The purpose of study is the clinical laboratory characteristic of acquired acute cytomegalovirus infection in nonimmunocompromised adult patients. The sampling included 75 patients with acquired acute cytomegalovirus infection admitted to the specialized clinical infection hospital of the Minzdrav of the Krasnodar kraii. The verifcation of diagnosis was implemented using serological tests and polymerase chain reaction. Read More

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January 2018

Ambulatory Care Sensitive Admissions in Individuals With Autism Spectrum Disorder, Intellectual Disability, and Population Controls.

Autism Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.

Ambulatory care sensitive (ACS) admissions are those for which effective primary care can prevent the need for emergency department (ED) visits and inpatient hospitalizations, and are an indicator of primary care access. Individuals with autism spectrum disorder (ASD) and/or intellectual disability (ID) may be at higher risk for ACS admissions than individuals in the general population due to difficulty accessing primary care. The objective of this study was to compare the incidence of ACS admissions among four cohorts of individuals aged 2-24 years: ASD without co-occurring ID (ASD-only), ASD with co-occurring ID (ASD + ID), ID without ASD (ID-only), and population controls (PC). Read More

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December 2018

Longitudinal change in the cerebroplacental ratio and the risk of stillbirth.

Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK Cranmer Terrace, London, SW17 0RE.

Objectives: To investigate whether the longitudinal Doppler changes in small-for-gestational age (SGA) fetuses improves the prediction of those at risk of intrauterine fetal death (IUFD).

Methods: A longitudinal study using two cohorts of singleton pregnancies (SGA and appropriate for gestational age [AGA]). The inclusion criteria for the SGA cohort were singleton pregnancies at 20 weeks' gestation or beyond and diagnosed with SGA. Read More

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December 2018

Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Pustulotic arthro-osteitis, occasionally complicated with palmoplantar pustulosis, affects patients' activities of daily living. Granulocyte and monocyte adsorption apheresis selectively removes activated granulocytes and monocytes by means of extracorporeal circulation. Although the efficacy of granulocyte and monocyte adsorption apheresis in the treatment of generalized pustular psoriasis has been proved, very few reports have assessed its efficacy in the treatment of palmoplantar pustulosis and pustulotic arthro-osteitis. Read More

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December 2018
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Hydrogenation of 3d-Metal Oxide Clusters: Effects on the Structure and Magnetic Properties.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region, Russia.

The geometrical structures and properties of the M O , M O H , and M O H clusters are explored using density functional theory with the generalized gradient approximation for all 3d-metals M from Sc to Zn. It is found that the geometries and total spin magnetic moments of the clusters depended strongly on the 3d-atom type and the hydrogenation extent. More than the half of all of the 30 clusters had singlet lowest total energy states, which could be described as either nonmagnetic or antiferromagnetic. Read More

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December 2018

DiTe2: Calculating the diffusion tensor for flexible molecules.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Sciences, University of Padua, Padova 35131, Italy.

We report on an extended hydrodynamic modeling of the friction tensorial properties of flexible molecules including all types of natural, Z-Matrix like, internal coordinates. We implement the new methodology by extending and updating the software DiTe [Barone et al. J. Read More

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December 2018

Evaluating small-scale simulation for training firearm safety skills.

J Appl Behav Anal 2018 Dec 14. Epub 2018 Dec 14.

University of South Florida.

There is limited research using small-scale simulation in applied behavior analysis. We used small-scale simulation to train firearm safety skills to 3- to 5-year-old children and assessed whether the skills generalized to the natural environment through in situ assessment. Three participants completed the training, and all participants learned the safety skills from simulation training. Read More

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December 2018

Geographical adaptation prevails over species-specific determinism in trees' vulnerability to climate change at Mediterranean rear-edge forests.

Glob Chang Biol 2018 Dec 13. Epub 2018 Dec 13.

Ecoclimatology, Department of Ecology and Ecosystem Management, Technische Universität München, Freising, Germany.

Climate change may reduce forest growth and increase forest mortality, which is connected to high carbon costs through reductions in gross primary production and net ecosystem exchange. Yet the spatiotemporal patterns of vulnerability to both short-term extreme events as well as gradual environmental changes are quite uncertain across the species' limits of tolerance to dryness. Such information is fundamental for defining ecologically relevant upper limits of species tolerance to drought and hence, to predict the risk of increased forest mortality and shifts in species composition. Read More

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December 2018

Well-Defined Metal Nanoparticles@Covalent Organic Framework Yolk-Shell Nanocages by ZIF-8 Template as Catalytic Nanoreactors.

Small 2018 Dec 13:e1804419. Epub 2018 Dec 13.

College of Materials Science and Engineering, Fuzhou University, New Campus, Minhou, Fujian, 350108, China.

Yolk-shell nanoreactors have received considerable interest for use in catalysis. However, the controlled synthesis of continuous crystalline shells without imperfections or cracks remains challenging. Here, a strategy for the synthesis of yolk-shell metal nanoparticles@covalent organic framework (MNPs@COF) nanoreactors by using MNPs@ZIF-8 core-shell nanostructures as a self-template is designed and developed. Read More

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December 2018

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract-based automatic analysis.

Autism Res 2018 Dec 12. Epub 2018 Dec 12.

Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.

Investigating social behaviors and brain structural alterations in unaffected siblings of individuals with autism spectrum disorder (ASD) may help identify intermediate phenotypes of social communication deficits in ASD. This study hypothesized that such intermediate phenotypes could be identified in white matter tracts of the social communication model that exhibited reduced tract integrity and associations with social communication deficits. Boys with ASD (N = 30), unaffected male siblings (N = 27), and typically developing (TD) boys (N = 30) underwent clinical evaluation and MRI scanning. Read More

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December 2018

Generalized Model of the Linear Theory of Electromigration and its Application to Electrokinetic Chromatography: Theory and Software PeakMaster 6 - Next Generation.

Electrophoresis 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Science, Department of Physical and Macromolecular Chemistry, Charles University in Prague, Prague, Czech Republic.

The linear theory of electromigration, including the first-order nonlinear approximation, is generalized to systems with any equilibria fast enough to be considered instantaneous in comparison with the time-scale of peak movement. For example, this theory is practically applied in the electrokinetic chromatography (EKC) mode of the capillary zone electrophoresis. The model enables the calculation of positions and shapes of analyte and system peaks without restricting the number of selectors, the complexation stoichiometry, or simultaneous acid-base equilibria. Read More

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December 2018

Getting into shape: Limb bone strength in perinatal Lemur catta and Propithecus coquereli.

Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.

School of Physical Therapy, Slippery Rock University, Slippery Rock, PA, 16057.

Functional studies of skeletal anatomy are predicated on the fundamental assumption that form will follow function. For instance, previous studies have shown that the femora of specialized leaping primates are more robust than those of more generalized primate quadrupeds. Are such differences solely a plastic response to differential loading patterns during postnatal life, or might they also reflect more canalized developmental mechanisms present at birth? Here, we show that perinatal Lemur catta, an arboreal/terrestrial quadruped, have absolutely and relatively weaker femora than perinatal Propithecus coquereli, a closely-related species specialized for vertical clinging and leaping (a highly unusual locomotor mode in which the hindlimbs are used to launch the animal between vertical tree trunks). Read More

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December 2018

Interaction of membrane palmitoylated protein-1 with model lipid membranes.

Gen Physiol Biophys 2018 Sep;37(6):603-617

Department of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, 50-383 Wrocław, Poland.

Membrane palmitoylated protein-1 (MPP1) plays an important role in the formation of raft domains in erythroid membranes. We have shown recently that MPP1 interacts with membrane lipids composed of dioleoylphosphatidylcholine (DOPC), sphingomyelin (SM) and cholesterol. Here we further extend this investigation. Read More

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September 2018

Lipid levels, insulin resistance and cardiovascular risk over 96 weeks of antiretroviral therapy: a randomised controlled trial comparing low-dose stavudine and tenofovir.

Retrovirology 2018 Dec 14;15(1):77. Epub 2018 Dec 14.

Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Background: HIV infection and antiretroviral treatment are associated with changes in lipid levels, insulin resistance and risk of cardiovascular disease (CVD). We investigated these changes in the first 96 weeks of treatment with low-dose stavudine or tenofovir regimens.

Methods: This is a secondary analysis of a double blind, randomised controlled trial performed in South-Africa, Uganda and India comparing low-dose stavudine (20 mg twice daily) with tenofovir in combination with efavirenz and lamivudine in antiretroviral-naïve adults (n = 1067) (Clinicaltrials. Read More

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December 2018

Brucellosis in the Addis Ababa dairy cattle: the myths and the realities.

BMC Vet Res 2018 Dec 14;14(1):396. Epub 2018 Dec 14.

Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.

Background: Bovine brucellosis is considered as an important disease among livestock and people in sub-Saharan African countries including Ethiopia. A cross-sectional study was conducted from November 2016 to May 2017 to estimate the prevalence and associated risk factors, and to assess knowledge-attitude and practices (KAP) of farm workers about bovine brucellosis in Addis Ababa dairy farms.

Results: A total of 1550 cattle from 127 dairy farms were serially tested using the Rose Bengal Plate Test (RBPT), Competitive Enzyme-Linked Immunosorbant Assay (c-ELISA) and Complement Fixation Test (CFT). Read More

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December 2018

Increased hepatitis C virus co-infection and injection drug use in HIV-infected fishermen in Myanmar.

BMC Infect Dis 2018 Dec 14;18(1):657. Epub 2018 Dec 14.

MSF, Geneva, Switzerland.

Background: In Southeast Asia, though fishermen are known to be a key population at high risk of HIV, little is known about their co-infection rates with Hepatitis C virus (HCV), or how illness and risk behaviors vary by occupation or type of fishermen. In Myanmar, this lack of knowledge is particularly acute, despite the fact that much of the country's border is coastline.

Methods: We conducted a retrospective analysis to assess clinical, demographic, and risk characteristics of HIV-infected, ≥15-year-old males under HIV care from 2004 to 2014. Read More

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December 2018

Principal Chiral Model in Correlated Electron Systems.

Phys Rev Lett 2018 Nov;121(22):227201

Department of Physics and Astronomy, The University of Tennessee, Knoxville, Tennessee 37996, USA.

We discuss noncollinear magnetic phenomena whose local order parameter is characterized by more than one spin vector. By focusing on the simple cases of 2D triangular and 3D pyrochlore lattices, we demonstrate that their low-energy theories can be described by a one-parametric class of sigma models continuously interpolating between the classical Heisenberg model and the principal chiral model Tr(∂_{a}U∂_{a}U^{†}) for all U∈SU(2). The target space can be viewed as a U(1) fibration over the CP(1) space. Read More

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November 2018

Sweet's syndrome as a dermatological manifestation of underlying coronary artery disease.

J Cardiol Cases 2012 Jul 10;6(1):e8-e12. Epub 2012 Apr 10.

Department of Pathology, Hurley Medical Center, Flint, MI, USA.

We report an unusual case of a 50-year-old female with no significant past medical history who reported with a sudden eruption of painful erythematous papules accompanied by fever. Clinical and pathological findings were consistent with acute febrile neutrophilic dermatosis (or Sweet's syndrome). Two weeks later, she complained of chest pain and was diagnosed with non-ST elevation myocardial infarction. Read More

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"Approximate number system" training: A perceptual learning approach.

Atten Percept Psychophys 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Wisconsin-Madison, 1202 W. Johnson St., Madison, WI, 53706, USA.

Recent research suggests that humans perceive quantity using a non-symbolic "number sense." This sense is then thought to provide a foundation for understanding symbolic numbers in formal education. Given this link, there has been interest in the extent to which the approximate number system (ANS) can be improved via dedicated training, as this could provide a route to improving performance in symbolic mathematics. Read More

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December 2018

Insomnia and cardiorespiratory fitness in a middle-aged population: the SCAPIS pilot study.

Sleep Breath 2018 Dec 13. Epub 2018 Dec 13.

Center for Sleep and Vigilance Disorders, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 8b, Box 421, SE-40530, Gothenburg, Sweden.

Background: The relationship between insomnia and cardiorespiratory fitness (CRF), a well-established risk factor for cardiovascular disease, has not been extensively studied. We aimed to assess the independent association between insomnia and CRF in a population-based cohort of subjects aged 50 to 64 years.

Methods: Subjects participating in the Swedish CArdioPulmonary bioImaging Study (SCAPIS) pilot cohort (n = 603, men 47. Read More

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December 2018
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Public housing and healthcare use: an investigation using linked administrative data.

Can J Public Health 2018 Dec 13. Epub 2018 Dec 13.

Department of Community Health Sciences, University of Manitoba, S113-750 Bannatyne Ave, Winnipeg, Manitoba, R3E 0W3, Canada.

Objective: This study investigated whether a move to public housing affects people's use of healthcare services.

Method: Using administrative data from Manitoba, the number of hospitalizations, general practitioner (GP), specialist and emergency department (ED) visits, and prescription drugs dispensed in the years before and after the housing move-in date (2012/2013) were measured for a public housing and matched cohort. Generalized linear models with generalized estimating equations tested for differences between the cohorts in utilization trends. Read More

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December 2018

Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes.

EJNMMI Res 2018 Dec 13;8(1):110. Epub 2018 Dec 13.

Department of Nuclear Medicine and Molecular Imaging, Division of Nuclear Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an early stage. The objective of this study was to classify patients with amyotrophic lateral sclerosis (ALS) and Parkinson plus syndromes (PP). To this end, different approaches were evaluated using generalized linear models and corresponding glucose metabolic brain patterns. Read More

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December 2018

Relationship Between Thyroid Hormone Levels and Mean Platelet Count and Volume: Quantitative Assessment.

Cureus 2018 Oct 8;10(10):e3421. Epub 2018 Oct 8.

Internal Medicine, Virginia Commonwealth University, Richmond, USA.

Background The hormones of the hypophysis-thyroid axis (HTA), thyroid stimulating hormone (TSH), and thyroid hormones, L-thyroxine (T4) and 3, 3', 5-L-triiodothyronine (T3), modulate the metabolism, differentiation, and proliferation of almost every cell in the body. Several studies have examined the effect of HTA hormones on platelet count and mean platelet volume (MPV), but have reported inconsistent results. Our aim was to examine the association between HTA hormones and platelet count and MPV in a large cohort of the adult population of the United States. Read More

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October 2018
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Estimating PM speciation concentrations using prototype 4.4 km-resolution MISR aerosol properties over Southern California.

Atmos Environ (1994) 2018 May 10;181:70-81. Epub 2018 Mar 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.

Research efforts to better characterize the differential toxicity of PM (particles with aerodynamic diameters less than or equal to 2.5 μm) speciation are often hindered by the sparse or non-existent coverage of ground monitors. The Multi-angle Imaging SpectroRadiometer (MISR) aboard NASA's Terra satellite is one of few satellite aerosol sensors providing information of aerosol shape, size and extinction globally for a long and continuous period that can be used to estimate PM speciation concentrations since year 2000. Read More

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Preconception insurance and initiation of prenatal care.

J Perinatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.

Objective: The primary objective was to determine the association between preconception insurance and initiation of prenatal care.

Study Design: This retrospective cohort uses data from the Pregnancy Risk Assessment Monitoring System (2009-2013). Self-reported preconception insurance status was the primary exposure. Read More

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December 2018

Using Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial.

JMIR Ment Health 2018 Dec 13;5(4):e64. Epub 2018 Dec 13.

X2AI Inc, San Francisco, CA, United States.

Background: Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less-intensive and more cost-effective alternative for treating depression and anxiety. Although CBT is one of the most effective treatment methods, applying an integrative approach has been linked to equally effective posttreatment improvement. Read More

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December 2018
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Experimental sensorless control for a coupled two-tank system using high gain adaptive observer and nonlinear generalized predictive strategy.

ISA Trans 2018 Dec 4. Epub 2018 Dec 4.

Research Unit of Industrial Systems Study and Renewable Energy (ESIER), National Engineering School of Monastir (ENIM), Ibn El Jazzar, 5019, Monastir, University of Monastir, Tunisia. Electronic address:

In this paper an adaptive control for a coupled two-tank system is proposed. This control strategy uses a generalized predictive controller, whose main method is to minimize a multistage cost function defined over a prediction horizon. Furthermore, to implement this controller in the framework of the sensorless control from the only measurement of the liquid level in the bottom tank, an adaptive interconnected high gain observer is developed for estimating the liquid level in the upper tank and the two constant parameters of the system. Read More

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December 2018

Comprehensive Intra-Institution stepping validation of knowledge-based models for automatic plan optimization.

Phys Med 2018 Dec 10. Epub 2018 Dec 10.

Medical Physics, San Raffaele Scientific Institute, Milano, Italy.

Purpose: To develop and apply a stepping approach for the validation of Knowledge-based (KB) models for planning optimization: the method was applied to the case of concomitant irradiation of pelvic nodes and prostate + seminal-vesicles bed irradiation in post-prostatectomy patients.

Methods: The clinical VMAT plans of 52 patients optimized by two reference planners were selected to generate a KB-model (RapidPlan, v.13. Read More

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December 2018

Lower Optimal Treatment Adherence Among Youth Living With HIV in a Universal Health Care Setting Where ART Is Available at No Cost.

J Adolesc Health 2018 Nov 28. Epub 2018 Nov 28.

The British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Barnaby, British Columbia, Canada. Electronic address:

Purpose: We assessed differences in optimal adherence between youth (aged 15-29 years) and adults (aged ≥30 years) enrolled in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program from 2010 to 2016.

Methods: Population-level clinical data were used to compare optimal antiretroviral therapy adherence (≥95%), based on pharmacy refill data, among youth and adults. Unadjusted and adjusted generalized estimating estimates were performed to examine the independent relationship between time-dependent age categories and optimal adherence, adjusting for confounders. Read More

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November 2018

Longitudinal Trends in the Diagnosis of Attention-Deficit/Hyperactivity Disorder and Stimulant Use in Preschool Children on Medicaid.

J Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Kentucky Department of Medicaid Services, Frankfort, KY, USA.

Objectives: To describe trends in the diagnosis of attention-deficit/hyperactivity disorder (ADHD) and prescribing of stimulants in preschool-age children receiving Medicaid and to identify factors associated with the receipt of psychosocial care.

Study Design: Data were extracted from 2012-2016 Kentucky Medicaid claims for children aged <6 years. ADHD was identified using International Classification of Diseases, Tenth Revision codes F90. Read More

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December 2018

Calprotectin strongly and independently predicts relapse in rheumatoid arthritis and polyarticular psoriatic arthritis patients treated with tumor necrosis factor inhibitors: a 1-year prospective cohort study.

Arthritis Res Ther 2018 Dec 13;20(1):275. Epub 2018 Dec 13.

Department of Rheumatology, Hospital Clinic, University of Barcelona, Carrer Villarroel 170, 08036, Barcelona, Spain.

Background: Calprotectin is a biomarker of disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and predicts relapse in juvenile idiopathic arthritis. Higher drug trough serum levels are associated with a good response in patients treated with tumor necrosis factor inhibitors (TNFi). Power Doppler ultrasound synovitis is predictive of relapse and structural damage progression in patients in clinical remission. Read More

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December 2018
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Association between Hemoglobin and Hemoglobin A: A Data-Driven Analysis of Health Checkup Data in Japan.

J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan.

Background: Interpretation of hemoglobin A (HbA) levels may be confounded by spurious results in anemic persons, but its degree is not well-established.

Methods: We used an employer-based health insurance database, containing health checkup data and medical claims data; both were linked via a unique identifier of each beneficiary. This study included persons aged 18⁻75 years who participated in health checkups, with a confirmed or suspected diagnosis of diabetes. Read More

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December 2018

Frequency of Dietary Intake and Physical Activity in Older Adults: A Cross-Sectional Study.

Nutrients 2018 Dec 11;10(12). Epub 2018 Dec 11.

General Medical Hospital 'Sveti Duh', 10 000 Zagreb, Croatia.

Background: Evidence shows that diet is associated with physical activity. However, there has been a lack of studies addressing it in a population of older adults. Therefore, the main purpose of this study was to explore associations between various frequencies of dietary intake and physical activity in older adults. Read More

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December 2018
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Combining a QSAR Approach and Structural Analysis to Derive an SAR Map of Lyn Kinase Inhibition.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660⁻Hay Moulay Rachid, 43150 Ben-Guerir, Morocco.

Lyn kinase, a member of the Src family of protein tyrosine kinases, is mainly expressed by various hematopoietic cells, neural and adipose tissues. Abnormal Lyn kinase regulation causes various diseases such as cancers. Thus, Lyn represents, a potential target to develop new antitumor drugs. Read More

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December 2018

Asymmetric pattern in generalized myasthenia gravis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13460

Federal University of Rio de Janeiro.

Rationale: Myasthenia gravis (MG) is an uncommon autoimmune disease mediated by antibodies that attack the postsynaptic acetylcholine receptors (AchRs) at the neuromuscular junction, causing fluctuating muscle weakness, aggravated with use, and relieved with rest.

Patient Concerns: A 32-year-old woman with a diagnosis of MG based on clinical findings, eletroneuromyography, and brain magnetic resonance imaging (MRI) was admitted to our hospital with dysphagia, dysphonia, diplopia, and intense weakness, associated with a 2-day viral gastroenteritis.

Diagnoses: Physical examination revealed globally reduced deep tendon reflexes, and tetraparesis, with muscle strength grade 4 in the left limbs and grade 2 in the right limbs. Read More

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December 2018

Targeted next-generation sequencing identifies a novel mutation of LAMB3 in a Chinese neonatal patient presented with junctional epidermolysis bullosa.

Medicine (Baltimore) 2018 Dec;97(49):e13225

Department of Obstetrics and Gynecology, Wuhan Medical & Health Center for Women and Children, Wuhan, Hubei.

Rationale: Epidermolysis bullosa (EB) refers to a group of rare inherited mechanobullous disorders that present with great clinical and genetic heterogeneity. Its severity ranges from mild blistering to life-threatening. However, the clinical symptoms of different types of EB overlap significantly, especially at an early stage. Read More

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December 2018

Robot-assisted stereoelectroencephalography in children.

Authors:

J Neurosurg Pediatr 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEThe goal in the study was to describe the clinical outcomes associated with robot-assisted stereoelectroencephalography (SEEG) in children.METHODSThe authors performed a retrospective, single-center study in consecutive children with medically refractory epilepsy who were undergoing robot-assisted SEEG. Kaplan-Meier survival analysis was used to calculate the probability of seizure freedom. Read More

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December 2018

Mean and variance of greenness and pregnancy outcomes in Tel Aviv during 2000-14: longitudinal and cross-sectional approaches.

Int J Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Ministry of Health, Jerusalem, Israel.

Background: Natural environments may have beneficial impacts on pregnancy outcomes. However, longitudinal evidence is limited and the associations with variance in surrounding greenness is unknown. Our objective was to evaluate these associations among 73 221 live births in Tel Aviv, Israel. Read More

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December 2018

The short-term association between air pollution and childhood asthma hospital admissions in urban areas of Hefei City in China: A time-series study.

Environ Res 2018 Dec 1;169:510-516. Epub 2018 Dec 1.

Anhui Province Key Laboratory of Major Autoimmune Diseases, Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:

Background: The impacts of air pollution on asthma attacks have become a hotspot. Previous studies mainly focused on the developed countries or cities. There have been very limited studies in less-developed region to quantify the effects of air pollutants on asthma admissions in children. Read More

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December 2018

Short-term PM and emergency department admissions for selective cardiovascular and respiratory diseases in Beijing, China.

Sci Total Environ 2018 Dec 6;657:213-221. Epub 2018 Dec 6.

Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. Electronic address:

Background: Few studies have explored PM's connection with specific respiratory and cardiovascular emergency department admissions (EDAs). This study aimed to examine the overall effects of PM on EDAs for cardiovascular and respiratory diseases, including specifically, cerebrovascular events (CVE), ischemic heart disease (IHD), arrhythmia, heart failure (HF), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), chronic obstructive pulmonary disease (COPD) and asthma.

Methods: We collected daily data for EDAs from the 10 largest hospitals in Beijing, between January 2013 and December 2013 as well as daily measurements of PM from 17 stations in Beijing. Read More

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December 2018

A systematic review on the therapeutic effectiveness of non-invasive brain stimulation for the treatment of anxiety disorders.

Neurosci Biobehav Rev 2018 Dec 10. Epub 2018 Dec 10.

Dept. Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany; Dept. Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany.

The interest in the use of non-invasive brain stimulation for enhancing neural functions and reducing symptoms in anxiety disorders is growing. Based on the DSM-V classification for anxiety disorders, we examined all available research using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) for the treatment of specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalized anxiety disorder. A systematic literature search conducted in PubMed and Google Scholar databases provided 26 results: 12 sham-controlled studies and 15 not sham-controlled studies. Read More

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December 2018

Efficacy of participation-focused therapy on performance of physical activity participation goals and habitual physical activity in children with cerebral palsy: a randomized controlled trial.

Arch Phys Med Rehabil 2018 Dec 10. Epub 2018 Dec 10.

Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Objective: To determine the efficacy of a participation-focused therapy (ParticiPAte CP) on leisure-time physical activity goal performance and satisfaction and habitual physical activity (HPA) in children with cerebral palsy (CP).

Design: Randomized waitlist-controlled trial.

Setting: Home and community. Read More

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December 2018

Coherent chaos in a recurrent neural network with structured connectivity.

PLoS Comput Biol 2018 Dec 13;14(12):e1006309. Epub 2018 Dec 13.

Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.

We present a simple model for coherent, spatially correlated chaos in a recurrent neural network. Networks of randomly connected neurons exhibit chaotic fluctuations and have been studied as a model for capturing the temporal variability of cortical activity. The dynamics generated by such networks, however, are spatially uncorrelated and do not generate coherent fluctuations, which are commonly observed across spatial scales of the neocortex. Read More

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December 2018

Polyneuropathy, Myocardial Dysfunction and Pericardial Effusion Following Duodenal Switch.

Acta Medica (Hradec Kralove) 2018 ;61(3):111-113

Department of Medicine E, Sheba Medical Center, Tel-Hashomer affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel.

Duodenal Switch procedure is a type of bariatric surgery that was reserved for severely morbid obese people. Patients undergoing this procedure are at high risk for nutrient deficiencies. In this report we present a case of a patient who had developed polyneuropathy, generalized muscle weakness, Wernicke encephalopathy, myocardial dysfunction and pericardial effusion six years following this operation. Read More

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January 2018