11,101 results match your criteria Generalized Epilepsies on EEG

Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome.

Orphanet J Rare Dis 2022 Jun 25;17(1):248. Epub 2022 Jun 25.

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Philadelphia, PA, 19140, USA.

Background: Hyperinsulinism hyperammonemia (HI/HA) syndrome is caused by activating mutations in GLUD1, encoding glutamate dehydrogenase (GDH). Atypical absence seizures and neuropsychological disorders occur at high rates in this form of hyperinsulinism. Dysregulated central nervous system (CNS) glutamate balance, due to GDH overactivity in the brain, has been hypothesized to play a role. Read More

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Changes of oxygen saturation in patients with pure temporal lobe epilepsy.

Seizure 2022 Jun 16;100:30-35. Epub 2022 Jun 16.

Hacettepe University Medicine Faculty, Department of Neurology, Ankara, Turkey. Electronic address:

Purpose: Ictal hypoxemia is accepted as one of the mechanisms underlying sudden unexpected death in epilepsy (SUDEP). Although ictal hypoxemia is more common in generalized seizures, it also occurs in focal seizures with or without generalization. In this study, we aimed to show the relationship between clinical and electroencephalographic findings of seizures in patients with temporal lobe epilepsy (TLE) with periictal oxygen saturation. Read More

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EEG correlates of quality of life and associations with seizure without awareness and depression in patients with epilepsy.

Neuropsychopharmacol Rep 2022 Jun 20. Epub 2022 Jun 20.

Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Aims: Quality of life (QOL) is an important issue for not only patients with epilepsy but also physicians. Depression has a large impact on QOL. Nonlinear electroencephalogram (EEG) analysis using machine learning (ML) has the potential to improve the accuracy of the diagnosis of epilepsy. Read More

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Case Report: Neurodevelopmental Outcome in a Small-for-Gestational-Age Infant With Symptomatic Hyperinsulinemic Hypoglycemia, Gaze Preference, and Infantile Spasms.

Front Endocrinol (Lausanne) 2022 3;13:818252. Epub 2022 Jun 3.

Pediatric Academic Clinical Programme, Lee Kong Chian School of Medicine, Singapore, Singapore.

Recurrent and profound hypoglycemia is a leading cause of neonatal brain injury. Small-for-gestational-age infants are at risk of hypoglycemia due to substrate deficiency and hyperinsulinism. Inappropriate insulin secretion by the β-cells of the pancreas results in hypoglycemia, neuronal energy deprivation, and parieto-occipital brain injury. Read More

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Neurosurgery in canine epilepsy.

Vet J 2022 Jun 16:105852. Epub 2022 Jun 16.

Laboratory of Veterinary Neurology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.

Epilepsy surgery is functional neurosurgery applied to drug-resistant epilepsy. Although epilepsy surgery has been established and achieves fair to good outcomes in human medicine, it is still an underdeveloped area in veterinary medicine. With the spread of advanced imaging and neurosurgical modalities, intracranial surgery has become commonplace in the veterinary field, and, therefore, it is natural that expectations for epilepsy surgery increase. Read More

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Analysis of clinical phenotypic and genotypic spectra in 36 children patients with Epilepsy of Infancy with Migrating Focal Seizures.

Sci Rep 2022 Jun 17;12(1):10187. Epub 2022 Jun 17.

Department of Neurology, Hunan Children's Hospital, Ziyuan Road 86th, Changsha, 410007, Hunan, People's Republic of China.

Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) is a rare developmental and epileptic encephalopathy (DEEs) with unknown etiology, and poor prognosis. In order to explore new genetic etiology of EIMFS and new precision medicine treatment strategies, 36 children with EIMFS were enrolled in this study. 17/36 cases had causative variants across 11 genes, including 6 novel EIMFS genes: PCDH19, ALDH7A1, DOCK6, PRRT2, ALG1 and ATP7A. Read More

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Interictal Discharge Pattern in Preschool-Aged Children With Tuberous Sclerosis Complex Before and After Resective Epilepsy Surgery.

Front Neurol 2022 31;13:868633. Epub 2022 May 31.

Functional Neurosurgery Department, National Children's Health Center of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Objective: To analyze the interictal discharge (IID) patterns on pre-operative scalp electroencephalogram (EEG) and compare the changes in IID patterns after removal of epileptogenic tubers in preschool children with tuberous sclerosis complex (TSC)-related epilepsy.

Methods: Thirty-five preschool children who underwent resective surgery for TSC-related epilepsy were enrolled retrospectively, and their EEG data collected before surgery to 3 years after surgery were analyzed.

Results: Twenty-three (65. Read More

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Genetic generalized epilepsy and generalized onset seizures with focal evolution (GOFE).

Epilepsy Behav Rep 2022 30;19:100555. Epub 2022 May 30.

Epilepsy Unit "Françis Rohmer", French Reference Center of Rare Epilepsies CREER, FHU, Neurology Department, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

"Generalized Onset with Focal Evolution" (GOFE) is an underrecognized seizure type defined by an evolution from generalized onset to focal activity during the same ictal event. We aimed to discuss electroclinical aspects of GOFE and to emphasize its link with Genetic Generalized Epilepsy (GGE). Patients were identified retrospectively over 10 years, using the video-EEG data base from the Epilepsy Unit of Strasbourg University Hospital. Read More

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Abnormal heart rate variability during non-REM sleep and postictal generalized EEG suppression in focal epilepsy.

Clin Neurophysiol 2022 May 27;140:40-44. Epub 2022 May 27.

Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Objective: To identify any relationship between abnormal interictal heart rate variability (HRV) during sleep and the occurrence of postictal generalized EEG suppression (PGES), a potential biomarker of sudden unexpected death in epilepsy (SUDEP), in patients with focal epilepsy.

Methods: We retrospectively reviewed 34 consecutive patients with focal epilepsy, who presented with focal to bilateral tonic-clonic seizures (FBTCSs), 19 with PGES (PGES+) and 15 without PGES (PGES-), and 14 patients without epilepsy as controls. HRV spectrum analysis was performed for periods of 10 minutes during wakefulness, non-REM sleep, and REM sleep. Read More

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The Prospects of Non-EEG Seizure Detection Devices in Dogs.

Front Vet Sci 2022 23;9:896030. Epub 2022 May 23.

Neurology and Neurosurgery Service, The School of Veterinary Medicine, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

The unpredictable nature of seizures is challenging for caregivers of epileptic dogs, which calls the need for other management strategies such as seizure detection devices. Seizure detection devices are systems that rely on non-electroencephalographic (non-EEG) ictal changes, designed to detect seizures. The aim for its use in dogs would be to provide owners with a more complete history of their dog's seizures and to help install prompt (and potentially life-saving) intervention. Read More

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A Comprehensive and Advanced Mouse Model of Post-Traumatic Epilepsy with Robust Spontaneous Recurrent Seizures.

Curr Protoc 2022 Jun;2(6):e447

Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.

Traumatic brain injury (TBI) is a leading cause of epilepsy in military persons and civilians. Spontaneous recurrent seizures (SRSs) occur in the months or years following the injury, which is commonly referred to as post-traumatic epilepsy (PTE). Currently, there is no effective treatment or cure for PTE; therefore, there is a critical need to develop animal models to help further understand and assess mechanisms and interventions related to TBI-induced epilepsy. Read More

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Childhood absence epilepsy: Electro-clinical manifestations, treatment options, and outcome in a tertiary educational center.

Int J Pediatr Adolesc Med 2022 Jun 26;9(2):131-135. Epub 2021 Nov 26.

Division of Pediatric Neurology, Department of Pediatrics, King Saud University Medical City, Riyadh, Saudi Arabia.

Purpose And Background: To evaluate the electro-clinical manifestations and outcomes of children with absence epilepsy at a tertiary center in Saudi Arabia.

Methods: This retrospective study reviewed the medical and EEG records of patients who were diagnosed to have CAE as per the International League Against Epilepsy (ILAE) definition for CAE. The study was conducted in the pediatric neurology clinic of King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia, between January 2000 and December 2019. Read More

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[Developmental and epileptic encephalopathy 85 caused by SMC1A gene truncating variation: 4 cases report and literature review].

Zhonghua Er Ke Za Zhi 2022 Jun;60(6):583-587

Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, China.

To summarize the clinical phenotype of patients with developmental and epileptic encephalopathy 85 caused by SMC1A gene truncating variation. The clinical data of 4 patients with epileptic encephalopathy caused by SMC1A gene truncating variation from August 2016 to June 2020 were analyzed retrospectively. Related literatures up to October 2021 with the key words "SMC1A" "Developmental and epileptic encephalopathy 85" "SMC1A, epilepsy" and "SMC1A, truncating" in PubMed, CNKI, and Wanfang databases were searched. Read More

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[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].

Y Ju T Y Ji

Zhonghua Er Ke Za Zhi 2022 Jun;60(6):578-582

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize and investigate the clinical characters of epilepsy in children with Mowat-Wilson syndrome (MWS), thus to improve the understanding of this disease. Clinical characters of epilepsy episodes in 5 children with MWS admitted to Department of Pediatrics, Peking University First Hospital from June to December 2020 were retrospectively reviewed. Clinical data including onset age of seizures, clinical features, characters of electroencephalogram (EEG), magnetic resonance imaging (MRI) findings, results of ZEB2 gene testing and responses to the anti-seizure medications (ASM) were summarized. Read More

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VNS parameters for clinical response in Epilepsy.

Brain Stimul 2022 May-Jun;15(3):814-821. Epub 2022 May 25.

Institute of Neuroscience, Université Catholique de Louvain (UCLouvain), Brussels, Belgium; Centre for Refractory Epilepsy, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Background: While vagus nerve stimulation (VNS) has been in use for over two decades, little professional guidance exists to describe dosing and titration of therapy which is the consequence of a limited amount of evidence developed during the pre-market phase of therapy development. Post-market surveillance of dosing practice has revealed significant deviations from dosing and titration guidance offered by professional societies as well as the manufacturer.

Objective: This analysis aims to identify a target dose for VNS Therapy in Epilepsy. Read More

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A Computational Biomarker of Photosensitive Epilepsy from Interictal EEG.

eNeuro 2022 May-Jun;9(3). Epub 2022 Jun 21.

Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF24 4HQ, United Kingdom.

People with photosensitive epilepsy (PSE) are prone to seizures elicited by visual stimuli. The possibility of inducing epileptiform activity in a reliable way makes PSE a useful model to understand epilepsy, with potential applications for the development of new diagnostic methods and new treatments for epilepsy. A relationship has been demonstrated between PSE and both occipital and more widespread cortical hyperexcitability using various types of stimulation. Read More

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Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology.

Epilepsy Behav 2022 Jul 25;132:108739. Epub 2022 May 25.

Regional Health Agency of Tuscany, Firenze, Italy.

The incidence of epilepsy is highest at the extreme age ranges: childhood and elderly age. The most common syndromes in these demographics - self-limited epilepsies of childhood and idiopathic generalized epilepsies in pediatric age, focal epilepsy with structural etiology in older people - are expected to be drug responsive. In this work, we focus on such epilepsy types, overviewing the complex clinical background of unexpected drug-resistance. Read More

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Deep Convolutional Gated Recurrent Unit Combined with Attention Mechanism to Classify Pre-Ictal from Interictal EEG with Minimized Number of Channels.

J Pers Med 2022 May 9;12(5). Epub 2022 May 9.

Department of Artificial Intelligence, The Catholic University of Korea, Seoul 14662, Korea.

The early prediction of epileptic seizures is important to provide appropriate treatment because it can notify clinicians in advance. Various EEG-based machine learning techniques have been used for automatic seizure classification based on subject-specific paradigms. However, because subject-specific models tend to perform poorly on new patient data, a generalized model with a cross-patient paradigm is necessary for building a robust seizure diagnosis system. Read More

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FDG-PET findings and alcohol-responsive myoclonus in a patient with Unverricht-Lundborg disease.

Epilepsy Behav Rep 2022 13;19:100551. Epub 2022 May 13.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

The aim of this report is to describe clinical, EEG, and neuroimaging findings in a patient with Unverricht-Lundborg disease (ULD), the most common form of progressive myoclonus epilepsy (PME). A 23-year-old male with genetically confirmed ULD had a phenotype consisting of myoclonus, generalized seizures, intellectual disability, ataxia, and dysarthria. Myoclonus and gait disturbance were strongly ameliorated by alcohol consumption. Read More

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Focal seizures during adrenocorticotropic hormone therapy in a school-aged boy: a case report.

J Med Case Rep 2022 May 24;16(1):200. Epub 2022 May 24.

Department of Pediatrics, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Background: Adrenocorticotropic hormone therapy for infantile spasms, including West syndrome, has been previously reported to induce seizures. We present the findings for a school-aged child with epilepsy who developed new focal seizures during adrenocorticotropic hormone therapy.

Case Presentation: The Japanese patient had posttraumatic epilepsy and developed intractable focal seizures at the age of 13 years. Read More

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Epilepsy in neurodegenerative diseases.

Epileptic Disord 2022 Apr;24(2):249-273

Danish Epilepsy Centre, Dianalund, Denmark.

Although epilepsy as a comorbidity in neurodegenerative disorders is increasingly recognized, its incidence is still underestimated and the features of epilepsy in the different neurodegenerative conditions are still poorly defined. Improved health care, resulting in increased longevity, will unavoidably lead to an increment of epilepsy cases in the elderly. Thus, it is conceivable to expect that neurologists will have to deal with these comorbid conditions to a growing extent in the future. Read More

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Testicular androgens determining the incidence of spike-wave discharges in taiep rats: A model of H-ABC leukodystrophy.

Neurosci Lett 2022 06 17;782:136684. Epub 2022 May 17.

Institute of Physiology, Av. 14 Sur # 6301. Col. Jardínes de San Manuel, Puebla, Pue. C.P. 72570, Mexico; International Office, Benemérita Universidad Autónoma de Puebla. Torre de Gestión Académica y Servicios Administrativos, 3(er) piso. Col. Jardínes de San Manuel, Puebla, Pue. C.P. 72570, Mexico. Electronic address:

Absence seizures are characterized as a generalized type of epilepsy that occurs during childhood. Importantly, absence seizures in children often discontinue after puberty. There is limited availability of animal models in which electroencephalography (EEG) can be performed in the long term; however, two absence seizure models, GAERS and WAG/Rij albino rats, are available. Read More

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Seizures and COVID-19: Results from the Spanish Society of Neurology's COVID-19 registry.

J Clin Neurosci 2022 Jul 16;101:112-117. Epub 2022 May 16.

Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, c/ Diego de Velázquez, 1, 28223 Pozuelo de Alarcón, Madrid, Spain.

We describea series of patients with COVID-19 who presented with seizures, reported in the Spanish Society of Neurology's COVID-19 Registry. This observational, descriptive,multicentre, registry-based study includes patients with confirmed COVID-19 who experienced seizures during active infection.Wedescribe theclinicalpresentation of COVID-19,seizures,and resultsof complementary tests. Read More

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Long-term changes in electroencephalogram findings in a girl with a nonsense SMC1A variant: A case report.

Brain Dev 2022 May 16. Epub 2022 May 16.

Department of Mental Retardation and Birth Defect Research, NCNP, Kodaira, Tokyo, Japan; Medical Genome Center, NCNP, Kodaira, Tokyo, Japan.

Introduction: Pathogenic truncating variants in SMC1A, which is located on chromosome Xp11.2, are known to cause infantile-onset epilepsy and severe intellectual disability in girls. Several studies have reported a correlation between SMC1A truncations and seizure clustering; however, the associated electroencephalogram (EEG) patterns remain largely unknown. Read More

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Neuropathology findings in KCNQ2 neonatal epileptic encephalopathy.

Seizure 2022 Jul 10;99:36-39. Epub 2022 May 10.

Université de Paris, AP-HP, Hôpital Robert-Debré, INSERM NeuroDiderot, DMU Innov-RDB, Neurologie Pédiatrique, Paris, France.

Purpose: KCNQ2-epileptic encephalopathy (EE) is a neonatal epilepsy syndrome characterized by a typical clinical presentation and EEG recording, but without any brain or cortical abnormal development on MRI. Most of the patients have a severe developmental impairment. The epileptogenic mechanisms are thought to be the result of the changes of the M-current density causing a change of brain excitability. Read More

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mGlu3 metabotropic glutamate receptors as a target for the treatment of absence epilepsy: preclinical and human genetics data.

Curr Neuropharmacol 2022 May 9. Epub 2022 May 9.

University of Catanzaro, School of Medicine, Science of Health Department, [email protected] Research Center, Catanzaro, Italy.

Background: Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for the treatment of absence epilepsy. However, no information is available on mGlu3 receptors. Objective To examine whether (i) abnormalities changes of mGlu3 receptor expression/signaling are found in the somatosensory cortex and thalamus of WAG/Rij rats developing spontaneous absence seizures; (ii) selective activation of mGlu3 receptors with LY2794193 affects the number and duration of spike-wave discharges (SWDs) in WAG/Rij rats; and (iii) a genetic variant of GRM3 (encoding the mGlu3 receptor) is associated with absence epilepsy. Read More

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Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies?

Front Neurol 2022 27;13:831546. Epub 2022 Apr 27.

Department of Neurology, University of Pittsburgh Comprehensive Epilepsy Center (UPCEC), University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.

According to the latest operational 2017 ILAE classification of epileptic seizures, the generalized epileptic seizure is still conceptualized as "originating at some point within and rapidly engaging, bilaterally distributed networks." In contrast, the focal epileptic seizure is defined as "." Hence, one of the main concepts of "generalized" and "focal" epilepsy comes from EEG descriptions before the era of source localization, and a presumed simultaneous bilateral onset and bi-synchrony of epileptiform discharges remains a hallmark for generalized seizures. Read More

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Clinical Characteristics and Etiology of Epilepsy in Children Aged Below Two Years: Perspective From a Tertiary Childcare Hospital in South Punjab, Pakistan.

Zia Ur Rehman

Cureus 2022 Apr 5;14(4):e23854. Epub 2022 Apr 5.

Pediatric Neurology, The Children's Hospital and Institute of Child Health, Multan, PAK.

Background Epilepsy is described as an enduring disposition toward recurrent unprovoked seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition. This study aimed to find the clinical characteristics and etiology of epilepsy in children aged below two years. Methodology This cross-sectional study was conducted at the department of pediatric neurology, the Children's Hospital and Institute of Child Health, Multan, Pakistan, from February 2021 to July 2021. Read More

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