9,988 results match your criteria Generalized Epilepsies on EEG


Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy. Reply.

N Engl J Med 2019 04;380(16)

University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1056/NEJMc1805100DOI Listing

Intestinal-Cell Kinase and Juvenile Myoclonic Epilepsy.

N Engl J Med 2019 04;380(16)

University of Tübingen, Tübingen, Germany

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http://dx.doi.org/10.1056/NEJMc1805100DOI Listing

Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy: A case report and review of the literature.

Epilepsy Behav Case Rep 2019 7;11:107-114. Epub 2019 Mar 7.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka City, Osaka, Japan.

Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare pathological lesions that can present anywhere in the central nervous system. Symptoms vary depending on the location, though they often include seizures, especially in intracranial and supratentorial lesions. A case of intracranial supratentorial CAPNON presenting with drug-resistant left temporal lobe epilepsy is reported. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434061PMC
March 2019
1 Read

The yield of electroencephalography in syncope.

Ideggyogy Sz 2019 Mar;72(3-4):111-114

Ankara Numune Training and Research Hospital, Neurology Department, Ankara, Turkey.

Background And Purpose: Syncope is defined as a brief transient loss of consciousness due to cerebral hypoperfusion. Although the diagnosis of syncope is based on a thorough history and examination, electroencaphalography (EEG) is also an important investigational tool in the differential diagnosis in this group of patients. In this study we aimed to identify the diagnostic value of EEG in patients with syncope. Read More

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http://dx.doi.org/10.18071/isz.72.0111DOI Listing

EEG-based connectivity in patients with partial seizures with and without generalization.

Ideggyogy Sz 2019 Mar;72(3-4):99-109

University of Debrecen, Medical Center, Department of Neurology, Debrecen.

Background And Purpose: To investigate the neurophysiological basis of secondary generalization of partial epileptic seizures.

Methods: Inter-ictal, resting-state EEG functional connectivity (EEGfC) was evaluated and compared: patients with exclusively simple partial seizures (sp group) were compared to patients with simple partial and secondary generalized seizures (spsg group); patients with exclusively complex partial seizures (cp group) were compared to patients with cp and secondary generalized seizures (cpsg group); the collapsed sp+cp group (spcp) was compared to those who had exclusively secondary generalized seizures (sg group). EEGfC was computed from 21-channel waking EEG. Read More

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http://www.elitmed.hu/kiadvanyaink/ideggyogyaszati-szemle/ke
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http://dx.doi.org/10.18071/isz.72.0099DOI Listing
March 2019
2 Reads

Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.

Brain Dev 2019 Apr 2. Epub 2019 Apr 2.

Genetic and Metabolic Department, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objective: EAST syndrome comprises of epilepsy, ataxia, sensorineural deafness, and tubulopathy. It is caused by a mutation in KCNJ10 gene. Less than thirty cases have been reported in the literature with emphasis on genetic mutation and renal tubulopathy. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.009DOI Listing
April 2019
2 Reads

Childhood-only epilepsy with generalized tonic-clonic seizures: A well-defined epileptic syndrome.

Epilepsy Res 2019 Mar 27;153:28-33. Epub 2019 Mar 27.

Department of Neurology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Purpose: The aim of this study was to analyze patients whose only manifestation of epilepsy were generalized tonic-clonic seizures (GTCS) during childhood and discuss its validity as separate syndrome of childhood.

Methods: We included children with at least two unprovoked GTCS between 3 and 11 years of age, no other seizure types at diagnosis, normal psychomotor development and neurological examination, an EEG with normal background and paroxysms of generalized spikes and waves with a frequency 2.5 Hz or above, and an unknown cause for epilepsy. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.017DOI Listing
March 2019
1 Read

Rasmussen's Epileptogenic Encephalitis in a Tropical Country.

J Pediatr Neurosci 2018 Oct-Dec;13(4):490-495

Department of Neurology, Campus University Teaching Hospital, University of Lomé, Lomé, Togo.

Background: Encephalitis of Rasmussen is an inflammatory hemiencephalopathy of unknown etiology. It is a cause of drug-resistant epilepsy.

Aim: To report two cases of Rasmussen's encephalitis (RE) in a low-income setting. Read More

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http://dx.doi.org/10.4103/JPN.JPN_51_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413596PMC
April 2019
3 Reads

MEF2C-related epilepsy: Delineating the phenotypic spectrum from a novel mutation and literature review.

Seizure 2019 Mar 22. Epub 2019 Mar 22.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: MEF2C-related epilepsy has been poorly described in the literature, despite a consistent MEF2C haploinsufficiency phenotype characterized by severe language impairment and motor delay (MIM# 613443). We aimed to delineate the spectrum of electroclinical manifestations of MEF2C-related epilepsy from an illustrative case and literature review.

Methods: A retrospective chart review of our case was performed followed by a literature review on PubMed and OMIM. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.015DOI Listing
March 2019
2 Reads

Epilepsy Overview and Revised Classification of Seizures and Epilepsies.

Authors:
Alison M Pack

Continuum (Minneap Minn) 2019 04;25(2):306-321

Purpose Of Review: The classification of seizures, epilepsies, and epilepsy syndromes creates a framework for clinicians, researchers, and patients and their families. This classification has evolved over the years, and in 2017 the International League Against Epilepsy (ILAE) published an operational classification of seizures and epilepsies. Understanding this classification is important in the diagnosis, treatment, and understanding of seizures and epilepsies, including epilepsy incidence. Read More

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http://dx.doi.org/10.1212/CON.0000000000000707DOI Listing
April 2019
2 Reads

Non convulsive status epilepticus in the elderly.

Authors:
Sophie Dupont

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(S1):25-30

Epilepsy Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Rehabilitation Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Centre de recherche de l'Institut du cerveau et de la moelle épinière (ICM), UMPC-UMR 7225 CNRS-UMRS 975 Inserm, Paris, France, Université Paris Sorbonne, France.

Non-convulsive status epilepticus (NCSE) is common in the elderly. It most often corresponds to prolonged focal seizures with impaired contact ("complex partial status epilepticus"). A form of de novo absence status epilepticus, much rarer, can also meet. Read More

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http://dx.doi.org/10.1684/pnv.2019.0782DOI Listing
March 2019
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Reusable Electroencephalography Electrodes: Variability in Cleaning and Reprocessing Practices.

Neurodiagn J 2019 ;59(1):45-57

a Office of Nursing Research and Innovation Cleveland Clinic , Cleveland , Ohio.

Of 124 reusable electroencephalography cup electrodes/lead wires from four epilepsy monitoring units, 25% had bacterial growth. Institutional cleaning practices of electroencephalography cup electrode lead wires may contribute to positive culture prevalence. In this study, personnel who supervised cleaning of electroencephalography cup electrodes/lead wires completed an investigator-developed survey. Read More

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http://dx.doi.org/10.1080/21646821.2019.1571357DOI Listing
January 2019

[Features of ictal and interictal electrical activity in assessment of the epileptogenic zone in children with focal cortical dysplasias].

Zh Vopr Neirokhir Im N N Burdenko 2019;83(1):90-97

Burdenko Neurosurgical Institute, Moscow, Russia.

Currently, there is no single standard defining what rhythmic activity should be considered as the area of ictal pattern onset. Differences in electroencephalographic patterns associated with different types of focal cortical dysplasias (FCDs) have not been defined. Aim - we aimed to identify features of the ictal onset pattern on a scalp EEG, depending on the histology, location, and extension of epileptogenic zone, as well as to elucidate the relationship between concordance of the interictal and ictal activity localization and ictal onset pattern types. Read More

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http://dx.doi.org/10.17116/neiro20198301190DOI Listing
January 2019

Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES).

Epilepsy Behav 2019 Mar 18;94:93-99. Epub 2019 Mar 18.

Minnesota Epilepsy Group, P.A., St. Paul, Minnesota, USA; Children's Hospitals and Clinics of Minnesota, St. Paul, Minnesota, USA.

Few studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.016DOI Listing
March 2019
1 Read

Non-convulsive status epilepticus associated with neuronal intranuclear inclusion disease: A case report and literature review.

Epilepsy Behav Case Rep 2019 26;11:103-106. Epub 2019 Jan 26.

Department of Neurology, University of Yamanashi, Yamanashi, Japan.

We report a case of neuronal intranuclear inclusion disease (NIID) confirmed by detection of intranuclear inclusions in a skin biopsy specimen. Brain magnetic resonance imaging showed mild cerebral atrophy and linear hyperintensities at the corticomedullary junction on diffusion-weighted images. This patient developed nonconvulsive status epilepticus with generalized periodic discharges on electroencephalography after recurrent symptoms of paroxysmal nausea and slowly progressive cognitive decline. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403408PMC
January 2019

Incidence, Recurrence, and Risk Factors for Peri-ictal Central Apnea and Sudden Unexpected Death in Epilepsy.

Front Neurol 2019 1;10:166. Epub 2019 Mar 1.

Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States.

Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e. Read More

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http://dx.doi.org/10.3389/fneur.2019.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413671PMC
March 2019
1 Read

Epileptological aspects of juvenile neuronal ceroid lipofuscinosis (CLN3 disease) through the lifespan.

Epilepsy Behav 2019 Mar 15;94:59-64. Epub 2019 Mar 15.

Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Purpose: Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is the most common neurodegenerative disorder in childhood with survival until young adult age. Visual loss is followed by epilepsy, cognitive, neuropsychiatric, and motor symptoms. We have studied the evolution of electroencephalographic (EEG) and seizure characteristics. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.020DOI Listing
March 2019
1 Read

Videogame-Induced Theta Rhythm.

J Clin Neurophysiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Neurology, Mayo Clinic, Jacksonville, Florida, U.S.A.

Smartphones and other personal electronic devices present novel cortical processing tasks with potential for identification of novel EEG waveforms. A 17-year-old patient with epilepsy manifested as recurrent myoclonic seizures, absence seizures, and a single generalized tonic-clonic seizure was hospitalized to undergo video-EEG monitoring for seizure quantification and classification of the epilepsy syndrome. During the monitoring session, a frontocentral predominant 5 to 6 Hz theta rhythm was identified only when the patient was actively texting or playing a videogame on his smartphone. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000575DOI Listing
March 2019
1 Read

A case of childhood absence epilepsy with focal spikes.

World Neurosurg 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

Childhood absence epilepsy (CAE) is a common generalized epilepsy syndrome characterized by childhood onset of frequent sporadic absence seizures. During onset, the electroencephalogram (EEG) exhibits bilateral, symmetrical and synchronous discharges of approximately 3 Hz of generalized spike-and-wave complexes. Focal spikes are often found in children with focal epilepsy, but are not common in absence epilepsy. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.225DOI Listing
March 2019
2 Reads

Impact of withdrawal of antiepileptic medication on the duration of focal onset seizures.

Seizure 2019 Mar 8;67:40-44. Epub 2019 Mar 8.

Epilepsy Center, Department of Neurology, University Hospital, LMU Munich, Munich, Germany.

Purpose: To systematically evaluate the duration of focal onset seizures under medication withdrawal as a function of drug half-life.

Methods: Adults with drug resistant focal epilepsy and invasive electroencephalographic (iEEG) recording between 01/2006 and 06/2016 (n = 128) were identified. Patients with multifocal or unknown epileptic foci were excluded, as well as subclinical seizures, isolated auras, or status epileptic. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.005DOI Listing
March 2019
2 Reads

Phase clustering in transcranial magnetic stimulation-evoked EEG responses in genetic generalized epilepsy and migraine.

Epilepsy Behav 2019 Mar 12;93:102-112. Epub 2019 Mar 12.

Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103 SW Heemstede, the Netherlands; Image Sciences Institute, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, the Netherlands.

Background: Epilepsy and migraine are paroxysmal neurological conditions associated with disturbances of cortical excitability. No useful biomarkers to monitor disease activity in these conditions are available. Phase clustering was previously described in electroencephalographic (EEG) responses to photic stimulation and may be a potential epilepsy biomarker. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.029DOI Listing
March 2019
4 Reads
2.257 Impact Factor

Recognition of Multiclass Epileptic EEG Signals Based on Knowledge and Label Space Inductive Transfer.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 13;27(4):630-642. Epub 2019 Mar 13.

Electroencephalogram (EEG) signal recognition based on machine learning models is becoming more and more attractive in epilepsy detection. For multiclass epileptic EEG signal recognition tasks including the detection of epileptic EEG signals from different blends of different background data and epilepsy EEG data and the classification of different types of seizures, we may perhaps encounter two serious challenges: (1) a large amount of EEG signal data for training are not available and (2) the models for epileptic EEG signal recognition are often so complicated that they are not as easy to explain as a linear model. In this paper, we utilize the proposed transfer learning technique to circumvent the first challenge and then design a novel linear model to circumvent the second challenge. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2904708DOI Listing

Slower alpha rhythm associates with poorer seizure control in epilepsy.

Ann Clin Transl Neurol 2019 Feb 18;6(2):333-343. Epub 2018 Dec 18.

Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience King's College London London United Kingdom.

Objective: Slowing and frontal spread of the alpha rhythm have been reported in multiple epilepsy syndromes. We investigated whether these phenomena are associated with seizure control.

Methods: We prospectively acquired resting-state electroencephalogram (EEG) in 63 patients with focal and idiopathic generalized epilepsy (FE and IGE) and 39 age- and gender-matched healthy subjects (HS). Read More

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http://dx.doi.org/10.1002/acn3.710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389754PMC
February 2019

Multimodal wrist-worn devices for seizure detection and advancing research: Focus on the Empatica wristbands.

Epilepsy Res 2019 Feb 27. Epub 2019 Feb 27.

Empatica, Milan, Italy; Empatica, Cambridge, MA, USA; MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.

Wearable automated seizure detection devices offer a high potential to improve seizure management, through continuous ambulatory monitoring, accurate seizure counts, and real-time alerts for prompt intervention. More importantly, these devices can be a life-saving help for people with a higher risk of sudden unexpected death in epilepsy (SUDEP), especially in case of generalized tonic-clonic seizures (GTCS). The Embrace and E4 wristbands (Empatica) are the first commercially available multimodal wristbands that were designed to sense the physiological hallmarks of ongoing GTCS: while Embrace only embeds a machine learning-based detection algorithm, both E4 and Embrace devices are equipped with motion (accelerometers, ACC) and electrodermal activity (EDA) sensors and both the devices received medical clearance (E4 from EU CE, Embrace from EU CE and US FDA). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.007DOI Listing
February 2019
6 Reads

Doxycycline for the treatment of nodding syndrome (DONS); the study protocol of a phase II randomised controlled trial.

BMC Neurol 2019 Mar 6;19(1):35. Epub 2019 Mar 6.

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, OX3 7FZ, UK.

Background: Nodding syndrome is a poorly understood neurological disorder of unknown aetiology, affecting several thousand children in Africa. There has been a consistent epidemiological association with infection by the filarial parasite, Onchocerca volvulus and antibodies to leiomodin and DJ-1, cross-reacting with O.volvulus proteins, have been reported. Read More

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http://dx.doi.org/10.1186/s12883-019-1256-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402111PMC
March 2019
3 Reads

Tonic status epilepticus in a centenarian woman.

Epileptic Disord 2019 Feb;21(1):92-96

Department of Neurology, Marqués de Valdecilla University Hospital, Santander, Spain.

Generalized tonic status epilepticus (TSE) is a rare epileptic condition. It occurs usually in the context of symptomatic generalized epilepsy, in particular, in subjects with a diagnosis of Lennox-Gastaut syndrome, atypical forms of idiopathic (genetic) generalized epilepsy, or as a paradoxical effect during treatment with diverse antiepileptic drugs. Herein, we describe the case of an elderly woman on chronic treatment with psychotropic drugs who developed an episode of generalized TSE. Read More

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http://dx.doi.org/10.1684/epd.2019.1031DOI Listing
February 2019
6 Reads

Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report.

Medicine (Baltimore) 2019 Feb;98(8):e14698

Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Rationale: The phenotypic spectrum caused by SCN2A mutations includes benign neonatal/infantile seizures, Ohtahara syndrome, infantile spasms, West syndrome, and other unclassified epileptic phenotypes. Mutations in SCN2A have been implicated in neonatal seizure cases. Here, we described a Chinese family with 2 members having juvenile-onset myoclonus and identified a novel SCN2A point mutation within this family. Read More

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http://dx.doi.org/10.1097/MD.0000000000014698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408085PMC
February 2019
5 Reads

Endosulfan-Induced Prolonged Super-Refractory Status Epilepticus.

J Epilepsy Res 2018 Dec 31;8(2):93-96. Epub 2018 Dec 31.

Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Endosulfan is a highly toxic pesticide that causes hyperstimulation of the central nervous system by antagonizing gamma aminobutyric acid-mediated inhibition. Seizure is the most important manifestation of endosulfan poisoning, frequently progressing to status epilepticus and refractory status epilepticus. Here, we report a recent case of a 64-year-old man with endosulfan-induced super-refractory status epilepticus, which persisted for a remarkably longer period than has been described in previous reports. Read More

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http://j-epilepsy.org/journal/view.php?doi=10.14581/jer.1801
Publisher Site
http://dx.doi.org/10.14581/jer.18016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374535PMC
December 2018
5 Reads

Vagus Nerve Stimulation (VNS) in Super Refractory New Onset Refractory Status Epilepticus (NORSE).

Case Rep Neurol Med 2019 21;2019:7852017. Epub 2019 Jan 21.

Department of Neurocritical Care, Inova Fairfax Hospital, Falls Church, VA, USA.

The treatment protocol of status epilepticus has many associated toxicities so there is interest in alternate nonmedicinal therapies for managing New Onset Refractory Status Epilepticus (NORSE) patients. Vagus nerve stimulation (VNS) is an FDA-approved therapy for refractory epilepsy that has been shown to decrease the frequency and severity of seizures. We present the case of a patient with new-onset refractory status epilepticus (NORSE) whose seizures were successfully treated with vagus nerve stimulation. Read More

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http://dx.doi.org/10.1155/2019/7852017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360559PMC
January 2019
3 Reads

Seizure detection devices for use in antiseizure medication clinical trials: A systematic review.

Seizure 2019 Mar 13;66:61-69. Epub 2019 Feb 13.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; School of Interactive Computing, Georgia Institute of Technology, 85 Fifth Street NW, Atlanta, GA, USA.

Objective: This study characterizes the current capabilities of seizure detection device (SDD) technology and evaluates the fitness of these devices for use in anti-seizure medication (ASM) clinical trials.

Methods: Through a systematic literature review, 36 wireless SDDs featured in published device validation studies were identified. Each device's seizure detection capabilities that addressed ASM clinical trial primary endpoint measurement needs were cataloged. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.007DOI Listing
March 2019
3 Reads

Ictal biting injuries in the epilepsy monitoring unit, a cohort study of incidence and semiological significance.

Seizure 2019 Mar 14;66:39-41. Epub 2019 Feb 14.

Epilepsy Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44106, United States of America.

Purpose: Oral biting injuries are widely recognized complications of seizures. Value in differentiating epileptic vs paroxysmal non-epileptic seizures is well demonstrated, but frequency and semiological value are poorly described. We aimed to evaluate frequency in an epilepsy monitoring unit setting as well as semiological value. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183081
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http://dx.doi.org/10.1016/j.seizure.2019.02.005DOI Listing
March 2019
4 Reads

A novel mutation in KCNQ3-related benign familial neonatal epilepsy: electroclinical features and neurodevelopmental outcome.

Epileptic Disord 2019 Feb;21(1):87-91

Department of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro," University of Palermo, Palermo.

Benign familial neonatal epilepsy (BFNE) is caused, in about 5% of families, by mutations in the KCNQ3 gene encoding voltage-gated potassium channel subunits. Usually, newborns with BFNE show a normal neurological outcome, but recently, refractory seizures and/or developmental disability have been reported suggesting phenotype variability associated with KCNQ3-related BFNE. Here, we describe a proband from a BFNE family carrying a novel variant in the KCNQ3 gene. Read More

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http://dx.doi.org/10.1684/epd.2019.1030DOI Listing
February 2019

Berardinelli-Seip syndrome and progressive myoclonus epilepsy.

Epileptic Disord 2019 Feb;21(1):117-121

Child Neurology and Psychiatry Unit, "Regina Montis Regalis" Hospital, Mondovì.

Berardinelli-Seip syndrome, or congenital generalized lipodystrophy type 2 (CGL2), is characterized by a lack of subcutaneous adipose tissue and precocious metabolic syndrome with insulin resistance, resulting in diabetes, dyslipidaemia, hepatic steatosis, cardiomyopathy, and acanthosis nigricans. Most reported mutations are associated with mild, non-progressive neurological impairment. We describe the clinical and EEG data of a patient with progressive myoclonus epilepsy (PME), CGL2, and progressive neurological impairment, carrying a homozygous BSCL2 nonsense mutation. Read More

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http://dx.doi.org/10.1684/epd.2019.1038DOI Listing
February 2019
4 Reads

Regional specificity of cortico-thalamic coupling strength and directionality during waxing and waning of spike and wave discharges.

Sci Rep 2019 Feb 14;9(1):2100. Epub 2019 Feb 14.

Institute of Physiology I, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Spike-wave discharges (SWDs) on the EEG during absence epilepsy are waxing and waning stages of corticothalamic hypersynchrony. While the somatosensory cortex contains an epileptic focus, the role of thalamic nuclei in SWD generation is debated. Here we assess the contribution of distinct thalamic nuclei through multiple-site unit recordings in a genetic rat model of absence epilepsy and cross-correlation analysis, revealing coupling strength and directionality of neuronal activity at high temporal resolution. Read More

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http://dx.doi.org/10.1038/s41598-018-37985-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375974PMC
February 2019

Ventilatory response to CO in patients with epilepsy.

Epilepsia 2019 Mar 12;60(3):508-517. Epub 2019 Feb 12.

Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Objective: Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO (hypercapnic ventilatory response [HCVR] or central respiratory CO chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs). Read More

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http://dx.doi.org/10.1111/epi.14660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401234PMC
March 2019
3 Reads

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019
1 Read
2.440 Impact Factor

Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
February 2019
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Tonic Seizure as a Different Seizure Type Presented in Autoimmune Epilepsy Caused by Systemic Lupus Erythematosus.

J Nerv Ment Dis 2019 Mar;207(3):188-191

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of JiLin University, Changchun, People's Republic of China.

The diagnosis of autoimmune epilepsy is often challenging, and may be misdiagnosed as epileptic disorders or viral encephalitis. Autoimmune epilepsy has a strong association with other autoimmune diseases, especially systemic lupus erythematosus (SLE). In addition, autoimmune epilepsy was reported to present with complex partial seizure (CPS), simple partial seizure (SPS), and secondarily generalized tonic-clonic seizure (sGTCS). Read More

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http://dx.doi.org/10.1097/NMD.0000000000000946DOI Listing
March 2019
4 Reads

Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Cochrane Database Syst Rev 2019 02 8;2:CD003032. Epub 2019 Feb 8.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro, 10, Verona, Verona, Italy, 37134.

Background: This is an updated version of the Cochrane Review previously published in 2017.Absence seizures (AS) are brief epileptic seizures which present in childhood and adolescence. Depending on clinical features and electroencephalogram (EEG) findings they are divided into typical, atypical absences, and absences with special features. Read More

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http://dx.doi.org/10.1002/14651858.CD003032.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367681PMC
February 2019
1 Read

A Practical Guide to Treatment of Childhood Absence Epilepsy.

Paediatr Drugs 2019 Feb;21(1):15-24

Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.

Childhood absence epilepsy (CAE) is a common pediatric epilepsy syndrome with distinct seizure semiology, electroencephalography (EEG) features, and treatment. A diagnosis of CAE can be obtained during an office visit with a careful history, physical exam including prolonged hyperventilation, and a routine EEG. The treatment of choice for CAE with absence seizures only is ethosuximide. Read More

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http://dx.doi.org/10.1007/s40272-019-00325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394437PMC
February 2019
2 Reads

Cerebrospinal fluid changes following epileptic seizures unrelated to inflammation.

Eur J Neurol 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurology, University Medicine Greifswald, Greifswald.

Background And Purpose: Analyzing cerebrospinal fluid (CSF) is crucial in the diagnostic workup of epileptic seizures to rule out autoimmunity or infections as the underlying cause. Therefore, the description of post-ictal changes in CSF is essential to differentiate between negligible and etiopathologically relevant changes in the CSF profile.

Methods: A retrospective analysis of 247 patients newly diagnosed with epileptic seizures and CSF analysis during diagnostic workup was conducted. Read More

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http://dx.doi.org/10.1111/ene.13924DOI Listing
February 2019
7 Reads

Diagnostic usefulness of arterial spin labeling in MR negative children with new onset seizures.

Seizure 2019 Feb 27;65:151-158. Epub 2019 Jan 27.

Department of Pediatric, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. Electronic address:

Purpose: Arterial spine labeling (ASL) magnetic resonance imaging (MRI) is the non-invasive measurement of cerebral blood flow that can localize the seizure focus in patients with epilepsy. The aim of this study was to identify its utility for localizing the seizure focus in children with no structural lesion on MRI.

Methods: Forty-three consecutive children who underwent electroencephalography (EEG) and structural MRI, along with ASL for evaluation of newly developed seizures, were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183070
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http://dx.doi.org/10.1016/j.seizure.2019.01.024DOI Listing
February 2019
8 Reads

Concordance between the interictal focal EEG pattern and MRI lesions as a predictor of a favorable surgical outcome in patients with epileptic spasms: a Chinese study.

J Neurosurg Pediatr 2019 02 1:1-10. Epub 2019 Feb 1.

Departments of1Functional Neurosurgery and.

OBJECTIVE The aim of this study was to evaluate the electro-clinical features, etiology, treatment, and postsurgical seizure outcomes in patients with intractable epileptic spasms (ESs). METHODS The authors retrospectively studied the medical records of all patients who had presented with medically intractable ESs and had undergone surgery in the period between October 2009 and August 2015. The interictal electroencephalography (EEG) pattern, MRI studies, magnetoencephalography findings, and postsurgical seizure outcomes were compared. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18380DOI Listing
February 2019
3 Reads

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient.

Curr Opin Neurol 2019 Apr;32(2):205-212

NINDS Center for SUDEP Research and Texas Comprehensive Epilepsy Center, University of Texas Houston Health Sciences Center, Houston, Texas, USA.

Purpose Of Review: The current review updates our knowledge regarding sudden unexpected death in epilepsy patient (SUDEP) risks, risk factors, and investigations of putative biomarkers based on suspected mechanisms of SUDEP.

Recent Findings: The overall incidence of SUDEP in adults with epilepsy is 1.2/1000 patient-years, with surprisingly comparable figures in children in recently published population-based studies. Read More

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http://Insights.ovid.com/crossref?an=00019052-201904000-0000
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http://dx.doi.org/10.1097/WCO.0000000000000668DOI Listing
April 2019
3 Reads

Magnetic resonance imaging and electroencephalography findings in a sample of Iranian patients with epilepsy.

J Res Med Sci 2018 28;23:106. Epub 2018 Dec 28.

Isfahan Neurosciences Research Centre, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The present study is aimed to evaluate the magnetic resonance imaging (MRI) and electroencephalography (EEG) findings based on characteristics variables in patients with epilepsy.

Materials And Methods: In this cross-sectional study, all patients with epilepsy who referred between March 2016 and March 2017 to Al-Zahra and Kashani Hospitals in Isfahan, Iran, were enrolled. The completed files of 199 patients were assessed to collect information about characteristic data and MRI and EEG findings. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327682PMC
December 2018
1 Read
0.608 Impact Factor

Baclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Royal Perth Hospital, Perth, Australia.

Purpose: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal and opiate dependency. Given the increasing use of baclofen we describe the clinical and electrographical features of baclofen neurotoxicity seen at our institution. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000565DOI Listing
January 2019
3 Reads

Expanding the Phenotypic Spectrum of CACNA1H Mutations.

Pediatr Neurol 2019 Apr 19;93:50-55. Epub 2018 Dec 19.

McGovern Medical School, UTHealth, Mitochondrial Center of Excellence, Houston, Texas.

Background: The CACNA1H gene mutations encoding the α subunit of Cav3.2 T-type calcium channels have been associated with generalized epilepsy. Focal or multifocal epilepsy and systemic (immunologic and gastrointestinal) involvement associated with these mutations have not been described previously. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.017DOI Listing
April 2019
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Chewing induced reflex seizures ("eating epilepsy") and eye closure sensitivity as a common feature in pediatric patients with SYNGAP1 mutations: Review of literature and report of 8 cases.

Seizure 2019 Feb 22;65:131-137. Epub 2018 Dec 22.

Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria; Hospital for Neuropediatrics and Neurological Rehabilitation, Epilepsy Center for Children and Adolescents, Krankenhausstr. 20, 83569 Vogtareuth, Germany.

Purpose: Heterozygous SYNGAP1 gene mutations have been associated with several forms of idiopathic generalized epilepsy, autism spectrum disorders and delay of psychomotor development. We report eight patients with a SYNGAP1 mutation and chewing/eating induced reflex seizures as new phenotype and compare them to other patients with eating epilepsy and genetic mutations.

Methods: Presentation of clinical and anamnestic features and retrospective analysis of Video-EEG data of a 4 year old index patient with SYNGAP1 mutation and chewing /eating induced seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183046
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http://dx.doi.org/10.1016/j.seizure.2018.12.020DOI Listing
February 2019
11 Reads

Cannabidiol (Epidiolex) for epilepsy.

Authors:

Med Lett Drugs Ther 2018 Nov;60(1559):182-184

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November 2018
1 Read

Non-electroencephalography-based seizure detection.

Curr Opin Neurol 2019 Apr;32(2):198-204

Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus.

Purpose Of Review: There is need for automated seizure detection using mobile or wearable devices, for objective seizure documentation and decreasing morbidity and mortality associated with seizures. Due to technological development, a high number of articles have addressed non-electroencephalography (EEG)-based seizure detection. However, the quality of study-design and reporting is extremely heterogeneous. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000658DOI Listing
April 2019
2 Reads