8,697 results match your criteria Generalized Anxiety Disorder


Blended Care-Cognitive Behavioral Therapy for Depression and Anxiety in Real-World Settings: Pragmatic Retrospective Study.

J Med Internet Res 2020 Jul 6;22(7):e18723. Epub 2020 Jul 6.

Lyra Health, Burlingame, CA, United States.

Background: The past few decades saw considerable advances in research and dissemination of evidence-based psychotherapies, yet available treatment resources are not able to meet the high need for care for individuals suffering from depression or anxiety. Blended care psychotherapy, which combines the strengths of therapist-led and internet interventions, can narrow this gap and be clinically effective and efficient, but has rarely been evaluated outside of controlled research settings.

Objective: This study evaluated the effectiveness of a blended care intervention (video-based cognitive behavior therapy and internet intervention) under real-world conditions. Read More

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http://dx.doi.org/10.2196/18723DOI Listing

The Acceptability and Usability of Digital Health Interventions for Adults With Depression, Anxiety, and Somatoform Disorders: Qualitative Systematic Review and Meta-Synthesis.

J Med Internet Res 2020 Jul 6;22(7):e16228. Epub 2020 Jul 6.

Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Background: The prevalence of mental health disorders continues to rise, with almost 4% of the world population having an anxiety disorder and almost 3.5% having depression in 2017. Despite the high prevalence, only one-third of people with depression or anxiety receive treatment. Read More

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http://dx.doi.org/10.2196/16228DOI Listing

Safety and effectiveness of a Tai Chi-based cardiac rehabilitation programme for chronic coronary syndrom patients: study protocol for a randomised controlled trial.

BMJ Open 2020 Jul 5;10(7):e036061. Epub 2020 Jul 5.

College of Physical Education and Sports, Beijing Normal University, Beijing, China

Introduction: Preliminary evidence from clinical observations suggests that Tai Chi exercise may offer potential benefits for patients with chronic coronary syndrom (CCS). However, the advantages for CCS patients to practice Tai Chi exercise as rehabilitation have not been rigorously tested and there is a lack of consensus on its benefits. This study aims to develop an innovative Tai Chi Cardiac Rehabilitation Program (TCCRP) for CCS patients and to assess the efficacy, safety and acceptability of the programme. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036061DOI Listing

[Anxiety in neurological practice].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):165-170

Scientific Research Institute of General Pathology and Pathophysiology, Moscow, Russia.

Anxiety and related disorders are the most common type of mental disorders in both the general population and the neurological clinic. A current typology of anxiety disorders includes panic disorder, agoraphobia, simple (specific) phobias, social anxiety disorder, and generalized anxiety disorder. Anxiety disorders often accompany diseases of the nervous system, worsen their course and impede treatment, and the degree of anxiety usually corresponds to the severity of neurological symptoms. Read More

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http://dx.doi.org/10.17116/jnevro2020120051165DOI Listing
January 2020

Substance use disorders among youth with chronic physical illness.

Addict Behav 2020 Jun 23;110:106517. Epub 2020 Jun 23.

School of Public Health & Health Systems, University of Waterloo, Waterloo, Canada. Electronic address:

This study estimated prevalence of substance use disorder in youth with chronic physical illness; quantified magnitudes of association between different chronic physical illnesses with substance use disorder; and, tested whether mental disorder moderates these associations. Data come from 6,377 individuals aged 15-30 years in the Canadian Community Health Survey-Mental Health. Alcohol, cannabis, or other drug use disorder measured using the WHO Composite International Diagnostic Interview 3. Read More

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http://dx.doi.org/10.1016/j.addbeh.2020.106517DOI Listing

A Latent Class Analysis of Manic and Psychotic Symptoms.

J Nerv Ment Dis 2020 Jun 29. Epub 2020 Jun 29.

Université de Paris, NeuroDiderot, Inserm.

Bipolar spectrum disorders encompass heterogeneous clinical manifestations and comorbidities. A latent class analysis (LCA) was performed in 1846 subjects who experienced an episode of abnormally elevated or irritable mood to identify homogeneous groups of subjects, based on the distribution of 11 manic and 7 psychotic symptoms. LCA identified five classes: 1) two classes with irritability and with low and high level of psychosis (respectively "irritable," 29. Read More

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http://dx.doi.org/10.1097/NMD.0000000000001193DOI Listing

Use of a Mobile App to Augment Psychotherapy in a Community Psychiatric Clinic: Feasibility and Fidelity Trial.

JMIR Form Res 2020 Jul 3;4(7):e17722. Epub 2020 Jul 3.

Rose: Smarter Mental Health, Washington, DC, United States.

Background: Even though 1 in 5 Americans experience some form of mental illness each year, 80% have been shown to discontinue psychotherapy prematurely. The traditional psychotherapy service delivery model, consisting of isolated clinical sessions, lacks the ability to keep patients engaged outside clinical sessions. Newer digital mental health platforms can address the clinical need for a robust tool that tracks mental well-being and improves engagement in patients with depressive symptoms. Read More

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http://dx.doi.org/10.2196/17722DOI Listing

ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.

Hum Brain Mapp 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.

Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. Read More

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http://dx.doi.org/10.1002/hbm.25100DOI Listing
July 2020
5.969 Impact Factor

Mood, anxiety and olfactory dysfunction in COVID-19: evidence of central nervous system involvement?

Laryngoscope 2020 Jul 2. Epub 2020 Jul 2.

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH, USA, 45267.

Introduction: The objective of this study was to determine the burden of depressed mood and anxiety in COVID-19, and associated disease characteristics.

Materials And Methods: This is a prospective, cross-sectional study of 114 COVID-19 positive patients diagnosed using RT-PCR-based testing over a 6-week period. The 2-item Patient Health Questionnaire (PHQ-2) and the 2-item Generalized Anxiety Disorder questionnaire (GAD-2) were used to measure depressed mood and anxiety level, respectively, at enrollment and for participants' baseline, pre-COVID-19 state. Read More

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http://dx.doi.org/10.1002/lary.28964DOI Listing

Characterization and Prediction of Anxiety in Adolescents with Autism Spectrum Disorder: A Longitudinal Study.

J Abnorm Child Psychol 2020 Jul 2. Epub 2020 Jul 2.

The Autism Center, Department of Pediatrics, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel.

Anxiety is one of the most common comorbidities in youth with autism spectrum disorder (ASD). The current study's aims were: To examine the frequency of elevated anxiety symptoms in adolescents diagnosed with ASD in toddlerhood; To explore the impact of comorbid anxiety in adolescents on clinical presentation; To evaluate variables in toddlerhood that associate with anxiety symptom severity in adolescence. The study included 61 adolescents (mean age = 13:8y) diagnosed with ASD in toddlerhood (T1). Read More

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http://dx.doi.org/10.1007/s10802-020-00673-0DOI Listing

Attention Deficit Hyperactivity Disorder in Prisoners: Increased Substance Use Disorder Severity and Psychiatric Comorbidity.

Eur Addict Res 2020 Jul 2:1-12. Epub 2020 Jul 2.

Center for Evaluation and Sociomedical Research, Graduate School of Public Health, University of Puerto Rico, Rio Piedras, Puerto Rico, USA.

Objectives: Attention deficit hyperactivity disorder (ADHD) and substance use disorders (SUD) are overrepresented among incarcerated populations. We examined whether ADHD was associated with increased severity of comorbid SUD and with increased psychiatric comorbidity among prisoners.

Methods: Cross-sectional study of 500 randomly selected Latino male prisoners in the Puerto Rico Correctional System using validated diagnostic measures to assess Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) ADHD and SUD diagnosis, antisocial personality disorder (ASP) and borderline personality disorder (BPD), major depression, and generalized anxiety disorder (GAD). Read More

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http://dx.doi.org/10.1159/000508829DOI Listing

Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic.

JAMA Netw Open 2020 07 1;3(7):e2014053. Epub 2020 Jul 1.

Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, China.

Importance: People exposed to coronavirus disease 2019 (COVID-19) and a series of imperative containment measures could be psychologically stressed, yet the burden of and factors associated with mental health symptoms remain unclear.

Objective: To investigate the prevalence of and risk factors associated with mental health symptoms in the general population in China during the COVID-19 pandemic.

Design, Setting, And Participants: This large-sample, cross-sectional, population-based, online survey study was conducted from February 28, 2020, to March 11, 2020. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.14053DOI Listing

Psychometric Properties of the Generalized Anxiety Disorder Scale Among Saudi University Male Students.

Neuropsychiatr Dis Treat 2020 8;16:1427-1432. Epub 2020 Jun 8.

Department of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University (Mizan Campus), Mizan-Aman, Ethiopia.

Background: Various screening tools have been designed and developed to identify individuals with generalized anxiety disorder (GAD). The current study aimed to assess the psychometric validation of the GAD-7 in Saudi university male students.

Methods: Healthy university male students (n= 192) participated in this cross-sectional study. Read More

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http://dx.doi.org/10.2147/NDT.S246526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292258PMC

A systematic review of validated screening tools for anxiety disorders and PTSD in low to middle income countries.

BMC Psychiatry 2020 Jun 30;20(1):338. Epub 2020 Jun 30.

Department of Psychiatry, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC, 27514, USA.

Background: Anxiety and post-traumatic stress disorder (PTSD) contribute significantly to disability adjusted life years in low- to middle-income countries (LMICs). Screening has been proposed to improve identification and management of these disorders, but little is known about the validity of screening tools for these disorders. We conducted a systematic review of validated screening tools for detecting anxiety and PTSD in LMICs. Read More

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http://dx.doi.org/10.1186/s12888-020-02753-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325104PMC

Neurocognitive predictors of long-term outcome in CBT for late life generalized anxiety disorder.

Authors:
Jan Mohlman

J Anxiety Disord 2020 Jun 4;74:102246. Epub 2020 Jun 4.

William Paterson University, 300 Pompton Rd., Science Hall 250, Wayne, NJ, 07470, United States. Electronic address:

Generalized anxiety disorder (GAD) is currently recognized as one of the most common and impairing psychiatric conditions in adults age 65 and over. Although clinical trials have indicated that cognitive behavior therapy (CBT) is efficacious, it has not shown consistent superiority over other types of psychosocial interventions. This study sought to identify baseline neurocognitive predictors of posttreatment and distal follow-up outcome of CBT for late life GAD, which could be used to estimate response and optimize the intervention. Read More

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http://dx.doi.org/10.1016/j.janxdis.2020.102246DOI Listing

Relationship between disability and pain to post-traumatic stress disorder, depression, and anxiety in patient with postoperative brachial plexus injury (BPI).

Br J Neurosurg 2020 Jun 30:1-5. Epub 2020 Jun 30.

Departement of Psychiatry, Faculty of Medicine, Dr. Soetomo General Academic Hospital, Universitas Airlangga, Surabaya, Indonesia.

Orthopedic trauma patients have the risk to experience mental disorders, including depression, anxiety, post-traumatic stress disorder (PTSD), and other mental disorders. However, studies that analyze the relationship between mental disorders in orthopedic trauma patients, especially post-operative brachial plexus injury (BPI), are still difficult to find. This study aims to evaluate the relationship between disability and pain to post-traumatic stress disorder, depression, and anxiety in patient with postoperative BPI. Read More

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http://dx.doi.org/10.1080/02688697.2020.1784846DOI Listing

Do candidates for penile implant prefer their doctors or another implanted patient as their information source? Results of a pilot study.

Rev Int Androl 2020 Jun 26. Epub 2020 Jun 26.

Department of Urology, La Fe University Hospital, Valencia, Spain.

Introduction: Erectile dysfunction incidence is about 19-26 cases for every 1000 men/year, requiring about 20,000 penile implants/year. There is high demand for information on the part of patients, however, there is a lack of evidence about the sources of information prior to penile implant and the figure of the Expert Patient (EP) has never been described in this area.

Aims: To evaluate the sources of information used by candidates for penile implant as well as to describe the role of the EP as an information source. Read More

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http://dx.doi.org/10.1016/j.androl.2020.01.008DOI Listing

Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.

Hum Brain Mapp 2020 Jun 29. Epub 2020 Jun 29.

National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. Read More

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http://dx.doi.org/10.1002/hbm.25096DOI Listing
June 2020
5.969 Impact Factor

Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China.

Gen Psychiatr 2020 14;33(3):e100259. Epub 2020 Jun 14.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.

Background: Healthcare workers fighting against the coronavirus disease 2019 (COVID-19) pandemic are under tremendous pressure, which puts them at an increased risk of developing psychological problems.

Aims: This study aimed to investigate the prevalence of psychological problems in different healthcare workers (ie, physicians, medical residents, nurses, technicians and public health professionals) during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.

Methods: A cross-sectional, web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1136/gpsych-2020-100259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299004PMC

Prevalence and comorbidity of the ICD-11 and DSM-5 for PTSD caseness with previous diagnostic manuals among the Japanese population.

Eur J Psychotraumatol 2020 19;11(1):1753938. Epub 2020 May 19.

National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Tokyo, Japan.

: The diagnostic criteria for posttraumatic stress disorder (PTSD) differ between DSM-5 and ICD-11, which may affect the estimation of prevalence. : To investigate the concordance of ICD-11 and DSM-5, as compared to ICD-10 and DSM-IV, regarding PTSD caseness among Japanese people who had experienced different potentially traumatic events. In addition, we estimated the comorbidity with major depressive disorder and generalized anxiety disorder according to these four diagnostic manuals. Read More

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http://dx.doi.org/10.1080/20008198.2020.1753938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301694PMC

The influence of perinatal and maternal factors on physical growth at 12 months in prematurely born infants treated in the neonatal intensive care unit: A retrospective chart review and a prospective cohort study.

Int J Nurs Stud 2020 Jun 1;109:103656. Epub 2020 Jun 1.

School of Nursing, Shanghai Jiao Tong University, 227 South Chong Qing Road, Building 1, Room 213, Shanghai 200025, China. Electronic address:

Background: Growth retardation during the first year of life is frequently observed in prematurely born infants. Few reports have considered the effects of maternal emotional distress and perceptions of care burden on the outcomes of these infants.

Objectives: This study investigated the physical growth trajectories of prematurely born infants treated in neonatal intensive care unit and determined the effects of perinatal factors, maternal emotional distress and perceptions of care burden on growth retardation at 12 months' corrected age. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2020.103656DOI Listing

The immediate impact of the 2019 novel coronavirus (COVID-19) outbreak on subjective sleep status.

Sleep Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Psychology and Sleep, Nanjing Hospital of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China. Electronic address:

Background: An outbreak of the 2019 novel coronavirus (COVID-19) has been ongoing in China since January 2020. The threat of infection affects the work and life of most of the population and may also damage sleep. This study aims to examine the subjective sleep status and mental health of the population during the peak of the COVID-19 epidemic. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.05.018DOI Listing

Sleep quality and mood symptoms in conscripted frontline nurse in Wuhan, China during COVID-19 outbreak: A cross-sectional study.

Medicine (Baltimore) 2020 Jun;99(26):e20769

Mental health education center, the Second Military Medical University, Shanghai, China.

The aim of this study was to investigate the prevalence of sleep problems, depression and anxiety symptoms among conscripted frontline nurses fighting coronavirus disease 2019 (COVID-19) in Wuhan.This study was a cross-sectional study conducted with 100 frontline nurses. Sleep quality, depression, and anxiety symptoms were measured using the Pittsburgh sleep quality index (PSQI), the Generalized Anxiety Disorder 7-Item Scale (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9), respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000020769DOI Listing

Motor hyperactivation during cognitive tasks: An endophenotype of juvenile myoclonic epilepsy.

Epilepsia 2020 Jun 25. Epub 2020 Jun 25.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.

Objective: Juvenile myoclonic epilepsy (JME) is the most common genetic generalized epilepsy syndrome. Myoclonus may relate to motor system hyperexcitability and can be provoked by cognitive activities. To aid genetic mapping in complex neuropsychiatric disorders, recent research has utilized imaging intermediate phenotypes (endophenotypes). Read More

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http://dx.doi.org/10.1111/epi.16575DOI Listing

Using Generalized Anxiety Disorder-2 (GAD-2) and GAD-7 in a Primary Care Setting.

Cureus 2020 May 21;12(5):e8224. Epub 2020 May 21.

Family Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Anxiety disorders are highly prevalent in the primary care setting and are responsible for significant morbidity as well as a loss of productivity. Evaluation by mental health specialists and behavioral specialists can sometimes be confounded with problems of availability, accessibility, and the patient's hesitancy to talk to new providers due to lack of prior relationship and trust. Primary care providers already have the advantage of being available for their patients, and have built years of trust behind them to strengthen this relationship. Read More

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http://dx.doi.org/10.7759/cureus.8224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306644PMC

Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study.

Brain Behav 2020 Jun 24:e01730. Epub 2020 Jun 24.

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.

Background: The emergence of COVID-19 global pandemic coupled with high transmission rate and mortality has created an unprecedented state of emergency worldwide. This global situation may have a negative impact on the psychological well-being of individuals which in turn impacts individuals' performance. This study aims to explore the prevalence of depression and anxiety among the GP, HCPs, and USs during COVID-19 outbreak, and to identify key population(s) who might need psychological intervention. Read More

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http://dx.doi.org/10.1002/brb3.1730DOI Listing

Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice.

Brain 2020 Jun 24. Epub 2020 Jun 24.

Institute for Genomic Medicine, Columbia University, New York, NY, USA.

NMDA receptors play crucial roles in excitatory synaptic transmission. Rare variants in GRIN2A encoding the GluN2A subunit are associated with a spectrum of disorders, ranging from mild speech and language delay to intractable neurodevelopmental disorders, including but not limited to developmental and epileptic encephalopathy. A de novo missense variant, p. Read More

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http://dx.doi.org/10.1093/brain/awaa147DOI Listing

The Relationship between Physical Activity Levels and Mental Health in Individuals with Spinal Cord Injury in South Korea.

Int J Environ Res Public Health 2020 Jun 19;17(12). Epub 2020 Jun 19.

Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Seoul 03722, Korea.

The aim of this study was to assess the relationship between physical activity (PA) levels and mental health in individuals with spinal cord injury (SCI). Three hospitals in the Seoul metropolitan area were invited to recruit patients with SCI ( = 103). PA levels were measured by the Leisure Score Index of the Godin Leisure-Time Exercise Questionnaire (GLTEQ). Read More

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http://dx.doi.org/10.3390/ijerph17124423DOI Listing

Abnormal night sleep duration and inappropriate sleep initiation time are associated with elevated anxiety symptoms in Chinese rural adults: the Henan Rural Cohort.

Psychiatry Res 2020 Jun 15;291:113232. Epub 2020 Jun 15.

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, PR. China. Electronic address:

Sleep problems have been demonstrated to cause mental symptoms, such as anxiety. However, research on the association of the night sleep duration and sleep initiation time on anxiety symptoms in rural China is still lacking. The current study, therefore, explored the independent and combined association of the night sleep duration and sleep initiation time on anxiety symptoms. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113232DOI Listing

Online Mental Health Survey in a Medical College in China During the COVID-19 Outbreak.

Front Psychiatry 2020 13;11:459. Epub 2020 May 13.

Department of Radiology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Background: The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, Hubei province, has led to the quarantine of many residents in their homes, in order to mitigate its spread. Some of these people developed mental health problems, and many solutions have been put in place to address the mental health issues of patients and health professionals affected by the disease. However, not much attention has been given to students, particularly those from medical school. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237734PMC

Effects of a forehead cooling device in veterans with chronic insomnia disorder and co-morbid medical and psychiatric conditions: a pilot study.

Sleep Breath 2020 Jun 22. Epub 2020 Jun 22.

Ebb Therapeutics, 2555 Smallman Street Suite 100, Pittsburgh, PA, 15222, USA.

Purpose: While forehead cooling has been studied in patients with insomnia in the absence of comorbid medical/psychiatric disorders, it has never been evaluated in patients with insomnia in the presence of co-morbid medical/psychiatric disorders.

Methods: Veterans with chronic insomnia disorder and co-morbid medical and psychiatric conditions received 4-week open-label, in-home, nightly treatment with a forehead cooling device (14-16 °C) along with personalized sleep hygiene following baseline assessments. Pre- and post-treatment, participants completed the Insomnia Severity Index (ISI), the Generalized Anxiety Disorder 7-item scale (GAD-7), and the Patient Health Questionnaire 9-item scale (PHQ-9). Read More

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http://dx.doi.org/10.1007/s11325-020-02126-wDOI Listing

Cerebral Neurovascular Coupling Impairment in Central Serous Chorioretinopathy.

Ophthalmic Res 2020 Jun 19. Epub 2020 Jun 19.

Background Central serous chorioretinopathy (CSCR) is a chorioretinal disorder resulting from choroidal hyperpermeability. Its comorbidities as hypertension, coronary disease and psychological stress, suggest that it might reflect a more generalized vascular dysfunction. Objectives To assess the cerebrovascular regulation integrity, using cerebral autoregulation (CA), carbon dioxide vasoreactivity (VR) and neurovascular coupling (NVC) in CSCR. Read More

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http://dx.doi.org/10.1159/000509553DOI Listing

Vulvar pain: The revealing scenario of leading comorbidities in 1183 cases.

Eur J Obstet Gynecol Reprod Biol 2020 May 30;252:50-55. Epub 2020 May 30.

ASP 7, Ragusa Hospital, Italy.

Objectives: This study set out to investigate the epidemiological characteristics and comorbidities of chronic vulvar pain. Secondary goals were to identify the preferred approaches for managing vulvodynia in Italy.

Study Design: A cross-sectional study (the VuNet -Vulvodynia Network project) was performed in consecutive female patients with chronic vulvar pain attending 21 Italian medical centers (public hospitals, university clinics and private outpatient services) in the period December 2016 to November 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.052DOI Listing

Molecularly Defined Hippocampal Inputs Regulate Population Dynamics in the Prelimbic Cortex to Suppress Context Fear Memory Retrieval.

Biol Psychiatry 2020 Apr 28. Epub 2020 Apr 28.

Lieber Institute for Brain Development, Baltimore, Maryland; Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Background: Context fear memory dysregulation is a hallmark symptom of several neuropsychiatric disorders, including generalized anxiety disorder and posttraumatic stress disorder. The hippocampus (HC) and prelimbic (PrL) subregion of the medial prefrontal cortex have been linked with context fear memory retrieval in rodents, but the mechanisms by which HC-PrL circuitry regulates this process remain poorly understood.

Methods: Spatial and genetic targeting of HC-PrL circuitry was used for RNA sequencing (n = 31), chemogenetic stimulation (n = 44), in vivo calcium imaging (n = 20), ex vivo electrophysiology (n = 8), and molecular regulation of plasticity cascades during fear behavior (context fear retrieval) (n = 16). Read More

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http://dx.doi.org/10.1016/j.biopsych.2020.04.014DOI Listing

Mental disorders in Spanish university students: Prevalence, age-of-onset, severe role impairment and mental health treatment.

J Affect Disord 2020 Aug 11;273:604-613. Epub 2020 May 11.

Health Services Research Group, IMIM (Institut Hospital del Mar d´Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Pompeu Fabra University (UPF), Barcelona, Spain. Electronic address:

Background: The university period carries risk for onset of common mental disorders. Epidemiological knowledge on mental disorders among Spanish university students is limited.

Aims: To estimate lifetime and 12-month prevalence, persistence and age-of-onset of mental disorders among Spanish first-year university students, as well as associated role impairment and mental health treatment use. Read More

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http://dx.doi.org/10.1016/j.jad.2020.04.050DOI Listing

How do worry and clinical status impact working memory performance? An experimental investigation.

BMC Psychiatry 2020 Jun 19;20(1):317. Epub 2020 Jun 19.

Department of Psychology, Psychological Interventions and Psychotherapy, University of Zurich, Zurich, Switzerland.

Background: Previous research has suggested that worry is negatively associated with working memory performance. However, it is unclear whether these findings would replicate across different worry levels and in individuals with anxiety and depressive disorders (i.e. Read More

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http://dx.doi.org/10.1186/s12888-020-02694-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304094PMC

Increased dehydroepiandrosterone (DHEA) is associated with anxiety in adolescent girls.

Psychoneuroendocrinology 2020 Jun 7;119:104751. Epub 2020 Jun 7.

Florida State University Department of Psychology Tallahassee, FL 32304, United States.

The pubertal period is a time of rapid increase in the incidence of anxiety disorders, and thus, pubertal hormones may play a role in the precipitation of anxious psychopathology. DHEA, a steroid hormone that surges in adolescence, has been previously linked to anxiety, although the direction of this effect has been mixed. Using a cross-sectional design in a sample of 286 adolescent girls, the present study examined associations between salivary DHEA concentrations and self-report and interview-based measures of anxiety while controlling for pubertal status, menarche status, assessment time of day, and other hormones including testosterone, estradiol, and progesterone. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2020.104751DOI Listing

The contribution of mindfulness to outpatient substance use disorder treatment in Brazil: a preliminary study.

Braz J Psychiatry 2020 Jun 12. Epub 2020 Jun 12.

Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Objective: To explore the contribution of a mindfulness-based intervention as an adjuvant to outpatient substance use disorder treatment. Outcomes included substance use behavior, depression and anxiety symptoms, and anger expression.

Methods: This preliminary study for a pragmatic randomized controlled trial with stratified random allocation included three months of follow-up. Read More

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http://dx.doi.org/10.1590/1516-4446-2019-0725DOI Listing

Risk perception in paranoia and anxiety: Two investigations across clinical and non-clinical populations.

Schizophr Res Cogn 2020 Sep 29;21:100176. Epub 2020 Mar 29.

Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.

Objectives: It is common, among clinical and non-clinical populations alike, for paranoia and anxiety to co-occur. It has been suggested that anxiety and its related appraisal styles may contribute to development of paranoia. We aimed to evaluate different aspects of risk perception in relation to paranoia and anxiety and to identify specific aspects that may differentiate paranoia from anxiety. Read More

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http://dx.doi.org/10.1016/j.scog.2020.100176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284287PMC
September 2020

High Rates of Mental Health Disorders in Civilian Employees Working in Police Organizations.

Front Psychol 2020 28;11:1031. Epub 2020 May 28.

Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Working in a police organization often involves being exposed to potentially traumatic events and stressful circumstances regardless of occupation or rank. Police mental health is a public health concern, but the mental health of civilian employees working in police organizations has been much less studied. The current study aims to compare the frequency of mental health conditions in both police officers and civilians. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270335PMC

Parsing differences in amygdala volume among individuals with and without social and generalized anxiety disorders across the lifespan.

J Psychiatr Res 2020 May 30;128:83-89. Epub 2020 May 30.

University of Illinois at Chicago; Department of Psychiatry, 1603 W. Taylor, Chicago, IL, 60612, USA.

Structural differences in the amygdala (AMG) are implicated in anxiety and observed among individuals with generalized (GAD) and social anxiety (SAD) disorders. Findings have been mixed, perhaps because studies rarely examine differences between GAD and SAD, test comorbidity, or examine age-related differences. We tested AMG volume differences among a sample of adults and youth with/without SAD and GAD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.05.027DOI Listing

Trauma related psychiatric disorders and their correlates in a clinical sample: A cross-sectional study in trauma affected patients visiting a psychiatric clinic in Nepal.

PLoS One 2020 15;15(6):e0234203. Epub 2020 Jun 15.

Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Nepal, like many other low-income countries, has a great burden of mental health issues but few resources to meet them. In addition, Nepal has endured several traumatic events in recent decades but the impact on mental health has not been studied in clinical settings. This study explores trauma-related psychiatric disorders and their correlates. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234203PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295578PMC

Challenging the negative learning bias hypothesis of depression: reversal learning in a naturalistic psychiatric sample.

Psychol Med 2020 Jun 15:1-11. Epub 2020 Jun 15.

Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Classic theories posit that depression is driven by a negative learning bias. Most studies supporting this proposition used small and selected samples, excluding patients with comorbidities. However, comorbidity between psychiatric disorders occurs in up to 70% of the population. Read More

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http://dx.doi.org/10.1017/S0033291720001956DOI Listing

An integrated sleep and anxiety intervention for anxious children: A pilot randomized controlled trial.

Clin Child Psychol Psychiatry 2020 Jun 13:1359104520933936. Epub 2020 Jun 13.

Department of Psychology, University of Houston, USA.

Sleep-related complaints hold complex reciprocal relationships with anxiety and are a pervasive, distressing feature of childhood generalized anxiety disorders (GAD). Although evidence suggests purely anxiety-focused treatments reduce some sleep problems of anxious children, interventions that directly target both anxiety and sleep might produce superior outcomes in both domains. Targeted Behavioral Therapy (TBT), developed for co-morbid sleep and anxiety problems, demonstrated initial efficacy in a small case series but has not been directly compared to anxiety-focused treatment. Read More

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http://dx.doi.org/10.1177/1359104520933936DOI Listing

Prevalence and Factors Associated with Insomnia Among a Representative Sample of the Lebanese Population: Results of a Cross-Sectional Study.

J Epidemiol Glob Health 2020 Jun;10(2):124-130

Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.

The objectives of the study were to identify the prevalence of insomnia among a representative sample of the Lebanese population and to assess potential factors associated with insomnia among this group. A cross-sectional study was done in the Lebanese population from August 2017 to April 2018 enrolling 789 participants using a proportionate random sample from all five Lebanese governorates. Participants filled a self-administered Arabic questionnaire. Read More

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http://dx.doi.org/10.2991/jegh.k.200117.001DOI Listing

A randomized controlled study of weighted chain blankets for insomnia in psychiatric disorders.

J Clin Sleep Med 2020 Jun 15. Epub 2020 Jun 15.

The Affective Disorder Outpatient Clinic at Psychiatry Southwest, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Study Objectives: This study aimed to evaluate the effect of weighted chain blankets on insomnia and sleep-related daytime symptoms for patients with major depressive disorder, bipolar disorder, generalized anxiety disorder (GAD) and attention deficit hyperactivity disorder (ADHD).

Methods: One hundred twenty patients were randomized (1:1) to either a weighted metal chain blanket or a light plastic chain blanket for four weeks. The outcome was evaluated using the Insomnia Severity Index (ISI) as primary outcome measure and the Day and Night Diaries (DND), Fatigue Symptom Inventory (FSI), and Hospital Anxiety and Depression Scale (HADS) as secondary outcome measures. Read More

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http://dx.doi.org/10.5664/jcsm.8636DOI Listing

Long-Term Mental Health Effects of a Devastating Wildfire Are Amplified by Sociodemographic and Clinical Antecedents in College Students.

Disaster Med Public Health Prep 2020 Jun 15:1-11. Epub 2020 Jun 15.

Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Objectives: The aim of this study is to assess prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD) in students of Keyano College 18 months after a wildfire and to determine the predictors of likely MDD, GAD, and PTSD in the respondents.

Methods: A quantitative cross-sectional survey was used to collect data through self-administered, paper-based questionnaires to determine likely MDD, GAD, and PTSD using the PHQ 9, GAD-7, and the PTSD Checklist for DSM 5, Part 3, respectively. Data were analyzed with SPSS version 20 (IBM Corp, Armonk, NY) using univariate analysis with chi-square tests. Read More

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http://dx.doi.org/10.1017/dmp.2020.87DOI Listing

Brief Report: Asexuality and Young Women on the Autism Spectrum.

J Autism Dev Disord 2020 Jun 13. Epub 2020 Jun 13.

Independent Practice, 50 Grove St., 2nd Floor, Arlington, MA, 02476, USA.

Existing research suggests that people with Autism Spectrum Disorder (ASD) are more likely than those without ASD to self-identify as asexual, or as being on the asexual spectrum. This study contributes to the literature by exploring aspects of sexuality and well-being in a large, community-based sample of young women (18-30 years old) with ASD (N = 247) and comparing the experiences of those with asexual spectrum identities and those with other sexual orientations (e.g. Read More

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http://dx.doi.org/10.1007/s10803-020-04565-6DOI Listing

Patient and Family Engagement in Care in the Cardiac Intensive Care Unit.

Can J Cardiol 2020 Mar 31. Epub 2020 Mar 31.

Division of Critical Care Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Hospitalization in the cardiac intensive care unit can be a stressful experience for patients and families. Family members often feel overwhelmed by the severity of their loved one's illness, powerless to affect their care, and struggle to comprehend information regarding their loved one's current health status and treatment plan. Consequently, up to half of family members might develop psychological symptoms (depression, generalized anxiety, and post-traumatic stress disorder) and a syndrome of enduring psychological, cognitive, or emotional disturbances. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.03.037DOI Listing

Two-way messaging therapy for depression and anxiety: longitudinal response trajectories.

BMC Psychiatry 2020 Jun 12;20(1):297. Epub 2020 Jun 12.

New York University Grossman School of Medicine, New York, USA.

Background: Telemedicine is a strategy for overcoming barriers to access evidence-based psychotherapy. Digital modalities that operate outside session-based treatment formats, such as ongoing two-way messaging, may further address these challenges. However, no study to date has established suitability criteria for this medium. Read More

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http://dx.doi.org/10.1186/s12888-020-02721-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291694PMC