128,471 results match your criteria Generalized Anxiety Disorder


Chasing red herrings: Can visual distracters extend the time children take to open child resistant vials?

PLoS One 2018 12;13(12):e0207738. Epub 2018 Dec 12.

School of Packaging, Michigan State University, East Lansing, MI, United States of America.

Background: Unintentional exposure to medications is a noted problem in pediatric populations despite the prevalent use of child-resistant (CR) packaging and educational campaigns informing consumers about appropriate storage.

Objective: Conduct a proof-of concept study that evaluates how package designs that engage the attention of children in meaningless ways affect opening time and number of openings.

Study Design: Non-CR vials with or without distracters were provided to 108 children (24-51 months) in pairs. Read More

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December 2018

Prediction of Membrane Permeation of Drug Molecules by Combining an Implicit Membrane Model with Machine Learning.

J Chem Inf Model 2018 Dec 12. Epub 2018 Dec 12.

Lipid membrane permeation of drug molecules was investigated with Heterogeneous Dielectric Generalized Born (HDGB) based models using solubility-diffusion theory and machine learning. Free energy profiles were obtained for neutral molecules by the standard HDGB and Dynamic HDGB (DHDGB) to account for the membrane deformation upon insertion of drugs. We also obtained hybrid free energy profiles where the neutralization of charged molecules was taken into account upon membrane insertion. Read More

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December 2018

Obesity and healthy aging: social, functional and mental well-being among older Canadians.

Health Promot Chronic Dis Prev Can 2018 Dec;38(12):437-444

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: Canadians are living longer than before, and a large proportion of them are living with obesity. The present study sought to describe how older participants in the Canadian Longitudinal Study on Aging (CLSA) who are living with obesity are aging, through an examination of measures of social, functional and mental well-being.

Methods: We used data from the first wave of the CLSA for people aged 55 to 85 years in this study. Read More

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December 2018
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Variation in the prevalence and abundance of acanthocephalans in brown-nosed coatis Nasua nasua and crab-eating foxes Cerdocyon thous in the Brazilian Pantanal.

Braz J Biol 2018 Dec 10. Epub 2018 Dec 10.

Laboratório de Biologia e Parasitologia de Mamíferos Silvestre Reservatórios, Instituto Oswaldo Cruz - IOC, Fundação Oswaldo Cruz - FIOCRUZ, Avenida Brasil, 4365, Manguinhos, CEP 21045-900, Rio de Janeiro, RJ, Brasil.

Host infection by parasites is influenced by an array of factors, including host and environmental features. We investigated the relationship between host sex, body size and age, as well as seasonality on infection patterns by acanthocephalan in coatis (Procyonidae: Nasua nasua) and in crab-eating foxes (Canidae: Cerdocyon thous ) from the Brazilian Pantanal wetlands. Between 2006 and 2009, we collected faecal samples from these hosts and analyzed for the presence of acanthocephalan eggs. Read More

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December 2018

INSULIN RESISTANCE REDUCTION AFTER SUSTAINED VIROLOGICAL RESPONSE WITH DIRECT ACTING ANTIVIRAL:NOT EVERY POPULATION IMPROVES.

Arq Gastroenterol 2018 Jul-Sep;55(3):274-278

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Clínica Médica, Botucatu, SP, Brasil.

Background: Hepatitis C virus (HCV) infection is a serious public health problem, that affects approximately 170 million people worldwide. Chronic HCV infection is associated with hepatic insulin resistance and an increased risk of diabetes HCV-infected patients has been well documented.

Objective: To assess the homeostasis model assessment of insulin resistance (HOMA-IR) index in patients treated with direct acting antiviral (DAAs) medication in the sustained virological response (SVR), categorized by the presence or absence of cirrhosis. Read More

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VITAMIN D DEFICIENCY AND PARATOHOMMONIUM INCREASE IN LATE POSTOPERATIVE GASTRIC BYPASS IN ROUX-EN-Y.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1407. Epub 2018 Dec 6.

Lane Clinic, Campinas, SP, Brazil.

Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency.

Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up.

Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. Read More

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December 2018

New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

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December 2018

Idiopathic "Cyclic" Edema: a Frustrating and Poorly Understood Clinical Problem.

Cardiovasc Hematol Agents Med Chem 2018 Dec 11. Epub 2018 Dec 11.

Gill Heart and Vascular Institute University of Kentucky Lexington, Kentucky. United States.

Idiopathic edema (IE), is a syndrome involving real or perceived weight gain secondary to the pathological retention of fluid. This syndrome of generalized edema is almost solely reported in women. The diagnosis of IE is one of exclusion and requires a careful history, physical exam, and clinical suspicion. Read More

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December 2018

Multiple Equilibria in a Non-smooth Epidemic Model with Medical-Resource Constraints.

Bull Math Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.

The issue of medical-resource constraints has the potential to dramatically affect disease management, especially in developing countries. We analyze a non-smooth epidemic model with nonlinear incidence rate and resource constraints, which defines a vaccination program with vaccination rate proportional to the number of susceptible individuals when this number is below the threshold level and constant otherwise. To better understand the impact of this non-smooth vaccination policy, we provide a comprehensive qualitative analysis of global dynamics for the whole parameter space. Read More

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December 2018

Association of Early Life Exposure to Phthalates With Obesity and Cardiometabolic Traits in Childhood: Sex Specific Associations.

Front Public Health 2018 27;6:327. Epub 2018 Nov 27.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.

Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age. Read More

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November 2018

Incorporating Interview-Informed Functional Analyses into Practice.

Behav Anal Pract 2018 Dec 20;11(4):385-389. Epub 2018 Apr 20.

ABACS, Woburn, MA USA.

We replicated and extended the effects of an assessment and treatment model employed by Hanley et al. (, , 16-36, 2014) with one participant receiving home-based services. Following a functional analysis, we taught the participant multiple functional communication responses (FCRs) and to tolerate delays and denials to requested items. Read More

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December 2018

The Use of a Multicomponent Behavioral Intervention to Promote Physical Activity in Adolescents with Autism Spectrum Disorders across Inclusive Community Settings.

Behav Anal Pract 2018 Dec 27;11(4):358-369. Epub 2018 Sep 27.

Technology Enhanced Learning and Living (TELL), 314 E. Highland Mall Blvd #112, Austin, TX 78752 USA.

Individuals with autism spectrum disorder (ASD) are generally less physically active than individuals without disability due to factors such as lack of motor coordination and inadequate transportation resources that can result in various barriers to participation. This affects their independence and may interfere with expectations (e.g. Read More

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December 2018

Promoting Generalized Advanced Language Skills of Children in Intensive Behavioral Intervention with Promoting the Emergence of Advanced Knowledge Generalization Module (PEAK-G).

Behav Anal Pract 2018 Dec 26;11(4):289-306. Epub 2018 Jan 26.

3Rehabilitation Institute, Southern Illinois University, Carbondale, IL USA.

The Promoting the Emergence of Advanced Knowledge Relational Training System Generalization Module (PEAK-G; Dixon, 2014) was used within a community-based intensive behavioral intervention (IBI) program to enhance the generalized advanced language skills of children diagnosed with autism spectrum disorder. Four multiple-baseline, across-behaviors designs were used to assess the effectiveness of the PEAK-G "train and test" discrete trial training (DTT) method on directly trained and generalized language skills. After implementing PEAK-G, directly trained language skills increased for all participants, and generalization to test stimuli was observed for two participants, with some generalization observed for a third participant. Read More

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December 2018

Teaching Children with Autism to Initiate and Respond to Peer Mands Using Picture Exchange Communication System (PECS).

Behav Anal Pract 2018 Dec 30;11(4):279-288. Epub 2018 Oct 30.

Play and Language Support (PALS) preschool, Unit 18, Northwest Business Park, Blanchardstown, Dublin, 15 Ireland.

We evaluated the effects of systematic prompting plus reinforcement on listeners' independent responses to peer mands and on speakers' peer-directed mands using the picture exchange communication system (PECS) in two studies. In Study 1, three PECS users with a diagnosis of autism were trained to direct PECS exchanges toward peers, whereas in Study 2, three peers with autism were taught to accept a PECS card, select the requested item from an array of three items, and place it in front of their peer. Study 1 showed an increase in peer PECS mands that generalized to novel trained peers for all participants. Read More

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December 2018

Impact of Physical and Cognitive Exertion on Cognitive Control.

Front Psychol 2018 27;9:2369. Epub 2018 Nov 27.

LAMHESS, Université Côte d'Azur, Nice, France.

In a recent study, the differential effects of prolonged physiologically challenging exercise upon two executive processes (cognitive control and working memory) were investigated. However, the impact of exercise on the selective inhibition task employed was debatable and needed further analysis to dissociate the effects induced by exercise intensity from those induced by the time spent on task upon cognitive control outcomes. In this study, we propose a thorough analysis of these data, using a generalized mixed model on a trial-by-trial basis and a new measure of the strength of the automatic response based on reaction time distribution, to disentangle the effect of physical fatigue from cognitive fatigue. Read More

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November 2018

Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.

Front Synaptic Neurosci 2018 27;10:43. Epub 2018 Nov 27.

Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Understanding the long term impact of early life seizures (ELS) is of vital importance both for researchers and clinicians. Most experimental studies of how seizures affect the developing brain have drawn their conclusions based on changes detected at the cellular or behavioral level, rather than on intermediate levels of analysis, such as the physiology of neuronal networks. Neurons work as part of networks and network dynamics integrate the function of molecules, cells and synapses in the emergent properties of brain circuits that reflect the balance of excitation and inhibition in the brain. Read More

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November 2018

Dose-Dependent Effects of Closed-Loop tACS Delivered During Slow-Wave Oscillations on Memory Consolidation.

Front Neurosci 2018 27;12:867. Epub 2018 Nov 27.

Center for Human-Machine Collaboration, Information and Systems Sciences Laboratory, HRL Laboratories, LLC, Malibu, CA, United States.

Sleep is critically important to consolidate information learned throughout the day. Slow-wave sleep (SWS) serves to consolidate declarative memories, a process previously modulated with open-loop non-invasive electrical stimulation, though not always effectively. These failures to replicate could be explained by the fact that stimulation has only been performed in open-loop, as opposed to closed-loop where phase and frequency of the endogenous slow-wave oscillations (SWOs) are matched for optimal timing. Read More

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November 2018

Brain structural networks and connectomes: the brain-obesity interface and its impact on mental health.

Neuropsychiatr Dis Treat 2018 26;14:3199-3208. Epub 2018 Nov 26.

Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan,

Purpose: Obesity is a complex and multifactorial disease identified as a global epidemic. Convergent evidence indicates that obesity differentially influences patients with neuropsychiatric disorders providing a basis for hypothesizing that obesity alters brain structure and function associated with the brain's propensity toward disturbances in mood and cognition. Herein, we characterize alterations in brain structures and networks among obese subjects (ie, body mass index [BMI] ≥30 kg/m) when compared with non-obese controls. Read More

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November 2018

Multiple Gastrointestinal Cancers in a Single Patient-a Rare Clinical Entity.

Indian J Surg Oncol 2018 Dec 16;9(4):633-635. Epub 2018 May 16.

Department of Surgical Oncology, BLK Hospital, Rajinder Place, New Delhi, 110008 India.

Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Read More

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December 2018

External validation of a bifactor model of oppositional defiant disorder.

Mol Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychology, University of Connecticut, Storrs, CT, USA.

Dimensions of irritability and defiant behavior, though correlated within the structure of ODD, convey separable developmental risks through adolescence and adulthood. Irritability predicts depression and anxiety, whereas defiant behavior is a precursor to antisocial outcomes. Previously we demonstrated that a bifactor model comprising irritability and defiant behavior dimensions, in addition to a general factor, provided the best-fitting structure of ODD symptoms in five large datasets. Read More

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December 2018

Geographical-level contributions of risk factors for HIV infections using generalized additive models: results from a cohort of South African women.

AIDS Care 2018 Dec 11:1-9. Epub 2018 Dec 11.

b HIV Prevention Research Unit , South African Medical Research Council , Westville , South Africa.

South Africa has the highest burden of human immunodeficiency virus (HIV) infections in the world with significant geographical variations. We identified the predictors of HIV infections and their sub-geographical-level contributions to the epidemic using a decade long data (2002-2012) from 6484 South African women. Generalized additive models were used to uncover the most significant features of these estimates across the region. Read More

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December 2018

Reverse remodeling of pulmonary arteries by high-dose prostaglandin I therapy: A case report.

J Cardiol Cases 2014 May 2;9(5):173-176. Epub 2014 Feb 2.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Idiopathic pulmonary arterial hypertension (IPAH) is characterized by pulmonary vascular remodeling. We have reported that high-dose prostaglandin I (PGI) therapy markedly improved hemodynamics in IPAH patients and that PGI induced apoptosis of pulmonary artery smooth muscle cells obtained from IPAH patients. PGI is thought to have reverse remodeling effects, although it has not been histologically confirmed. Read More

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Complete congenital absence of the pericardium: An incidental finding.

J Cardiol Cases 2013 Nov 26;8(5):148-150. Epub 2013 Sep 26.

Cardiovascular Department, Blackpool Victoria Hospital, Whinney Heys Road, Blackpool FY3 8NR, United Kingdom.

A 62-year-old male presented with generalized aches and pains accompanied by night sweats and weight loss. Clinical examination was unremarkable and the chest X-ray was reported as normal. Subsequent computed-tomography thorax and bone marrow aspirate diagnosed a diffuse large B-cell lymphoma. Read More

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November 2013

A case of idiopathic ventricular fibrillation in which implanted loop recorder was useful in application decision for implantation of implantable cardioverter-defibrillator.

J Cardiol Cases 2012 Aug 20;6(2):e59-e63. Epub 2012 Jun 20.

Division of Cardiology, Department of Internal Medicine, Uwajima City Hospital, Goten-machi 1-1, Uwajima, Ehime 798-8510, Japan.

Establishing a symptom-rhythm correlation in patients with unexplained syncope is complicated because of its sporadic, infrequent, and unpredictable nature. Recently, an implantable loop recorder (ILR) has become available to evaluate undiagnosed recurrent arrhythmic episodes particularly in unexplained syncopes, and its usefulness has been reported in patients with recurrent syncopes that remain unexplained after conventional work-up. A 65-year-old man was referred to our hospital for loss of consciousness with nocturnal paroxysmal seizures. Read More

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The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):358-370. Epub 2018 Dec 11.

Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More

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December 2018
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Progression of Hearing Loss in the Aging Population: Repeated Auditory Measurements in the Rotterdam Study.

Audiol Neurootol 2018 Dec 11;23(5):290-297. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

We quantified changes in the auditory acuity of 675 aging adults (mean age 71.1 years, 52.0% female, mean follow-up 4. Read More

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December 2018

Feature selection and tumor classification for microarray data using relaxed Lasso and generalized multi-class support vector machine.

J Theor Biol 2018 Dec 8. Epub 2018 Dec 8.

College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address:

At present, the study of gene expression data provides a reference for tumor diagnosis at the molecular level. It is a challenging task to select the feature genes related to the classification from the high-dimensional and small-sample gene expression data and successfully separate the different subtypes of tumor or the normal from the patient. In this paper, we present a new method for tumor classification-relaxed Lasso (least absolute shrinkage and selection operator) and generalized multi-class support vector machine (rL-GenSVM). Read More

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December 2018

Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture.

Biotechnol J 2018 Nov 22:e1800376. Epub 2018 Nov 22.

Department of Chemical Engineering, Faculty of Engineering, Imperial College London, London, UK.

To stop the spread of future epidemics and meet infant vaccination demands in low- and middle-income countries, flexible, rapid and low-cost vaccine development and manufacturing technologies are required. Vaccine development platform technologies that can produce a wide range of vaccines are emerging, including: a) humanized, high-yield yeast recombinant protein vaccines; b) insect cell-baculovirus ADDomer vaccines; c) Generalized Modules for Membrane Antigens (GMMA) vaccines; d) RNA vaccines. Herein, existing and future platforms are assessed in terms of addressing challenges of scale, cost, and responsiveness. Read More

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November 2018
1 Read

Estimating marginal proportions and intraclass correlations with clustered binary data.

Biom J 2018 Dec 11. Epub 2018 Dec 11.

Biostatistics, Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain.

A logistic regression with random effects model is commonly applied to analyze clustered binary data, and every cluster is assumed to have a different proportion of success. However, it could be of interest to obtain the proportion of success over clusters (i.e. Read More

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December 2018

Initiation and interruption in intravenous bisphosphonate therapy among patients with multiple myeloma in the United States.

Cancer Med 2018 Dec 8. Epub 2018 Dec 8.

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Prior to 2018, intravenous bisphosphonates (IV BPs) were the only therapies recommended to prevent skeletal-related events for patients diagnosed with multiple myeloma (MM). We examined patterns of IV BP initiation and interruption among patients with newly diagnosed MM (NDMM) in the United States.

Methods: Electronic health records linked to administrative health insurance claims were used to identify adults with NDMM between 1 January 2011 and 30 April 2016. Read More

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December 2018

A new method to quantify mandibular corpus shape in extant great apes and its potential application to the hominoid fossil record.

Am J Phys Anthropol 2018 Dec 7. Epub 2018 Dec 7.

Department of Anthropology, University of Toronto, St. Toronto, Ontario, Canada.

Objectives: Mandibular corpus robusticity (corpus breadth/corpus height) is the most commonly utilized descriptor of the mandibular corpus in the great ape and hominin fossil records. As a consequence of its contoured shape, linear metrics used to characterize mandibular robusticity are inadequate to quantify the shape of the mandibular corpus. Here, we present an alternative to the traditional assessment of mandibular shape by analyzing the outline of the mandibular corpus in cross-section using landmarks and semilandmarks. Read More

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December 2018

Propensity-score-based priors for Bayesian augmented control design.

Pharm Stat 2018 Dec 9. Epub 2018 Dec 9.

Division of Biostatistics, Center for Devices and Radiological Health, Food, and Drug Administration, Silver Spring, Maryland, USA.

Drug developers are required to demonstrate substantial evidence of effectiveness through the conduct of adequate and well-controlled (A&WC) studies to obtain marketing approval of their medicine. What constitutes A&WC is interpreted as the conduct of randomized controlled trials (RCTs). However, these trials are sometimes unfeasible because of their size, duration, and cost. Read More

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December 2018
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Gingival crevicular fluid and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease.

J Periodontol 2018 Dec 11. Epub 2018 Dec 11.

Department of Periodontology, Faculty of Dentistry, Ege University, İzmir, Turkey.

Aim: Hypoxia-inducible factor-1 alpha (HIF-1α) is expressed as an adaptive response to hypoxia, mediates angiogenesis through the expression of vascular endothelial growth factor (VEGF) and can be induced by tumor necrosis factor-alpha (TNF-α). This study aimed to investigate the gingival crevicular fluid (GCF) and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease.

Methods: A total of 87 individuals, 20 generalized aggressive periodontitis (G-AgP), 20 chronic periodontitis (CP), 26 gingivitis patients, and 21 periodontally healthy individuals, were included. Read More

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December 2018

Maximum likelihood estimation of generalized linear models for adaptive designs: Applications and asymptotics.

Biom J 2018 Dec 10. Epub 2018 Dec 10.

Department of Mathematics and Statistics, Memorial University, St. John's, NL, Canada.

Due to increasing discoveries of biomarkers and observed diversity among patients, there is growing interest in personalized medicine for the purpose of increasing the well-being of patients (ethics) and extending human life. In fact, these biomarkers and observed heterogeneity among patients are useful covariates that can be used to achieve the ethical goals of clinical trials and improving the efficiency of statistical inference. Covariate-adjusted response-adaptive (CARA) design was developed to use information in such covariates in randomization to maximize the well-being of participating patients as well as increase the efficiency of statistical inference at the end of a clinical trial. Read More

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December 2018

Reduced prevalence of alcoholic gastritis in hospitalized individuals who consume cannabis.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Background: Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co-used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. However, no clinical study has examined the impact of cannabis use on the development of alcoholic gastritis among risky alcohol users. Read More

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December 2018
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Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures.

Epilepsia 2018 Dec 9. Epub 2018 Dec 9.

Department of Electrical and Electronic Engineering, The University of Melbourne, Melbourne, Victoria, Australia.

Objective: To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNES.

Methods: In this study, motor data were recorded using wrist-worn ACM-based devices. Read More

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December 2018

[Mobile applications related to multiple sclerosis: a systematic review].

Rev Neurol 2018 Dec;67(12):473-483

Universidad Rey Juan Carlos, 28922 Alcorcon, Espana.

Introduction: New treatment options are emerging within the information and communication technologies field through smartphones in order to treat multiple sclerosis (MS) patients.

Aim: To carry out a systematic review about the information related to mobile applications specifically designed in the field of MS, in order to classify them and carry out a description of their main characteristics.

Subjects And Methods: A literature search of articles published in English and Spanish has been carried out from 2012 until 2017 that presents, analyzes and validates a system based on an application with utility or specific design for MS. Read More

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December 2018

The Role of Culture of Origin on the Effectiveness of a Parents-Involved Intervention to Prevent Substance Use Among Latino Middle School Youth: Results of a Cluster Randomized Controlled Trial.

Prev Sci 2018 Dec 8. Epub 2018 Dec 8.

Global Center for Applied Health Research (GCAHR), Arizona State University, Phoenix, AZ, USA.

The purpose of this study was to assess the combined effectiveness of a parenting intervention, Families Preparing the New Generation (FPNG), and a youth curriculum, keepin' it REAL (kiR), on substance use prevention for middle school students in a large urban metro area of the southwest USA. The study aimed to generate usable knowledge on what works in adolescent substance use prevention and how it works best-a combined parent and youth programming or parent-only programming. A total of 532 adolescents in the 7th grade from 19 participating middle schools were randomly assigned into three intervention conditions: parent-youth (PY), parent-only (PO), and comparison (C). Read More

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December 2018

Sitagliptin vs. pioglitazone as add-on treatments in patients with uncontrolled type 2 diabetes on the maximal dose of metformin plus sulfonylurea.

J Endocrinol Invest 2018 Dec 10. Epub 2018 Dec 10.

Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran.

Aims: To compare the efficacy of sitagliptin versus pioglitazone as add-on drugs in patients with poorly controlled diabetes with metformin and sulfonylureas.

Methods: This is a randomized, open-label, parallel assignment clinical trial. Patients who had inadequate glycemic control [7% (53 mmol/mol) ≤ A1C < 11% (97 mmol/mol)] despite a minimum 6-month period of active treatment with metformin 2000 mg/day plus gliclazide 240 mg/day were enrolled in the study. Read More

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December 2018

Thirty days are inadequate for assessing readmission following complex hepatopancreatobiliary procedures.

Surg Endosc 2018 Dec 10. Epub 2018 Dec 10.

Division of Bariatric, Foregut and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook University Medical Center, 100 Nichols Road, HSC T18-040, Stony Brook, 11794, NY, USA.

Introduction: Early readmissions (30 days) have been used as a measure of health care quality. The purpose of our study was to evaluate patterns of readmission for a longer period (up to 2 years) following Hepatopancreatobiliary (HPB) surgery in the state of New York.

Methods: The State Planning and Research Cooperative System database was utilized to identify patients undergoing complex HPB procedures between 2010 and 2012. Read More

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December 2018
1 Read

Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally-detected receptor ligand mixtures.

Toxicol Sci 2018 Dec 10. Epub 2018 Dec 10.

U.S. Environmental Protection Agency, Toxicity Assessment Division, Research Triangle Park, NC, United States.

Many glucocorticoid receptor (GR) agonists have been detected in waste and surface waters domestically and around the world, but the way a mixture of these environmental compounds may elicit a total glucocorticoid activity response in water samples remains unknown. Therefore, we characterized 19 GR ligands using a CV1 cell line transcriptional activation assay applicable to water quality monitoring. Cells were treated with individual GR ligands, a fixed ratio mixture of full or partial agonists, or a non-equipotent mixture with full and partial agonists. Read More

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December 2018

Evaluating the Medial Longitudinal Arch of the Foot: Correlations, Reliability, and Accuracy in People With a Low Arch.

Phys Ther 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiotherapy, Faculty of Medicine, Espinardo Campus, University of Murcia, Murcia, Spain.

Background: The medial longitudinal arch of the foot is a variable structure, and a decrease in its height could affect several functions and increase the risk of injuries in the lower limbs. There are many different techniques for evaluating it.

Objective: The objective of this study was to evaluate the correlations of the Navicular Drop Test, several footprint parameters, and the Foot Posture Index-6 in people with a low medial longitudinal arch. Read More

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December 2018

[Risk factors for in-hospital mortality among adult patients infected with colistin-resistant carbapenemase producing Klebsiella pneumoniae: a retrospective cohort study].

Rev Chilena Infectol 2018 ;35(3):239-245

Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Argentina.

Background: The emergence of colistin resistant carbapenemase-producing Klebsiella represents a therapeutic challenge and a worldwide problem.

Aim: To estimate the in-hospital mortality and identify the associated risk factors among patients with colistin-resistant carbapenemase-producing Klebsiella pneumoniae (KPC) that present with a clinical infection.

Methods: We carried a retrospective cohort study, including adult patients infected with colistin-resistant KPC hospitalized at a tertiary teaching hospital in Buenos Aires, Argentina during the year 2016. Read More

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January 2018
1 Read

[Sudden death in epilepsy].

Rev Med Chil 2018 Aug;146(8):902-908

Liga Chilena contra la Epilepsia, Clínica Dávila, Clínica Universidad de los Andes, Santiago, Chile.

The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. Read More

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The acute abdomen in pregnancy and postpartum of a teenager woman. Case report.

Rom J Morphol Embryol 2018 ;59(3):939-943

Department of Pediatric Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of General Surgery, University of Medicine and Pharmacy of Craiova, Romania;

The acute abdomen with its many clinical aspects is not a condition that eludes pregnancy; acute appendicitis being the most frequently incriminated, but when it comes to its complication - peritonitis and the pregnant is a teenager, the cases cited in the literature are quite rare. We present the case of a 15-year-old teenager pregnant within 24 weeks admitted from the emergency department with the diagnosis of acute abdomen and operated for generalized peritonitis due to a perforated appendicitis. The microscopic analysis of the specimen indicated the presence of ulceration and extensive and deep and necrosis of the appendicle wall, the residual structures being dissected by a predominantly polymorphonuclear leukocytes inflammatory infiltrate associated with eosinophilic fibrinous deposits. Read More

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January 2018

Gliosarcoma with long progression free survival: A case report and literature review.

Surg Neurol Int 2018 5;9:227. Epub 2018 Nov 5.

Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran.

Background: Gliosarcoma (GS) is a primary rare malignant brain tumor that accounts 4% of all high-grade glial tumor of the brain.

Case Description: We present a 45-year-old female admitted to our center with progressive headache since 1 month ago concomitant with nausea and emesis and generalized weakness. Imaging revealed a large solid mass with well-defined margin and some cystic portions that enhanced brightly with contrast. Read More

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November 2018

Understanding depressive symptoms in nursing home residents: the role of frequency and enjoyability of different expanded everyday activities relevant to the nursing home setting.

Eur J Ageing 2018 Dec 8;15(4):339-348. Epub 2018 Feb 8.

3Department of Geriatric Research, Bethanien-Hospital/Geriatric Center at Heidelberg University, 69126 Heidelberg, Germany.

Depressive symptoms are highly prevalent in nursing home (NH) residents. We assume that enjoyability, besides frequency of activities, is an important facet of expanded everyday activities (EEAs; Baltes et al., in: Baltes and Mayer (eds) The Berlin aging study, University of California Press, Berkeley, 2001) and affects residents' depressive symptoms. Read More

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December 2018

A case of a patient with severe epidermolysis bullosa surviving to adulthood.

Int J Gen Med 2018 15;11:413-421. Epub 2018 Nov 15.

Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russia,

Purpose: The aim of this study was to evaluate the progression of a case of a patient with epidermolysis bullosa (EB) since early age who survived to adulthood, presenting with recurrent skin blisters and disfiguring scars and disabling musculoskeletal deformities.

Background: EB is a rare group of inherited diseases that affect the skin fragility causing it to blister in response to even minor trauma. Established novel treatments are limited in the literature due to its rarity, and more research is needed to set a global management approach. Read More

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November 2018

Prevalence of childhood and adolescence epilepsy in Upper Egypt (desert areas).

Egypt J Neurol Psychiatr Neurosurg 2018 9;54(1):34. Epub 2018 Nov 9.

2Department of Neurology, Minia University, Minya, Egypt.

Background: A high prevalence of epilepsy in children is frequently found in developing countries.

Objective: This study aimed to determine the prevalence and clinical pattern of childhood and adolescence epilepsy in Upper Egypt.

Methods: This is a door-to-door study conducted on all inhabitants < 18 years in Al Kharga district and Al Qusier city (36,195 subjects). Read More

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November 2018

CRC21: Full Mouth Rehabilitation in a Patient with Severe Generalized Tooth Wear as a result of Prolonged Plant-Based Diet.

J Indian Prosthodont Soc 2018 Oct;18(Suppl 1):S44

Deparment of Restorative Dentistry, Faculty of Dentistry, Uni of Malaya, Kuala Lumpur Malaysia.

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October 2018