1,384,552 results match your criteria General Pharmacology[Journal]


[The multifaceted concept of mental disorder].

Authors:
Heinz Häfner

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Zentralinstitut für Seelische Gesundheit, AG Schizophrenieforschung; Medizinische Fakultät Mannheim / Universität Heidelberg.

The concept of mental disorder has many facets. Specific concepts of disease or disorder stand for individual entities, classified as diagnoses. Ideally, they are based on discrete physical, neurobiological or - as is the case with hereditary diseases - genetic findings. Read More

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December 2018

Assessment of Exercise Capacity in Children with Type 1 Diabetes in the Cooper Running Test.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland.

Regular physical activity increases lifespan for those with type 1 diabetes. However, disease-related barriers may deter children from exercise and affect their fitness. This study examined the safety of the Cooper test concerning diabetes-related acute complications in children with type 1 diabetes and their fitness. Read More

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December 2018

Absence of strong skew scattering in crystals with multi-sheeted Fermi surfaces.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Institute of Physics, Martin-Luther-Universitat Halle-Wittenberg, Halle, Sachsen-Anhalt, GERMANY.

We consider an extrinsic contribution to the anomalous and spin Hall effect in dilute alloys based on Fe, Co, Ni, and Pt hosts with different substitutional impurities. It is shown that a strong skew-scattering mechanism is absent in such crystals with multi-sheeted Fermi surfaces. Based on this finding, we conclude on the mutual exclusion of strong intrinsic and skew-scattering contributions to the considered transport phenomena. Read More

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December 2018

Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats.

Aging (Albany NY) 2018 Dec 16. Epub 2018 Dec 16.

Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.

Many aging-associated physiological changes are known to occur in short- and long-lived species with different trajectories. Emerging evidence suggests that numerous life history trait differences between species are based on interspecies variations in gene expression. Little information is available, however, about differences in transcriptome changes during aging between mammals with diverging lifespans. Read More

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December 2018

Apatinib inhibits tumor growth and angiogenesis in PNET models.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

Z Wang, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. Read More

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December 2018

Adaptive behaviour and quality of life in school-age children with congenital visual disorders and different levels of visual impairment.

Res Dev Disabil 2018 Dec 14;85:154-162. Epub 2018 Dec 14.

Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London, UK; Neurodisability Service, Great Ormond Street Hospital for Children NHS Foundation Trust, UK.

Background: Adaptive behaviours are vital skills that allow individuals to function independently and are potentially amenable to behavioural interventions. Previous research indicated that adaptive behaviours are reduced in children and adolescents with severe to profound VI, but it was unclear if this was also the case for children with mild to moderate VI.

Aim: The aim of the study was to assess differences in adaptive behaviour in children with congenital visual disorders and different levels of visual impairment and their influence on quality of life and everyday strengths and difficulties. Read More

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December 2018

Current antifungal drugs and immunotherapeutic approaches as promising strategies to treatment of fungal diseases.

Biomed Pharmacother 2018 Dec 14;110:857-868. Epub 2018 Dec 14.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Invasive candidiasis (IC) can affect individuals with various underlying diseases hospitalized in different parts of hospitals. In recent decades, IC has caused 27-55% mortality in general population. Although Candida albicans (C. Read More

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December 2018

Prevalence of asthma in multiple sclerosis: A United States population-based study.

Mult Scler Relat Disord 2018 Dec 12;28:69-74. Epub 2018 Dec 12.

Neuroimmunological Disorders Gene-Environment Epidemiology Laboratory, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

Background: Multiple sclerosis (MS) and asthma are complex multifactorial diseases which adversely impact daily functioning. However, the prevalence of asthma in those with MS is not clear. The objective of this study is to characterize the prevalence of asthma in those with MS, with considerations for age, gender, and race. Read More

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December 2018

Brain activity in struggling readers before intervention relates to future reading gains.

Cortex 2018 Nov 16;111:286-302. Epub 2018 Nov 16.

Department of Psychology, The University of Texas at Austin, Austin, TX, USA; Biomedical Imaging Center, The University of Texas at Austin, Austin, TX, USA.

Neural markers for reading-related changes in response to intervention could inform intervention plans by serving as a potential index of the malleability of the reading network in struggling readers. Of particular interest is the role of brain activation outside the reading network, especially in executive control networks important for reading comprehension. However, it is unclear whether any intervention-related executive control changes in the brain are specific to reading tasks or reflect more domain general changes. Read More

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November 2018

Smoking cessation in the context of recovery from drug and alcohol problems: Prevalence, predictors, and cohort effects in a national U.S. sample.

Drug Alcohol Depend 2018 Dec 8;195:6-12. Epub 2018 Dec 8.

Recovery Research Institute, Massachusetts General Hospital and Harvard Medical School, 151 Merrimac Street, Boston, MA, 02114, USA.

Background: Tobacco and alcohol and other drug (AOD) use remain prominent risk factors for morbidity, mortality, and health care utilization. Moreover, these often cluster together within persons, exponentiating health risks. Little is known regarding if and when people resolving AOD problems stop smoking, who stops, and whether recent general population trends toward smoking cessation are evident also among persons more recently entering recovery. Read More

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December 2018

Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models.

Environ Int 2018 Dec 14;123:325-336. Epub 2018 Dec 14.

State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Background: The evaluation of the chemical impact on human health is usually constrained to the analysis of the health effects of exposure to a single chemical or a group of similar chemicals at one time. The effects of chemical mixtures are seldom analyzed. In this study, we applied three statistical models to assess the association between the exposure to a mixture of seven xenobiotics (three phthalate metabolites, two phenols, and two pesticides) and obesity. Read More

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December 2018

Chemical characterization and source apportionment of PM personal exposure of two cohorts living in urban and suburban Beijing.

Environ Pollut 2018 Dec 4;246:225-236. Epub 2018 Dec 4.

College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Regional Atmospheric Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address:

In the study, personal PM exposures and their source contributions were characterized for 159 subjects living in the Beijing Metropolitan area. The exposures and sources were examined as functions of residential location, season, vocation, cigarette smoking, and time spent outdoors. Sampling was performed for two categories of volunteers, guards and students, that lived in urban and suburban areas of Beijing. Read More

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December 2018

Self-compassion and depression, anxiety, and resilience in adults with epilepsy.

Epilepsy Behav 2018 Dec 14;90:154-161. Epub 2018 Dec 14.

Division of Health Research, Faculty of Health and Medicine, Furness College, Lancaster University, Lancaster LA1 4YG, UK. Electronic address:

Background: Research suggests that people with epilepsy (PWE) are more likely to experience depression and anxiety than the general population. Given the adversity associated with the condition, resilience may also be important. However, to date, resilience has been largely overlooked in the epilepsy literature. Read More

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December 2018

Discovering market segments for hunted wild game meat.

Meat Sci 2018 Nov 29;149:163-176. Epub 2018 Nov 29.

Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Via Celoria, 10, 20133 Milano, Italy. Electronic address:

Recent years have seen a notable increase in the popularity of hunted wild game meat (HWGM) among consumers. This has led to a growing number of emerging markets for HWGM in many developed countries, including Europe. However, expansion of these markets is often hampered by the lack of a professional supply chain. Read More

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November 2018

Impairment in complex activities of daily living is related to neurodegeneration in Alzheimer's disease-specific regions.

Neurobiol Aging 2018 Nov 26;75:109-116. Epub 2018 Nov 26.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Impairment in instrumental activities of daily living (IADL) is an early clinical feature of Alzheimer's disease (AD). The neurobiology underlying IADL disruptions is still unclear. We aimed to investigate the relationship between IADL functioning and cortical atrophy across the AD spectrum. Read More

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November 2018

Hemopatch as a new dural sealant: A clinical observation.

Clin Neurol Neurosurg 2018 Dec 11;176:133-137. Epub 2018 Dec 11.

Department of Neurosurgery, United States.

Objectives: We analyzed our results using Hemopatch as a new dural sealant after durotomy in cranial and spinal neurosurgical procedures.

Patients And Methods: In our prospective single center study, we analyzed all patients who received Hemopatch used as a dural sealant between October 2016 and May 2017. 34 patients received Hemopatch used as a dural sealant in the study period. Read More

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December 2018

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA. Electronic address:

Background & Aims: It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis. Read More

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December 2018

Maternal urinary benzophenones and infant birth size: Identifying critical windows of exposure.

Chemosphere 2018 Nov 28;219:655-661. Epub 2018 Nov 28.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Benzophenones (BPs) are widely used as ultraviolet absorbers and fragrance retention agents. Evidences from animal studies have suggested that exposure to BPs may affect fetal growth, but human data is limited and no study is concerning critical windows of BPs exposure throughout pregnancy in relation to fetal growth. We aimed to investigate the associations of prenatal exposure to BPs with birth size and examine the critical exposure windows of fetus development. Read More

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November 2018

Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.

Background: Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking.

Objective: The present post hoc analysis was aimed to investigate the practicality of the most relevant international classifications proposed by the European Academy of Allergology and Clinical Immunology (EAACI), the American Academy of Asthma, Allergology and Clinical Immunology /American College of Allergy, Asthma and Immunology (AAAACI/ACAAI), and the World Allergy Organization (WAO) using data provided by the longitudinal European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI) based on daily clinical practice in 3 countries in Europe.

Methods: One hundred and nine SAR over 4363 AIT courses were classified as mild (n=78, 71. Read More

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December 2018
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A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Institute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland. Electronic address:

No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of changes in mRNA, protein, and phosphopeptide expression levels from human temporal cortical samples, with varying degree of AD-related pathology. This approach highlighted fluctuation in synaptic and mitochondrial function as the earliest pathological events in brain samples with AD-related pathology. Read More

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December 2018

Hysteroscopic Resection of Endometrial Polyps and Assisted Reproductive Technology Pregnancy Outcomes Compared with No Treatment: A Systematic Review.

J Minim Invasive Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Endometrial polyps are frequently encountered in the uterine cavity of infertile women. There is much debate regarding the treatment of endometrial polyps in patients who are undergoing assisted reproductive technology (ART). A systematic review was performed by searching PubMed, Embase, and the Cochrane Library for retrospective or prospective studies that compared the effect of hysteroscopic resection of polyps with no treatment on pregnancy outcomes of patients who underwent ART. Read More

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December 2018

Diurnal Regulation of Sphingolipids in Blood.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 14. Epub 2018 Dec 14.

Department of General Pharmacology and Toxicology, Goethe University Hospital, Frankfurt am Main, Germany.

Key homeostatic functions are regulated in a diurnal manner and a miss-alignment of such rhythms is believed to contribute to the pathophysiology of several diseases. Signaling sphingolipids (SLs) in plasma such as sphingosine 1-phosphate control lymphocytic trafficking, vascular reactivity and platelet activity, physiological functions all of which display a diurnal rhythm themselves. However, the rhythmicity of SL metabolism in plasma and its potential causes have not been sufficiently investigated so far. Read More

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December 2018

Exhaled and nasal nitric oxide measurement in the evaluation of chronic cough.

Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.

Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Naples, Italy.

Chronic cough is one of the most common and troublesome nonspecific respiratory symptom for which patients seek a general practitioner and specialist advice. It is conventionally defined as a cough lasting for more than 8 weeks. Exhaled nitric oxide has proven to be a specific biomarker capable to discriminate between differential diagnoses of chronic cough and simultaneously provide information about the response to specific treatment. Read More

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December 2018

Body compassion safeguards against the impact of major life events on binge eating.

Appetite 2018 Dec 14. Epub 2018 Dec 14.

CINEICC - Center for Research in Neuropsychology and Cognitive Behavioral Intervention, Portugal. Electronic address:

Body compassion is a fresh construct that incorporates two multidimensional concepts: body image and self-compassion. Although self-compassion has revealed a protective role against body image and eating-related problems (e.g. Read More

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December 2018

Direct antimicrobial susceptibility tests of bacteria and yeasts from positive blood cultures by using serum separator gel tubes and MALDI-TOF MS.

J Microbiol Methods 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, China. Electronic address:

Early and appropriate antimicrobial treatment can effectively reduce the mortality rate caused by bloodstream infections (BSIs) and is critical for favorable patient outcomes. In general, >90% of positive blood cultures will show positive results within 48 h after incubation in the BACTECTM FX system. However, an additional 6-8 h are required to obtain clones of the bacterium and another 10-24 h to obtain antimicrobial susceptibility test (AST) results. Read More

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December 2018

Optic nerve head width and retinal nerve fiber layer changes are good indexes for validating the successful induction of experimental anterior ischemic optic neuropathy.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Eye Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Reproducible skills are essential for successful induction of a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by measuring the natural course of optic nerve head (ONH) width and retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. Read More

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December 2018

Long non-coding RNA Hotair promotes gastric cancer progression via miR-217-GPC5 axis.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China. Electronic address:

Aims: The oncogenic role of lncRNA Hotair has been acknowledged in subset of malignancies, including gastric cancer (GC). However, the detailed molecular mechanisms that contribute to its oncogenic role of are largely elusive. This study was designed to explore the underlying mechanism that contributes the regulatory role of Hotair in GC pathogenesis and progression. Read More

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December 2018

Fluvastatin-mediated down-regulation of SATB1 affects aggressive phenotypes of human non-small-cell lung cancer cell line H292.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Aims: Fluvastatin reduces tumor proliferation and increased apoptotic activity in various cancers. Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that reprogrammes the gene transcription profiles of tumors to promote growth and metastasis. The antitumor effect and molecular mechanisms of fluvastatin on lung cancer is poorly understood. Read More

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December 2018

The Optimal Treatment for Stage IIIA-N2 Non-small-cell Lung Cancer: A Network Meta-analysis.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China. Electronic address:

Background: The optimal treatment for stage IIIA-N2 non-small-cell lung cancer (NSCLC) is controversial. We aimed to address this important issue through a Bayesian network meta-analysis.

Methods: We performed a search of electronic databases for randomized controlled trials comparing the following treatments: surgery, radiotherapy, chemotherapy and their multiple combinations before March 25, 2018. Read More

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December 2018

TUSARC PROGNOSTIC: Prognostic value of high sensitivity troponin T assay in asymptomatic high cardiovascular risk patients.

Am J Med 2018 Dec 14. Epub 2018 Dec 14.

Clinical testing laboratory, Hospital Santos Reyes Aranda de Duero Burgos, Spain.

Objectives: Prognostic value of high-sensitivity cardiac troponin T assays (hs-cTnT) have been carried out on selected populations in different studies and in registries of low cardiovascular risk general population. The aim of this study is to determine the prognostic value of hs-cTnT in a Spanish asymptomatic very high cardiovascular risk population.

Method: From previously prospective cohort of TUSARC (troponina T UltraSensible en pacientes Asintomáticos de alto Riesgo Cardiovascular) registry, follow up was done in 602 patients (93,18%). Read More

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December 2018
4 Reads

Prosodic aspects of repetition in Swedish-speaking children with developmental language disorder.

Int J Speech Lang Pathol 2018 Dec 17:1-12. Epub 2018 Dec 17.

a Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

Purpose: To examine repetition of stress and tonal word accents in real words and non-words in Swedish-speaking children with developmental language disorder (DLD), and to investigate the relation of prosodic repetition to measures of language ability.

Method: A cross-sectional study was undertaken with 30 monolingual Swedish-speaking children with DLD, mean age 4;11 (years;months) and 29 age-matched controls, mean age 5;1, who repeated words and non-words with systematically varying prosody. Group differences for the repetition of prosodic features, and correlations between repetition and phonology, grammar, and vocabulary, were explored. Read More

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December 2018

Movement Disorders in Treatable Inborn Errors of Metabolism.

Mov Disord 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

There are several hundred single-gene disorders that we classify as inborn errors of metabolism. Inborn errors of metabolism are often rare and highly heterogeneous multisystem diseases with non-neurological and neurological manifestations, commonly with onset during childhood. Movement disorders are among the most common neurological problems in inborn errors of metabolism, but, in many cases, remain poorly defined. Read More

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December 2018

Guidelines Versus Guidelines.

Ann Intern Med 2018 Dec;169(12):896-897

American Diabetes Association, Arlington, Virginia (W.T.C.).

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December 2018

Use of C-reactive protein for the early prediction of anastomotic leak after esophagectomy: Systematic review and Bayesian meta-analysis.

PLoS One 2018 17;13(12):e0209272. Epub 2018 Dec 17.

Department of Biomedical Sciences for Health, Division of General Surgery, University of Milan, IRCCS Policlinico San Donato, Milan, Italy.

Background: Early suspicion, diagnosis, and timely treatment of anastomotic leak after esophagectomy is essential. Retrospective studies have investigated the role of C-reactive protein (CRP) as early marker of anastomotic leakage. The aim of this systematic review and meta-analysis was to evaluate the predictive value of CRP after esophageal resection. Read More

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December 2018

Stable isotope signatures and nutritional sources of some dominant species from the PACManus hydrothermal area and the Desmos caldera.

PLoS One 2018 17;13(12):e0208887. Epub 2018 Dec 17.

Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P. R. China.

Deep-sea hydrothermal vents in the western Pacific are increasingly explored for potential mineral extraction. The study of the composition of the food web plays an important guiding role in the ecological protection and restoration of potential mining areas. The general picture of the nutritional sources of species should be established to assess the potential impacts of future mining activities on the biological composition and food sources. Read More

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December 2018

Continuous neuromuscular blockade infusion for out-of-hospital cardiac arrest patients treated with targeted temperature management: A multicenter randomized controlled trial.

PLoS One 2018 17;13(12):e0209327. Epub 2018 Dec 17.

Department of Emergency Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.

Introduction: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM).

Methods: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM. Read More

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December 2018

Disclosure of HIV serostatus and condomless sex among men living with HIV/AIDS in Florida.

PLoS One 2018 17;13(12):e0207838. Epub 2018 Dec 17.

Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States of America.

Despite campaigns to increase safer sex practices, there are people living with HIV/AIDS (PLWH) who do not disclose their HIV status to sexual partners and engage in condomless sex. The purpose of this research was to: 1) describe factors associated with disclosure of HIV status to sexual partners; and 2) determine if disclosure and/or receipt of prevention counseling are independently associated with condomless sex. We used the Florida Medical Monitoring Project to analyze data from 376 HIV positive men with more than one sexual partner. Read More

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December 2018

Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.

PLoS One 2018 17;13(12):e0208846. Epub 2018 Dec 17.

Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America.

There is evidence from longitudinal studies that being light at birth and weaning is associated with subsequent rapid weight gain in infants. This is referred to as "centile crossing", which can lead to increased risk of lifetime obesity, glucose dysregulation and type 2 diabetes. Here, pregnant CD-1 mice were hemi-ovariectomized so that the entire litter was contained in one uterine horn to increase variability in fetal growth rate. Read More

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December 2018

Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.

PLoS One 2018 17;13(12):e0208042. Epub 2018 Dec 17.

Department of Medicine, University of California San Francisco/ San Francisco VA Medical Center, San Francisco, California, United States of America.

Background: Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study.

Methods And Results: We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. Read More

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December 2018

Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

PLoS One 2018 17;13(12):e0208516. Epub 2018 Dec 17.

Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) in Japanese, we named it as". Read More

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December 2018
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miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2.

PLoS Genet 2018 Dec 17;14(12):e1007790. Epub 2018 Dec 17.

Department of Radiation Oncology, North China University of Science and Technology Affiliated People's Hospital, Tangshan, China.

Accumulating evidence indicates that miRNAs can be promising diagnostic and/or prognostic markers for various cancers. In this study, we identified a novel miRNA, miR-3607-3p, and its targets in non-small cell lung cancer (NSCLC). The expression of miR-3607-3p was measured and its correlation with patient prognosis was determined. Read More

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December 2018

Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.

PLoS One 2018 17;13(12):e0209248. Epub 2018 Dec 17.

Department of Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan.

Nickel is a component of several alloy types that are widely used in our environment, including several dental alloy types that cause intraoral metal contact allergy. However, metal-specific immune responses in the oral mucosa have not been elucidated because a suitable animal model has not been established. In this study, we established a novel murine model of nickel-induced intraoral metal contact allergy and aimed to elucidate the immune response in terms of T-cell receptor repertoire and cytokine profiles in inflamed oral mucosa. Read More

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December 2018
2 Reads

HIV screening among patients seeking care at Xuanwu Hospital: A cross-sectional study in Beijing, China, 2011-2016.

PLoS One 2018 17;13(12):e0208008. Epub 2018 Dec 17.

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Objectives: One-third of people living with HIV in China are still unaware of their status, so we sought to better understand HIV testing in the general hospital setting in China.

Methods: A cross-sectional study was conducted using the electronic medical records of all patients who attended Xuanwu Hospital in Beijing, January 1, 2011 to December 31, 2016. HIV screening and detection rates and characteristics of patients diagnosed with HIV were assessed. Read More

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December 2018

Robustness of the reproductive number estimates in vector-borne disease systems.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006999. Epub 2018 Dec 17.

Centre for Mathematics and the Environment, University of Exeter, Penryn Campus, Penryn, UK.

Background: The required efforts, feasibility and predicted success of an intervention strategy against an infectious disease are partially determined by its basic reproduction number, R0. In its simplest form R0 can be understood as the product of the infectious period, the number of infectious contacts and the per-contact transmission probability, which in the case of vector-transmitted diseases necessarily extend to the vector stages. As vectors do not usually recover from infection, they remain infectious for life, which places high significance on the vector's life expectancy. Read More

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December 2018

Peer-assisted learning after onsite, low-dose, high-frequency training and practice on simulators to prevent and treat postpartum hemorrhage and neonatal asphyxia: A pragmatic trial in 12 districts in Uganda.

PLoS One 2018 17;13(12):e0207909. Epub 2018 Dec 17.

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

An urgent need exists to improve and maintain intrapartum skills of providers in sub-Saharan Africa. Peer-assisted learning may address this need, but few rigorous evaluations have been conducted in real-world settings. A pragmatic, cluster-randomized trial in 12 Ugandan districts provided facility-based, team training for prevention and management of postpartum hemorrhage and birth asphyxia at 125 facilities. Read More

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December 2018

The predictive value of Cardiodynamicsgram in myocardial perfusion abnormalities.

PLoS One 2018 17;13(12):e0208859. Epub 2018 Dec 17.

School of Automation Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.

Myocardial perfusion abnormalities are the first sign of the ischemic cascade in the development of coronary artery disease (CAD). Thus, the early detection of myocardial perfusion abnormalities is significant for the prevention of CAD. Recently, a novel noninvasive method named Cardiodynamicsgram (CDG) has been proposed for early detection of CAD. Read More

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December 2018
1 Read

The courses of maternal and paternal depressive and anxiety symptoms during the prenatal period in the FinnBrain Birth Cohort study.

PLoS One 2018 17;13(12):e0207856. Epub 2018 Dec 17.

University of Turku, Institute of Clinical Medicine, Turku Brain and Mind Center, FinnBrain Birth Cohort Study, Turku, Finland.

Maternal prenatal symptoms of depression and anxiety have been suggested to impose differential effects on later offspring development, depending on their characteristics, such as timing, intensity and persistence. Paternal symptoms have been less investigated. While knowledge on these trajectory characteristics is essential for improved comprehension of prenatal stress, prospective studies including both expecting parents have been scarce. Read More

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December 2018

Who self-medicates? Results from structural equation modeling in the Greater Paris area, France.

PLoS One 2018 17;13(12):e0208632. Epub 2018 Dec 17.

Department of Social Epidemiology, Institut Pierre Louis d'Epidémiologie et de Santé Publique (UMRS 1136), INSERM, Sorbonne Université, Paris, France.

Objectives: Our study aimed to describe the prevalence of self-medication among the Paris adult population and to identify the factors associated with self-medication.

Materials And Methods: This cross-sectional study was based on data collected from the SIRS cohort (a French acronym for "Health, inequalities and social ruptures") in 2005 in the Paris metropolitan area using a face-to-face administration questionnaire among a representative sample of 3,023 French-speaking adults. Structural equation models were used to investigate the factors associated with self-medication in the overall population and according to income. Read More

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December 2018

Quality circles for quality improvement in primary health care: Their origins, spread, effectiveness and lacunae- A scoping review.

PLoS One 2018 17;13(12):e0202616. Epub 2018 Dec 17.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Quality circles or peer review groups, and similar structured small groups of 6-12 health care professionals meet regularly across Europe to reflect on and improve their standard practice. There is debate over their effectiveness in primary health care, especially over their potential to change practitioners' behaviour. Despite their popularity, we could not identify broad surveys of the literature on quality circles in a primary care context. Read More

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December 2018

The sickle cell trait and end stage renal disease in Salvador, Brazil.

PLoS One 2018 17;13(12):e0209036. Epub 2018 Dec 17.

Instituto Gonçalo Moniz-FIOCRUZ-Bahia, Salvador, Brazil.

Background: Carriers of the sickle cell trait (HbAS) usually remain asymptomatic. However, under conditions of low tissue oxygenation, red blood cell sickling and vascular obstruction may develop. Chronic kidney disease (CKD) can arise from conditions promoting low-oxygen in kidney tissue, which may be aggravated by the presence of the sickle cell trait. Read More

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December 2018
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