1,177 results match your criteria Gene Expression Patterns [Journal]


Bmp signaling in molar cusp formation.

Gene Expr Patterns 2019 Apr 10. Epub 2019 Apr 10.

Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:

Tooth cusp is a crucial structure, since the shape of the molar tooth is determined by number, shape, and size of the cusp. Bone morphogenetic protein (Bmp) signaling is known to play a critical role in tooth development, including in initiation. However, it remains unclear whether Bmp signaling is also involved in cusp formation. Read More

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http://dx.doi.org/10.1016/j.gep.2019.04.002DOI Listing

Expression analysis of the aquaporins during zebrafish embryonic development.

Gene Expr Patterns 2019 Apr 2;32:38-43. Epub 2019 Apr 2.

School of Life Science, Co-innovation Center of Neuroregeneration, Key Laboratory of Neurogeneration of Jiangsu and MOE, Nantong University, Nantong, China. Electronic address:

The aquaporins are integral membrane proteins from a larger family of major intrinsic protein (MIP) that form pores in the membrane of cells. These proteins selectively transport water and other small uncharged solutes across cell plasma membranes. The organization of water within cells and tissues is fundamental to life, and the aquaporins play an important role in serving as the plumbing system for cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183020
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http://dx.doi.org/10.1016/j.gep.2019.04.001DOI Listing
April 2019
3 Reads

Identification of regulatory elements recapitulating early expression of L-plastin in the zebrafish enveloping layer and embryonic periderm.

Gene Expr Patterns 2019 Mar 30;32:53-66. Epub 2019 Mar 30.

Department of Biological Sciences, DePaul University, USA. Electronic address:

We have cloned and characterized an intronic fragment of zebrafish lymphocyte cytosolic protein 1 (lcp1, also called L-plastin) that drives expression to the zebrafish enveloping layer (EVL). L-plastin is a calcium-dependent actin-bundling protein belonging to the plastin/fimbrin family of proteins, and is necessary for the proper migration and attachment of several adult cell types, including leukocytes and osteoclasts. However, in zebrafish lcp1 is abundantly expressed much earlier, during differentiation of the EVL. Read More

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http://dx.doi.org/10.1016/j.gep.2019.03.001DOI Listing
March 2019
1 Read

Spatiotemporal expression pattern of Sjfz7 and its expression comparison with other frizzled family genes in developmental stages of Schistosoma japonicum.

Gene Expr Patterns 2019 Mar 6;32:44-52. Epub 2019 Mar 6.

Shanghai Veterinary Research Institute, CAAS, Shanghai, 200241, China. Electronic address:

Wnts are secreted signaling molecules that are implicated in a variety of growth-related processes. Frizzled proteins have been identified as receptors for Wnt ligands in vertebrates and invertebrates, but a functional role for dioecious flatworm Frizzleds has not been determined. To evaluate the endogenous role of Frizzled proteins during development, we have identified and characterized a Schistosoma japonicum frizzled gene (Sjfz7). Read More

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http://dx.doi.org/10.1016/j.gep.2019.02.005DOI Listing

Evolution of the Rho guanine nucleotide exchange factors Kalirin and Trio and their gene expression in Xenopus development.

Gene Expr Patterns 2019 Mar 4;32:18-27. Epub 2019 Mar 4.

Philipps-Universität Marburg, Faculty of Biology, Molecular Embryology, Marburg, Germany; DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps-Universität Marburg, Marburg, Germany. Electronic address:

Guanine nucleotide exchange factors (GEFs) activate Rho GTPases by accelerating their GDP/GTP exchange. Trio and its paralog Kalirin (Kalrn) are unique members of the Rho-GEFs that harbor three catalytic domains: two functional GEF domains and a serine/threonine kinase domain. The N-terminal GEF domain activates Rac1 and RhoG GTPases, while the C-terminal GEF domain acts specifically on RhoA. Read More

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http://dx.doi.org/10.1016/j.gep.2019.02.004DOI Listing
March 2019
2 Reads

GTP binding protein 10 is a member of the OBG family of proteins and is differentially expressed in the early Xenopus embryo.

Gene Expr Patterns 2019 Mar 1;32:12-17. Epub 2019 Mar 1.

Sciences Division, Brandywine Campus, The Pennsylvania State University, Media, PA, 19063, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183012
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http://dx.doi.org/10.1016/j.gep.2019.02.002DOI Listing
March 2019
5 Reads

Expression of the heparin-binding growth factors Midkine and pleiotrophin during ocular development.

Gene Expr Patterns 2019 Feb 27;32:28-37. Epub 2019 Feb 27.

Department of BioSciences, Rice University, Houston, TX, USA. Electronic address:

Midkine (MDK) and Pleiotrophin (PTN) belong to a group of heparin-binding growth factors that has been shown to have pleiotropic functions in various biological processes during development and disease. Development of the vertebrate eye is a multistep process that involves coordinated interactions between neuronal and non-neuronal cells, but very little is known about the potential function of MDK and PTN in these processes. In this study, we demonstrate by section in situ hybridization, the spatiotemporal expression of MDK and PTN during ocular development in chick and mouse. Read More

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http://dx.doi.org/10.1016/j.gep.2019.02.001DOI Listing
February 2019

An in situ hybridization study of MMP-2, -9, -13, -14, TIMP-1, and -2 mRNA in fetal mouse mandibular condylar cartilage as compared with limb bud cartilage.

Gene Expr Patterns 2019 Feb 27;32:1-11. Epub 2019 Feb 27.

Department of Maxillofacial Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

The main purpose of this in situ hybridization study was to investigate MMPs and TIMPs mRNA expression in developing mandibular condylar cartilage and limb bud cartilage. At E14.0, MMP-2, -14, TIMP-1 and -2 mRNAs were expressed in the periosteum of mandibular bone, and in the condylar anlage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183019
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http://dx.doi.org/10.1016/j.gep.2019.02.003DOI Listing
February 2019
3 Reads

Regionalized nervous system in Hydra and the mechanism of its development.

Gene Expr Patterns 2019 01 21;31:42-59. Epub 2019 Jan 21.

Department of Developmental Genetics, National Institute of Genetics, Yata 1,111, Mishima, Shizuoka, 411-8540, Japan; Department of Molecular Evolution and Genomics, Center for Organismic Studies, Heidelberg, University of Heidelberg, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany. Electronic address:

The last common ancestor of Bilateria and Cnidaria is considered to develop a nervous system over 500 million years ago. Despite the long course of evolution, many of the neuron-related genes, which are active in Bilateria, are also found in the cnidarian Hydra. Thus, Hydra is a good model to study the putative primitive nervous system in the last common ancestor that had the great potential to evolve to a more advanced one. Read More

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http://dx.doi.org/10.1016/j.gep.2019.01.003DOI Listing
January 2019
2 Reads

Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain.

Gene Expr Patterns 2019 01 8;31:32-41. Epub 2019 Jan 8.

Bio-Medical Center, College of Life Science & Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; Department of Molecular Genetics, The Ohio State University, Columbus, OH, 43210, USA; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, 43210, USA; Center for Muscle Health and Neuromuscular Disorders, The Ohio State University, Nationwide Children's Hospital, Columbus, OH, 43210, USA. Electronic address:

Rbfox RNA-binding proteins are expressed in the adult mammalian brain and are required for proper brain development and function. Studies in mice and humans have implicated Rbfox1/RBFOX1 in autism, neuronal excitation and epilepsy, and Rbfox2/RBFOX2 in cerebellar development. The zebrafish has emerged as a prominent model system for brain study, possessing neuroanatomical conservation with mammals and an extensive capacity for adult neurogenesis and plasticity. Read More

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http://dx.doi.org/10.1016/j.gep.2019.01.001DOI Listing
January 2019
2 Reads

Expression of teneurin-m/odd Oz during segmentation in the beetle Tribolium castaneum.

Gene Expr Patterns 2019 01 7;31:26-31. Epub 2019 Jan 7.

Division of Applied Life Science (BK21 Plus Program), Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju, 52828, South Korea; Division of Life Science, Gyeongsang National University, Jinju, 52828, South Korea. Electronic address:

The pair-rule gene teneurin-m/odd Oz (ten-m/odz) is required for the patterning of alternate segment boundaries in the early Drosophila embryo. Mutant phenotypes of ten-m/odz display a typical pair-rule phenotype in which odd-numbered segments are eliminated. Consistent with its pair-rule function, Ten-m/Odz protein is expressed in a seven-stripe pattern before the onset of gastrulation. Read More

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http://dx.doi.org/10.1016/j.gep.2019.01.002DOI Listing
January 2019
1 Read

Expressional and functional analyses of epididymal SPINKs in mice.

Gene Expr Patterns 2019 01 25;31:18-25. Epub 2018 Dec 25.

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. Electronic address:

Epididymal maturation is critical for acquisition of motility and fertilizing capacity by sperm. During epididymal transit, the surface of sperm undergoes prominent sequential changes through interactions with secreted proteins, including protease inhibitors. In the present study, we characterized three epididymis-specific SPINKs (serine protease inhibitors, Kazal-type): SPINK8, SPINK11, and SPINK12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183015
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http://dx.doi.org/10.1016/j.gep.2018.12.001DOI Listing
January 2019
25 Reads

Developmental expression patterns of protein kinase A catalytic subunits in zebrafish.

Gene Expr Patterns 2019 01 20;31:1-6. Epub 2018 Nov 20.

Department of Biology, University of Vermont, Burlington, VT, 05405, USA. Electronic address:

Protein kinase A (PKA), also known as cAMP dependent protein kinase, is an essential component of many signaling pathways, many of which regulate key developmental processes. Inactive PKA is a tetrameric holoenzyme, comprised of two catalytic (PRKAC), and two regulatory subunits. Upon cAMP binding, the catalytic subunits are released and thereby activated. Read More

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http://dx.doi.org/10.1016/j.gep.2018.11.001DOI Listing
January 2019
21 Reads

Analysis of Brassica napus dehydrins and their Co-Expression regulatory networks in relation to cold stress.

Gene Expr Patterns 2019 01 6;31:7-17. Epub 2018 Nov 6.

Department of Plant Biotechnology, Faculty of Agriculture, University of Guilan, Rasht, Iran.

Dehydrins (DHNs) are plant specific cold and drought stress-responsive proteins that belong to late embryogenesis abundant (LEA) protein families. B. napus DHNs (BnDHNs) were computationally analyzed to establish gene regulatory- and protein-protein interaction networks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183011
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http://dx.doi.org/10.1016/j.gep.2018.10.002DOI Listing
January 2019
9 Reads

A tissue-specific enhancer of the C. elegans nhr-67/tailless gene drives coordinated expression in uterine stem cells and the differentiated anchor cell.

Gene Expr Patterns 2018 12 4;30:71-81. Epub 2018 Nov 4.

Biology Department, Muhlenberg College, Allentown, PA, 18104, USA. Electronic address:

The nhr-67 nuclear receptor gene of Caenorhabditis elegans encodes the ortholog of the Drosophila tailless and vertebrate Tlx genes. In C. elegans, nhr-67 plays multiple roles in the development of the uterus during L2 and L3 larval stages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183011
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http://dx.doi.org/10.1016/j.gep.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373727PMC
December 2018
2 Reads

Expression of trpv channels during Xenopus laevis embryogenesis.

Gene Expr Patterns 2018 12 13;30:64-70. Epub 2018 Oct 13.

Department of Biology, Integrated Science Center, 540 Landrum Dr., College of William and Mary, Williamsburg, VA, 23185, USA. Electronic address:

Transient receptor potential (TRP) cation channel genes code for an extensive family of conserved proteins responsible for a variety of physiological processes, including sensory perception, ion homeostasis, and chemical signal transduction. The TRP superfamily consists of seven subgroups, one of which is the transient receptor potential vanilloid (trpv) channel family. While trpv channels are relatively well studied in adult vertebrate organisms given their role in functions such as nociception, thermoregulation, and osmotic regulation in mature tissues and organ systems, relatively little is known regarding their function during embryonic development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183010
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http://dx.doi.org/10.1016/j.gep.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319392PMC
December 2018
16 Reads

Class I histone deacetylases in retinal progenitors and differentiating ganglion cells.

Gene Expr Patterns 2018 12 1;30:37-48. Epub 2018 Sep 1.

Department of Biology, Indiana University-Purdue University Indianapolis, 723 W Michigan St, Indianapolis, IN, 46202, USA; Center for Developmental and Regenerative Biology, Indiana University- Purdue University Indianapolis, 723 W Michigan St, Indianapolis, IN, 46202, USA. Electronic address:

Background: The acetylation state of histones has been used as an indicator of the developmental state of progenitor and differentiating cells. The goal of this study was to determine the nuclear localization patterns of Class I histone deacetylases (HDACs) in retinal progenitor cells (RPCs) and retinal ganglion cells (RGCs), as the first step in understanding their potential importance in cell fate determination within the murine retina.

Results: The only HDAC to label RPC nuclei at E16 and P5 was HDAC1. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.007DOI Listing
December 2018
2 Reads

ALS-associated genes display CNS expression in the developing zebrafish.

Gene Expr Patterns 2018 12 27;30:14-31. Epub 2018 Aug 27.

Department of Genetics, Development and Cell Biology, 2437 Pammel Drive, 2114 Molecular Biology, Iowa State University, Ames, IA, 50011, USA. Electronic address:

Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle atrophy resulting from the deterioration of motor neurons in the central nervous system (CNS). Recent genome-wide association studies have revealed several genes linked to ALS, further demonstrating the complexity of the disease. The zebrafish (Danio rerio) is an attractive model organism to study the function of the rapidly expanding number of ALS-associated genes, in part, due to the development of genome editing techniques that have facilitated specific gene targeting. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.003DOI Listing
December 2018
4 Reads

Developmental expression of the slurp-like1/ly2.3/ly97.3 and slurp-like2/ly2.2/ly97.2 genes during zebrafish early embryogenesis.

Gene Expr Patterns 2018 12 24;30:32-36. Epub 2018 Aug 24.

Laboratory for Developmental Biology, Center for Medical Education and Sciences, Graduate School of Medical Science, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409-3898, Japan.

Mammalian SLURP1 and SLURP2 belong to the Ly-6/uPAR superfamily and are involved in maintaining the physiological integrity of keratinocytes. However, the developmental expression and functions of other Ly-6/uPAR family genes in vertebrates are still obscure. We have isolated novel Ly-6/uPAR family genes slurp-like1 (ly2. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.006DOI Listing
December 2018
3 Reads

Expression pattern of delta-like 1 homolog in developing sympathetic neurons and chromaffin cells.

Gene Expr Patterns 2018 12 23;30:49-54. Epub 2018 Aug 23.

Institute of Anatomy & Cell Biology, Albert-Ludwigs-University Freiburg, Albert-Str. 17, 79104, Freiburg, Germany; Department of Medicine, University of Fribourg, Route Albert-Gockel 1, 1700, Fribourg, Switzerland. Electronic address:

Delta-like 1 homolog (DLK1) is a member of the epidermal growth factor (EGF)-like family and an atypical notch ligand that is widely expressed during early mammalian development with putative functions in the regulation of cell differentiation and proliferation. During later stages of development, DLK1 is downregulated and becomes increasingly restricted to specific cell types, including several types of endocrine cells. DLK1 has been linked to various tumors and associated with tumor stem cell features. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.005DOI Listing
December 2018
3 Reads

Analysis of the FGFR spatiotemporal expression pattern within the chicken scleral ossicle system.

Gene Expr Patterns 2018 12 22;30:7-13. Epub 2018 Aug 22.

Dept. of Biology, Mount Saint Vincent University, Halifax, Canada. Electronic address:

Fibroblast Growth Factors (FGFs) play several important roles during organ morphogenesis and act as multi-functional growth factors that bind to their membrane bound receptors (FGFRs) and activate further downstream signalling pathways. Several studies have investigated the function and expression of FGF/FGFRs in endochondral bone development, however, we know little about their role in the development of neural crest derived intramembranous bones. Here, we investigate the expression of 'b' and c' isoforms of FGFRs 1-3 during the development of the scleral ossicles, a ring of neural crest derived intramembranous bones in the chicken eye. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.004DOI Listing
December 2018
3 Reads

Spatiotemporal expression of the cocaine- and amphetamine-regulated transcript-like (cart-like) gene during zebrafish embryogenesis.

Gene Expr Patterns 2018 12 17;30:1-6. Epub 2018 Aug 17.

Laboratory for Developmental Biology, Center for Medical Education and Sciences, Graduate School of Medical Science, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409-3989, Japan.

The cocaine- and amphetamine-regulated transcript (CART) genes are involved in the neural regulation of energy homeostasis; however, their developmental expressions and functions are not fully understood in vertebrates. We have identified a novel zebrafish cart-like gene that encodes a protein of 105 amino acids possessing sequence similarity to zebrafish and mammalian CART proteins. RT-PCR analysis revealed that the cart-like transcripts were maternally supplied and gradually decreased during the cleavage, blastula and gastrula stages; then, transcripts subsequently reaccumulated at the segmentation, pharyngula and hatching stages. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.002DOI Listing
December 2018
2 Reads

Molecular characterization of wdr68 gene in embryonic development of Xenopus laevis.

Gene Expr Patterns 2018 12 17;30:55-63. Epub 2018 Aug 17.

Instituto Superior de Investigaciones Biológicas (INSIBIO, CONICET-Universidad Nacional de Tucumán), Chacabuco 461, T4000ILI, San Miguel de Tucumán, Tucumán, Argentina; Instituto de Biología "Dr. Francisco D. Barbieri", Facultad de Bioquímica, Química y Farmacia de la Universidad Nacional de Tucumán, Chacabuco 461, T4000ILI, San Miguel de Tucumán, Tucumán, Argentina.

WDR68, also known as DCAF7, is a WD40 repeated domain protein highly conserved in eukaryotic organisms in both plants and animals. This protein participates in numerous cellular processes and exerts its function through interaction with other proteins. In the present work, we isolated, sequenced and characterized cDNA corresponding to the wdr68 gene in embryos of the amphibian Xenopus laevis. Read More

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http://dx.doi.org/10.1016/j.gep.2018.08.001DOI Listing
December 2018
3 Reads

The expression of natriuretic peptide receptors in developing zebrafish embryos.

Gene Expr Patterns 2018 09 7;29:65-71. Epub 2018 Jul 7.

Co-innovation Center of Neuroregeneration, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China. Electronic address:

There are three isoforms of natriuretic peptide (NP) specific cell surface receptor: NP receptor-A (NPRA), receptor-B (NPRB), and receptor-C (NPRC). They are also known as NPR1, NPR2 and NPR3, respectively. NPs and their receptors were revealed to involve in diverse cellular and physiological processes including renal, cardiovascular, neuronal, and immunological aspects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183005
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http://dx.doi.org/10.1016/j.gep.2018.07.001DOI Listing
September 2018
19 Reads

Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b.

Gene Expr Patterns 2018 09 17;29:82-87. Epub 2018 Jul 17.

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. Electronic address:

Members of the Arf-like (Arl) family of small GTP-binding proteins regulate a number of cellular functions and play important roles in cilia structure and signaling. The small GTPase Arl13a is a close paralog to Arl13b, a small GTPase required for normal cilia formation that causes Joubert Syndrome when mutated. As mutation of arl13b causes a slow retinal degeneration in zebrafish (Song et al. Read More

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http://dx.doi.org/10.1016/j.gep.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136450PMC
September 2018
2 Reads

ADAMTS9, a member of the ADAMTS family, in Xenopus development.

Gene Expr Patterns 2018 09 21;29:72-81. Epub 2018 Jun 21.

School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. Electronic address:

Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling. The human family includes 19 members. Read More

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http://dx.doi.org/10.1016/j.gep.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119763PMC
September 2018
2 Reads

Transcript profiling of salt tolerant tobacco mutants generated via mutation breeding.

Gene Expr Patterns 2018 09 21;29:59-64. Epub 2018 May 21.

Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, 34469, Istanbul, Turkey.

The main aim of the study is to identify the genes differentially, predominantly or specifically expressed in salt tolerant tobacco mutants, improved from Akhisar 97 and İzmir Özbaş varieties via mutation breeding, with respect to unstressed control plants. Seven tobacco mutants which have different salt tolerance capacities were evaluated by Gene Fishing analysis. Under stress conditions differentially expressed 100 reproducible bands were identified (74 of up-regulated and 20 of down-regulated while 6 were unknown). Read More

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http://dx.doi.org/10.1016/j.gep.2018.05.001DOI Listing
September 2018
2 Reads

Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers.

Gene Expr Patterns 2018 09 5;29:47-58. Epub 2018 May 5.

Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China; Department of Marine Biology, Ocean University of China, Qingdao, 266003, China. Electronic address:

Proteomic study has determined age-related changes in synthesis of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in muscle of post-menopausal women. However, little information is available regarding the expression and role of these proteins in early development and life span. In this study we showed that zebrafish ca2, myl2a, myl2b and selenbp1 were highly identical to their mammalian counterparts in primary and tertiary structures as well as genomic organization and syntenic map. Read More

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http://dx.doi.org/10.1016/j.gep.2018.04.007DOI Listing
September 2018
11 Reads

The spatial and developmental expression of mouse Vwa8 (von Willebrand domain-containing protein 8).

Gene Expr Patterns 2018 09 13;29:39-46. Epub 2018 Apr 13.

University of Illinois at Chicago, Department of Biological Sciences, 845 West Taylor St. M/C 066, Chicago, IL 60607-7060, United States.

The Drosophila gene c12.2 was isolated in a screen examining mRNA binding proteins. Drosophila c12. Read More

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http://dx.doi.org/10.1016/j.gep.2018.04.004DOI Listing
September 2018
6 Reads

Identification of runt family genes involved in planarian regeneration and tissue homeostasis.

Gene Expr Patterns 2018 09 9;29:24-31. Epub 2018 Apr 9.

College of Life Science, Henan Normal University, Xinxiang, 453007 Henan, China.

The runt family genes play important roles in physiological processes in eukaryotic organisms by regulation of protein transcription, such as hematopoietic system, proliferation of gastric epithelial cells and neural development. However, it remains unclear about the specific functions of these genes. In this study, the full-length cDNA sequences of two runt genes are first cloned from Dugesia japonica, and their roles are investigated by WISH and RNAi. Read More

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http://dx.doi.org/10.1016/j.gep.2018.04.006DOI Listing
September 2018
3 Reads

Enriched expression of the ciliopathy gene Ick in cell proliferating regions of adult mice.

Gene Expr Patterns 2018 09 7;29:18-23. Epub 2018 Apr 7.

Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address:

Cilia are essential for sensory and motile functions across species. In humans, ciliary dysfunction causes "ciliopathies", which show severe developmental abnormalities in various tissues. Several missense mutations in intestinal cell kinase (ICK) gene lead to endocrine-cerebro-osteodysplasia syndrome or short rib-polydactyly syndrome, lethal recessive developmental ciliopathies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X183001
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http://dx.doi.org/10.1016/j.gep.2018.04.005DOI Listing
September 2018
7 Reads

The expression of fgfr3 in the zebrafish head.

Gene Expr Patterns 2018 09 6;29:32-38. Epub 2018 Apr 6.

Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Plastic and Reconstructive Surgery, Stanley Manne Children's Research Institute, Chicago, IL, USA. Electronic address:

Fibroblast growth factor (FGF) signaling is essential for many developmental processes and plays a pivotal role in skeletal homeostasis, regeneration and wound healing. FGF signals through one of five tyrosine kinase receptors: Fgfr1a, -1b, -2, -3, -4. To characterize the expression of zebrafish fgfr3 from the larval stage to adulthood, we used RNAscope in situ hybridization on paraffin sections of the zebrafish head. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X173021
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http://dx.doi.org/10.1016/j.gep.2018.04.002DOI Listing
September 2018
12 Reads

Expression patterns of Yes-associated protein 1 in the developing mouse liver.

Gene Expr Patterns 2018 09 5;29:10-17. Epub 2018 Apr 5.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada; Cell and Developmental Biology Program, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada; Department of Medical Genetics and the School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada. Electronic address:

The Hippo signaling pathway regulates many cellular processes, but has been specifically associated with control organ size and tumor growth. Yes-associated protein 1 (YAP1) is a transcriptional cofactor, in the Hippo pathway, that regulates gene expression when localized in the nucleus. Elevated expression of YAP1 in adult mouse liver leads to hepatomegaly and can cause hepatocellular carcinoma; while the loss of function studies reveal its importance in regulating cholangiocyte development. Read More

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http://dx.doi.org/10.1016/j.gep.2018.04.003DOI Listing
September 2018
6 Reads

Epigenetic modifications in the embryonic and induced pluripotent stem cells.

Gene Expr Patterns 2018 09 4;29:1-9. Epub 2018 Apr 4.

Department of Biology, School of Sciences, Razi University, Kermanshah 67149-67346, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Epigenetic modifications are involved in global reprogramming of the cell transcriptome. Therefore, synchronized major shifts in the expression of many genes could be achieved through epigenetic changes. The regulation of gene expression could be implemented by different epigenetic events including histone modifications, DNA methylation and chromatin remodelling. Read More

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http://dx.doi.org/10.1016/j.gep.2018.04.001DOI Listing
September 2018
4 Reads

Age-dependent expression pattern in the mammalian brain of a novel, small peptide encoded in the 22q11.2 deletion syndrome region.

Gene Expr Patterns 2018 06 20;28:95-103. Epub 2018 Mar 20.

Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, United States. Electronic address:

22q11.2 deletion syndrome (22q11.2DS) carries increased risk for both physical and psychiatric symptoms, including a high risk for schizophrenia. Read More

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http://dx.doi.org/10.1016/j.gep.2018.03.004DOI Listing
June 2018
7 Reads

Astacin gene family of metalloproteinases in planarians: Structural organization and tissue distribution.

Gene Expr Patterns 2018 06 13;28:77-86. Epub 2018 Mar 13.

Department of Clinical and Experimental Medicine, University of Pisa, Via Volta 4, 56126 Pisa, Italy. Electronic address:

Planarian flatworms possess extraordinary regenerative capability and body plasticity, which rely on a composite population of stem cells, the neoblasts. Despite impressive advances have been recently achieved in the knowledge of neoblast biology, few is still known about factors that are released by differentiated tissues and influence the neoblast fate. Extracellular matrix (ECM) is a fundamental component of the stem cell niche and its remodeling affects stem cell fate. Read More

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http://dx.doi.org/10.1016/j.gep.2018.03.003DOI Listing
June 2018
6 Reads

Tracheal expression of Osiris gene family in Drosophila.

Gene Expr Patterns 2018 06 14;28:87-94. Epub 2018 Mar 14.

Department of Biological Sciences, Oakland University, USA. Electronic address:

The Drosophila trachea is a premier genetic system to investigate the fundamental mechanisms of tubular organ formation. Development of the trachea consists of the well understood early branch specification and migration processes, and the less clear later branch maturation process including the apical membrane expansion, cytoskeleton rearrangement, luminal matrix clearance, and air-filling. We identified seven members of the Osiris (Osi) gene family with obvious tracheal expression in Drosophila. Read More

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http://dx.doi.org/10.1016/j.gep.2018.03.001DOI Listing
June 2018
3 Reads

Investigation of LAMTOR1 gene and protein expressions in germinal vesicle and metaphase II oocytes and embryos from 1-cell to blastocyst stage in a mouse model.

Gene Expr Patterns 2018 06 3;28:72-76. Epub 2018 Mar 3.

Department of Obstetrics and Gynecology, Cumhuriyet University Faculty of Medicine, 58140, Sivas, Turkey.

Improving the success of in vitro fertilization (IVF) and infertility treatment depend on understanding basic cellular and molecular mechanisms of human preimplantation development. Pre-implantation mouse embryo model is an ideal empiric system to understand these mechanisms. This study was aimed to investigate the gene and protein expressions of LAMTOR1 in mouse oocytes and pre-implantation embryos at different developmental stages. Read More

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http://dx.doi.org/10.1016/j.gep.2018.03.002DOI Listing
June 2018
8 Reads

Distribution of gonadotropin-inhibitory hormone (GnIH) in male Luchuan piglets.

Gene Expr Patterns 2018 06 24;28:42-53. Epub 2018 Feb 24.

College of Animal Science and Technology, Guangxi University, Nanning, Guangxi, 530004, PR China. Electronic address:

Gonadotropin inhibitory hormone (GnIH) has emerged as a novel hypothalamic neuropeptide that actively inhibits gonadotropin release in birds and mammals. Recent evidence indicates that GnIH not only acts as a key neurohormone that controls vertebrate reproduction but is also involved in stress response, food intake, and aggressive and sexual behaviors, suggesting a broad physiological role for this neuropeptide. To elucidate its multiple sites of action and potential functions, studying the detailed distribution of GnIH in different organs, except for the hypothalamus-pituitary-ovary/testis axis, is necessary. Read More

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http://dx.doi.org/10.1016/j.gep.2018.02.004DOI Listing
June 2018
3 Reads

Molecular characterization, tissue distribution, localization and mRNA expression of the bucky ball gene in the Dabry's sturgeon (Acipenser dabryanus) during oogenesis.

Gene Expr Patterns 2018 06 23;28:62-71. Epub 2018 Feb 23.

Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture of China, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China; Freshwater Fisheries Research Center, Chinese Academy of Fisheries Science, Wuxi 214081, China. Electronic address:

In many organisms, germ cells are specified during embryogenesis by the inheritance of maternally deposited RNAs and proteins termed germ plasm. In vertebrates, the bucky ball (buc) gene plays an essential role in the germ plasm aggregation. In this study, the full-length cDNA of buc homologue in Dabry's sturgeon, Adbuc, was isolated and characterized. Read More

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http://dx.doi.org/10.1016/j.gep.2018.02.003DOI Listing
June 2018
13 Reads

Expression of the adhesion G protein-coupled receptor A2 (adgra2) during Xenopus laevis development.

Gene Expr Patterns 2018 06 17;28:54-61. Epub 2018 Feb 17.

Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address:

The adhesion G protein-coupled receptor A2 (Adgra2) is a seven transmembrane receptor that has been described to be a regulator for angiogenesis in mice. Furthermore, the zebrafish ouchless mutant is unable to develop dorsal root ganglia through a disrupted trafficking of Adgra2. Besides RNA sequencing data, nothing is reported about Adgra2 in the south African crawled frog Xenopus laevis. Read More

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http://dx.doi.org/10.1016/j.gep.2018.02.002DOI Listing
June 2018
3 Reads

The expression patterns of vestigial like family member 4 genes in zebrafish embryogenesis.

Gene Expr Patterns 2018 06 14;28:34-41. Epub 2018 Feb 14.

CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Transcriptional cofactor Vestigial-like 4 (VGLL4) was considered to take part in the early stage of development. Different from human, three paralogs of vgll4 were found in zebrafish, which were vgll4a, vgll4b and vgll4l. However, the expression patterns of the three paralogs during zebrafish development remains unknown. Read More

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http://dx.doi.org/10.1016/j.gep.2018.02.001DOI Listing
June 2018
3 Reads

Screen for Slit/Robo signaling in trunk neural cells reveals new players.

Gene Expr Patterns 2018 06 7;28:22-33. Epub 2018 Feb 7.

California State University Northridge, Biology Dept., MC 8303, 18111 Nordhoff Street, Northridge, CA, 91330, United States. Electronic address:

Slits ligands and their Robo receptors are involved in quite disparate cell signaling pathways that include axon guidance, cell proliferation, cell motility and angiogenesis. Neural crest cells emerge by delamination from neural cells in the dorsal neural tube, and give rise to various components of the peripheral nervous system in vertebrates. It is well established that these cells change from a non-migratory to a highly migratory state allowing them to reach distant regions before they differentiate. Read More

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http://dx.doi.org/10.1016/j.gep.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980643PMC
June 2018
4 Reads

Early development of the enteric nervous system visualized by using a new transgenic zebrafish line harboring a regulatory region for choline acetyltransferase a (chata) gene.

Gene Expr Patterns 2018 06 2;28:12-21. Epub 2018 Feb 2.

University of Hyogo, Koto 3-2-1, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan. Electronic address:

The enteric nervous system (ENS) is the largest part of the peripheral nervous system in vertebrates. Toward the visualization of the development of the vertebrate ENS, we report our creation of a new transgenic line, Tg(chata:GGFF2) which has a 1.5-kb upstream region of the zebrafish choline acetyltransferase a (chata) gene followed by modified green fluorescent protein (gfp). Read More

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http://dx.doi.org/10.1016/j.gep.2018.01.003DOI Listing
June 2018
34 Reads

Oxygen-induced alterations in the expression of chromatin modifying enzymes and the transcriptional regulation of imprinted genes.

Gene Expr Patterns 2018 06 12;28:1-11. Epub 2018 Jan 12.

Department of Veterinary Physiology & Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843-4466, USA.

Embryo culture and assisted reproductive technologies have been associated with a disproportionately high number of epigenetic abnormalities in the resulting offspring. However, the mechanisms by which these techniques influence the epigenome remain poorly defined. In this study, we evaluated the capacity of oxygen concentration to influence the transcriptional control of a selection of key enzymes regulating chromatin structure. Read More

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http://dx.doi.org/10.1016/j.gep.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094953PMC
June 2018
8 Reads

Cloning and gene expression analysis of two cDNA of cysteine proteinase genes involved in programmed cell death in the inner integument from developing seeds of Jatropha curcas L.

Gene Expr Patterns 2018 01 19;27:122-127. Epub 2017 Dec 19.

Department of Clinical Dentistry, Federal University of Ceará (Brazil), Rua Monsenhor Furtado, 1178, Rodolfo Teófilo, 60430-355 Fortaleza, Ceará, Brazil.

In this paper, two cysteine proteinases were cloned from Jatropha curcas seeds. The full length cDNAs obtained from cloning of Jc-CysEP1 and Jc-CysEP2 genes were 1.516bp and 1500 pb, respectively. Read More

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http://dx.doi.org/10.1016/j.gep.2017.12.002DOI Listing
January 2018
5 Reads

Tissue specific expression and in-silico characterization of a putative cysteine synthase gene from Lathyrus sativus L.

Gene Expr Patterns 2018 01 13;27:128-134. Epub 2017 Dec 13.

Department of Microbiology, Vidyasagar University, Midnapore 721102, West Bengal, India. Electronic address:

Grass pea (Lathyrus sativus L.) is a worldwide popular pulse crop especially for its protein rich seeds with least production cost. However, the use of the crop became controversial due to the presence of non-protein amino acid, β-N-oxalyl-L-α, β-diaminopropionic acid (β-ODAP) in its seed and leaf, which is known as the principle neurotoxin to cause neurolathyrism (a motor neurodegenerative disease of humans and animals) during prolonged consumption as regular diet. Read More

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http://dx.doi.org/10.1016/j.gep.2017.12.001DOI Listing
January 2018
8 Reads

The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.

Gene Expr Patterns 2018 01 7;27:114-121. Epub 2017 Dec 7.

Department of Cell Biology & Human Anatomy, University of California, Davis School of Medicine, One Shields Avenue, Davis, CA 95616, United States. Electronic address:

The Atoh7 transcription factor catalyzes the rate-limiting step in the specification of retinal ganglion cells (RGCs). As a tool to study vertebrate retinal development, we validate an antibody that recognizes human and mouse Atoh7 polypeptide, using informative knockout and transgenic mouse tissues and overexpression experiments. The transient features of Atoh7 protein expression during retinal neurogenesis match the expected pattern at the tissue and cellular level. Read More

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http://dx.doi.org/10.1016/j.gep.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835195PMC
January 2018
10 Reads

Comparative expression analyses of bone morphogenetic protein 4 (BMP4) expressions in muscles of tilapia and common carp indicate that BMP4 plays a role in the intermuscular bone distribution in a dose-dependent manner.

Gene Expr Patterns 2018 01 26;27:106-113. Epub 2017 Nov 26.

Key Laboratory of Genetic Breeding and Aquaculture Biology of Freshwater Fishes, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, PR China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, PR China. Electronic address:

Intermuscular bones in fish negatively influence both meet processing and attractiveness to consumers. Tilapia (Oreochromis niloticus) and common carp (Cyprinus carpio) are both major farmed fish species globally, but whereas the former does not possess intermuscular bones, the latter does. Therefore, these two species might present a good model to study the genetic control of distribution of intermuscular bones in fish. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1567133X173010
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http://dx.doi.org/10.1016/j.gep.2017.11.005DOI Listing
January 2018
12 Reads

Hey1 and Hey2 are differently expressed during mouse tooth development.

Gene Expr Patterns 2018 01 16;27:99-105. Epub 2017 Nov 16.

Division of Anatomy, Department of Health Improvement, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan.

The Hey family (also known as Chf, Herp, Hesr, and Hrt) is a set of Hairy/Enhancer of Split-related basic helix-loop-helix type transcription factors. Hey1, Hey2, and HeyL have been identified in mammals. Although Hey proteins are known to regulate cardiovascular development, muscle homeostasis, osteogenesis, neurogenesis, and oncogenesis, their roles in tooth development have been largely obscure. Read More

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http://dx.doi.org/10.1016/j.gep.2017.11.004DOI Listing
January 2018
4 Reads