21,280 results match your criteria Gene[Journal]


Effects of Moringa oleifera Lam Extract (MOLE) in the heat shock protein 70 expression and germ cell apoptosis on experimentally induced cryptorchid testes of rats.

Gene 2018 Dec 6. Epub 2018 Dec 6.

Institut de recherches cliniques de Montreal (IRCM), Montreal, QC, Canada; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.

Moringa oleifera (Moringaceae) is a plant known for having high antioxidant potency, anticancer, hepatoprotective, cardioprotective etc. and many more activities. Besides these, Moringaceae has the potential for attenuating the male sexual dysfunction. Read More

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December 2018

Transcriptomic analysis of MicroRNA expression in enamel-producing cells.

Gene 2018 Dec 5. Epub 2018 Dec 5.

Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway; Department of Maxillofacial Surgery, Oslo University Hospital, Oslo, Norway.

There is little evidence for the involvement of microRNAs (miRNAs) in the regulation of circadian rhythms during enamel development. Few studies have used ameloblast-like cell line LS8 to study the circadian rhythm of gene activities related to enamel formation. However, the transcriptomic analysis of miRNA expression in LS8 cells has not been established yet. Read More

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December 2018

Toxic function of CD28 involving in the TLR/MyD88 signal pathway in the river pufferfish (Takifugu obscurus) after exposed to tributyltin chloride (TBT-Cl).

Gene 2018 Dec 5. Epub 2018 Dec 5.

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu 214081, China. Electronic address:

Cluster of differentiation 28 (CD28) is a co-stimulatory receptor found on the surface of T cells. Takifugu obscurus is a kind of anadromous fish species. In this study, the full-length sequence of To-CD28 was obtained, including a 672-bp open reading frame that encodes a peptide chain of 223 amino acids. Read More

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December 2018

Genetic polymorphisms in complement receptor 1 gene and its association with HBV-related liver disease: A case-control study.

Gene 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address:

Background: Several investigators have reported that complement receptor 1 (CR1) likely play a role in the pathogenesis of tumors, autoimmune and inflammatory diseases. However, the association of genetic polymorphisms of CR1 with risk of hepatitis B virus (HBV)-related liver disease remains unexplored.

Methods: In a case-control study of 399 HBV-related liver disease patients and 227 healthy controls, we genotyped two SNPs in CR1 (rs3811381 and rs2274567) and assessed their associations with risk of HBV-related liver disease. Read More

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December 2018

Association between adiponectin T94G polymorphism and resistant hypertension in young-onset Taiwanese patients.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan; Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Young-onset hypertensives (YOHs) with resistant hypertension (RH) have a greater long-term cardiovascular risk. The present study examined whether a functional adiponectin T94G polymorphism (rs2241766) is associated with RH in YOHs. We analyzed data from the Academia Sinica Collaborative Study on Hypertension Genetics in Taiwanese subjects to compare rs2241766 between YOHs with and without RH (≤50 years of age). Read More

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December 2018

Interaction between MTHFR 677C>T, PON1 192Q>R and PON1 55L>M polymorphisms and its effect on non-recurrent spontaneous abortion in Mexican women.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental-Alejandro Otero, Granada, Spain.

MTHFR is a key enzyme in folate metabolism. Some genetic polymorphisms code for a less efficient enzyme, increasing serum concentrations of homocysteine. This has been associated with inadequate feto-maternal circulation and increased risk of spontaneous abortion. Read More

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December 2018

Embryonic morphology observation and HOXC8 gene expression in crest cushions of Chinese Crested duck.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, Jiangsu, China. Electronic address:

The Chinese Crested duck (Fengtou duck) reappeared in China recently. Along with white feathers and a black bill and feet, the Fengtou duck has a high feather crest. This breed can be used for ornamental purposes or as a model organism; however, little is known about the genetic basis and development of its distinct morphological features. Read More

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December 2018

Integrated miRNA and mRNA transcriptomes of spleen profiles between Yorkshire and Queshan black pigs.

Gene 2018 Dec 7. Epub 2018 Dec 7.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002), China. Electronic address:

Disease causes large economic losses to the pig industry worldwidely, immunity plays an important role in the process of resistance to disease. In the present study, to elucidate the molecular mechanisms underlying different levels of disease resistance, we obtained the miRNA and mRNA expression profiles from the spleens of three groups of sows, including 180-day-old Queshan Black (Q-F), 3-day-old Yorkshire (Y-N) and 180-day-old Yorkshire (Y-F) pigs. The results showed that 85 miRNAs and 5093 genes were differentially expressed in Y-F vs Y-N, and 20 miRNAs and 1283 genes were differentially expressed in Q-F vs Y-F. Read More

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December 2018

Association of ATP binding cassette transporter 1 (ABCA 1) gene polymorphism with type 2 diabetes mellitus (T2DM) in Bangladeshi population.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address:

Aims: ATP-binding cassette transporter A1 (ABCA1) gene polymorphism has been reported as one of the genetic risk factors for T2DM in various populations with conflicting results. The aim of this study is to investigate the association of ABCA1 C69T polymorphism and lipid profile with T2DM in Bangladeshi population.

Materials And Methods: A total of 102 T2DM subjects and 98 healthy controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the PCR-RFLP technique. Read More

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December 2018

Expression of mammalian ASH1 and ASH4 in Drosophila reveals opposing functional roles in neurogenesis.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address:

To investigate whether the members of the mammalian Achaete-Scute Complex homologue (ASH) gene family have evolved functional differences, we used the patterning of bristles as a phenotypic marker. Drosophila uses a single genetic locus - the Achaete-Scute Complex - to demarcate the regions of the body where bristles can form. We found 4-5 Achaete-Scute Complex homologue genes (ASH) in the mammalian genome, which are homologous with scute in Drosophila. Read More

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December 2018

Donor one‑carbon metabolism gene single nucleotide polymorphisms predict the susceptibility of cancer recurrence after liver transplantation.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. Electronic address:

Background: Many enzymes involved in one‑carbon metabolism (OCM) are considered to have important roles in carcinogenesis, especially in hepatocellular carcinoma (HCC). However, the influence of polymorphisms in OCM genes on recurrence in HCC patients with liver transplantation has yet not been reported. The aim of this study was to explore the impact of donor liver graft OCM gene polymorphism on the prognosis of liver transplant recipients with HCC. Read More

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December 2018

Overexpression of RcLEC1-B, a HAP3 transcription factor of PLB from Rosa canina, increases the level of endogenous gibberellin and alters the development of cuticle and floral organs in Arabidopsis.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Department of Ornamental Horticulture and Landscape Architecture, China Agricultural University, Beijing 10093, China. Electronic address:

The HAP3 subfamily gene RcLEC1-B, was isolated from protocorm-like body (PLB) of Rosa canina, encodes 213 amino acid residues. It was shown that RcLEC1-B was specifically expressed in PLB of R. canina and its subcellular localization is in the nucleus. Read More

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December 2018
2.138 Impact Factor

Changes of alternative splicing in Arabidopsis thaliana grown under different CO concentrations.

Gene 2018 Dec 4. Epub 2018 Dec 4.

College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, PR China; Zhejiang-Malaysia Joint Research Center for Traditional Medicine, Zhejiang University, Hangzhou 310027, PR China. Electronic address:

Atmospheric CO level is one of the most important factors which affect plant growth and crop production. Although many crucial genes and pathways have been identified in response to atmospheric CO changes, the integrated and precise mechanisms of plant CO response are not well understood. Alternative splicing (AS) is an important gene regulation process that affects many biological processes in plants. Read More

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December 2018

Distinguishing CPT gene family members and vetting the sequence structure of a putative rubber synthesizing variant in Hevea brasiliensis.

Gene 2018 Dec 4. Epub 2018 Dec 4.

Genome Analysis Laboratory, Rubber Research Institute of India, Rubber Board P O, Kottayam, Kerala PIN-686009, India.

cis-Prenyltransferases (cis-PTs) constitute a large family of enzymes conserved during evolution and present in all domains of life. cis-PTs catalyze the cis-1,4-polymerization of isoprene units to generate isoprenoids with carbon skeletons varying from C10 (neryl pyrophosphate) to C > 10,000 (natural rubber). Though the previously reported CPTs in Hevea are designated based on sequence variations, their classification was done mostly by phylogenetic analysis using a mixture of partial as well as full length sequences often excluding the UTRs. Read More

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December 2018

Analysis of differential gene expression by RNA-seq data in ABCG1 knockout mice.

Gene 2018 Dec 4. Epub 2018 Dec 4.

Allwegene Technology Inc., Beijing 102209, PR China.

Aims: The previous studies on ABCG1 using genetically modified mice showed inconsistent results on atherosclerosis. The aim of this study was to determine whether accurate target knockout of ABCG1 would result in transcriptional changes of other atherosclerosis-related genes.

Methods: ABCG1 knockout mouse model was obtained by precise gene targeting without affecting non-target DNA sequences in C57BL/6 background. Read More

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December 2018
1 Read

Whole sequence of the mitochondrial DNA genome of Kearns Sayre Syndrome patients: Identification of deletions and variants.

Gene 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurology and Paediatrics, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.

Mitochondria both produce the energy of the cell as ATP via respiration and regulate cellular metabolism. Accordingly, any deletion or mutation in the mitochondrial DNA (mtDNA) may result in a disease. One of these diseases is Kearns Sayre syndrome (KSS), described for the first time in 1958, where different large-scale deletions of different sizes and at different positions have been reported in the mitochondrial genome of patients with similar clinical symptoms. Read More

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December 2018

Identification and molecular analysis of a lncRNA-HOTAIR transcript from secondary hair follicle of cashmere goat reveal integrated regulatory network with the expression regulated potentially by its promoter methylation.

Gene 2018 Dec 3. Epub 2018 Dec 3.

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address:

The HOTAIR transcript is transcribed from the antisense strand within the HOXC gene cluster, and it is thought to play a role in regulating the inductive capacity of dermal papilla cells during the reconstruction of hair-follicle. In the current investigation, we firstly isolated and characterized a lncRNA-HOTAIR transcript from the secondary hair follicle of cashmere goat. Also, we analyzed its transcriptional pattern and methylation level of HOTAIR gene promoter in secondary hair follicle of cashmere goat during anagen and telogen stages. Read More

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December 2018
1 Read
2.138 Impact Factor

Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No 1. Dr. "Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Gabriel Mancera No. 222, Colonia Del Valle, CP 03100 Ciudad de México, Mexico.

Objective: The renin-angiotensin system (RAS) is a hormonal signaling mechanism implicated in the atherosclerosis and regulation of blood pressure. Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke. The aim of this study was to examine the possible contribution of the I/D in the ACE gene, M235T and T174M in the angiotensinogen (AGT) gene polymorphisms with ischemic stroke in young Mexican population. Read More

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December 2018
1 Read

HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Department of Traumatic Orthopedics, The Second Hospital Affiliated to Lanzhou University, Lanzhou City, Gansu Province 730000, China.

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Aberrant expression of HOXA5 results in various diseases, including cancers. However, the specific function and molecular mechanism of HOXA5 in osteosarcoma is not fully understood. Read More

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December 2018
1 Read

Zinc finger antisense 1: A long noncoding RNA with complex roles in human cancers.

Gene 2018 Nov 29;688:26-33. Epub 2018 Nov 29.

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address:

Zinc finger antisense 1 (ZFAS1), a newly identified long non-coding RNA, is a transcript antisense to the 5' end of the protein-coding gene zinc finger NFX1-type containing 1 which hosts three C/D-box small nucleolar RNAs (SNORDs) within sequential introns: Snord12, Snord12b, and Snord12c. ZFAS1 is dysregulated and acts as either an oncogene or a tumor suppressor in different human malignancies. ZFAS1 has been implicated in many aspects of carcinogenesis, including proliferation, invasion, metastasis, apoptosis, cell cycle, and drug resistance. Read More

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November 2018

The Salvia miltiorrhiza NAC transcription factor SmNAC1 enhances zinc content in transgenic Arabidopsis.

Gene 2018 Nov 30;688:54-61. Epub 2018 Nov 30.

School of Life Sciences, Guizhou Normal University, No. 116, Baoshanbei Street, Guiyang 550001, Guizhou Province, PR China. Electronic address:

NAC transcription factors play important roles in plant biological processes, including plant development, environmental stress responses and element enrichment. A novel NAC transcription factor gene, designated SmNAC1, was isolated from Salvia miltiorrhiza. SmNAC1 was localized in the nucleus in onion protoplasts and exhibited transcriptional activation activities in yeast. Read More

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November 2018
3 Reads

Expression pattern of nanos, piwil, dnd, vasa and pum genes during ontogenic development in Nile tilapia Oreochromis niloticus.

Gene 2018 Nov 30;688:62-70. Epub 2018 Nov 30.

Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, UK. Electronic address:

Primordial germ cells (PGCs) are specified by maternally provided determinants in fish. PGCs migrate then into prospective gonadal sites during early development and give rise to germ cell lineage. PGC disrupted animals do not sexually mature which has a range of commercial as well as environmental benefits. Read More

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November 2018

Cervical cancer cell lines are sensitive to sub-erythemal UV exposure.

Gene 2018 Dec 2;688:44-53. Epub 2018 Dec 2.

Division of Biology, Kansas State University, Manhattan, KS, United States of America. Electronic address:

High risk human papillomavirus (HPV) infections are the causative agent in virtually every cervical cancer as well as a host of other anogenital and oropharyngeal malignancies. These viruses must activate DNA repair pathways to facilitate their replication, while avoiding the cell cycle arrest and apoptosis that can accompany DNA damage. HPV oncoproteins facilitate each of these goals, but also reduce genome stability. Read More

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December 2018
6 Reads

A homozygous RNF220 mutation leads to male infertility with small-headed sperm.

Gene 2018 Nov 27;688:13-18. Epub 2018 Nov 27.

Human Sperm Bank, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Morphological abnormality of spermatozoa head is a human infertility syndrome caused by spermatogenesis defects. The genetic alterations associated with macrozoospermia, globozoospermia and acephalic spermatozoa are relatively definite, whereas the underlying pathogenesis of small-headed sperm remains unclear. Here, we report a 32-year-old infertile male from a consanguineous family, who presented with 95% of small-headed sperm. Read More

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November 2018
4 Reads

The transcriptional coactivator YAP1 is overexpressed in osteoarthritis and promotes its progression by interacting with Beclin-1.

Gene 2018 Nov 26. Epub 2018 Nov 26.

Department of Sports Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address:

Osteoarthritis (OA) constitutes the most common disease of degenerative joints, with chondrocytes playing an important role in disease progression. However, the underlying pathobiological mechanisms have not been fully characterized. In this study, we investigated the role of Yes-associated protein 1 (YAP1)-regulated autophagy in chondrocyte proliferation, apoptosis, and differentiation. Read More

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November 2018

Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism.

Gene 2018 Nov 24;685:211-221. Epub 2018 Nov 24.

Department of Genetics, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, Paraná, Brazil.

Recent evidences had shown activation of TLR (toll-like receptors) and NLR (nod-like receptors) in response to imbalance in nutrients intake, such as lipid and glucose. The main aim of this study was to investigate possible associations between 11 SNPs in TLR2, TLR4, NLRC4, CARD8 and NEK7 genes and lipid and glucose metabolism. Sample was composed by healthy children and adolescents (n = 158) and adults (n = 115). Read More

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November 2018
3 Reads

Bioengineering-inspired three-dimensional culture systems: Organoids to create tumor microenvironment.

Gene 2018 Nov 24;686:203-212. Epub 2018 Nov 24.

Ege University, School of Medicine, Department of Medical Biology, 35100 Bornova, Izmir, Turkey. Electronic address:

In recent years, in vitro three-dimensional (3D) cell culture systems that better mimic in vivo physiology and tissue microenvironment have become important. It is used for the pre-clinical evaluation of the efficacy and safety profiles of new drug candidates developed especially for the treatment of various diseases including cancer. 3D cell culture techniques overcome the inadequacy of conventional two-dimensional (2D) cell culture models as they are much more informative than the 2D systems. Read More

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November 2018

The protective role of intermedin in promoting angiogenesis during renal fibrosis.

Gene 2018 Nov 22;688:34-43. Epub 2018 Nov 22.

Department of Nephrology, Shanxi Provincial People's Hospital, The Affiliated People's Hospital of Shanxi Medical University, Shanxi Kidney Disease Institute, Taiyuan, Shanxi 030012, China.

Background: Renal fibrosis promotes the progression of chronic renal disease to end-stage renal disease. Microvascular damage and loss play an important role in renal fibrosis. Intermedin (IMD) is expressed mainly in the heart and kidney. Read More

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November 2018
4 Reads

An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells.

Gene 2018 Nov 22;686:146-159. Epub 2018 Nov 22.

Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute Technology Guwahati, Guwahati 781039, Assam, India. Electronic address:

Over a decade ago, a landmark study that reported derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming fibroblasts has transformed stem cell research attracting the interest of the scientific community worldwide. These cells circumvent the ethical and immunological concerns associated with embryonic stem cells, and the limited self-renewal ability and restricted differentiation potential linked to adult stem cells. iPSCs hold great potential for understanding basic human biology, in vitro disease modeling, high-throughput drug testing and discovery, and personalized regenerative medicine. Read More

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November 2018
3 Reads

Long non-coding RNA TP73‑AS1 promotes colorectal cancer proliferation by acting as a ceRNA for miR‑103 to regulate PTEN expression.

Gene 2018 Nov 22;685:222-229. Epub 2018 Nov 22.

Department of Colorectal & Anal Surgery, Hepatobiliary & Enteric Surgery Research Center of Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

There is an increasing evidence that long non-coding RNAs (lncRNAs) play an important role in tumorigenesis and cancer progression. This study focused on the functional role of P73 antisense RNA 1T (TP73‑AS1), a lncRNA, in colorectal cancer (CRC). We found that TP73‑AS1 expression was significantly low in CRC tissues and cells, and high TP73‑AS1 expression was negatively associated with TNM stage, prognosis, overall survival, and disease-free survival in the CRC patients. Read More

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November 2018
3 Reads

Curcumin modulates the angiogenic potential of human endothelial cells via FAK/P-38 MAPK signaling pathway.

Gene 2018 Nov 23;688:7-12. Epub 2018 Nov 23.

Neurophysiology Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Many phyto-compounds are found to have anti-angiogenesis property. Curcumin, a natural polyphenol, has been used as medicinal plant for years with different biological activities. Here, we investigated the effect of curcumin on angiogenesis potential of human endothelial cells. Read More

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November 2018
5 Reads
2.140 Impact Factor

Polymorphism rs4787951 in IL-4R contributes to the increased risk of renal cell carcinoma in a Chinese population.

Gene 2018 Nov 23;685:242-247. Epub 2018 Nov 23.

Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:

Objective: Interleukins are important molecules involved in tumor formation. In this study, the association between renal cell carcinoma (RCC) risk and single nucleotide polymorphisms (SNPs) on IL-4/IL-13/IL-4R was assessed.

Methods: We recruited 620/623 cases/controls and conducted a case-control study. Read More

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November 2018
3 Reads

Genome-wide identification and characterization of the Dof gene family in cassava (Manihot esculenta).

Gene 2018 Nov 22;687:298-307. Epub 2018 Nov 22.

Danzhou Investigation & Experiment Station of Tropical Crops, Ministry of Agriculture and Rural Affairs, Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, PR China.

Dof proteins comprise a plant-specific transcription factor family involved in regulation of many plant processes. Despite their diverse roles, little information is available in cassava (Manihot esculenta, Euphorbiaceae), the sixth major staple crop in the world. This study presents the first genome-wide identification of Dof family genes in cassava, resulting in 45 family members that are unevenly distributed across 17 out of the 18 chromosomes. Read More

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November 2018

Insight into long noncoding competing endogenous RNA networks in hepatic fibrosis: The potential implications for mechanism and therapy.

Gene 2018 Nov 22;687:255-260. Epub 2018 Nov 22.

Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China. Electronic address:

Mounting evidence has shown that long noncoding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) in distinct physiological and pathological states. The activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis (HF). LncRNAs have recently been revealed to be involved in HSC activation as ceRNAs. Read More

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November 2018
1 Read

RNA-Seq analysis of gynoecious and weak female cucumber revealing the cell cycle pathway may regulate sex determination in cucumber.

Gene 2018 Nov 22;687:289-297. Epub 2018 Nov 22.

Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China; Guangdong Key Laboratory for New Technology Research of Vegetables, Guangzhou 510640, China. Electronic address:

This study aims to investigate key genes involved in molecular regulatory networks of cucumber sex determination. Genome-wide high-throughput RNA sequencing was performed for young apical buds of gynoecious and weak female cucumber at three growth stages (one-leaf one-bud, three-leaf one-bud, and five-leaf one-bud). Seven comparisons from the same cultivar at three different stages and at the same stage between the two cultivars were analyzed, and the results revealed that compared with differentially expressed genes (DEGs) in weak female cucumber, more genes were upregulated at the one-leaf one-bud stage and downregulated at the three-leaf one-bud stage in gynoecious cucumber. Read More

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November 2018
1 Read

Genetic variability and oncogenic risk association of human papillomavirus type 58 E6 and E7 genes in Taizhou area, China.

Gene 2018 Nov 22;686:171-176. Epub 2018 Nov 22.

Laboratory of Gynecologic Oncology, Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China. Electronic address:

It is well recognized that the association of human papillomavirus (HPV) and cervical carcinogenesis is based on the presence of HPV DNA sequence. The E6 and E7 oncoproteins encoded by high-risk HPV types play a key role in carcinogenesis. HPV58 type accounts for a larger share of cervical disease in China, whereas data on HPV58 genetic variability in China is limited. Read More

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November 2018
5 Reads

Molecular identification, phylogenomic characterization and expression patterns analysis of the LIM (LIN-11, Isl1 and MEC-3 domains) gene family in pear (Pyrus bretschneideri) reveal its potential role in lignin metabolism.

Gene 2018 Nov 20;686:237-249. Epub 2018 Nov 20.

School of Life Science, Anhui Agricultural University, No. 130, Changjiang West Road, Hefei 230036, China. Electronic address:

Lignin is the main component of stone cells, which are a key factor in determining pear quality. Therefore, modification of lignin biosynthesis has important implications for regulating stone cell formation. LIMs are involved in plant development, stress response and metabolism. Read More

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November 2018
1 Read

Generalizability and applicability of results obtained from populations of European descent regarding the effect direction and size of HDL-C level-associated genetic variants to the Hungarian general and Roma populations.

Gene 2018 Nov 22;686:187-193. Epub 2018 Nov 22.

MTA-DE Public Health Research Group of the Hungarian Academy of Sciences, Faculty of Public Health, University of Debrecen, Debrecen 4028, Hungary; Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen 4028, Hungary; WHO Collaborating Centre on Vulnerability and Health, Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen 4028, Hungary. Electronic address:

Objectives: Large-scale association studies that mainly involve European populations identified many genetic loci related to high-density lipoprotein cholesterol (HDL-C) levels, one of the most important indicators of the risk for cardiovascular diseases. The question with intense speculation of whether the effect estimates obtained from European populations for different HDL-C level-related SNPs are applicable to the Roma ethnicity, the largest minority group in Europe with a South Asian origin, was addressed in the present study.

Design: The associations between 21 SNPs (in the genes LIPC(G), CETP, GALNT2, HMGCP, ABCA1, KCTD10 and WWOX) and HDL-C levels were examined separately in adults of the Hungarian general (N = 1542) and Roma (N = 646) populations by linear regression. Read More

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November 2018
1 Read

High incidence of co-existing factors significantly modifying the phenotype in patients with Fabry disease.

Gene 2018 Nov 20;687:280-288. Epub 2018 Nov 20.

Gazi University Faculty of Medicine, Department of Pediatric Metabolic Disorders, Ankara, Turkey; Gazi University Faculty of Medicine, Department of Pediatric Genetic Disorders, Ankara, Turkey. Electronic address:

Fabry disease results from deficiency of the lysosomal enzyme alpha-galactosidase A. The families of 11 index cases were screened by enzyme and molecular assays. Further clinical and laboratory investigations were carried out in all cases. Read More

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November 2018
1 Read

Evaluation of miRNA-9 and miRNA-34a as potential biomarkers for diagnosis of breast cancer in Iranian women.

Gene 2018 Nov 20;687:272-279. Epub 2018 Nov 20.

Division of Genetics, Department of Biology, Faculty of Sciences, University of Isfahan, HezarJarib Street, Isfahan 81746-73441, Iran. Electronic address:

Purpose: MicroRNAs are involved in diverse biological processes and their dysregulation is a common event in various diseases including breast cancer. Breast cancer is a major threat to women's health. This study was designed to examine the expression levels of miR-9 and miR-34a in breast tumor tissue samples and plasma of breast cancer patients, compare their expression pattern between tissue samples and plasma samples of patients and analyze their relationship with tumor clinical features. Read More

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November 2018
3 Reads

The pivotal oncogenic role of Jab1/CSN5 and its therapeutic implications in human cancer.

Gene 2018 Nov 20;687:219-227. Epub 2018 Nov 20.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University and Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410008, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China. Electronic address:

Jab1/CSN5 is a conserved multifunctional protein involved in ubiquitin-mediated protein degradation. Deregulation of Jab1/CSN5 can exert dramatic effects on diverse cellular functions, including DNA repair, cell cycle control, apoptosis, angiogenesis, and signal transduction, all of which are critical for tumor development. Although increasing evidence has demonstrated that Jab1/CSN5 was overexpressed in a variety of human cancers and usually correlated with poor prognosis, little was known about the underlying regulatory principles that coordinated its function. Read More

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November 2018
2 Reads

Toll-like receptor 9 gene in Periodontal Disease - A promising biomarker.

Gene 2018 Nov 19;687:207-211. Epub 2018 Nov 19.

Department of Genetics and Biotechnology, School of Life and Environmental Sciences, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal; Centre of the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.

Periodontal Disease is an infectious and inflammatory disorder triggered mainly by periodontopathogenic bacteria, however, as a multifactorial disease, several factors modulate its progression, namely, genetic factors. Toll-like receptors (TLR) recognize molecular patterns present in pathogens and trigger an immune response against them. Thus, sequences variants in TLR genes seem to have the potential to modify the predisposition to Periodontal Disease and its progression. Read More

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November 2018
3 Reads

Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever.

Gene 2018 Nov 19;687:188-192. Epub 2018 Nov 19.

Faculty of Medicine, Tokat Gaziosmanpasa University, Department of Emergency Medicine, Tokat, Turkey.

Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever caused by Crimean Congo hemorrhagic fever virus (CCHFV). Paraoxonase-1 (PON1) is a high density lipoprotein (HDL)-binding protein which defense the body against oxidative stress. To investigate the role of the PON1 gene in CCHF, we screened the genotypes of two single nucleotide polymorphisms (Q192R [rs662] and L55M [rs854560]) in CCHF patients stratified according to course of severity and mortality by using PCR-based RFLP assay. Read More

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November 2018

The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction.

Gene 2018 Nov 17;687:173-187. Epub 2018 Nov 17.

Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium.

Histone modifications such as methylation of key lysine residues play an important role in embryonic development in a variety of organisms such as of Pacific oysters, zebrafish and mice. The action of demethylase ("erasers") and methyltransferase ("writers") enzymes regulates precisely the methylation status of each lysine residue. However, despite fishes being very useful model organisms in medicine, evolution and ecotoxicology, most studies have focused on mammalian and plant model organisms, and mechanisms underlying regulation of histones are unknown in fish development outside of zebrafish. Read More

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November 2018
3 Reads

The effect of Colchicum pusillum in human colon cancer cells via Wnt/β-catenin pathway.

Gene 2018 Nov 17;686:213-219. Epub 2018 Nov 17.

Department of Pharmacognosy-Phytotherapy, Faculty of Pharmacy, Near East University, Nicosia, Cyprus.

Objective: Colchicum pusillum belongs to the family Colchicaceae that particularly rich in tropolonic alkaloids. The aim of this study was to investigate the cytotoxicity and in vitro anticancer activity of Colchicum pusillum ethanolic extract on Colo-320 primer and Colo-741 metastatic colon adenocarcinoma cell lines.

Materials And Methods: Colchicum pusillum was collected and extracted with ethanol. Read More

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November 2018
5 Reads

Mutation analysis and pathogenicity identification of Mucopolysaccharidosis type IVA in 8 south China families.

Gene 2018 Nov 17;686:261-269. Epub 2018 Nov 17.

Department of Medical Genetics, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Mucopolysaccharidosis type IVA (MPS IVA) is a rare autosomal recessive lysosomal storage disorder caused by GALNS gene mutation. The aim of our study is to detect pathogenic variants for patients suspected of MPS IVA and set the base for subsequent prenatal diagnosis and preimplantation genetic diagnosis.

Methods: In our study, 9 MPS IVA patients from south China families were investigated. Read More

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November 2018
6 Reads

A panel of seven-miRNA signature in plasma as potential biomarker for colorectal cancer diagnosis.

Gene 2018 Nov 17;687:246-254. Epub 2018 Nov 17.

Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China; Department of Oncology, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou 215000, PR China. Electronic address:

Colorectal cancer (CRC) has been one of the most commonly diagnosed cancers in global. The differential expression profiles of microRNAs (miRNAs) in CRC plasma of patients have the potential to serve as a diagnostic biomarker. We conducted a four-stage study to identify the potential plasma miRNAs for CRC detection. Read More

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November 2018
2 Reads

MiR-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus.

Gene 2018 Nov 17;687:156-165. Epub 2018 Nov 17.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, USA.

MicroRNAs (miRNAs), small noncoding RNA molecules, have emerged as important factors during intervertebral disc degeneration. This study was to determine whether miR-202-3p regulates interleukin-1β (IL-1β)-induced expression of matrix metalloproteinase 1 (MMP-1) in human nucleus pulposus (NP) cells. Human NP cells were stimulated with IL-1β in vitro. Read More

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November 2018
3 Reads
2.138 Impact Factor

LncRNAs expression in adriamycin-induced rats reveals the potential role of LncRNAs contributing to chronic glomerulonephritis pathogenesis.

Gene 2018 Nov 17;687:90-98. Epub 2018 Nov 17.

Department of Pharmacy, The first Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, China.

Background: Chronic glomerulonephritis (CGN) is the most common form of primary glomerular disease with unclear molecular mechanisms. Currently, limited study on long non-coding RNAs (lncRNAs) in CGN is available. Our study aimed to identify potential lncRNAs and genes in the normal and adriamycin-induced CGN rats, which to explore the potential molecular mechanisms of CGN pathogenesis. Read More

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November 2018
2 Reads

Investigation of the synergistic effects of paclitaxel and herbal substances and endemic plant extracts on cell cycle and apoptosis signal pathways in prostate cancer cell lines.

Gene 2018 Nov 17;687:261-271. Epub 2018 Nov 17.

Ege University, Faculty of Medicine, Department of Urology, Izmir, Turkey.

Paclitaxel, which isolated from Taxus brevifolia, is recently started to be used against prostate cancer treatment and it is a very effective compound against cancer. In this study, we aimed to test the synergistic effect of two plant active compounds (sulphoraphane (SFN) and silymarin (SILY)) and several endemic plant species from Turkey (such as Phlomis leucophracta, Rubia davisiana, Alkanna tinctoria), which are known to have anticarcinogenic effect on androgen-independent PC3 and DU145, and androgen-dependent VCaP prostate cancer cell lines, with paclitaxel on the expression of cell cycle signaling and apoptosis regulator genes. Herbal substances and endemic herbal extracts were combined with Paclitaxel drug. Read More

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November 2018
5 Reads