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Adherence to Subcutaneous Allergen Immunotherapy in Southeast Turkey: A Real-Life Study.

Authors:
Tugba S Tat

Med Sci Monit 2018 Dec 11;24:8977-8983. Epub 2018 Dec 11.

Department of Allergy and Immunology, Dr. Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.

BACKGROUND Subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) and asthma is a very effective treatment, but adherence is still a serious problem. Studies addressing real-life adherence to SCIT are rare in the literature. The aim of this study was to evaluate the adherence to SCIT in AR and asthma. Read More

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December 2018

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin.

Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.

Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More

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December 2018

Prediction of ESRD in IgA Nephropathy Patients from an Asian Cohort: A Random Forest Model.

Kidney Blood Press Res 2018 Dec 7;43(6):1852-1864. Epub 2018 Dec 7.

Department of Nephrology, the Second Xiangya Hospital, Central South University, Key laboratory of Kidney disease and Blood Purification in Hunan Province, Changsha,

Background/aims: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied.

Methods: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Read More

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December 2018

A Study of Anti-Fat Bias among Danish General Practitioners and Whether This Bias and General Practitioners' Lifestyle Can Affect Treatment of Tension Headache in Patients with Obesity.

Obes Facts 2018 Dec 11;11(6):501-513. Epub 2018 Dec 11.

Department of Food and Resource Economics, University of Copenhagen, Copenhagen, Denmark.

Objectives: The study investigated whether treatment options for episodic tension-type headache vary among general practitioners (GPs) in Denmark depending on the patients' weight status and gender, and whether these decisions can be explained by the GPs' own anti-fat bias and lifestyle.

Methods: A cross-sectional questionnaire study with responses from 240 GPs on measures of anti-fat bias, healthiness of GPs' lifestyles, and reported patient treatment decisions.

Results: GPs tended to exhibit negative explicit and implicit anti-fat bias. Read More

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December 2018

Progression of Hearing Loss in the Aging Population: Repeated Auditory Measurements in the Rotterdam Study.

Audiol Neurootol 2018 Dec 11;23(5):290-297. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

We quantified changes in the auditory acuity of 675 aging adults (mean age 71.1 years, 52.0% female, mean follow-up 4. Read More

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December 2018

Proteinuria, Estimated Glomerular Filtration Rate and Urinary Retinol-Binding Protein as Clinical Predictors of Long-Term Allograft Outcomes in Transplant Glomerulopathy.

Kidney Blood Press Res 2018 Dec 7;43(6):1842-1851. Epub 2018 Dec 7.

Background/aims: We aimed to explore the associations between clinical parameters and long-term allograft outcomes in transplant glomerulopathy (TG) in a large retrospective cohort with long follow-up.

Methods: Clinical and laboratory data at biopsy from 180 cases of TG with an estimated glomerular filtration rate (eGFR)> 15ml/min/1.73m2 from January 2004 to December 2016 at our center were retrospectively analyzed. Read More

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December 2018

First-episode schizophrenia is associated with a reduction of HERV-K methylation in peripheral blood.

Psychiatry Res 2018 Dec 3;271:459-463. Epub 2018 Dec 3.

Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368 Wroclaw, Poland. Electronic address:

Human endogenous retroviruses (HERV) have been widely associated with schizophrenia etiology. Aberrant epigenetic processes may play a role in the etiology of schizophrenia. In this study, we tested whether schizophrenia patients at different stages of illness might present alterations in the levels of HERV-K methylation. Read More

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December 2018

Gender differences in correlates of cognition in first-episode psychosis.

Psychiatry Res 2018 Dec 3;271:412-420. Epub 2018 Dec 3.

Department of Psychiatry, University of Hong Kong, Hong Kong, China; State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China.

Studies of gender cognitive differences in schizophrenia have reported mixed results. This study examined cognitive correlates including demographics, symptoms and functioning in men and women in a large sample of first-episode adult-onset psychosis patients. Detailed demographic, clinical and functioning data were collected from 360 first-episode patients upon admission into an early intervention service for psychotic disorders. Read More

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December 2018
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Prenatal thallium exposure and poor growth in early childhood: A prospective birth cohort study.

Environ Int 2018 Dec 8;123:224-230. Epub 2018 Dec 8.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, People's Republic of China. Electronic address:

Background: Thallium (Tl) exposure remains a public health problem with potential impacts on humans. Studies have suggested that prenatal exposure to thallium may be associated with fetal growth, but no studies are known have explored its association with early childhood anthropometry.

Objective: To investigate the effects of prenatal Tl exposures on early child growth and development aged 0-2 years in a prospective birth cohort study. Read More

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December 2018

Action research improves services for child sexual abuse in one Caribbean nation: An example of good practice.

Child Abuse Negl 2018 Dec 8;88:225-234. Epub 2018 Dec 8.

Institute of Gender and Development Studies, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Background: Child sexual abuse (CSA) is a multi-dimensional problem. The search for best practice must consider the complexities surrounding CSA and its management in any particular society.

Objective: Data previously gathered from service providers on CSA service provision in Trinidad and Tobago identified key deficient issues in policy and practice. Read More

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December 2018

Childhood maltreatment and intimate partner violence victimization: A meta-analysis.

Child Abuse Negl 2018 Dec 8;88:212-224. Epub 2018 Dec 8.

Institute of Psychology, Renmin University of China, No. 59 Zhongguancun Street, Haidian District, Beijing, 100872, China. Electronic address:

Background: Intimate partner violence (IPV) victimization is a serious public health problem in the world. It is imperative to examine risk factors for IPV victimization.

Objective: This meta-analysis aimed to explore the relationship between childhood maltreatment (CM) and IPV victimization and investigate the moderating effects of gender and marital status. Read More

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December 2018

Linking organochlorine contaminants with demographic parameters in free-ranging common bottlenose dolphins from the northern Adriatic Sea.

Sci Total Environ 2018 Dec 4;657:200-212. Epub 2018 Dec 4.

Morigenos - Slovenian Marine Mammal Society, Kidričevo nabrežje 4, 6330 Piran, Slovenia.

Marine top predators, including marine mammals, are known to bio-accumulate persistent pollutants such as polychlorinated biphenyls (PCBs), a serious conservation concern for these species. Although PCBs declined in European seas since the 1970s-1980s ban, considerable levels still persist in European and Mediterranean waters. In cetaceans, stranded animals are a valuable source of samples for pollutant studies, but may introduce both known and unknown biases. Read More

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December 2018

Sex differences in the temporal neuromolecular and synaptogenic effects of the rapid-acting antidepressant drug ketamine in the mouse brain.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Biology & Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, Ohio, USA. Electronic address:

Preclinical evidence suggests that ketamine's rapid and sustained antidepressant actions are due to the induction of synaptogenesis in the medial prefrontal cortex (mPFC) and the hippocampus (HIPP), two brain regions implicated in the pathophysiology of major depression. However, research on the neurobiological effects of ketamine has focused almost exclusively on males. Findings from our group and others indicate that female rodents are more reactive to ketamine's antidepressant effects, since they respond to lower doses in antidepressant-predictive behavioral models. Read More

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December 2018

Genes known to escape X chromosome inactivation predict co-morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 11. Epub 2018 Dec 11.

Institute for Trauma Recovery, University of North Carolina, Chapel Hill, North Carolina.

Co-morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision, are associated with greater disability than either outcome alone, and are more prevalent in women than men. In the current study we assessed for evidence that gene transcripts originating from the X chromosome contribute to sex differences in vulnerability to CMSP and PTSS after motor vehicle collision. Nested samples were drawn from a longitudinal study of African American individuals, and CMSP (0-10 numeric rating scale) and PTSS (impact of events scale, revised) outcomes were assessed 6 months following motor vehicle collision. Read More

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December 2018
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Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 9. Epub 2018 Dec 9.

LIM23, Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

The male-biased prevalence of certain neurodevelopmental disorders and the sex-biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP-seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. Read More

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December 2018

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
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Major bleeding with antithrombotic agents: a 2012-2015 study using the French nationwide Health Insurance Database (SNIIRAM) linked to emergency departments records within five areas. Rationale and design of SACHA study.

Fundam Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

CHU de Brest, F-29200, France.

Bleeding represents the most recognised and feared complications of antithrombotic drugs including oral anticoagulants. Previous studies showed inconsistent results on the safety profile. Among explanations, bleeding definition could vary and classification bias exist related to the lack of medical evaluation. Read More

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December 2018

Hind- and Midfoot Bone Morphology Varies with Foot Type and Sex.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

RR&D Center for Limb Loss and MoBility, VA Puget Sound, Seattle, WA.

Foot type has been associated with pain, injury, and altered gait mechanics. Morphological variations in foot bones due to foot type variation may impact surgical and therapeutic treatments. The purpose of this study was to utilize principal component analysis (PCA) to determine how morphology of the hind- and midfoot bones differs among foot types and sex. Read More

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December 2018

Physical activity energy expenditure and cardiometabolic health in three rural Kenyan populations.

Am J Hum Biol 2018 Dec 10:e23199. Epub 2018 Dec 10.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Objectives: Physical activity is beneficial for metabolic health but the extent to which this may differ by ethnicity is still unclear. Here, the objective was to characterize the association between physical activity energy expenditure (PAEE) and cardiometabolic risk among the Luo, Kamba, and Maasai ethnic groups of rural Kenya.

Methods: In a cross-sectional study of 1084 rural Kenyans, free-living PAEE was objectively measured using individually-calibrated heart rate and movement sensing. Read More

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December 2018

Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Digestive, Hangzhou Traditional Chinese Medical Hospital, Hangzhou, China.

Objective: To explore the changes of Sonic Hedgehog (Shh) signaling pathway in the stomach mucosa during the formation of gastric precancerous lesions.

Methods: A total of 72 suckling rats in half genders were randomly and equally divided into the normal group and model group. The rats in the model group were administered with 0. Read More

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December 2018

Exercise worsening of electromechanical disturbances: a predictor of arrhythmia in long qt syndrome.

Clin Cardiol 2018 Dec 9. Epub 2018 Dec 9.

Institute of Public Health and Clinical Medicine, Umea University, Umea, Sweden.

Background: Electromechanical (EM) coupling heterogeneity is significant in long QT syndrome (LQTS), particularly in symptomatic patients; EM window (EMW) has been proposed as an indicator of interaction and a better predictor of arrhythmia than QTc.

Aim: To investigate the dynamic response of EMW to exercise in LQTS and its predictive value of arrhythmia.

Methods: Forty-seven LQTS carriers (45±15 years, 20 with arrhythmic events) and 35 controls underwent exercise echocardiogram. Read More

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December 2018
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IN THIS ISSUE.

Authors:

Perspect Sex Reprod Health 2018 Dec;50(4):153

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December 2018

Bone Safety During the First Ten Years of Gender-Affirming Hormonal Treatment in Transwomen and Transmen.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands.

Concerns about the effects of gender-affirming hormonal treatment (HT) on bone mineral density (BMD) in transgender people exist, particularly regarding the decrease in estrogen concentrations in transmen. Although it is known that HT is safe for BMD in the short term, long-term follow-up studies are lacking. Therefore this study aimed to investigate the change in BMD during the first 10 years of HT, to determine whether HT is safe and if assessing BMD during HT is necessary. Read More

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December 2018
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Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.

Am J Hum Biol 2018 Dec 10:e23192. Epub 2018 Dec 10.

Programa Integral de Atención a la Obesidad, Secretaria de Educación del Gobierno del Estado de Yucatán, Mérida, Yucatán, Mexico.

Objectives: Genetic variation of the fat mass and obesity associated gene (FTO) has been identified as a risk factor for obesity and obesity traits. Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity.

Methods: We included 318 school-aged children with obesity or overweight status (body mass index [BMI]: >85th percentile) and 303 children with normal weight (BMI: 15th-85th percentile). Read More

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December 2018

Determinants of emergency department utilization for non-traumatic dental conditions in Massachusetts.

J Public Health Dent 2018 Dec 10. Epub 2018 Dec 10.

Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.

Objectives: To study the determinants of emergency department (ED) utilization for non-traumatic dental conditions (NTDCs) by adults in Massachusetts.

Methods: We analyzed patient-level factors associated with ED utilization for NTDCs in Massachusetts during 2013, using the Massachusetts All Payer Claims Dataset. The primary independent variables of interest were use of preventive dental service in the year preceding the ED visit and dental insurance coverage. Read More

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December 2018

Patterns of structural change in gonads of the divine dwarfgoby Eviota epiphanes as they sexually transition.

J Fish Biol 2018 Dec 7. Epub 2018 Dec 7.

University of Hawai'i at Mānoa 2538 McCarthy Mall Edmondson Hall 216 Honolulu, Hawai'I, USA.

This study documents changes in gonadal structure for the serial hermaphrodite (or bidirectional sex changer) divine dwarfgoby Eviota epiphanes (family Gobiidae) as individuals transition in both directions. To evaluate transitional gonad morphology, individuals actively producing the same gamete type (oocytes or sperm) were set up into pairs and euthanised over a period of 14 days to get a time series of morphological changes during gonad transformation. Results from this study show that rapid changes in the gonad take place at a structural level as individuals change their reproductive function and gamete production. Read More

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December 2018

Diabetic retinopathy in people with Type 2 diabetes and obesity treated by Roux-en-Y gastric bypass compared with non-operated controls: with focus on the role of diabetes remission in a cross-sectional and a 6-year follow-up study.

Diabet Med 2018 Dec 7. Epub 2018 Dec 7.

Departments of Endocrinology and Internal Medicine.

Aim: Whether or not Roux-en-Y gastric bypass (RYGB) and the derived metabolic improvements are beneficial to diabetic retinopathy is controversial. We aimed to determine the presence and development of retinopathy in individuals with obesity and Type 2 diabetes treated by RYGB compared with non-operated controls, and to determine the role of diabetes remission.

Methods: We graded fundus photography using the Wisconsin Epidemiologic Study of Diabetic Retinopathy in 96 individuals with obesity and Type 2 diabetes treated by RYGB 6 years after surgery compared with 48 non-operated controls. Read More

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December 2018

A new method to quantify mandibular corpus shape in extant great apes and its potential application to the hominoid fossil record.

Am J Phys Anthropol 2018 Dec 7. Epub 2018 Dec 7.

Department of Anthropology, University of Toronto, St. Toronto, Ontario, Canada.

Objectives: Mandibular corpus robusticity (corpus breadth/corpus height) is the most commonly utilized descriptor of the mandibular corpus in the great ape and hominin fossil records. As a consequence of its contoured shape, linear metrics used to characterize mandibular robusticity are inadequate to quantify the shape of the mandibular corpus. Here, we present an alternative to the traditional assessment of mandibular shape by analyzing the outline of the mandibular corpus in cross-section using landmarks and semilandmarks. Read More

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December 2018

Exploring the use of resources to support gender equality in Australian workplaces.

Health Promot J Austr 2018 Dec 8. Epub 2018 Dec 8.

Centre for Health through Action on Social Exclusion (CHASE), Teaching and Learning Coordinator (Internationalisation), School of Health & Social Development, Faculty of Health, Deakin University, Melbourne Burwood Campus, 221 Burwood Highway, Burwood, VIC, 3125.

Issue Addressed: Numerous resources exist to support workplaces to undertake gender equality work, however, it is often unclear which existing resources are being utilised by Australian workplaces. One group that can provide insight into the use of existing resources is the professionals who have undertaken gender equality work in their organisation.

Methods: Purposive sampling was used to identify informants with experience undertaking gender equality work. Read More

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December 2018

Insulin function in obese children within the low and high ranges of impaired fasting glycemia.

Pediatr Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Stockholm, Sweden.

Background: Impaired fasting glycemia (IFG) reflects an intermediate hyperglycemia in the fasting state. Which fasting glucose level that actually is associated with impaired insulin-glucose homeostasis in children and adolescents with obesity is unknown.

Objective: The aim of this study was to investigate how insulin and glucose homeostasis in children and adolescents with obesity in Sweden varies within different fasting glucose levels in the non-diabetic range. Read More

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December 2018

The risk of cancer attributable to diagnostic medical radiation: Estimation for France in 2015.

Int J Cancer 2018 Dec 8. Epub 2018 Dec 8.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France, 69372.

Although medical ionizing radiation (IR) has clear clinical benefits, it is an established carcinogen. This study estimates the number of new cancer cases in France in 2015 attributable to IR exposure from medical procedures. Exposures from external (X-rays, CT scans, interventional radiology) and internal (nuclear medicine) sources were considered. Read More

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December 2018

Recommendations for Iliosacral Screw Placement in Dysmorphic Sacrum based on Modified In-Out-In Corridors.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

Clinic of Orthopaedics and Sportsorthopaedics, Klinikum rd. Isar, Technische Universität München, Munich, Germany.

(1) Can iliosacral osseous corridor diameters in sacral dysmorphism be enlarged by in-out-in screw placement at the posterior iliosacral recessus? (2) Are lumbosacral transitional vertebra (LSTV) the anatomical cause for sacral dysmorphism? (3) Are there sex-specific differences in sacral dysmorphism? 594 multislice CT scans were screened for sacral dysmorphism and 55 data-sets selected. Each pelvis was segmented manually and cylindrical iliosacral corridors (S1 and S2 vertebra) were semi-automatically determined. Corridor trajectories, -diameters and -lengths were measured. Read More

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December 2018

Volume change in infrapatellar fat pad is associated not with obesity but with cartilage degeneration.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

Department of General Medical Services, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Infrapatellar fat pad has been implicated in knee osteoarthritis. We examined whether infrapatellar fat pad volume is associated with quantitative cartilage changes using magnetic resonance imaging T1ρ mapping. Fifty-eight knees of knee pain patients (19 men, 39 women, mean age 57. Read More

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December 2018

Increased risk of postoperative complications after total thyroidectomy with Graves' disease.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Ewha Womans University Medical Center, Seoul, South Korea.

Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear.

Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group).

Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Read More

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December 2018

Accessing free quality health care services and premature death.

Int J Health Plann Manage 2018 Dec 11. Epub 2018 Dec 11.

Petroleum Industry Health Organization Headquarters, Tehran, Iran.

Background: The type of health insurance may affect the likelihood of mortality of insured people. We conducted this study to determine if accessing free quality health care services could decrease the premature mortality of people in a developing country.

Methods: In a multicenter cross sectional study, "years-life-lost" (YLL) due to premature death was evaluated in 202 671 insured people residing in six large regions in Iran. Read More

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December 2018

Characterization of Campylobacter jejuni, Campylobacter upsaliensis, and a novel Campylobacter sp. in a captive non-human primate zoological collection.

J Med Primatol 2018 Dec 9. Epub 2018 Dec 9.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Background: The aim of this study was to longitudinally investigate the prevalence and characterization of Campylobacter spp. from non-human primates primate (NHP) with a history of endemic diarrhea housed at Como Park Zoo.

Methods: Fecal samples from 33 symptom-free NHP belonging to eight different species were collected weekly for 9 weeks. Read More

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December 2018
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Infants who die in shared sleeping situations differ from those who die while sleeping alone.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

Discipline of Anatomy and Pathology, Adelaide Medical School, The University of Adelaide, Adelaide, Australia.

Aim: To determine whether there are differences between infants who are sharing a sleeping surface with others, compared to those who die alone.

Methods: A literature review was undertaken of pubmed and google scholar databases using search terms: sudden infant death syndrome, SIDS, cosleeping and overlaying.

Results: Statistically significant differences were found between the two groups in the sex ratios, and in staining of brain sections for β-amyloid precursor protein (β-APP), glial fibrillary acidic protein (GFAP) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL). Read More

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December 2018

Differential Mucosal Gene Expression Patterns in Candida-Associated, Chronic Oral Denture Stomatitis.

J Prosthodont 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY.

Purpose: Denture stomatitis is a common condition manifested by inflammation of the oral mucous membrane beneath a denture. The objective of this study was to compare the transcriptome of human palatal mucosa with chronic oral stomatitis-associated Candida albicans infection to that of healthy oral mucosa.

Materials And Methods: Oral palatal biopsies were obtained from 17 healthy and 15 C. Read More

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December 2018

Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Aim: We aimed to assess the influence of fasting insulin resistance on metabolically healthy obesity (MHO) prevalence in adolescents and to identify associated factors.

Methods: This retrospective, registry-based, cross-sectional study included 418 (51.9% girls) 10-18 year-old adolescents with obesity from a tertiary outpatient clinic in Sao Paulo, Brazil, between 2009 and 2013. Read More

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December 2018
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Interleukin-17 producing T cells and interleukin-17 mRNA expression in periodontitis and longstanding gingivitis lesions.

J Periodontol 2018 Dec 7. Epub 2018 Dec 7.

Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Sweden.

Background: T helper17 cells (Th17) are key targets in the evaluation of differences between "destructive" and "non-destructive" periodontal lesions. The aim of the present study was to analyze the density of interleukin-17 (IL-17) producing T cells and IL-17 mRNA expression in lesions representing severe periodontitis and longstanding gingivitis.

Methods: Two groups of patients were recruited. Read More

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December 2018

Population Pharmacokinetic Analysis of Decitabine in Pediatric Patients With Acute Myeloid Leukemia.

J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Established Products, Janssen Research & Development, Titusville, NJ, USA.

Dacogen, the formulated product of the pharmaceutically active agent decitabine (5 aza-2'-deoxycytidine), is approved for treatment of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML). The current analysis was performed to characterize the pharmacokinetics of decitabine in pediatric patients with AML and evaluate their consistency with the PK in adult patients. A population pharmacokinetic model was developed by pooling decitabine concentration-time data from 5 adult (AML and MDS) and 2 pediatric (AML) studies. Read More

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December 2018

Gender differences in mental health and substance use disorders and related healthcare services utilization.

Am J Addict 2018 Dec 7. Epub 2018 Dec 7.

School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts.

Background And Objectives: Pathological gambling often co-occurs with other psychiatric disorders. Gender differences in treatment-seeking behaviors among patients with pathological gambling diagnosis remain poorly understood. This study assessed gender differences in healthcare services utilization in patients seeking treatment for pathological gambling, substance use, and mental health co-occurring conditions. Read More

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December 2018

Sex-by-formulation interaction in bioequivalence studies: the importance of formulations and experimental conditions.

Br J Clin Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Pharmaceutical Sciences Department - Faculty of Chemistry, Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE) - Universidad de la República, Uruguay.

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December 2018

Pre-operative factors influencing post-operative outcomes from MyoRing implantation in keratoconus.

Clin Exp Optom 2018 Dec 7. Epub 2018 Dec 7.

Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: To identify pre-operative factors that influence post-operative performance of a full-ring intra-corneal implant (MyoRing) for the management of keratoconus.

Method: In a retrospective study, medical records of 70 keratoconus eyes of 70 consecutive surgical patients with a mean age of 28.54 ± 6. Read More

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December 2018

Liver Stiffness Measured by 2-Dimensional Shear Wave Elastography: Prospective Evaluation of Healthy Volunteers and Patients With Liver Cirrhosis.

J Ultrasound Med 2018 Dec 11. Epub 2018 Dec 11.

Department Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany.

Objectives: We aimed to establish normal values for liver stiffness measurement, performed by 2-dimensional shear wave elastography (LOGIQ E9; GE Healthcare, Wauwatosa, WI), in healthy volunteers, patients with nonhepatic morbidities, and patients with histologically confirmed liver cirrhosis.

Methods: A total of 175 participants were included between July 2016 and February 2018. Three cohorts were analyzed: healthy volunteers (n = 68), patients with healthy livers but nonhepatic morbidities (n = 57), and patients with liver cirrhosis (n = 50). Read More

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December 2018
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Physiological changes after colorectal surgery suggest anastomotic leakage is an early event: a retrospective cohort study.

Colorectal Dis 2018 Dec 11. Epub 2018 Dec 11.

St Mark's Hospital, Watford Road, Harrow, Middlesex, HA1 3UJ.

Introduction: Anastomotic leakage (AL) is often identified 7-10 days after colorectal surgery. However, in retrospect, patients may have abnormalities evident much earlier. This study aims to identify the clinical time-point when AL occurs. Read More

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December 2018

The Effects of a Functional Three-dimensional (3D) Printed Knee Joint Simulator in Improving Anatomical Spatial Knowledge.

Anat Sci Educ 2018 Dec 7. Epub 2018 Dec 7.

Division of Industrial Design, School of Design and Environment, National University of Singapore, Singapore.

In recent decades, three-dimensional (3D) printing as an emerging technology, has been utilized for imparting human anatomy knowledge. However, most 3D printed models are rigid anatomical replicas that are unable to represent dynamic spatial relationships between different anatomical structures. In this study, the data obtained from a computed tomography (CT) scan of a normal knee joint were used to design and fabricate a functional knee joint simulator for anatomical education. Read More

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December 2018

Six years of experience using an advanced algorithm for botulinum toxin application.

J Cosmet Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Albany Medical School, Albany, New York.

Background: Botulinum toxin (BTX) products continue to be widely used for facial rejuvenation. Variables to consider prior to BTX treatment include the anatomical area to be treated, gender, muscle mass, ethnicity, skin thickness, and the effects of aging.

Objective: To describe a treatment algorithm which has been developed for facial rejuvenation to help physicians to easily and systematically customize BTX treatment, and to describe its use in a large number of patients. Read More

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December 2018
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Determinants for Meaningful Clinical Improvement of Pain and Health-Related Quality of Life After Spinal Cord Stimulation for Chronic Intractable Pain.

Neuromodulation 2018 Dec 10. Epub 2018 Dec 10.

Center for Applied Neuroscience (CeNAp), University Hospital (HU), Federal University of Santa Catarina State (UFSC), Florianópolis, SC, Brazil.

Objectives: Previous studies demonstrated significant improvement in mean pain scores and quality of life (QOL) scales in patients with chronic pain who underwent spinal cord stimulation (SCS). However, the number of individuals who experience relevant improvements in QOL, termed the meaningful clinical improvement (MCI), is not known. The present study investigated changes in pain measurements based on MCI after SCS. Read More

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December 2018
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