Search Our Scientific Publications & Authors

Gut 2021 Apr 13. Epub 2021 Apr 13.

Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Andhra Pradesh, India.

Background: The majority of endoscopic antireflux procedures for GERD are cumbersome to use and randomised long-term data are sparse. We conducted such a trial to determine the efficacy and safety of a novel, easy to use endoscopic full-thickness fundoplication (EFTP) device in patients with GERD.

Design: Patients with proton pump inhibitor (PPI)-dependent GERD were randomised to either EFTP or a sham procedure in 1:1 ratio. Read More

Diagnostics (Basel) 2021 Mar 14;11(3). Epub 2021 Mar 14.

Department of Surgery, 3-rd Surgery Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.

Colorectal cancer is the third most common and second most lethal tumor globally, causing 900,000 deaths annually. In this research, a computer aided diagnosis system was designed that detects colorectal cancer, using an innovative dataset composing of both numeric (blood and urine analysis) and qualitative data (living environment of the patient, tumor position, T, N, M, Dukes classification, associated pathology, technical approach, complications, incidents, ultrasonography-dimensions as well as localization). The intelligent computer aided colorectal cancer diagnosis system was designed using different machine learning techniques, such as classification and shallow and deep neural networks. Read More

Cancer Epidemiol Biomarkers Prev 2021 Mar 2. Epub 2021 Mar 2.

Department of Gastroenterology, University of Tokyo.

Background: ABO blood group has been associated with risks of various malignancies including pancreatic cancer. No study has evaluated the association of ABO blood group with incidence of pancreatic carcinogenesis during follow-up of patients with intraductal papillary mucinous neoplasms (IPMNs).

Methods: Among 3,164 patients diagnosed with pancreatic cysts at the University of Tokyo from 1994 through 2019, we identified 1,815 IPMN patients with available data on ABO blood group. Read More

Aliment Pharmacol Ther 2021 03 5;53(6):696-703. Epub 2021 Feb 5.

Maccabi Institute for Research & Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.

Background: Incidence rate and temporal trends in coeliac disease and coeliac disease autoimmunity incidence vary worldwide with most data available from North American and European countries.

Aims: To explore temporal trends in incidence of coeliac disease autoimmunity and their relation to increase in screening tests in Israel.

Methods: A large retrospective population-based study was conducted in Maccabi Healthcare Services, a 2. Read More

Medicine (Baltimore) 2020 Dec;99(52):e23868

Gatroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6, 1st Section, Fangxingyuan, Fangzhuang, Fengtai District.

Background: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a kind of functional gastrointestinal disorder with obscure pathogenesis, and exploration about differential gene expression and cell heterogeneity of T lymphocytes in peripheral blood in IBS-D patients still remains unknown. Clinicians tend to use symptomatic treatment, but the efficacy is unstable and symptoms are prone to relapse. Traditional Chinese Medicine (TCM) is used frequently in IBS-D with stable and lower adverse effects. Read More

BMJ Open Gastroenterol 2020 10;7(1)

Gatroenterology and Hepatology, Loma Linda University, Loma Linda, California, USA

Objective: The range of normal serum alkaline phosphatase is not well defined. We used data from the National Health and Nutrition Examination Survey from 2009 to 2016 to generate normal ranges for a racially diverse sample of healthy adults.

Methods: Respondents 18 years or older were included. Read More

Pathol Oncol Res 2020 Oct 24;26(4):2509-2521. Epub 2020 Jun 24.

Department of Biopathology, Academic Hospital, rue du Général Koenig, 51100, Reims, France.

Describe clinical, histological and molecular charatcteristics and prognosis values of the serrated candidate markers AnnexinA10 and Gremlin1 in colon adenocarcinomas. Immunohistochemical expression of AnnexinA10 and Gremlin1 was evaluated on 346 colonic adenocarcinomas. Clinicopathological, molecular features and prognostic characteristics were then evaluated. Read More

Dig Endosc 2020 Sep 12;32(6):844-850. Epub 2020 Aug 12.

Department of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, USA.

Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is the etiologic agent causing the disease Corona Virus Disease 19 (COVID-19), resulting in a worldwide pandemic. Non-emergent endoscopy services have been disrupted as incidence and hospitalizations were rising. It is anticipated that the peak incidence may be leveling off in many parts of the world, but there is a concern for resurgence of the virus activity. Read More

J Crohns Colitis 2020 May 15. Epub 2020 May 15.

Rheumatology Unit, IRCCS Sacro Cuore Don Calabria, Negrar, Italy.

Background And Aimes: Both peripheral and axial spondyloarthritis (SpA) occurs in inflammatory bowel disease (IBD) and represents the commonest extra-intestinal manifestation. We aimed to develop an easy and quick questionnaire through psycometric analysis to identify peripheral and axial SpA in IBD patients within an integrated combined multidisciplinary rheumatological-gastroenterology clinic.

Methods: Initially, SpA-IBD experts generated a 42-item list covering SpA manifestations including spinal, articular and entheseal involvement. Read More

J Neuroimmune Pharmacol 2020 12 16;15(4):794-800. Epub 2020 Mar 16.

Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.

The Leucine Rich Repeat Kinase 2 (LRRK2) is one of causative genes of familial Parkinson's disease (PD). The M2397T polymorphism in LRRK2 is genetically associated with sporadic Crohn's disease (CD). LRRK2 is expressed in human CD14 monocytes, induced by interferon-γ (IFN-γ) and suppresses inflammatory activation. Read More

J Gastrointestin Liver Dis 2020 Mar 13;29(1). Epub 2020 Mar 13.

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Regional Institute of Gastroenterology (IRGH) Cluj-Napoca, Cluj-Napoca, Romania.

Harefuah 2019 Dec;158(12):822-825

Division of Gastroenterology, Beilinson Hospital, Rabin Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: In the last decade, the number of bariatric surgery procedures increased dramatically in Israel similar to what has occurred worldwide. Bariatric surgery procedures have a proven efficacy in the treatment of morbid obesity. However, post-operative complications that involve the gastrointestinal tract may occur. Read More

J Crohns Colitis 2020 May;14(4):480-489

Humanitas Clinical and Research Center, Gastroenterology Department, Rozzano, Milan, Italy.

Background: Interstitial lung [ILD] disease and granulomatous lung disease [GLD] are rare respiratory disorders that have been associated with inflammatory bowel disease [IBD]. Clinical presentation is polymorphic and aetiology is unclear.

Methods: This was an ECCO-CONFER project. Read More

Hepatol Int 2019 11 9;13(6):826-828. Epub 2019 Oct 9.

Department Of Internal Medicine, Inje University College of Medicine, Busan, South Korea.

The article Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update, written by [Shiv Sarin], was originally published electronically on the publisher's internet portal (currently SpringerLink) on June 06, 2019 without open access. Read More

Hepatol Int 2019 Jul 6;13(4):353-390. Epub 2019 Jun 6.

Department Of Internal Medicine, Inje University College of Medicine, Busan, South Korea.

The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the "APASL ACLF Research Consortium (AARC)" was formed in 2012, which continued to collect prospective ACLF patient data. Based on the prospective data analysis of nearly 1400 patients, the AARC consensus was published in 2014. Read More

J Gastroenterol 2019 Sep 29;54(9):804-818. Epub 2019 Apr 29.

Department of Gatroenterology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, People's Republic of China.

Background: Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown. Read More

Euroasian J Hepatogastroenterol 2018 Jul-Dec;8(2):148-160. Epub 2019 Feb 1.

Department of Emerging Markets, Dr Reddy's Laboratories Ltd, Hyderabad, Andhra Pradesh, India.

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs), one of the most commonly used medications worldwide, are frequently associated with gastrointestinal adverse events. Primary care physicians often face the challenge of achieving adequate pain relief with NSAIDs, while keeping their adverse events to a minimum. This is especially true when long-term use of NSAIDs is required such as in patients with osteoarthritis and rheumatoid arthritis. Read More

Neuroendocrinology 2019 13;108(4):343-353. Epub 2019 Feb 13.

Department of Hepato-Gastroenterology and Digestive Oncology and Reims-Champagne-Ardennes University, Reims, France.

Introduction: Although chemotherapy combining 5-fluorouracil (5FU)-dacarbazine (DTIC) or temozolomide (TEM)-capecitabine (CAP) is extensively used in patients with neuroendocrine tumors (NET), they were never compared. We compared their tolerance and efficacy in advanced NET.

Methods: We evaluated the records of consecutive patients with pancreatic or small-intestine advanced NET who received 5FU-DTIC or TEM-CAP between July 2004 and December 2017 in 5 French centers. Read More

Eur J Midwifery 2018 16;2:15. Epub 2018 Nov 16.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Introduction: Approximately 25% of all deliveries in Denmark are medically induced, typically characterized by more intense uterine contractions. The aim of this paper is to investigate the differences in the administration of epidural analgesia and pain experience between spontaneous and medically induced labor in nulliparous and multiparous women.

Methods: This is a prospective case-controlled study of 100 participating women in labor. Read More

Kidney Int Rep 2018 Sep 8;3(5):1153-1162. Epub 2018 Jun 8.

Nephrology Department, Rouen University Hospital, Rouen, France.

Introduction: Cobalamin C (cblC) deficiency is the most common inborn error of vitamin B metabolism. Renal failure attributed to thrombotic microangiopathy (TMA) has occasionally been described in the late-onset presentation of cblC deficiency, but kidney lesions associated with cblC deficiency remain poorly defined. This study aims to describe the characteristics of kidney disease in cblC deficiency, and to provide a comparative histological analysis with cblC-independent renal TMA. Read More

Acta Gastroenterol Belg 2018 Jan-Mar;81(1):23-28

Colorectal Surgery Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Background And Study Aims: Data about single-incision laparoscopic surgery (SILS) in locally advanced colorectal cancers are scarce. This study aimed to evaluate perioperative and shortterm oncologic outcomes of SILS in pT3-T4 colorectal cancer.

Patients And Methods: From 2011 to 2015 data from 249 SILS performed in our Colorectal Unit were entered into a prospective database. Read More

Zhonghua Yi Xue Za Zhi 2018 Feb;98(7):527-532

Department of Gatroenterology, Affiliated Zhongshan Hospital, Fudan University, Shanghai 200032, China.

To investigate the effect and mechanism of Kruppel-like factor 2 (KLF2) on the migration of human liver sinusoidal endothelial cells (LSEC). Cultured human LSEC were infected with different lenti-viruses to overexpress or suppress KLF2 expression (LV5-KLF2 and LV3-shKLF2, respectively), the infection efficacies were examined by real-time PCR and Western blot analysis.Transwell migration assay was used to investigate the role of KLF2 on the migration of LSEC. Read More

Am J Physiol Gastrointest Liver Physiol 2018 02 19;314(2):G179-G187. Epub 2017 Oct 19.

Department of Medicine, Salem Medical Center and Center for Alcohol Research and Liver Disease, University of Heidelberg , Heidelberg , Germany.

Liver stiffness (LS) as measured by transient elastography is widely used to screen for liver fibrosis. However, LS also increases in response to pressure changes like congestion but no data on portal pressure are available. We study here the effect of rapid portal pressure changes on LS. Read More

Pediatr Gastroenterol Hepatol Nutr 2017 Mar 27;20(1):55-60. Epub 2017 Mar 27.

Department of Neonatology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.

Intestinal hypoganglionosis is a rare innervation disorder that provides numerous nutritional, medical and surgical challenges. In this case report, we present a case of a newborn with intestinal hypoganglionosis leading to intestinal failure and intestinal failure-associated liver disease who responded to Omegaven™, a fat emulsion comprised of omega-3 fatty acids. Omegaven™ has been shown to be beneficial in the management of cholestatic liver injury. Read More

Int J Surg Case Rep 2017 5;31:214-217. Epub 2017 Jan 5.

Liver Transplantation Unit, Gatroenterology Surgical Centre, College of Medicine, Mansoura University, Egypt.

Introduction: In adult living donor liver transplantation (LDLT), maintenance of adequate portal inflow is essential for the graft regeneration. Portal inflow steal (PFS) may occur due to presence of huge spontaneous porto-systemic collaterals. A surgical procedure to increase the portal inflow is rarely necessary in adult LDLT. Read More

Data Brief 2016 Sep 15;8:925-9. Epub 2016 Jul 15.

Gatroenterology, Hepatology & Nutrition Division, CHU Ste-Justine Research Centre, University of Montreal, Montreal, Canada.

This article provides data and a method related to a research paper entitled "Assessing vitamin D nutritional status: is capillary blood adequate?" (Jensen et al., 2016) [1]. Circulating 25OHD, the accepted biomarker of the vitamin D nutritional status, is routinely measured by automated immunoassays, that although may be performed in hospital central laboratories, often suffer from a lack of specificity with regards to the different vitamin D metabolites, "Measurement of circulating 25-hydroxyvitamin D: a historical review" (Le Goff et al. Read More

Ann Surg 2017 02;265(2):284-290

*Department of Gatroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev Ringvej, Herlev, Denmark †Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Scandinavian Surgical Outcomes Research Group, Sahlgrenska University Hospital, Östra, Gothenburg, Sweden ‡Department of Surgery, Nordsjællands Hospital, Denmark §Department of Surgery, Skaraborgs Sjukhus Skovde, Sweden.

Objective: The objective was to study morbidity and mortality associated with early closure (8-13 days) of a temporary stoma compared with standard procedure (closure after > 12 weeks) after rectal resection for cancer.

Background: A temporary ileostomy may reduce the risk of pelvic sepsis after anastomotic dehiscence. However, the temporary ileostomy is afflicted with complications and requires a second surgical procedure (closure) with its own complications. Read More

Genes Immun 2016 06 21;17(4):261-4. Epub 2016 Apr 21.

Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

The function of the Laccase domain-containing 1 (LACC1) gene is unknown, but genetic variation at this locus has been reported to consistently affect the risk of Crohn's disease (CD) and leprosy. Recently, a LACC1 missense mutation was found in patients suffering from monogenic forms of CD, but also systemic juvenile idiopathic arthritis. We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC). Read More

Clin Chim Acta 2016 Jun 25;457:59-62. Epub 2016 Mar 25.

Gatroenterology, Hepatology & Nutrition Division, CHU Ste-Justine Research Centre, University of Montreal, Canada. Electronic address:

Background: Venous blood is the usual sample for measuring various biomarkers, including 25-hydroxyvitamin D (25OHD). However, it can prove challenging in infants and young children. Hence the finger-prick capillary collection is an alternative, being a relatively simple procedure perceived to be less invasive. Read More

J Am Geriatr Soc 2016 Mar;64(3):683-5

Department of Gatroenterology, Sakura Medical Center, Toho University, Sakura, Japan.