2,714 results match your criteria Gastroschisis


Vomiting as a Presenting Symptom of Infantile Vitamin B12 Deficiency.

Cureus 2022 May 19;14(5):e25134. Epub 2022 May 19.

Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, USA.

An 8-month-old, exclusively breastfed girl presented with a five-month history of vomiting with subsequent failure to thrive and lethargy. Family history was notable for the maternal history of gastroschisis. Mother had no dietary restrictions and had successfully breastfed multiple children for >12 months without issue. Read More

View Article and Full-Text PDF

GASTROSCHISIS FOR THE GASTROENTEROLOGIST: UPDATES ON EPIDEMIOLOGY, MANAGEMENT AND OUTCOMES.

J Pediatr Gastroenterol Nutr 2022 Jun 21. Epub 2022 Jun 21.

Division of Pediatric Gastroenterology, Hepatology and Nutrition Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Conflicts of Interest and Source of Funding: None declared. Gastroschisis is a common congenital abdominal wall defect, likely influenced by environmental factors in utero, with increasing prevalence in the United States. Early detection of gastroschisis in utero has become the standard with improved prenatal care and screening. Read More

View Article and Full-Text PDF

Gastroschisis Due to Maternal Exposure to Carbimazole in A Term Neonate.

Cureus 2022 May 7;14(5):e24808. Epub 2022 May 7.

Neonatal Intensive Care Unit, King Saud Medical City, Riyadh, SAU.

Pregnant women with hyperthyroidism need careful management, which is due to the increased risk of maternal and fetal complications. However, safe and effective therapies for hyperthyroidism during pregnancy remain limited. Carbimazole is an anti-thyroid agent and has been used to treat hyperthyroidism. Read More

View Article and Full-Text PDF

Risk factors for prolonged mechanical ventilation in neonates following gastrointestinal surgery.

Transl Pediatr 2022 May;11(5):617-624

Division of Neonatology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Prolonged mechanical ventilation (MV) should be avoided in neonates. Noninvasive ventilation (NIV) can facilitate weaning from MV but has risks for patients immediately following foregut surgery due to the potential risk of anastomotic leak. We evaluated the risk factors for prolonged MV following intestinal surgery in neonates. Read More

View Article and Full-Text PDF

Coexisting gastrointestinal and hepatobiliary tract anomalies in omphalocele and gastroschisis: A twenty-year experience in a single tertiary medical center.

Pediatr Neonatol 2022 May 18. Epub 2022 May 18.

The Metabolomics Core Laboratory, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: Omphalocele and gastroschisis are the two most common congenital abdominal wall defects; however, no previous study has focused on gastrointestinal and hepatobiliary tract malformations in these two conditions. This study aimed to investigate the demographic characteristics, coexisting congenital gastrointestinal and hepatobiliary tract anomalies, hospital course, and outcomes of patients with gastroschisis and omphalocele.

Methods: This is retrospective chart review of all patients admitted to one tertiary medical center in Taiwan between January 1, 2000 and June 30, 2020 with a diagnosis of gastroschisis or omphalocele. Read More

View Article and Full-Text PDF

Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants-A Bridge Too Far?

Children (Basel) 2022 May 10;9(5). Epub 2022 May 10.

Liver Unit (Including Small Bowel Transplantation), Birmingham Women & Children's Hospital, Birmingham B4 6NH, UK.

Infants with intestinal failure associated liver disease (IFALD) requiring liver and bowel transplant have a high mortality on the transplant waiting list due to the scarcity of the size-matched donor organs. Bridging liver transplantation has been used to allow the children to grow to a reasonable size so that a combined liver and small bowel transplant could be performed in the future. We report on two children with irreversible intestinal failure (ultra-short bowel syndrome secondary to gastroschisis and microvillous inclusion disease) with IFALD who underwent bridging liver transplantation at our institution. Read More

View Article and Full-Text PDF

Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects.

Public Health Nutr 2022 May 27:1-13. Epub 2022 May 27.

Department of Epidemiology, College of Public Health, The University of Iowa, 145 N Riverside Dr, S416 CPHB, Iowa City, IA52242, USA.

Objectives: To explore associations between maternal pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects.

Design: This is a population-based, case-control study using maternal responses to a dietary assessment and published arsenic concentration estimates in food items to calculate average daily total and inorganic arsenic exposure during the year before pregnancy. Assigning tertiles of total and inorganic arsenic exposure, logistic regression analysis was used to estimate OR for middle and high tertiles, compared to the low tertile. Read More

View Article and Full-Text PDF

Dizygotic Twins Concordant for Gastroschisis.

J Obstet Gynaecol Can 2021 Jun 29. Epub 2021 Jun 29.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Dalhousie University, Nova Scotia, Canada.

View Article and Full-Text PDF

Social media communities for patients and families affected by congenital pediatric surgical conditions.

Pediatr Surg Int 2022 Jul 19;38(7):1047-1055. Epub 2022 May 19.

International Center for Colorectal and Urogenital Care, Division of Pediatric Surgery, Anschutz Medical Campus, Children's Hospital Colorado, 13213 E 16th Ave, Box 323, Aurora, CO, 80045, USA.

Background: Social media has become a means to allow individuals affected by rare diseases to connect with others. This study aimed to characterize the use of three popular social media platforms by individuals affected by common pediatric surgery index conditions.

Methods: A systematic search of Instagram, Facebook, and Twitter was performed using standardized terms for the following pediatric surgical conditions: anorectal malformation, biliary atresia, bronchopulmonary sequestration, congenital diaphragmatic hernia (CDH), congenital pulmonary airway malformation, duodenal atresia, esophageal atresia/tracheoesophageal fistula (EA/TEF), gastroschisis, Hirschsprung disease (HD), and omphalocele. Read More

View Article and Full-Text PDF

Umbilical hernia repair post umbilical cord graft closure of gastroschisis: A cohort study.

Int J Surg Case Rep 2022 Jun 11;95:107175. Epub 2022 May 11.

Pediatric Surgery, Cairo University, Egypt.

Introduction: Gastroschisis a common congenital anomaly in the anterior abdominal wall, the bowel is present outside the abdominal cavity, completely devoid of any coverings, management of gastroschisis involves umbilical cord graft coverage of the defect after bowel reduction when there are concerns about compartmental syndrome, this is a widely used technique but there are few reports about the incidence umbilical hernia development after this technique and need for future repair of the defect.

Presentation Of Cases: We had 8 patients with simple gastroschisis who had umbilical cord graft coverage of the defect at birth between 2017 and 2020, we present 4 patients who had the cord graft without cutting of rectus fascia, 2 patients resolved spontaneously and 2 developed an umbilical hernia requiring repair.

Discussion: Umbilical cord graft has been reported in several studies, in those studies the authors reported the spontaneous closure of the defect and some reported that incising the rectus fascia will contribute to development of the umbilical hernia, in our series the rectus fascia was preserved yet 2 patients developed umbilical hernia. Read More

View Article and Full-Text PDF

The complex search for the cause of gastroschisis.

Birth Defects Res 2022 May 16. Epub 2022 May 16.

Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Sao Paulo, Brazil.

Background: To reveal the complex etiology of gastroschisis through two independent cases.

Cases: Case 1 involves gastroschisis recurrence in a consanguineous marriage, and Case 2 concerns a fetus with gastroschisis whose mother had undergone gastroplasty. Methylation array was carried out in both cases (two fetuses with gastroschisis, their two mothers, one father from the consanguineous marriage), and in 16 controls (fetuses and their respective mothers). Read More

View Article and Full-Text PDF

Gestational Age at Delivery and Neonatal Outcomes among Infants with Gastroschisis in the Children's Hospitals Neonatal Consortium (CHNC).

Am J Perinatol 2022 May 12. Epub 2022 May 12.

Seattle Children's Hospital and University of Washington School of Medicine, Seattle, Washington.

Objective:  The effect of gestational age (GA) on gastroschisis outcomes is unclear and delivery timing varies in practice. We aimed to correlate clinical outcomes of infants with gastroschisis and GA at delivery in the Children's Hospitals Neonatal Consortium (CHNC).

Study Design: This was a retrospective multicenter cohort study of infants with gastroschisis admitted to CHNC neonatal intensive care units (NICUs) from 2010 to 2016. Read More

View Article and Full-Text PDF

Hospital Variation in Surgical Technique for Repair of Uncomplicated Gastroschisis.

Am Surg 2022 May 12:31348221101511. Epub 2022 May 12.

Department of Surgery, 8783David Geffen School of Medicine of UCLA, Los Angeles, CA, USA.

Practices in surgical repair of uncomplicated gastroschisis are varied. Data regarding hospital volume, surgical technique, clinical outcomes, and costs remain limited. Neonatal patients with uncomplicated gastroschisis were identified using the 2015-2019 National Readmissions Database. Read More

View Article and Full-Text PDF

Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies.

BMJ Open 2022 05 3;12(5):e048092. Epub 2022 May 3.

Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Objectives: To identify any associations between in utero exposure to five over-the-counter (non-prescription) analgesics (paracetamol, ibuprofen, aspirin, diclofenac, naproxen) and adverse neonatal outcomes.

Design: Retrospective cohort study using the Aberdeen Maternity and Neonatal Databank.

Participants: 151 141 singleton pregnancies between 1985 and 2015. Read More

View Article and Full-Text PDF

Herniated Fallopian Tube in a Female Neonate with Gastroschisis.

Z Geburtshilfe Neonatol 2022 Jun 2;226(3):214. Epub 2022 May 2.

Pediatric Surgery Department, Complejo Hospitalario de Navarra Pamplona, Navarra, Spain.

View Article and Full-Text PDF

Preterm vs term delivery in antenatally diagnosed gastroschisis: a systematic review and meta-analysis.

Am J Obstet Gynecol MFM 2022 07 22;4(4):100651. Epub 2022 Apr 22.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX.

Objective: To review the evidence regarding gestational age at birth, length of stay, sepsis incidence, days on mechanical ventilation, and mortality between preterm and term deliveries in pregnancies complicated by gastroschisis.

Data Sources: We conducted database searches of PubMed, Cochrane Central Register of Controlled Trials, Embase, the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov without language restrictions through August 16, 2021. Read More

View Article and Full-Text PDF

Complex gastroschisis with apple peel jejunoileal atresia, primary closure, and Santulli procedure as a surgical alternative. Case report.

Int J Surg Case Rep 2022 May 19;94:107095. Epub 2022 Apr 19.

Assistant Professor, Universidad del Valle, Cali, Colombia. Electronic address:

Background: Gastroschisis is a closure defect of the abdominal wall classified as complex when it presents with necrosis, volvulus, or atresia of the gastrointestinal tract. Jejunoileal atresia is caused by abnormal closure, discontinuity, or narrowing of the intestine. Apple Peel or type IIIb is the rarest presentation, with an incidence of 1. Read More

View Article and Full-Text PDF

Relationship between volume and outcome for gastroschisis: A systematic review.

J Pediatr Surg 2022 Mar 28. Epub 2022 Mar 28.

Institute for Research in Operative Medicine, Faculty of Health, School of Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, Building 38, 51109, Cologne, Germany; Center for Health Services Research Brandenburg, Brandenburg Medical School Theodor Fontane, Campus Rüdersdorf, Seebad 82/83, 15562, Rüdersdorf, Germany; Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Institute for Health Services and Health System Research, Campus Rüdersdorf, Seebad 82/83, 15562, Rüdersdorf, Germany.

Background: Newborns with gastroschisis need surgery to reduce intestines into the abdominal cavity and to close the abdominal wall. Due to an existing volume-outcome relationship for other high-risk, low-volume procedures, we aimed at examining the relationship between hospital or surgeon volume and outcomes for gastroschisis.

Methods: We conducted a systematic literature search in Medline, Embase, CENTRAL, CINAHL and Biosis Previews in June 2021 and searched for additional literature. Read More

View Article and Full-Text PDF

Evaluating the risk of peri-umbilical hernia after sutured or sutureless gastroschisis closure.

J Pediatr Surg 2022 Mar 26. Epub 2022 Mar 26.

Department of Surgery, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City MO 64108, United States. Electronic address:

Introduction: We evaluate the incidence, outcomes, and management of peri‑umbilical hernias after sutured or sutureless gastroschisis closure.

Methods: A retrospective, longitudinal follow-up of neonates with gastroschisis who underwent closure at 11 children's hospitals from 2013 to 2016 was performed. Patient encounters were reviewed through 2019 to identify the presence of a peri‑umbilical hernia, time to spontaneous closure or repair, and associated complications. Read More

View Article and Full-Text PDF

Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997-2011.

Paediatr Perinat Epidemiol 2022 Apr 18. Epub 2022 Apr 18.

Birth Defects Registry, New York State Department of Health, Albany, New York, USA.

Background: Gastroschisis is particularly prevalent among offspring of young women and has increased over recent decades. Although previous studies suggest that maternal alcohol consumption is associated with increased gastroschisis risk, none have explored whether maternal age modifies that association.

Objective: The objective of the study was to evaluate associations between self-reported maternal periconceptional alcohol consumption (1 month prior through the third month after conception) and risk of gastroschisis among offspring, by maternal age. Read More

View Article and Full-Text PDF

Adherence to the Mediterranean Diet in Pregnancy and Its Benefits on Maternal-Fetal Health: A Systematic Review of the Literature.

Front Nutr 2022 31;9:813942. Epub 2022 Mar 31.

Department of Nursing, University of Alicante, Alicante, Spain.

Introduction: Pregnancy is a transcendent period for the mother and the fetus, characterized by an increase on energy requirements. Mediterranean diet (MD) is considered a healthy eating pattern that can provide the nutritional requirements of pregnancy and protect from the development of obstetric pathologies.

Objective: To know the relationship between adherence to the MD and its maternal-fetal benefits. Read More

View Article and Full-Text PDF

New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology.

Colomb Med (Cali) 2021 Jul-Sep;52(3):e4004227. Epub 2021 Sep 30.

Universidad del Valle, Facultad de Salud, Escuela de Ciencias Básicas, Departamento de Morfología, Cali, Colombia.

gastroschisis is a congenital structural defect of the abdominal wall, most often to the right of the umbilicus, through which the abdominal viscera protrude. Its developmental, etiological and epidemiological aspects have been a hot topic of controversy for a long time. However, recent findings suggest the involving of genetic and chromosomal alterations and the existence of a stress-inducing pathogenetic pathway, in which risk factors such as demographic and environmental ones can converge. Read More

View Article and Full-Text PDF

Avoidance of routine endotracheal intubation and general anesthesia for primary closure of gastroschisis: a systematic review and meta-analysis.

Pediatr Surg Int 2022 Jun 8;38(6):801-815. Epub 2022 Apr 8.

Division of Neonatology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC, Canada.

Purpose: Over the last few decades, several articles have examined the feasibility of attempting primary reduction and closure of gastroschisis without general anesthesia (GA). We aimed to systematically evaluate the impact of forgoing routine intubation and GA during primary bedside reduction and closure of gastroschisis.

Methods: The primary outcome was closure success. Read More

View Article and Full-Text PDF

Nursing Care Plan for a Newborn with the Defect of Congenital Gastroschisis in the Postoperative Period Using ICNP and the Dedicated Software.

Int J Environ Res Public Health 2022 03 16;19(6). Epub 2022 Mar 16.

Department of Coordinated Care, Medical University of Lodz, Kościuszki Street 4, 90-131 Lodz, Poland.

Background: Congenital defect gastroschisis manifests as a defect in the sheath in the intestine of the newborn, which is not covered by the hernia sac. In this case, the priority task of the neonatal nurse is to diagnose patient care problems quickly and accurately. Choosing the correct care plan elements has a significant impact on shortening the duration of hospitalization, reducing the number and severity of complications, and preventing their recurrence. Read More

View Article and Full-Text PDF

Fetal Surgery for Gastroschisis-A Review with Emphasis on Minimally Invasive Procedures.

Children (Basel) 2022 Mar 15;9(3). Epub 2022 Mar 15.

Department of General, Visceral, Thoracic, Transplant and Pediatric Surgery, University Medical Center Schleswig-Holstein (UKSH), Kiel Campus, Arnold-Heller-Strasse 3, 24105 Kiel, Germany.

(1) Background: The morbidity of gastroschisis is defined by exposure of unprotected intestines to the amniotic fluid leading to inflammatory damage and consecutive intestinal dysmotility, the viscero-abdominal disproportion which results in an abdomen too small to incorporate the herniated and often swollen intestine, and by associated pathologies, such as in complex gastroschisis. To prevent intestinal damage and to provide for growth of the abdominal cavity, fetal interventions such as amnio exchange, gastroschisis repair or covering have been evaluated in several animal models and human trials. This review aims to evaluate the reported techniques for the fetal treatment of gastroschisis by focusing on minimally invasive procedures. Read More

View Article and Full-Text PDF

Gastroschisis prognostic score successfully identifies brazilian newborns with high-risk gastroschisis.

J Pediatr Surg 2022 Feb 24. Epub 2022 Feb 24.

Serviço de Cirurgia Pediátrica, Hospital das Clínicas da Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte, MG, Brazil, 30130-100; Departamento de Cirurgia, Faculdade de Medicina da Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190 - Santa Efigênia, Belo Horizonte, MG, Brazil, 30130-100. Electronic address:

Background: The Gastroschisis Prognostic Score (GPS) stratifies patients as high or low risk based on the visual assessment of intestinal matting, atresia, perforation, or necrosis. Despite being a simple score, its applicability to low and middle-income countries (LMICs) remains unknown. We tested the hypothesis that GPS can predict outcomes in LMICs, by assessing the prognostic value of the GPS in a middle-income country. Read More

View Article and Full-Text PDF
February 2022

Gestational Age-Dependent Reference Ranges for Albumin Levels in Cord Serum.

Neonatology 2022 16;119(3):327-333. Epub 2022 Mar 16.

Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, Japan.

Background: To diagnose hypoalbuminemia in newborns, it is essential to establish a definition applicable to those with a different gestational age (GA) and clinical conditions. A positive correlation between serum albumin levels and GA has been reported, but the study was limited to small numbers of newborns. We therefore investigated the GA-dependent reference ranges for serum albumin levels using cord venous blood (UC-Alb levels) from a large number of newborns delivered at a tertiary perinatal center. Read More

View Article and Full-Text PDF

Trends in prevalence and mortality of gastroschisis and omphalocele in the United States from 2010 to 2018.

World J Pediatr 2022 Jul 16;18(7):511-514. Epub 2022 Mar 16.

Neonatal Intensive Care Unit, Valley Children's Hospital, 9300 Valley Children's Place, SE 20, Madera, CA, 93636, USA.

View Article and Full-Text PDF

Patterns of multiple congenital anomalies in the National Birth Defect Prevention Study: Challenges and insights.

Birth Defects Res 2022 Mar 11. Epub 2022 Mar 11.

Birth Defects Registry, New York State Department of Health, Albany, New York, USA.

Background: About 20%-30% of children with birth defects have multiple major birth defects in more than one organ system, often referred to as multiple congenital anomalies (MCAs). Evaluating the patterns of MCAs can provide clues to the underlying causes, pathogenic mechanisms, and developmental pathways. We sought to explore selected patterns of MCAs within the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study that excluded cases attributed to known chromosomal or single-gene abnormalities. Read More

View Article and Full-Text PDF

Rare Presentation of Limb-Body Wall Complex in a Neonate: Case Report and Review of Literature.

AJP Rep 2022 Jan 7;12(1):e108-e112. Epub 2022 Mar 7.

Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennessee.

The limb-body wall complex (LBWC) aka body stalk syndrome is an uncommon congenital disorder characterized by severe malformations of limb, thorax, and abdomen, characterized by the presence of thoracoschisis, abdominoschisis, limb defects, and exencephaly. This condition is extremely rare with an incidence of 1 per 14,000 and 1 per 31,000 pregnancies in large epidemiologic studies. Majority of these malformed fetuses end up with spontaneous abortions. Read More

View Article and Full-Text PDF
January 2022