400,647 results match your criteria Gastrointestinal Stromal Tumors – Leiomyoma Leiomyosarcoma


Laparoscopic excision of a cystic vascular malformation of the sigmoid colon mesentery presenting as a retroperitoneal tumour - a video vignette.

Colorectal Dis 2020 Jul 3. Epub 2020 Jul 3.

Klaipeda University Hospital, Klaipeda, Lithuania.

Mesenteric tumours are quite rare and form a heterogeneous group of tumours. Most of the time they are found accidently on computed tomography (CT) causing only vague abdominal symptoms. These tumours can arise from any of the mesenteric components: vessels, peritoneum, lymphatic tissue, fat, and connective tissue [1]. Read More

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http://dx.doi.org/10.1111/codi.15230DOI Listing

Red beet (Beta vulgaris) and amaranth (Amaranthus sp.) microgreens: Effect of storage and in vitro gastrointestinal digestion on the untargeted metabolomic profile.

Food Chem 2020 Jun 27;332:127415. Epub 2020 Jun 27.

Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey.

This study aimed to investigate the combined effect of storage at 4 °C (10-days) and in vitro gastrointestinal digestion on the phytochemical profile of red beet (Beta vulgaris) and amaranth (Amaranthus sp.) microgreens. The untargeted profiling based on UHPLC-QTOF metabolomics allowed annotating 316 compounds, comprising mainly polyphenols and lipids. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127415DOI Listing

Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.

Cancer Treat Res Commun 2020 Jun 27;24:100187. Epub 2020 Jun 27.

Department of Oncology, Rigshospitalet, Copenhagen, Denmark.

Background: Chemoradiotherapy is standard treatment for localized oesophageal cancer unsuitable for surgery. We aimed to evaluate the efficacy of cetuximab in combination with chemoradiotherapy.

Methods: This non-randomised multicentre phase II trial recruited patients aged 18-75 with WHO performance status 0-2 having squamous cell carcinoma or adenocarcinoma in the oesophagus or gastro-oesophageal junction, T2-4, N0-3, M0 not suitable for surgery. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100187DOI Listing

Prognostic indicators for gastrointestinal stromal tumors: a review.

Authors:
Haixin Zhang Qi Liu

Transl Oncol 2020 Jun 26;13(10):100812. Epub 2020 Jun 26.

Department of Trauma center, The First Hospital of China Medical University, Shenyang, China. Electronic address:

Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main prognostic factors are the mitotic rate, tumor size and tumor site. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100812DOI Listing

UPLC-MS/MS-based molecular networking and NMR structural determination for the untargeted phytochemical characterization of the fruit of Crescentia cujete (Bignoniaceae).

Phytochemistry 2020 Jun 30;177:112438. Epub 2020 Jun 30.

Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

The fruit pulp of Crescentia cujete is traditionally used in folk medicine for the treatment of a variety of respiratory conditions and gastrointestinal disorders. Due to the lack of a comprehensive phytochemical description of the fruit of this plant, its active compounds and rational quality control parameters have not yet been described. An untargeted metabolomics approach combining UPLC-MS/MS-based molecular networking with conventional isolation and NMR methods was carried out for the phytochemical profiling of the fruit pulp of Crescentia cujete. Read More

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http://dx.doi.org/10.1016/j.phytochem.2020.112438DOI Listing

Analyzing Risk Factors for Enterostomy Infection and Neuropsychology of Patients by Computer Information Data Regression under Endoscopic Image Guidance.

Neurosci Lett 2020 Jun 30:135223. Epub 2020 Jun 30.

Gastrointestinal Surgery, Chongqing University Cancer Hospital, No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China. Electronic address:

This study was aimed to investigate the possible risk factors of stoma prolapsing infection and neuropsychological problems after colostomy based on the artificial intelligence DiracNet network. 380 patients who underwent colostomy were selected as the research objects. The clinical data of these patients were analyzed, and postoperative follow-ups were performed. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135223DOI Listing

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.

Lancet Gastroenterol Hepatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Background: The LIR!C trial showed that laparoscopic ileocaecal resection is a cost-effective treatment that has similar quality-of-life outcomes to treatment with infliximab, an anti-tumour necrosis factor (TNF) drug. We aimed to compare long-term outcomes of both interventions and identify baseline factors associated with the duration of treatment effect in each group.

Methods: In this retrospective follow-up study, we collected data from patients who participated in the LIR!C trial, a multicentre randomised controlled trial that compared quality of life after surgical resection versus infliximab in adult patients with non-stricturing and immunomodulator-refractory ileocaecal Crohn's disease. Read More

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http://dx.doi.org/10.1016/S2468-1253(20)30117-5DOI Listing

Dual role of sirtuin 1 in inflammatory bowel disease.

Immunopharmacol Immunotoxicol 2020 Jul 3:1-22. Epub 2020 Jul 3.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India, 147002.

Silent information regulator-1 (SIRT-1), is a member of the class III group of histone deacetylases and is collectively called sirtuins. There have been preclinical and clinical studies indicating the downregulation and decreased activity of sirtuin 1 in various inflammatory bowel disease models. Furthermore, the downregulation of sirtuin 1 is responsible for the sustained production of proinflammatory cytokines and the generation of oxidative stress in colitis. Read More

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http://dx.doi.org/10.1080/08923973.2020.1790595DOI Listing

Direct access endoscopy in a Brazilian public healthcare facility: comparable results with specialist referred endoscopy.

Scand J Gastroenterol 2020 Jul 3:1-6. Epub 2020 Jul 3.

Division of Gastroenterology (Gastrocentro), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Direct access endoscopy (DAE) is the procedure performed without the pre-evaluation of the patient by a specialist. It is widely available in many medical services around the world, but there is lack of data about this strategy in the setting of the public health system in Brazil. Therefore, the aim of this study is to compare the main endoscopic findings of upper gastrointestinal endoscopy requested through DAE and by specialists. Read More

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http://dx.doi.org/10.1080/00365521.2020.1787500DOI Listing

Impact of DPYD, DPYS and UPB1 gene variations on severe drug-related toxicity in cancer patients.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Cancer treatment with a fluoropyrimidine (FP) is often accompanied by severe toxicity that may be dependent on the activity of catalytic enzymes encoded by the DPYD, DPYS and UPB1 genes. Genotype-guided dose individualization of FP therapy has been proposed in Western countries, but our knowledge of the relevant genetic variants in East Asian populations is presently limited. To investigate the association between these genetic variations and FP-related high toxicity in a Japanese population, we obtained blood samples from 301 patients who received this chemotherapy and sequenced the coding exons and flanking intronic regions of their DPYD, DPYS and UPB1 genes. Read More

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http://dx.doi.org/10.1111/cas.14553DOI Listing

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

J Pathol 2020 Jul 3. Epub 2020 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, US.

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with squamous cell carcinomas display hyperactive NRF2 signaling, harboring activating mutations and copy number amplifications of the NFE2L2 oncogene or inactivating mutations or deletions of KEAP1 or CUL3, the proteins of which co-complex to ubiquitylate and degrade NRF2 protein. Read More

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http://dx.doi.org/10.1002/path.5504DOI Listing

Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.

Inflamm Bowel Dis 2020 Jul 3. Epub 2020 Jul 3.

Institute for Health and Sport, Victoria University; Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, Victoria, Australia.

Background: Inflammatory bowel disease (IBD) associates with damage to the enteric nervous system (ENS), leading to gastrointestinal (GI) dysfunction. Oxidative stress is important for the pathophysiology of inflammation-induced enteric neuropathy and GI dysfunction. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a dual functioning protein that is an essential regulator of the cellular response to oxidative stress. Read More

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http://dx.doi.org/10.1093/ibd/izaa161DOI Listing

Duration of Respiratory and Gastrointestinal Viral Shedding in Children With SARS-CoV-2: A Systematic Review and Synthesis of Data.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Infectious Diseases, Austin Hospital, Heidelberg.

Background: Children with coronavirus disease 2019 (COVID-19) are more likely to have mild or no symptoms compared to adults and may represent important vectors for transmitting the virus. Little is known about the duration of respiratory and gastrointestinal viral shedding in children with COVID-19.

Objective: To determine the average shedding times of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via the respiratory and gastrointestinal tracts in children. Read More

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http://dx.doi.org/10.1097/INF.0000000000002814DOI Listing

Association of Digestive Symptoms and Hospitalization in Patients With SARS-CoV-2 Infection.

Am J Gastroenterol 2020 Jul;115(7):1129-1132

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Redwood City, California, USA.

Introduction: High rates of concurrent gastrointestinal manifestations have been noted in patients with corona virus disease 2019 (COVID-19); however, the association between these digestive manifestations and need for hospitalization has not been established.

Methods: This is a retrospective review of consecutive patients diagnosed with COVID-19. A total of 207 patients were identified; 34. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000712DOI Listing

Opioids Interfere With Deglutitive Inhibition Assessed by Response to Multiple Rapid Swallows During High-Resolution Esophageal Manometry.

Am J Gastroenterol 2020 Jul;115(7):1125-1128

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona.

Introduction: Normal response to multiple rapid swallows (MRS) during high-resolution esophageal manometry is deglutitive inhibition; opioids may interfere with this. The aim of this study was to evaluate the response to MRS in patients on opioids, not on opioids, and healthy controls.

Methods: Response to MRS was evaluated for complete vs impaired inhibition in 72 chronic opioid users, 100 patients not on opioids, and 24 healthy controls. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000682DOI Listing

Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century.

Am J Gastroenterol 2020 Jul;115(7):1117-1124

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Introduction: We assessed whether celiac disease-associated mortality is increased in Finland among patients diagnosed in the 21st century, given recent improvements in diagnostic and treatment facilities.

Methods: Biopsy-proven patients with celiac disease (Marsh III) and dermatitis herpetiformis aged 20-79 years (median 50 years) diagnosed 2005-2014 (n = 12,803) were identified from the national dietary grant registry. Dates and causes of death were obtained from Statistics Finland. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000665DOI Listing

COVID-19 and the Digestive System.

Am J Gastroenterol 2020 Jul;115(7):1003-1006

Department of Gastroenterology, West China Hospital and State Key Lab of Biotherapy, Sichuan University, Chengdu, China.

The outbreak of novel coronavirus pneumonia in 2019 (Coronavirus disease 2019 [COVID-19]) is now threatening global public health. Although COVID-19 is principally defined by its respiratory symptoms, it is now clear that the virus can also affect the digestive system. In this review, we elaborate on the close relationship between COVID-19 and the digestive system, focusing on both the clinical findings and potential underlying mechanisms of COVID-19 gastrointestinal pathogenesis. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000691DOI Listing

Hemolysin BL from novel BV-17 induces antitumor activity both in vitro and in vivo.

Gut Microbes 2020 Jul 3:1-15. Epub 2020 Jul 3.

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute , Beijing, China.

The gut microbiota plays an important role in cancer development and immunotherapy. Bacterial toxins have enormous antitumor potential due to their cytotoxicity and ability to activate the immune system. Using 16S rRNA gene sequencing, we compared the gut microbiota composition of fecal samples from healthy individuals and patients with colorectal cancer (CRC) and observed that the was common in the healthy donors but was absent in the CRC patients. Read More

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http://dx.doi.org/10.1080/19490976.2020.1782158DOI Listing

Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis.

J Vet Intern Med 2020 Jul 3. Epub 2020 Jul 3.

Department of Veterinary Science, University of Turin, Grugliasco, Italy.

Background: Chronic idiopathic lymphoplasmacytic rhinitis (CILPR) is a common inflammatory disorder of unknown etiology affecting the nasal cavity of dogs. The diagnosis is made by exclusion of other causes of nasal disease and specific therapeutic protocols are lacking. In human medicine, a relationship between CILPR and gastrointestinal clinical signs has been postulated, and remission of respiratory signs after clinical trials with medications for gastrointestinal disorders has been observed. Read More

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http://dx.doi.org/10.1111/jvim.15827DOI Listing

A theoretic approach to the mode of gut microbiome translocation in SIV-infected Asian macaques.

FEMS Microbiol Ecol 2020 Jul 3. Epub 2020 Jul 3.

Computational Biology and Medical Ecology Lab, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, China.

Human gut microbiome could translocate to other tissues, and the relocation triggered by HIV/SIV infection has received increasing attention. However, the underlying mode of this translocation, whether it is deterministic or random (passive) process, is not clear, not to mention quantitative estimation of the relocation probability and rates. Using multi-tissue microbiome datasets collected from SIV-infected macaques, originally reported by Klase et al. Read More

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http://dx.doi.org/10.1093/femsec/fiaa134DOI Listing

Real-world management of oral factor Xa inhibitor-related bleeds with reversal or replacement agents including andexanet alfa and four-factor prothrombin complex concentrate: a multicenter study.

Future Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Portola Pharmaceuticals Inc. 270 E. Grand Avenue South San Francisco, CA 94080, USA.

We describe the real-world utilization and outcomes associated with managing oral factor Xa inhibitor (FXai)-related major bleeds. Electronic records from 45 US hospitals were queried (ICD-10-CM billing codes D68.32, T45. Read More

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http://dx.doi.org/10.2217/fca-2020-0073DOI Listing

Intra-gastrointestinal amyloid-β1-42 oligomers perturb enteric function and induce Alzheimer's disease pathology.

J Physiol 2020 Jul 2. Epub 2020 Jul 2.

School of Biomedical Sciences.

Key Points: Alzheimer's disease (AD) patients and transgenic mice have beta-amyloid (Aβ) aggregation in the gastrointestinal (GI) tract. It is possible that Aβ from the periphery contributes to the load of Aβ in the brain, as Aβ has prion-like properties. The present investigations demonstrate that Aβ injected into the GI tract of ICR mice is internalised into enteric cholinergic neurons; at 1 month, administration of Aβ into the body of the stomach and the proximal colon was observed to partly redistribute to the fundus and jejunum; at 1 year, vagal and cerebral β-amyloidosis was present, and mice exhibited GI dysfunction and cognitive deficits. Read More

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http://dx.doi.org/10.1113/JP279919DOI Listing

Modeling the effect of DAV132, a novel colon-targeted adsorbent, on fecal concentrations of moxifloxacin and gut microbiota diversity in healthy volunteers.

Clin Pharmacol Ther 2020 Jul 2. Epub 2020 Jul 2.

Universite de Paris, IAME, INSERM, F-75018, Paris, France.

To prevent antibiotic-induced perturbations on gut microbiota, DAV132, a novel colon-targeted adsorbent, which sequesters antibiotic residues in the lower gastrointestinal tract was developed. We built an integrated pharmacological model of how DAV132 reduces fecal free moxifloxacin (MXF) and preserves gut microbiota. We used plasma and fecal free MXF concentrations, and Shannon diversity index from 16S rRNA gene metagenomics analysis of fecal microbiota, of 143 healthy volunteers assigned randomly to receive MXF only, or with ten DAV132 dose regimens, or to a control group. Read More

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http://dx.doi.org/10.1002/cpt.1977DOI Listing

Improving Access to Bariatric Surgery for Rural and Remote Patients: Experiences from a State-Wide Bariatric Telehealth Service in Australia.

Obes Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Upper Gastrointestinal and Bariatric Surgery, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Background: The state of Queensland, Australia, is large (1.85 million km). The provision of bariatric care across the state is difficult as most major hospitals are concentrated in the capital city of Brisbane. Read More

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http://dx.doi.org/10.1007/s11695-020-04804-wDOI Listing

The effect of teprenone on the intestinal morphology and microbial community of Chinese sea bass (Lateolabrax maculatus) under intermittent hypoxic stress.

Fish Physiol Biochem 2020 Jul 2. Epub 2020 Jul 2.

Fisheries Engineering Institute, Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, No. 231 West Xingang Road, Haizhu District, Guangzhou, 510300, China.

Hypoxia stress may affect the fish intestine and thereby threaten the growth and survival of the fish. Teprenone is a clinically effective agent in protecting gastrointestinal mucosa. This study aims to assess the effect of teprenone in the intestine of Chinese sea bass Lateolabrax maculatus under intermittent hypoxic stress. Read More

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http://dx.doi.org/10.1007/s10695-020-00838-0DOI Listing

Impacts of low salinity exposure and antibiotic application on gut transport activity in the Pacific spiny dogfish, Squalus acanthias suckleyi.

J Comp Physiol B 2020 Jul 2. Epub 2020 Jul 2.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.

The role of the marine elasmobranch gastrointestinal tract in nitrogen-recycling and osmotic homeostasis has become increasingly apparent, with the gut microbial community likely playing a significant role converting urea, an important osmolyte in elasmobranchs, into ammonia. The Pacific spiny dogfish can experience and tolerate reduced environmental salinities, yet how this environmental challenge may affect the microbiome, and consequently nitrogen transport across the gut, is as of yet unknown. In the present study, excised gut sac preparations were made from dogfish acclimated to the following: full-strength seawater (C), low salinity for 7 days (LS), and after acute transfer of LS-acclimated fish to full-strength SW for 6 h (AT). Read More

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http://dx.doi.org/10.1007/s00360-020-01291-4DOI Listing

Clinical characteristics and comparison of the outcome in young versus older patients with upper gastrointestinal carcinoma.

J Cancer Res Clin Oncol 2020 Jul 2. Epub 2020 Jul 2.

Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: The clinical behaviour and outcome of young patients with gastroesophageal tumours (GET) is surmised to differ from older patients, yet data on the comparison of these two patient subgroups is scarce. This study focuses on the investigation of the clinical characteristics and survival outcome of younger-age people with GET, when compared to older patients.

Methods: Patients diagnosed with GET at the Medical University of Vienna between 2004 and 2016 were included in this study. Read More

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http://dx.doi.org/10.1007/s00432-020-03302-xDOI Listing

Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: long-term results of KDOG1001 trial.

Langenbecks Arch Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, Kitasato 1-15-1, Minami-ku, Sagamihara, 252-0374, Japan.

Purpose: The purpose of this study is to evaluate the long-term survival outcomes of KDOG1001 trial after a minimum follow-up of 3 years.

Methods: Patients with bulky N2 lymph nodes, linitis plastica (type 4), or large ulcero-invasive-type tumors (type 3) received up to four 28-day cycles of DCS neoadjuvant chemotherapy (docetaxel at 40 mg/m, cisplatin at 60 mg/m on day 1, and S-1 at 40 mg/m twice daily for 2 weeks) followed by gastrectomy with D2 lymphadenectomy plus adjuvant S-1 therapy for 1 year. The final preplanned analysis of long-term outcomes including overall survival and relapse-free survival was conducted after minimum follow-up of 3 years. Read More

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http://dx.doi.org/10.1007/s00423-020-01924-wDOI Listing

Gastrointestinal involvement in adult immunoglobulin A vasculitis and its management. Comment on Gastrointestinal involvement in adult IgA vasculitis (Henoch-Schönlein purpura): updated picture from a French multicentre and retrospective series of 260 cases.

Rheumatology (Oxford) 2020 Jul 2. Epub 2020 Jul 2.

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1093/rheumatology/keaa278DOI Listing

A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design.

Contemp Clin Trials Commun 2020 Jun 4;18:100573. Epub 2020 May 4.

Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.

Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease >4. Read More

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http://dx.doi.org/10.1016/j.conctc.2020.100573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322804PMC

Covid-19 pandemic impact on colonoscopy service and suggestions for managing recovery.

Endosc Int Open 2020 Jul 24;8(7):E985-E989. Epub 2020 Jun 24.

Veteran Affairs Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center, California, United States.

 As the post-peak phase of the epidemic is approaching, there is an urgent need of an action plan to help resume endoscopy activity. To manage the Covid-19 pandemic-imposed backlog of postponed colonoscopy examinations, an efficient approach is needed. The practice of on-demand sedation with benzodiazepines and/or opiates will allow most patients to complete a water-aided examination with minimal or no sedation. Read More

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http://dx.doi.org/10.1055/a-1196-1711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314656PMC

Impact of COVID-19 on gastrointestinal endoscopy practice in India: a cross-sectional study.

Endosc Int Open 2020 Jul 18;8(7):E974-E979. Epub 2020 Jun 18.

Asian Institute of Gastroenterology - Gastroenterology, Telangana, India.

Gastrointestinal endoscopy, being an aerosol-generating procedure, has the potential to transmit Severe Acute Respiratory Distress Syndrome Corona Virus-2 (SARS-CoV-2) during the current pandemic. Adequate knowledge is the key to prevention. A survey, perhaps the first, was conducted among Indian endoscopists to assess the impact of Coronavirus Disease (COVID)-19 on gastroinestinal endoscopy practice in the country. Read More

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http://dx.doi.org/10.1055/a-1181-8391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302931PMC

Urgent endoscopy in children: epidemiology in a large region of France.

Endosc Int Open 2020 Jul 16;8(7):E969-E973. Epub 2020 Jun 16.

Pediatric Gastroenterology and Nutrition, Universitary Robert-Debré hospital, Paris, France.

The real burden of urgent endoscopy in children has not been studied yet. Our aim was to evaluate the need for urgent endoscopy in children. Information was collected about all the calls that were received during the 24 hour on-call shift for pediatric endoscopy in the region of Ile-de-France (12. Read More

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http://dx.doi.org/10.1055/a-1178-9408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297613PMC

Peroral endoscopic pyloromyotomy for gastroparesis: a systematic review and meta-analysis.

Endosc Int Open 2020 Jul 16;8(7):E911-E923. Epub 2020 Jun 16.

Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Gastric peroral endoscopic pyloromyotomy (G-POEM) is a new therapeutic option for refractory gastroparesis (GP). A systematic review and meta-analysis was conducted to assess the effectiveness of G-POEM in refractory GP. For the quality of evidence, we used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Read More

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http://dx.doi.org/10.1055/a-1119-6616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297609PMC

Outcomes of biliopancreatic EUS in patients with surgically altered upper gastrointestinal anatomy: a multicenter study.

Endosc Int Open 2020 Jul 16;8(7):E869-E876. Epub 2020 Jun 16.

Gastroenterology and Digestive Endoscopy Unit, The Pancreas Institute, G.B. Rossi University Hospital, Verona, Italy.

Little is known about outcomes of biliopancreatic endosonography (EUS) in patients with surgically altered upper gastrointestinal (gastrointestinal) anatomy. We aimed to assess the rate of procedural success and EUS-related adverse events (AEs), according to post-surgical anatomies. Retrospective study including patients with post-surgical altered upper gastrointestinal anatomy who underwent EUS for evaluation of the biliopancreatic region between January 2008 and June 2018 at eight European centers. Read More

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http://dx.doi.org/10.1055/a-1161-8713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297615PMC

A Ligamentous Agony: Median Arcuate Ligament Syndrome as an Under-Recognized Cause of Abdominal Pain.

Cureus 2020 Jun 27;12(6):e8865. Epub 2020 Jun 27.

Internal Medicine, Rochester General Hospital, Rochester, USA.

Median arcuate ligament (MAL) syndrome (MALS) is a rare clinical entity characterized by chronic abdominal pain resulting from compression of the celiac artery by the MAL. We present a case of MALS with imaging evidence of anterior compression of the celiac artery on expiration, which was relieved on inspiration. A 33-year-old woman presented with intermittent upper abdominal pain since three months. Read More

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http://dx.doi.org/10.7759/cureus.8865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325387PMC

The Role of Immune Checkpoint Inhibitors in the Treatment of Extensive-Stage Extrapulmonary Small Cell Carcinoma.

Cureus 2020 Jun 27;12(6):e8862. Epub 2020 Jun 27.

Hematology and Medical Oncology, Geisinger Medical Center, Danville, USA.

Small cell carcinoma is a type of highly aggressive poorly differentiated neuroendocrine tumor that can arise from multiple organs, including but not limited to bronchial tissue, pancreas, gastrointestinal tract, and genitourinary system. The most commonly studied type is small cell lung cancer (SCLC) which carries the worst prognosis among lung cancers. After multiple promising clinical trials, the National Comprehensive Cancer Network has recently added atezolizumab and durvalumab in combination with platinum-based chemotherapy/etoposide to the first-line treatment regimen for extensive-stage SCLC (ES-SCLC). Read More

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http://dx.doi.org/10.7759/cureus.8862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325398PMC

Rectal Lipoma in an Elderly Male: A Case Report.

Cureus 2020 May 30;12(5):e8366. Epub 2020 May 30.

First Department of Surgery, Saint George General Hospital of Chania, Chania, GRC.

Lipomas of the gastrointestinal tract are uncommon, benign non-epithelial tumors detected incidentally during surgery or endoscopy. Rectal lipomas are extremely rare. Patients may be asymptomatic or present with rectal bleeding, constipation, tenesmus and signs of intestinal obstruction. Read More

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http://dx.doi.org/10.7759/cureus.8366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325349PMC

A Tale of Three Dieulafoy Lesions: A Case Report and Review of the Literature.

Cureus 2020 May 30;12(5):e8365. Epub 2020 May 30.

Gastroenterology and Hepatology, Guthrie Clinic, Robert Packer Hospital, Sayre, USA.

A Dieulafoy lesion (DL) is a rare cause of non-variceal upper gastrointestinal hemorrhage. It is a large submucosal artery that lies in close proximity to the mucosal surface without any evidence overlying superficial ulcers. DLs can be found anywhere within the gastrointestinal (GI) tract, but are frequently encountered within the stomach. Read More

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http://dx.doi.org/10.7759/cureus.8365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325347PMC

Skipping the Drip: Intravenous Proton Pump Inhibitor Bolus Therapy Leads to Poor Outcomes in High-Risk Bleeding.

Cureus 2020 May 30;12(5):e8362. Epub 2020 May 30.

Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, USA.

Background and Aim The aim of this study was to evaluate the impact of a change in our institute's protocol from continuous intravenous (IV) proton pump inhibitor (PPI) therapy to bolus IV PPI therapy for the treatment of peptic ulcer-related bleeding on patient outcomes. Current guidelines recommend PPI therapy through high-dose IV bolus followed by continuous infusion for bleeding ulcers. Conflicting data have been reported regarding the practice shift to intermittent IV PPI therapy. Read More

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http://dx.doi.org/10.7759/cureus.8362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325381PMC

Medical Management of Crohn's Disease.

Cureus 2020 May 29;12(5):e8351. Epub 2020 May 29.

Medical Education Internal Medicine, Brookwood Baptist Medical Center, Birmingham, USA.

Crohn's disease (CD) is a chronic inflammatory bowel disease that can affect the entire gastrointestinal tract from the mouth to the anus, sparing the rectum. The goal of medical therapy is to induce remission with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important, as there is an overlap of medications used to induce and maintain remission. Read More

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http://dx.doi.org/10.7759/cureus.8351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325380PMC

Primary Gastrointestinal Stromal Tumor Presenting as an Isolated Lung Mass.

Cureus 2020 May 28;12(5):e8343. Epub 2020 May 28.

Internal Medicine, Methodist Health System, Dallas, USA.

Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal (GI) tumors, representing a small portion of soft tissue tumors of the abdominal cavity. Extraintestinal gastrointestinal stromal tumors (EGISTs) are uncommon forms of GISTs that present outside the GI tract. There have only been a rare number of reported cases of EGIST presenting above the diaphragm. Read More

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http://dx.doi.org/10.7759/cureus.8343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325361PMC

Jaundice and Elevated Beta-Human Chorionic Gonadotropin in a Female: Duodenal Choriocarcinoma, Not Pregnancy.

Cureus 2020 May 28;12(5):e8336. Epub 2020 May 28.

Gastroenterology, Larkin Community Hospital, South Miami, USA.

A 29-year-old woman with developmental delay presented with 2.5 weeks of jaundice of the skin with accompanying microcytic anemia (hemoglobin 6.8 g/dL, mean corpuscular volume 70. Read More

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http://dx.doi.org/10.7759/cureus.8336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325344PMC

Angiography versus colonoscopy in patients with severe lower gastrointestinal bleeding: a nation-wide observational study.

Acute Med Surg 2020 Jan-Dec;7(1):e533. Epub 2020 Jun 30.

Department of Clinical Epidemiology and Health Economics School of Public Health The University of Tokyo Tokyo Japan.

Aim: Clinical guidelines for acute lower gastrointestinal bleeding (LGIB) recommend non-endoscopic treatment when endoscopic treatment is difficult or the patient is hemodynamically unstable. The aim of this study was to investigate whether angiography should be prioritized as initial treatment for severe LGIB patients over colonoscopy.

Methods: We undertook a retrospective cohort study using the Japanese Diagnosis Procedure Combination inpatient database. Read More

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http://dx.doi.org/10.1002/ams2.533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326725PMC

Soporific Effect of Modified Suanzaoren Decoction and Its Effects on the Expression of CCK-8 and Orexin-A.

Evid Based Complement Alternat Med 2020 16;2020:6984087. Epub 2020 Jun 16.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, No. 18, Chaowang Road, Xiacheng District, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.

Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as a treatment for insomnia for more than a thousand years. However, recent studies have found no significant effects of SZRT as a treatment for insomnia caused by gastric discomfort. Herein, we studied the effects of modified Suanzaoren decoction (MSZRD) on gastrointestinal disorder-related insomnia. Read More

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http://dx.doi.org/10.1155/2020/6984087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315314PMC

Systematic profiling of alternative splicing in -negative gastric cancer and their clinical significance.

Cancer Cell Int 2020 30;20:279. Epub 2020 Jun 30.

Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001 Liaoning China.

Background: Alternative splicing (AS) may cause structural and functional variations in the protein to promote the proliferation of tumor cells. However, there is no comprehensive analysis of the clinical significance of AS in -negative gastric cancer (HP GC).

Methods: The clinical, gene expression profile data and AS events of 138 HP GC patients were obtained from the database named the cancer genome atlas. Read More

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http://dx.doi.org/10.1186/s12935-020-01368-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325377PMC

Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review.

Mediators Inflamm 2020 12;2020:9706140. Epub 2020 Jun 12.

College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract resulting from the homeostasis imbalance of intestinal microenvironment, immune dysfunction, environmental and genetic factors, and so on. This disease is associated with multiple immune cells including regulatory T cells (Tregs). Tregs are a subset of T cells regulating the function of various immune cells to induce immune tolerance and maintain intestinal immune homeostasis. Read More

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http://dx.doi.org/10.1155/2020/9706140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306093PMC

How should be the Surgical Treatment Approach during the COVID-19 Pandemic in Patients with Gastrointestinal Cancer?

Sisli Etfal Hastan Tip Bul 2020 16;54(2):136-141. Epub 2020 Jun 16.

Department of General Surgery, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

COVID-19 was first seen in China at the end of December 2019. COVID-19 is a novel type of coronavirus that is defined as SARS-CoV-2, which can be mild or severe in the lungs, causing acute respiratory infection. The disease was first presented in the literature as Coronavirus Disease 2019 (COVID-19) in February 2020. Read More

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http://dx.doi.org/10.14744/SEMB.2020.93709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326676PMC