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Sr Care Pharm 2022 Jul;37(7):266-283

Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico.

To determine the prevalence and features of self-medication (SM) in Mexican populations. An electronic bibliographic search was carried out from databases and indexing services including Scopus, PubMed, International Pharmaceutical Abstracts (Clarivate Analytics), Embase, Web of Science and Google Scholar addressing SM practice in Mexican populations, SM with allopathic or conventional medicines (CM) or complementary and alternative medicine (CAM), and features of SM (diseases-related, factors-associated, and drugs). A total of 33 studies addressing SM practice in Mexican populations. Read More

World J Surg Oncol 2022 Jun 25;20(1):216. Epub 2022 Jun 25.

Department of Faculty Surgery №2, I.M.Sechenov First Moscow State Medical University, Moscow, Russia.

Background: Laparoscopic surgery has justified its efficacy in the treatment of early gastric cancer. There are limited data indicating the eligibility of laparoscopic interventions in locally advanced gastric cancer. Publications describing the safety of laparoscopic techniques in the treatment of local and metastatic gastric cancer complicated by bleeding and stenosis are scarce. Read More

Diagn Pathol 2022 Jun 25;17(1):53. Epub 2022 Jun 25.

Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, 260 CMET, Chicago, USA.

Background: Primary intestinal T-cell lymphomas are uncommon malignancies that pose a diagnostic dilemma, because the clinical features and imaging findings commonly overlap with those encountered in inflammatory bowel diseases.

Case Presentation: The current clinical case report describes the clinical history, laboratory findings and histopathological analysis from a patient with non-specific gastrointestinal symptoms with a presumptive clinical diagnosis of inflammatory bowel disease, and two intestinal biopsy specimens with non-specific findings. Due to the persistent symptoms a third biopsy was consistent with primary intestinal T-cell lymphoma, a diagnosis that was elusive for months after the initial presentation. Read More

BMC Cancer 2022 Jun 25;22(1):700. Epub 2022 Jun 25.

Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Background: Systemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the prognostic value of surrogate systemic inflammation and IR indices in patients with cancer.

Methods: This multicenter prospective study included 5,221 patients with cancer, with a mean age of 59. Read More

Ann Surg Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Upper Abdominal Surgery, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: Recent research indicates long-term survival benefits of minimally invasive esophagectomy (MIE) compared with open esophagectomy (OE) for patients with esophageal and gastroesophageal junction (GEJ) cancers, but there is a need for more population-based studies.

Methods: We conducted a prospective population-based nationwide cohort study including all patients in Sweden diagnosed with esophageal or junctional cancer who underwent a transthoracic esophagectomy with intrathoracic anastomosis. Data were collected from the Swedish National Register for Esophageal and Gastric Cancer in 2006-2019. Read More

J Integr Med 2022 Jun 15. Epub 2022 Jun 15.

Department of Botany, University of Calcutta, Kolkata, West Bengal 700019, India. Electronic address:

Objective: "Multi-targeting" drugs can prove fruitful to combat drug-resistance of multifactorial disease-cervical cancer. This study envisioned to reveal if Thuja homeopathic mother tincture (MT) and its bioactive component could combat human papillomavirus (HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated warts.

Methods: Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species (ROS) generation by 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) staining and loss in mitochondrial membrane potential (MtMP) by rhodamine 123 (Rh123) staining. Read More

Int Dent J 2022 Jun 1. Epub 2022 Jun 1.

Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Aims: It has been reported that there are a certain percentage of COVID-19 patients who recover but suffer from devastating permanent organ damage or failure. Others suffer from long Covid syndrome, with prolonged symptoms that persist more than 12 weeks. However, there is scarcity of literature regarding the provision of dental treatment for these two groups of patients. Read More

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, California; Department of Orthopedic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.

Objective: Parkinson's Disease (PD) is a risk factor for worse surgical outcomes. The degree to which Parkinson's affects outcomes in cervical spine surgery is not well understood. Therefore, we characterize rates of postoperative complications among patients with PD who undergo cervical spine surgery. Read More

Int J Radiat Oncol Biol Phys 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.

Purpose: Medical operability is prognostic for survival after SABR in primary malignancies. This study investigates the prognostic significance of medical operability and total versus subtotal ablation of all oligometastatic disease sites.

Material/methods: Consecutive patients with 1-5 sites of active extracranial oligometastases had medical operability status and presence of subtotal versus total metastatic ablation recorded prospectively on an institutional database. Read More

Chem Biol Interact 2022 Jun 22;363:110026. Epub 2022 Jun 22.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Background: and Purpose: Inflammatory Bowel Disease (IBD) is a persistent bio-psychological disorder with the absence of actual pathological reason. Association between IBD and isotretinoin has been reported by many human and in vitro studies. However, in this study, our focus is on finding the causal relationship between IBD and isotretinoin for the development of a new animal model. Read More

J Ethnopharmacol 2022 Jun 22:115498. Epub 2022 Jun 22.

Univ Coimbra, Faculty of Pharmacy, Laboratory of Pharmacology and Pharmaceutical Care, 3000-548, Coimbra, Portugal; Univ Coimbra, Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), 3000-548, Coimbra, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology, 3000-548, Coimbra, Portugal. Electronic address:

Ethnopharmacological Relevance: Agrimonia eupatoria L., a plant which belongs to the Rosaceae family, is widespread in temperate regions, particularly throughout the northern hemisphere. In folk medicine, this plant species has been used for its astringent, anti-inflammatory, analgesic and hypotensive properties as well as in gastrointestinal disorders. Read More

Sci Total Environ 2022 Jun 22:156884. Epub 2022 Jun 22.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The potential health effects of microplastics (MPs) have become a public concern due to their ubiquitous in the environment and life. Numerous studies have demonstrated that a high dose of MPs can adversely affect gastrointestinal health. However, few studies have focused on the impact of microplastics on patients' health with respect to gastrointestinal diseases. Read More

Mol Cell 2022 Jun 18. Epub 2022 Jun 18.

Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

Cancer mortality is primarily a consequence of its metastatic spread. Here, we report that methionine sulfoxide reductase A (MSRA), which can reduce oxidized methionine residues, acts as a suppressor of pancreatic ductal adenocarcinoma (PDA) metastasis. MSRA expression is decreased in the metastatic tumors of PDA patients, whereas MSRA loss in primary PDA cells promotes migration and invasion. Read More

Int J Surg Case Rep 2022 Jun 21;96:107331. Epub 2022 Jun 21.

Department of Surgery, District General Hospital, Mannar, Sri Lanka.

Introduction And Importance: Foreign body-induced perforations of the ileum are rare consequences among adults.

Presentation Of Case: This is a case report of a delayed presentation of an ileal perforation and concurrent faecal peritonitis presented as an acute abdomen, resultant from an ingested fishbone, which led to fatality despite urgent laparotomy.

Clinical Discussion: Perforations following ingested foreign bodies are frequently unanticipated clinically, and diagnosed during advanced imaging studies or surgical interventions. Read More

Aquat Toxicol 2022 Jun 13;249:106223. Epub 2022 Jun 13.

Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie UNICAEN, Sorbonne Université, MNHN, UPMC Univ Paris 06, UA, CNRS 8067, IRD 207, Esplanade de la paix, Caen F-14032, France. Electronic address:

Among the anthropogenic sources releasing metallic species into the marine environment, the galvanic anode cathodic protection system (GACP) is widely used to protect submerged metallic structures from corrosion. Galvanic anodes are an alloy of metals of which the main component is aluminum or zinc. Very few studies were performed to study their potential biological effects. Read More

Endocrine 2022 Jun 25. Epub 2022 Jun 25.

SSD Medicina interna ad indirizzo onco-endocrinologico, Università di Parma - Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

Purpose: Patients undergoing thyroidectomy for differentiated thyroid cancer (DTC) may require 131-radioactive iodine (RAI) administration for remnant ablation or disease treatment. After ingestion, RAI resides within the gastrointestinal tract potentially leading to mucosal damage and abnormalities in the absorption of levothyroxine (LT4). The aim of this study was to evaluate whether serum FT4 peak, induced by a LT4 challenge, changes according to the LT4 formulation (solid or liquid) in both RAI and non-RAI-treated DTC patients. Read More

ANZ J Surg 2022 Jun 25. Epub 2022 Jun 25.

Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Aliment Pharmacol Ther 2022 Jun 25. Epub 2022 Jun 25.

Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Background: Chicago Classification version 4.0 (CCv4.0) introduced stringent diagnostic criteria for oesophagogastric junction outflow obstruction (EGJOO), in order to increase the clinical relevance of the diagnosis, although this has not yet been demonstrated. Read More

Compr Rev Food Sci Food Saf 2022 Jun 24. Epub 2022 Jun 24.

School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, P. R. China.

Food allergens are closely related to their gastrointestinal digestion fate, but the changes in food allergens during digestion and related mechanisms are quite complicated. This review presents in detail digestion models for predicting allergenicity, the fates of food allergens in oral, gastric and duodenal digestion, and the applications of digestomics in mapping IgE-binding epitopes of digestion-resistant peptides. Moreover, this review highlights the structure-activity relationships of food allergens during gastrointestinal digestion. Read More

J Pak Med Assoc 2022 Jun;72(6):1211-1213

Department of Pathology, Liaquat National Hospital, Karachi, Pakistan.

Gastric Schwannomas are rare, submucosal mesenchymal tumours arising from the nerve plexus of the Gut wall. They have an incidence rate of 0.2% of all Gastric tumours. Read More

J Pak Med Assoc 2022 Jun;72(6):1205-1207

Department of Oral Medicine, Shaheed Zulfiqar Ali Bhutto Medical University/School of Dentistry, Islamabad, Pakistan.

Rumination syndrome is a functional gastrointestinal disorder with effortless, non-projectile regurgitation seen mostly in paediatric population and seems to be an uncommon gastrointestinal disorder due to lack of awareness among physicians. Here we report three such cases in adult patients that were labeled "refractory vomiting". No such case has been reported from Pakistan which makes this a unique case series. Read More

J Pak Med Assoc 2022 Jun;72(6):1188-1192

Department of Anaesthesia, Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan.

Chronic gastrointestinal (GI) diseases in children present with a wide range of symptoms. Limited resources in Paediatric Gastroenterology in developing countries like Pakistan cause considerable difficulties in managing children with chronic GI diseases in a timely fashion. This retrospective descriptive study aimed to determine the spectrum and outcomes of chronic GI diseases in children. Read More

Pharmazie 2022 Jun;77(6):196-201

Department of Pharmacy, Hokkaido University, Sapporo, Japan; Laboratory of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan;, Email:

Chemotherapy-induced nausea and vomiting (CINV) is one of the most serious adverse effects of cancer therapy. Cancer patients frequently use acid suppressants (AS) for palliation of gastrointestinal symptoms associated with malignancy and/or anticancer therapy. AS are suggested as an additional option for CINV management in several antiemetic guidelines, although their efficacy remains unknown. Read More

BMC Vet Res 2022 Jun 24;18(1):245. Epub 2022 Jun 24.

Global Clinical Nutrition and Claims, Hill's Pet Nutrition, Inc., P.O. Box 1658, 1035 43rd St., Topeka, KS, 66601-1658, USA.

Background: Chronic large bowel diarrhea is a common occurrence in pet dogs. While nutritional intervention is considered the primary therapy, the metabolic and gut microfloral effects of fiber and polyphenol-enriched therapeutic foods are poorly understood.

Methods: This prospective clinical study enrolled 31 adult dogs from private veterinary practices with chronic, active large bowel diarrhea. Read More

J Med Case Rep 2022 Jun 25;16(1):248. Epub 2022 Jun 25.

Division of Neurology, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Hereditary transthyretin amyloidosis is an uncommon multisystem disorder caused by mutation of the transthyretin protein, leading to peripheral neuropathy often with autonomic features, cardiomyopathy, or a mixed phenotype. Multiple other organ systems can be involved with ophthalmologic, renal, hematologic, gastrointestinal, and/or genitourinary symptoms and signs. This often results in assessments by multiple specialists and significant delays before the diagnosis is recognized. Read More

AAPS PharmSciTech 2022 Jun 24;23(6):175. Epub 2022 Jun 24.

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.

Onychomycosis is the most common fungal infection of the nail affecting the skin under the fingertips and the toes. Currently, available therapy for onychomycosis includes oral and topical therapies, either alone or in combination. Oral antifungal medication has been associated with poor drug bioavailability and potential gastrointestinal and systemic side effects. Read More

Clin Pharmacokinet 2022 Jun 25. Epub 2022 Jun 25.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

Purpose: Intravenous vitamin C (IVC) is used in a variety of disorders with limited supporting pharmacokinetic data. Herein we report a pharmacokinetic study in healthy volunteers and cancer participants with IVC doses in the range of 1-100 g.

Methods: A pharmacokinetic study was conducted in 21 healthy volunteers and 12 oncology participants. Read More

Nat Rev Neurol 2022 Jun 24. Epub 2022 Jun 24.

Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, Canada.

Evidence for a close bidirectional link between the brain and the gut has led to a paradigm shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal dysfunction is a prominent feature. Over the past decade, numerous high-quality preclinical and clinical publications have shed light on the highly complex relationship between the gut and the brain in PD, providing potential for the development of new biomarkers and therapeutics. With the advent of high-throughput sequencing, the role of the gut microbiome has been specifically highlighted. Read More

Oncogenesis 2022 Jun 24;11(1):36. Epub 2022 Jun 24.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510407, Guangzhou, Guangdong, China.

J Integr Med 2022 Jun 10. Epub 2022 Jun 10.

School of Pharmacy, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Background: Traditional Chinese medicine (TCM) is becoming a popular complementary approach in pediatric oncology. However, few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.

Objective: We explored the patterns of TCM use and its efficacy in children with cancer, using a systematic review, meta-analysis and data mining study. Read More