367,457 results match your criteria Gastrointestinal Stromal Tumors – Leiomyoma Leiomyosarcoma


Australia’s notifiable disease status, 2015: Annual report of the National Notifiable Diseases Surveillance System

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Commun Dis Intell (2018) 2019 Mar 15;43. Epub 2019 Mar 15.

In 2015, 67 diseases and conditions were nationally notifiable in Australia. States and territories reported a total of 320,480 notifications of communicable diseases to the National Notifiable Diseases Surveillance System, an increase of 16% on the number of notifications in 2014. In 2015, the most frequently notified diseases were vaccine preventable diseases (147,569 notifications, 46% of total notifications), sexually transmissible infections (95,468 notifications, 30% of total notifications), and gastrointestinal diseases (45,326 notifications, 14% of total notifications). Read More

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Bloating and Abdominal Distension: Clinical Approach and Management.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Division of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.

Functional abdominal bloating and distension (FABD) are common gastrointestinal complaints, encountered on a daily basis by gastroenterologists and healthcare providers. Functional abdominal bloating is a subjective sensation that is commonly associated with an objective abdominal distension. FABD may be diagnosed as a single entity (the sole or cardinal complaint) or may overlap with other functional gastrointestinal disorders such as functional constipation, irritable bowel syndrome, and functional dyspepsia. Read More

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http://dx.doi.org/10.1007/s12325-019-00924-7DOI Listing

A rare cause of abdominal pain with fever.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Internal Medicine, Hospital and University Center of Coimbra, Coimbra, Portugal.

An 89-year-old man presented to the emergency department with a 1-month history of upper right quadrant pain, worsened in the last 3 days and accompanied by fever and chills. On physical examination, he had scleral icterus and right upper quadrant tenderness. Laboratory findings showed hyperbilirubinemia, elevated liver enzymes and C reactive protein. Read More

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http://dx.doi.org/10.1136/bcr-2018-228401DOI Listing

Chondrolipoma of the stomach.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Upper Gastrointestinal and Hepatobiliary Unit, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

Chondrolipoma, a rare variant of a lipoma, is a benign mesenchymal neoplasm characterised by mature adipocytes with neoplastic hyaline cartilage formation. We describe the first case of a gastric chondrolipoma. The tumour was completely excised via laparoscopic gastric wedge resection with uneventful postoperative recovery. Read More

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http://dx.doi.org/10.1136/bcr-2018-228757DOI Listing

Rare complication of milk-alkali ingestion: severe pancreatitis and acute kidney injury in a chronic hypocalcaemic patient with DiGeorge's syndrome.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Department of Internal Medicine, St Vincent Charity Medical Center, Cleveland, Ohio, USA.

Injudicious use of over-the-counter calcium supplements has resulted in increased incidences of hypercalcaemia and related complications. We present a case of acute pancreatitis in a chronic hypocalcaemic patient of DiGeorge's syndrome. The patient came into the ED with sepsis syndrome, right upper quadrant and epigastric pain and no obvious source of infection. Read More

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http://dx.doi.org/10.1136/bcr-2018-226761DOI Listing

Lanthanum phosphate binder-induced iron deficiency anaemia.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

US Air Force Hospital Keesler AFB, Keesler AFB, Mississippi, USA.

Lanthanum carbonate is a phosphate binder that is used to reduce serum phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum forms insoluble lanthanum phosphate complexes that are supposed to pass through the gastrointestinal (GI) tract unabsorbed. Phosphate binders have been reported to deposit in the GI tract and can cause mucosal injury. Read More

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http://dx.doi.org/10.1136/bcr-2018-226157DOI Listing

The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma.

Eur J Cancer 2019 Mar 14;112:1-8. Epub 2019 Mar 14.

Tumor- und Brustzentrum ZeTuP, St. Gallen, Switzerland.

Multimodal primary treatment of localised adenocarcinoma of the stomach, the oesophagus and the oesophagogastric junction (AEG) was reviewed by a multidisciplinary expert panel in a moderated consensus session. Here, we report the key points of the discussion and the resulting recommendations. The exact definition of the tumour location and extent by white light endoscopy in conjunction with computed tomography scans is the backbone for any treatment decision. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.106DOI Listing

Techniques for splenic vein reconstruction after pancreaticoduodenectomy with portal vein resection for pancreatic cancer.

HPB (Oxford) 2019 Mar 13. Epub 2019 Mar 13.

Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Japan. Electronic address:

Background: Pancreaticoduodenectomy (PD) with splenic vein (SV) ligation may result in sinistral portal hypertension (SPH). The aim of this study was to compare the outcomes of various types of SV reconstruction to prevent SPH and to define the optimal reconstruction method.

Methods: This study included patients who underwent PD with SV resection and reconstruction for pancreatic cancer between December 2013 and June 2017. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.01.017DOI Listing

SGL5213, a novel and potent intestinal SGLT1 inhibitor, suppresses intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.

Eur J Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan. Electronic address:

Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from digested nutrients in the gastrointestinal tract. Intestinal SGLT1 inhibition reduces post-prandial hyperglycemia and enhances the increase of plasma glucagon-like peptide-1 (GLP-1) levels. SGL5213 is a novel and potent intestinal SGLT1 inhibitor. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.023DOI Listing

Perioperative management for gastrointestinal surgery after instituting interventions initiated by the Japanese Society of Surgical Metabolism and Nutrition.

Asian J Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.

Background: In 2012, the Japanese Society for Surgical Metabolism and Nutrition introduced the Essential Strategy for Early Normalization after Surgery with Patient's Excellent Satisfaction (ESSENSE) program to improve the perioperative management of gastrointestinal surgery. The ESSENSE program aimed to minimize ineffective perioperative management practices, and achieve adequate analgesia to expedite the return to work and activities of daily living.

Methods: After educating relevant facilities about the ESSENSE program in 2012, we conducted questionnaire-based surveys in selected institutions in 2013 and 2016. Read More

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http://dx.doi.org/10.1016/j.asjsur.2019.02.007DOI Listing

Extracraniofacial anomalies in craniofacial microsomia: retrospective analysis of 991 patients.

Int J Oral Maxillofac Surg 2019 Mar 13. Epub 2019 Mar 13.

The Dutch Craniofacial Centre, Department of Oral and Maxillofacial Surgery, Erasmus University Medical Centre, Sophia's Children's Hospital Rotterdam, Rotterdam, The Netherlands; The Craniofacial Unit, Great Ormond Street Hospital, London, UK; Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, USA.

Craniofacial microsomia (CFM) is characterized by unilateral or bilateral underdevelopment of the facial structures arising from the first and second pharyngeal arches, but extracraniofacial anomalies may also be present. This retrospective study provides an overview of the prevalence, types, and characteristics of extracraniofacial anomalies in patients with CFM. All patients diagnosed with CFM seen at four craniofacial centres were included. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.01.031DOI Listing

Early colorectal cancer: diagnosis, treatment and survivorship care.

Crit Rev Oncol Hematol 2019 Apr 10;136:20-30. Epub 2019 Feb 10.

UOC Oncologia Medica, Ospedale Umberto I, Via Giuseppe Testaferrata 1, 96100, Siracusa, Italy. Electronic address:

CRC is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death in the world. With advances in treatment, colorectal cancer is being transformed from a deadly disease to an illness that is increasingly curable. With this transformation has come increased interest in the unique problems, risks, needs, and concerns of survivors who have completed treatment and are cancer-free. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.01.023DOI Listing

Fungal empyema in complicated chronic pancreatitis: A rare possibility.

Int J Surg Case Rep 2019 Mar 7;57:25-27. Epub 2019 Mar 7.

Section of Cardiothoracic, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Introduction: Fungal empyema a rare cause of empyema thoracis is commonly associated with nosocomial infection or gastrointestinal disease with very high mortality. Its association with chronic pancreatitis is rarely been described.

Presentation Of Case: We present a case of young male known alcoholic with chronic pancreatitis and cystgastrostomy who presented with dyspnea and fever. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.040DOI Listing

Upper Gastrointestinal Obstruction Caused by Gastrolithiasis After Laparoscopic Roux-en-Y Gastric Bypass: a Case Report.

Obes Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, No.95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.

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http://dx.doi.org/10.1007/s11695-018-03674-7DOI Listing

Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA.

Langenbecks Arch Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Pathology, FAU Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common soft tissue tumors of the GI tract. Studies have been published reporting additional neoplasms in GIST patients. This study aimed to evaluate possible associations of mutation type, morphology, and clinical aspects of GISTs. Read More

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http://dx.doi.org/10.1007/s00423-019-01773-2DOI Listing

Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands.

J Med Genet 2019 Mar 15. Epub 2019 Mar 15.

Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is present in more than 90% of resected gastric cancer tissues. However, although widely regarded as a pre-cancerous tissue, its genetic characteristics have not been well studied.

Methods: Immunohistochemistry using Trefoil factor 2 (TFF2) antibodies was used to identify TFF2-positive SPEM cells within SPEM glands in the stomach of -infected mice and human clinical samples. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105752DOI Listing

Inhibition of Serotonin Synthesis May Have Antitumor Activity? Long-Term Efficacy in a Patient with Gastrointestinal Neuroendocrine Tumor.

Oncologist 2019 Mar 15. Epub 2019 Mar 15.

Medical Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.

In this article, we propose, based on a clinical case, the potential antitumor effect related to the inhibition of serotonin in neuroendocrine tumors (NETs). Currently, the only drug that exists for the symptomatic treatment of carcinoid syndrome refractory to somatostatin analogues is telotristat, based on its pivotal study, the TELESTAR trial. Based on the existing preclinical rationale, it seems that the inhibition of serotonin may have an antitumoral role in NETs. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0776DOI Listing

Circulating Inflammation Markers and Risk of Gastric and Esophageal Cancers: A Case-Cohort Study Within the Japan Public Health Center-Based Prospective Study.

Cancer Epidemiol Biomarkers Prev 2019 Mar 15. Epub 2019 Mar 15.

Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland.

Circulating inflammation proteins may be important mediators or markers of carcinogenic mechanisms. There have been few studies with limited numbers of analytes in patients with upper gastrointestinal (GI) tract tumors. We therefore evaluated risk associations of gastric and esophageal cancers with prediagnostic levels of a wide range of these molecules. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1157DOI Listing

Identification of a molecular switch that controls expression of the mannose-specific adhesin, Msa, in .

Appl Environ Microbiol 2019 Mar 15. Epub 2019 Mar 15.

Bioneer A/S, Hørsholm, Denmark.

Some lactic acid bacteria, especially , possess adhesive properties enabling colonization of the human gastrointestinal tract. Two probiotic strains, WCSF1 and 299v, display highly different mannose-specific adhesion, with 299v being superior to WCFS1 based on a yeast agglutination assay. A straightforward correlation between the mannose-adhesion capacity and domain composition of the mannose-specific adhesin (Msa) in the two strains has not been demonstrated previously. Read More

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http://dx.doi.org/10.1128/AEM.02954-18DOI Listing

Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations.

Eur J Pharm Sci 2019 Mar 12. Epub 2019 Mar 12.

Merck KGaA, Darmstadt, Germany. Electronic address:

Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation inhibitor (PI) to sustain the increased concentrations to ensure that sufficient absorption will take place from the gastrointestinal tract. Recent advances in understanding the importance of drug-polymer interaction for successful precipitation inhibition have been encouraging. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.03.006DOI Listing

Cp1-11 peptide/insulin complex loaded pH-responsive nanoparticles with enhanced oral bioactivity.

Int J Pharm 2019 Mar 12. Epub 2019 Mar 12.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:

To improve the oral efficiency of insulin, a novel oral insulin delivery system was developed, to protect the insulin from destruction, and to deliver monomeric insulin with higher bioactivity. The oral insulin delivery system was developed by using chitosan/alginate nanoparticles as carriers for the oral delivery of Cp1-11 peptide/insulin complex (Cp1-11 peptide/Insulin Loaded Nanoparticle, CILN). There is a supramolecular interaction between the insulin and the Cp1-11 peptide, which could inhibit insulin aggregation and improve its bioactivity. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.03.020DOI Listing

Putting the Horse Back in the Barn: Right-Sizing Use of Anesthesia Assistance for Routine Gastrointestinal Endoscopy.

Authors:
Megan A Adams

Clin Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Center for Clinical Management Research, Department of Veterans Affairs, VA Ann Arbor Health Care System, Ann Arbor, Michigan; Division of Gastroenterology, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Institute for Healthcare Policy and Innovation, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.02.047DOI Listing

Black Esophagus: A Rare Cause of Upper Gastrointestinal Bleeding.

Clin Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1016/j.cgh.2019.02.046DOI Listing

National trends, outcomes, and costs of radiation therapy in the management of low- and high-intermediate risk endometrial cancer.

Gynecol Oncol 2019 Mar;152(3):439-444

Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America. Electronic address:

Objective: To assess treatment patterns, outcomes, and costs for women with low-(LIR) and high-intermediate risk endometrial cancer (HIR) who are treated with and without adjuvant radiotherapy.

Methods: All patients with stage I endometrioid endometrial cancer who underwent surgery from 2000 to 2011 were identified from the SEER-Medicare database. LIR was defined as G1-2 tumors with <50% myometrial invasion or G3 with no invasion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183136
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http://dx.doi.org/10.1016/j.ygyno.2018.11.005DOI Listing
March 2019
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Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.

BMC Genomics 2019 Mar 15;20(1):218. Epub 2019 Mar 15.

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infect livestock and companion animals, and there are growing concerns regarding the reduced efficacy in some human-infective helminths. Understanding the mechanisms by which resistance evolves is the focus of increasing interest; robust genetic analysis of helminths is challenging, and although many candidate genes have been proposed, the genetic basis of resistance remains poorly resolved. Read More

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http://dx.doi.org/10.1186/s12864-019-5592-6DOI Listing

Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, University of Medical Sciences, Szwajcarska Street 3, 61-285 Poznań, Poland.

Mucins are large -glycoproteins with high carbohydrate content and marked diversity in both the apoprotein and the oligosaccharide moieties. All three mucin types, trans-membrane (e.g. Read More

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http://dx.doi.org/10.3390/ijms20061288DOI Listing

Gastro-splenic fistula, a rare presentation of sickle cell disease patient with splenic abscess: Case report and literature review.

Int J Surg Case Rep 2019 Mar 5;57:22-24. Epub 2019 Mar 5.

Department of Surgery, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Saudi Arabia. Electronic address:

Introduction: Hemoglobinopathies such as Thalassemia and Sickle Cell Disease are risk factors for splenic abscess formation. Gastro-splenic fistula is a rare complication of splenic abscess. In the literature, there are no reported cases of gastro-splenic fistula in patients with hemoglobinopathies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193010
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http://dx.doi.org/10.1016/j.ijscr.2019.02.039DOI Listing
March 2019
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Small bowel obstruction after gastric by-pass: Diagnostic limits and percutaneous drain. A paradigmatic case.

Int J Surg Case Rep 2019 Mar 5;57:15-18. Epub 2019 Mar 5.

General and Emergency Surgery Unit of Fucito Hospital, University Hospital of Salerno, Italy. Electronic address:

Background: Obesity is showing a constant increase worldwide, making it the major public health problem. Bariatric surgery seems to be the best treatment for these to achieve a good excess weight loss. Gastric by-pass (GBP) is one the most important bariatric procedure, but there are a lot of complications as bowel obstruction for internal hernia, fistula and intussusception. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.036DOI Listing

An integrated analysis of safety and tolerability of etelcalcetide in patients receiving hemodialysis with secondary hyperparathyroidism.

PLoS One 2019 15;14(3):e0213774. Epub 2019 Mar 15.

Amgen Inc., Thousand Oaks, California, United States of America.

Background: Calcimimetics have been shown to be effective and safe therapies for the treatment of secondary hyperparathyroidism (sHPT), a serious complication of disordered mineral metabolism associated with dialysis-dependent chronic kidney disease. Etelcalcetide, a recently approved intravenous calcimimetic, reduces serum parathyroid hormone (PTH), calcium, phosphorus, and fibroblast growth factor-23 concentrations. Here we report the first integrated safety profile of etelcalcetide using pooled data from five pivotal clinical trials. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213774PLOS
March 2019
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Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN.

Anticancer Drugs 2019 Apr;30(4):347-355

Department of Gastrointestinal Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu Province, China.

Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR). This study investigated the impacts of caffeine and theophylline on gastric cancer cell apoptosis and autophagy using a gastric cancer cell line (MGC-803) and a nude mouse model. Peritumoural and tumour tissues were collected from five patients diagnosed with gastric carcinoma who underwent laparoscopic radical gastrectomy at our hospital. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000724DOI Listing
April 2019
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A recombinant canine distemper virus expressing interleukin-7 enhances humoral immunity.

J Gen Virol 2019 Mar 15. Epub 2019 Mar 15.

1​State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, PR China.

Canine distemper (CD) causes gastrointestinal and respiratory and/or neurological signs and results in high morbidity and mortality, remaining a threat to carnivores around the world. Live-attenuated vaccines have been widely used to reduce the number of CD outbreaks, but efforts are still needed to improve immune efficiency. Interleukin-7 (IL-7) has been reported to boost host immunity by recruiting follicle helper T (TFH) or germinal center (GC) B cells. Read More

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http://dx.doi.org/10.1099/jgv.0.001247DOI Listing

Recombinant human thyrotropin (rhTSH) versus Levo-thyroxine withdrawal in radioiodine therapy of differentiated thyroid cancer patients: differences in abdominal absorbed dose.

Endocrine 2019 Mar 14. Epub 2019 Mar 14.

Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.

Purpose: In DTC patients, 131-radioiodine therapy has routinely been used for many years for thyroid remnant ablation after thyroid surgery. To date, two different strategies can be used to achieve sufficient TSH stimulation on thyroid remnant: (I) Levo-thyroxine withdrawal or (II) rhTSH stimulation. The aim of our study was to compare the abdominal absorbed dose ratio between differentiated thyroid cancer patients who underwent thyroid remnant ablation after either L-T4 withdrawal or rhTSH stimulation. Read More

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http://dx.doi.org/10.1007/s12020-019-01897-xDOI Listing

Coincidental Detection of Gastrointestinal Stromal Tumors During Laparoscopic Bariatric Procedures-Data and Treatment Strategy of a German Reference Center.

Obes Surg 2019 Mar 14. Epub 2019 Mar 14.

Division of Bariatric Surgery, Clinic of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital, Liebigstrasse. 20, D-4015, Leipzig, Germany.

Introduction: Intraoperative pathologic findings during bariatric surgery are relatively rare. Gastrointestinal stromal tumors (GISTs) are commonly located in the stomach and account for < 1% of all neoplasms of the alimentary tract. Coincidental detection of GISTs during bariatric surgery has been reported around 0. Read More

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http://dx.doi.org/10.1007/s11695-019-03782-yDOI Listing

Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Faculty of Pharmaceutical Sciences, Aomori University, 2-3-1 Kohbata, Aomori-city, Aomori, 030-0943, Japan.

Background: Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM.

Aims: The purpose of the present study is to investigate the coexistence of alterations of GI function in the reserpine-induced myalgia (RIM) rat, a validated FM model associated with disruption of monoamine system. Read More

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http://dx.doi.org/10.1007/s10620-019-05577-8DOI Listing

Safety of Inactivated Influenza Vaccine in Cancer Patients Receiving Immune Checkpoint Inhibitors (ICI).

Clin Infect Dis 2019 Mar 15. Epub 2019 Mar 15.

Infection control.

Background: Cancer patients are at a higher risk for developing influenza (flu) related complications. It is unclear if the flu vaccine exacerbates immune events in patients treated with ICIs.

Methods: We conducted an IRB-approved retrospective review of advanced cancer patients on ICIs who received the flu vaccine during three consecutive seasons; 2014-15, 15-16, and 16-17. Read More

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http://dx.doi.org/10.1093/cid/ciz202DOI Listing

Circadian rhythms: a regulator of gastrointestinal health and dysfunction.

Expert Rev Gastroenterol Hepatol 2019 Mar 15. Epub 2019 Mar 15.

a Rush University Medical Center , Rush Department of Medicine, Division of Digestive Diseases and Nutrition , Chicago , Illinois , USA.

Introduction: Circadian rhythms regulate much of gastrointestinal physiology including cell proliferation, motility, digestion, absorption, and electrolyte balance. Disruption of circadian rhythms can have adverse consequences including the promotion of and/or exacerbation of a wide variety of gastrointestinal disorders and diseases. Areas covered: In this review, we evaluate some of the many functions that are regulated by circadian rhythms and how dysregulation of these functions may contribute to disease. Read More

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http://dx.doi.org/10.1080/17474124.2019.1595588DOI Listing

Fabrication of plant-based vitamin D-fortified nanoemulsions: influence of carrier oil type on vitamin bioaccessibility.

Food Funct 2019 Mar 15. Epub 2019 Mar 15.

Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA.

The influence of carrier oil type (corn, fish, or flaxseed oil) on the production, stability, and simulated gastrointestinal behavior of vitamin-fortified nanoemulsions was studied. The nanoemulsions were formulated using pea protein as an emulsifier since there is increasing interest in substituting artificial and animal-based food ingredients with natural plant-based alternatives. Lipid digestion and vitamin D3 bioaccessibility were measured when the nanoemulsions were subjected to a three-stage in vitro gastrointestinal tract: oral, gastric, and small intestinal. Read More

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http://dx.doi.org/10.1039/c9fo00116fDOI Listing

Serum biomarker panels for the diagnosis of gastric cancer.

Cancer Med 2019 Mar 14. Epub 2019 Mar 14.

Department of Gastrointestinal Surgery, Lishui Municipal Central Hospital, Lishui, Zhejiang, China.

Gastric cancer is a leading cause of mortality due to neoplastic disease. Although early detection of gastric cancers can decrease the mortality rate, it remains a diagnostic challenge because of the lack of effective biomarkers. In this study, fifteen gastric cancer patients and ten healthy subjects were recruited to assess novel serum biomarkers for gastric cancer using antibody microarray technology. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2055
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http://dx.doi.org/10.1002/cam4.2055DOI Listing
March 2019
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Ectopic expression of miR-944 impairs colorectal cancer cell proliferation and invasion by targeting GATA binding protein 6.

J Cell Mol Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastrointestinal Surgery & Hernia and Abdominal Wall Surgery, The First Hospital, China Medical University, Shenyang, Liaoning, China.

miR-944 is a microRNA that has been reported to play different important roles in the progression of cancer. Colorectal cancer (CRC) is a common cancer worldwide. A recent study has confirmed that miR-944 plays a tumour suppressive role in CRC. Read More

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http://dx.doi.org/10.1111/jcmm.14245DOI Listing
March 2019
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Isolation and Identification of Cellulolytic Bacteria from Gastrointestinal Tract of Arabian Horse and Investigation of Their Effect on the Nutritional Value of Wheat Straw.

J Appl Microbiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Animal Sciences, Sari Agricultural Sciences and Natural Resources University, P.O. Box 48181-68984, Sari, Iran.

Aims: This study was conducted to isolate and identify the cellulolytic bacteria from gastrointestinal tract of Arabian horse and investigate their effect on the nutritional value of wheat straw.

Methods And Results: Fresh feces were collected from four Arabian horses. The cellulose-hydrolytic bacteria were isolated by using medium amended with carboxymethyl cellulose (CMC). Read More

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http://dx.doi.org/10.1111/jam.14251DOI Listing

Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation.

J Intern Med 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Alterations in the bacteria that reside in our gastrointestinal tract play a role in the pathogenesis and progression of many disorders including liver and gastrointestinal diseases. Both qualitative (composition) and quantitative (amount) changes in gut microbes are associated with increased susceptibility to liver disease. Importantly, the intestinal microbiota is involved in the regulation of many host signalling pathways via the generation of different metabolites. Read More

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http://dx.doi.org/10.1111/joim.12892DOI Listing

Cholecystokinin (CCK) Regulation of Pancreatic Acinar Cells: Physiological Actions and Signal Transduction Mechanisms.

Authors:
John A Williams

Compr Physiol 2019 Mar 14;9(2):535-564. Epub 2019 Mar 14.

University of Michigan, Departments of Molecular & Integrative Physiology and Internal Medicine (Gastroenterology), Ann Arbor, Michigan, USA.

Pancreatic acinar cells synthesize and secrete about 20 digestive enzymes and ancillary proteins with the processes that match the supply of these enzymes to their need in digestion being regulated by a number of hormones (CCK, secretin and insulin), neurotransmitters (acetylcholine and VIP) and growth factors (EGF and IGF). Of these regulators, one of the most important and best studied is the gastrointestinal hormone, cholecystokinin (CCK). Furthermore, the acinar cell has become a model for seven transmembrane, heterotrimeric G protein coupled receptors to regulate multiple processes by distinct signal transduction cascades. Read More

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http://dx.doi.org/10.1002/cphy.c180014DOI Listing

Slc26 Family of Anion Transporters in the Gastrointestinal Tract: Expression, Function, Regulation, and Role in Disease.

Compr Physiol 2019 Mar 15;9(2):839-872. Epub 2019 Mar 15.

Hannover Medical School, Department of Gastroenterology, Hannover, Germany.

SLC26 family members are multifunctional transporters of small anions, including Cl , HCO , sulfate, oxalate, and formate. Most SLC26 isoforms act as secondary (coupled) anion transporters, while others mediate uncoupled electrogenic transport resembling Cl channels. Of the 11 described SLC26 isoforms, the SLC26A1,2,3,6,7,9,11 are expressed in the gastrointestinal tract, where they participate in salt and water transport, surface pH-microclimate regulation, affect the microbiome composition, the absorption, and secretion of oxalate and sulfate, and other functions that require further study. Read More

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http://dx.doi.org/10.1002/cphy.c180027DOI Listing

Gastric cancer and paraneoplastic dermatomyositis as complications of an unrecognized juvenile polyposis syndrome.

Z Gastroenterol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Juvenile polyposis syndrome is a rare autosomal-dominant disorder characterized by multiple hamartomatous polyps in the gastrointestinal tract. It is associated with an increased risk of gastrointestinal cancer. We report the case of a 49-year-old woman presenting with proximal muscle weakness, weight loss, severe anemia, and melena. Read More

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http://dx.doi.org/10.1055/a-0855-4404DOI Listing

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis.

Exp Clin Endocrinol Diabetes 2019 Mar 14. Epub 2019 Mar 14.

School of Medicine, University of Auckland, Auckland, New Zealand.

Aim: The study aimed to investigate the associations between glycaemic control after acute pancreatitis and gastrointestinal motility, using plasma motilin concentration and gastroparesis cardinal symptom index score as proxies.

Methods: This cross-sectional study recruited a total of 93 individuals after acute pancreatitis. Gastroparesis cardinal index scores, demographic and anthropometric factors, as well as pancreatitis-related factors were analysed. Read More

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http://dx.doi.org/10.1055/a-0859-7168DOI Listing

Safety and Effectiveness of Ninjin'yoeito: A Utilization Study in Elderly Patients.

Front Nutr 2019 19;6:14. Epub 2019 Feb 19.

Kampo Research Laboratory, Kracie Pharma Ltd., Takaoka, Japan.

Post-marketing surveillance studies of traditional Japanese medicine in Japan are limited, and currently there are no data for Ninjin'yoeito, which is often used for the elderly because of its efficacy. In this study, we aimed to investigate the post-marketing safety and efficacy of Ninjin'yoeito in elderly patients over 65 years of age in clinical practice in Japan. This survey was an open-label, non-comparative, prospective, multicenter, post-marketing survey conducted at 383 centers between February 2016 and March 2017. Read More

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http://dx.doi.org/10.3389/fnut.2019.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401652PMC
February 2019

Disease Control With Delayed Salvage Radiotherapy for Macroscopic Local Recurrence Following Radical Prostatectomy.

Front Oncol 2019 28;9:12. Epub 2019 Feb 28.

Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

To retrospectively assess clinical outcomes and toxicity profile of prostate cancer patients treated with delayed dose-escalated image-guided salvage radiotherapy (SRT) for macroscopic local recurrence after radical prostatectomy (RP). We report on a cohort of 69 consecutive patients with local recurrence after RP and no evidence of regional or distant metastasis who were referred for salvage radiotherapy between 2007 and 2016. SRT consisted of 64-66 Gy (2 Gy/fraction) to the prostatic bed followed by dose escalation to 72-74 Gy (2Gy/fraction) to the macroscopic disease. Read More

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http://dx.doi.org/10.3389/fonc.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403145PMC
February 2019

Rare Complication of Botox Injection: A Case Report.

World J Plast Surg 2019 Jan;8(1):116-119

Department of Surgery, Iran University of Medical Science, Tehran, Iran.

Botulinum toxin (BTX) is also well-known as Botox is produced by a gram-positive anaerobic bacterium called Generally, clinical manifestations of BTX can be observed after consumption of contaminated food, from colonization of the infant gastrointestinal tract, as well as following the infection of the wound to this bacterium. There are seven types of this neurotoxin labeled as A, B, C (C1, C2), D, E, and F. Human botulinum is caused by types A, B, E and rarely F. Read More

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http://dx.doi.org/10.29252/wjps.8.1.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409137PMC
January 2019

Cola therapy for oesophageal food bolus impactions a case series.

Afr J Emerg Med 2019 Mar 13;9(1):41-44. Epub 2018 Oct 13.

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.

Introduction: This retrospective case series describes the use of cola to immediately treat complete oesophageal food bolus obstructions in the emergency centre. Short of emergent endoscopy - which is invasive, expensive, not without adverse events, and often unavailable in low-resource settings - no other proven therapies exist to relieve oesophageal food impactions.

Methods: We performed a chart review of adults with complete oesophageal food bolus obstructions presenting to two Dutch emergency centres. Read More

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http://dx.doi.org/10.1016/j.afjem.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399995PMC