361,716 results match your criteria Gastrointestinal Stromal Tumors


Surgery for Locally Advanced GIT Cancers Has Potentially Good Postoperative Outcomes in a Tertiary Hospital.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

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December 2018

Laparoscopic Roux-En-Y Fistulo-Jejunostomy, a Preferred Technique after Failure of Endoscopic and Radiologic Management of Fistula Post Sleeve Gastrectomy.

Obes Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Digestive Surgery, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint-Antoine, 06200, Nice, France.

Background: Laparoscopic sleeve gastrectomy represents the most performed bariatric procedure in France. Staple line leak is the major short-term complication of the procedure. Patients with persistent fistula after sleeve gastrectomy, after failure of endoscopic and radiological treatment, are candidates for salvage surgery. Read More

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December 2018

Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report.

Surg Case Rep 2018 Dec 13;4(1):144. Epub 2018 Dec 13.

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Gastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.

Case Presentation: An 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Read More

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December 2018

Contribution of IL-33 to the Pathogenesis of Colorectal Cancer.

Front Oncol 2018 28;8:561. Epub 2018 Nov 28.

Department of Gastroenterology, University Hospital of North Norway, Tromsø, Norway.

The development of colorectal cancer (CRC) is not only determined by transformed cells , but also by factors existing in their immune microenvironment. Accumulating scientific evidence has revealed that interleukin (IL)-33, an IL-1 family member, plays an essential role in the regulation of immune response and is relevant in CRC pathogenesis. Data from both human and experimental studies demonstrated that IL-33 inhibits host anti-tumor immunity, remodels tumor stroma and enhances angiogenesis, thereby promoting the development of CRC. Read More

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November 2018

Phase II Trial of Pure Hypofractionated Radiotherapy in the Treatment of Localized Carcinoma of the Prostate.

Cureus 2018 Oct 9;10(10):e3435. Epub 2018 Oct 9.

Radiation Oncology, Schulich School of Medicine & Dentistry - Western University, London, CAN.

Purpose To evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity and the biochemical control of pure hypofractionated radiotherapy (without acceleration) for the treatment of prostate cancer. Methods and materials This phase II prospective trial evaluated low-risk and intermediate-risk prostate cancer patients who received hypofractionated radiotherapy. Fifty-three patients with low-risk prostate cancer received 50 Gy in 15 fractions, 156 patients with intermediate-risk prostate cancer received 60 Gy in 20 fractions over eight weeks. Read More

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October 2018

Upper Gastrointestinal Bleed Embolization with Onyx: The "Tattoo Effect".

J Clin Imaging Sci 2018 15;8:46. Epub 2018 Nov 15.

Division of Gastroenterology and Hepatology, University of Kentucky, College of Medicine, Lexington, Kentucky, USA.

Endoscopic intervention is well validated for the control of upper gastrointestinal bleeding (UGIB). In cases of refractory bleeding, transarterial embolization is a safe and effective alternative. Ethylene vinyl alcohol (EVOH) commonly known as Onyx is an inherently black liquid embolic approved for use in cerebrovascular arteriovenous malformations and is increasingly used as an embolic agent in multiple peripheral and visceral territories. Read More

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November 2018

A well differentiated neuroendocrine tumor of the jejunum with peritoneal carcinomatosis: A case report.

Mol Clin Oncol 2018 Dec 4;9(6):651-655. Epub 2018 Oct 4.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Neuroendocrine tumors (NETs), belong to a group of neoplasms that arise from neuroendocrine cells and express markers such as synaptophysin and chromogranin A. The digestive system (DS) is the most common site of NET development. The World Health Organization classification divides NETs into low grade (G1-G2) tumors (NETs) and high grade carcinomas [neuroendocrine carcinomas (NECs)], based on mitotic index and histological criteria. Read More

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December 2018

Trabectedin in combination with pegylated liposomal doxorubicin in patients with ovarian tumors.

Mol Clin Oncol 2018 Dec 1;9(6):635-639. Epub 2018 Oct 1.

Department of Oncology, University of Florence, I-50134 Florence, Italy.

The majority of patients with ovarian cancer will experience relapse and thus require second-line therapy. While platinum-based therapies are the primary treatments for refractory disease other options are required, particularly for those with partially platinum-sensitive disease as their response rates are lower. Agents that can resensitize relapsed ovarian cancers to platinum, including trabectedin, are therefore of increasing interest. Read More

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December 2018

Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.

Biomed Rep 2018 Dec 18;9(6):511-516. Epub 2018 Oct 18.

Department of Physiology and Biochemistry, Princess Basma Teaching Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Previous studies have shown that progesterone could inhibit muscle contraction in various sites of the gastrointestinal tract. The underlying mechanisms responsible for these inhibitory effects of progesterone are not fully known. The aim of the current study was to investigate the effect of progesterone on the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway and muscle contraction in the stomach. Read More

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December 2018

Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells.

Oncol Lett 2018 Dec 28;16(6):7175-7179. Epub 2018 Sep 28.

Department of Gastrointestinal Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

This study investigated the role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Fifty-five patients with colon cancer who were treated in China-Japan Union Hospital of Jilin University from March 2014 to March 2015 were enrolled into this study. Their cancer and corresponding paracancerous tissues were collected and the expression levels of miR-214 were determined by RT-qPCR. Read More

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December 2018

High expression of class III β-tubulin in upper gastrointestinal cancer types.

Oncol Lett 2018 Dec 25;16(6):7139-7145. Epub 2018 Sep 25.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62. Read More

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December 2018

Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature.

Pathologica 2018 Sep;110(2):111-115

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology, Policlinico Universitario-Vittorio Emanuele, University of Catania, Italy.

Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma), extraneural perineurioma does occur, frequently involving the soft tissues of the lower and upper extremities, trunk and head and neck. Rarely it has also been reported in visceral organs, including gastrointestinal tract. Read More

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September 2018

The role of the microbiota in infectious diseases.

Nat Microbiol 2019 Jan 13;4(1):35-45. Epub 2018 Dec 13.

Department of Internal Medicine, Infectious Diseases Division, University of Michigan Medical School, Ann Arbor, MI, USA.

The human body is colonized by a diverse community of microorganisms collectively referred to as the microbiota. Here, we describe how the human microbiota influences susceptibility to infectious diseases using examples from the respiratory, gastrointestinal and female reproductive tract. We will discuss how interactions between the host, the indigenous microbiota and non-native microorganisms, including bacteria, viruses and fungi, can alter the outcome of infections. Read More

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January 2019

Pathologic Complete Response in a Large Gastric GIST: Using Molecular Markers to Achieve Maximal Response to Neoadjuvant Imatinib.

J Natl Compr Canc Netw 2018 Dec;16(12):1424-1428

Division of Surgical Oncology, Department of Surgical Pathology, Department of Medical Oncology, and Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Gastrointestinal stromal tumors (GISTs) represent 1% of alimentary tract neoplasms. Up to 90% of GISTs are driven by activating mutations in tyrosine kinase or α genes. Imatinib mesylate is a tyrosine kinase inhibitor that has recently been used in a neoadjuvant role for locally advanced GIST. Read More

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December 2018

A 17-Year-Old Boy With High-Functioning Autism, Gastrointestinal Illness, and Seizures.

Pediatrics 2018 Dec 13. Epub 2018 Dec 13.

Massachusetts General Hospital, Boston, Massachusetts; and

A healthy 17-year-old boy with a high-functioning pervasive developmental disorder presented to the emergency department after having a 4-minute episode of seizure-like activity in the setting of presumed viral gastroenteritis. Within an hour of emergency department arrival, he developed a forehead-sparing facial droop, right-sided ptosis, and expressive aphasia, prompting stroke team assessment and urgent neuroimaging. Laboratory results later revealed a serum sodium of 119 mmol/L. Read More

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December 2018
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Elective and emergent laparotomy closure: The importance of protocolizing the technique.

Cir Esp 2018 Dec 10. Epub 2018 Dec 10.

Cirugía de Pared Abdominal, Hospital Universitari Vall d'Hebron, Barcelona, España.

Background: Incisional hernias are a frequent complication, and their prevention includes proper closure of the abdominal wall.

Methods: A prospective study was conducted at a third-level hospital after the introduction of a midline laparotomy closure protocol. An objective measurement of the suture length to incision length ratio was made. Read More

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December 2018

Bevacizumab improves overall survival in platinum refractory ovarian cancer patients: A retrospective study.

Taiwan J Obstet Gynecol 2018 Dec;57(6):819-824

Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Saitama, Japan.

Objective: The objective of this study was to determine the effectiveness of bevacizumab (BV) in combination with chemotherapeutic regimens for prolonging progression-free survival (PFS) as well as overall survival (OS) in patients with platinum-refractory ovarian cancer.

Materials And Methods: We retrospectively reviewed the medical records of platinum-refractory ovarian cancer patients receiving chemotherapy between January 2010 and August 2015 in the Department of Gynecology at the Saitama Medical Center, Jichi Medical University. After excluding for prior malignant disease, 57 patients were enrolled. Read More

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December 2018

Perioperative surgery- and anaesthesia-related risks of laparoscopic Roux-en-Y gastric bypass - a single centre, retrospective data analysis.

BMC Anesthesiol 2018 Dec 13;18(1):190. Epub 2018 Dec 13.

Institute of Anaesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: Conservative obesity treatment often leads to limited results. Bariatric surgery is highly efficient, but the candidates are at risk of developing perioperative complications. Bariatric outcomes have been well described in the past, but there are only few reports of perioperative outcomes. Read More

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December 2018

[Irritable bowel syndrome: comorbid psychiatric disorders and psychological treatment options].

Orv Hetil 2018 Dec;159(50):2115-2121

Pszichológiai Intézet, Eötvös Loránd Tudományegyetem Budapest, Izabella u. 46., 1064.

Irritable bowel syndrome is a chronic functional gastrointestinal disorder with a prevalence of 7-21%. It has a negative impact on health-related quality of life and work productivity and it is associated with increased psychological distress and mental comorbidity, like major depression disorder and generalised anxiety disorder. Due to biopsychosocial factors and the brain-gut axis playing a key role in the aetiology of the disease, the use of psychological treatments has great importance in the therapy of irritable bowel syndrome. Read More

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December 2018

[Critically ill patient enteral nutrition in the 21st century].

Nutr Hosp 2018 Apr 3;0(0):27-33. Epub 2018 Apr 3.

.

In order to make estimations on the evolution and near future of enteral nutrition in critically ill adult patients, we have revised the current clinical practices based on the latest guidelines for the provision and assessment of enteral nutrition support therapy. Once revised the suggested guideline recommendations we proceed to discuss the major recently published studies concerning these guidelines. Finally, we commented on several uncertainty areas highlighting priorities for clinical research in the near future. Read More

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Influence of Gastrointestinal Flora in the Treatment of Cancer with Immune Checkpoint Inhibitors.

Authors:
L Mendoza

Klin Onkol 2018 ;31(6):465-467

The author declares he has no potential conflicts of interest concerning drugs, pro-ducts, or services used in the study. The Editorial Board declares that the manu-script met the ICMJE recommendation for biomedical papers. Submitted: 4. Read More

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January 2018

Isobaric Labeling Quantitative Metaproteomics for the Study of Gut Microbiome Response to Arsenic.

J Proteome Res 2018 Dec 14. Epub 2018 Dec 14.

Quantitative metaproteomics is a relatively new research field by applying proteomics technique to study microbial proteins of microbiome, and holds the great potential to truly quantify the functional proteins actually expressed by microbes in the biological environment such as gastrointestinal tract. The significant association between arsenic exposure and gut microbiome perturbations has been reported; however, metaproteomics has not yet been applied to study arsenic induced proteome changes of microbiome. Most importantly, to our knowledge, isobaric-labeling based large-scale metaproteomics has not been reported using the advanced database search approaches such as MetaPro-IQ and matched metagenome database search strategies to provide high quantification accuracy and less missing quantification values. Read More

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December 2018

Parechovirus A Detection by a Comprehensive Approach in a Clinical Laboratory.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.

Parechovirus A (Human parechovirus, HPeV) causes symptoms ranging from severe neonatal infection to mild gastrointestinal and respiratory disease. Use of molecular approaches with RT-PCR and genotyping has improved the detection rate of HPeV. Conventional methods, such as viral culture and immunofluorescence assay, together with molecular methods facilitate comprehensive viral diagnosis. Read More

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December 2018

Management of Typical and Atypical Pulmonary Carcinoids Based on Different Established Guidelines.

Cancers (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Division of Hematology & Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine, Buffalo, NY 14203, USA.

Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most common form of lung NETs, and other rare forms include well-differentiated typical carcinoids (TCs) and poorly differentiated atypical carcinoids (ACs). Read More

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December 2018

The Dietary Intervention of Transgenic Low-Gliadin Wheat Bread in Patients with Non-Celiac Gluten Sensitivity (NCGS) Showed No Differences with Gluten Free Diet (GFD) but Provides Better Gut Microbiota Profile.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

Departamento de Mejora Genética Vegetal, Instituto de Agricultura Sostenible (IAS-CSIC), 14004 Córdoba, Spain.

The study evaluated the symptoms, acceptance, and digestibility of bread made from transgenic low-gliadin wheat, in comparison with gluten free bread, in Non-coeliac gluten sensitivity (NCGS) patients, considering clinical/sensory parameters and gut microbiota composition. This study was performed in two phases of seven days each, comprising a basal phase with gluten free bread and an E82 phase with low-gliadin bread. Gastrointestinal clinical symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire, and stool samples were collected for gluten immunogenic peptides (GIP) determination and the extraction of gut microbial DNA. Read More

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December 2018

The Relationship between Infectious Diseases and Housing Maintenance in Indigenous Australian Households.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

School of Public Health, The University of Queensland, Brisbane 4006, Australia.

This research aimed to identify systemic housing-level contributions to infectious disease transmission for Indigenous Australians, in response to the Government program to 'close the gap' of health and other inequalities. A narrative literature review was performed in accordance to PRISMA guidelines. The findings revealed a lack of housing maintenance was associated with gastrointestinal infections, and skin-related diseases were associated with crowding. Read More

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December 2018

Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature.

Biomedicines 2018 Dec 11;6(4). Epub 2018 Dec 11.

Fondazione Novara Sviluppo, 28100 Novara, Italy.

The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria are capable of significantly influencing specific cells of the immune system, resulting in many diseases, including a neoplastic response. Read More

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December 2018
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Stimulating Respiratory Activity Primes Anaerobically Grown for Subsequent Intracellular Infections.

Pathogens 2018 Dec 8;7(4). Epub 2018 Dec 8.

Department of Biology, University of Dayton, Dayton, OH 45469, USA.

is a Gram-positive, enteric pathogen and the causative agent of listeriosis. During transition through the gastrointestinal tract, routinely encounters suboxic conditions. However, how the exposure to the low oxygen environment affects subsequent pathogenesis is not completely understood. Read More

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December 2018

Iron Supplements Containing 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures.

Nutrients 2018 Dec 8;10(12). Epub 2018 Dec 8.

Department of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.

Several human interventions have indicated that 299v ( 299v) increases intestinal iron absorption. The aim of the present study was to investigate possible effects of 299v on the mechanisms of iron absorption on the cellular level. We have previously shown that lactic fermentation of vegetables increased iron absorption in humans. Read More

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December 2018

Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Tianjin Key Lab of Radiation Medicine Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China.

Colorectal cancer is the most commonly reported gastrointestinal malignancy, with a recent, rapid increase of the annual incidence all over the world. Enhancing the radiosensitivity of cancer cells while preserving the health of normal cells is one of the most important tasks in clinical radiobiology. However, resistance to radiotherapy for colorectal cancer greatly decreases the therapeutic outcome. Read More

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December 2018

Protein Food Matrix⁻ZnO Nanoparticle Interactions Affect Protein Conformation, but May not Be Biological Responses.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Major of Food Science & Technology, Division of Applied Food System, Seoul Women's University, Seoul 01797, Korea.

Because of their nutritional value, zinc oxide (ZnO) nanoparticles (NPs) are applied as a dietary source of zinc, by direct addition to complex, multiple-component food matrices. The thereby occurring interactions of NPs with food matrices may have biological or toxic effects. In particular, NP interactions with food protein can lead to structural deformation of the latter, potentially changing its digestive efficiency and gastrointestinal absorption. Read More

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December 2018

Microbiome-The Missing Link in the Gut-Brain Axis: Focus on Its Role in Gastrointestinal and Mental Health.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.

The central nervous system (CNS) and the human gastrointestinal (GI) tract communicate through the gut-brain axis (GBA). Such communication is bi-directional and involves neuronal, endocrine, and immunological mechanisms. There is mounting data that gut microbiota is the source of a number of neuroactive and immunocompetent substances, which shape the structure and function of brain regions involved in the control of emotions, cognition, and physical activity. Read More

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December 2018

Ambient air pollution in gastrointestinal endoscopy unit; rationale and design of a prospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13600

Department of Internal Medicine.

Background: A gastrointestinal endoscopy unit is frequently exposed to gastrointestinal gas expelled from patients and electrocoagulated tissue through carbonation for the treatment of gastrointestinal neoplasms or hemostasis of gastrointestinal bleeding. This can be potentially harmful to the health of not only the healthcare personnel but also patients who undergo endoscopic examinations. However, there has been scarce data on air quality in the endoscopy unit. Read More

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December 2018

Pressure management as an occupational stress risk factor in irritable bowel syndrome: A cross-sectional study.

Medicine (Baltimore) 2018 Dec;97(49):e13562

Second Medical Department.

Irritable Bowel Syndrome (IBS) is the most prevalent functional gastrointestinal disorder. Psychosocial stress is one of the pathogenic factors involved in the pathogenesis of IBS. The Pressure Management Indicator (PMI) is a validated questionnaire to analyze all aspects of occupational stress-a model involving sources of pressure, the mechanisms of coping, the personality, and the resulting effects of the interaction between these 3 elements. Read More

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December 2018

Perforation of small intestine secondary to metastatic lung adenocarcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13469

Department of Emergency Surgery, Union Hospital.

Rationale: About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.

Patient Concerns: A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Read More

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December 2018

Hyponatremia: Prevalence and characteristics in internal medicine patients in southeast of China.

Medicine (Baltimore) 2018 Dec;97(49):e13389

Department of Endocrinology and Metabolism, The First Hospital of Jilin University.

To determine the incidence, clinical features, etiology, risk factors, and mortality in internal medicine patients with hyponatremia (P-Na).A prospective survey was conducted in patients with P-Na, diagnosed at admission in an Internal Medicine Department. 692 patients were then selected and subsequently divided into 3 groups based on the severity of P-Na. Read More

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December 2018

Survival nomograms for stage III colorectal cancer.

Medicine (Baltimore) 2018 Dec;97(49):e13239

Department of Gastrointestinal Surgery.

The postoperative survival of patients with stage III colorectal cancer (CRC) various obviously. We sought to develop novel nomograms for predicting the survival of these patients after radical surgery and postoperative chemotherapy.A total of 620 consecutive patients with stage III CRC who underwent curative resection and postoperative chemotherapy between January 2009 and December 2015 were retrospectively collected and randomly allocated to the training (n = 372) or validation cohort (n = 248). Read More

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December 2018

Secondary skin involvement in gastric diffuse large B-cell lymphoma treated with chidamide: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13093

Department of Hematology.

Rationale: Diffuse large B-cell lymphoma (DLBCL) is a neoplasm of large B lymphoid cells that exhibits diffuse growth patterns. Patients may present with nodal and/or extranodal disease. The most common extranodal site is the gastrointestinal tract, while skin is less common. Read More

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December 2018

Obesity and risk of urinary tract infection in young children presenting with fever.

Medicine (Baltimore) 2018 Dec;97(49):e13006

Department of Pediatrics, Tri-Service General Hospital, Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.

Obesity may increase the risk of infection, but the association between obesity and febrile urinary tract infection (fUTI) is controversial. Although the prevalence of infant and childhood obesity has been increasing worldwide, the results of previous investigations on the association with urinary tract infection (UTI) are conflicting. The purpose of this study was to evaluate the relationship between overweight and obesity and UTI in febrile children. Read More

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December 2018

Prognostic grading system specifically for elderly patients with brain metastases after stereotactic radiosurgery: a 2-institution study.

Authors:

J Neurosurg 2018 Dec;129(Suppl1):95-102

OBJECTIVEWith the aging of the population, increasing numbers of elderly patients with brain metastasis (BM) are undergoing stereotactic radiosurgery (SRS). Among recently reported prognostic grading indexes, only the basic score for brain metastases (BSBM) is applicable to patients 65 years or older. However, the major weakness of this system is that no BM-related factors are graded. Read More

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December 2018

Optical diagnosis expanded to small polyps: post-hoc analysis of diagnostic performance in a prospective multicenter study.

Endoscopy 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Background: Optical diagnosis can replace histopathology of diminutive (1 - 5 mm) polyps if surveillance intervals based on optical diagnosis of polyps have ≥ 90 % agreement with intervals based on polyp histology and if the negative predictive value (NPV) for predicting neoplastic histology in the rectosigmoid is ≥ 90 %. This study aims to assess whether small (6 - 9 mm) polyps can be included in optical diagnosis strategies.

Method: This is a post-hoc analysis of a prospective multicenter study in which 27 endoscopists, all performing endoscopies for the Dutch screening program, were trained in optical diagnosis. Read More

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December 2018

Nintedanib in Idiopathic Pulmonary Fibrosis: Practical Management Recommendations for Potential Adverse Events.

Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.

Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More

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December 2018

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy.

Eur J Cancer 2018 Dec 10;107:60-67. Epub 2018 Dec 10.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

Background: Fluoropyrimidine therapy including capecitabine or 5-fluorouracil can result in severe treatment-related toxicity in up to 30% of patients. Toxicity is often related to reduced activity of dihydropyrimidine dehydrogenase, the main metabolic fluoropyrimidine enzyme, primarily caused by genetic DPYD polymorphisms. In a large prospective study, it was concluded that upfront DPYD-guided dose individualisation is able to improve safety of fluoropyrimidine-based therapy. Read More

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December 2018

Intravenous Immunoglobulin (IVIG) in the vanguard therapy of Systemic Sclerosis.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Sackler Faculty of Medicine, Tel Aviv University, Israel; Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel. Electronic address:

Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by a progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition, which lead to a multisystemic dysfunction. Various pathogenetic mechanisms were described. The lack of a successful therapy make SSc a disease with a poor prognosis. Read More

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December 2018

The loss of tolerance to CHI3L1 - A putative role in inflammatory bowel disease?

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Institute for Biotechnology, Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Universitätsplatz 1, 01968 Senftenberg, Germany. Electronic address:

The incidence of inflammatory bowel disease (IBD) is steadily increasing. IBD is characterized by a chronic inflammation of the gastrointestinal tract and is classified into the two main groups Crohn's disease (CD) and ulcerative colitis (UC). Genetic predispositions, environmental factors and a dysregulated immune response are known to part take in the onset of IBD. Read More

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December 2018

Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies.

J Allergy Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, MD. Electronic address:

Background: Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is selectively expressed on eosinophils, mast cells and basophils, and, when engaged on eosinophils, can cause cell death.

Objective: To characterize surface and soluble Siglec-8 levels in normal (ND) and eosinophilic (EO) subjects and assess the efficacy of anti-Siglec-8 antibodies in inducing eosinophil cell death in vitro.

Methods: Eosinophil expression of Siglec-8 was assessed using flow cytometry and quantitative PCR. Read More

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December 2018

Anti-cholinergics mecamylamine and scopolamine alleviate motion sickness-induced gastrointestinal symptoms through both peripheral and central actions.

Neuropharmacology 2018 Dec 10. Epub 2018 Dec 10.

Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China. Electronic address:

Enhanced cholinergic activity contributes to the production of complex autonomic manifestations of motion sickness (MS). However, whether anti-cholinergics exert their anti-MS effects through central or peripheral actions remained unclarified. In the present study, we investigated the effects of mecamylamine (MEC) and scopolamine (SCOP) on rotation-induced gastrointestinal symptoms (conditioned gaping and defecation), locomotion disturbances (hypoactivity and impaired balance performance), hypothermia as well as Fos expression in vestibulo-autonomic regions in rats. Read More

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December 2018

Bayesian adjustment for trend of colorectal cancer incidence in misclassified registering across Iranian provinces.

PLoS One 2018 13;13(12):e0199273. Epub 2018 Dec 13.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Misclassification error is a common problem of cancer registries in developing countries that leads to biased cancer rates. The purpose of this research is to use Bayesian method for correcting misclassification in registered cancer incidence of eighteen provinces in Iran. Incidence data of patients with colorectal cancer were extracted from Iranian annual of national cancer registration reports from 2005 to 2008. Read More

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December 2018

Microbiome and disease in the upper airway.

Curr Opin Allergy Clin Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Head and Neck Surgery, University of Colorado Medical Center, Denver, California, USA.

Purpose Of Review: Microbiome refers to the genetic potential of resident microorganisms that inhabit a given niche. The exact role of the microbiome and its relation to chronic disease processes remains largely unknown, although various associations have been observed. We reviewed current literature investigating the microbiome of the upper airway by subsite (nasal cavity, sinus cavities, nasopharynx, and larynx) and its relation to chronic inflammatory disease processes. Read More

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December 2018