452,478 results match your criteria Gastrointestinal Neoplasms

Carcinoid ovary with synchronous carcinoid tumour of the appendix: report of a rare occurrence with review of literature.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Gynaecologic Oncology, Dr B Borooah Cancer Society Trust, Guwahati, Assam, India.

Carcinoid tumours are present in a wide range of organs but most frequently involve the gastrointestinal tract and rarely reported in gynaecological organs. Literature reports that the prevalence of ovarian carcinoid is 0.3%-1% of ovarian neoplasms and accounts for only 5% of ovarian teratomas. Read More

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Neuroendocrine tumor of the ampulla of Vater. Rreview of the literature.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Sección de Aparato Digestivo, Hospital General Universitario Reina Sofía, España.

Neuroendocrine tumors (NETs) or carcinoids represent a small percentage of gastrointestinal neoplasms (2%). The ileum (41.8%), rectum (27. Read More

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Epigenetic Regulation in Gastroenteropancreatic Neuroendocrine Tumors.

Judy S Crabtree

Front Oncol 2022 7;12:901435. Epub 2022 Jun 7.

Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

Gastroenteropancreatic neuroendocrine neoplasms are a rare, diverse group of neuroendocrine tumors that form in the pancreatic and gastrointestinal tract, and often present with side effects due to hormone hypersecretion. The pathogenesis of these tumors is known to be linked to several genetic disorders, but sporadic tumors occur due to dysregulation of additional genes that regulate proliferation and metastasis, but also the epigenome. Epigenetic regulation in these tumors includes DNA methylation, chromatin remodeling and regulation by noncoding RNAs. Read More

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High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer.

J Clin Med 2022 Jun 20;11(12). Epub 2022 Jun 20.

Division of Gastroenterology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.

Claudin (CLDN) is a tight junction protein found in human epithelial cells and its altered expression is known to be associated with the progression of gastric cancer. We aimed to investigate the differential expression of CLDN-4 in early gastric cancer (EGC) according to its clinicopathological characteristics. We enrolled 53 patients with EGC who underwent surgical gastric resection from January 2007 to December 2018. Read More

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Treatment of Gastrointestinal Stromal Tumors (GISTs): A Focus on Younger Patients.

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.

Gastrointestinal stromal tumors (GISTs) originate from Cajal's cells and are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs in young adults, i.e. Read More

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Enhancer of Zeste Homolog 2 (EZH2) Is a Marker of High-Grade Neuroendocrine Neoplasia in Gastroenteropancreatic and Pulmonary Tract and Predicts Poor Prognosis.

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Institute of Pathology, University Medical Center Goettingen, Georg-August-University, 37075 Goettingen, Germany.

Tumor grading is a robust prognostic predictor in patients with neuroendocrine neoplasms (NEN) and guides therapy, especially in tumors with high proliferation. NEN can be separated into well-differentiated and poorly differentiated types. The more aggressive NEN have been further separated into neuroendocrine tumors (NET G3) with a better prognosis and neuroendocrine carcinomas (NEC) with a worse prognosis. Read More

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Presence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study.

Infect Agent Cancer 2022 Jun 23;17(1):35. Epub 2022 Jun 23.

Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge, 2, 56124, Pisa, Italy.

The mouse mammary tumour virus (MMTV) is implicated in the aetiology of murine mammary carcinomas and a variant of it, the type B leukemogenic virus, can cause murine thymic lymphomas. Interestingly, a MMTV-like virus is suspected to be involved in human breast cancer and feline mammary carcinomas. However, to date, no cases of MMTV-like sequence amplifications have been described in lymphoid neoplasms in veterinary literature. Read More

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Prognostic prediction of preoperative nutritional status in low-grade appendiceal mucinous neoplasms.

Sci Rep 2022 Jun 23;12(1):10678. Epub 2022 Jun 23.

Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China.

To describe the preoperative nutritional status of Low-grade Appendiceal Mucinous Neoplasms (LAMNs) and identify prognostic factors for survival. Medical records from 165 patients with LAMNs who attended the Aerospace Center Hospital, Beijing, China between January 2017, and December 2018 were retrospectively reviewed. Survival analysis was performed with the Kaplan-Meier method, the log-rank test, and a Cox proportional hazards model. Read More

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[Influence of smoking on the gastrointestinal tract : Range of findings].

Radiologie (Heidelb) 2022 Jun 23. Epub 2022 Jun 23.

Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Background: Nicotine is a highly addictive drug that, if consumed regularly, can result in chronic or incurable diseases and a reduced quality of life.

Objectives: The aim of this review is to describe the possible health consequences of smoking on the gastrointestinal tract and to provide an overview of related neoplastic and nonneoplastic gastrointestinal diseases.

Materials And Methods: Based on an extensive literature review, the current knowledge about smoker-associated diseases of the gastrointestinal tract is summarized. Read More

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Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients.

Tomography 2022 Jun 9;8(3):1503-1508. Epub 2022 Jun 9.

Department of Neurology, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea.

Cognitive impairment in cancer patients can be caused by various factors; in approximately 30% of cancer patients, the symptoms appear before starting treatment. Paraneoplastic limbic encephalitis (PLE) is a rare disease associated with an autoimmune response, and is characterized by memory loss, depression, and personality changes; it is one of the potential causes of cognitive dysfunction in cancer patients. Two patients were previously diagnosed with mild cognitive impairment and maintained clinical stability; after suffering a rapid change in personality and sudden cognitive decline, colorectal cancer was diagnosed within a few months. Read More

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Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis.

Biosensors (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Mechanical Engineering, Advanced Institute of Manufacturing with High Tech Innovations (AIM-HI), Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi 62102, Taiwan.

In this study, a biochip was fabricated using a light-absorbing layer of a silicon solar element combined with serrated, interdigitated electrodes and used to identify four different types of cancer cells: CE81T esophageal cancer, OE21 esophageal cancer, A549 lung adenocarcinoma, and TSGH-8301 bladder cancer cells. A string of pearls was formed from dielectrophoretic aggregated cancer cells because of the serrated interdigitated electrodes. Thus, cancer cells were identified in different parts, and electron-hole pairs were separated by photo-excited carriers through the light-absorbing layer of the solar element. Read More

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Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients.

Curr Oncol 2022 Jun 7;29(6):4138-4147. Epub 2022 Jun 7.

Department of Pediatric Oncology, Faculty of Medicine, University Hospital Brno and Masaryk University, Cernopolni 9, 613 00 Brno, Czech Republic.

Sunitinib is a broad-spectrum multitargeted tyrosine kinase inhibitor mainly used as second-line therapy for non-resectable gastrointestinal stromal or first-line treatment option of metastatic renal cell carcinoma (mRCC), and as an "off-label" option in pediatric oncology. It has been previously reported that sunitinib elevates the mean corpuscular volume of erythrocytes (MCV) in treated subjects. The aim of this study was to assess time-dependent changes of this effect and evaluate its possible clinical relevance. Read More

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Antiangiogenic Drug-Induced Proteinuria as a Prognostic Factor in Metastatic Colorectal Cancer.

Curr Oncol 2022 May 31;29(6):3996-4011. Epub 2022 May 31.

Immunology Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Treatment with bevacizumab is known to cause adverse events such as proteinuria and hypertension, amongst others. However, while bevacizumab-induced hypertension has been linked to increased overall survival (OS), data on proteinuria are controversial. We performed a retrospective analysis to observe the influence of adverse events developed during treatment with bevacizumab and chemotherapy on the OS in patients with metastatic colorectal cancer (mCRC). Read More

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[Neutropenic enterocolitis in the pediatric cancer patient].

Rev Chilena Infectol 2022 02;39(1):59-69

Hospital Clínico San Borja Arriarán, Chile.

Neutropenic enterocolitis (NEC) is a heterogeneous disease of the gastrointestinal tract with systemic response, that corresponds to a severe and life-threatening clinical condition in immunocompromised patients, especially in childhood cancer. The pathologic features are poorly understood, although its multifactorial cause of NEC is well established and it is associated with the cytotoxic effects of the chemotherapy agents used and recognized by the classic triad of fever, neutropenia, and abdominal pain, secondary to gastrointestinal injuries that alters mucosal permeability and helps intramural bacterial invasion. NEC is truly a clinical challenge that requires an early diagnosis and a multidisciplinary approach including basic laboratory and imagological tests in high complexity centers. Read More

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February 2022

Lipid metabolism-related lncRNA SLC25A21-AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c-Myc axis and SLC25A21 expression.

Clin Transl Med 2022 Jun;12(6):e944

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Obesity alters metabolic microenvironment and is thus associated with several tumours. The aim of the present study was to investigate the role, molecular mechanism of action, and potential clinical value of lipid metabolism-related long non-coding RNA (lncRNA) SLC25A21-AS1 in oesophageal squamous cell carcinoma (ESCC).

Methods: A high-fat diets (HFDs)-induced obesity nude mouse model was established, and targeted metabolomics analysis was used to identify critical medium-long chain fatty acids influencing the growth of ESCC cells. Read More

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Prevalence of Epstein-Barr Virus Infection and Mismatch Repair Protein Deficiency and the Correlation of Immune Markers in Tibetan Patients with Gastric Cancer.

Biomed Res Int 2022 13;2022:2684065. Epub 2022 Jun 13.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Gastric cancer (GC) is a major cause of cancer-related death in China. Immunotherapies based on PD-1/PD-L1 inhibitors have improved the survival of some patients with GC. Epstein-Barr virus (EBV) infection, mismatch repair (MMR) deficiency, and tumor immune microenvironment (TIME) markers (such as CD3, CD8, and PD-L1) may help to identify specific patients who will respond to PD-1/PD-L1 inhibitors. Read More

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Application of Half-Transected and Self-Pulling Esophagojejunostomy in Total Laparoscopic Gastrectomy for Gastric Cancer: A Safe and Feasible Technique.

Can J Gastroenterol Hepatol 2022 13;2022:2422274. Epub 2022 Jun 13.

Jiangxi Province Cancer Hospital, Nanchang, Jiangxi, China.

Objective: This study introduces a technique for esophagojejunostomy with half transected and self-pulling (HTSP) and evaluates the safety, feasibility, and clinical results of this technique in totally laparoscopic total gastrectomy (TLTG).

Materials And Methods: From May 2019 to March 2021, 42 patients (HTSP group) who underwent HTSP-TLTG surgery in the Department of Abdominal Tumor Surgery of Jiangxi Cancer Hospital were included in this study. The control group consisted of 50 patients undergoing conventional TLTG surgery (conventional anastomosis group) performed by the same surgical team from March 2018 to March 2020. Read More

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The Modified Glasgow Prognostic Score Predicts Survival in Gastric Cancer Patients with Normal CEA and CA19-9.

Can J Gastroenterol Hepatol 2022 13;2022:3953004. Epub 2022 Jun 13.

Department of Gastrointestinal Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.

Background: Traditionally, serum CEA and CA19-9 levels are good prognostic factors for gastric cancer. Many gastric cancer patients do not have elevated CEA or CA19-9 levels even at a very advanced stage. This study investigates the significance of the modified Glasgow prognostic score (mGPS) for the survival of gastric cancer patients with normal CEA and CA19-9. Read More

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Long-term outcomes after extra-levator versus conventional abdominoperineal excision for low rectal cancer.

BMC Surg 2022 Jun 22;22(1):242. Epub 2022 Jun 22.

Department of General Surgery, Beijing Chaoyang Hosptial, Capital Medical University, No. 8 Gongtinan Lu, Chaoyang District, Beijing, People's Republic of China.

Purpose: Extralevator (ELAPE) and abdominoperineal excision (APE) are two major surgical approaches for low rectal cancer patients. Although excellent short-term efficacy is achieved in patients undergoing ELAPE, the long-term benefits have not been established. In this study we evaluated the safety, pathological and survival outcomes in rectal cancer patients who underwent ELAPE and APE. Read More

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miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer.

BMC Cancer 2022 Jun 22;22(1):689. Epub 2022 Jun 22.

Ningbo Medical Centre Lihui Li Eastern Hospital, Ningbo University, Jiangnan Road No.1111, Ningbo, 330212, Zhejiang, China.

Background: The mechanism of long non-coding RNA MIR137HG in human gastric cancer (GC) is currently unknown. In the present study, we aimed to explore the function and mechanism of MIR137HG in gastric cancer.

Methods: The expression of lncRNA-MIR137HG in 69 gastric cancer samples and their paired surgical margin (SM) tissue samples were tested by QRT-PCR. Read More

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Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis.

BMC Genom Data 2022 Jun 22;23(1):48. Epub 2022 Jun 22.

Department of Oncology, Jining Hospital of Traditional Chinese Medicine, 3 Huancheng North Road, Jining, 272000, Shandong Province, China.

Background: Colitis-associated colon cancer (CAC) patients have a younger age of onset, more multiple lesions and invasive tumors than sporadic colon cancer patients. Early detection of CAC using endoscopy is challenging, and the incidence of septal colon cancer remains high. Therefore, identifying biomarkers that can predict the tumorigenesis of CAC is in urgent need. Read More

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Comparison of the gastric microbiome in Billroth I and Roux-en-Y reconstructions after distal gastrectomy.

Sci Rep 2022 Jun 22;12(1):10594. Epub 2022 Jun 22.

Department of General and Gastroenterological Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

The changes in gastric microbiota following reconstruction after gastrectomy have not been reported. This study aimed to compare the gastric microbiota following Billroth I and Roux-en-Y reconstructions after distal gastrectomy. We enrolled 71 gastrectomized patients with gastric cancer; 31 and 40 underwent Billroth I and Roux-en-Y reconstructions, respectively. Read More

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Facile preparation of aqueous-soluble fluorescent polyethylene glycol functionalized carbon dots from palm waste by one-pot hydrothermal carbonization for colon cancer nanotheranostics.

Sci Rep 2022 Jun 22;12(1):10550. Epub 2022 Jun 22.

Department of Chemical Engineering, Faculty of Engineering, Mahidol University, 999 Putthamonthon 4 Road, Salaya, Putthamonthon, 73170, Nakorn Pathom, Thailand.

Carbon dots (CDs) are categorized as an emerging class of zero-dimension nanomaterials having high biocompatibility, photoluminescence, tunable surface, and hydrophilic property. CDs, therefore, are currently of interest for bio-imaging and nano-medicine applications. In this work, polyethylene glycol functionalized CDs (CD-PEG) were prepared from oil palm empty fruit bunch by a one-pot hydrothermal technique. Read More

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ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.

Cell Death Dis 2022 Jun 22;13(6):564. Epub 2022 Jun 22.

State Key Laboratory of Silkworm Genome Biology, Southwest University, 400716, Chongqing, China.

Ariadne homolog 2 (ARIH2) is a key member of the RING-between-RING (RBR) E3 ligase family, which is characterized by an RBR domain involved in the polyubiquitination process. However, the molecular mechanism and biological function of ARIH2 in the pathogenesis of gastric cancer remain unclear. In this paper, we found that high ARIH2 expression is correlated with poor prognosis in gastric cancer patients and that ARIH2 can significantly promote the proliferation of gastric cancer cells. Read More

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[Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):513-521

Cancer Research Center/Key Laboratory of the Science and Technology Department of Jilin Province, Yanbian University, Department of Pathology, Medical College of Yanbian University, Yanji 133002, China. *Corresponding author, E-mail:

Objective To explore the inhibitory effect of cordycepin on the proliferation and migration of gastric cancer cells and its molecular mechanism. Methods MGC-803 cells were treated with 0, 25, 50, 100 μmol/L of cordycepin and HGC-27 cells with 0, 5, 25, 50 μmol/L of cordycepin for 48 hours. The proliferation ability of MGC-803 and HGC-27 cells was detected by MTT assay and EdU assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of MGC-803 and HGC-27 cells; the chromatin agglutination was detected by Hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin V-FITC/PI double labeling combined with flow cytometry; Western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (SREBF1), fatty acid synthase (FASN), and acetyl coA carboxylase 1 (ACC1), epithelial-mesenchymal transition (EMT)-related proteins including E-cadherin, vimentin, Snail, Slug, matrix metalloproteinase 2 (MMP2), MMP9, AMPK, and phosphorylated AMPK (p-AMPK), MAPK signaling pathway-related proteins including JNK, phosphorylated JNK (p-JNK), p38 MAPK, and p-p38 MAPK, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (ADP-ribose) polymerase (c-PARP). Read More

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[Over-expression of NUDT21 inhibits the proliferation of HCT-116 colon cancer cells via blocking P53/CDK2/Rb pathway].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):507-512

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China. *Corresponding authors, E-mail:

Objective To investigate the effect of over-expression of nudix hydrolase 21 (NUDT21) on the proliferation of colon cancer HCT-116 cells and its mechanism. Methods The NUDT21 over-expression plasmid was constructed by Gibson assembly. The colony formation assay and CCK-8 assay were used to detect cell proliferation. Read More

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[miR-328-3p down-regulates FOXP3 to inhibit IL-17-induced invasion and migration of Caco-2 human colorectal cancer cells].

Weili Zhang

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):487-493

School of Medicine, Xinyang Vocational and Technical College, Xinyang 464000, China. *Corresponding author, E-mail:

Objective To investigate the effect of miR-328-3p on the invasion and migration of colorectal cancer cells induced by interleukin-17 (IL-17) and its mechanism. Methods Real-time quantitative PCR was used to detect the expressions of miR-328-3p, FOXP3, and IL-17 mRNA in FHC colorectal epithelial cells and colorectal cancer cells (HCT116, Caco-2, and LoVo). Transwell assay was used to detect cell invasion and migration, and gelatin zymography assay to detect the activities of matrix metalloproteinases 2 (MMP2) and MMP9. Read More

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Laparoscopic versus open left hemicolectomy for left-sided colon cancer: protocol for a systematic review and meta-analysis.

BMJ Open 2022 Jun 22;12(6):e062216. Epub 2022 Jun 22.

Department of Gastrointestinal Surgery, Sichuan University West China Hospital, Chengdu, Sichuan, China

Introduction: Laparoscopic colectomy has been widely used clinically due to its minimally invasive advantages, and many studies have also demonstrated its safety and efficacy. However, the efficacy of laparoscopic left hemicolectomy remains unclear due to the differences in pathogenesis and surgical details between left and right colon cancers. Therefore, we plan to conduct a systematic review and meta-analysis to investigate whether laparoscopic techniques can be safely used in left hemicolectomy. Read More

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Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis.

BMJ Open 2022 Jun 22;12(6):e052373. Epub 2022 Jun 22.

General Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China

Objective: Investigative studies report contradictory results of the relationship between serum lipid levels and the risk of colorectal cancer (CRC). We conducted a meta-analysis of prospective published studies to clarify the relationship between serum lipid and CRC risk.

Design: Systematic review and meta-analysis. Read More

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Vaccines for immunoprevention of DNA mismatch repair deficient cancers.

J Immunother Cancer 2022 Jun;10(6)

University Hospital Heidelberg, Institute of Pathology, Department of Applied Tumor Biology, Heidelberg, Germany.

The development of cancer vaccines to induce tumor-antigen specific immune responses was sparked by the identification of antigens specific to or overexpressed in cancer cells. However, weak immunogenicity and the mutational heterogeneity in many cancers have dampened cancer vaccine successes. With increasing information about mutational landscapes of cancers, mutational neoantigens can be predicted computationally to elicit strong immune responses by CD8 +cytotoxic T cells as major mediators of anticancer immune response. Read More

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