381,124 results match your criteria Gastrointestinal Neoplasms


Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors.

Diagn Cytopathol 2018 Aug;46(8):663-669

Department of Pathology and Laboratory Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.

Background: Spindle cell neoplasms of the gastrointestinal (GI) tract constitute a wide group of lesions that may raise diagnostic difficulties on hematoxylin-eosin-stained slides. Appropriate endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) technique with sufficient cell block material for immunohistochemistry (IHC) can lead to accurate diagnosis.

Methods: This is a retrospective study of 29 cases obtained from our institution's records over a five-year period (2011-2015). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dc.23976DOI Listing

Novel Circulating miRNA Signatures for Early Detection of Pancreatic Neoplasia.

Clin Transl Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)/Hospital Clínic of Barcelona/Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) presents the lowest survival rate of all cancers because only 6% of patients reach five-year survival. Alterations in the expression of several microRNAs (miRNAs) occur in the tumor of PDAC and in preneoplastic lesions as the called intraductal papillary mucinous neoplasm (IPMN). Here, we aimed at identifying which miRNAs are significantly altered in liquid biopsies from patients with PDAC and IPMN to find new noninvasive biomarkers for early detection of PDAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14309/ctg.0000000000000029DOI Listing

Cecal Mucosal Myxoma: The First Report of a New Type of Mesenchymal Colon Polyp.

Int J Surg Pathol 2019 Apr 22:1066896919843625. Epub 2019 Apr 22.

1 University of Rochester, Rochester, NY, USA.

Myxomas are benign mesenchymal neoplasms of unknown etiology that most commonly occur in the cardiac atrium; however, other reported sites include the skin, joints, skeletal muscles, maxillofacial bones, and sinonasal tract. Myxomas involving the gastrointestinal (GI) tract are rare and are limited to a few published case reports. We are presenting, to our knowledge, the first case report of a mucosal myxoma in the colon presenting as a colonic polyp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1066896919843625DOI Listing

Where is the finish line for endoscopic eradication therapy in Barrett's esophagus?

Gastrointest Endosc 2019 05;89(5):926-928

Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2019.01.017DOI Listing
May 2019
1 Read

MDM2 copy number increase: A poor prognostic, molecular event in esophageal squamous cell carcinoma.

Hum Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; Institute of Liver Studies, King's College Hospital, London, UK. Electronic address:

The present study aimed to elucidate the clinicopathological significance of molecular alterations in MDM2 in esophageal squamous cell carcinoma (ESCC). A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization (DISH) for MDM2 and immunohistochemistry for p53 using tissue microarrays. Clinicopathological features were correlated with the MDM2 status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2019.04.002DOI Listing

Pancreaticobiliary metastasis presenting as primary mucinous ovarian neoplasm: A systematic literature review.

Gynecol Oncol Rep 2019 May 27;28:109-115. Epub 2019 Mar 27.

Temple University Hospital, Department of Obstetrics, Gynecology, and Reproductive Sciences, 3401 North Broad Street, Philadelphia, PA 19140, United States of America.

True primary mucinous ovarian carcinomas are rarer than originally thought and their clinical behavior and treatment response are different than more common epithelial ovarian carcinomas. Secondary ovarian neoplasms often mimic the clinical and histological features of mucinous ovarian cancer making their diagnosis, and therefore treatment, more difficult. Misdiagnosis can have a significant impact on both treatment and prognosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23525789193003
Publisher Site
http://dx.doi.org/10.1016/j.gore.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453658PMC
May 2019
1 Read

Management of adverse events related to endoscopic resection of esophageal and gastric neoplasms: Report of consensus meeting.

Dig Endosc 2019 Apr;31 Suppl 1:2-3

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/den.13386DOI Listing
April 2019
1 Read

Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.

Dig Endosc 2019 Apr;31 Suppl 1:4-20

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Prevention therapy is recommended for lesions >1/2 of the esophageal circumference. Locoregional steroid injection is recommended for lesions >1/2-3/4 of the esophageal circumference and oral steroids are recommended for lesions >1/2 of the subtotal circumference. For lesions of the entire circumference, oral steroid combined with injection steroid is considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/den.13388DOI Listing
April 2019
2 Reads

Comparison of two methods for endoscopic full-thickness resection of gastrointestinal lesions using OTSC.

Minim Invasive Ther Allied Technol 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Gastroenterology , Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases , Beijing , China.

Background And Aims: The aim of this study was to compare and analyze the feasibility and safety of two methods of endoscopic full-thickness resection (EFTR) for the management of challenging epithelial and subepithelial neoplasms that are not amenable to resection techniques.

Material And Methods: This was a retrospective case series study of patients who underwent one of two methods of EFTR, resection using ESD knives and post-resection closure with OTSC (Group 1), or closure with OTSC and secondary EFTR with snare (Group 2).

Results: Of 11 patients, six were in Group 1 and five in Group 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13645706.2019.1602544DOI Listing
April 2019
2 Reads

Solitary adrenal metastasis from advanced gastric cancer invading duodenal bulb with situs inversus totalis: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15244

Department of the General Surgery.

Rationale: Situs invsersus totalis (SIT) is a rare anomaly featured by complete inversion of abdominal and thoracic organs. Adrenal metastasis is often encountered as part of advanced systemic dissemination, which is usually unresectable. Few published cases reported the adrenal metastasis from gastric cancer with SIT and the treatment of gastrectomy combined with adrenalectomy, especially with intraoperative radiotherapy (IORT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015244DOI Listing
April 2019
1 Read

MicroRNA-related transcription factor regulatory networks in human colorectal cancer.

Medicine (Baltimore) 2019 Apr;98(15):e15158

Department of Medical Research Center.

Objective: Colorectal cancer (CRC) is an extremely common gastrointestinal malignancy. The present study aimed to identify microRNAs (miRNAs) and transcription factors (TFs) associated with tumor development.

Methods: Three miRNA profile datasets were integrated and analyzed to elucidate the potential key candidate miRNAs in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015158DOI Listing
April 2019
3 Reads

Factors predicting the colorectal adenoma detection rate in colonoscopic screening of a Chinese population: A prospective study.

Medicine (Baltimore) 2019 Apr;98(15):e15103

Department of Gastroenterology and Hepatology.

Colorectal cancer has high incidence and mortality. Early diagnosis could increase patient survival, but early diagnosis has been poor in China for the past decades. The purpose of this study is to assess the polyp detection rate (PDR) and adenoma detection rate (ADR) by colonoscopy in a Chinese population, and to determine the risk factors for adenoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015103DOI Listing
April 2019
1 Read

ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Colorectal cancer (CRC) is one of the most common malignant neoplasms with high mortality worldwide. Oridonin, a diterpenoid isolated from the Chinese medicinal herb Rabdosia rubescens, has been proved to have anticancer effect on various types of cancer cells. However, the detailed mechanisms of oridonin in CRC cells remain unclear and if oridonin can overcome 5-FU resistance have not been investigated yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.04.011DOI Listing
April 2019
1 Read

Patient-reported health problems and healthcare use after treatment for early-stage breast cancer.

Breast 2019 Apr 4;46:4-11. Epub 2019 Apr 4.

Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands; Department of Health Technology and Services Research, Faculty of Behavioural, Management and Social Sciences, Technical Medical Centre, University of Twente, Enschede, the Netherlands.

Background: A clear picture of treatment-related health problems following breast cancer treatment is useful in anticipating the informational and other needs of patients during follow-up. This study aimed to identify treatment-related health problems in breast cancer patients up to five years after diagnosis. Secondly, the use of care associated with these health problems was identified. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09609776193047
Publisher Site
http://dx.doi.org/10.1016/j.breast.2019.03.010DOI Listing
April 2019
3 Reads

Can acetylcysteine ameliorate cisplatin-induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double-blind, placebo-controlled trial involving patients with head and neck cancer.

Cancer Med 2019 Apr 11. Epub 2019 Apr 11.

Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil.

The protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental models; however, its efficacy in patients has not been elucidated. The aim of this study was to investigate the possible protective effect of NAC on cisplatin-induced toxicity and the effect of NAC on clinical response and oxidative stress in patients treated for head and neck cancer. This was a randomized, double-blind, placebo-controlled trial conducted in patients receiving high-dose cisplatin chemotherapy concomitant to radiotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.2072DOI Listing
April 2019
1 Read

Association of expression of inflammatory response genes and DNA repair genes in colorectal carcinoma.

Tumour Biol 2019 Apr;42(4):1010428319843042

1 Department of Surgery, São Paulo State Civil Servant Hospital, São Paulo, Brazil.

Inflammation is an important etiological factor of colorectal carcinoma and may be related to colorectal carcinoma growth and proliferation. This study aimed to verify whether the presence of chronic inflammation represented by tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-10 gene expression is related to hMLH1, hMSH2, hMSH6, and PMS2 gene expression and the corresponding protein levels of these genes from the DNA repair system. A total of 83 patients were operated on for curative or palliative colorectal carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1010428319843042DOI Listing

Estimating the Survival of Patients With Lung Cancer: What Is the Best Statistical Model?

J Prev Med Public Health 2019 Mar 18;52(2):140-144. Epub 2019 Feb 18.

Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Objectives: Investigating the survival of patients with cancer is vitally necessary for controlling the disease and for assessing treatment methods. This study aimed to compare various statistical models of survival and to determine the survival rate and its related factors among patients suffering from lung cancer.

Methods: In this retrospective cohort, the cumulative survival rate, median survival time, and factors associated with the survival of lung cancer patients were estimated using Cox, Weibull, exponential, and Gompertz regression models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3961/jpmph.17.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459760PMC
March 2019
1 Read

[Neuroendocrine neoplasms : Two families with distinct features unified in one classification (German version)].

Authors:
G Klöppel

Pathologe 2019 Apr 10. Epub 2019 Apr 10.

Institut für Pathologie, Konsultationszentrum für Pankreas und Endokrine Tumoren, Technische Universität München, Trogerstr 18, 81675, München, Deutschland.

All neuroendocrine neoplasms (NENs) are characterized by the expression of synaptophysin and chromogranin A (or B). Yet, they are not a homogeneous group of tumors. Paradigmatic for these tumors are the NENs of the gastroenteropancreatic (GEP) system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00292-019-0594-3DOI Listing
April 2019
1 Read

The Italian Rare Pancreatic Exocrine Cancer Initiative.

Tumori 2019 Apr 9:300891619839461. Epub 2019 Apr 9.

1 Medical Oncology Unit, IRCCS Cancer Institute "Giovanni Paolo II" of Bari, Bari, Italy.

Introduction: Exocrine pancreatic cancers include common type pancreatic ductal adenocarcinoma and cystic neoplasms, which account for 85% and 10% of cases, respectively. The remaining 5% are rare histotypes, comprising adenosquamous carcinoma, acinar cell carcinoma, signet ring cell carcinoma, medullary carcinoma, pancreatoblastoma, hepatoid carcinoma, undifferentiated carcinoma and its variant with osteoclast-like giant cells, solid pseudopapillary carcinoma, and carcinosarcoma. Due to their low incidence, little knowledge is available on their clinical and molecular features as well as on treatment choices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300891619839461DOI Listing
April 2019
1 Read
1.090 Impact Factor

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial.

JAMA 2019 04;321(14):1370-1379

Yale Cancer Center, New Haven, Connecticut.

Importance: In observational studies, higher plasma 25-hydroxyvitamin D (25[OH]D) levels have been associated with improved survival in metastatic colorectal cancer (CRC).

Objective: To determine if high-dose vitamin D3 added to standard chemotherapy improves outcomes in patients with metastatic CRC.

Design, Setting, And Participants: Double-blind phase 2 randomized clinical trial of 139 patients with advanced or metastatic CRC conducted at 11 US academic and community cancer centers from March 2012 through November 2016 (database lock: September 2018). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2019.2402DOI Listing
April 2019
2 Reads

Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers: The AMATERASU Randomized Clinical Trial.

JAMA 2019 04;321(14):1361-1369

Department of Surgery, International University of Health and Welfare Hospital, Tochigi, Japan.

Importance: Randomized clinical trials of vitamin D supplementation for secondary prevention in patients with cancer are needed, given positive results of observational studies.

Objective: To determine whether postoperative vitamin D3 supplementation can improve survival of patients with digestive tract cancers overall and in subgroups stratified by 25-hydroxyvitamin D (25[OH]D) levels.

Design, Setting, And Participants: The AMATERASU trial, a randomized, double-blind, placebo-controlled trial conducted at a single university hospital in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2019.2210DOI Listing
April 2019
2 Reads

Management of Complications of Colorectal Submucosal Dissection.

Clin Endosc 2019 Mar 29;52(2):114-119. Epub 2019 Mar 29.

Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Endoscopic submucosal dissection (ESD) is a useful procedure for the treatment of superficial gastrointestinal neoplasm. Compared with endoscopic mucosal resection (EMR), ESD has several benefits, which include resectability of various difficult lesion, accurate histologic assessment of specimen, and lower recurrence rate. However, the risk of procedure- related complications is higher with ESD than with EMR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5946/ce.2019.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453857PMC
March 2019
1 Read

Clinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours.

Tumour Biol 2019 Apr;42(4):1010428319835684

1 Unidad de Investigación, Hospital Costa del Sol, REDISSEC, Marbella, España.

We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p < 0.001). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1010428319835684DOI Listing

[Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):282-287

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinicopathological features, diagnosis and differential diagnosis of dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features. Five cases of DDLPS with IMT-like features were collected from the First Affiliated Hospital of Nanjing Medical University, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine and the First People's Hospital of Qinzhou between 2013 and 2018. EnVision method and fluorescence in situ hybridization (FISH) were used to detect the immunophenotype of the tumor cells and the profile of MDM2 gene amplification respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.004DOI Listing
April 2019
1 Read

[Clinicopathological significance of poorly differentiated clusters in colorectal adenocarcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):276-281

Department of Pathology, Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, Nanjing 210006, China.

To investigate the correlation between poorly differentiated clusters (PDCs) in colorectal adenocarcinomas with clinicopathological parameters and its clinicopathological significance. One hundred and eighty-three colorectal adenocarcinomas resected by radical proctocolecomy were collected at Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, from January to December 2017. There were 122 male and 61 female patients with age ranging from 42 to 89 years (mean of 68 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.003DOI Listing
April 2019
2 Reads

Five-year Recurrence-free Survival After Surgery Followed by Oral Chemotherapy for Gastric Cancer With Portal Vein Tumor Thrombosis.

Anticancer Res 2019 Apr;39(4):2233-2238

Department of Surgery, Kumamoto Chuo hospital, Kumamoto, Japan.

Gastric cancer with portal vein tumor thrombosis (GC-PVTT) is a rare condition with a very poor prognosis. A 64-year-old man with GC-PVTT was admitted to our hospital. His carcinoembryonic antigen level was slightly elevated (17. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13339DOI Listing
April 2019
3 Reads

Enteral Access Potentially Endangers Esophageal Carcinoma Patients Under Multi-modality Therapy: A Population-based Study.

Anticancer Res 2019 Apr;39(4):2227-2232

Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan, R.O.C.

Background/aim: This study aimed to evaluate the clinical outcome of esophageal cancer (EC) patients with enteral access (EA) undergoing multimodality therapy.

Patients And Methods: This retrospective study analyzed data between 1997 and 2012 in Taiwan using the National Health Insurance Research Database. Patients with newly-diagnosed EC undergoing multimodality therapy were identified and classified as either EA group or no-EA group. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13338DOI Listing
April 2019
8 Reads

Association of Statin Use and Oncological Outcomes After Neoadjuvant Radiotherapy in Patients With Rectal Cancer.

Anticancer Res 2019 Apr;39(4):2177-2182

Department of Surgery, Zealand University Hospital, Køge, Denmark.

Aim: The aim of the study was to examine if statin exposure during neoadjuvant chemoradiotherapy improves oncological outcomes in patients with rectal cancer.

Patients And Methods: The study cohort consisted of patients who were undergoing neoadjuvant chemoradiotherapy and resection for rectal cancer. The statin users were matched 1:1 with non-users using propensity score-based matching. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13332DOI Listing
April 2019
2 Reads

Exon 9 Mutation of Associated With Poor Survival in Patients With Epstein-Barr Virus-associated Gastric Cancer.

Anticancer Res 2019 Apr;39(4):2145-2154

Department of Hematology/Oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

Background: Epstein-Barr virus (EBV)-associated gastric cancer (GC) is known to harbor a significant enrichment of of phosphatidylinositol 4, 5-biphosphate 3- kinase catalytic subunit alpha isoform (PIK3CA). Therefore, this study investigated the clinical relevance and prognostic role of PIK3CA mutations in patients with EBV-GC.

Materials And Methods: After reviewing 1,318 consecutive cases of surgically resected GC, 120 patients were identified as EBV-positive using EBV-encoded RNA in situ hybridization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13328DOI Listing
April 2019
1 Read

Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer.

Anticancer Res 2019 Apr;39(4):2129-2138

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece

Background/aim: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) are considered one of the reasons for treatment failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13326DOI Listing

Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy.

Anticancer Res 2019 Apr;39(4):2113-2120

Unit of Digestive, Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France

Background/aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.

Patients And Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13324DOI Listing
April 2019
1 Read

Diagnosis of Lymph Node Metastasis in Colorectal Cancer by a Semi-dry Dot-blot Method.

Anticancer Res 2019 Apr;39(4):2069-2076

Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

Background/aim: This study aimed to examine whether the semi-dry dot-blot (SDB) method can correctly identify metastasis to lymph nodes in colorectal cancer.

Materials And Methods: A total of 200 dissected lymph nodes from 83 patients with colorectal cancer who underwent surgery between November 2013 and May 2016 were examined. Each lymph node was first examined by SDB using anti-pancytokeratin antibody (AE1/AE3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13318DOI Listing
April 2019
1 Read

Induction of CD3+ and FoxP3+ T Cells in Left-sided Colorectal Tumors After UFT/LV Chemotherapy.

Anticancer Res 2019 Apr;39(4):1997-2005

Pharmacology Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.

Background/aim: Immune checkpoint inhibitors are mainly used for right-sided, microsatellite instability-high colorectal tumors. In this study, the effects of oral uracil-tegafur plus leucovorin (UFT/LV) chemotherapy on the gene expressions of four immunotherapy targets and the amounts of tumor-infiltrating lymphocytes (TILs) were investigated.

Patients And Methods: Data of 260 patients with stage II or stage III colorectal cancer were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13310DOI Listing

Cytoplasmic E-Cadherin Expression Is Associated With Higher Tumour Level of VEGFA, Lower Response Rate to Irinotecan-based Treatment and Poorer Prognosis in Patients With Metastatic Colorectal Cancer.

Anticancer Res 2019 Apr;39(4):1953-1957

Department of Oncology and Radiotherapy, Turku University Hospital and University of Turku, Turku, Finland.

Background: The prognostic value of vascular endothelial growth factor-A (VEGFA) and epithelial cadherin (E-cadherin) expression in patients with metastatic colorectal cancer (mCRC) is controversial.

Materials And Methods: In this prospective study, patients diagnosed with mCRC between August 1, 1998, and August 30, 2003, at the Turku University Hospital, Finland were included. Expression of E-cadherin (membranous and cytoplasmic pattern) and VEGFA in tumour samples was assessed by immunohistochemistry. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13305DOI Listing
April 2019
4 Reads
1.872 Impact Factor

Frequent and Specific Involvement of Changes of the p16-RB Pathway in Esophageal Neuroendocrine Carcinoma.

Anticancer Res 2019 Apr;39(4):1927-1934

Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.

Aim: This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer.

Materials And Methods: Immunohistochemical staining was performed using the avidin-biotin complex detection method. The staining was evaluated as diffusely positive, heterogeneous (in 5-95% of tumor cells), or diffusely negative. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13302DOI Listing
April 2019
4 Reads

Synergistic Effects of Olaparib and DNA-damaging Agents in Oesophageal Squamous Cell Carcinoma Cell Lines.

Anticancer Res 2019 Apr;39(4):1813-1820

Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.

Background/aim: Chemotherapy is an important first-line treatment for oesophageal squamous cell carcinoma (ESCC). However, there are few secondary options. Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, enhances the cytotoxicity of various anticancer drugs and has been used to treat advanced ovarian and breast cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13288DOI Listing
April 2019
1 Read

Preliminary Observation on the Cytotoxic Activity of New Chlorophyllin Derivative RCD on Human Tumour Cell Lines .

Anticancer Res 2019 Apr;39(4):1807-1812

Iraklis Galatoulas Research Unit, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.

Background: Chlorophyllin is used in traditional Chinese medicine because of its anticancer properties. This article describes the preparation and cytotoxic activity of a reduced chlorophyllin derivative (RCD) on tumour cell lines.

Materials And Methods: RCD was prepared by reducing chlorophyllin with lithium aluminium hydride, and its solubility in the alkaline and organic phases are different from that of the parent compound chlorophyllin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13287DOI Listing
April 2019
1 Read

The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer.

Anticancer Res 2019 Apr;39(4):1719-1728

Cell and Experimental Pathology, Department of Translational Medicine, Clinical Research Centre, Lund University, Malmö, Sweden

Background: The wingless-type mammary tumour virus integration site 5A (WNT5A) agonist Foxy5 was shown in vitro to affect intracellular signalling implicated in the regulation of colonic cancer stem cells (CSCs).

Materials And Methods: In order to study whether Foxy5 can modulate CSCs, either HT-29 or Caco-2 human colonic cancer cells, both lacking endogenous WNT5A expression, were inoculated subcutaneously into nude mice.

Results: Foxy5 reduced the expression of the stem-cell marker aldehyde dehydrogenase and, interestingly, the specific colon CSC marker double cortin-like kinase 1. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13278DOI Listing
April 2019
1 Read

Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles.

Anticancer Res 2019 Apr;39(4):1705-1710

University College London Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, Royal Free Campus, London, U.K.

Background/aim: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them attractive agents for biomedical applications. Mechano-growth factor (MGF) is an isoform of IGF1 and its expression has been demonstrated in malignancies including prostate cancer.

Materials And Methods: Near-infrared-emitting gold nanoparticles (AuNPs) were synthesized and conjugated to MGF. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13276DOI Listing
April 2019
2 Reads
1.872 Impact Factor

Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus.

Anticancer Res 2019 Apr;39(4):1689-1698

Department of Integrated TCM & Western Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, P.R. China

Background/aim: This study aimed to identify biomarkers for predicting the prognosis of advanced gastric cancer patients who received docetaxel, cisplatin, and S-1 (DCS).

Materials And Methods: Gene expression profiles were obtained from the Gene Expression Omnibus database (GSE31811). Gene-Ontology-enrichment and KEGG-pathway analysis were used for evaluating the biological functions of differentially-expressed genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13274DOI Listing
April 2019
2 Reads

Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review.

Anticancer Res 2019 Apr;39(4):1651-1660

General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy.

Background: Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13270DOI Listing
April 2019
1.872 Impact Factor

Health Technology Assessment of Carbon-ion Beam Radiotherapy: A Systematic Review of Clinical Effectiveness and Safety for 54 Oncological Indications in 12 Tumour Regions.

Anticancer Res 2019 Apr;39(4):1635-1650

Ludwig Boltzmann Institute for Health Technology Assessment (LBI-HTA), Vienna, Austria.

Background/aim: Due to the unique physical dose distribution of carbon-ion radiotherapy (CIRT), CIRT can be regarded as a novel tumour irradiation technique - potentially advantageous for various tumour types. Yet it is unclear in how far, superiority or inferiority can be claimed when comparing CIRT to standard irradiation. This study aimed to assess the scientific evidence regarding the effectiveness and safety of CIRT. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13269DOI Listing
April 2019
5 Reads

Short-Term Outcomes of Robotic Laparoscopic Total Mesorectal Excision for Rectal Cancer: A Cohort Study.

Am Surg 2019 Mar;85(3):294-302

The aim of this study was to evaluate and compare the intestinal function recovery time and other short-term outcomes between robotic-assisted total mesorectal excision (R-TME) and laparoscopic total mesorectal excision (L-TME) for rectal cancer. This is a retrospective study using a prospectively collected database. Patients' records were obtained from Gansu Provincial Hospital between July 2015 and October 2017. Read More

View Article

Download full-text PDF

Source
March 2019
1 Read

Clinical significance of wound infiltration with ropivacaine for elderly patients in china underwent total laparoscopic radical gastrectomy: A retrospective cohort study.

Medicine (Baltimore) 2019 Apr;98(14):e15115

Department of Gastrointestinal Surgery, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen.

The study aimed to evaluate analgesic effects and postoperative recovery of ropivacaine wound infiltration for elderly patients in China after total laparoscopic radical gastrectomy.We retrospectively received clinical data of 132 elderly patients who received total laparoscopic gastrectomy and tracheal intubation general anesthesia from cancer center of First Affiliated Hospital of Xiamen University between September 2014 and September 2017, patients were divided into 2 groups according to local injection of drug: group I (ropivacaine group, 0.5% ropivacaine, 40 mL in total, n = 69), group II (control group, no analgesic, n = 63). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015115DOI Listing
April 2019
1 Read

Ulcerative colitis with mucosal lesions in duodenum: Two case reports.

Medicine (Baltimore) 2019 Apr;98(14):e15035

Department of General Surgery, Tianjin Union Medical Center, Tianjin, China.

Rationale: Ulcerative colitis (UC) is a chronic, nonspecific, inflammatory disease of the colon. Colorectal is the main target organ of UC, while other digestive tract involvement is rare. This report describes 2 rare cases of duodenal mucosa lesions in patients with UC after total colectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015035DOI Listing
April 2019
3 Reads

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Apr;98(14):e15029

Department of Thoracic Surgery.

Background: The prognostic significance of tumor length in esophageal cancer (EC) remains controversial. Hence, we conducted a meta-analysis to quantitatively assess the prognostic significance of tumor length in EC patients.

Method: A systematic literature search was conducted in the PubMed, EMBASE, and Web of Science. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015029DOI Listing
April 2019
3 Reads