403,382 results match your criteria Gastrointestinal Neoplasms


Metastases of soft tissue sarcoma to the liver: A Historical Cohort Study from a Hospital-based Cancer Registry.

Cancer Med 2020 Jul 10. Epub 2020 Jul 10.

Sarcoma Center, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan.

Background: Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type.

Methods: From a Hospital-based Cancer Registry, 658 patients registered between 2007 and 2017 with soft tissue sarcomas were evaluated. Read More

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http://dx.doi.org/10.1002/cam4.3304DOI Listing

Next-generation sequencing demonstrates the rarity of short kinase variants specific to quadruple wild-type gastrointestinal stromal tumours.

J Clin Pathol 2020 Jul 9. Epub 2020 Jul 9.

South West Genomic Laboratory Hub, Southmead Hospital, Bristol, UK.

Aim: There is no known specific biomarker or genetic signal for quadruple wild-type (qWT) gastrointestinal stromal tumours (GISTs). By next-generation sequencing (NGS) of different GIST subgroups, this study aimed to characterise such a biomarker especially as a potential therapeutic target.

Methods And Results: An NGS panel of 672 kinase genes was applied to DNA extracted from 11 wild-type GISTs (including three qWT GISTs) and 5 mutated GISTs. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206613DOI Listing

Service evaluation of faecal immunochemical testing introduced for use in North East London for patients at low risk of colorectal cancer.

J Clin Pathol 2020 Jul 9. Epub 2020 Jul 9.

Surgery, Barts Health NHS Trust, London, UK.

Aims: Colorectal cancer (CRC) is the fourth most common cancer in the UK. Following National Institute of Clinical Excellence (NICE) guidance for faecal immunochemical testing (FIT) (DG30), we introduced a service for the measurement of faecal haemoglobin (fHb) in symptomatic patients in line with the 2017 update of the NG12 guidance. The purpose of this study was to audit the use of FIT, focussing on the indication for request and referral for diagnostic tests as recommended in NICE guidance. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206632DOI Listing

Abdominal neoplastic manifestations of neurofibromatosis type 1.

Neurooncol Adv 2020 Jul 25;2(Suppl 1):i124-i133. Epub 2020 Jun 25.

Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary tumor syndrome, with a wide clinicopathologic spectrum. It is defined by characteristic central nervous system, cutaneous and osseous manifestations, and by mutations in the NF1 gene, which is involved in proliferation via p21, RAS, and MAP kinase pathways. Up to 25% of NF1 patients develop intra-abdominal neoplastic manifestations including neurogenic (commonly plexiform neurofibromas and malignant peripheral nerve sheath tumors), interstitial cells of Cajal (hyperplasia, gastrointestinal stromal tumors), neuroendocrine, and embryonal tumors (rhabdomyosarcoma). Read More

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http://dx.doi.org/10.1093/noajnl/vdaa032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317050PMC

Durable benefit from immunotherapy and accompanied lupus erythematosus in pancreatic adenocarcinoma with DNA repair deficiency.

J Immunother Cancer 2020 Jul;8(2)

Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

Background: Clinical trials showed limited benefit of anti-PD-1 (programmed cell death 1) monotherapy in pancreatic adenocarcinoma patients and immune-related adverse events caused by immune checkpoint inhibitors were rarely reported in pancreatic adenocarcinoma. Here, we report the first case of durable benefit along with systemic lupus erythematosus following immunotherapy in mismatch repair-proficient pancreatic cancer.

Case Presentation: We describe a 57-year-old woman with resected stage ⅢB pancreatic cancer who underwent several lines of conventional chemotherapy after multiple lymph node metastases. Read More

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http://dx.doi.org/10.1136/jitc-2019-000463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342819PMC

High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer.

Int J Urol 2020 Jul 7. Epub 2020 Jul 7.

Division of Molecular Oncology, Department of Urology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Objective: To estimate the outcomes of high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy in prostate cancer patients classified as very high risk by the National Comprehensive Cancer Network.

Methods: Between June 2009 and September 2015, 66 patients meeting the criteria for very high-risk disease received high-dose-rate brachytherapy (2 fractions of 9 Gy) as a boost of external beam radiotherapy (13 fractions of 3 Gy). Androgen deprivation therapy was administered for approximately 3 years. Read More

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http://dx.doi.org/10.1111/iju.14305DOI Listing

Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series.

J Clin Pathol 2020 Jul 6. Epub 2020 Jul 6.

Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Aim: Blue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206757DOI Listing

Spontaneous perforation of jejunal gastrointestinal stromal tumor: A case report.

Int J Surg Case Rep 2020 Jun 27;73:31-34. Epub 2020 Jun 27.

Department of Radiology, Jordanian Royal Medical Services (JRMS), Amman, Jordan. Electronic address:

Introduction: The incidence of small bowel tumors is comparatively rare when compared to colonic tumors. They comprise less than 10% of all gastrointestinal neoplasms. Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract; however it accounts for less than 1% of all gastrointestinal tumors. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.088DOI Listing

Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer.

Gastric Cancer 2020 Jul 4. Epub 2020 Jul 4.

Center for Gastric Cancer, National Cancer Center, Goyang, Korea.

Background: This study aimed to investigate risk factors for lymph node (LN) or distant metastasis after non-curative endoscopic resection (ER) of undifferentiated-type early gastric cancer (EGC).

Methods: Of 1124 patients who underwent ER for undifferentiated-type gastric cancer at 18 tertiary hospitals across six geographic areas in Korea between 2005 and 2014, 634 with non-curative ER beyond the expanded criteria were retrospectively enrolled. According to the treatment after ER, patients were divided into additional surgery (n = 270) and follow-up (n = 364) groups. Read More

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http://dx.doi.org/10.1007/s10120-020-01103-2DOI Listing

Mesenchymal neoplasms of the tubular gut and adjacent structures: experience with EUS-guided fine-needle aspiration cytopathology.

J Am Soc Cytopathol 2020 Jun 10. Epub 2020 Jun 10.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Introduction: Unlike epithelial malignancies, mesenchymal neoplasms arising within the tubular gut are less often encountered in endoscopic ultrasound-guided (EUS) fine-needle aspiration biopsies (FNABs). Nonetheless, preoperative diagnosis of such neoplasms has important therapeutic and prognostic value. We report our experience with this category of neoplasms from the past decade. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.05.009DOI Listing

[Emerging roles of Hippo signaling pathway in gastrointestinal cancers and its molecular mechanisms].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(1):35-43

Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Hippo signaling pathway is highly conservative in evolution. MST1/2, LATS1/2, and the effector protein YAP/TAZ are the core members of this signaling pathway in mammalian cells. There have been many studies on YAP/TAZ and its downstream, however, the upstream regulatory factors of the Hippo signaling pathway remain unclear, and become one of the hot research directions of this pathway at present. Read More

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[Radioactive Enteritis and Gut Microecology].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):405-409

Department of Gastrointestinal Surgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine, Tsinghua University,Beijing 102218,China.

Radioactive enteritis(RE)is one of the most serious and common complications of intestinal tract caused by radiotherapy for malignant tumors in abdominal cavity,pelvic cavity,or retroperitoneum.Involved intestinal diseases are widespread,complex,and persistent,which make treatment difficult and ineffective.Short bowel syndrome can develop in some serious cases. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11448DOI Listing

[Bioinformatics Analysis and Preliminary Functional Study of Abnormal Expression of Splicing Factors in Gastric Cancer].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):289-296

State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences, CAMS and PUCM,Beijing 100005,China.

To analyze the expression of splicing factors in gastric cancer using bioinformatics methods and investigate the effect of aberrantly expressed serine/arginine-rich splicing factor(SRSF10)on the phenotype of gastric cancer cells. The RNA-seq data of gastric cancer and paracancerous tissues were downloaded from The Cancer Genome Atlas(TCGA)cancer database,and bioinformatics analysis was performed to obtain the splicing factors differentially expressed in gastric cancer.The splicing factor SRSF10 was selected to investigate its effect on the development of gastric cancer. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11414DOI Listing

Impact of OCT4 and Its Related Signaling Pathways on Gastrointestinal Cancers: Focusing on Targeted Therapy.

Iran J Allergy Asthma Immunol 2020 Jun 23;19(3):229-242. Epub 2020 Jun 23.

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

There are many pieces of evidence support the effect of cancer stem cells on the initiation and progression of cancer. However, related mechanisms involved in these phenomena are far more complicated to understand. The function of different stemness factorsin cancer stem cells (CSCs) and their complex associations at different levels of cancer have been reported. Read More

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http://dx.doi.org/10.18502/ijaai.v19i3.3451DOI Listing

Models of gastroenteropancreatic neuroendocrine neoplasms - Current status and future directions.

Neuroendocrinology 2020 Jul 2. Epub 2020 Jul 2.

Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET) and poorly differentiated gastroenteropancreatic neuroendocrine carcinomas (NEC). Since GEP-NEN represent rare diseases only limited data from large prospective, randomized clinical trials are available, and recommendations for treatment of GEP-NEN are in part based on data from retrospective analyses or case series. Read More

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http://dx.doi.org/10.1159/000509864DOI Listing

Screening of gastrointestinal cancers during COVID-19: a new emergency.

Authors:
Maida Marcello

Lancet Oncol 2020 07;21(7):e338

Gastroenterology and Endoscopy Unit, S. Elia-M. Raimondi Hospital, 93100 Caltanissetta, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(20)30341-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324111PMC

Perforated Ileal GIST Associated with Meckel Diverticulum - A Rare Pathological Entity of Surgical Acute Abdomen.

Chirurgia (Bucur) 2020 May-Jun;115(3):404-409

The GIST tumors are very rare entities ( 1% of all tumors). They originate in the Cajal interstitial cells, which are part of the autonomic nervous system of the intestine. Their most common location is the stomach, followed by the small intestine. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.404DOI Listing

The Value of Endoscopy as a Predictive Factor when Evaluating the Clinical Response to Neoadjuvant Chemoradiotherapy for Patients with Rectal Cancer.

Chirurgia (Bucur) 2020 May-Jun;115(3):373-379

Standard treatment rectal cancer according to numerous international guidelines recommends neoadjuvant chemoradiotherapy (nCRT). Literature data suggests that a better response to nCRT (greater tumour regression) leads to improved overall survival rates (OS) and disease-free survival rates (DFS). Tumour response to nCRT can be assessed either through clinical or pathological examination. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.373DOI Listing

Parameters for Predicting Tumour Response Following Neoadjuvant Chemoradiotherapy for Patients with Rectal Cancer.

Chirurgia (Bucur) 2020 May-Jun;115(3):365-372

Pathologic response following neoadjuvant chemoradiotherapy (nCRT) can vary from pathologic complete response (pCR), to tumour downstaging or minimum to no response. Our goal was to evaluate the parameters that could predict response to neoadjuvant therapy for patients with rectal cancer. Method: We performed a retrospective study and reviewed the medical documentation for patients that received treatment for rectal cancer in our surgical department between 2014-2018 and received nCRT. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.365DOI Listing

Systematic review and meta-analysis of diet quality and colorectal cancer risk: is the evidence of sufficient quality to develop recommendations?

Crit Rev Food Sci Nutr 2020 Jul 2:1-10. Epub 2020 Jul 2.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

The quality of existing evidence about the impact of diet quality on colorectal cancer (CRC) risk has only rarely been assessed. In the current review, we searched PubMed, EMBASE, Web of Science, Cochrane, and the resulting references (up to January 2020) for studies that evaluated the role of high diet quality by extreme dietary index categorization and the risk of CRC. Two researchers independently performed the study selection, data extraction, and quality assessment. Read More

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http://dx.doi.org/10.1080/10408398.2020.1786353DOI Listing

Appendiceal diverticulosis in a patient with family history of Birt-Hogg-Dubé syndrome--a case report.

Radiol Case Rep 2020 Aug 24;15(8):1317-1322. Epub 2020 Jun 24.

Department of Radiology, Section of Vascular and Interventional Radiology, University of Missouri- Columbia, One Hospital Drive, Columbia, MO, 65212, USA.

Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disorder that predisposes patients to cutaneous tumors, pulmonary cysts with recurrent spontaneous pneumothoraces, and a variety of renal neoplasms including hybrid oncocytic and chromophobe renal cell carcinomas. There has been much debate regarding the genetic link with the occurrence of colorectal cancer and other colonic anomalies. Associations between BHD and intestinal adenomatous polyposis and sigmoid diverticulosis have been described in the literature, but there have been no prior reports of appendiceal diverticulosis in patients with BHD. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322125PMC

T-cell and NK-cell neoplasms of the gastrointestinal tract - recurrent themes, but clinical and biological distinctions exist.

Authors:
Elaine S Jaffe

Haematologica 2020 Jul;105(7):1760-1762

Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.3324/haematol.2020.252924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327655PMC

Patient-reported and doctor-reported symptoms when faecal immunochemical tests are requested in primary care in the diagnosis of colorectal cancer and inflammatory bowel disease: a prospective study.

BMC Fam Pract 2020 Jul 1;21(1):129. Epub 2020 Jul 1.

Department of Public Health and Clinical Medicine, Unit of Research, Education and Development - Östersund, Östersund Hospital, Umeå University, Umeå, Sweden.

Background: Rectal bleeding and a change in bowel habits are considered to be alarm symptoms for colorectal cancer and they are also common symptoms for inflammatory bowel disease. However, most patients with these symptoms do not have any of these diseases. Faecal immunochemical tests (FITs) for haemoglobin are used as triage tests in Sweden and other countries but little is known about the symptoms patients have when FITs are requested. Read More

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http://dx.doi.org/10.1186/s12875-020-01194-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331274PMC

[Establishment and clinical testing of pancreatic cancer Faster R-CNN AI system based on fast regional convolutional neural network].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):520-524

Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, China.

To investigate the effectiveness of an enhanced CT automatic recognition system based on Faster R-CNN for pancreatic cancer and its clinical value. In this study, 4 024 enhanced CT imaging sequences of 315 patients with pancreatic cancer from January 2013 to May 2016 at the Affiliated Hospital of Qingdao University were collected retrospectively, and 2 614 imaging sequences were input into the faster R-CNN system as training dataset to create an automatic image recognition model, which was then validated by reading 1 410 enhanced CT images of 135 cases of pancreatic cancer.In order to identify its effectiveness, 3 750 CT images of 150 patients with pancreatic lesions were read and a followed-up was carried out. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20191017-00515DOI Listing

[Early experience of minimal invasive surgery for adolescent with pancreatic head tumor: a report of 15 cases].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):512-515

Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital, Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, China.

To summarize the characteristics and difficulties of minimal invasive surgery for adolescent with pancreatic head tumor. The data of adolescent younger than 28 years old with pancreatic head tumor treated at Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital from January 2014 to December 2019 were analyzed retrospectively. Fifteen cases were enrolled, included 5 males and 10 females. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200211-00077DOI Listing

[Metastatic gastrointestinal hepatoid adenocarcinoma of the liver: a high-grade carcinoma that is easily confused with primary hepatocellular carcinoma].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):710-714

Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China; Department of Pathology, Drum Tower School of Clinical Medicine, Nanjing Medical University, Nanjing 210008, China.

To investigate the clinicopathologic and immunophenotypic features of metastatic gastrointestinal hepatoid adenocarcinomas in the liver. Eight cases of hepatic metastatic gastrointestinal hepatoid adenocarcinoma diagnosed at the Affiliated Drum Tower Hospital, Nanjing University Medical School from January 2009 to January 2019 were retrospectively analyzed. The clinical data, histopathologic features and immunohistochemical (IHC) characteristics performed by EnVision method were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191123-00753DOI Listing

[Esophageal and esophago-gastric junction cancer : management and multimodal treatment].

Rev Med Suisse 2020 Jul;16(699):1292-1299

Service de chirurgie viscérale, HUG, 1211 Genève 14.

Esophageal cancer remains an oncological burden with a low survival rate. Multidisciplinary management is essential to offer an adjusted treatment to the patient general condition and the tumor stage. New minimally invasive surgical treatments help to reduce the surgical trauma and improve post-operative patient recovery. Read More

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Transthoracic Versus Transhiatal Esophagectomy for Esophageal Cancer: A Nationwide Propensity Score-Matched Cohort Analysis.

Ann Surg Oncol 2020 Jun 30. Epub 2020 Jun 30.

Amsterdam UMC, Department of Surgery, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

Background: Chemoradiation followed by resection has been the standard therapy for resectable (cT1-4aN0-3M0) esophageal carcinoma in the Netherlands since 2010. The optimal surgical approach remains a matter of debate. Therefore, the purpose of this study was to compare the transhiatal and the transthoracic approach concerning morbidity, mortality and oncological quality. Read More

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http://dx.doi.org/10.1245/s10434-020-08760-8DOI Listing

Goblet Cell Adenocarcinoma With Heterotopic Ossification: A Rare Case Report and Review of Literature.

Cureus 2020 May 27;12(5):e8312. Epub 2020 May 27.

Pathology and Laboratory Medicine, University of Louisville, Louisville, USA.

Heterotopic bone formation is a rare phenomenon when associated with gastrointestinal neoplasms. Here we present a rare case of heterotopic ossification associated with goblet cell adenocarcinoma of the appendix, and a literature review of such cases associated with neoplasms within and out of the gastrointestinal tracts. We reviewed the clinical data and when available, immunohistochemical markers of osteoblastic differentiation. Read More

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http://dx.doi.org/10.7759/cureus.8312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320657PMC

Laparoscopic Open Surgery for Stage II/III Colon Cancer Patients With Body Mass Index >25 kg/m.

In Vivo 2020 Jul-Aug;34(4):2079-2085

Department of Surgery, Yokohama City University, Yokohama, Japan.

Aim: To compare long- and short-term outcomes of laparoscopic surgery with those of open surgery for patients with colorectal cancer and body mass index over 25 kg/m Patients and Methods: This multicentre, retrospective study analysed clinical records and identified 178 patients with body mass index over 25 kg/m who underwent surgery for colon and rectosigmoid cancer between 2000 and 2016. After applying propensity score matching, 96 patients were finally included. The primary outcome was the 3-year recurrence-free survival rate, and the secondary outcomes were short-term results during and after surgery. Read More

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http://dx.doi.org/10.21873/invivo.12011DOI Listing

Increased incidence of metachronous gastric neoplasm after endoscopic resection in patients with synchronous gastric neoplasm.

BMC Gastroenterol 2020 Jun 30;20(1):206. Epub 2020 Jun 30.

Division of Gastroenterology & Hepatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-GU, Seoul, 137-701, South Korea.

Background: Recurrence risk is a major concern after endoscopic resection (ER) of gastric neoplasms. This study was to compare metachronous risk in patients with and without synchronous neoplasms after complete ER.

Methods: After ER for gastric neoplasms, patients were divided into those with and without synchronous neoplasm. Read More

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http://dx.doi.org/10.1186/s12876-020-01358-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325240PMC

Patient-Reported Quality of Life and Convalescence after Minimally Invasive Kidney Cancer Surgery.

Urology 2020 Jun 27. Epub 2020 Jun 27.

Beth Israel Deaconess Medical Center, Division of Urology; Boston, MA. Electronic address:

Objective: To better characterize recovery after minimally invasive kidney surgery, we present a study describing patient-reported health-related quality of life (HRQOL) following minimally invasive radical nephrectomy (RN) and partial nephrectomy (PN).

Methods: Patients who underwent minimally invasive PN or RN for renal cancer were invited to enroll in a prospective, patient-reported HRQOL study using the Convalescence and Recovery Evaluation (CARE) instrument and Short Form-12 (SF-12). Patients completed questionnaires at baseline, 2, 4, 8 and 12 weeks after surgery. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.020DOI Listing

FGFR4 Gly388Arg Polymorphism Affects the Progression of Gastric Cancer by Activating STAT3 Pathway to Induce Epithelial to Mesenchymal Transition.

Cancer Res Treat 2020 May 25. Epub 2020 May 25.

Department of Gastrointestinal Surgery and Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Purpose: Fibroblast growth factor receptor 4 (FGFR4) plays a critical role in cancer progression involving in tumor proliferation, invasion, and metastasis. This study clarified the role of FGFR4-Arg388 variant in gastric cancer (GC), and more importantly highlighted the possibility of this single nucleotide polymorphism (SNP) as potential therapeutic targets.

Materials And Methods: FGFR4 polymorphism was characterized in advanced GC patients to perform statistical analysis. Read More

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http://dx.doi.org/10.4143/crt.2020.138DOI Listing

[Diseases of biliary tract in the context of association with oncological diseases of the digestive system].

Ter Arkh 2019 Dec 15;91(12):98-104. Epub 2019 Dec 15.

Sechenov First Moscow State Medical University (Sechenov University).

Cancers of the gastrointestinal tract are widespread among the population and cause significant damage to the health care system. In order to improve the strategy of preventive measures and the detection of oncological diseases at the early stages, it is necessary to provide timely impact on possible risk factors contributing to the onset and progression of malignant neoplasms. This review demonstrates the association between the pathology of the biliary tract and oncological diseases of the digestive system, discusses the possible mechanisms of the influence of cholelithiasis and cholecystectomy on the development of malignant neoplasms of various parts of the gastrointestinal tract. Read More

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http://dx.doi.org/10.26442/00403660.2019.12.000455DOI Listing
December 2019

Sister Mary Joseph Nodule in a Patient With Advanced Prostate Cancer.

J Am Osteopath Assoc 2020 Jul;120(7):476-478

Prostate cancer is the second most common cause of cancer death among US men. Metastasis typically occurs in the bone, lymph nodes, liver, and thorax. This case highlights a patient who was suspected of having prostate cancer several years before presenting to the emergency department with back pain and an umbilical hernia of increasing size. Read More

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http://dx.doi.org/10.7556/jaoa.2020.075DOI Listing

Advantages of Restoring miR-205-3p Expression for Better Prognosis of Gastric Cancer via Prevention of Epithelial-mesenchymal Transition.

J Gastric Cancer 2020 Jun 18;20(2):212-224. Epub 2020 May 18.

Department of General Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.

Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Read More

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http://dx.doi.org/10.5230/jgc.2020.20.e19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311212PMC

Primary signet ring cell carcinoma with tubular adenoma of the rectum: A case report and a review of the literature.

Medicine (Baltimore) 2020 Jun;99(26):e20985

Department of General Surgery, The Second Hospital of Jilin University.

Rationale: Among the various forms of colorectal carcinomas, primary signet ring cell carcinoma (SRCC) of rectum is infrequent. Primary SRCC with adenoma is even rarer. Due to its low morbidity and lack of obvious manifestations at early stages, it is difficult to make an early diagnosis and perform surgical intervention in time. Read More

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http://dx.doi.org/10.1097/MD.0000000000020985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328922PMC

Xiaoaiping injection as adjunct therapy for patients with advanced esophageal carcinoma: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20984

Department of General Surgery, People's Hospital of Weifang Binhai Economic and Technological Development Zone, Weifang, Shandong Province, China.

Background: Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chinese herbal medicine, has been widely applied as a promising adjunctive drug for EC. Read More

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http://dx.doi.org/10.1097/MD.0000000000020984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328972PMC

The diagnostic accuracy of digital PCR, ARMS and NGS for detecting KRAS mutation in cell-free DNA of patients with colorectal cancer: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20708

Department of Physiology, College of Medicine, Chengdu University, Chengdu, China.

Introduction: Cetuximab and panitumumab have been used clinically to treat metastatic colorectal cancer for more than 15 years. Before the treatment is given, it is required to determine the KRAS mutation status since it would lead to drug resistance. Tumor tissue sample is traditionally used for cancer genotyping. Read More

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http://dx.doi.org/10.1097/MD.0000000000020708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328928PMC
June 2020
5.723 Impact Factor

Clinical efficacy of adjuvant chemotherapy in the treatment of pT4 stage II colorectal cancer with defective mismatch repair status: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20693

Department of Gastrointestinal Surgery, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.

Background: The aim of this systematic review and meta-analysis is to assess the efficacy of adjuvant chemotherapy in patients with stage IIB/C CRC and defective mismatch repair (dMMr) status, and to evaluate what is the determinant risk factor for adjuvant chemotherapy in those patients.

Method: A systematic search of PubMed, EMBASE, Web of science, Cochrane Library databases will be performed. All RCTs published in electronic databases from inception to March 19, 2020, with language restricted in English will be included in this review study. Read More

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http://dx.doi.org/10.1097/MD.0000000000020693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328979PMC

High expression of ghrelin and obestatin prepropeptide in tumor tissues predicted adverse overall survival in gastric carcinoma patients.

Medicine (Baltimore) 2020 Jun;99(26):e20635

Department of Surgical Oncology, Taizhou Cancer Hospital, Wenling, PR China.

Background: Gastric cancer (GC) is the most prevailing digestive tract malignant tumor worldwide with high mortality and recurrence rates. However, its potential molecular mechanism and prognostic biomarkers are still not fully understood. We aim to screen novel prognostic biomarkers related to GC prognosis using comprehensive bioinformatic tools. Read More

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http://dx.doi.org/10.1097/MD.0000000000020635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328939PMC

Stellate Cells in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1263:67-84

Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

As tumor microenvironments share many of the same qualities as chronic wounds, attention is turning to the wound-repair cells that support the growth of cancerous cells. Stellate cells are star-shaped cells that were first discovered in the perisinusoidal spaces in the liver and have been found to support wound healing by the secretion of growth factors and extracellular matrix. They have since been also found to serve a similar function in the pancreas. Read More

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http://dx.doi.org/10.1007/978-3-030-44518-8_6DOI Listing

Diet Quality and Upper Gastrointestinal Cancers Risk: A Meta-Analysis and Critical Assessment of Evidence Quality.

Nutrients 2020 Jun 23;12(6). Epub 2020 Jun 23.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands.

We aimed to assess the effect of a high-quality diet on the risk of upper gastrointestinal cancer and to evaluate the overall quality of our findings by searching PubMed, EMBASE, Web of Science, Cochrane, and the references of related articles to February 2020. Two reviewers independently retrieved the data and performed the quality assessments. We defined the highest-quality diet as that with the lowest Diet Inflammatory Index category and the highest Mediterranean Diet Score category. Read More

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http://dx.doi.org/10.3390/nu12061863DOI Listing

Activities of matrix metalloproteinase-2, matrix metalloproteinase-9, and serine proteases in samples of the colorectal mucosa of Miniature Dachshunds with inflammatory colorectal polyps.

Am J Vet Res 2020 Jul;81(7):572-580

Objective: To investigate the activities of gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9) and serine proteases in the colorectal mucosa of Miniature Dachshunds (MDs) with inflammatory colorectal polyps (ICRPs).

Animals: 15 MDs with ICRPs and 5 dogs with non-ICRP-related large bowel diarrhea (controls).

Procedures: Zymographic methods were used to evaluate the activities of MMP-2, MMP-9, latent forms of MMP-2 and MMP-9 (pro-MMP-2 and pro-MMP-9), and serine proteases in inflamed and noninflamed tissue samples from MDs with ICRPs and in noninflamed tissue samples from control dogs. Read More

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http://dx.doi.org/10.2460/ajvr.81.7.572DOI Listing

-Negative MALT Lymphoma Presenting as a Massive Recurrent Gastrointestinal Hemorrhage.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620937166

SUNY Upstate Medical University, Syracuse, NY, USA.

Primary gastric lymphoma is rare, representing 5% of all primary gastric neoplasms. The presenting complaints of gastric mucosa-associated lymphoid tissue (MALT) lymphoma are usually nonspecific. However, life-threatening gastrointestinal bleeding from the stomach is unusual and sparsely reported. Read More

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http://dx.doi.org/10.1177/2324709620937166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318806PMC

Endoscopic Submucosal Dissection of Gastrointestinal Stromal Tumours: A Retrospective Cohort Study.

Cancer Manag Res 2020 29;12:4055-4061. Epub 2020 May 29.

Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Background: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms. Endoscopic submucosal dissection (ESD) has been used to remove submucosal tumours for many years. However, whether ESD can be recommended for the treatment of GISTs is still controversial. Read More

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http://dx.doi.org/10.2147/CMAR.S252459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269634PMC

Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract.

Nagoya J Med Sci 2020 May;82(2):175-182

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Nonexposed wall-inversion surgery was invented for the treatment of node-negative gastrointestinal tumors that are difficult to be resected using the endoluminal approach alone. The advantages of this surgery include 1. full-thickness resection procedure of gastrointestinal wall with minimum necessary tumor-negative margins and 2. Read More

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http://dx.doi.org/10.18999/nagjms.82.2.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276399PMC

The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms.

J Gastrointest Surg 2020 Jun 23. Epub 2020 Jun 23.

Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, China.

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http://dx.doi.org/10.1007/s11605-020-04651-1DOI Listing

[Short-term efficacy of totally laparoscopic left colon cancer radical resection with overlapped delta-shaped anastomosis technique].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):507-512

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To evaluate the safety, feasibility and short-term efficacy of totally laparoscopic left colectomy for left colon cancer by using overlapped delta-shaped anastomosis technique for digestive tract reconstruction. A retrospective cohort study was conducted to collect the clinical data of 86 patients with left colon cancer who underwent laparoscopic surgery in Cancer Hospital of Chinese Academy of Medical Sciences from October, 2017 to February, 2019. The patients were divided into totally laparoscopic left-sided colectomy (TLLC) (treatment group, =25 cases) and laparoscopic-assisted left-sided colectomy (LALC) (control group, =61 cases). Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190707-00415DOI Listing