361,816 results match your criteria Gastrointestinal Endoscopy[Journal]


Up-Regulation of MiR-1915 Inhibits Proliferation, Invasion, and Migration of -Infected Gastric Cancer Cells via Targeting RAGE.

Yonsei Med J 2019 Jan;60(1):38-47

Department of Gastrointestinal Tumor, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Purpose: -infected gastric cancer (GC) is known to be a fatal malignant tumor, but the molecular mechanisms underlying its proliferation, invasion, and migration remain far from being completely understood. Our aim in this study was to explore miR-1915 expression and its molecular mechanisms in regulating proliferation, invasion, and migration of -infected GC cells.

Materials And Methods: Quantitative real-time PCR and western blot analysis were performed to determine miR-1915 and receptor for advanced glycation end product (RAGE) expression in -infected GC tissues and gastritis tissues, as well as human gastric mucosal cell line GES-1 and human GC cell lines SGC-7901 and MKN45. Read More

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January 2019
2 Reads

Deficiencies in postoperative surveillance for veterans with gastrointestinal cancer.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Department of Surgery, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.

Background And Objectives: National guidelines for gastrointestinal (GI) cancers offer surveillance algorithms to facilitate detection of recurrent disease, yet adherence rates are unknown. We sought to characterize postoperative surveillance patterns for veterans with GI cancer at a tertiary care Veterans Affairs Hospital.

Methods: A single-center retrospective cohort study identified patients who underwent surgical resection for colorectal, gastroesophageal or hepatopancreaticobiliary malignancy from 2010-2016. Read More

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December 2018

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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December 2018

Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury.

Digestion 2018 Dec 14;99(1):66-71. Epub 2018 Dec 14.

Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury. Read More

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December 2018

Chronic GI bleeding in a middle-aged woman.

Gut 2018 Dec 15. Epub 2018 Dec 15.

Department of Gastroenterology and Hepatology, Kobe City Medical Center General Hospital, Kobe, Japan.

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December 2018

DNA variants in Helicobacter pylori infected patients with chronic gastritis, dysplasia and gastric cancer.

Adv Med Sci 2018 Dec 13;64(1):79-84. Epub 2018 Dec 13.

Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland. Electronic address:

Purpose: The main scope of this study was to evaluate the importance of selected DNA variants for developing inflammation of gastric mucosa and carcinogenesis in gastrointestinal diseases in patients infected with Helicobacter pylori.

Patients And Methods: Patients subjected to analysis constituted a group of 131 consecutive cases, with control groups consisting of 100 healthy volunteers and 13 dyspeptic patients. Molecular analysis included the following genes: TP53 (c. Read More

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December 2018

Use of probiotics in aquaculture of China-a review of the past decade.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Sino-Norway Fish Gastrointestinal Microbiota Joint Lab, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

China is the largest aquaculture producer in the world. Antibiotics were extensively used to ensure the development of the intensive aquaculture; however, the use of antibiotics causes safety- and environment-associated problems. As an alternative strategy to antibiotics, aquatic probiotics have attracted attention. Read More

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December 2018

Constipation in a cohort prospective in adult critically ill patients: How much occurs and why?

Enferm Intensiva 2018 Dec 12. Epub 2018 Dec 12.

Postgraduate Program in Nursing, Nursing School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

Objective: To assess the incidence and factors associated with constipation in adult critical care patients.

Design: Prospective cohort study.

Setting: Intensive care unit (ICU) of a high-complexity hospital from November 2015 to October 2016. Read More

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December 2018

An unusual case of gastrointestinal basidiobolomycosis mimicking colon cancer; literature and review.

J Mycol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Mycology/Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Gastrointestinal basidiobolomycosis (GIB), a rare fungal infection associated with high mortality, has been reported worldwide mainly from tropical and subtropical regions of Asia, USA, and Latin America. The clinical manifestations are highly diverse and non-specific depending on the underlying disease, but fever, abdominal pain, weight loss, diarrhea, constipation and chills have been observed. There are no prominent risk factors for GIB but climatic conditions and life style are related to this infection in arid and semi-arid regions. Read More

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December 2018

Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice.

Vaccine 2018 Dec 13. Epub 2018 Dec 13.

Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan. Electronic address:

We reported previously that a synthetic mucosal adjuvant SF-10, which mimics human pulmonary surfactant, delivers antigen to mucosal dendritic cells in the nasal cavity and promotes induction of humoral and cellular immunity. The aim of the present study was to determine the effects of oral administration of antigen combined with SF-10 (antigen-SF-10) on systemic and local immunity. Oral administration of ovalbumin, a model antigen, combined with SF-10 enhanced ovalbumin uptake into intestinal antigen presenting MHC IICD11c cells and their CD11bCD103 and CD11bCD103 subtype dendritic cells, which are the major antigen presenting subsets of the intestinal tract, more efficiently compared to without SF-10. Read More

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December 2018

Primary extranodal diffuse large B-cell lymphomas: Many sites, many entities? Clinico-pathological, immunohistochemical and cytogenetic study of 106 cases.

Cancer Genet 2018 Dec 28;228-229:28-40. Epub 2018 Aug 28.

Department Of Medicine and Surgery, Unit of Pathology, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy. Electronic address:

We analyzed the clinicopathological, immunohistochemical and cytogenetic features of 106 extranodal (EN) diffuse large B-cell lymphomas (DLBCLs) from stomach (34 cases), intestine (10), cervico-cephalic region (11), central nervous system (13), testes (21), skin (8), and miscellaneous sites (9). Hans' algorithm and the immunohistochemical double expressor score (DES) for MYC and BCL2 were applied to all cases. A subset of fifty-eight cases were analyzed with fluorescent in situ hybridization (FISH) with specific break apart probes for BCL6, MYC, BCL2, CCND1, BCL10 and MALT1 genes. Read More

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December 2018
1 Read

In vitro permeability enhancement of curcumin across Caco-2 cells monolayers using electrospun xanthan-chitosan nanofibers.

Carbohydr Polym 2019 Feb 29;206:38-47. Epub 2018 Oct 29.

Nano-BioScience Research Group, DTU-Food, Technical University of Denmark, Kemitorvet, B202, 2800 Kgs. Lyngby, Denmark. Electronic address:

Xanthan-Chitosan (X-Ch) polysaccharides nanofibers were prepared using electrospinning processing as an encapsulation and delivery system of curcumin (Cu). The X-Ch-Cu nanofibers remained stable in aqueous HBSS medium at pH 6.5 and pH 7. Read More

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February 2019

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report.

J Med Case Rep 2018 Dec 16;12(1):370. Epub 2018 Dec 16.

Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan.

Background: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Read More

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December 2018

The therapeutic potential of curcumin: A review of clinical trials.

Eur J Med Chem 2018 Dec 7;163:527-545. Epub 2018 Dec 7.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 11369, Iran; Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, R3B 2G3, Canada. Electronic address:

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Read More

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December 2018
5 Reads
3.447 Impact Factor

Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism.

J Nutr Biochem 2018 Nov 10;64:206-217. Epub 2018 Nov 10.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Normally, the gut microbiota has a mutually beneficial association with host health and maintains its commensal status in mammals. Conversely, it can also negatively influence host physiology under some certain circumstances, including obesity and other disease states. Although numerous gut microbial functions directly affect the gastrointestinal tract, in this paper, we focus on the influences of the gut microbiota on host adipose tissue and energy metabolism, particularly lipometabolism. Read More

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November 2018
1 Read

A case of completely isolated advanced enteric duplication cyst cancer performed partial pancreatectomy.

Int J Surg Case Rep 2018 Nov 27;54:83-86. Epub 2018 Nov 27.

Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Nishiiwata 3-4-5, Higashiosaka, Osaka, 567-8588, Japan.

Introduction: Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Read More

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November 2018

Epidemiology and etiology of diarrhea in UK military personnel serving on the United Nations Mission in South Sudan in 2017: A prospective cohort study.

Travel Med Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Academic Department of Military Medicine, Medical Directorate, Defence Medical Services, Birmingham, UK.

Background: . Diarrhea is a well-established problem in travellers, with military personnel at especially high risk. This study aimed to characterise the spectrum of pathogens causing diarrhea in UK military personnel in South Sudan, and assess the utility of culture-independent testing for etiology and antimicrobial resistance in a logistically challenging and austere environment. Read More

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December 2018
1.538 Impact Factor

Prepared for the Unexpected: Accessory Ovaries with Abernethy Malformation.

J Minim Invasive Gynecol 2018 Dec 12. Epub 2018 Dec 12.

Oregon Health & Science University, Department of Surgery.

Supernumerary and accessory ovaries are collectively coined ectopic ovaries. These are rarely encountered by the benign gynecologist, and are often discovered incidentally during evaluation for other gynecologic, gastrointestinal or urologic pathologies. We report the presentation of a patient with multiple accessory ovaries in addition to a rare congenital anomaly of the splanchnic vasculature called an Abernethy malformation. Read More

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December 2018
1 Read

Clinical relevance of enteropathogen co-infections in preschool children - a population-based repeated cross-sectional study.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Objectives: This study aimed to (i) determine risk factors for enteropathogen co-infections, (ii) determine whether enteropathogen co-infections influence gastroenteritis risk, and (iii) determine whether enteropathogen co-infection occurred randomly in preschool children.

Methods: A monthly-repeated cross-sectional survey in Dutch children aged 0-48 months was conducted during October 2012-October 2014. 981 stool samples were collected along with questionnaires collecting data on gastrointestinal symptoms and potential risk factors. Read More

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December 2018

Automated small-scale in vitro transfer model as screening tool for the prediction of in vivo-dissolution and precipitation of poorly solubles.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Institute of Pharmacy, Department of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Strasse 3, 17489 Greifswald, Germany. Electronic address:

Precipitation testing, especially for weakly basic APIs, represents a key parameter in drug substance characterization during early development stages, where the amount of API available is limited. Therefore, it was the aim of this study to develop an automated small-scale in vitro transfer model to characterize the supersaturation and precipitation behavior of two poorly water-soluble drugs. Following automation and scale-down of the standard transfer model, the developed small-scale model was used to assess the impact of gastrointestinal variability, i. Read More

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December 2018

Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Oncological Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China. Electronic address:

Ethnopharmacological Relevance: The development of a multidrug-resistant (MDR) phenotype is a main obstacle to the successful treatment of breast cancer. Saponins of several herbs are considered as promising candidates for drug resistance treatment. We extracted Paris saponin VII (PS VII) from Trillium tschonoskii Maxim. Read More

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December 2018
1 Read

Intestinal parasites and lungworms in stray, shelter and privately owned cats of Switzerland.

Parasitol Int 2018 Dec 12. Epub 2018 Dec 12.

University of Zurich, Vetsuisse Faculty, Institute of Parasitology, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

Endoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples additionally by the Baermann technique. Read More

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December 2018

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

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December 2018

Transitional care for patients with surgical pediatric hepatobiliary disease: choledochal cysts and biliary atresia.

J Gastroenterol Hepatol 2018 Dec 15. Epub 2018 Dec 15.

University of Rochester School of Medicine, Rochester, NY, USA.

Choledochal cysts (CDCs) and biliary atresia (BA) are rare pediatric hepatobiliary anomalies that require surgical intervention due to increased risk of malignancy and liver failure, respectively. The underlying disease and operative procedures place patients at risk for long-term complications, which may continue to affect them into adulthood. Lack of a transitional care model in the health care system potentiates the challenges they will face following aging out of their pediatric providers' care. Read More

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December 2018

Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: A large-scale prospective study.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.

Background: To develop and validate practical prognostic indexes (PIs) for predicting the prognosis and response to postoperative adjuvant therapy in patients with oral squamous cell carcinoma (OSCC).

Methods: A large cohort of 1071 OSCC patients were randomized to either training set (N = 708) or validation set (N = 363). Three types of PIs were developed according to the nomogram scores, β coefficients and excess hazard ratios, respectively. Read More

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December 2018
1 Read

Dynamic changes of fatty acids and minerals in sow milk during lactation.

J Anim Physiol Anim Nutr (Berl) 2018 Dec 14. Epub 2018 Dec 14.

National Center for International Research on Animal Gut Nutrition, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu Province, China.

The objective of the present study was to explore the changes in fatty acids (FAs) and minerals composition in sow milk in order to improve the knowledge about FAs and mineral requirements for piglets. The FAs and minerals composition in the sow milk samples which were collected from ten sows during a period of 16 days of lactation was analysed. The proportion of FAs in sow milk has a significant increase in C8:0, C10:0, C12:0, C14:0, C16:0, C14:1 and C16:1 FAs and the sum of saturated fatty acids (SFAs) according to the lactation period (p < 0. Read More

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December 2018
1 Read

EFFECT OF TIME OF THE DAY AND SPECIALITY ON POLYP DETECTION RATES IN AUSTRALIA.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, the University of Adelaide, Adelaide, South Australia, Australia.

Background And Aim: Adenoma detection rate (ADR) is an important quality metric in colonoscopy. However, there is conflicting evidence around factors that influence ADR. This study aims to investigate the effect of time of day and endoscopist background on ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) for screening colonoscopies. Read More

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December 2018
1 Read

Exopolymeric substances (EPS) from Salmonella enterica: polymers, proteins and their interactions with plants and abiotic surfaces.

J Microbiol 2018 Sep 6. Epub 2018 Sep 6.

Department of Natural Sciences, Faculty of Science and Technology, Middlesex University, London, NW4 4BT, UK.

When Salmonella enterica is not in a planktonic state, it persists in organised communities encased in extracellular polymeric substances (EPS), defined as biofilms. Environmental conditions ultimately dictate the key properties of the biofilms such as porosity, density, water content, charge, sorption and ion exchange properties, hydrophobicity and mechanical stability. S. Read More

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September 2018
1 Read

[The rich diversity of Whipple's disease].

Z Rheumatol 2018 Dec 14. Epub 2018 Dec 14.

Klinik für Rheumatologie, Immunologie und Osteologie, Krankenhaus St. Josef Wuppertal, Bergstr. 6-12, 42105, Wuppertal, Deutschland.

Whipple's disease (WD) is a rare, chronic multiorgan disease which can caused by Tropheryma whipplei, a ubiquitous gram positive bacterium. Detection of T. whipplei is mostly performed histologically using periodic acid-Schiff (PAS) staining in affected tissues to visualize characteristic PAS-positive macrophages and by the polymerase chain reaction (PCR). Read More

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December 2018

Direct electrochemical biosensing in gastrointestinal fluids.

Anal Bioanal Chem 2018 Dec 14. Epub 2018 Dec 14.

Department of Nanoengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.

Edible electrochemical biosensors with remarkable prolonged resistance to extreme acidic conditions are described for direct glucose sensing in gastrointestinal (GI) fluids of different pH ranges and compositions. Such direct and stable glucose monitoring is realized using carbon-paste biosensors prepared from edible materials, such as olive oil and activated charcoal, shown to protect the activity of the embedded glucose oxidase (GOx) enzyme from strongly acidic conditions. The enzymatic resistance to low-pH deactivation allowed performing direct glucose monitoring in strong acidic environments (pH 1. Read More

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December 2018
1 Read

Acute Pancreatitis Caused by Ampullary Duodenum Adenoma in a Patient with Adenomatous Polyposis Coli with Billroth II Reconstruction After Distal Gastrectomy.

Am J Case Rep 2018 Dec 15;19:1495-1498. Epub 2018 Dec 15.

Department of Gastroenterology, Kita-Harima Medical Center, Ichiba, Ono, Hyogo, Japan.

BACKGROUND Adenomatous polyposis coli is an autosomal dominant hereditary disorder. Duodenal adenocarcinoma and adenoma, which are extracolonic lesions, not only affect the prognosis of patients but also cause acute pancreatitis. CASE REPORT We present the case of a 73-year-old male. Read More

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December 2018

Cost of oropharyngeal dysphagia after stroke: protocol for a systematic review.

BMJ Open 2018 Dec 14;8(12):e022775. Epub 2018 Dec 14.

Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain.

Introduction: Oropharyngeal dysphagia (OD) is a major disorder following stroke. OD can produce alterations in both the efficacy and safety of deglutition and may result in malnutrition, dehydration, frailty, respiratory infections and pneumonia. These complications can be avoided by early detection and treatment of OD in poststroke patients, and hospital stays, medication and mortality rates can be reduced. Read More

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December 2018

The management of mid & proximal oesophageal squamous cell carcinoma.

Authors:
Ian Wong Simon Law

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:85-90. Epub 2018 Nov 30.

Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong. Electronic address:

Despite the rise in incidence of adenocarcinoma, squamous cell cancer of the oesophagus remains the commonest cell type worldwide and is predominant in the East. Except for very early tumours where endoscopic therapy can be performed with curative intent, in more advanced but potentially curative cancers, treatment for mid and upper third tumours is primarily surgery with extended lymphadenectomy, together with multimodal therapies such as preoperative chemotherapy or chemoradiotherapy. Definitive chemoradiotherapy is utilized in those who decline surgery or in those who are unfit for major procedures. Read More

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November 2018
3.478 Impact Factor

Peri-operative patient optimization for oesophageal cancer surgery - From prehabilitation to enhanced recovery.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:61-73. Epub 2018 Nov 30.

Department of Gastrointestinal Medicine and Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK; Division of Cancer Studies, King's College London, UK. Electronic address:

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November 2018

Risk factors for oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:3-8. Epub 2018 Nov 22.

Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; School of Cancer and Pharmaceutical Sciences, King's College London, United Kingdom.

The two main histological subtypes of oesophageal cancer, squamous cell carcinoma and adenocarcinoma, have distinct risk factor profiles. For oesophageal squamous cell carcinoma, tobacco smoking and excess alcohol use are the main risk factors. For adenocarcinoma, gastro-oesophageal reflux disease and obesity are main risk factors, whereas tobacco smoking is a moderately strong risk factor and infection with Helicobacter pylori decreases the risk. Read More

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November 2018

[Constitutional MMR deficiency: Genetic bases and clinical implications].

Bull Cancer 2018 Dec 11. Epub 2018 Dec 11.

Paris Sciences Lettres Research University, institut Curie, département de génétique, 75005 Paris, France; Sorbonne Universités, UPMC université Paris 06, Centre de recherche Saint-Antoine, Inserm, CNRS, 75012 Paris, France. Electronic address:

Inherited mono-allelic mutation in one of the 4 major MMR genes results in Lynch syndrome which predisposes, in adulthood, mainly to colorectal and endometrial tumors characterized by microsatellite instability (MSI phenotype). Individuals with bi-allelic mutations of one of these genes developed early and multiple malignancies, most often in childhood. This recessively inherited condition is named CMMRD for Constitutional Mismatch Repair Deficiency. Read More

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December 2018
1 Read

Pediatric Fatty Liver and Obesity: Not Always Justa Matter of Non-Alcoholic Fatty Liver Disease.

Children (Basel) 2018 Dec 13;5(12). Epub 2018 Dec 13.

Pediatrics Residency Joint Programs, University of Naples Federico II, 80131 Naples, Italy.

Obesity-related non-alcoholic fatty liver disease (NAFLD) represents the most common cause of pediatric liver disease due to overweight/obesity large-scale epidemics. In clinical practice, diagnosis is usually based on clinical features, blood tests, and liver imaging. Here, we underline the need to make a correct differential diagnosis for a number of genetic, metabolic, gastrointestinal, nutritional, endocrine, muscular, and systemic disorders, and for iatrogenic/viral/autoimmune hepatitis as well. Read More

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December 2018

DA-9701 (Motilitone): A Multi-Targeting Botanical Drug for the Treatment of Functional Dyspepsia.

Authors:
Mirim Jin Miwon Son

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Research Center & Phytotherapeutics Group, Viromed, Co. Ltd., Seoul 08826, Korea.

Functional dyspepsia (FD) is the most common functional gastrointestinal disorder (FGID). FD is characterized by bothersome symptoms such as postprandial fullness, early satiety, and epigastric pain or burning sensations in the upper abdomen. The complexity and heterogeneity of FD pathophysiology, which involves multiple mechanisms, make both treatment and new drug development for FD difficult. Read More

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December 2018

A Mini Review on Antidiabetic Properties of Fermented Foods.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

In general, fermented foods (FFs) are considered as functional foods. Since the awareness about the health benefits of FFs has increased, the consumption of FF also improved significantly in recent decades. Diabetes is one of the leading threats of the health span of an individual. Read More

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December 2018

Relationships between Microbial Indicators and Pathogens in Recreational Water Settings.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Department of Integrative Biology, University of South Florida, 4202 East Fowler Ave, SCA 110, Tampa, FL 33620, USA.

Fecal pollution of recreational waters can cause scenic blight and pose a threat to public health, resulting in beach advisories and closures. Fecal indicator bacteria (total and fecal coliforms, , and enterococci), and alternative indicators of fecal pollution ( and bacteriophages) are routinely used in the assessment of sanitary quality of recreational waters. However, fecal indicator bacteria (FIB), and alternative indicators are found in the gastrointestinal tract of humans, and many other animals and therefore are considered general indicators of fecal pollution. Read More

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December 2018

Piceatannol pretreatment alleviates acute cardiac injury via regulating PI3K-Akt-eNOS signaling in H9c2 cells.

Biomed Pharmacother 2019 Jan 5;109:886-891. Epub 2018 Nov 5.

VIP Department, Qingdao Municipal Hospital, Shandong, 266071, China. Electronic address:

Piceatannol (3,3',4,5'-trans-trihydroxystilbene) is a natural polyphenols compound that occurs hydroxylated analogue of resveratrol showing widely biological activities. Previous studies have demonstrated its functions on anti-cancer, neuroprotection and cardioprotection. However, few studies have clarified the benefits of piceatannol on cardiomyocytes except its anti-oxidative effect based on the original property of polyphenols. Read More

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January 2019
2 Reads

Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice.

Biomed Pharmacother 2019 Jan 28;109:2252-2261. Epub 2018 Nov 28.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Background: Gegen Qinlian decoction (GQT), is a classic traditional Chinese medicine formula chronicled in Shang Han Lun, and is widely used to treat diarrhea and inflammation symptoms in various gastrointestinal disorders. Although it has been found to inhibit delayed-onset mice diarrhea resulted from irinotecan (CPT-11) administration in preliminary experiments, the underlying mechanisms and chemical components remain elusive.

Methods: The effective fraction of GQT by macroporous resin elution was obtained and screened using a diarrhea mouse model induced by CPT-11 and quantified by UPLC analysis. Read More

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January 2019
1 Read

Long non-coding RNA XIST promotes the development of esophageal cancer by sponging miR-494 to regulate CDK6 expression.

Biomed Pharmacother 2019 Jan 28;109:2228-2236. Epub 2018 Nov 28.

Department of Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China. Electronic address:

Objective: Esophageal cancer is one of the deadliest cancers worldwide occurring at upper gastrointestinal tract. This study aimed to explore the possible role of long non-coding RNA X Inactive Specific Transcript (XIST) in the development of esophageal cancer.

Material And Methods: The lncRNA XIST expressions both in esophageal cancer tissues and in cells were investigated. Read More

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January 2019

Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1 by up-regulation of miR-449a.

Biomed Pharmacother 2019 Jan 26;109:1951-1959. Epub 2018 Nov 26.

Department of Gastroenterology, Linyi Central Hospital, Linyi, 276400, China. Electronic address:

Background: Gastrointestinal stromal tumor (GIST) threatens the health of middle-aged and older people with high recurrence rate and low survival rate. In this study, Neferin (Nef) was hoped to control growth and migration of GIST cell line GIST-T1.

Methods: Cell viability, proliferation, apoptosis, and migration were determined by cell counting kit-8 (CCK-8) assay, bromodeoxyuridine (BrdU) assay, Annexin V-FITC/PI double staining method, and Transwell assay, respectively. Read More

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January 2019

Protection afforded by methanol extract of Calotropis procera latex in experimental model of colitis is mediated through inhibition of oxidative stress and pro-inflammatory signaling.

Biomed Pharmacother 2019 Jan 15;109:1602-1609. Epub 2018 Nov 15.

Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India.

Calotropis procera, a latex producing plant is known to possess medicinal properties including its beneficial effect in gastrointestinal disorders. The anti-inflammatory effect of its latex in various experimental models is noteworthy and in light of this the present study was carried out with an objective to evaluate its efficacy in ulcerative colitis, an inflammatory condition of the colon. Colitis was induced in rats by acetic acid and the rats were divided into four groups where one group served as experimental control and the other groups were treated with two doses of methanol extract of dried latex of C. Read More

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January 2019

Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease.

J Crohns Colitis 2018 Dec 14. Epub 2018 Dec 14.

The Children's Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA.

Background And Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize the diagnostic histological findings in patients with VEO-IBD as compared to older onset pediatric IBD and determine if there are unique pathological changes that can shed light on the driving forces of the disease, particularly immunodeficiencies. Read More

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December 2018

Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study.

Nutrition 2018 Oct 12;60:106-111. Epub 2018 Oct 12.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: In this study we sought to investigate the effect of early enteral bovine colostrum supplementation on intestinal permeability in intensive care unit (ICU)-hospitalized patients.

Methods: A total of 70 ICU-hospitalized adult patients were randomly assigned to receive a bovine colostrum supplement or placebo according to the stratified blocked randomization by age and admission category. Plasma endotoxin and zonulin concentrations were measured on days 5 and 10 of intervention. Read More

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October 2018

Ventilator-associated pneumonia: The central role of transcolonization.

J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

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December 2018
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