Search Our Scientific Publications & Authors

Biomed J 2019 02 2;42(1):27-35. Epub 2019 Mar 2.

Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA. Electronic address:

A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. Read More

Rev Inst Med Trop Sao Paulo 2019 4;61:e19. Epub 2019 Apr 4.

Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil.

Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Read More

Taiwan J Obstet Gynecol 2019 Mar;58(2):177-182

R.G.Kar Medical College and Hospital, India.

Pregnancy can be complicated with different surgical emergencies which may potentially endanger the mother as well as foetus. In the modern era of advanced diagnostics and treatments, neither of them in response to a surgical emergency in a pregnant woman should be delayed. Appropriate early intervention is essential to decrease the morbidity and mortality. Read More

Int Braz J Urol 2019 Mar 20;45. Epub 2019 Mar 20.

Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: No comprehensive information is available about uterus fatty acid (FA) change during implantation period and possible effects of the seminal vesicle secretion on it.

Materials And Methods: In this study, we evaluated FA composition of uterus phospholipids during the implantation period in intact and seminal vesicle-excised (SVX) mated female mice. Forty NMRI female mice were divided into control (mated with intact male) and seminal vesicle excised (SVX)-mated (mated with SVX-male) groups. Read More

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Department of Obstetrics and Gynecology, OLVG, Amsterdam, The Netherlands.

We present a 22-year-old pregnant woman at 15 weeks of gestation, with abdominal pain and vomiting. We demonstrate that diagnosis and treatment of vomiting and abdominal pain in pregnancy can be difficult. Therefore, involvement of other medical specialists is important when common treatments fail. Read More

Cochrane Database Syst Rev 2019 03 14;3:CD007411. Epub 2019 Mar 14.

Department of Gynaecology and Obstetrics, Radboud University Medical Center, Nijmegen, Netherlands.

Background: The inability to have children affects 10% to 15% of couples worldwide. A male factor is estimated to account for up to half of the infertility cases with between 25% to 87% of male subfertility considered to be due to the effect of oxidative stress. Oral supplementation with antioxidants is thought to improve sperm quality by reducing oxidative damage. Read More

Cochrane Database Syst Rev 2019 03 13;3:CD012473. Epub 2019 Mar 13.

Child Health Department, Blackpool Victoria Hospital, Whinney Heys Road, Blackpool, Lancashire, UK, FY3 8NR.

Background: Infantile colic is typically defined as full-force crying for at least three hours per day, on at least three days per week, for at least three weeks. Infantile colic affects a large number of infants and their families worldwide. Its symptoms are broad and general, and while not indicative of disease, may represent a serious underlying condition in a small percentage of infants who may need a medical assessment. Read More

Ginekol Pol 2019 ;90(2):93-99

Division of Reproduction, Department of Gynecology and Obstetrics, Poznan University of Medical Sciences, Poland.

Objectives: The aim of our work was to assess the development of children with antenatally diagnosed idiopathic poly- hydramnios, over 12 months from the end of pregnancy.

Material And Methods: The study included 91 healthy pregnant patients with idiopathic polyhydramnios. Diagnostic tests results and perinatal medical history were obtained retrospectively. Read More

Ann R Coll Surg Engl 2019 Apr 11;101(4):235-248. Epub 2019 Mar 11.

Laboratory of Experimental Surgery and Surgical Research, National and Kapodistrian University of Athens , Greece.

Introduction: Acute appendicitis is a common and serious situation during pregnancy, because of the increased risk of fetal loss and perforation in the third trimester, as well as a diagnostic difficulty. During recent years laparoscopic approach has been introduced to clinical practice with encouraging results. The purpose of this meta-analysis is to compare the surgical and obstetrical outcomes between laparoscopic and open appendectomy during pregnancy. Read More

Kidney Blood Press Res 2019 22;44(1):133-148. Epub 2019 Feb 22.

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany,

Background/aims: Paternal exposure to adverse environmental conditions can act on offspring's phenotype and influence offspring's later life disease risk. Our study was designed to examine the effect of feeding male rats before mating a high-fat, high-sucrose and high-salt diet (HFSSD) over two generations (F0 and F1) on their offspring's (F2) liver function and gut microbiome composition.

Methods: Male F0 rats and male F1 rats were fed either control diet or HFSSD before mating. Read More

Lancet 2019 03 21;393(10177):1183-1184. Epub 2019 Feb 21.

Department of Women's Health, Dell Medical School, University of Texas, Austin, TX 78705, USA. Electronic address:

Am J Obstet Gynecol 2019 Feb 18. Epub 2019 Feb 18.

Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:

Background: Smoking is one of the most important modifiable risk factors for adverse maternal and neonatal outcomes. Smoking during pregnancy has been associated with fetal growth restriction, adverse pregnancy outcomes, and chronic adult diseases. Existing research has evaluated the risk of smoking on congenital defects. Read More

Rozhl Chir Winter 2019;98(1):31-34

Introduction: Crohns disease (CD) as a chronic inflammatory disease can affect the entire digestive tract and therefore involves a wide range of symptoms and health problems. It often mimics other diseases of the digestive tract. In the case of acute abdomen in a patient with CD, it is necessary to approach it individually in cooperation with a gastroenterologist in order to reduce the extent of resection and to ensure fewer resections. Read More

Lancet 2019 03 14;393(10174):899-909. Epub 2019 Feb 14.

Department of Women and Children's Health, King's College London, London, UK. Electronic address:

Background: Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth.

Methods: We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Read More

Addiction 2019 Feb 6. Epub 2019 Feb 6.

Department of Addictology, First Faculty of Medicine, Charles University, Czech Republic.

Background And Aims: Our understanding of the long-term safety of prenatal exposure to opioid maintenance treatment (OMT) is insufficient. We compared childhood morbidity (0-3 years) between OMT-exposed and relevant comparison groups.

Design: Nation-wide, registry-based cohort study. Read More

J Mol Biol 2019 Jan 31. Epub 2019 Jan 31.

Department of Global Health, University of Washington, Seattle 98195, WA, USA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle 98101, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle 98195, WA, USA. Electronic address:

Group B streptococcus (GBS) is a β-hemolytic gram-positive bacterium that colonizes the lower genital tract of approximately 18% of women globally as an asymptomatic member of the gastrointestinal and/or vaginal flora. If established in other host niches, however, GBS is highly pathogenic. During pregnancy, ascending GBS infection from the vagina to the intrauterine space is associated with preterm birth, stillbirth, and fetal injury. Read More

Wiad Lek 2018;71(8):1541-1549

Kharkov National Medical University, Kharkiv, Ukraine.

Objective: Introduction: In children population of Ukraine the diseases of the gastrointestinal tract are quite common, among which a significant number of cases occur in liver diseases. The complexity of the liver functions formation in antenatal and intranatal periods, its morphofunctional immaturity lead to the high sensitivity of this organ to the influence of various factors from the mother organism. Actual issues are the detection of the mother's pathology influence on the formation of diseases «cargo» in children remote stages of ontogenesis. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14119

Department of Hematology, First Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, China.

Rationale: Acquired hemophilia A is a rare hemorrhagic disease in which the body produces specific antibodies that attack factor VIII, resulting in bleeding that is mainly mucocutaneous and associated with soft tissue and the gastrointestinal system. Approximately 50% of this disease derives from basic diseases, such as autoimmune diseases, cancer, and pregnancy.

Patient Concerns: We report a 35-year-old postpartum female with acquired hemophilia A who initially presented with pleural hemorrhage. Read More

JAMA 2019 Jan;321(2):188-199

Harvard Medical School, Boston, Massachusetts.

Importance: β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that increase the risk for antimicrobial resistance and adverse events.

Observations: Approximately 10% of the US population has reported allergies to the β-lactam agent penicillin, with higher rates reported by older and hospitalized patients. Read More

Inflamm Bowel Dis 2019 Jan 8. Epub 2019 Jan 8.

Northwestern University, Feinberg School of Medicine, Chicago Illinois.

Background: Human alpha-fetoprotein (hAFP) is a glycoprotein derived from the gut entoderm and expressed sequentially by cells of the yolk sac, fetal liver, and gastrointestinal tract. By adulthood, serum levels of alpha-fetoprotein (AFP) are undetectable in healthy, nonpregnant adults. Despite the clinical utilities of AFP monitoring in pregnancy and malignancy, much remains to be determined regarding its potential physiological functions. Read More

Environ Pollut 2019 Mar 24;246:630-638. Epub 2018 Dec 24.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, PR China. Electronic address:

Previous in vitro studies have implied that triphenyl phosphate (TPHP) may act as an obesogen. However, its specific contributions to the progression of obesity and related metabolic diseases are still unclear in vivo in mice. In this study, we evaluated the effects of in utero and lactational exposure to three doses of TPHP (10, 100, and 1000 μg/kg BW) on obesity and metabolic dysfunctions in adult male mice fed a low-fat diet (LFD) or high-fat diet (HFD), by examining body weight, liver weight, histopathology, blood biochemistry, gene expression, and gut microbiota compositions and metabolic functions. Read More

Afr Health Sci 2018 Sep;18(3):542-551

Ladoke Akintola University of Technology, PMB 4400, Osogbo, Nigeria.

Background: and soil transmitted helminth (STHs) infection are widespread in sub-Sahara Africa, where co-infection is also common. This study assessed the prevalence of these infections and their risk factors among pregnant women in Osogbo, Nigeria.

Methods: A total of 200 pregnant women attending the antenatal clinic were recruited. Read More

Pediatr Int 2018 Dec;60(12):1092-1093

Department of Pediatrics, Akita University Graduate School of Medicine, Akita, Japan.

J Neonatal Perinatal Med 2018 ;11(4):417-422

Faculty of Medicine, University of Ottawa, Canada.

Intrauterine intestinal obstruction complicated by midgut volvulus is a serious life-threatening diagnosis. Immediate surgical intervention is generally the course of action upon diagnosis to prevent morbidity and mortality. We report a case of intrauterine intestinal obstruction where the neonate then presented with an unusual onset of volvulus within the first 12 hours of life. Read More

BMC Womens Health 2018 12 22;18(1):205. Epub 2018 Dec 22.

Department of Gynecology and Obstetrics II and Reproductive Medicine, Centre Hospitalier Universitaire Cochin, Baˆtiment Port Royal, 53 avenue de l'Observatoire, Paris, 75014, France.

Background: To compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China.

Methods: A subgroup analysis of factors associated with DIE versus OMA was performed in Chinese women from the FEELING study. This study included 156 OMA patients and 78 DIE patients. Read More

Pan Afr Med J 2018 19;30:219. Epub 2018 Jul 19.

Service de Radiologie, Hôpital d'Enfants-Maternité Avicenne, Rabat, Maroc.

Caudal regression syndrome is a rare malformative syndrome associated, to varying degrees, with agenesis of sacral and coccygeal vertebrae, lower limb shortening and gastrointestinal, genitourinary and cardiovascular abnormalities. Its relationship with gestational diabetes is well established, but its exact cause is poorly established. We here report a rare case of caudal regression syndrome in a 8-month old infant of diabetic mother with polymalformative syndrome and chronic constipation. Read More

Pan Afr Med J 2018 16;30:212. Epub 2018 Jul 16.

Department of General and Digestive Surgery Farhat Hached Universitary Hospital, Sousse, Tunisia.

The occurrence of acute appendicitis during pregnancy may pose diagnostic and therapeutic difficulties. In fact pregnancy can make the clinical diagnosis delicate and the use of morphological examinations is still subject to controversy. The debates concerning the ideal surgical approach during pregnancy continue. Read More

Obstet Med 2018 Dec 5;11(4):178-181. Epub 2018 Jun 5.

Faculty of Medicine, University of Queensland, Brisbane, Australia.

Acute fatty liver of pregnancy is a rare complication of pregnancy that may result in fulminant hepatic failure. We present a review of all patients presenting to a quaternary obstetric hospital over a 15-year period, with particular regard to biochemical changes, results of gene testing, and pre-existing conditions. Seventeen patients with acute fatty liver of pregnancy were identified. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13707

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Eastern District, Beijing.

Rationale: Colorectal cancer (CRC) is the 2nd most common type of cancer in females and the 3rd in males, worldwide. It occurs rarely during pregnancy and is often associated with poor prognosis, due to the unspecific manifestations until advanced stage. Majority of CRC are localized in the rectum (63%) and the sigmoid colon (20%) during pregnancy. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Internal Medicine, St. Vincent Charity Medical Center, Cleveland, Ohio, USA.

The increasing demand and popularity of bariatric surgery are not only due to the ever-increasing obesity epidemic but to tackle obesity-related comorbidities like diabetes and hypertension. However, bariatric surgery is not free of complications. One rare complication is intussusception, jejuno-jejunal intussusception being the most common. Read More

Am J Hum Biol 2018 Dec 19:e23200. Epub 2018 Dec 19.

Department of Anthropology, Yale University, New Haven, Connecticut.

Objectives: Cesarean delivery may increase childhood infectious morbidity risks via altered birth exposures and subsequent immune, microbial, and epigenetic development. Many Latin American indigenous populations experience dual burdens of infectious and chronic diseases, and are particularly vulnerable to rising rates of cesarean delivery and associated adverse outcomes. The Qom/Toba are an indigenous population in Argentina experiencing rapid lifestyle transitions. Read More

JAMA 2018 12;320(23):2438-2447

Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.

Importance: Pelvic floor disorders (eg, urinary incontinence), which affect approximately 25% of women in the United States, are associated with childbirth. However, little is known about the course and progression of pelvic floor disorders over time.

Objective: To describe the incidence of pelvic floor disorders after childbirth and identify maternal and obstetrical characteristics associated with patterns of incidence 1 to 2 decades after delivery. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13352

First Affiliated Hospital of Guangzhou University of Chinese Medicine.

Rationale: Postoperative ileus with flatulence is a common symptom in patients who have undergone cesarean section, and it can lead to peritonitis and intestinal perforation. However, few previous reports described therapeutic effects of acupuncture in women with flatulence after cesarean delivery. We reported a case of 29-year-old woman with abdominal flatulence after cesarean section. Read More

Ann Pharmacother 2019 Jun 17;53(6):639-651. Epub 2018 Dec 17.

1 University of South Carolina College of Pharmacy, Columbia, SC, USA.

Objective: To review the treatment of common bacterial and viral infections occurring in the pregnant patient.

Data Sources: A literature search of MEDLINE was performed (inception to October 2018). The Centers for Disease Control and Prevention website was utilized for additional information. Read More

Mol Autism 2018 10;9:61. Epub 2018 Dec 10.

2Institute for Pediatric Regenerative Medicine and Shriners Hospitals for Children Northern California, 2504 Stockton Blvd, Sacramento, CA 95817 USA.

Background: Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota. Autism spectrum disorder (ASD) patients suffer from gastrointestinal problems and experience changes in gut microbiota; however, it is not yet clear whether the change in the microbiota associated with ASD is a cause or a consequence of the disease.

Methods: We have investigated the species richness and microbial composition in a valproic acid (VPA)-induced rat model autism. Read More

Cochrane Database Syst Rev 2018 12 12;12:CD012519. Epub 2018 Dec 12.

University of Vermont Medical Center, Burlington VT, USA.

Background: Inflammation may contribute to preterm birth and to morbidity of preterm infants. Preterm infants are at risk for alterations in the normal protective microbiome. Oral probiotics administered directly to preterm infants have been shown to decrease the risk for severe necrotizing enterocolitis (NEC) as well as the risk of death, but there are safety concerns about administration of probiotics directly to preterm infants. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):901-902

Department of Gastroenterology, Shaare Zedek Medical Center, Hebrew University Medical School of Jerusalem, Jerusalem, Israel.

Taiwan J Obstet Gynecol 2018 Dec;57(6):871-877

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Objective: The coexistence of maternal malignancy and pregnancy has received increasing attention in Noninvasive prenatal testing (NIPT) studies. Malignancy in pregnant women potentially affects the copy number variation (CNV) profile in NIPT results. Only one case of hematologic cancer has been reported in a Hong-Kong pregnant women, and solid tumors have never been reported in pregnant Chinese women. Read More

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

J Infect 2019 Mar 5;78(3):208-214. Epub 2018 Dec 5.

Reference Microbiology Services, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom; Gastrointestinal Infections Department, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom. Electronic address:

LISTERIOSIS: is a foodborne illness that can result in septicaemia, Central Nervous System (CNS) disease, foetal loss and death in high risk patients.

Objectives: To analyse the demographic trends, clinical features and treatment of non-perinatal listeriosis cases over a ten year period and identify mortality-associated risk factors.

Methods: Reported laboratory-confirmed non-pregnancy associated cases of listeriosis between 2006 and 2015 in England were included and retrospectively analysed. Read More

Radiologe 2019 Feb;59(2):126-132

Universitätsinstitut für Radiologie, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.

Background: Acute pelvic pain in women may be due to gynecological, gastrointestinal, and urinary tract disorders. Ectopic pregnancy (EP), pelvic inflammatory disease (PID), and ruptured ovarian cysts are the most common gynecological causes for acute pelvic pain and their diagnosis can be challenging.

Methods: Patient history, clinical examination, and blood tests as well as patient age and potential pregnancy status help to establish the correct diagnosis. Read More

Nat Commun 2018 11 30;9(1):5091. Epub 2018 Nov 30.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, avenue des Hauts-Fourneaux 7, 4362, Esch-sur-Alzette, Luxembourg.

The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. Read More

Vet Parasitol 2018 Dec 8;264:52-57. Epub 2018 Nov 8.

UNESP - Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, Botucatu, SP, CEP 18.618-689, Brazil.

Haemonchus contortus is an economic problem in sheep farms worldwide, mainly in the tropics and subtropics. A vaccine against haemonchosis, called Barbervax, was evaluated in ewes under two nutritional status, naturally infected with gastrointestinal nematodes. Ewes were divided into four groups: Supplemented Diet - Vaccine; Supplemented Diet - No vaccine; Basal Diet - Vaccine and Basal Diet - No vaccine. Read More

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):552-556

Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.

Background: The aim of this study was to compare the obstetric and surgical outcomes of laparoscopic appendectomy (LA) and open appendectomy (OA) performed for pregnant women at a single center. It was the hypothesis of this study that there would be no significant difference in the results.

Methods: The medical records of 57 consecutive pregnant women who underwent an appendectomy between January 2009 and September 2018 were reviewed retrospectively. Read More

World J Surg Oncol 2018 Nov 29;16(1):229. Epub 2018 Nov 29.

Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: The reports of pregnancy after total gastrectomy for gastric cancer are rare.

Case Presentation: We report a case of a 35-year-old woman, gravida 0, para 0, who became pregnant and delivered a baby 2 years and 6 months after laparoscopic-assisted total gastrectomy for early gastric cancer. Postoperatively, she showed a good progress during the follow-up and was continuously taking oral iron supplement and administered with methylcobalamin intramuscular injection. Read More

World J Gastroenterol 2018 Nov;24(42):4787-4797

Department of Dentistry and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton T6G2E1, Alberta, Canada.

Aim: To understand the effects of delivery mode on the immune cells frequency and function in cord blood and placenta.

Methods: We evaluated immunological differences in cord blood and placental tissues for a case of twins one of which delivered vaginally while the other delivered by caesarian section (C-section). Cord blood mononuclear cells were isolated and placenta tissues were processed for cell isolation. Read More

Eur J Pediatr 2019 Mar 23;178(3):301-314. Epub 2018 Nov 23.

Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Macrolides are bacteriostatic antibiotics with a broad spectrum of activity against Gram-positive bacteria. The aim of this study was to systematically review and meta-analyze the association between infantile hypertrophic pyloric stenosis (IHPS) and macrolides. Nine databases were searched systematically for studies with information on the association between macrolides and IHPS. Read More

Dis Colon Rectum 2019 01;62(1):63-70

Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: Many patients with fecal incontinence report coexisting constipation. This subset of patients has not been well characterized or understood.

Objective: The purpose of this study was to report the frequency of fecal incontinence with concurrent constipation and to compare quality-of-life outcomes of patients with fecal incontinence with and without constipation. Read More

Crit Care Nurs Clin North Am 2018 Dec 16;30(4):457-466. Epub 2018 Oct 16.

Cognitive Medical Systems, 9444 Waples Street, Suite 300, San Diego, CA 92121, USA.

Although a unit-adopted standardized feeding protocol (SFP) for neonates is standard of care, implementation strategies for SFPs vary across neonatal and pediatric intensive care. Besides improving growth and reducing feeding interruptions, SFPs reduce risk for necrotizing enterocolitis in infants with heart disease or born premature. The purpose of this article is to bridge the gap between recommended and actual care using SFPs. Read More

Anasthesiol Intensivmed Notfallmed Schmerzther 2018 Oct 13;53(10):696-702. Epub 2018 Nov 13.

The known guidelines before a planned operation on aspiration, fasting and preoperative risk evaluation also apply in obstetrics. Extended measures are only justified under concrete anamnestic or specific symptoms. Neuraxial anesthesia techniques should be offered to the mother as early as possible, as waiting for a certain opening of the cervix is not justified. Read More