Search Our Scientific Publications & Authors

J Crohns Colitis 2018 Dec 14. Epub 2018 Dec 14.

The Children's Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA.

Background And Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize the diagnostic histological findings in patients with VEO-IBD as compared to older onset pediatric IBD and determine if there are unique pathological changes that can shed light on the driving forces of the disease, particularly immunodeficiencies. Read More

Nutrition 2018 Oct 12;60:106-111. Epub 2018 Oct 12.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: In this study we sought to investigate the effect of early enteral bovine colostrum supplementation on intestinal permeability in intensive care unit (ICU)-hospitalized patients.

Methods: A total of 70 ICU-hospitalized adult patients were randomly assigned to receive a bovine colostrum supplement or placebo according to the stratified blocked randomization by age and admission category. Plasma endotoxin and zonulin concentrations were measured on days 5 and 10 of intervention. Read More

J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

Pharmacol Rep 2018 Oct 11;71(1):149-155. Epub 2018 Oct 11.

School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, Australia; Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD, Australia. Electronic address:

Background: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans.

Methods: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0. Read More

PLoS One 2018 14;13(12):e0209038. Epub 2018 Dec 14.

Department of Clinical Microbiology, Virology, and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden.

Human adenoviruses (HAdVs) are common pathogens that can cause respiratory, gastrointestinal, urogenital, and ocular infections. They are divided into seven species containing 85 genotypes. Straightforward typing systems might help epidemiological investigations. Read More

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1432-1433

Ingestion of magnetic foreign bodies is an increasing problem in the pediatric emergency in recent years.The majority of these injuries are ingestions involving the gastrointestinal tract, stomach, esophagus etc.Ingestion of multiple magnets has a high risk of bowel injury such as perforation or fistula. Read More

Nurs Stand 2018 Dec 10. Epub 2018 Dec 10.

The Royal London Hospital, London, England.

Inflammatory bowel disease (IBD) is a term that refers to two main conditions: Crohn's disease and ulcerative colitis. It is a lifelong inflammatory disorder that affects the gastrointestinal tract. Managing IBD requires a multidisciplinary team approach, and specialist IBD nurses have an important role in this, providing education, support and advocacy to patients with IBD. Read More

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 210000.

The reflux of gastric contents into the esophagus is a common complication post-esophagectomy. Endoscopic suturing technique is becoming a useful treatment in gastrointestinal tract. This system takes advantage of robust tissue approximation by use of a suturing needle, equal to that of surgery. Read More

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Graduate School of Informatics, Nagoya University, Nagoya, Japan.

With recent breakthroughs in artificial intelligence, computer-aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Read More

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastrointestinal Surgery, St. Luke's International Hospital, Tokyo, Japan.

We performed laparoscopic surgery for three cases of colorectal cancer using an 8K ultra-high-definition endoscopic system, which offers 16-fold higher resolution than the current 2K high-definition endoscope. The weight of the camera has been successfully reduced to 370 g. To maximize the advantages of the 8K ultra-high-definition endoscope, surgery was performed by darkening the room and placing a large 85-in. Read More

Asia Pac J Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine II, Osaka Medical College, Takatsuki, Osaka, Japan.

Aim: Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX-6 for gastric cancer patients with a gastrointestinal obstruction. Read More

Basic Clin Pharmacol Toxicol 2018 Oct 29. Epub 2018 Oct 29.

Neuropharmacology on Pain (NED), Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.

The threats involved in the long-term opioid treatment of chronic non-cancer pain (CNCP) have increased notably. Strategies to identify at-risk patients are important because there is no clear evidence showing which screening or deprescription programmes are appropriate. Our aim was to evaluate the evidence provided by pharmacogenetics applied to predict an analgesic toxicity profile in prescription opioid use disorder (POUD) patients participating in an opioid deprescription programme. Read More

Neurogastroenterol Motil 2018 Dec 14:e13526. Epub 2018 Dec 14.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.

The endogenous opioid system (EOS) is considered being a crucial element involved in the pathophysiology of irritable bowel syndrome (IBS) as it regulates gastrointestinal (GI) homeostasis through modulation of motility and water and ion secretion/absorption. Along with opioid receptors (ORs), the following components of EOS can be distinguished: 1. endogenous opioid peptides (EOPs), namely enkephalins, endorphins, endomorphins and dynorphins, and 2. Read More

Cancer Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.

Recently, there has been an increased attention to circulating tumor cells (CTCs) analysis, also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. CTCs are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Read More

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Microsatellite instability (MSI) is a prognostic marker in colorectal cancer (CRC). The biological significance of MSI-low (MSI-L) phenotype and its differences with microsatellite stable (MSS) phenotype remains unclear. The aim of this study is indicating the role of mononucleotide repeat in identifying MSI-L and revealing the association of MSI-L with elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and oncologic outcome in CRC patients. Read More

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The human epidermal growth factor 2 (HER2) gene undergoes various mutations that could alter its activity or respond to the antibody therapies. Cetuximab, a known anti-EGFR monoclonal antibody (mAB), is widely administered in metastatic colorectal cancer (mCRC) cases. Here we identified mCRC patients who did not respond to cetuximab (500 mg/m , q2w) after fluoropyrimidine/oxaliplatin regimen failure. Read More

Br J Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, St Vincent's University Hospital, Dublin, Ireland.

Obes Rev 2018 Dec 11. Epub 2018 Dec 11.

Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.

The rapid decrease in infectious diseases globally has coincided with an increase in the prevalence of obesity and other components of metabolic syndrome. Insulin resistance is a common feature of metabolic syndrome and can be influenced by genetic and non-genetic/environmental factors. The emergence of metabolic syndrome epidemics over only a few decades suggests a more prominent role of the latter. Read More

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of General Surgery, Lianshui County People's Hospital, Huai'an, China.

LncRNAs exhibit crucial roles in various pathological diseases, including hepatocellular carcinoma (HCC). Therefore, it is significant to recognize the dysregulated lncRNAs in HCC progression. Recently, LINC01133 has been identified in several tumors. Read More

Australas J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Vulval Crohn disease is rare and likely under-reported, leading to difficulty in diagnosis and delay in treatment. In this case series, we report the clinical features and discuss therapy in 26 consecutive patients with vulval Crohn disease, with or without documented gastrointestinal disease, presenting between January 2016 and July 2018. We highlight the need for treatment that is in some cases more aggressive than the requirement to manage the patient's gastrointestinal involvement. Read More

Anat Sci Educ 2018 Dec 11. Epub 2018 Dec 11.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

In the past, medical museums played a significant role in anatomy and pathology training. The attraction of medical museums has declined recently due to the emergence of information technology and innovative medical curricula. An innovative mobile learning platform has been developed using Quick Response (QR) codes for the museum specimens at the Lee Kong Chain School of Medicine, Singapore. Read More

Nurs Crit Care 2018 Dec 9. Epub 2018 Dec 9.

Nursing Department, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

Background: Previous studies have shown that feeding a high-energy formula (HF) to infants after cardiac surgery increases energy intake, with fewer side effects on cardiopulmonary function. However, impacts on weight gain and gastrointestinal function remain unclear.

Aims And Objectives: To determine the impact of HF compared with standard formula on weight gain and gastrointestinal tolerance in postoperative infants with congenital heart disease. Read More

Oncol Nurs Forum 2019 Jan;46(1):E1-E21

University of Iowa.

Problem Identification: To summarize and critique the literature for nonpharmacologic complementary approaches to manage gastrointestinal (GI) symptoms attributed to chemotherapy.

Literature Search: A literature search was conducted using CINAHL®, MEDLINE®, and PsycINFO® from database inception through January 2018.

Data Evaluation: Studies were independently appraised by each author regarding inclusion eligibility and summary of GI symptom outcomes and the nonpharmacologic complementary intervention. Read More

J Comp Eff Res 2018 Dec 14. Epub 2018 Dec 14.

Takeda Oncology, a wholly owned subsidiary of Takeda Pharmaceutical Company, Limited, 40 Landsdowne Street, Cambridge, MA 02139, USA.

Aim & methods: A retrospective study using the IBM Explorys Universe Database assessed the risk of gastrointestinal events (enterocolitis or diarrhea) among melanoma and lung cancer patients treated with ipilimumab and nivolumab combination or monotherapy. Results & conclusion: There were 904 melanoma patients (607 ipilimumab, 140 nivolumab and 157 combo) and 1641 lung cancer patients (68 ipilimumab, 1542 nivolumab and 31 combo). Approximately, 37% of lung patients and 46% of melanoma patients experienced at least one adverse event. Read More

Nutr Hosp 2018 Apr 3;35(Spec no2):27-33. Epub 2018 Apr 3.

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In order to make estimations on the evolution and near future of enteral nutrition in critically ill adult patients, we have revised the current clinical practices based on the latest guidelines for the provision and assessment of enteral nutrition support therapy. Once revised the suggested guideline recommendations we proceed to discuss the major recently published studies concerning these guidelines. Finally, we commented on several uncertainty areas highlighting priorities for clinical research in the near future. Read More

J Cardiol Cases 2016 Mar 11;13(3):87-89. Epub 2015 Dec 11.

Department of Cardiology, Leeds General Infirmary, Leeds, United Kingdom.

The combination of severe aortic stenosis, bleeding due to Heyde's syndrome and critical coronary artery disease presents a management challenge. We report the case of an 86-year-old who underwent percutaneous coronary intervention to the right coronary artery, simultaneous balloon aortic valvuloplasty to treat aortic stenosis and address bleeding from Heyde's syndrome, and subsequent staged transcatheter aortic valve implantation. < The combination of severe aortic stenosis (AS), bleeding due to Heyde's syndrome and critical coronary artery disease presents a management challenge. Read More

J Cardiol Cases 2015 Apr 22;11(4):113-116. Epub 2015 Jan 22.

Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Aspirin's efficacy for the prevention of secondary vascular disease is well supported. However, more attention should be given to its side effects, especially gastrointestinal injury. A 62-year-old man suffered acute myocardial infarction of the left main trunk. Read More

J Cardiol Cases 2014 Sep 7;10(3):104-107. Epub 2014 Jul 7.

Department of Invasive Cardiology, Medical University in Lodz, Poland.

Mesalamine has been successfully used as a maintenance treatment in inflammatory bowel diseases such as ulcerative colitis and Crohn's disease for years. Most frequent adverse reactions to this medication are gastrointestinal disorders and headaches while cardiovascular complications are rare and poorly understood. We present a case of a 26-year-old male with ulcerative colitis developing myopericarditis on mesalamine therapy. Read More

Primates 2000 Jul;41(3):291-298

Primate Research Institute, Kyoto University, Kanrin, Inuyama, 484-8506, Aichi, Japan.

A coprological survey of gastrointestinal parasites in wild Japanese macaques (Macaca fuscata), from 14 natural habitats was done. Ova of five nematode species (Trichuris trichiura, Strongyloides fuelleborni, Streptopharagus pigmentatus, Oesophagostomum aculeatum, andGongylonema species) and a worm of the cestode species,Bertiella studieri, were detected. Some differences found in rates of infection by sex were observed in the 14 areas. Read More

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

Obes Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of General Surgery, VM Mersin Medical Park Hospital, Mersin, Turkey.

Obes Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Digestive Surgery, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint-Antoine, 06200, Nice, France.

Background: Laparoscopic sleeve gastrectomy represents the most performed bariatric procedure in France. Staple line leak is the major short-term complication of the procedure. Patients with persistent fistula after sleeve gastrectomy, after failure of endoscopic and radiological treatment, are candidates for salvage surgery. Read More

Surg Case Rep 2018 Dec 13;4(1):144. Epub 2018 Dec 13.

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Gastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.

Case Presentation: An 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Read More

Front Oncol 2018 28;8:561. Epub 2018 Nov 28.

Department of Gastroenterology, University Hospital of North Norway, Tromsø, Norway.

The development of colorectal cancer (CRC) is not only determined by transformed cells , but also by factors existing in their immune microenvironment. Accumulating scientific evidence has revealed that interleukin (IL)-33, an IL-1 family member, plays an essential role in the regulation of immune response and is relevant in CRC pathogenesis. Data from both human and experimental studies demonstrated that IL-33 inhibits host anti-tumor immunity, remodels tumor stroma and enhances angiogenesis, thereby promoting the development of CRC. Read More

Cureus 2018 Oct 9;10(10):e3435. Epub 2018 Oct 9.

Radiation Oncology, Schulich School of Medicine & Dentistry - Western University, London, CAN.

Purpose To evaluate acute and late genitourinary (GU) and gastrointestinal (GI) toxicity and the biochemical control of pure hypofractionated radiotherapy (without acceleration) for the treatment of prostate cancer. Methods and materials This phase II prospective trial evaluated low-risk and intermediate-risk prostate cancer patients who received hypofractionated radiotherapy. Fifty-three patients with low-risk prostate cancer received 50 Gy in 15 fractions, 156 patients with intermediate-risk prostate cancer received 60 Gy in 20 fractions over eight weeks. Read More

J Clin Imaging Sci 2018 15;8:46. Epub 2018 Nov 15.

Division of Gastroenterology and Hepatology, University of Kentucky, College of Medicine, Lexington, Kentucky, USA.

Endoscopic intervention is well validated for the control of upper gastrointestinal bleeding (UGIB). In cases of refractory bleeding, transarterial embolization is a safe and effective alternative. Ethylene vinyl alcohol (EVOH) commonly known as Onyx is an inherently black liquid embolic approved for use in cerebrovascular arteriovenous malformations and is increasingly used as an embolic agent in multiple peripheral and visceral territories. Read More

Mol Clin Oncol 2018 Dec 4;9(6):651-655. Epub 2018 Oct 4.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Neuroendocrine tumors (NETs), belong to a group of neoplasms that arise from neuroendocrine cells and express markers such as synaptophysin and chromogranin A. The digestive system (DS) is the most common site of NET development. The World Health Organization classification divides NETs into low grade (G1-G2) tumors (NETs) and high grade carcinomas [neuroendocrine carcinomas (NECs)], based on mitotic index and histological criteria. Read More

Mol Clin Oncol 2018 Dec 1;9(6):635-639. Epub 2018 Oct 1.

Department of Oncology, University of Florence, I-50134 Florence, Italy.

The majority of patients with ovarian cancer will experience relapse and thus require second-line therapy. While platinum-based therapies are the primary treatments for refractory disease other options are required, particularly for those with partially platinum-sensitive disease as their response rates are lower. Agents that can resensitize relapsed ovarian cancers to platinum, including trabectedin, are therefore of increasing interest. Read More

Biomed Rep 2018 Dec 18;9(6):511-516. Epub 2018 Oct 18.

Department of Physiology and Biochemistry, Princess Basma Teaching Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Previous studies have shown that progesterone could inhibit muscle contraction in various sites of the gastrointestinal tract. The underlying mechanisms responsible for these inhibitory effects of progesterone are not fully known. The aim of the current study was to investigate the effect of progesterone on the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway and muscle contraction in the stomach. Read More

Oncol Lett 2018 Dec 28;16(6):7175-7179. Epub 2018 Sep 28.

Department of Gastrointestinal Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

This study investigated the role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Fifty-five patients with colon cancer who were treated in China-Japan Union Hospital of Jilin University from March 2014 to March 2015 were enrolled into this study. Their cancer and corresponding paracancerous tissues were collected and the expression levels of miR-214 were determined by RT-qPCR. Read More

Oncol Lett 2018 Dec 25;16(6):7139-7145. Epub 2018 Sep 25.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62. Read More

Pathologica 2018 Sep;110(2):111-115

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology, Policlinico Universitario-Vittorio Emanuele, University of Catania, Italy.

Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma), extraneural perineurioma does occur, frequently involving the soft tissues of the lower and upper extremities, trunk and head and neck. Rarely it has also been reported in visceral organs, including gastrointestinal tract. Read More

Nat Microbiol 2019 Jan 13;4(1):35-45. Epub 2018 Dec 13.

Department of Internal Medicine, Infectious Diseases Division, University of Michigan Medical School, Ann Arbor, MI, USA.

The human body is colonized by a diverse community of microorganisms collectively referred to as the microbiota. Here, we describe how the human microbiota influences susceptibility to infectious diseases using examples from the respiratory, gastrointestinal and female reproductive tract. We will discuss how interactions between the host, the indigenous microbiota and non-native microorganisms, including bacteria, viruses and fungi, can alter the outcome of infections. Read More

J Natl Compr Canc Netw 2018 Dec;16(12):1424-1428

Division of Surgical Oncology, Department of Surgical Pathology, Department of Medical Oncology, and Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Gastrointestinal stromal tumors (GISTs) represent 1% of alimentary tract neoplasms. Up to 90% of GISTs are driven by activating mutations in tyrosine kinase or α genes. Imatinib mesylate is a tyrosine kinase inhibitor that has recently been used in a neoadjuvant role for locally advanced GIST. Read More

Pediatrics 2018 Dec 13. Epub 2018 Dec 13.

Massachusetts General Hospital, Boston, Massachusetts; and

A healthy 17-year-old boy with a high-functioning pervasive developmental disorder presented to the emergency department after having a 4-minute episode of seizure-like activity in the setting of presumed viral gastroenteritis. Within an hour of emergency department arrival, he developed a forehead-sparing facial droop, right-sided ptosis, and expressive aphasia, prompting stroke team assessment and urgent neuroimaging. Laboratory results later revealed a serum sodium of 119 mmol/L. Read More

Cir Esp 2018 Dec 10. Epub 2018 Dec 10.

Cirugía de Pared Abdominal, Hospital Universitari Vall d'Hebron, Barcelona, España.

Background: Incisional hernias are a frequent complication, and their prevention includes proper closure of the abdominal wall.

Methods: A prospective study was conducted at a third-level hospital after the introduction of a midline laparotomy closure protocol. An objective measurement of the suture length to incision length ratio was made. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):819-824

Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Saitama, Japan.

Objective: The objective of this study was to determine the effectiveness of bevacizumab (BV) in combination with chemotherapeutic regimens for prolonging progression-free survival (PFS) as well as overall survival (OS) in patients with platinum-refractory ovarian cancer.

Materials And Methods: We retrospectively reviewed the medical records of platinum-refractory ovarian cancer patients receiving chemotherapy between January 2010 and August 2015 in the Department of Gynecology at the Saitama Medical Center, Jichi Medical University. After excluding for prior malignant disease, 57 patients were enrolled. Read More

BMC Anesthesiol 2018 Dec 13;18(1):190. Epub 2018 Dec 13.

Institute of Anaesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: Conservative obesity treatment often leads to limited results. Bariatric surgery is highly efficient, but the candidates are at risk of developing perioperative complications. Bariatric outcomes have been well described in the past, but there are only few reports of perioperative outcomes. Read More