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Addiction 2019 Feb 6. Epub 2019 Feb 6.

Department of Addictology, First Faculty of Medicine, Charles University in Prague, Czech Republic.

Background And Aims: Our understanding of the long-term safety of prenatal exposure to Opioid Maintenance Treatment (OMT) is insufficient. We compared childhood morbidity (0-3 years) between OMT-exposed and relevant comparison groups.

Design: Nation-wide, registry-based cohort study. Read More

J Mol Biol 2019 Jan 31. Epub 2019 Jan 31.

Department of Global Health, University of Washington, Seattle, WA, United States of America; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States of America; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States of America. Electronic address:

Group B Streptococcus (GBS) is a β-hemolytic Gram-positive bacterium that colonizes the lower genital tract of approximately 18% of women globally as an asymptomatic member of the gastrointestinal and/or vaginal flora. If established in other host niches, however, GBS is highly pathogenic. During pregnancy, ascending GBS infection from the vagina to the intrauterine space is associated with preterm birth, stillbirth, and fetal injury. Read More

Wiad Lek 2018 ;71(8):1541-1549

Kharkov National Medical University, Kharkiv, Ukraine.

Objective: Introduction: In children population of Ukraine the diseases of the gastrointestinal tract are quite common, among which a significant number of cases occur in liver diseases. The complexity of the liver functions formation in antenatal and intranatal periods, its morphofunctional immaturity lead to the high sensitivity of this organ to the influence of various factors from the mother organism. Actual issues are the detection of the mother's pathology influence on the formation of diseases «cargo» in children remote stages of ontogenesis. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14119

Department of Hematology, First Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, China.

Rationale: Acquired hemophilia A is a rare hemorrhagic disease in which the body produces specific antibodies that attack factor VIII, resulting in bleeding that is mainly mucocutaneous and associated with soft tissue and the gastrointestinal system. Approximately 50% of this disease derives from basic diseases, such as autoimmune diseases, cancer, and pregnancy.

Patient Concerns: We report a 35-year-old postpartum female with acquired hemophilia A who initially presented with pleural hemorrhage. Read More

Inflamm Bowel Dis 2019 Jan 8. Epub 2019 Jan 8.

Northwestern University, Feinberg School of Medicine, Chicago Illinois.

Background: Human alpha-fetoprotein (hAFP) is a glycoprotein derived from the gut entoderm and expressed sequentially by cells of the yolk sac, fetal liver, and gastrointestinal tract. By adulthood, serum levels of alpha-fetoprotein (AFP) are undetectable in healthy, nonpregnant adults. Despite the clinical utilities of AFP monitoring in pregnancy and malignancy, much remains to be determined regarding its potential physiological functions. Read More

Pan Afr Med J 2018 19;30:219. Epub 2018 Jul 19.

Service de Radiologie, Hôpital d'Enfants-Maternité Avicenne, Rabat, Maroc.

Caudal regression syndrome is a rare malformative syndrome associated, to varying degrees, with agenesis of sacral and coccygeal vertebrae, lower limb shortening and gastrointestinal, genitourinary and cardiovascular abnormalities. Its relationship with gestational diabetes is well established, but its exact cause is poorly established. We here report a rare case of caudal regression syndrome in a 8-month old infant of diabetic mother with polymalformative syndrome and chronic constipation. Read More

Pan Afr Med J 2018 16;30:212. Epub 2018 Jul 16.

Department of General and Digestive Surgery Farhat Hached Universitary Hospital, Sousse, Tunisia.

The occurrence of acute appendicitis during pregnancy may pose diagnostic and therapeutic difficulties. In fact pregnancy can make the clinical diagnosis delicate and the use of morphological examinations is still subject to controversy. The debates concerning the ideal surgical approach during pregnancy continue. Read More

Obstet Med 2018 Dec 5;11(4):178-181. Epub 2018 Jun 5.

Faculty of Medicine, University of Queensland, Brisbane, Australia.

Acute fatty liver of pregnancy is a rare complication of pregnancy that may result in fulminant hepatic failure. We present a review of all patients presenting to a quaternary obstetric hospital over a 15-year period, with particular regard to biochemical changes, results of gene testing, and pre-existing conditions. Seventeen patients with acute fatty liver of pregnancy were identified. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13707

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Eastern District, Beijing.

Rationale: Colorectal cancer (CRC) is the 2nd most common type of cancer in females and the 3rd in males, worldwide. It occurs rarely during pregnancy and is often associated with poor prognosis, due to the unspecific manifestations until advanced stage. Majority of CRC are localized in the rectum (63%) and the sigmoid colon (20%) during pregnancy. Read More

Am J Hum Biol 2018 Dec 19:e23200. Epub 2018 Dec 19.

Department of Anthropology, Yale University, New Haven, Connecticut.

Objectives: Cesarean delivery may increase childhood infectious morbidity risks via altered birth exposures and subsequent immune, microbial, and epigenetic development. Many Latin American indigenous populations experience dual burdens of infectious and chronic diseases, and are particularly vulnerable to rising rates of cesarean delivery and associated adverse outcomes. The Qom/Toba are an indigenous population in Argentina experiencing rapid lifestyle transitions. Read More

JAMA 2018 12;320(23):2438-2447

Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.

Importance: Pelvic floor disorders (eg, urinary incontinence), which affect approximately 25% of women in the United States, are associated with childbirth. However, little is known about the course and progression of pelvic floor disorders over time.

Objective: To describe the incidence of pelvic floor disorders after childbirth and identify maternal and obstetrical characteristics associated with patterns of incidence 1 to 2 decades after delivery. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13352

First Affiliated Hospital of Guangzhou University of Chinese Medicine.

Rationale: Postoperative ileus with flatulence is a common symptom in patients who have undergone cesarean section, and it can lead to peritonitis and intestinal perforation. However, few previous reports described therapeutic effects of acupuncture in women with flatulence after cesarean delivery. We reported a case of 29-year-old woman with abdominal flatulence after cesarean section. Read More

Ann Pharmacother 2018 Dec 17:1060028018817935. Epub 2018 Dec 17.

1 University of South Carolina College of Pharmacy, Columbia, SC, USA.

Objective: To review the treatment of common bacterial and viral infections occurring in the pregnant patient.

Data Sources: A literature search of MEDLINE was performed (inception to October 2018). The Centers for Disease Control and Prevention website was utilized for additional information. Read More

Mol Autism 2018 10;9:61. Epub 2018 Dec 10.

2Institute for Pediatric Regenerative Medicine and Shriners Hospitals for Children Northern California, 2504 Stockton Blvd, Sacramento, CA 95817 USA.

Background: Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota. Autism spectrum disorder (ASD) patients suffer from gastrointestinal problems and experience changes in gut microbiota; however, it is not yet clear whether the change in the microbiota associated with ASD is a cause or a consequence of the disease.

Methods: We have investigated the species richness and microbial composition in a valproic acid (VPA)-induced rat model autism. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):901-902

Department of Gastroenterology, Shaare Zedek Medical Center, Hebrew University Medical School of Jerusalem, Jerusalem, Israel.

Taiwan J Obstet Gynecol 2018 Dec;57(6):871-877

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Objective: The coexistence of maternal malignancy and pregnancy has received increasing attention in Noninvasive prenatal testing (NIPT) studies. Malignancy in pregnant women potentially affects the copy number variation (CNV) profile in NIPT results. Only one case of hematologic cancer has been reported in a Hong-Kong pregnant women, and solid tumors have never been reported in pregnant Chinese women. Read More

J Infect 2018 Dec 5. Epub 2018 Dec 5.

Reference Microbiology Services, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom; Gastrointestinal Infections Department, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom. Electronic address:

LISTERIOSIS: is a foodborne illness that can result in septicaemia, Central Nervous System (CNS) disease, foetal loss and death in high risk patients.

Objectives: To analyse the demographic trends, clinical features and treatment of non-perinatal listeriosis cases over a ten year period and identify mortality-associated risk factors.

Methods: Reported laboratory-confirmed non-pregnancy associated cases of listeriosis between 2006 and 2015 in England were included and retrospectively analysed. Read More

Radiologe 2019 Feb;59(2):126-132

Universitätsinstitut für Radiologie, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.

Background: Acute pelvic pain in women may be due to gynecological, gastrointestinal, and urinary tract disorders. Ectopic pregnancy (EP), pelvic inflammatory disease (PID), and ruptured ovarian cysts are the most common gynecological causes for acute pelvic pain and their diagnosis can be challenging.

Methods: Patient history, clinical examination, and blood tests as well as patient age and potential pregnancy status help to establish the correct diagnosis. Read More

Nat Commun 2018 11 30;9(1):5091. Epub 2018 Nov 30.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, avenue des Hauts-Fourneaux 7, 4362, Esch-sur-Alzette, Luxembourg.

The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. Read More

Vet Parasitol 2018 Dec 8;264:52-57. Epub 2018 Nov 8.

UNESP - Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, Botucatu, SP, CEP 18.618-689, Brazil.

Haemonchus contortus is an economic problem in sheep farms worldwide, mainly in the tropics and subtropics. A vaccine against haemonchosis, called Barbervax, was evaluated in ewes under two nutritional status, naturally infected with gastrointestinal nematodes. Ewes were divided into four groups: Supplemented Diet - Vaccine; Supplemented Diet - No vaccine; Basal Diet - Vaccine and Basal Diet - No vaccine. Read More

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):552-556

Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.

Background: The aim of this study was to compare the obstetric and surgical outcomes of laparoscopic appendectomy (LA) and open appendectomy (OA) performed for pregnant women at a single center. It was the hypothesis of this study that there would be no significant difference in the results.

Methods: The medical records of 57 consecutive pregnant women who underwent an appendectomy between January 2009 and September 2018 were reviewed retrospectively. Read More

World J Surg Oncol 2018 Nov 29;16(1):229. Epub 2018 Nov 29.

Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: The reports of pregnancy after total gastrectomy for gastric cancer are rare.

Case Presentation: We report a case of a 35-year-old woman, gravida 0, para 0, who became pregnant and delivered a baby 2 years and 6 months after laparoscopic-assisted total gastrectomy for early gastric cancer. Postoperatively, she showed a good progress during the follow-up and was continuously taking oral iron supplement and administered with methylcobalamin intramuscular injection. Read More

World J Gastroenterol 2018 Nov;24(42):4787-4797

Department of Dentistry and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton T6G2E1, Alberta, Canada.

Aim: To understand the effects of delivery mode on the immune cells frequency and function in cord blood and placenta.

Methods: We evaluated immunological differences in cord blood and placental tissues for a case of twins one of which delivered vaginally while the other delivered by caesarian section (C-section). Cord blood mononuclear cells were isolated and placenta tissues were processed for cell isolation. Read More

Am J Case Rep 2018 Nov 13;19:1350-1353. Epub 2018 Nov 13.

Department of Infectious Disease Pharmacy, Piedmont Columbus Regional Health, Columbus, GA, USA.

BACKGROUND Actinomyces species are normal flora of the upper respiratory, female genital, and gastrointestinal tract. Actinomyces species are generally considered to have a low virulence potential. Here we report one case of Actinomyces viscosus isolated from a neonatal blood culture as a consequence of extreme prematurity in the presence of HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. Read More

Sex Reprod Healthc 2018 Dec 18;18:30-36. Epub 2018 Aug 18.

Department of Women's and Children's Health, Karolinska Institute, Sweden.

Objective: To investigate the prevalence and severity of haemorrhoids after birth among first-time mothers in relation to management during the second stage of labour and to describe the women's experiences with haemorrhoids.

Method: A mixed method explanatory sequential design was used. Nulliparous women were allocated to an intervention group for whom the second-stage of labour practice followed the MIMA model (Midwives management during second stage of labour) or to a control group for whom standard-care practice was followed. Read More

Neuroimmunomodulation 2018 9;25(3):163-175. Epub 2018 Nov 9.

Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia.

Objectives: Gastrointestinal (GI) inflammation and GI integrity deficits are common comorbidities of neuropsychiatric disorders. Ongoing research suggests that these aberrations may be contributing to heightened immune signals that have the potential to disrupt neuronal homeostasis and exacerbate behavioural deficits. The current study aimed to determine whether the well-characterized animal model of neuropsychopathology, the maternal immune activation (MIA) model, produced GI inflammation and integrity disruptions in association with anxiety-like behaviour. Read More

Nutrients 2018 Nov 6;10(11). Epub 2018 Nov 6.

Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy.

Probiotics are living microorganisms that confer a health benefit when administered in adequate amounts. It has been speculated that probiotics supplementation during pregnancy and in the neonatal period might reduce some maternal and neonatal adverse outcomes. In this narrative review, we describe the rationale behind probiotic supplementation and its possible role in preventing preterm delivery, perinatal infections, functional gastrointestinal diseases, and atopic disorders during early life. Read More

Med Sci (Paris) 2018 Oct 7;34 Focus issue F1:47-51. Epub 2018 Nov 7.

Department of Gynecology and Obstetrics, Fujian Province Maternity and Children's Hospital, affiliated hospital of Fujian Medical University, No.18 Anshan Road, Gulou District Fuzhou City, Fujian Province 350001, PR China.

Objective: The postmenstrual bleeding with cesarean-induced diverticulum is a bothersome symptom and can be confused with other abnormal-uterine bleeding disease. The aim of the present study was to evaluate the efficacy and safety of laparoscopic combined with hysteroscopic repair vs operative hysteroscopy in treatment of symptomatic cesarean-induced diverticulum.

Methods: Eighty-two women with cesarean-induced diverticulum who underwent either laparoscopic combined with hysteroscopic repair or operative hysteroscopy between January 2012 and September 2015 were retrospectively included in the study. Read More

Ulus Travma Acil Cerrahi Derg 2018 Sep;24(5):423-428

Department of General Surgery, Ordu University Faculty of Medicine, Ordu-Turkey.

Background: Acute appendicitis (AA) is the most common emergency surgical condition during pregnancy after obstetric and gynecological pathologies. Urgent and accurate diagnosis of AA in pregnant patients reduces maternal and fetal morbidity/mortality rates. This study evaluated the significance of hemogram to diagnose AA during pregnancy. Read More

Med Lett Drugs Ther 2018 Sep 10;60(1555):e152-e153. Epub 2018 Sep 10.

J Intern Med 2018 Oct 29. Epub 2018 Oct 29.

Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects younger individuals 15-45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0. Read More

Biosci Microbiota Food Health 2018 10;37(4):79-85. Epub 2018 Aug 10.

Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.

The gastrointestinal tract is believed to be colonized rapidly with bacteria immediately from birth. The source of these intestinal microbes is an ongoing topic of interest because increasing evidence suggests that the composition of the initial intestinal bacterial colonization strongly affects health. In particular, the source of bifidobacteria has received marked attention because these bacteria are suggested to play a crucial role in protecting against susceptibility to diverse diseases later in life. Read More

Nat Commun 2018 10 26;9(1):4462. Epub 2018 Oct 26.

Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, 80045, CO, USA.

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant gut by microbes plays a critical role in establishing immunity and metabolic function. Here, we compare germ-free mice colonized with stool microbes (MB) from 2-week-old infants born to obese (Inf-ObMB) or normal-weight (Inf-NWMB) mothers. Read More

BMC Pregnancy Childbirth 2018 Oct 19;18(1):407. Epub 2018 Oct 19.

Department of Gynecology, Xinhua Hospital affiliated with Shanghai Jiaotong University, 1665 Kong Jiang Rd, Yang Pu District, Shanghai, 200092, China.

Background: Although vaginal repair has been conducted to manage caesarean scar diverticula, most studies evaluated only the gynaecological outcomes post-surgery, and their obstetrical outcomes were unknown. This study aimed to evaluate the obstetrical outcomes in vaginal repair-treated caesarean scar diverticula patients.

Methods: A series of 51 symptomatic women with caesarean scar defects or a thickness of the remaining muscular layer of less than 3 mm according to transvaginal ultrasound were included. Read More

N Engl J Med 2018 Oct;379(16):1562-1570

From the Departments of Medicine (J.E.M., J.W.C.), Radiology (K.S.), Obstetrics and Gynecology (L.E.R.), and Pathology (K.M.B.), Massachusetts General Hospital, and the Departments of Medicine (J.E.M., J.W.C.), Radiology (K.S.), Obstetrics and Gynecology (L.E.R.), and Pathology (K.M.B.), Harvard Medical School - both in Boston.

Aliment Pharmacol Ther 2018 Nov;48(9):1017-1018

Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Niger J Clin Pract 2018 Oct;21(10):1368-1373

Department of Paediatrics, Obstetrics and Gynaecology and Medical Microbiology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.

Background: : Intestinal helminthiasis is a major public health problem in Africa. Helminthic infection in pregnant women causes loss of appetite, poor nutrient absorption, gastrointestinal impairment, iron deficiency, and iron deficiency anemia resulting in low birth weights and preterm births. The main aim of this study is to assess the prevalence of helminthic infections in pregnant women in rural and peri-urban communities of Ibadan. Read More

Vet Immunol Immunopathol 2018 Oct 26;204:59-64. Epub 2018 Sep 26.

Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, SK, S7N 5E3, Canada; School of Public Health, University of Saskatchewan, SK, S7N 2Z4, Canada. Electronic address:

Recent next generation sequencing studies on host-associated microbiomes generated debatable conclusions regarding the central dogma of fetal gut sterility. These observations challenge the concepts that microbial colonization of the gut begins during and after birth as well as the concept of antigen-independent prenatal maturation of mucosal-associated lymphoid tissue in ruminants and humans. The placental barrier varies markedly among mammalian species with mice and humans having haemochorial placentas (fetal tissue in direct contact with maternal blood) versus epitheliochorial placentation (maternal and fetal blood separated by six tissue layers) in ruminants. Read More

Life Sci 2018 Nov 2;212:176-181. Epub 2018 Oct 2.

Department of Clinical Pharmacology, King Edward Memorial Hospital, Seth GS Medical College, Mumbai 400013, India.

Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract that is usually associated with chronic abdominal pain and altered bowel habits. The two spectra of the disease include constipation-predominant IBS and Diarrhea-predominant IBS. Earlier it was thought to be an unexplained brain-gut disorder, but of late, various underlying causes suggesting primary gut disturbance have been identified. Read More

Cochrane Database Syst Rev 2018 10 5;10:CD003106. Epub 2018 Oct 5.

Department of Obstetrics and Gynaecology, The Royal Wolverhampton Hospitals NHS Trust, New Cross Hospital, Wednesfield, Wolverhampton, West Midlands, UK, WV10 0QP.

Background: Severe pre-eclampsia can cause significant mortality and morbidity for both mother and child, particularly when it occurs remote from term, between 24 and 34 weeks' gestation. The only known cure for this disease is delivery. Some obstetricians advocate early delivery to ensure that the development of serious maternal complications, such as eclampsia (fits) and kidney failure are prevented. Read More

J Crohns Colitis 2019 Feb;13(2):230-244

Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Background And Aims: CD71+ erythroid cells are enriched during pregnancy with immuno suppressive properties. We investigated the frequency and functionality of CD71+ erythroid cells in peripheral blood, cord blood, and placenta of inflammatory bowel disease [IBD] patients versus healthy controls [HCs]. We aimed to determine their role in IBD pathogenesis during pregnancy. Read More

Surg Clin North Am 2018 Oct 7;98(5):945-971. Epub 2018 Aug 7.

Carilion Clinic and Virginia Tech Carilion School of Medicine, Carilion Clinic Department of Surgery, 1906 Belleview Avenue, Med. Ed., 3rd Floor, Suite 332, Roanoke, VA 24014, USA.

Identifying patients with small bowel obstruction who need operative intervention and those who will fail nonoperative management is a challenge. Without indications for urgent intervention, a computed tomography scan with/without intravenous contrast should be obtained to identify location, grade, and etiology of the obstruction. Most small bowel obstructions resolve with nonoperative management. Read More

Genome Res 2018 10 19;28(10):1467-1480. Epub 2018 Sep 19.

March of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.

Recent studies suggest that the microbiome has an impact on gestational health and outcome. However, characterization of the pregnancy-associated microbiome has largely relied on 16S rRNA gene amplicon-based surveys. Here, we describe an assembly-driven, metagenomics-based, longitudinal study of the vaginal, gut, and oral microbiomes in 292 samples from 10 subjects sampled every three weeks throughout pregnancy. Read More

J Gynecol Obstet Hum Reprod 2018 Dec 16;47(10):577-579. Epub 2018 Sep 16.

Pôle Femme Et Enfant, CHU Estaing, 1, place Lucie-et-Raymond-Aubrac, 63003 Clermont-Ferrand Cedex 1, France; Equipe "Translational approach to epithelial injury and repair", Université Clermont-Auvergne, CNRS, Inserm, GReD, 63000 Clermont-Ferrand, France. Electronic address:

A laryngotracheoesophageal cleft, commonly called laryngeal cleft (LC), is a congenital malformation of the posterior part of the larynx creating an abnormal communication between the laryngotracheal axis and the pharyngoesophageal axis. The prenatal ultrasonographic features associating absent stomach, polyhydramnios and mediastinal "pouch sign" are usually considered pathognomonic for esophageal atresia. This observation demonstrates that they can also correspond to a severe form of laryngotracheoesophageal cleft extending to the carina. Read More

Osteoporos Int 2018 Sep 6. Epub 2018 Sep 6.

Division of Orthopaedic Surgery and Sports Medicine, Children's National Health System, Washington, DC, USA.

There is limited research which examines health concerns of individuals with osteogenesis imperfecta (OI). Discussion groups with leaders of the adult OI community identified a broad range of medical priorities beyond fractures and brittle bones. Our work underscores the need to include patient-reported outcomes in rare bone disease research. Read More

Am Surg 2018 Aug;84(8):1326-1328

Appendectomy for presumed appendicitis is the most common surgical emergency during pregnancy. Delayed diagnosis and treatment of appendicitis carries risk for the fetus and mother. We sought to evaluate the accuracy of MRI in pregnant patients with suspected appendicitis. Read More

J Addict Nurs 2018 Jul/Sep;29(3):205-210

Gina Dobbs, DNP, MSN, FNP-BC, CRNP, University of Alabama at Birmingham. Susanne A. Fogger, DNP, CRNP, PMHNP-BC, CARN-AP, FAANP, School of Nursing, University of Alabama at Birmingham.

The worsening opioid epidemic ignites infectious disease development and transmission as opioids abused by insufflation and/or injection establish a pathway for infection to the user and propagate vulnerability to diseases. The phenomenon of the synergistic collision of epidemics intensifying the load of disease constitutes a syndemic. Merrill Signer (1994) voiced the term "syndemic" to characterize the complex nexus of politics, economics, psychosocial/environmental factors, and health disparities resulting in the inner-city AIDS crisis of the 1990s. Read More

Eur J Clin Microbiol Infect Dis 2018 Dec 3;37(12):2293-2299. Epub 2018 Sep 3.

Service de Biologie, Unité de Microbiologie, Centre Hospitalier de Versailles, Le Chesnay, France.

Our aim was to study Clostridium difficile infection (CDI) in peripartum women in France and compare them to cases published in the literature. We characterize these infections regarding clinico-biological features and specific risk factors in order to raise awareness for obstetricians and midwifes. Eight antepartum and six post-partum CDI cases were retrospectively studied in 6 French centers during the period between 2008 and 2013. Read More