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Obes Surg 2022 May 21. Epub 2022 May 21.

Gastrointestinal Surgery Centre, Mansoura University, Mansoura, Egypt.

Purpose: Prediction of the onset of de novo gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG) would be helpful in decision-making and selection of the optimal bariatric procedure for every patient. The present study aimed to develop an artificial intelligence (AI)-based model to predict the onset of GERD after SG to help clinicians and surgeons in decision-making.

Materials And Methods: A prospectively maintained database of patients with severe obesity who underwent SG was used for the development of the AI model using all the available data points. Read More

PLoS One 2022 20;17(5):e0267053. Epub 2022 May 20.

Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.

Background And Aim: Gastroesophageal reflux disease (GERD) typically presents with symptoms of heartburn and acid regurgitation but occasionally manifests as atypical chest pain. Coronary artery disease (CAD) and GERD share some risk factors, such as smoking and obesity. The aims of this study were to evaluate the association between GERD and coronary atherosclerosis and to assess the risk factors for coronary atherosclerosis in GERD patients. Read More

Am Surg 2022 May 20:31348221093800. Epub 2022 May 20.

Department of Surgery, Atrium Health Navicent, Macon Georgia, 12241Mercer University School of Medicine, Macon GA, USA.

Gastroesophageal reflux disease (GERD) is the retrograde flow of gastric contents into the distal esophagus and may be treated medically or surgically. Magnetic sphincter augmentation surgery using LINX has recently demonstrated comparable results to Nissen fundoplication. We aimed to evaluate preoperative patient risk factors that were associated with LINX removal rates or postoperative EGD with dilation rates (POEGDD). Read More

Neurogastroenterol Motil 2022 May 20:e14412. Epub 2022 May 20.

Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Background: Hiatus hernia (HH) contributes to development of gastroesophageal reflux disease, Barrett's esophagus and esophageal adenocarcinoma. This study was aimed to investigate the influence of HH on reflux patterns and distal esophageal mucosal integrity in non-erosive reflux disease (NERD).

Methods: We retrospectively analyzed PPI-refractory NERD patients referred to three tertiary referral centers who underwent high-resolution manometry and off-PPI 24-h impedance-pH monitoring (with or without bile spectrophotometry). Read More

Eur Rev Med Pharmacol Sci 2022 May;26(9):3127-3131

Department of Gastroenterology, Advanced Endoscopic Procedures Unit, Hisar Intercontinental Hospital, Galata University, Galata, Turkey.

Objective: Cervical Inlet Patch (CIP) is an interesting entity that is little known and often neglected by endoscopists. It has always been reported as less than expected. In this article, for the first time in the literature, we want to measure the true prevalence of CIP in a center dealing with specific esophageal diseases. Read More

Evid Based Complement Alternat Med 2022 9;2022:7464147. Epub 2022 May 9.

Institute of Respiratory Diseases, The First Hospital of China Medical University, Shenyang City, Liaoning Province, China.

Background: To investigate the beneficial effect of berberine on gastroesophageal reflux-induced airway hyperresponsiveness (GERAHR) and explore the underlying mechanism.

Methods: Coword cluster analysis and strategic coordinates were used to identify hotspots for GERAHR research, and an online tool (STRING, https://string-db.org/) was used to predict the potential relationships between proteins. Read More

J Scleroderma Relat Disord 2022 Jun 20;7(2):128-134. Epub 2022 Mar 20.

Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, USA.

Objective: Pulmonary manifestations of systemic sclerosis are a major cause of morbidity and mortality. Small airways disease can cause dyspnea and pulmonary function test abnormalities. We aimed to determine the prevalence of small airways disease and describe the characteristics associated with small airways disease in a cohort of systemic sclerosis patients. Read More

J Scleroderma Relat Disord 2022 Jun 23;7(2):117-127. Epub 2021 Oct 23.

Department of Medicine, Pulmonary & Critical Care, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Objective: To explore the presence of small airway disease (SAD) and emphysema in scleroderma-related interstitial lung disease (SSc-ILD) and to evaluate the physiologic and clinical correlates of SAD in SSc-ILD.

Methods: Thoracic high-resolution computed tomography (HRCT) images obtained from the Scleroderma Lung Study II (SLSII) participants were reviewed by a group of thoracic radiologists. The presence of SAD was assessed by visual assessment for air trapping. Read More

J Scleroderma Relat Disord 2022 Jun 10;7(2):135-143. Epub 2022 Apr 10.

Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

Objective: Certain Hispanic/Latino (Hispanic) populations have been reported to have higher rates and severity of systemic sclerosis; however, little is known of systemic sclerosis in the American Southwest. This study compared manifestations of systemic sclerosis in Hispanics with non-Hispanics of New Mexico.

Methods: This cross-sectional longitudinal study included 109 systemic sclerosis patients followed over a mean of 12. Read More

BMC Gastroenterol 2022 May 18;22(1):253. Epub 2022 May 18.

Department of Gastroenterology, The Seventh Medical Center of PLA General Hospital, Nanmencang 5#, Dongcheng District, Beijing, 100700, China.

Background: Achalasia is a rare primary esophageal motility disorder disease. It is reported that the long-term effect of fully coated anti-reflux metal stent (FCARMS) implantation is satisfactory. Operated by a skilled and experienced endoscopist, the effect of per-oral endoscopic myotomy (POEM) treatment is equivalent to that of surgical myotomy. Read More

Hepatol Res 2022 May 18. Epub 2022 May 18.

Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.

Aim: Reflux esophagitis is associated with metabolic dysfunction. Recently, fatty liver has been redefined as metabolic dysfunction-associated fatty liver disease (MAFLD). We investigated the impact of MAFLD and its subtypes on the incidence of reflux esophagitis. Read More

Langenbecks Arch Surg 2022 May 18. Epub 2022 May 18.

Department of Biomedical Science for Health, Division of General Surgery, University of Milan, Istituto Clinico Sant'Ambrogio, Via Luigi Giuseppe Faravelli, 16, 20149, Milan, Italy.

Background: Different methods have been described for laparoscopic hiatoplasty and hiatus hernia (HH) repair. All techniques are not standardized and the choice to reinforce or not the hiatus with a mesh is left to the operating surgeon's preference. Hiatal surface area (HSA) has been described as an attempt at standardization; in case the area is > 4 cm, a mesh is used to reinforce the repair. Read More

Surg Laparosc Endosc Percutan Tech 2022 Apr 22. Epub 2022 Apr 22.

Department of Medical Statistics and Informatics, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Purpose: Laparoscopic proximal gastrectomy (LPG) has been a standard surgery for early gastric cancer in the upper third of the stomach and large esophagogastric junction gastrointestinal stromal tumor. However, how to reconstruct the stomach after LPG is still debated. This study aimed to evaluate the results of LPG with double-flap reconstruction. Read More

Surg Laparosc Endosc Percutan Tech 2022 Apr 19. Epub 2022 Apr 19.

Türkçapar Bariatrics, Obesity Center.

Aim: The aim of this study is to reveal incidence of gastroesophageal reflux disease (GERD) after laparoscopic sleeve gastrectomy (LSG) and to determine the effect of LSG with hiatal hernia repair on GERD.

Methods: A total of 440 patients, 395 of them underwent primary LSG (group A) and 45 of them underwent LSG with concomitant hiatal hernia repair (group B) between March 2018 and September 2020 were included in the study. Presence of hiatal hernia was evaluated with endoscopy and confirmed intraoperatively. Read More

Ann Med 2022 Dec;54(1):1372-1384

Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.

Background: Because trends in the epidemiology and burden of gastroesophageal reflux disease (GERD) are changing, reinvestigating the geographical differences and trend changes is essential. Here we evaluated the latest epidemiologic patterns and trends for GERD, using data from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.

Methods: Annual case numbers, age-standardized rates of prevalence, incidence, and years of life lived with disability (YLDs), and their estimated annual percentage changes (EAPCs) for GERD between 1990 and 2019 were derived from the GBD 2019 study. Read More

Mol Med 2022 May 16;28(1):57. Epub 2022 May 16.

Institute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.

Background: Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical course of COVID-19. Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Read More

Hernia 2022 May 16. Epub 2022 May 16.

Department of Biomedical Science for Health, Division of General Surgery, University of Milan, Istitituto Clinico Sant'Ambrogio, Milan, Italy.

Background: Paraesophageal hiatal hernia (PEH) is characterized by protrusion of intra-abdominal organs into the posterior mediastinum. Respiratory symptoms and reduced pulmonary function have been described as possibly related to lung compression.

Objective: To assess the effect of laparoscopic Toupet fundoplication (LTF) for PEH repair on pulmonary function, measured with pulmonary function tests (PFTs), and respiratory symptoms. Read More

BMJ Case Rep 2022 May 16;15(5). Epub 2022 May 16.

Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Oesophageal diverticulum occurring secondary to motility disorders or gastro-oesophageal reflux disease (GERD) is common in adults but true congenital oesophageal diverticula are rare in infants and children. We present a case of a toddler boy who presented with dysphagia and vomiting after feeds after weaning was attempted starting at 6 months of age. Barium esophagogram revealed a diverticulum in the upper one-third of the oesophagus within the thoracic cavity. Read More

Obes Surg 2022 May 16. Epub 2022 May 16.

Department of Biomedical Science for Health, Division of General Surgery, Istitituto Clinico Sant'Ambrogio, University of Milan, Via Luigi Giuseppe Faravelli, 16, 20149, Milan, Italy.

Cureus 2022 Apr 12;14(4):e24082. Epub 2022 Apr 12.

Family Medicine, Lake Erie College of Osteopathic Medicine, Jacksonville, USA.

This case report details a rare case of Grover's disease in an 80-year-old Caucasian male complaining of a rash across his chest over the last three to four months. The patient has a past medical history of essential hypertension, hyperlipidemia, osteoarthritis of the knee, chronic gastroesophageal reflux disease (GERD), supraventricular tachycardia, status post prostate cancer, and restless legs syndrome. During his initial evaluation, he was found to have a pruritic, erythematous, papular rash most notably along his upper trunk and chest. Read More

Cureus 2022 Apr 13;14(4):e24122. Epub 2022 Apr 13.

Research, Retired, McKean, USA.

A novel exercise is described for resistance training of the lower esophageal sphincter. Resistance is provided by gravity as food is swallowed and pushed up an incline into the stomach. The incline is established by kneeling with the head bowed lower than the stomach. Read More

Asian J Surg 2022 May 12. Epub 2022 May 12.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Although proximal gastrectomy (PG) is a function-preserving surgical option, it remains unclear as to which reconstruction method can prevent reflux and maintain body composition.

Methods: Patients who underwent PG at Keio University between April 2011 and November 2018 were analyzed. Changes in the subcutaneous and visceral adipose tissues were comparatively assessed before and after a year of surgery for three common reconstruction methods. Read More

Ann Allergy Asthma Immunol 2022 May 12. Epub 2022 May 12.

Merck & Co., Inc., Kenilworth, NJ, USA.

Background: Current characterization of patients with refractory or unexplained chronic cough (RCC and UCC, respectively) primarily stems from relatively small clinical studies.

Objective: To report the baseline medical history and clinical characteristics of individuals with RCC or UCC enrolled in COUGH-1 and COUGH-2, two large, global, phase 3 trials of gefapixant, a P2 × 3-receptor antagonist.

Methods: Adults with a chronic cough lasting ≥1 year, diagnosis of RCC or UCC, and score of ≥40 mm on a 100-mm cough severity visual analog scale (VAS) at both screening and baseline were eligible for enrollment. Read More

Int J Surg 2022 May 12;102:106662. Epub 2022 May 12.

Department of Surgery, Minia University Hospital, Egypt.

Background: Santoro's operation is a sleeve gastrectomy with transit bipartition. The operation aims to maintain passage to the duodenum to minimize nutritional deficiency. This procedure is rapidly changed to single anastomosis sleeve ileal (SASI) bypass. Read More

Nutrients 2022 Apr 22;14(9). Epub 2022 Apr 22.

Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok 10330, Thailand.

A randomized crossover study in eight patients (6 F, age 57 ± 13) with overlapping GERD-IBS (non-constipation) was conducted to evaluate the effects of rice noodle vs. wheat noodle meals for breakfast and lunch on postprandial TLESR, intestinal gas production, and GERD/GI symptoms. Results: Wheat ingestion was significantly associated with more frequent TLESR after lunch than rice (5. Read More

Int J Environ Res Public Health 2022 Apr 30;19(9). Epub 2022 Apr 30.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Wintrobe 701, Salt Lake City, UT 84132, USA.

Obstructive sleep apnea (OSA) is a highly prevalent disorder that has profound implications on the outcomes of patients with chronic lung disease. The hallmark of OSA is a collapse of the oropharynx resulting in a transient reduction in airflow, large intrathoracic pressure swings, and intermittent hypoxia and hypercapnia. The subsequent cytokine-mediated inflammatory cascade, coupled with tractional lung injury, damages the lungs and may worsen several conditions, including chronic obstructive pulmonary disease, asthma, interstitial lung disease, and pulmonary hypertension. Read More

Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.

Background: Gastroesophageal reflux disease (GERD) may present as nonerosive reflux disease (NERD), erosive esophagitis (EE), or be complicated by Barrett's esophagus (BE). The explanation as to what determines the phenotype of GERD is awaited. Therefore, we assessed the correlation between the growth factors expression and endoscopic as histologic findings in GERD patients. Read More

Saudi J Gastroenterol 2022 May-Jun;28(3):168-174

Department of Anatomy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Belching is defined as an audible escape of air from the esophagus or the stomach into the pharynx. It becomes pathologic if it is excessive and becomes bothersome. According to Rome IV diagnostic criteria, there is a belching disorder when one experiences bothersome belching (severe enough to impact on usual activities) more than 3 days a week. Read More

Mod Rheumatol 2022 May 12. Epub 2022 May 12.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: The concept of locomotive syndrome was proposed to highlight older adults who require nursing care services due to the malfunctioning of their locomotive organs. With the coming of a super-aging society, there is a growing need to understand relation between systemic chronic diseases and locomotive syndrome.

Methods: We analyzed the second-visit dataset of the Nagahama Study. Read More