33,010 results match your criteria Gastroesophageal Reflux Disease


Gastroesophageal Reflux Disease-Functional Dyspepsia Overlap: Do Birds of a Feather Flock Together?

Am J Gastroenterol 2020 May 25. Epub 2020 May 25.

Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (ChroMetA), University of Leuven, Leuven, Belgium.

Introduction: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) are 2 of the most prevalent upper gastrointestinal (GI) disorders in the Western world. Previous Rome definitions excluded patients with predominant heartburn from the definition of FD because they were considered to have GERD. However, more recent studies showed that heartburn and acid regurgitation are also common symptoms in patients with FD. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000619DOI Listing

Role of antioxidants in the treatment of gastroesophageal reflux disease-associated idiopathic pulmonary fibrosis.

Curr Opin Pulm Med 2020 May 20. Epub 2020 May 20.

Campus Venlo, Maastricht University, Maastricht, The Netherlands.

Purpose Of The Review: Idiopathic pulmonary fibrosis (IPF) is a terminal lung disease of largely unknown cause. Gastroesophageal reflux disease (GERD) was recently discovered to be a trigger for the development of IPF. The current pharmaceutical approach to IPF falls short and there is a pressing need for improved therapeutic options. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000684DOI Listing

Use of ketogenic diet therapy in infants with epilepsy: A systematic review and meta-analysis.

Epilepsia 2020 May 26. Epub 2020 May 26.

UCL Great Ormond Street Institute of Child Health, London, UK.

Objective: Ketogenic diet therapy (KDT) is a group of high-fat, low-carbohydrate diets used as an effective treatment option for children and adults with drug-resistant epilepsy. There is limited research on the efficacy of KDT in infants, where there is the highest incidence of onset of the epilepsy. We aimed to systematically review studies that have reported on response to KDT in infants with epilepsy. Read More

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http://dx.doi.org/10.1111/epi.16543DOI Listing

Gastroesophageal Reflux Poses a Potential Risk for Late Complications of Bronchopulmonary Dysplasia: A Prospective Cohort Study.

Chest 2020 May 22. Epub 2020 May 22.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, P.R.China. Electronic address:

Background: Bronchopulmonary dysplasia (BPD) is the most common respiratory disorder in extremely low birth weight infants. Although most BPD symptoms improve, some late complications exist, even with regular treatment. Gastroesophageal reflux (GER), also common in extremely premature infants, may be related to many cardiorespiratory symptoms. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.523DOI Listing

Pediatric gastroesophageal reflux disease in primary care: Evaluation and care update.

Curr Probl Pediatr Adolesc Health Care 2020 May 21:100784. Epub 2020 May 21.

Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Dayton Children's Hospital, Boonshoft School of Medicine, Wright State University, Dayton, OH 45404, United States.

Gastroesophageal reflux disease (GERD) is a pathologic form of the common process of reflux. This paper reviews the evaluation and care of GERD in children for primary care clinicians. Special attention is paid to the variations in evaluation and care for infants and for older children based on the most recent pediatric guidelines for Europe and North America. Read More

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http://dx.doi.org/10.1016/j.cppeds.2020.100784DOI Listing

Provider Variability in the Management Patterns of Increased Nonacid Reflux.

Dig Dis Sci 2020 May 23. Epub 2020 May 23.

Division of Gastroenterology, University of Michigan Hospitals-Michigan Medicine, 3912 Taubman Center, 1500 E Medical Center Dr., SPC 5362, Ann Arbor, MI, 48109, USA.

Introduction: Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be varied and unclear.

Aims: Our primary aim was to investigate physician management patterns for patients who had received a diagnosis of increased nonacid reflux on impedance-pH studies. Read More

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http://dx.doi.org/10.1007/s10620-020-06348-6DOI Listing

Age and Upper Airway Obstruction: A Challenge to the Clinical Approach in Pediatric Patients.

Int J Environ Res Public Health 2020 May 18;17(10). Epub 2020 May 18.

Division of Neonatology and Neonatal Intensive Care Unit, "F. Del Ponte" Hospital, 21100 Varese, Italy.

Upper airway abnormalities increase the risk of pediatric morbidity in infants. A multidisciplinary approach to obstructive sleep apnea syndrome (OSAS) poses challenges to clinical practice. The incidence and causes of OSA are poorly studied in children under 2 years of age. Read More

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http://dx.doi.org/10.3390/ijerph17103531DOI Listing

Viscosity of Commercial Food-based Formulas and Home-prepared Blenderized Feeds.

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):e124-e128

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA.

Objective: The aim of the study was to quantify the differences in viscosity of over a range of commercial food-based formulas and home-prepared blenderized feeds used for enteral feeding in the clinical management of gastroesophageal reflux and gastroesophageal reflux-related aspiration in children with oropharyngeal dysphagia.

Methods: The viscosity of commercial and home blends was measured using digital rotational viscometer and International Dysphagia Diet Standardization Initiative Syringe Flow Test. Additional testing was performed to determine the impact of added cereal, water flushes, and freezing/thawing on formula viscosity. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002657DOI Listing

Children With Gastroesophageal Reflux Disease Consume More Calories and Fat Compared to Controls of Same Weight and Age.

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):808-814

Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.

Objective: The aim of the study was to compare the rates of nutrients consumption in children and adolescents with gastroesophageal reflux disease (GERD) compared to the control group without the disease.

Methods: Based on symptom evaluation and esophageal pH-impedance recordings patients were allocated on to GERD and control groups. All patients underwent esophagogastroscopy. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002652DOI Listing

Children With Gastroesophageal Reflux Disease Consume More Calories and Fat Than Controls.

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):761-762

Pediatric Intermediate Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.

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http://dx.doi.org/10.1097/MPG.0000000000002656DOI Listing

Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways.

Expert Rev Gastroenterol Hepatol 2020 May 22:1-9. Epub 2020 May 22.

Department of Medicine and Surgery, University of North Carolina, Chapel Hill, NC, USA.

: Increases in the rates of esophageal adenocarcinoma (EAC) have paralleled rises in the prevalence of overweight and obesity. Despite not being fully understood, obesity-related EAC seems to have different carcinogenic pathways.: This comprehensive review will thoroughly evaluate the current literature, describing the underlying mechanisms that help understanding the strong association between obesity and esophageal cancer. Read More

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http://dx.doi.org/10.1080/17474124.2020.1764348DOI Listing

Laparoscopic management of a late gastric perforation post-fundoplication.

J Surg Case Rep 2020 May 18;2020(5):rjz195. Epub 2020 May 18.

Metabolic and Bariatric Surgery, Lakes Region General Hospital, Clinical Assistant Professor of Surgery, University of New England College of Osteopathic Medicine.

Nissen fundoplication is a safe and effective procedure for gastroesophageal reflux. Gastric ulceration leading to perforation is an uncommon late complication with a mechanism of action that is poorly understood. A 40-year-old male presented 3 years following his fundoplication with a perforated ulcer in the upper body of the stomach. Read More

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http://dx.doi.org/10.1093/jscr/rjz195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232994PMC

Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related.

Gut 2020 May 21. Epub 2020 May 21.

Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: After treatment, achalasia patients often develop reflux symptoms. Aim of this case-control study was to investigate mechanisms underlying reflux symptoms in treated achalasia patients by analysing oesophageal function, acidification patterns and symptom perception.

Design: Forty treated achalasia patients (mean age 52. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-320772DOI Listing

Gastroesophageal Reflux Disease in the Neonatal Intensive Care Unit Neonate: Controversies, Current Understanding, and Future Directions.

Clin Perinatol 2020 Jun 19;47(2):243-263. Epub 2020 Feb 19.

Innovative Infant Feeding Disorders Research Program, Nationwide Children's Hospital, Center for Perinatal Research, Abigail Wexner Research Institute, 575 Children's Crossroads, Columbus, OH 43215, USA; Division of Neonatology, Nationwide Children's Hospital, Columbus, OH, USA; Division Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, College of Medicine, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address:

Gastroesophageal reflux (GER) is considered physiologic and is a normal process; whereas, when aerodigestive consequences are associated, it is often interpreted as GER disease (GERD). However, the distinction between them remains a challenge in infants in the NICU. Reflux-type of symptoms are heterogeneous, and often managed with changes in diet, feeding methods, and acid-suppressive therapy; all these empiric therapies lack objectivity; hence, practice variation is universal. Read More

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http://dx.doi.org/10.1016/j.clp.2020.02.004DOI Listing

Neonatal Aerodigestive Disorders: Epidemiology and Economic Burden.

Clin Perinatol 2020 Jun 19;47(2):211-222. Epub 2020 Feb 19.

Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Division of Neonatology, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA. Electronic address:

Aerodigestive disorders, those affecting the upper and lower airway or upper gastrointestinal tract, are interrelated anatomically during fetal development and functionally after birth. Successful respiration and feeding requires careful coordination to promote effective swallowing and prevent aspiration. I describe the epidemiology, including the prevalence of the most common aerodigestive disorders. Read More

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http://dx.doi.org/10.1016/j.clp.2020.02.003DOI Listing

Hypopharyngeal-Esophageal Impedance-pH Monitoring Profiles of Laryngopharyngeal Reflux Patients.

Laryngoscope 2020 May 21. Epub 2020 May 21.

Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.

Objectives/hypothesis: To investigate the profile of patients with laryngopharyngeal reflux (LPR) at hypopharyngeal-esophageal multichannel intraluminal impedance-pH (HEMII-pH) monitoring and the relationship between hypopharyngeal-proximal reflux episodes (HREs) and saliva pepsin concentration.

Study Design: Prospective non-controlled.

Methods: Patients were recruited from three European hospitals from January 2018 to October 2019. Read More

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http://dx.doi.org/10.1002/lary.28736DOI Listing

Nissen fundoplication in Cornelia de Lange syndrome spectrum: Who are the potential candidates?

Am J Med Genet A 2020 May 21. Epub 2020 May 21.

Department of Pediatrics, ASST-Lariana, "Sant'Anna" Hospital, Como, Italy.

Cornelia de Lange spectrum (CdLSp) is a rare genetic condition characterized by intellectual disability, facial dysmorphisms, major malformations, growth impairment, and development delay. Approximately 80% of CdLSp patients have gastroesophageal reflux disease (GERD) with a varied clinical presentation. The aim of this study is to define potential clinical/genetic risk factors based on the clinical phenotype description of CdLSp patients with severe GERD who underwent surgical treatment. Read More

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http://dx.doi.org/10.1002/ajmg.a.61625DOI Listing

Peer-Led Education Expedites Deprescribing Proton Pump Inhibitors for Appropriate Veterans.

Authors:
Mary H Bowman

Gastroenterol Nurs 2020 May 18. Epub 2020 May 18.

Mary H. Bowman, DNP, FNP-C, APRN, is Primary Care Provider, San Diego VA HealthCare System, San Diego, California.

Costly proton pump inhibitors have been widely prescribed since the 1990s for prevention and treatment of ulcers and gastroesophageal reflux disease. Evidence published since 2012 demonstrates risks associated with taking proton pump inhibitors for longer than 8 weeks. Primary care providers mostly deprescribe proton pump inhibitors for persons not meeting criteria for long-term use. Read More

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http://dx.doi.org/10.1097/SGA.0000000000000479DOI Listing

Mitral Valve Aneurysm in Mitral Valve Endocarditis:A Case Report.

Am J Med Case Rep 2020 19;8(3):83-87. Epub 2020 Jan 19.

Division of Cardiovascular Diseases and Department of Internal Medicine, State University of New York, Downstate Medical Center, Health Sciences University, Brooklyn NY 11203, USA.

Mitral valve aneurysm (MVA) is an ominous complication of infective endocarditis (IE), with worse outcomes seen among patients with preexisting valvular disease or intravenous drug use. Valve aneurysms can perforate or lead to rupture of the chordae tendineae, with the consequent development of severe mitral regurgitation and acute pulmonary edema. We present a case of a 54-year-old woman with hypertension, obesity, diabetes mellitus, hyperlipidemia, chronic obstructive pulmonary disease, peptic ulcer disease, obstructive sleep apnea, gastroesophageal reflux disease, intravenous drug abuse and bipolar disorder who developed MVA one month after being discharged for IE. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237018PMC
January 2020

[Painful orbital swelling in a 61-year-old female patient].

Internist (Berl) 2020 May 19. Epub 2020 May 19.

Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, HELIOS Klinikum Krefeld, Lutherplatz 40, 47805, Krefeld, Deutschland.

Adenocarcinoma of the esophagus is the oncologic entity with the most progressive incidence in western countries over the last 30 years. This is caused by, among other factors, a growing rate of obesity and the associated gastroesophageal reflux disease. Typical sites of metastasis include the liver, lymph nodes and peritoneum. Read More

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http://dx.doi.org/10.1007/s00108-020-00802-3DOI Listing

How high is too high? Extensive mediastinal dissection in patients with hiatal hernia repair.

Surg Endosc 2020 May 19. Epub 2020 May 19.

Center for Advanced Surgical Technology, 986246 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE, 68198-6246, USA.

Background: Approximately 10% of patients receiving anti-reflux procedures present with shortened esophagus. Collis gastroplasty (CG) is the current gold standard for esophageal lengthening, but mediastinal esophageal mobilization without gastroplasty may be an alternative approach. This study assesses preoperative and intraoperative hernia characteristics and mediastinal dissection impact in patients with large hiatal hernia repair (HHR). Read More

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http://dx.doi.org/10.1007/s00464-020-07647-9DOI Listing

Chronic High-Fat Diet Induces Early Barrett's Esophagus in Mice through Lipidome Remodeling.

Biomolecules 2020 May 16;10(5). Epub 2020 May 16.

QIMR Berghofer Medical Research Institute, Herston, Brisbane 4006, QLD, Australia.

Esophageal adenocarcinoma (EAC) incidence has been rapidly increasing, potentially associated with the prevalence of the risk factors gastroesophageal reflux disease (GERD), obesity, high-fat diet (HFD), and the precursor condition Barrett's esophagus (BE). EAC development occurs over several years, with stepwise changes of the squamous esophageal epithelium, through cardiac metaplasia, to BE, and then EAC. To establish the roles of GERD and HFD in initiating BE, we developed a dietary intervention model in C57/BL6 mice using experimental HFD and GERD (0. Read More

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http://dx.doi.org/10.3390/biom10050776DOI Listing

Combined partial posterior fundoplication with laparoscopic sleeve gastrectomy for morbid obese patients with symptomatic GERD. Video case report.

Int J Surg Case Rep 2020 May 8;71:34-36. Epub 2020 May 8.

Türkçapar Bariatrics, Obesity Center, İstanbul, Turkey.

İNTRODUCTION: Gastroesophageal reflux disease (GERD), which can be seen in up to 30% in postoperative series, is perhaps the most important complication of sleeve gastrectomy(SG). The general trend for patients who are planning to have bariatric surgery and have symptomatic GERD, Roux-en-Y gastric bypass is the most common choice. CASE PRESENTATION AND MANAGEMENT: A 42-year-old female patient with a body mass index of 36 kg/m presented to our clinic with obesity and symptomatic GERD. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235945PMC

Diagnosis of gastroesophageal reflux: an update on current and emerging modalities.

Ann N Y Acad Sci 2020 May 19. Epub 2020 May 19.

Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri.

Gastroesophageal reflux disease (GERD) is a common condition characterized by troublesome symptoms or esophageal mucosal lesions attributed to excessive esophageal acid exposure. Various pathophysiological mechanisms account for GERD, including impaired esophageal peristalsis and anatomical or physiological defects at the esophagogastric junction (EGJ). Endoscopy identifies GERD complications and detects potential alternative diagnoses. Read More

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http://dx.doi.org/10.1111/nyas.14369DOI Listing

Does weight gain, throughout 15 years follow-up after Nissen laparoscopic fundoplication, compromise reflux symptoms control?

Arq Bras Cir Dig 2020 18;33(1):e1488. Epub 2020 May 18.

School of Medicine, São Paulo University, São Paulo, SP, Brazil.

Background: Gastroesophageal reflux disease is defined by the abnormal presence of gastric content in the esophagus, with 10% incidence in the Western population, being fundoplication one treatment option.

Aim: To evaluate the early (six months) and late (15 years) effectiveness of laparoscopic fundoplication, the long term postoperative weight changes, as well as the impact of weight gain in symptoms control.

Methods: Prospective study of 40 subjects who underwent laparoscopic Nissen's fundoplication. Read More

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http://dx.doi.org/10.1590/0102-672020190001e1488DOI Listing

Comparing effectiveness of high-dose Atorvastatin and Rosuvastatin among patients undergone Percutaneous Coronary Interventions: A non-concurrent cohort study in India.

PLoS One 2020 19;15(5):e0233230. Epub 2020 May 19.

Mission Arogya Health and Information Technology Research Foundation, Kolkata, West Bengal, India.

Introduction: Atorvastatin-80mg/day and Rosuvastatin-40mg/day are the commonest high-dose statin (3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors) regimes for post-PCI (Percutaneous Coronary Interventions) patients to lower (by ≥50%) blood low-density-lipoprotein cholesterol (LDL-C). Dearth of conclusive evidence from developing world, regarding overall safety, tolerability and comparative effectiveness (outcome/safety/tolerability/endothelial inflammation control) of Rosuvastatin over Atorvastatin in high-dose, given its higher cost, called for an overall and comparative assessment among post-PCI patients in a tertiary cardiac-care hospital of Kolkata, India.

Methods: A record-based non-concurrent cohort study was conducted involving 942 post-PCI patients, aged 18-75 years, on high-dose statin for three months and followed up for ≥one year. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233230PLOS

Effectiveness of Laparoscopic Sleeve Gastrectomy in Super-obese and Non-Super-obese Patients.

Surg Laparosc Endosc Percutan Tech 2020 May 15. Epub 2020 May 15.

Endocrine, Metabolic, and Bariatric Unit, Center of Excellence for the EAC-BC.

Objectives: The primary aim of this study was to assess the effectiveness of sleeve gastrectomy (SG) in super-obese patients. The secondary aim was to identify patient characteristics associated with worse SG outcomes in this group.

Methods: A retrospective analysis was carried out of our electronic prospective bariatric surgery patient database, including all patients who underwent SG between January 2007 and January 2017. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000801DOI Listing

Gastroesophageal Reflux Disease, Obesity, and Roux-en-Y Gastric Bypass: Complex Relationship-a Narrative Review.

Authors:
Michel Suter

Obes Surg 2020 May 18. Epub 2020 May 18.

Department of Surgery, Riviera-Chablais Hospital, Rte des Tilles 6A, 1847, Rennaz, Switzerland.

Common, gastroesophageal reflux disease (GERD) is promoted by increased abdomino-thoracic pressure gradient and affects a large proportion of patients with obesity. Weight loss is one of the mainstays of conservative treatment. While fundoplication is recognized as the best surgical option in the general population, its results in severely obese individuals are controversial. Read More

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http://dx.doi.org/10.1007/s11695-020-04690-2DOI Listing

Apnea in preterm neonates: what's the role of gastroesophageal reflux? A systematic review.

Dig Liver Dis 2020 May 15. Epub 2020 May 15.

Pediatric Department, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.

A causal relationship between gastro-esophageal reflux (GER) and apnea in preterm infants has been frequently hypothesized and is currently debated. The present study aims at reviewing the currently available scientific evidence, in order to clarify the role of GER on the occurrence of apnea and to help improving the clinical management of apneic preterm neonates. We performed a systematic literature search to identify all the clinical studies on preterm neonates that properly assessed the relationship between apnea and GER. Read More

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http://dx.doi.org/10.1016/j.dld.2020.03.032DOI Listing

Modified laparoscopic sleeve gastrectomy with Rossetti antireflux fundoplication: results after 220 procedures with 24-month follow-up.

Surg Obes Relat Dis 2020 Apr 4. Epub 2020 Apr 4.

General and Oncologic Surgery Department, Centre of Bariatric Surgery, San Marco Hospital GSD, Zingonia, Italy.

Background: Gastroesophageal reflux disease (GERD), including erosive esophagitis, is highly prevalent in the obese population. Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric procedures. The relationship between LSG and GERD has gained increasing attention. Read More

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http://dx.doi.org/10.1016/j.soard.2020.03.029DOI Listing

Two-Year Outcome after Laparoscopic Fundoplication in Pediatric Patients with Gastroesophageal Reflux Disease.

J Laparoendosc Adv Surg Tech A 2020 May 19. Epub 2020 May 19.

Department of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Many studies on short-term efficacy of laparoscopic antireflux surgery (LARS) have shown good to excellent results on reflux symptom control and health-related quality of life (HRQoL). Prospective studies on the long-term efficacy, however, are scarce and indicate that the efficacy of symptom control may decline over time. The aim of this study is to assess the 2-year outcome on reflux symptoms and HRQoL after LARS. Read More

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http://dx.doi.org/10.1089/lap.2020.0014DOI Listing

Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux disease with anti-reflux mucosectomy: Experience of 109 cases.

Dig Endosc 2020 May 16. Epub 2020 May 16.

Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.

Objectives: Some patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) therapy. Anti-reflux mucosectomy (ARMS) is a minimally invasive endoscopic procedure for treatment of GERD. In this study, we retrospectively evaluated the outcomes of ARMS performed in patients with PPI-refractory GERD at our institution. Read More

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http://dx.doi.org/10.1111/den.13727DOI Listing

The characteristics of antireflux surgery compared to proton pump inhibitor treatment in Korea: a nationwide study using claim data from 2007 to 2016.

Ann Surg Treat Res 2020 May 28;98(5):254-261. Epub 2020 Apr 28.

Department of Surgery, Kosin University College of Medicine, Busan, Korea.

Purpose: Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PPI) treatments.

Methods: We used Korean patients who underwent fundoplication (n = 342, surgery group) and a 25% random sample of all patients diagnosed with gastroesophageal reflux disease (GERD) who were prescribed PPIs for more than 12 weeks (n = 130,987, medication group) between 2007 to 2016. Read More

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http://dx.doi.org/10.4174/astr.2020.98.5.254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200601PMC

Impact of ineffective esophageal motility on chemical clearance in patients with gastroesophageal reflux symptoms.

Dis Esophagus 2020 May 15. Epub 2020 May 15.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Ineffective esophageal motility (IEM) is the most common manometric abnormality in gastroesophageal reflux disease (GERD). However, the impact of IEM on esophageal chemical clearance has not been fully investigated. This study aimed to determine the impact of IEM on esophageal chemical clearance in patients with GERD. Read More

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http://dx.doi.org/10.1093/dote/doaa026DOI Listing

Postfundoplication retching: Strategies for management.

J Pediatr Surg 2020 Apr 14. Epub 2020 Apr 14.

Department of Paediatric Surgery, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK. Electronic address:

Background: Retching is a common symptom in children following antireflux surgery, particularly in those with neurodisability. There is now a strong body of evidence that implicates retching as a major cause of wrap breakdown. Retching is not a symptom of gastroesophageal reflux disease; it is a component of the emetic reflex. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.03.032DOI Listing

Jackhammer esophagus: A meta-analysis of patient demographics, disease presentation, high-resolution manometry data, and treatment outcomes.

Neurogastroenterol Motil 2020 May 14:e13870. Epub 2020 May 14.

Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada.

Background: Jackhammer esophagus (JE) is a newly described esophageal motility disorder. However, there are limited data on JE and this entity remains misunderstood.

Methods: We performed a systematic review of clinical series on JE through MEDLINE, EMBASE, and Web of Science. Read More

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http://dx.doi.org/10.1111/nmo.13870DOI Listing

Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis.

Cardiovasc Ther 2020 22;2020:2683740. Epub 2020 Apr 22.

Department of Cardiology, Affiliated ZhongDa Hospital of Southeast University (HZ), Nanjing 210009, China.

Background: We performed a network meta-analysis (NMA) comparing the efficacy (stroke or systemic embolism) and safety (major bleeding) among different non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) and renal impairment, with the aim of recommending the proper drug and the dose based on renal function.

Methods: We searched PubMed, EMBASE, Web of Science, and Cochrane Library with the items "dabigatran, edoxaban, apixaban, rivaroxaban, warfarin, and atrial fibrillation" through August 2019. NMA was analyzed with R (version 3. Read More

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http://dx.doi.org/10.1155/2020/2683740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197012PMC

Factors associated with wheezing among Lebanese children: Results of a cross-sectional study.

Allergol Immunopathol (Madr) 2020 May 10. Epub 2020 May 10.

INSPECT-LB: Institut National de Santé Publique, Epidémiologie Clinique et Toxicologie - Liban, Beirut, Lebanon; Faculty of Pharmacy, Lebanese University, Beirut, Lebanon; Faculty of Medicine, Lebanese University, Beirut, Lebanon.

Background: In Lebanon, asthma is underdiagnosed due to low access to healthcare, particularly in rural areas, although asthma diagnosis in children is based mainly on clinical symptoms. Thus, wheezing might be more suggestive of undiagnosed respiratory diseases including asthma in Lebanese children. This study aimed to determine the factors associated with wheezing in Lebanese children without asthma diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.003DOI Listing

Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.

J Am Geriatr Soc 2020 May 13. Epub 2020 May 13.

School of Medicine, IMPACT the Institute for Mental and Physical Health and Clinical Translation, Barwon Health, Deakin University, Geelong, Victoria, Australia.

Objectives: To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population.

Design: Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.

Setting: Multicentric study conducted in Australia and the United States. Read More

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http://dx.doi.org/10.1111/jgs.16468DOI Listing

Comparison of the efficiency of two different proton pump inhibitor formula in treatment of patients with atypical gastroesophageal reflux disease: a prospective randomized study.

J Gastroenterol Hepatol 2020 May 13. Epub 2020 May 13.

Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Background And Aim: The prospective, open-label, randomized study aims to compare the efficacy of lansoprazole, a fast orally disintegrating proton pump inhibitor (PPI), and dexlansoprazole, a dual delayed release PPI, in patients with atypical symptoms of gastroesophageal reflux disease (GERD).

Methods: Patients with atypical GERD symptoms with a total reflux symptom index score > 10 were eligible for enrollment. From February 2018 to December 2019, 232 subjects were randomly assigned (1:1 ratio) to receive oral lansoprazole, Takepron OD 30 mg, once daily before breakfast or oral dexlansoprazole, Dexilant 60 mg, once daily before breakfast for 8 weeks. Read More

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http://dx.doi.org/10.1111/jgh.15093DOI Listing

Trends and Outcomes of Gastrointestinal Bleeding Among Septic Shock Patients of the United States: A 10-Year Analysis of a Nationwide Inpatient Sample.

Cureus 2020 May 8;12(5):e8029. Epub 2020 May 8.

Pulmonary and Critical Care Medicine, Robert Packer Hospital, Sayre, USA.

Introduction Gastrointestinal bleeding (GIB) complicating septic shock (SS) presents a therapeutic challenge in intensive care units. Large-scale data regarding utilization, length of stay, and cost outcomes of this association are lacking. Methods We queried the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample from 2003 to 2012, and identified all adult patients aged ≥18 years hospitalized for SS by the International Classification of Diseases, Ninth Revision (ICD-9) diagnostic code for SS and GIB. Read More

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http://dx.doi.org/10.7759/cureus.8029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212718PMC

Magnetic sphincter augmentation versus fundoplication for gastroesophageal reflux disease: pros and cons.

Curr Opin Gastroenterol 2020 May 7. Epub 2020 May 7.

The Division of Upper GI and General Surgery at the University of Southern California, Los Angeles, California, USA.

Purpose Of Review: The purpose of this magnetic sphincter augmentation (MSA) year in review article is to provide a clear understanding for the current state of MSA literature in 2019, and contrast MSA outcomes with traditional fundoplication.

Recent Findings: Continued work was performed in 2019 to expand patient populations eligible for MSA including those with hiatal hernia, post-bariatric patients, patients necessitating a thoracic approach, and patients with esophageal intestinal metaplasia. Additionally, a large systematic review reinforced earlier findings comparing laparoscopic fundoplication to MSA. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000643DOI Listing

EsoFLIP for esophageal dilation: proposed advantages.

Curr Opin Gastroenterol 2020 May 7. Epub 2020 May 7.

Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Purpose Of Review: The EsoFLIP integrates impedance planimetry technology into a dilator balloon capable of dilating from diameters between 10 and 30 mm via controlled volumetric distension while providing real-time visualization and objective measurement during the dilation procedure, potentially negating the need for fluoroscopy. This review aims to describe the use and application of EsoFLIP and the potential advantages this novel technology may afford.

Recent Findings: Small pilot and retrospective studies demonstrate EsoFLIP feasibility and safety, but larger studies are needed to understand its impact on clinical outcomes. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000639DOI Listing

The Effect of Helicobacter pylori Eradication in Patients with Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Studies.

Dig Dis 2020 May 12:1-8. Epub 2020 May 12.

Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China,

Aim: Helicobacter pylori infection has been established as a definite risk factor for gastric cancer. However, the consequence of H. pylori eradication on the progression of gastroesophageal reflux disease (GERD) remains controversial. Read More

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http://dx.doi.org/10.1159/000504086DOI Listing

Swallowing Difficulty in Diffuse Idiopathic Skeletal Hyperostosis with Metabolic Syndrome.

Korean J Neurotrauma 2020 Apr 1;16(1):90-98. Epub 2020 Apr 1.

Department of Neurosurgery, School of Medicine, Inje University Busan Paik Hospital, Busan, Korea.

Diffuse idiopathic skeletal hyperostosis (DISH) is a disease of unknown etiology developing following ossification of the antero-lateral ligaments of the spine. Mostly, prevailing elderly adult males, it is an uncommon cause of dysphagia and dysphonia. We report three cases of DISH with metabolic syndrome. Read More

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http://dx.doi.org/10.13004/kjnt.2020.16.e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192806PMC

[Clinical observation on gastroesophageal reflux asthma treated with needling technique].

Zhongguo Zhen Jiu 2020 May;40(5):488-92

School of Acupuncture- Moxibustion and Tuina, Beijing University of CM, Beijing 100029, China.

Objective: To compare the clinical effect on gastroesophageal reflux asthma between the needling technique of acupuncture (acupuncture for promoting the circulation of the governor vessel and reducing the reversed ) and omeprazole enteric capsules (OME).

Methods: A total of 60 patients with gastroesophageal reflux asthma were randomized into an acupuncture group and a western medication group, 30 cases in each one. The basic treatment for anti-bronchial asthma was provided in both of the groups. Read More

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http://dx.doi.org/10.13703/j.0255-2930.20191112-k0001DOI Listing

Young children with Noonan syndrome: evaluation of feeding problems.

Eur J Pediatr 2020 May 11. Epub 2020 May 11.

Radboud Institute for Health Sciences, Amalia Children's Hospital, Department of Pediatrics, Radboud University Medical Center, Nijmegen, The Netherlands.

Noonan syndrome (NS) is a common genetic syndrome with a high variety in phenotype. Even though genetic testing is possible, NS is still a clinical diagnosis. Feeding problems are often present in infancy. Read More

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http://dx.doi.org/10.1007/s00431-020-03664-xDOI Listing

[Pepsin and bile acids detection in saliva for the diagnosis of gastroesophageal reflux disease].

Zhonghua Yi Xue Za Zhi 2020 May;100(18):1414-1418

Department of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China.

To identify the value of the detection of pepsin and bile acids in saliva for the diagnosis of gastroesophageal reflux disease(GERD). From January 2018 to June 2019, 104 GERD patients and 43 healthy people in Guangdong Provincial People's Hospital were recruited. The 104 patients of GERD group were divided into four sub-groups, including esophageal symptoms GERD group, extraesophageal symptoms GERD group, anxiety or depression group, non-anxiety and non-depression group. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191111-02454DOI Listing