Search Our Scientific Publications & Authors

J Med Cases 2021 Apr 8;12(4):152-156. Epub 2021 Feb 8.

Department of Anesthesiology and Critical Care, Saint Louis University Hospital, 1201 S. Grand Boulevard, St. Louis, MO 63104, USA.

Propionic acidemia (PA) is a rare, multi-systemic inborn error of metabolism. PA results from an impaired activity of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC). PCC holds an essential role in the catabolic pathways for odd-chain fatty acids, cholesterol side-chains and branched-chain amino acids. Read More

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):61-64

International Federation ORL Societies (IFOS) Executive Board members Rome Italy.

Laryngopharyngeal reflux (LPR) is a common disease caused by the leaking beck of gastric material out of the esophagus. The main symptoms are dysphonia, dysphagia, and cough. There is an established use of proton pump inhibitors (PPI) in patients with suspected LPR in common practice. Read More

Tuberc Respir Dis (Seoul) 2021 May 13. Epub 2021 May 13.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Cough is the most common respiratory symptom that can result from various causes, and is a major clinical problem that reduces patients' quality of life. Thus, clinical guidelines for the treatment of cough were established in 2014 by the cough guideline committee under the Korean Academy of Tuberculosis and Respiratory Diseases. From October 2018 to July 2020, the cough guidelines were revised by the members of the committee based on the first guidelines. Read More

Endoscopy 2021 May 12. Epub 2021 May 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Cureus 2021 Apr 8;13(4):e14370. Epub 2021 Apr 8.

Critical Care, State University of New York Upstate Medical University, Syracuse, USA.

Idiopathic capillary leak syndrome (ICLS) occurs as a result of vascular membrane instability, which results in the leakage of several proteins from the vascular compartment to the interstitial spaces. It is an extremely rare disorder, with around 260 cases documented thus far. We present a case of a 35-year-old male with a past medical history of asthma and gastroesophageal reflux disease who initially presented to our hospital for the treatment of chronic demyelinating inflammatory neuropathy requiring plasmapheresis and steroid therapy. Read More

J Korean Med Sci 2021 May 10;36(18):e116. Epub 2021 May 10.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: In the past, general surgeons (GSs) without a pediatric surgical subspecialty often performed surgery on children and, even now, GSs are performing many pediatric surgeries. We aimed to investigate the involvement of pediatric surgeons (PSs) and GSs in pediatric surgery, compare the outcomes of surgery in the neonatal intensive care unit (NICU), and estimate the appropriate PS workforce in Korea.

Methods: We used surgical data from the National Health Insurance Service database that was collected from patients under the age of 19 years in hospitals nationwide from January 2002 to December 2017. Read More

J Clin Gastroenterol 2021 May 11. Epub 2021 May 11.

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Department of Gastroenterology and Hepatology, Pinghu Hospital, Health Science Center, Shenzhen University, Shenzhen, People's Republic of China.

Background: Lyon Consensus altered the previous understanding of endoscopic gastroesophageal reflux disease (GERD) and pointed out that only high-grade reflux esophagitis (RE) [Los Angeles (LA) grades C or D], Barrett's esophagus or peptic stricturing were considered confirmatory evidence for GERD but low-grade RE (LA grades A or B) was regarded as suspected GERD. We aimed to summarize the possible relationship between gastroesophageal flap valve (GEFV) and endoscopic GERD according to Lyon Consensus using meta-analysis of studies done in Asia.

Materials And Methods: Comprehensive searches of PubMed, WOS, Embase, SinoMed, and CNKI databases were completed to identify eligible studies published before September 22, 2019. Read More

Clin Infect Dis 2021 May 11. Epub 2021 May 11.

Center of Innovation for Complex Chronic Healthcare (CINCCH), Hines Jr. Veterans Affairs Hospital, Hines, IL,USA.

Introduction: Carbapenem-resistant Enterobacterales (CRE) cause approximately 13,100 infections with 8% mortality in the United States annually. The subset of carbapenemase-producing CRE (CP-CRE) infections have much higher mortality rates (40% -50%). There has been little research on characteristics unique to CP-CRE. Read More

World J Clin Pediatr 2021 May 9;10(3):15-28. Epub 2021 May 9.

Department of Pediatrics, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama P.O. Box 26671, Bahrain, Bahrain.

Medical comorbidities are more common in children with autism spectrum disorders (ASD) than in the general population. Some genetic disorders are more common in children with ASD such as Fragile X syndrome, Down syndrome, Duchenne muscular dystrophy, neurofibromatosis type I, and tuberous sclerosis complex. Children with autism are also more prone to a variety of neurological disorders, including epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headaches, and congenital abnormalities of the nervous system. Read More

Am J Med Genet A 2021 May 10. Epub 2021 May 10.

Health Outcomes, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA.

The goal of this study was to investigate the medical, communication, activities of daily living (ADLs), and mental health concerns affecting adolescents and adults with SATB2-associated syndrome (SAS). A comprehensive questionnaire was administered to the caregivers of 49 individuals 12 years or older with SAS (mean age was 19.4 years, range 12-37 years). Read More

Int Arch Otorhinolaryngol 2021 Apr 30;25(2):e273-e278. Epub 2020 Jun 30.

Department of Biochemistry, Pondicherry Institute of Medical Sciences, Kalapet, Puducherry, India.

 Twenty-four-hour multichannel intraluminal impedance with double probe pH monitoring (MII-pH), though considered the most sensitive tool for the diagnosis of gastroesophageal reflux disease (GERD), is invasive, time consuming, not widely available, and unable to detect non-acid reflux. In contrast, the presence of pepsin in the saliva would act as a marker for reflux, considering that pepsin is only produced in the stomach.  To evaluate the predictive value of salivary pepsin in diagnosing laryngopharyngeal reflux (LPR) as suggested by the results of reflux symptom index (RSI > 13), reflux finding score (RFS > 7), and positive response to treatment with a 4-week course of proton-pump inhibitors. Read More

World J Gastroenterol 2021 Apr;27(16):1751-1769

Department of Gastroenterology, Albany Medical Center, Schenectady, NY 12309, United States.

Gastroesophageal reflux disease (GERD) is one of the most commonly encountered digestive diseases in the world, with the prevalence continuing to increase. Many patients are successfully treated with lifestyle modifications and proton pump inhibitor therapy, but a subset of patients require more aggressive intervention for control of their symptoms. Surgical treatment with fundoplication is a viable option for patients with GERD, as it attempts to improve the integrity of the lower esophageal sphincter (LES). Read More

Surg Obes Relat Dis 2021 Mar 8. Epub 2021 Mar 8.

Section of Minimally Invasive and Bariatric Surgery, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, California; Center for Obesity and Metabolic Health, University of California, Los Angeles, California; Center for Advanced Surgical & Interventional Technology, University of California, Los Angeles, California. Electronic address:

Background: Small bowel obstruction (SBO) following laparoscopic Roux-en-Y gastric bypass (LRYGB) is associated with significant morbidity.

Objectives: To evaluate the rate of and risk factors for readmission for SBO within 30 days of LRYGB.

Setting: Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP)-accredited centers. Read More

Georgian Med News 2021 Mar(312):67-71

State Higher Educational Institution «Uzhhorod National University», Medical Faculty, Ukraine.

Of particular interest is the study of the peculiarities of clinical findings and diagnostics of gastroesophageal reflux disease (GERD) in patients with diabetes mellitus (DM). The aim of the research - to study the dynamics of cholecystokinin (CCK) level on the background of complex therapy using the ursodeoxycholic acid (UDCA) drug in patients with GERD with type 2 DM. 68 patients with combination of type 2 DM and GERD were examined. Read More

Georgian Med News 2021 Mar(312):23-26

2Ivane Javakhishvili Tbilisi State University, Georgia.

The purpose was to study the features and results of redo laparoscopic antireflux surgery. For the period from 2008 to 2019, in Odessa Regional Hospital laparoscopic antireflux operations were performed in 1164 patients. 57 patients underwent laparoscopic reoperation during the study period based on the following indications: recurrence of hiatal hernia (n=37), recurrent reflux (n=4), dysphagia (n=8), severe pain (n=5), esophageal stricture (n=3). Read More

Respir Med 2021 Apr 30;183:106439. Epub 2021 Apr 30.

Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, No. 389 Xincun Road, Shanghai, 200065, China. Electronic address:

Background: Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC). The purpose of the study is to identify its therapeutic predictors in a prospective clinical study.

Methods: 138 patients with suspected refractory GERC were treated with baclofen. Read More

Hum Genome Var 2021 May 6;8(1):16. Epub 2021 May 6.

Institute of Medical Genetics, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.

A recurrent ZSWIM6 variant, NM_020928.2:c.2737C>T [p. Read More

Am J Gastroenterol 2020 Dec;115(12):1939

Article Title: The Role of Symptom Association Analysis in Gastroesophageal Reflux Testing. Read More

Dig Dis Sci 2021 May 6. Epub 2021 May 6.

Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1023, New Zealand.

Background: Functional nausea and vomiting syndromes and gastroparesis, collectively grouped as nausea and vomiting syndromes (NVS), are overlapping conditions with incompletely understood pathophysiology. Gastric slow wave abnormalities are thought to contribute.

Aims: This study aimed to systematically review and meta-analyze the prevalence of slow wave abnormalities measured by electrogastrography (EGG) in patients with NVS. Read More

Am J Gastroenterol 2021 Apr 22. Epub 2021 Apr 22.

1Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA; 2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA; 3Division of Gastroenterology, Billings Clinic, Billings, Montana, USA.

Introduction: We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).

Methods: Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured. Read More

Otolaryngol Pol 2021 Feb;75(3):1-5

Department of Clinical Phonoaudiology and Speech Therapy, Medical University of Bialystok, Poland.

Introduction Gastroesophageal reflux disease (GERD) may cause extra-esophageal complications, including laryngopharyngeal reflux disease (LPR). It is caused by morphological changes in the laryngeal mucosa due to the regurgitation of gastric contents. Laryngopharyngeal reflux has a wide symptomatology. Read More

Pol Przegl Chir 2021 Mar;93(3):1-5

Jagiellonian University Medical College, Department of Pediatric Surgery, University Children's Hospital, Kraków, Poland.

Introduction Despite proper surgical management in neonatal period, congenital oesophageal atresia [OA] may present serious source of lifelong disorders. The objective of our study is to present the most important facts about oesophageal atresia, types of treatment and possible complications which might demand surgical management in adult life. We would like to familiarize general surgeons with this matter to provide OA patients with proper medical care. Read More

Otolaryngol Pol 2021 Apr;75(2):42-50

Klinika Chirurgii Ogólnej, Onkologicznej i Przewodu Pokarmowego CMKP, Szpital im. Prof. W. Orłowskiego, Warszawa.

Gastrooesophageal reflux disease is the regurgitation of stomach contents into the esophagus, which causes troublesome symptoms or complications for the patient. Before starting the treatment, it is always necessary to objectively confirm gastroesophageal reflux disease, especially in correlation with ENT symptoms, as extra esophageal complications. In diagnostics, the "gold standard" is a 24-hour impedance-pH supplemented with endoscopy. Read More

Am J Physiol Gastrointest Liver Physiol 2021 May 5. Epub 2021 May 5.

Department of General Internal Medicine 2, Kawasaki Medical School, Japangrid.415086.e.

A device that can easily measure electrical impedance might be a helpful tool for investigating the pathophysiology of gastroesophageal reflux disease. The first aim of this study was to validate our newly developed bioelectrical admittance measurement (BAM) through in vitro experimentation. The second aim was to investigate whether evaluation of BAM by this measurement differed between patients with heartburn according to their response to proton pump inhibitor (PPI) therapy. Read More

J Gastrointest Surg 2021 May 4. Epub 2021 May 4.

Department of Surgery, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil.

Therap Adv Gastroenterol 2021 16;14:17562848211004827. Epub 2021 Apr 16.

Allegheny Health Network Ringgold Standard Institution - Surgery, Pittsburgh, PA, USA.

Goals: To assess the long-term results of transoral incisionless fundoplication (TIF 2).

Background: TIF with the EsophyX2 is an accepted procedure to treat gastroesophageal reflux disease (GERD). Long-term data have been limited. Read More

Toxicol Pathol 2021 May 4:1926233211004873. Epub 2021 May 4.

Nonclinical Study Management, Eli Lilly and Company, Indianapolis, IN, USA.

The tolerability of single daily gavage doses of 0.5% or 2.0% (wt/vol) sodium lauryl sulfate (SLS) in 11- to 12-week-old male CD-1 mice was evaluated in a study of 3 months in duration. Read More

Mov Disord 2021 May 3. Epub 2021 May 3.

Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA.

Background: Prodromal Parkinson's disease of skin, genitourinary, and gastrointestinal systems offers a unique window for understanding early disease pathogenesis and developing disease modifying treatments. However, prior studies are limited by incomplete timing information, small sample size, and lack of adjustment for known confounders. Verifying prodromal timing and identifying new disorders in these accessible organs is critically important given their broad use. Read More

BMC Gastroenterol 2021 May 3;21(1):201. Epub 2021 May 3.

Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15. Col. Sección XVI, CP 14000, México City, D.F., Mexico.

Background: The clinical endoscopic phenotypes of gastroesophageal reflux disease (GERD) are classified as Barrett's esophagus (BE), erosive esophagitis (EE) and non-erosive gastroesophageal reflux disease (NERD). NERD is subclassified as abnormal acid exposure (AAE) and normal acid exposure (NAE) based on pH monitoring study results. The aim of this study was to characterize genes involved in the pathophysiology and immune response of GERD. Read More

Dig Dis Sci 2021 May 3. Epub 2021 May 3.

Division of Gastroenterology, Hunter Holmes McGuire Richmond VA Medical Center, Gastroenterology # 111N, Richmond, VA, 23249, USA.

Introduction: Epithelial barrier function (EBF) disruption is a key mechanism underlying gastroesophageal reflux disease (GERD). Our aim was to assess whether two novel technologies, probe-based confocal laser endomicroscopy (pCLE) and mucosal integrity testing (MIT), could assess EBF.

Methods: We prospectively enrolled patients undergoing upper endoscopy for refractory GERD or non-GERD conditions. Read More