34,460 results match your criteria Gastroesophageal Reflux Disease


Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Institute of Gastroenterology, Nutrition, and Liver Disease, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Objectives: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children.

Methods: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Read More

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December 2018

THE EFFICACY OF THE DIFFERENT ENDOSCOPIC TREATMENTS VERSUS SHAM, PHARMACOLOGIC OR SURGICAL METHODS FOR CHRONIC GASTROESOPHAGEAL REFLUX DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):296-305

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Endoscopia Avançada Gastrointestinal, São Paulo, SP, Brasil.

Background: Endoscopic antireflux treatments for gastroesophageal reflux disease (GERD) are still evolving, and most of the published studies address symptom relief in the short-term. Objective - We aimed to perform a systematic review and meta-analysis focused on evaluating the efficacy of the different endoscopic procedures.

Methods: Search was restricted to randomized controlled trials (RCTs) on MedLine, Cochrane, SciELO, and EMBASE for patients with chronic GERD (>6 months), over 18 years old and available follow up of at least 3 months. Read More

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Association Between Erosive Esophagitis and the Anthropometric Index in the General Korean Population

Authors:
Hyun Young Kim

Balkan Med J 2018 12 12. Epub 2018 Dec 12.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea

Background: An association between obesity and gastroesophageal reflux disease (GERD) has been reported. However, previous studies have focused on obesity or central obesity.

Aims: The aim of this study was to investigate the association of anthropometric index and endoscopic erosive esophagitis (EE) in health check-up of Koreans. Read More

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December 2018

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018

Corrigendum to: Can ARFI of the liver and spleen predict the presence of gastroesophageal varies? [Clin Radiol 73 (12) (2018) 1046-1051].

Clin Radiol 2018 Dec 8. Epub 2018 Dec 8.

Royal Liverpool and Broadgreen University Hospitals NHS Trust, Prescot Street, Liverpool, L7 8XP, UK.

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December 2018

Concomitant Hiatal Hernia Repair Is more Common in Laparoscopic Sleeve Gastrectomy than During Laparoscopic Roux-en-Y Gastric Bypass: an Analysis of 130,772 Cases.

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

Division of Foregut, Bariatric and Advanced GI Surgery, Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY, 11794, USA.

Obesity is associated with the development of gastroesophageal reflux disease (GERD) and hiatal hernia (HH). This study aimed to assess practice patterns regarding concomitant HH repair (HHR) during laparoscopic sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). The incidence of concomitant HHR with LSG or LRYGB was analyzed using the 2015 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database. Read More

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December 2018
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Overall and Estrogen Receptor-Positive Breast Cancer Incidences Are Decreased Following Bariatric Surgery.

Obes Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.

Introduction: Bariatric surgery treats morbid obesity resulting in long-lasting weight loss. Elevated body mass index (BMI) increases breast cancer risk. We hypothesized that patients undergoing bariatric surgery would have decreased overall and estrogen receptor (ER)-positive breast cancer incidences compared to a propensity-matched non-surgical cohort. Read More

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December 2018

Safety and efficacy of trastuzumab administered as a 30-min infusion in patients with HER2-positive advanced gastric cancer.

Cancer Chemother Pharmacol 2018 Dec 8. Epub 2018 Dec 8.

CELLTRION Healthcare Co. Ltd, Incheon, Republic of Korea.

Purpose: To investigate the safety and efficacy of 30-min maintenance infusions of trastuzumab in advanced gastric cancer positive for human epidermal growth factor receptor 2 (HER2).

Methods: This was a retrospective study conducted across five Korean hospitals in patients with HER2-positive gastric or gastroesophageal junction adenocarcinoma treated with first-line, 3-weekly trastuzumab plus chemotherapy. The first dose of trastuzumab (8 mg/kg) was administered as a 90-min infusion, with all subsequent maintenance infusions (6 mg/kg) given over 30 min. Read More

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December 2018

LONG-NONCODING RNAs in gastroesophageal cancers.

Noncoding RNA Res 2018 Dec 1;3(4):195-212. Epub 2018 Nov 1.

Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, PD, Italy.

Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying 'targetable' molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. Read More

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December 2018

Intractable apnoeic seizures in a child with a deletion typically associated with Williams syndrome.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Division of Pediatric Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto.

Williams-Beuren syndrome is rarely associated with epilepsy. One previously reported case showed an association with apnoeic seizures while a few other cases showed an association with infantile epileptic spasms and generalized and focal seizures. We report the case of a 13-month-old boy with a deletion typically associated with Williams-Beuren syndrome, who presented with isolated apnoeic seizures which were refractory to multiple antiepileptic drugs but partially responsive to the ketogenic diet. Read More

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December 2018

Factors Associated with Dysfunctional Breathing in patients with Difficult to Treat Asthma.

J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.

Allergy, Asthma & Clinical Immunology, The Alfred Hospital, 55 Commercial Road, Melbourne; Public Health & Preventive Medicine, Monash University.

Background: Understanding of dysfunctional breathing in difficult asthma patients who remain symptomatic despite maximal inhaler therapy is limited.

Objective: We characterised the pattern of dysfunctional breathing in patients with difficult asthma and identified possible contributory factors.

Methods: Dysfunctional breathing was identified in patients with difficult asthma using the Nijmegen questionnaire (score >23). Read More

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December 2018

Pharmacotherapy for metastatic esophageal cancer: where do we need to improve?

Expert Opin Pharmacother 2018 Dec 7:1-10. Epub 2018 Dec 7.

a Department of Medicine , Perlmutter Cancer Center, NYU Langone Medical Center , New York , NY , USA.

Introduction: Esophageal cancer is a heterogeneous cancer comprised of differing cells of origin, molecular changes, and immune microenvironments. To date, most advances have been made in chemotherapy regimens where a one-size-fits-all approach is used. As a result, there remains a lack of tailored treatment options for such a heterogeneous cancer. Read More

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December 2018

Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

Changes in the Distal Esophageal Microbiota in Chinese Patients with Reflux Esophagitis.

J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.

Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Changes in microbiota structure in the distal esophagus may be associated with the pathogenesis of gastroesophageal reflux disease. The composition of the distal esophageal microbiota between Chinese patients and healthy volunteers was compared through metagenomic high-throughput DNA sequencing and bioinformatic analyses.

Methods: Healthy volunteers (HV) and patients with reflux esophagitis (RE) were enrolled. Read More

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December 2018
6 Reads

Does the use of targeted agents in advanced gastroesophageal cancer increase complete response? A meta-analysis of 18 randomized controlled trials.

Cancer Manag Res 2018 12;10:5505-5514. Epub 2018 Nov 12.

Laboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, Hainan 571101, China,

Purpose: We aimed to investigate whether the use of targeted agents (TAs) in advanced gastroesophageal cancer (GEC) increased the complete response (CR) and to assess the surrogate endpoints for survival in the targeted treatment of GEC by using a meta-analysis of randomized controlled trials (RCTs).

Methods: Eligible studies were identified using Medline, PubMed, and meeting abstracts. Searches were last updated on April 30, 2018. Read More

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November 2018

Predictors of Survival in Patients with Advanced Gastrointestinal Malignancies Admitted to the Intensive Care Unit.

Oncologist 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Patients with cancer have a high use of health care utilization at the end of life, which can frequently involve admissions to the intensive care unit (ICU). We sought to evaluate the predictors for outcome in patients with gastrointestinal (GI) cancer admitted to the ICU for nonsurgical conditions.

Patients And Methods: The primary objective was to determine the predictors of hospital mortality. Read More

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December 2018

Promising efficacy of SHR-1210, a novel anti-programmed cell death 1 antibody, in patients with advanced gastric and gastroesophageal junction cancer in China.

Cancer 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The clinical response to anti-programmed cell death 1 (PD-1) antibodies in patients with advanced gastric and gastroesophageal junction (GEJ) cancer in China has not been reported.

Methods: This study evaluated the efficacy and safety of SHR-1210, an anti-PD-1 antibody, in patients with advanced gastric/GEJ cancer in a phase 1 trial. The associations between candidate biomarkers (programmed death ligand 1 [PD-L1] expression, mismatch repair status, tumor mutation load, and lactate dehydrogenase [LDH] levels) and the efficacy of SHR-1210 were also explored. Read More

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December 2018
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Lifestyle Modifications in Adults and Older Adults With Chronic Gastroesophageal Reflux Disease (GERD).

Crit Care Nurs Q 2019 Jan/Mar;42(1):64-74

NYU Langone Health, Tisch Hospital, New York (Mr Commisso) and NYU Rory Meyers College of Nursing, New York (Mr Lim).

Gastroesophageal reflux disease (GERD) is a chronic disorder that causes the unwanted backflow of gastric contents into the esophagus, throat, and mouth. Gastroesophageal reflux disease affects roughly 20% of the US population. It is estimated that older adults experience GERD symptoms more commonly and with greater severity because of age-related physiologic changes. Read More

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December 2018
2 Reads

Thailand Dyspepsia Guidelines: 2018.

J Neurogastroenterol Motil 2018 Nov 23. Epub 2018 Nov 23.

Department of Medicine, Faculty of Medicine, Chulalongkorn University and KingChulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand.

The management of dyspepsia in limited-resource areas has not been established. In 2017, key opinion leaders throughout Thailand gathered to review and evaluate the current clinical evidence regarding dyspepsia and to develop consensus statements, rationales, levels of evidence, and grades of recommendation for dyspepsia management in daily clinical practice based on the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. This guideline is mainly focused on the following four topics: (1) evaluation of patients with dyspepsia, (2) management, (3) special issues (overlapping gastroesophageal reflux disease/irritable bowel syndrome and non-steroidal anti-inflammatory drug/aspirin use), and (4) long-term follow-up and management to provide guidance for physicians in Thailand and other limited-resource areas managing such patients. Read More

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November 2018
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Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker.

J Neurogastroenterol Motil 2018 Nov 20. Epub 2018 Nov 20.

Fellowship Training Center and Medical Education Center, Keio University School of Medicine, Tokyo, Japan.

Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related conditions, such as gastroesophageal reflux disease, peptic ulcer disease, and infection, and for the prevention of low-dose aspirin or nonsteroidal anti-inflammatory drug associated peptic ulcers. Vonoprazan is a first-in-class potassium-competitive acid blocker, which has distinct advantages compared to other conventional proton pump inhibitors in terms of the rate and effectiveness at which gastric acid suppression occurs. Due to its strong gastric acid suppression capabilities, vonoprazan serves as an effective drug for the treatment of gastroesophageal reflux disease and infection. Read More

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November 2018
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ZW25 Active in HER2-positive Cancers.

Authors:

Cancer Discov 2018 Nov 30. Epub 2018 Nov 30.

A novel anti-HER2 therapy, ZW25, may be effective and well tolerated in patients with a variety of HER2-positive cancers. In a phase I trial, patients treated with the drug-most of whom had gastroesophageal or colorectal cancer-had an objective response rate of 41% and mild side effects. Read More

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November 2018

Considering the role of incidental appendectomy during colonic interposition gastroesophageal reconstruction.

J Thorac Cardiovasc Surg 2018 Oct 28. Epub 2018 Oct 28.

Division of Thoracic Surgery, Department of Surgery, MedStar Georgetown University Hospital, Washington, DC. Electronic address:

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October 2018

Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children.

Pediatr Neurol 2018 Oct 3;87:30-35. Epub 2018 Aug 3.

Departments of Neurology and Pediatrics, The Johns Hopkins Hospital, Baltimore, Baltimore, Maryland. Electronic address:

Background: Hormonal therapy is the treatment of choice in most patients with infantile spasms, but the optimal way to provide this therapy is unclear. Intramuscular adrenocorticotropic hormone (ACTH) has historically used first-line; however, there are significant logistical and financial issues. Our institution has used high-dose prednisolone as the first-line hormonal treatment of infantile spasms since 2006 and published our early experience with 15 infants in 2009. Read More

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October 2018
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SHORT-TERM RESULTS OF MINIMALLY INVASIVE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE BY RADIOFREQUENCY (STRETTA): FIRST BRAZILIAN SERIES OF CASES.

Arq Gastroenterol 2018 Nov;55Suppl 1(Suppl 1):52-55

Instituto Endovitta, São Paulo, SP, Brasil.

Background: New endoscopic treatments for gastroesophageal reflux (GERD) are developed every year and are indicated in cases that are refractory to conventional therapies as well as after surgical treatment failure.

Objective: To present the first cases of endoscopic therapy for GERD performed in Brazil.

Methods: Use of radiofrequency with the Stretta procedure in symptomatic volunteers diagnosed with GERD. Read More

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November 2018

Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma.

Am J Clin Oncol 2018 Dec 3. Epub 2018 Dec 3.

Mayo Clinic, Rochester, MN.

Background: Our purpose was to evaluate the prognostic impact of pathologically confirmed esophageal adenosquamous carcinoma (ASC) and its association with HER2 status and clinicopathologic characteristics.

Methods: Among 796 patients with esophageal or gastroesophageal junction adenocarcinoma who underwent curative resection, surgical pathology reports were reviewed, and suspected ASC was confirmed utilizing p63 and CK5/6 immunostaining. HER2 status was determined using immunohistochemistry and fluorescence in situ hybridization. Read More

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December 2018
1 Read

Intestinal metaplasia at the gastroesophageal junction is associated with gastroesophageal reflux but not with Helicobacter pylori infection.

Scand J Gastroenterol 2018 Dec 5:1-7. Epub 2018 Dec 5.

a Department of Gastroenterology, Skåne University Hospital , Clinical Sciences Lund, Lund University , Lund , Sweden.

Objective: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. Read More

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December 2018

Snare combined with endoclips in endoscopic submucosal dissection with mucosal traction for gastroesophageal neoplasia.

J Gastroenterol Hepatol 2018 Dec 4. Epub 2018 Dec 4.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.

Background And Aims: Mucosal traction as a "second hand" in endoscopic submucosal dissection (ESD) is very helpful for ESD operators. The efficacy of using a snare combined with endoclips to assist in ESD (SC-ESD) was evaluated whether it could achieve peroral external traction (PET) and internal traction (PIT) and real-time adjustment of mucosal traction position. This study aimed to preliminarily evaluate its feasibility. Read More

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December 2018
1 Read
3.504 Impact Factor

Phase 1 trial of avelumab (anti-PD-L1) in Japanese patients with advanced solid tumors, including dose expansion in patients with gastric or gastroesophageal junction cancer: the JAVELIN Solid Tumor JPN trial.

Gastric Cancer 2018 Dec 4. Epub 2018 Dec 4.

Merck Serono Co., Ltd, Tokyo, Japan.

Background: Avelumab is a human anti-PD-L1 IgG1 monoclonal antibody that has shown antitumor activity in several advanced cancers. We report results from JAVELIN Solid Tumor JPN, a phase 1 trial of avelumab in Japanese patients with advanced solid tumors with expansion in patients with advanced gastric cancer/gastroesophageal junction cancer.

Methods: In the dose-escalation part, eligible patients had various previously treated metastatic or advanced solid tumors. Read More

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December 2018
2 Reads

Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding.

World J Gastroenterol 2018 Nov;24(44):5025-5033

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.

Aim: To examine the association between the timing of endoscopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.

Methods: This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting (IPW) method. Read More

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November 2018
4 Reads

Nocturnal gastroesophageal reflux increases the risk of daytime sleepiness in women.

Sleep Med 2018 Oct 13;53:94-100. Epub 2018 Oct 13.

Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.

Objective: Daytime sleepiness is common in women and has negative health effects. Nocturnal gastroesophageal reflux (nGER) and snoring are risk factors for daytime sleepiness, but the effect of their interaction remains unknown. The aim of this study was to examine how nGER and snoring combined affected daytime sleepiness and involuntary falling asleep in women. Read More

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October 2018
1 Read

Long-term Results of Robotic Modified Belsey (Gastroesophageal Valvuloplasty) Fundoplication.

Surg Technol Int 2018 Nov 30;34. Epub 2018 Nov 30.

University of Arizona Medical Center, Tucson, AZ.

Purpose: Nissen fundoplication is associated with poor long-term durability, as well as dysphasia and gas bloat. We report here the long-term results of modified Belsey fundoplication (Gastroesophageal Valvuloplasty; GEV) performed laparoscopically using a surgical robot.

Methods: Patients who underwent robotic GEV were reviewed retrospectively. Read More

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November 2018
9 Reads

Omentopexy in Sleeve Gastrectomy Reduces Early Gastroesophageal Reflux Symptoms.

Surg Laparosc Endosc Percutan Tech 2018 Nov 28. Epub 2018 Nov 28.

Federal University of Pernambuco, Recife.

Introduction: Laparoscopic sleeve gastrectomy (LSG) is one of the surgical procedures indicated in the treatment of obesity. The occurrence of gastroesophageal reflux (GER) in the postoperative period of this surgery is related to a reduction in the lower esophageal sphincter (LES) tone and the presence of gastric residual fundus (RF) associated with increased gastric intraluminal pressure. Fixation of the remaining gastric reservoir to the gastrosplenic and gastrocolic ligaments (omentopexy) has emerged as a technical option to avoid or decrease GER in the postoperative period of LSG. Read More

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November 2018
3 Reads

Reintervention After Antireflux Surgery for Gastroesophageal Reflux Disease in England.

Ann Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery and Cancer, Imperial College London, London, UK.

Background: After antireflux surgery, highly variable rates of recurrent gastroesophageal reflux disease (GERD) have been reported.

Objective: To identify the occurrence and risk factors of recurrent GERD requiring surgical reintervention or medication.

Methods: The Hospital Episode Statistics database was used to identify adults in England receiving primary antireflux surgery for GERD in 2000 to 2012 with follow-up through 2014, and the outcome was surgical reintervention. Read More

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November 2018
5 Reads

Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy.

Int J Cancer 2018 Nov 29. Epub 2018 Nov 29.

Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Perioperative systemic treatment is standard of care for Caucasian patients with locally advanced, resectable gastric adenocarcinoma. The prognostic relevance of the microsatellite instability (MSI) status in patients undergoing neoadjuvant chemotherapy followed by resection is unclear. We analyzed the association of the MSI status with histological regression and clinical outcome in patients undergoing neoadjuvant systemic treatment. Read More

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November 2018
1 Read

Involvement of the TLR4/NF-κB Signaling Pathway in the Repair of Esophageal Mucosa Injury in Rats with Gastroesophageal Reflux Disease.

Cell Physiol Biochem 2018 29;51(4):1645-1657. Epub 2018 Nov 29.

Background/aims: Numerous studies have highlighted the activation of NF-κB in the esophageal mucosa during the early stages of gastroesophageal reflux disease (GERD). The present study aimed to investigate the role of the TLR4/NF-κB signaling pathway in GERD rat models.

Methods: Wistar rats (n = 60) were recruited to establish a GERD animal model. Read More

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November 2018
1 Read

An update on the latest chemical therapies for reflux esophagitis in children.

Expert Opin Pharmacother 2018 Nov 29:1-9. Epub 2018 Nov 29.

e Gastroenterology department , McGill University Health Centre , Montréal , Québec , Canada.

Introduction: Gastroesophageal reflux (GER), and its complicated form gastroesophageal reflux disease (GERD) is a common condition in infants and children. As GERD is often considered to cause extra-oesophageal symptoms in children and in the absence of standardized diagnostic and treatment algorithm, many children are inappropriately exposed to empirical anti-reflux treatments, with Acid-Suppressive Medications (ASM); mostly proton pump inhibitors (PPIs). Areas covered: The authors summarize the pharmacological management of pediatric GERD and discuss the efficacy of PPIs as randomized controlled trials have failed to demonstrate their clinical efficacy in the pediatric population. Read More

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November 2018
3 Reads

Outcomes of nutritional jejunostomy in the curative treatment of esophageal cancer.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Substantial weight loss and eating problems are common before and after esophagectomy for cancer. The use of jejunostomy might prevent postoperative weight loss, but studies evaluating other outcomes are scarce. This study aims to assess the influence of jejunostomy on postoperative health-related quality of life (HRQOL), complications, reoperation, hospital stay, and survival. Read More

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November 2018
5 Reads

The prevalence of gastroesophageal reflux disease in an adult, South African black population, and the association with obesity.

Minerva Gastroenterol Dietol 2018 Nov 27. Epub 2018 Nov 27.

National Health Laboratory Service, Department of Chemical Pathology, University of the Witwatersrand Medical School, Johannesburg, South Africa.

Background: The aim of the study was to determine the prevalence of gastroesophageal reflux disease (GORD) in a black population in South Africa and to determine if there was any association with obesity.

Methods: A sample of 312 black subjects was randomly selected and interviewed with a structured questionnaire (GerdQ) consisting of six questions translated into English and two of the most commonly used African languages (Zulu and Xhosa). This question-based symptom score for the diagnosis of GORD has been validated previously. Read More

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November 2018
1 Read

Effects of proton pump inhibitor on the human gut microbiome profile in multi-ethnic groups in Singapore.

Singapore Med J 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Introduction: The objectives of this study were to examine the effects of ethnicity, gender, and a proton pump inhibitor (PPI), omeprazole, on the human gut microbiome. PPIs are commonly used for the treatment of acid-related disorders. We hypothesised that PPI therapy might perturb microbial communities and alter the gut microbiome. Read More

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November 2018
2 Reads

Comparative Study of Alginate and Omeprazole in Symptomatic Treatment of Non-erosive Gastroesophageal Reflux Disease.

Mymensingh Med J 2018 Oct;27(4):771-775

Dr ANM Saifullah, Assistant Professor, Department of Gastroenterology, Sir Salimullah Medical College (SSMC), Dhaka, Bangladesh; E-mail: saifullahanm

Gastroesophageal reflux disease is widely reported most prevalent disease of the gastrointestinal tract. The burden of gastroesophageal reflux disease (GERD) is increasing in Asia and the majority of patients have non-erosive reflux disease. This prospective, open label, non random (consecutive), experimental study was performed due to compare the therapeutic efficacy of alginate and omeprazole in relieving symptoms of non erosive reflux disease (NERD) and was carried out in the Outpatient Department of Gastroenterology, Dhaka Medical College Hospital, Dhaka, Bangladesh from December 2013 to May 2014. Read More

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October 2018

[Esophageal motility and reflux characteristics in gastroesophageal reflux disease patients with or without extra-esophageal symptoms].

Zhonghua Yi Xue Za Zhi 2018 Nov;98(44):3579-3583

Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.

To investigate esophageal motility and reflux characteristics in gastroesophageal reflux disease (GERD) with and without extra-esophageal symptoms by high-resolution manometry and 24 h esophageal multichannel intraluminal impedance combined pH (MII-pH) monitoring. From February 2016 to June 2017, GERD patients with and without extra-esophageal symptoms were enrolled in this prospective controlled study. Esophageal HRM and 24 h MII-pH monitoring were performed. Read More

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November 2018
1 Read

Hospitalisation of adults with Down syndrome: lesson from a 10-year experience from a community hospital.

J Intellect Disabil Res 2018 Nov 28. Epub 2018 Nov 28.

Department of Internal Medicine, Metrowest Medical Center, Framingham, MA, USA.

Background: Life expectancy of individuals with Down syndrome (DS) has improved significantly over the past decades. However, there are sparse data documenting the co-morbidities and hospitalisation of adult patients with DS in the literature. The aim of this study was to characterise the co-morbidities and pattern of hospitalisation in adult patients with DS during a 10-year period at the community hospital as well as to compare hospitalisation parameters with the general adult population during the same years. Read More

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November 2018
1 Read

Revisional Gastric Bypass After Failed Adjustable Gastric Banding-One-Stage or Two-Stage Procedure?

Obes Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Background: Revisional laparoscopic Roux-en-Y gastric bypass (R-LRYGB) is the preferred procedure after failed adjustable gastric banding. Little is known about whether a one-stage procedure (one surgery for band removal and R-LRYGB) or a two-stage procedure (first band removal and later R-LRYGB) is superior. Aim of this study is to compare early- and long-term results of both methods at our institution. Read More

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November 2018

Neoadjuvant chemoradiotherapy or chemotherapy for gastroesophageal junction adenocarcinoma: A systematic review and meta-analysis.

Gastric Cancer 2018 Nov 27. Epub 2018 Nov 27.

Oncology Unit, Oncology Department, ASST Ospedale di Cremona, Viale Concordia 1, 26100, Cremona, Italy.

Objective: The preferred neoadjuvant treatment for gastroesophageal junction (GEJ) adenocarcinoma is still matter of debate. We conducted a meta-analysis to assess the different impact of neoadjuvant combined chemotherapy and radiotherapy (CTRT) versus chemotherapy (CT) alone.

Methods: A comprehensive search was performed in EMBASE, PubMed, and Cochrane Library databases from inception to 30th June 2018. Read More

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November 2018
2 Reads

Risk of small intestinal bacterial overgrowth in patients receiving proton pump inhibitors proton pump inhibitors plus prokinetics.

JGH Open 2018 Apr 2;2(2):47-53. Epub 2018 Apr 2.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Background And Aim: Intestinal dysmotility is considered a risk factor for small intestinal bacterial overgrowth (SIBO). Prokinetics improve intestinal motility and are often prescribed with proton pump inhibitors (PPIs) in patients with gastroesophageal reflux disease (GERD) and/or functional dyspepsia. The present study aimed to evaluate the prevalence of SIBO and the orocecal transit time (OCTT) in patients taking PPI compared with those taking PPI plus prokinetics. Read More

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April 2018
1 Read

Adiponectin level changes among Egyptians with gastroesophageal reflux disease.

JGH Open 2018 Feb 28;2(1):21-27. Epub 2018 Jan 28.

Department of Internal Medicine, Faculty of Medicine AL-Azhar University Assiut Egypt.

Background And Aim: Visceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.

Methods: In this study, 150 subjects were selected and divided into four groups: Group І ( = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ ( = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ ( = 40) were patients with severe erosive esophagitis; and finally, Group ІV ( = 20) were patients with Barrett's esophagus. Read More

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February 2018
3 Reads

Risk stratifying the screening of Barrett's esophagus: An Asian perspective.

JGH Open 2017 Oct 11;1(2):68-73. Epub 2017 Oct 11.

Department of Medicine National University Hospital Singapore.

Background And Aim: Barrett's esophagus (BE) is a premalignant condition for esophageal adenocarcinoma. Although risk factors exist for screening patients in the West, we aimed to determine the factors in terms of demographics and symptoms for patients in an Asian setting.

Methods: We recruited 1378 patients over a 7-year period as part of an ongoing gastric cancer screening program. Read More

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October 2017
1 Read

Ophthalmic Insert versus Eye Drops for Mydriasis in Neonates: A Randomized Clinical Trial.

Neonatology 2018 Nov 27;115(2):142-148. Epub 2018 Nov 27.

Data Mining International, Geneva, Switzerland.

Background: Eye drop treatment routinely used to obtain mydriasis prior to fundoscopy in neonates requires repeated instillations of mydriatic agents that can lead to systemic side effects.

Objectives: The aim of this study was to compare the mydriatic efficacy and tolerance of administration of phenylephrine and tropicamide via the ophthalmic insert Mydriasert® versus standard eye drop treatment in neonates.

Methods: In this prospective, single-blinded, noninferiority study, 80 hospitalized neonates (age < 18 months) requiring bilateral fundus examination were randomized to receive eye drops (repeated instillations of 2. Read More

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November 2018
4 Reads

The Present Status and Future of Barrett's Esophageal Adenocarcinoma in Japan.

Digestion 2018 Nov 27:1-6. Epub 2018 Nov 27.

Division of Gastroenterological Surgery, Tokai University, Oiso, Japan.

Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States.

Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6. Read More

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November 2018
3 Reads