1,744 results match your criteria Gastroenterology Clinics of North America[Journal]


New Developments in Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):xv-xvi. Epub 2018 Dec 13.

Celiac Disease Center at Columbia University, 180 Fort Washington Avenue, Suite 936, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.10.001DOI Listing

Celiac Disease, Gluten-Free, and Today's Fashionista.

Authors:
Alan L Buchman

Gastroenterol Clin North Am 2019 03 13;48(1):xiii-xiv. Epub 2018 Dec 13.

Intestinal Rehabilitation and Transplant Center, Department of Surgery, College of Medicine, The University of Illinois at Chicago, 840 South Wood Street, Suite 402 Clinical Sciences Building, MC 958 Chicago, IL 60612, USA; Health Care Services Corporation, 300 E. Randolph Street, Chicago, IL 60601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.10.002DOI Listing
March 2019
1 Read

(Outcome) Measure for (Intervention) Measures: A Guide to Choosing the Appropriate Noninvasive Clinical Outcome Measure for Intervention Studies in Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):85-99. Epub 2018 Dec 13.

Harvard Celiac Disease Research Program, Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA; Gastroenterology Therapeutic Area Research and Development, Takeda Pharmaceuticals, 40 Landsdowne Street, Boston, MA 02139, USA.

There is an unmet need for diagnostic and treatment interventions for celiac disease. Both clinical trials and real-world studies require careful selection of clinical outcome measures. Often, neither serology nor histology is an appropriate primary outcome. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368393PMC

Capsule Endoscopy and Enteroscopy in Celiac Disease.

Gastroenterol Clin North Am 2019 03 14;48(1):73-84. Epub 2018 Dec 14.

The University of Chicago, 5841 South Maryland Avenue, MC 4080 S401, Chicago, IL 60637, USA.

Celiac disease predominantly involves the proximal small bowel, but villus atrophy can be patchy, spare the duodenum, and be present more distally. Video capsule endoscopy is more sensitive than standard endoscopy to detect villus atrophy, and can define extent of disease, though it cannot obtain biopsies. Duodenal biopsy is the gold standard for diagnosis. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.005DOI Listing
March 2019
5 Reads

Nutritional Considerations of the Gluten-Free Diet.

Gastroenterol Clin North Am 2019 03 14;48(1):53-72. Epub 2018 Dec 14.

Division of Gastroenterology, Hepatology and Nutrition, Celiac Center, Boston Children's Hospital, 330 Longwood Avenue, Boston, MA 02215, USA.

Celiac disease (CD) is an autoimmune-related disease causing inflammation in the small intestine triggered by the ingestion of gluten in the diet. The gluten-free diet (GFD) is the only treatment. Nutritional deficiencies of macronutrients and micronutrients are frequently found in untreated or newly diagnosed CD. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.002DOI Listing

Biopsy Diagnosis of Celiac Disease: The Pathologist's Perspective in Light of Recent Advances.

Gastroenterol Clin North Am 2019 03 14;48(1):39-51. Epub 2018 Dec 14.

Columbia University, New York Presbyterian Hospital, 622 West 168th Street, VC14-228, New York, NY 10032, USA.

Celiac disease is a common immune-mediated disorder that occurs in individuals with permissive genetics (HLA-DQ2/DQ8 genotype) following exposure to certain wheat proteins. The histopathologic manifestations of small intestinal mucosal injury (villus atrophy, crypt hyperplasia, and intraepithelial lymphocytosis) are well recognized. However, these findings are not specific for celiac disease, because they are observed in other small intestinal disorders. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.003DOI Listing
March 2019
5 Reads

Celiac Disease: Clinical Features and Diagnosis.

Gastroenterol Clin North Am 2019 03 13;48(1):19-37. Epub 2018 Dec 13.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. Electronic address:

The presentation in celiac disease is shifting from the classical malabsorptive presentation to more nonclassical presentations, requiring clinicians to maintain a high level of suspicion for the disease and to be aware of the possible extraintestinal manifestations. The diagnosis of celiac disease is guided by initial screening with serology, followed by confirmation with an upper endoscopy and small intestinal biopsy. In some pediatric cases, biopsy may be avoided. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.001DOI Listing
March 2019
9 Reads

Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations.

Gastroenterol Clin North Am 2019 03 13;48(1):165-182. Epub 2018 Dec 13.

Department of Medicine, Columbia University Medical Center, 1130 Saint Nicholas Avenue, New York, NY 10032, USA; Celiac Disease Center, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY 10032, USA; Institute of Human Nutrition, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA. Electronic address:

Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364564PMC
March 2019
1 Read

Nondietary Therapies for Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):145-163. Epub 2018 Dec 13.

Division of Pediatric Gastroenterology and Nutrition, Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, 175 Cambridge Street, CPZS - 574, Boston, MA 02114, USA; Celiac Research Program, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address:

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten. Gluten-free diets can be challenging because of their restrictive nature, inadvertent cross-contaminations, and the high cost of gluten-free food. Novel nondietary therapies are at the preclinical stage, clinical trial phase, or have already been developed for other indications and are now being applied to CD. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.011DOI Listing
March 2019
14 Reads

Refractory Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):137-144. Epub 2018 Dec 13.

Paris Descartes University, 15 rue de l'Ecole de Médecine, Paris 75006, France; Gastroenterology Department, Hôpital Européen Georges Pompidou, APHP, 20 rue Leblanc, Paris 75015, France; UMR1163 Institute Imagine, 24 Boulevard du Montparnasse, Paris 75015, France.

Refractory celiac disease (RCD) refers to persistence of malnutrition and intestinal villous atrophy for more than 1 to 2 years despite strict gluten-free diet in patients with celiac disease. Diagnosis remains difficult and impacts treatment and follow-up. RCD has been subdivided into 2 subgroups according to the normal (RCDI) or abnormal phenotype of intraepithelial lymphocytes (IELs) (RCDII). Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.010DOI Listing

Follow-up of Celiac Disease.

Gastroenterol Clin North Am 2019 03 14;48(1):127-136. Epub 2018 Dec 14.

Hospital de Gastroenterología Dr. C. Bonorino Udaondo, Av. Caseros 2061, Buenos Aires 1236, Argentina.

Currently, the only effective treatment for celiac disease is complete removal of gluten from the diet. However, patients need to follow a strict gluten-free diet that results in symptomatic, serologic, and histologic remission in most patients. Histologic remission is usually complete in children, but recovery is slower and more frequently incomplete in adults. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.009DOI Listing
March 2019
5 Reads

The Microbiome in Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):115-126. Epub 2018 Dec 13.

Digestive and Liver Diseases, Columbia University, 180 Fort Washington, New York, NY 10032, USA. Electronic address:

The healthy microbiome is necessary for normal immune development in the gut. Alterations in the microbial makeup after a critical window increase the risk of autoimmunity, including celiac disease. Although this dysbiosis has been described in adult and pediatric patients, factors leading to dysbiosis are still being elucidated. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.008DOI Listing

Celiac Disease in Asia.

Gastroenterol Clin North Am 2019 03 13;48(1):101-113. Epub 2018 Dec 13.

Department of Pediatrics, Center for Celiac Research, Università Politecnica delle Marche, Piazzale Martelli Raffaele, 8, Ancona, Ancona 60121, Italy; Division of Pediatric Gastroenterology, Massachussets General Hospital, Boston, MA 33131, USA.

Celiac disease, once thought to be very uncommon in Asia, is now emerging in many Asian countries. Although the absolute number of patients with celiac disease at present is not very high, this number is expected to increase markedly over the next few years/decades owing to increasing awareness. It is now that the medical community across the Asia should define the extent of the problem and prepare to handle the impending epidemic of celiac disease in Asia. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.007DOI Listing
March 2019
1 Read

Epidemiology of Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):1-18. Epub 2018 Dec 13.

Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; University of Southern Denmark, Odense, Denmark.

Celiac disease is a common, chronic inflammatory disorder of the small intestine triggered by exposure to gluten in individuals with certain genetic types. This disorder affects people of any age or gender. Although often thought to be European in origin, it is now global in extent. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.004DOI Listing
March 2019
1 Read

Pediatric Gastroenterology.

Authors:
Robert J Shulman

Gastroenterol Clin North Am 2018 12 28;47(4):xv-xvi. Epub 2018 Sep 28.

Baylor College of Medicine, Children's Nutrition Research Center, Texas Children's Hospital, 1100 Bates Street, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.07.017DOI Listing
December 2018
1 Read

Pediatric Gastroenterology: Not Just Dealing with Little Adults.

Authors:
Alan L Buchman

Gastroenterol Clin North Am 2018 12;47(4):xiii-xiv

Intestinal Rehabilitation and Transplant Center, Department of Surgery, University of Illinois at Chicago, Suite 402 CSB, MC 958, 840 South Wood Street, Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.07.018DOI Listing
December 2018
12 Reads

Advances in Pediatric Fatty Liver Disease: Pathogenesis, Diagnosis, and Treatment.

Gastroenterol Clin North Am 2018 12 28;47(4):949-968. Epub 2018 Sep 28.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive North East, Atlanta, GA 30322, USA; Division of Gastroenterology, Hepatology, and Nutrition, Children's Healthcare of Atlanta, 1405 Clifton Road, Atlanta, GA 30329, USA.

Pediatric nonalcoholic fatty liver disease is an increasingly prevalent disease, but its pathophysiology is not fully elucidated, diagnosis is difficult and invasive, and therapeutic options are limited. This article addresses the recent advancements made in understanding the pathophysiology of nonalcoholic fatty liver disease, the development of less invasive diagnostic modalities, and emerging therapeutic options, including ongoing clinical trials in children. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.016DOI Listing
December 2018
14 Reads

Assessment and Treatment of Nonadherence in Transplant Recipients.

Gastroenterol Clin North Am 2018 12 28;47(4):939-948. Epub 2018 Sep 28.

Psychology, Fordham College at Rose Hill, Fordham University, 441 East Fordham Road, Dealy Hall, Bronx, NY 10458, USA.

Stable intake of an immunosuppressant medication regimen is essential for posttransplant survival in the vast majority of cases. And yet, many patients are nonadherent (do not take their medications as prescribed), and suffer consequences ranging from rejection to morbidity and mortality. We review the evidence related to monitoring of adherence to medications, and intervention strategies. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.015DOI Listing
December 2018
2 Reads

Molecular Mechanisms in Pediatric Cholestasis.

Gastroenterol Clin North Am 2018 12 28;47(4):921-937. Epub 2018 Sep 28.

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh, One Children's Hospital Drive, 6th Floor FP, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.

Pediatric cholestasis often results from mechanical obstruction of the biliary tract or dysfunction in the processes of forming and excreting bile. Various genetic defects with resulting molecular inaccuracies are increasingly being recognized, often with specific clinical characteristics. Identifying of the molecular abnormality can enable implementation of timely, appropriate treatment in some affected individuals and provide prognostic indicators for both families and care teams. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.014DOI Listing
December 2018
1 Read

Improving Care in Pediatric Inflammatory Bowel Disease.

Gastroenterol Clin North Am 2018 12 28;47(4):909-919. Epub 2018 Sep 28.

Department of Pediatrics, University of North Carolina at Chapel Hill, 230 MacNider, CB# 7229, Chapel Hill, NC 27599, USA; Department of Pathology, University of North Carolina at Chapel Hill, 230 MacNider, CB# 7229, Chapel Hill, NC 27599, USA.

Pediatric patients with inflammatory bowel disease (IBD) stand to benefit from quality improvement (QI) due to the chronic nature of the disease, frequent interaction with the health care system, and exposure to high-risk treatments. The use of QI in health care has led to significant improvements in quality and reliability of care. Despite these advances, significant deficits in providing high-quality pediatric IBD care persist. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.013DOI Listing
December 2018
11 Reads

Food Sensitivities: Fact Versus Fiction.

Gastroenterol Clin North Am 2018 12 5;47(4):895-908. Epub 2018 Oct 5.

Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA. Electronic address:

Food allergies are on the rise, for reasons that are not fully understood. However, there is a tendency to overestimate their frequency, mostly based on parents' reports or on the assumption that a positive skin or blood IgE test implies the existence of clinically relevant allergy. It is imperative to base food allergy diagnosis on well-defined criteria, avoiding "alternative" tests that are available to the general public. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.012DOI Listing
December 2018
3 Reads

Gastrointestinal Neuropathies: New Insights and Emerging Therapies.

Gastroenterol Clin North Am 2018 12 28;47(4):877-894. Epub 2018 Sep 28.

Neurogastroenterology and Motility Unit, Department of Pediatric Gastroenterology, Great Ormond Street Hospital, London WC1N 3JH, UK; Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

The bewildering complexity of the enteric nervous system makes it susceptible to develop a wide array of motility disorders, collectively called enteric neuropathies. These gastrointestinal conditions are among the most challenging to manage, mainly given poor characterization of their etiopathophysiology and outcomes. Not surprisingly, therefore, targeted or curative therapies for enteric neuropathies are lacking and management is largely symptomatic. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.011DOI Listing
December 2018
29 Reads

Integration of Biomedical and Psychosocial Treatments in Pediatrics Functional Gastrointestinal Disorders.

Gastroenterol Clin North Am 2018 12 28;47(4):863-875. Epub 2018 Sep 28.

Department of Clinical Research, College of Pharmacy & Health Sciences, Campbell University, PO Box 1090, 180 Main Street, Buies Creek, NC 27506, USA.

Pediatric functional gastrointestinal disorders (FGIDs) are disorders of the brain-gut axis. Pathophysiological factors include alterations in gut motility, microbiota, immune system, central nervous system, and psychosocial factors. Given the complex pathophysiology of FGIDs, many patients are in need of integrative treatment approaches that may include a combination of biomedical, nutritional, and psychological approaches. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.010DOI Listing
December 2018
14 Reads

Constipation: Beyond the Old Paradigms.

Gastroenterol Clin North Am 2018 12 28;47(4):845-862. Epub 2018 Sep 28.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, 3030 Children's Way, San Diego, CA 92123, USA.

Constipation is a common problem in children. Although most children respond to conventional treatment, symptoms persist in a minority. For children with refractory constipation, anorectal and colonic manometry testing can identify a rectal evacuation disorder or colonic motility disorder and guide subsequent management. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.009DOI Listing
December 2018
2 Reads

Infantile Colic: New Insights into an Old Problem.

Gastroenterol Clin North Am 2018 12 28;47(4):829-844. Epub 2018 Sep 28.

Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The University of Texas Health Science Center at Houston McGovern Medical School, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA. Electronic address:

Infant colic is a characteristic group of behaviors seen in young infants. The most prominent feature is prolonged crying. Additional characteristics, including clenching of the fists and flexion of the hips, have led to the suggestion that these behaviors are related to abdominal discomfort. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.008DOI Listing
December 2018
2 Reads
2.824 Impact Factor

New Insights into the Pathogenesis and Treatment of Malnutrition.

Gastroenterol Clin North Am 2018 12 28;47(4):813-827. Epub 2018 Sep 28.

Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Feigin Tower, 1102 Bates Avenue, Suite 860, Houston, TX 77030, USA. Electronic address:

The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.007DOI Listing
December 2018
12 Reads

Multiplex Nucleic Acid Amplification Testing to Diagnose Gut Infections: Challenges, Opportunities, and Result Interpretation.

Gastroenterol Clin North Am 2018 12 29;47(4):793-812. Epub 2018 Sep 29.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Washington University in St. Louis School of Medicine, 660 South Euclid Avenue, CB 8208, St Louis, MO 63110, USA. Electronic address:

Multiplex nucleic acid testing is increasingly used to diagnose childhood gastroenteritis. The advantages of this disruptive technology include rapidity, sensitivity, and ability to detect pathogenic viruses, bacteria, and parasites simultaneously. The drawbacks are its capacity to identify organisms of uncertain clinical significance in North American children, cost, and inability to provide viable bacteria for strain typing by public health authorities. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.006DOI Listing
December 2018
1 Read

Gastrointestinal Development: Implications for Management of Preterm and Term Infants.

Gastroenterol Clin North Am 2018 12 28;47(4):773-791. Epub 2018 Sep 28.

Department of Pediatrics, University of Florida, 6516 Southwest 93rd Avenue, Gainesville, FL 32610, USA. Electronic address:

The gastrointestinal (GI) system provides digestive, absorptive, neuroendocrine, and immunologic functions to support overall health. If normal development is interrupted, a variety of complications and disease can arise. This article explores normal development of the GI tract and specific clinical challenges pertinent to preterm and term infants. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.005DOI Listing
December 2018
13 Reads

Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us.

Gastroenterol Clin North Am 2018 12 4;47(4):755-772. Epub 2018 Oct 4.

Department of Biochemistry, Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Pediatrics, Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Gastroenterology, Hepatology and Nutrition, Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, SickKids, Inflammatory Bowel Disease Centre, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. Electronic address:

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, of which ulcerative colitis and Crohn's disease are the 2 most prevailing entities. Very early onset IBD (VEO-IBD) children diagnosed with IBD under age 6 years. Although the etiology of IBD is mostly unknown, it involves a complex interaction among host genetics, microbiota, environmental factors, and aberrant immune responses. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.004DOI Listing
December 2018
12 Reads

Pediatric Pancreatitis-Molecular Mechanisms and Management.

Gastroenterol Clin North Am 2018 12 4;47(4):741-753. Epub 2018 Oct 4.

Pediatric Gastroenterology, Hepatology and Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, MPRB 4th Floor, Campus Box 8208, St Louis, MO 63110, USA. Electronic address:

Pediatric pancreatitis is an emerging field with an increasing incidence of disease. Management of pediatric pancreatitis is understudied and, therefore, extrapolated from adult studies (although the etiologies are different). There is evidence that feeding is safe in mild acute pancreatitis in children without increased pain or length of stay. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.003DOI Listing
December 2018
2 Reads

Brain-Gut Axis: Clinical Implications.

Gastroenterol Clin North Am 2018 12 28;47(4):727-739. Epub 2018 Sep 28.

Department of Pediatrics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 17, New York, NY 10032, USA. Electronic address:

This article provides an overarching view of what is currently known about the physiology of the brain-gut axis in both health and disease and how these concepts apply to irritable bowel syndrome, the most common functional gastrointestinal disorder in pediatrics. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.002DOI Listing
December 2018
2 Reads

Update on Dietary Management of Childhood Functional Abdominal Pain Disorders.

Gastroenterol Clin North Am 2018 12 28;47(4):715-726. Epub 2018 Sep 28.

Department of Pediatrics, Baylor College of Medicine, 6701 Fannin Street, MWT 1010.03, Houston, TX, USA. Electronic address:

Diet plays a significant role for children with functional abdominal pain disorders. A large majority of these children identify at least 1 food that exacerbates their symptoms. Malabsorbed carbohydrates may have both direct and microbiome-mediated physiologic effects. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.07.001DOI Listing
December 2018
6 Reads

Gastrointestinal Imaging: Rapid Advancements Leading to Improved Patient Care.

Gastroenterol Clin North Am 2018 09;47(3):xv-xvii

Abdominal Imaging Section, Department of Radiology, University of Wisconsin School of Medicine & Public Health, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.04.014DOI Listing
September 2018
1 Read

Diagnostic Imaging: A Peephole into Many of the Body's Dressing Rooms.

Authors:
Alan L Buchman

Gastroenterol Clin North Am 2018 Sep 29;47(3):xiii-xiv. Epub 2018 Jun 29.

Professor of Clinical Surgery, Medical Director, Intestinal Rehabilitation and Transplant Center, University of Illinois at Chicago, Medical Director, Health Care Services Corporation, Chicago, Illinois, USA; 959 Oak Drive, Glencoe, IL 60022, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.04.015DOI Listing
September 2018
17 Reads

PET/MRI for Gastrointestinal Imaging: Current Clinical Status and Future Prospects.

Gastroenterol Clin North Am 2018 09 7;47(3):691-714. Epub 2018 Jul 7.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

Positron emission tomography (PET)/computed tomography (CT) with 2-deoxy-2-[F]fluoro-d-glucose (FDG) has become the standard of care for the initial staging and subsequent treatment response assessment for numerous gastrointestinal malignancies. However, it is often supplemented by magnetic resonance imaging (MRI) for local tumor staging. Hybrid PET/MRI scanners, which acquire PET data and MRI data simultaneously, have the potential to provide accurate whole-body staging in a single examination. Read More

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September 2018
4 Reads

MRI of the Nontraumatic Acute Abdomen: Description of Findings and Multimodality Correlation.

Gastroenterol Clin North Am 2018 Sep 7;47(3):667-690. Epub 2018 Jul 7.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-3252, USA.

Obtaining a specific diagnosis in the nontraumatic acute abdomen can be clinically challenging, because a wide range of disease processes affecting a number of different organ systems may have very similar presentations. Although computed tomography and ultrasound examination are the imaging tests most commonly used to evaluate the acute abdomen, MRI can often offer comparable diagnostic performance, and may be considered when other modalities are equivocal, suboptimal, or contraindicated. In some circumstances, MRI is emerging as an appropriate first-line imaging test. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.010DOI Listing
September 2018
20 Reads

Splenomegaly: A Combined Clinical and Radiologic Approach to the Differential Diagnosis.

Gastroenterol Clin North Am 2018 Sep 7;47(3):643-666. Epub 2018 Jul 7.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

An enlarged spleen (splenomegaly) is a common imaging finding and may be related to a broad array of underlying conditions. The multifaceted functions of the spleen make it susceptible to involvement by a variety of pathophysiologic processes. Understanding these conditions and incorporating all relevant clinical and radiologic data allow narrowing the differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.009DOI Listing
September 2018
2 Reads

Percutaneous Biliary Interventions.

Gastroenterol Clin North Am 2018 Sep 7;47(3):621-641. Epub 2018 Jul 7.

Memorial Sloan Kettering Cancer Center, Weill Cornell Medical Center, 1275 York Avenue, H-118, New York, NY 10065, USA. Electronic address:

Biliary drainage is important in the care of patients with benign and malignant biliary obstruction. Careful preprocedure evaluation of high-quality cross-sectional imaging and inventory of symptoms are necessary to determine whether a percutaneous, endoscopic, or surgical approach is most appropriate. High bile duct obstruction is usually best managed percutaneously; a specific duct can be targeted and enteric contamination of isolated ducts can be avoided. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.008DOI Listing
September 2018
1 Read

Imaging in Autoimmune Pancreatitis and Immunoglobulin G4-Related Disease of the Abdomen.

Gastroenterol Clin North Am 2018 Sep 7;47(3):603-619. Epub 2018 Jul 7.

Department of Radiology, Mayo Clinic School of Medicine, Mayo Clinic Hospital, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Autoimmune pancreatitis (AIP) is steroid-responsive fibroinflammatory disorder of the pancreas. There are 2 distinct subtypes of AIP, types 1 and 2. Type 1 is associated with systemic immunoglobulin (Ig)G4 disease and may affect multiple organs in the body. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.007DOI Listing
September 2018
2 Reads

Role of Imaging in Surveillance and Diagnosis of Hepatocellular Carcinoma.

Gastroenterol Clin North Am 2018 Sep 7;47(3):585-602. Epub 2018 Jul 7.

Body Imaging Section and Fellowship Program, MRI, Department of Radiology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 800, Chicago, IL 60611, USA. Electronic address:

The prognosis for hepatocellular carcinoma (HCC) is dependent on tumor stage at diagnosis, with curative treatment options more available to early-detected HCCs. Professional organizations have produced HCC screening guidelines in at-risk groups, with ultrasound the most commonly used screening tool and increased interest in MRI in specific populations. HCC may be diagnosed by imaging features alone and have been universally incorporated into management guidelines. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183004
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http://dx.doi.org/10.1016/j.gtc.2018.04.013DOI Listing
September 2018
23 Reads

Multidetector Computed Tomography for Retrospective, Noninvasive Staging of Liver Fibrosis.

Gastroenterol Clin North Am 2018 09 7;47(3):569-584. Epub 2018 Jul 7.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792, USA.

Although not traditionally used to assess hepatic fibrosis, computed tomography (CT) is fast, accessible, robust, and commonly used for abdominal indications. CT metrics are often easily retrospectively obtained without special equipment. Metrics such as liver segmental volume ratio, which quantifies regional hepatic volume changes; splenic volume; and liver surface nodularity scoring show diagnostic performance comparable to elastography techniques for detecting significant and advanced fibrosis. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.012DOI Listing
September 2018
6 Reads

Defecography: An Overview of Technique, Interpretation, and Impact on Patient Care.

Gastroenterol Clin North Am 2018 Sep 7;47(3):553-568. Epub 2018 Jul 7.

Department of Radiology, University of Wisconsin School of Medicine & Public Health, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address:

Pelvic floor and defecatory dysfunction are common in the female patient population. When combined with physical examination, barium defecography allows for accurate and expanded assessment of the underlying pathology and helps to guide future intervention. Understanding the imaging findings of barium defecography in the spectrum of pathology of the anorectum and pelvic floor allows one to appropriately triage and treat patients presenting with defecatory dysfunction. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.006DOI Listing
September 2018
26 Reads

Rectal MRI for Cancer Staging and Surveillance.

Gastroenterol Clin North Am 2018 Sep 29;47(3):537-552. Epub 2018 Jun 29.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1365-A Clifton Road Northeast, Suite AT-627, Atlanta, GA 30322, USA.

MRI is an integral part of the multidisciplinary treatment of rectal adenocarcinoma. Staging MRI is performed to establish TNM stage and assess for prognostic factors, including circumferential resection margin status and presence of extramural vascular invasion. The results of staging MRI determine which patients will undergo preoperative neoadjuvant chemoradiation before resection. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.005DOI Listing
September 2018
1 Read
2.824 Impact Factor

The Natural History of Colorectal Polyps: Overview of Predictive Static and Dynamic Features.

Gastroenterol Clin North Am 2018 09 29;47(3):515-536. Epub 2018 Jun 29.

University of Wisconsin School of Medicine & Public Health, 600 Highland Avenue, Madison, WI, 53793 USA.

For decades, colorectal screening strategies have been largely driven by static features, particularly polyp size. Although cross-sectional features of polyp size, morphology, and location are important determinants of clinical relevance before histology, they lack any dynamic information on polyp growth rates. Computed tomography colonography allows for in vivo surveillance of colorectal polyps, providing volumetric growth rates that are providing new insights into tumorigenesis. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100796PMC
September 2018
2 Reads

Radiologic Assessment of Gastrointestinal Bleeding.

Gastroenterol Clin North Am 2018 Sep 7;47(3):501-514. Epub 2018 Jul 7.

Department of Radiology, Boston University Medical Center, 820 Harrison Avenue FGH Building, 3rd Floor, Boston, MA 02118, USA.

Gastrointestinal (GI) bleeding represents a broad differential of disease throughout the GI tract. The proper diagnostic evaluation of patients presenting with symptoms of GI bleeding depends on the overall clinical acuity and suspected source locations. The radiologic assessment of these patients is centered around computed tomography (CT) angiography, CT enterography, conventional angiography, and nuclear scintigraphy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183003
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http://dx.doi.org/10.1016/j.gtc.2018.04.003DOI Listing
September 2018
8 Reads

Computed Tomography and Magnetic Resonance Small Bowel Enterography: Current Status and Future Trends Focusing on Crohn's Disease.

Gastroenterol Clin North Am 2018 Sep 7;47(3):475-499. Epub 2018 Jul 7.

Department of Radiology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA.

Computed tomography enterography (CTE) and magnetic resonance enterography (MRE) are presently state-of-the-art radiologic tests used to examine the small bowel for various indications. This article focuses on CTE and MRE for the evaluation of Crohn disease. The article describes recent efforts to achieve more standardized interpretation of CTE and MRE, summarizes recent research studies investigating the role and impact of CTE and MRE more directly for several different clinical and research issues beyond general diagnostic accuracy, and provides an update on progress in imaging techniques. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.002DOI Listing
September 2018
8 Reads

Ten Questions About Barium Esophagography and Dysphagia.

Authors:
Marc S Levine

Gastroenterol Clin North Am 2018 Sep 7;47(3):449-473. Epub 2018 Jul 7.

Department of Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

The barium esophagogram is a global test for patients with dysphagia that can simultaneously detect morphologic abnormalities in the pharynx and esophagus, pharyngeal swallowing dysfunction, esophageal dysmotility, and gastroesophageal reflux. The barium esophagram is an inexpensive, noninvasive, and widely available procedure that can serve as the initial diagnostic test for dysphagia and facilitate selection of other diagnostic studies such as endoscopy. This article addresses 10 questions about barium esophagography and dysphagia that should help gastroenterologists gain a better perspective about the utility of barium studies in this clinical setting. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.001DOI Listing
September 2018
1 Read

Gastrointestinal Transplantation.

Gastroenterol Clin North Am 2018 Jun 4;47(2):xv-xvi. Epub 2018 Apr 4.

Division of Transplantation, Department of Surgery, The University of Illinois at Chicago, College of Medicine, 840 South Wood Street, Suite 402 (MC958), Chicago, IL 60612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.01.014DOI Listing
June 2018
3 Reads

Transplantation of Abdominal Organs.

Authors:
Alan L Buchman

Gastroenterol Clin North Am 2018 Jun;47(2):xiii-xiv

Intestinal Rehabilitation and Transplant Center, Department of Surgery, College of Medicine, The University of Illinois at Chicago, 840 South Wood Street, Suite 402 Clinical Sciences Building, MC 958, Chicago, IL 60612, USA; Health Care Services Corporation, 300 E. Randolph Street, Chicago, IL 60601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.01.015DOI Listing
June 2018
2 Reads

Robotic Pancreas Transplantation.

Gastroenterol Clin North Am 2018 Jun 4;47(2):443-448. Epub 2018 Apr 4.

Department of Surgery, Division of Transplantation, University of Virginia, Health System, Transplant Center, 1300 Jefferson Park Avenue, Fourth Floor, Charlottesville, VA 22903, USA.

Obesity is considered a relative contraindication to pancreas transplantation due to an overall increased risk in wound-related complications and surgical site infections. The rationale for performing pancreas transplantation in a minimally invasive fashion is to reduce these risks, which can be associated with inferior patient and graft survival following pancreas transplantation in morbidly obese patients. At the University of Illinois at Chicago, the initial series of robotic-assisted pancreas transplantation in obese patient with type 1 and 2 diabetes has been performed. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.01.010DOI Listing
June 2018
3 Reads