218,113 results match your criteria Gastroenterology & Hepatology [Journal]


Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Hepato-gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. Electronic address:

Background And Aim: Chronic liver diseases are characterized by expansion of the small immature cholangiocytes - a mechanism named ductular reaction (DR) - which have the capacity to differentiate in hepatocytes. We investigated the kinetics of DR differentiation into hepatocytes as well as several important features as functional maturity, clonal expansion and resistant to stress of the newly formed hepatocytes in mice with long-term liver damage.

Methods: We tracked cholangiocytes using osteopontin-iCreER and hepatocytes with AAV8-TBG-Cre. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.003DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

TEA domain transcription factor 4 (TEAD4) is the major mediator of Yap oncogenic activity in mouse and human hepatoblastoma.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA. Electronic address:

Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of Yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA domain (TEAD) proteins. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.016DOI Listing
February 2019

Reply.

Gastroenterology 2019 Feb 19. Epub 2019 Feb 19.

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1053/j.gastro.2019.02.026DOI Listing
February 2019

Reply.

Gastroenterology 2019 Feb 19. Epub 2019 Feb 19.

Divisions of Gastroenterology; Research and Development, Veterans Affairs Puget Sound Healthcare System, Seattle WA.

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http://dx.doi.org/10.1053/j.gastro.2019.02.024DOI Listing
February 2019

The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice.

Endocrinology 2019 Feb 22. Epub 2019 Feb 22.

Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.

Glucocorticoids (Gcs) are potent and widely used medicines, but often cause metabolic side effects. A murine model of corticosterone (Cort) treatment results in increased hypothalamic expression of the melanocortin antagonist AgRP in parallel with obesity and hyperglycaemia. This study investigates how these adverse effects develop over time with particular emphasis on hypothalamic involvement. Read More

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http://dx.doi.org/10.1210/en.2019-00018DOI Listing
February 2019

Renal iron accumulation and oxidative injury with aging: effects of treatment with an iron chelator.

J Gerontol A Biol Sci Med Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Health and Human Physiology, The University of Iowa.

Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed the effects of short-term iron chelation on markers of iron status, oxidative stress, inflammation, and autophagy in the kidneys of old rats. Old Fischer 344 rats (24 mo) were treated with deferoxamine (DFO; 200 mg/kg, twice daily for 4. Read More

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http://dx.doi.org/10.1093/gerona/glz055DOI Listing
February 2019

Potential Functional Variants in SMC2 and TP53 in the AURORA Pathway Genes and Risk of Pancreatic Cancer.

Carcinogenesis 2019 Feb 22. Epub 2019 Feb 22.

Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.

The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To test this hypothesis, we used three large, publically available pancreatic cancer genome-wide association studies (GWASs) datasets (PanScan I, II/III and PanC4) to assess the associations of 7,168 single nucleotide polymorphisms (SNPs) in a set of 62 genes of this pathway with pancreatic cancer risk (8,477 cases and 6,946 controls of European ancestry). Read More

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http://dx.doi.org/10.1093/carcin/bgz029DOI Listing
February 2019

Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model.

PLoS One 2019 22;14(2):e0212860. Epub 2019 Feb 22.

Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, Australia.

Liver cancer is a poor prognosis cancer with limited treatment options. To develop a new therapeutic approach, we derived HCC cells from a known model of murine hepatocellular carcinoma (HCC). We treated adiponectin (APN) knock-out mice with the carcinogen diethylnitrosamine, and the resulting tumors were 7-fold larger than wild-type controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212860PLOS
February 2019

Resistance towards metronidazole in Blastocystis sp.: A pathogenic consequence.

PLoS One 2019 22;14(2):e0212542. Epub 2019 Feb 22.

Depatment of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Blastocsytis sp. is a protozoan parasite that has been linked to common gastrointestinal illnesses. Metronidazole, the first line therapy, was reported to show frequent inefficacy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212542PLOS
February 2019

Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation.

PLoS One 2019 22;14(2):e0212589. Epub 2019 Feb 22.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.

Hepatic stellate cells (HSCs) were reported to promote the progression of hepatocellular carcinoma (HCC), however its mechanism is uncertain. We previously reported that protein kinase R (PKR) in hepatocytes regulated HCC proliferation. In this study, we focused on the role of PKR in HSCs, and clarified the mechanism of its association with HCC progression. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212589PLOS
February 2019

New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement.

PLoS One 2019 22;14(2):e0212427. Epub 2019 Feb 22.

Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.

Background And Aims: Various studies have been previously conducted on the diagnosis of lymphadenopathy as benign or malignant, but the results vary. These studies did not describe the inter-rater agreement on the EUS features of lymphadenopathy. In this study, we evaluate the inter-rater agreement on EUS features and propose EUS diagnostic norms for lymphadenopathy based on inter-rater agreement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212427PLOS
February 2019

Metagenomic analyses of the gut microbiota associated with colorectal adenoma.

PLoS One 2019 22;14(2):e0212406. Epub 2019 Feb 22.

Division of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan.

Recent studies have suggested an association between certain members of the Fusobacterium genus, especially F. nucleatum, and the progression of advanced colorectal carcinoma (CRC). We assessed such an association of the gut microbiota in Japanese patients with colorectal adenoma (CRA) or intramucosal CRC using colonoscopy aspirates. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212406PLOS
February 2019

Cost-effectiveness Analysis of Bariatric Surgery for Patients With Nonalcoholic Steatohepatitis Cirrhosis.

JAMA Netw Open 2019 Feb 1;2(2):e190047. Epub 2019 Feb 1.

Division of Digestive and Liver Diseases, Department of Medicine,Columbia University Medical Center, New York, New York.

Importance: Obesity is the most common risk factor for nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease that can lead to cirrhosis and hepatocellular carcinoma. Weight loss can be an effective treatment for obesity and may slow the progression of advanced liver disease.

Objective: To assess the cost-effectiveness of bariatric surgery in patients with NASH and compensated cirrhosis. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.0047DOI Listing
February 2019

Management of Biological Therapy Before Elective Inflammatory Bowel Disease Surgeries.

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Increasing uptake of biologic therapy has contributed to declining surgical rates for inflammatory bowel disease (IBD). However, a significant number of patients on biologic therapy will go on to require surgery. The literature is conflicted with regard to the preoperative management of biologic therapy before urgent or elective IBD surgery. Read More

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http://dx.doi.org/10.1093/ibd/izz002DOI Listing
February 2019

Adalimumab for patients with Crohn's disease complicated by intra-abdominal abscess: a multicentre, prospective, observational cohort study.

J Crohns Colitis 2019 Jan;13(Supplement_1):S616

Beaujon University Hospital, Gastroenterology, Clichy, France.

doi:10.1093/ecco-jcc/jjy222 Abstract P528 from the 'Poster presentations' section of the main abstract book has been withdrawn and re-inserted as DOP63 in the 'Late-breaking abstracts' section. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz045DOI Listing
January 2019

Whole Exome Sequencing of Ulcerative Colitis-associated Colorectal Cancer Based on Novel Somatic Mutations Identified in Chinese Patients.

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

Department of Gastroenterology, Key Laboratory of Gut Microbiota Translational Medicine Research, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Beijing, China.

Background: Carcinogenesis is a severe consequence of chronic ulcerative colitis. We investigated the somatic mutations and pathway alterations in ulcerative colitis-associated colorectal cancer (CRC) in Chinese patients compared with sporadic CRCs to reveal potential therapeutic targets in ulcerative colitis-associated CRC.

Methods: Whole exome sequencing was performed on archival tumor tissues and paired adjacent nondysplastic mucosa from 10 ulcerative colitis-associated CRC patients at a high risk of carcinogenesis. Read More

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http://dx.doi.org/10.1093/ibd/izz020DOI Listing
February 2019

Progress of Exosomes in the Diagnosis and Treatment of Pancreatic Cancer.

Genet Test Mol Biomarkers 2019 Feb 22. Epub 2019 Feb 22.

1 Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, P.R. China.

Pancreatic cancer (PC) is a digestive system tumor that is highly malignant, with an increasing incidence rate, poor prognosis, and a low 5-year survival rate. The overwhelming majority of patients with PC are in an advanced stage at the time of diagnosis and have lost the opportunity for radical surgery. The efficacy of radiotherapy and chemotherapy for PC is very poor. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0235DOI Listing
February 2019

Airborne allergen, allergy & atopic IBS.

Neurogastroenterol Motil 2019 Mar;31(3):e13517

Division of Gastroenterology & Hepatology, University Medicine Cluster, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1111/nmo.13517DOI Listing

Letter to the editors: Measuring LES and UES basal pressure.

Neurogastroenterol Motil 2019 Mar;31(3):e13502

Department of Gastroenterology and Hepatology, Amsterdam Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/nmo.13502DOI Listing

Deliberations more than a cut-off HBsAg value for Nuc cessation.

Hepatology 2019 Feb 22. Epub 2019 Feb 22.

Chang Gung University College of Medicine, Taiwan.

We agree with the conclusion of the systemic review by Liu J et al.(1) that end of treatment (EOT) quantitative HBsAg (qHBsAg) < 100 IU/ml could be a level for stopping nucleos(t)ide analuges therapy. However, we were surprised that: (A), several important off-therapy studies meeting authors' selection criteria were neglected (Chen CH CGH 2015; Hsu YC CGH 2016; Wang CC AJG 2016; online by 2017/12: Tseng CH J Formos Med Assoc 2018). Read More

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http://dx.doi.org/10.1002/hep.30576DOI Listing
February 2019

Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting.

Ann Rheum Dis 2019 Feb 6. Epub 2019 Feb 6.

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background And Objective: Systemic sclerosis (SSc) is a severe autoimmune disease, in which the pathogenesis is dependent on both genetic and epigenetic factors. Altered gene expression in SSc monocytes, particularly of interferon (IFN)-responsive genes, suggests their involvement in SSc development. We investigated the correlation between epigenetic histone marks and gene expression in SSc monocytes. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214295DOI Listing
February 2019

Easy surveillance of muscle volume decline in chronic liver disease patients using finger-circle (yubi-wakka) test.

J Cachexia Sarcopenia Muscle 2019 Feb 21. Epub 2019 Feb 21.

Gastroenterology Center, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, 790-0024, Japan.

Background: Muscle atrophy (MA) and muscle strength decline are important clinical features in chronic liver disease (CLD) patients. An easy to perform MA screening method without need for special equipment would be helpful. We evaluated the usefulness of the previously reported finger-circle test as screening for MA in CLD patients. Read More

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http://dx.doi.org/10.1002/jcsm.12392DOI Listing
February 2019

Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases.

Pediatr Transplant 2019 Feb 21:e13379. Epub 2019 Feb 21.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Database linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart-lung, and small bowel transplants. Read More

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http://dx.doi.org/10.1111/petr.13379DOI Listing
February 2019

Post-transplant metabolic syndrome in children: Know better to cure better.

Pediatr Transplant 2019 Feb 21:e13367. Epub 2019 Feb 21.

Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Gesù Children's Research Hospital IRCCS, Rome, Italy.

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http://dx.doi.org/10.1111/petr.13367DOI Listing
February 2019

Sacral nerve modulation for irritable bowel syndrome: A randomized, double-blinded, placebo-controlled crossover study.

Neurogastroenterol Motil 2019 Feb 21:e13570. Epub 2019 Feb 21.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Background: Irritable bowel syndrome (IBS) is among the most common gastrointestinal disorders, and a substantial proportion of patients have an insufficient response to treatment. In a single-blinded study, sacral nerve modulation (SNM) significantly reduced symptoms of IBS. The aim of the present double-blinded, randomized, placebo-controlled study was to evaluate the effect of SNM for IBS. Read More

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http://dx.doi.org/10.1111/nmo.13570DOI Listing
February 2019

Activation of cannabinoid 2 receptor relieves colonic hypermotility in a rat model of irritable bowel syndrome.

Neurogastroenterol Motil 2019 Feb 21:e13555. Epub 2019 Feb 21.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Irritable bowel syndrome (IBS) is a common disease with intestinal dysmotility, whose mechanism remains elusive. The endocannabinoid system is emerging as an important modulator of gastrointestinal (GI) motility in multiple diseases, but its involvement in IBS is unknown. We aimed to determine whether cannabinoid 2 (CB2) receptor modulates intestinal motility associated with stress-induced IBS. Read More

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http://dx.doi.org/10.1111/nmo.13555DOI Listing
February 2019

Efficacy, long-term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan.

Neurogastroenterol Motil 2019 Feb 21:e13571. Epub 2019 Feb 21.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Background: In two phase 3 trials, elobixibat, a locally acting ileal bile acid transporter inhibitor, resolved constipation and was well tolerated in Japanese patients with chronic constipation. We analyzed the efficacy, safety, and impact on quality of life (QOL) of elobixibat in patients with symptomatically more severe constipation in the two phase 3 trials.

Methods: This post hoc analysis of elobixibat treatment outcomes included data from a 2-week, randomized, placebo-controlled, phase 3 trial (10 mg/d), and a 52-week, open-label trial (5-15 mg/d) in subgroups with severe constipation defined as ≤2 spontaneous bowel movements (SBMs) and ≤3 Bristol Stool Form Scale score during the second week of the 2-week run-in period. Read More

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http://dx.doi.org/10.1111/nmo.13571DOI Listing
February 2019

First two cases of Zenker's diverticulum treated with flexible endoscopic septum division in Japan.

Dig Endosc 2019 Feb 21. Epub 2019 Feb 21.

Gastroenterology Department, Dudley Group Hospitals, Birmingham City University, Birmingham, United Kingdom.

Flexible endoscopic septum division (FESD) is emerging as an effective minimally invasive treatment for Zenker's diverticulum (ZD). Overall prevalence of ZD is rare. Therefore, ZD was historically treated by surgery, and there are no reports of FESD for ZD in Japan to date. Read More

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http://dx.doi.org/10.1111/den.13378DOI Listing
February 2019

Kidney Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity.

Transpl Int 2019 Feb 21. Epub 2019 Feb 21.

Organ Transplantation Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Inflammatory Bowel Diseases (IBD) is a systemic disorder with possible renal involvement, yet data regarding the outcome of kidney transplantation (KT) in those patients, and IBD course post KT, are scarce. In this retrospective analysis, we studied the outcome of 12 IBD kidney recipients (7 Crohn's disease, 5 ulcerative colitis; primary kidney disease was IgA nephropathy in 5, polycystic disease in 4), compared to two control groups: matched-controls, and a cohort of recipients with similar kidney disease. During a follow-up period of 60. Read More

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http://dx.doi.org/10.1111/tri.13415DOI Listing
February 2019

Splenic arterial injury caused by use of a lumen-apposing metal stent for walled-off pancreatic necrosis drainage.

Dig Endosc 2019 Feb 21. Epub 2019 Feb 21.

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa, 761-0793, Japan.

Walled-off pancreatic necrosis (WON) is a severe complication of acute necrotizing pancreatitis with pancreatic fluid collection. Endoscopic ultrasound (EUS)-guided drainage has been proposed as first-line treatment for WON. A newly developed lumen-apposing metal stent (LAMS) was recently introduced for WON drainage. Read More

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http://dx.doi.org/10.1111/den.13376DOI Listing
February 2019

Nucleolar spindle-associated protein 1 promotes tumorigenesis and predicts poor prognosis in human esophageal squamous cell carcinoma.

J Cell Biochem 2019 Feb 21. Epub 2019 Feb 21.

Department of Gastroenterology and Hepatology, Nantong Institute of Liver Disease, Nantong Third People's Hospital Affiliated to Nantong University, Nantong, Jiangsu, China.

The microtubule binding protein, nucleolar spindle-associated protein 1 (NUSAP1), has a crucial function in mitosis and its expression is closely associated with carcinogenesis. Herein, we aimed to determine the function of NUSAP1 in the development of human esophageal squamous cell carcinoma (ESCC), and the association of NUSAP1 expression with ESCC. Immunohistochemical staining of ESCC tissue sections indicated that NUSAP1 was expressed to a higher degree in tumor tissues than in adjacent nontumor tissues. Read More

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http://dx.doi.org/10.1002/jcb.28452DOI Listing
February 2019

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy.

J Inherit Metab Dis 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatric Neurology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Introduction: Currently, no therapies are available for Zellweger spectrum disorders (ZSDs), a group of genetic metabolic disorders characterised by a deficiency of functional peroxisomes. In a previous study, we showed that oral cholic acid (CA) treatment can suppress bile acid synthesis in ZSD patients and, thereby, decrease plasma levels of toxic C -bile acid intermediates, one of the biochemical abnormalities in these patients. However, no effect on clinically relevant outcome measures could be observed after 9 months of CA treatment. Read More

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http://doi.wiley.com/10.1002/jimd.12042
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http://dx.doi.org/10.1002/jimd.12042DOI Listing
February 2019
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Perceived Quality of Care is associated to disease activity, quality of life, work productivity and gender but not disease phenotype: a prospective study in a high-volume IBD center.

J Crohns Colitis 2019 Feb 21. Epub 2019 Feb 21.

First Department of Medicine, Semmelweis University, Budapest, Hungary.

Background And Aims: Measuring quality of care (QoC) in inflammatory bowel diseases (IBD) has become increasingly important, yet complex assessment of QoC from the patients' perspective is rare. We evaluated perceived QoC using the Quality of Care Through the Patient's Eyes - IBD (QUOTE-IBD) questionnaire, and investigated associations between QoC, disease phenotype, work productivity and health-related quality of life (HRQoL) in a high-volume IBD center.

Methods: Consecutive patients attending McGill University Health Centre (MUHC)-IBD Center completed the QUOTE-IBD, Short Inflammatory Bowel Disease Questionnaire (SIBDQ), IBD-Control and Work Productivity and Activity Impairment (WPAI) questionnaires. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz035DOI Listing
February 2019

Cell Specific Matrix Metalloproteinase-1 Regulates Lung Metastasis Synergistically with Smoke Exposure.

J Cancer Res Forecast 2018 5;1(2). Epub 2018 Nov 5.

Departments of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

MMP1, a matrix metalloproteinase that degrades the extracellular matrix, is produced not only by cancer cells but also synthesized in stromal and inflammatory cells during tumorigenesis, invasion and lung metastasis. However, the function of MMP1 expression from host cells, especially tumor-associated macrophages (TAMs), and cells in the lung parenchyma remains to be elucidated. Here we demonstrate that macrophages co-cultured with tumor cells drastically enhance MMP1 expression, which is further exacerbated upon cigarette smoke exposure. Read More

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November 2018

Gastrointestinal Tract Disorders in Older Age.

Can J Gastroenterol Hepatol 2019 17;2019:6757524. Epub 2019 Jan 17.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Considering an increase in the life expectancy leading to a rise in the elderly population, it is important to recognize the changes that occur along the process of aging. Gastrointestinal (GI) changes in the elderly are common, and despite some GI disorders being more prevalent in the elderly, there is no GI disease that is limited to this age group. While some changes associated with aging GI system are physiologic, others are pathological and particularly more prevalent among those above age 65 years. Read More

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http://dx.doi.org/10.1155/2019/6757524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354172PMC
January 2019

Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations.

Can J Gastroenterol Hepatol 2019 8;2019:4383269. Epub 2019 Jan 8.

The Department of Gastroenterology at Staten Island University Hospital, Northwell Health, USA.

The introduction of Direct Oral Anticoagulants (DOACs) to the pharmaceutical market provided patients and clinicians with novel convenient and safe options of anticoagulation. The use of this class of medications is currently limited to venous thromboembolic therapy and prophylaxis, in addition to stroke prophylaxis in patients with nonvalvular atrial fibrillation. Despite their altered hemostasis, patients with cirrhosis are thought to be in a procoagulant state and thus prone to thrombus formation. Read More

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http://dx.doi.org/10.1155/2019/4383269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354142PMC
January 2019

Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: a multicenter study.

Gastroenterol Rep (Oxf) 2019 Feb 13;7(1):67-73. Epub 2018 Dec 13.

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: This study sought to evaluate the risk factors for the development of colitis-associated neoplasia (CAN) in Chinese patients with inflammatory bowel disease (IBD).

Methods: IBD patients who developed CAN between 1999 and 2016 were identified from eight medical centers. In addition to initial pathology evaluation, a CAN diagnosis was confirmed by two expert pathologists. Read More

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http://dx.doi.org/10.1093/gastro/goy039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375343PMC
February 2019

Evaluating the effectiveness of infliximab on perianal fistulizing Crohn's disease by magnetic resonance imaging.

Gastroenterol Rep (Oxf) 2019 Feb 24;7(1):50-56. Epub 2018 Oct 24.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health; Shanghai Inflammatory Bowel Disease Research Center; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background And Aim: Data on the radiologic evaluation of perianal fistulizing Crohn's disease (PFCD) naïve to anti-tumor necrosis factor therapy are scarce, especially in Asian populations. We assessed the effectiveness of infliximab (IFX) on PFCD and explored predictors of 'deep remission' based on clinical and radiologic assessments.

Methods: Patients with Crohn's disease and active anal fistulas attending our care center for IFX therapy were prospectively enrolled. Read More

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http://dx.doi.org/10.1093/gastro/goy036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375345PMC
February 2019

The physical presence of gallstone modulates cholesterol crystallization pathways of human bile.

Gastroenterol Rep (Oxf) 2019 Feb 5;7(1):32-41. Epub 2018 Dec 5.

Department of Medicine, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Cholesterol crystallization is an essential step toward gallstone formation. Although model bile studies showed that competition occurs between the gallstone surface and the surrounding aqueous phase for cholesterol molecules available for crystallization, this has not been investigated in human bile.

Methods: Fresh gallbladder bile was obtained during laparoscopic cholecystectomy from 13 patients with cholesterol ( = 10) or pigment ( = 3) stones. Read More

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http://dx.doi.org/10.1093/gastro/goy044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375352PMC
February 2019

Acute pancreatitis associated with intravenous administration of propofol: evaluation of causality in a systematic review of the literature.

Gastroenterol Rep (Oxf) 2019 Feb 6;7(1):13-23. Epub 2018 Nov 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Acute pancreatitis (AP) associated with intravenous administration of propofol has been described with unknown causal relation. We therefore assessed this causality in a systematic review. Multiple databases were searched on 16 August 2017; studies were appraised and selected by two reviewers based on a priori criteria. Read More

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http://dx.doi.org/10.1093/gastro/goy038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375349PMC
February 2019

Targeting host-microbe interaction in the mucus layer: a potential treatment option for diseases.

Gastroenterol Rep (Oxf) 2019 Feb 14;7(1):1-2. Epub 2019 Feb 14.

Guangdong Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, P. R. China.

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http://dx.doi.org/10.1093/gastro/goy054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375346PMC
February 2019

Perforation of Heterotopic Gastric Mucosa in ileal duplication in an adult: A case report.

J Surg Case Rep 2019 Feb 12;2019(2):rjz025. Epub 2019 Feb 12.

Department of Surgical Gastroenterology, Royal Care Super Specialty Hospital, Coimbatore, India.

Bowel duplication with heterotopic gastric mucosa (HGM) is a known but uncommon pathology. It usually presents with intussusception or melena in the early years of life. We present a case of ileal duplication with HGM with a rare presentation of bowel perforation and peritonitis in an adult male. Read More

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http://dx.doi.org/10.1093/jscr/rjz025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371854PMC
February 2019

Lymphogranuloma venereum (LGV) proctocolitis mimicking rectal lymphoma.

Radiol Case Rep 2018 Dec 13;13(6):1119-1122. Epub 2018 Sep 13.

Division of Gastroenterology, Department of Medicine, Duke University Medical Center, 2400 Pratt Street, Suite 8007, Durham, NC 27710, USA.

Lymphogranuloma venereum is a sexually transmitted infection caused by serotypes L1-3 of and may present as hemorrhagic proctocolitis. The diagnosis of an active infection is difficult to establish, as confirmatory testing can be unreliable or unavailable. Imaging findings can be nonspecific and mimic malignancy or other chronic infectious and inflammatory disorders. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372233PMC
December 2018

Effectiveness and Tolerability of 3-Day Mebendazole Treatment of Infection in Adults and Children: Two Prospective, Open-Label Phase IV Trials.

Curr Ther Res Clin Exp 2018 30;89:43-47. Epub 2018 Nov 30.

Cuban Institute of Gastroenterology, Havana, Cuba.

Background: is the most common intestinal pathogenic protozoan infection reported in humans. Both in vitro studies and 4 separate, sequential, comparative clinical trials conducted by our group in Cuba demonstrated mebendazole activity against infection in both children and adults.

Objective: The 2 additional, prospective, open-label, Phase IV follow-up studies reported here were performed to further assess the effectiveness and safety profile of mebendazole in the outpatient treatment of infection. Read More

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http://dx.doi.org/10.1016/j.curtheres.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370949PMC
November 2018

Incidence of inflammatory bowel disease by race and ethnicity in a population-based inception cohort from 1970 through 2010.

Therap Adv Gastroenterol 2019 6;12:1756284819827692. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester MN 55905, USA.

Background: Although inflammatory bowel disease (IBD) has been more predominant in white populations, an increasing incidence of IBD in nonwhites has been reported. We sought to evaluate the incidence rates and temporal trends of IBD by race and ethnicity.

Methods: The resources of the Rochester Epidemiologic Project were used to identify 814 county residents newly diagnosed with IBD from 1970 through 2010. Read More

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http://dx.doi.org/10.1177/1756284819827692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376543PMC
February 2019

Novel Pathogenic Variant p.Glu190Lys in a Case of Chronic Pancreatitis.

Front Genet 2019 6;10:46. Epub 2019 Feb 6.

Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States.

Mutations in the (serine protease 1) gene encoding human cationic trypsinogen cause hereditary pancreatitis or may be associated with sporadic chronic pancreatitis. The mutations exert their pathogenic effect either by increasing intra-pancreatic trypsinogen activation (trypsin pathway) or by causing proenzyme misfolding and endoplasmic reticulum stress (misfolding pathway). Here we report a novel heterozygous c. Read More

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http://dx.doi.org/10.3389/fgene.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375306PMC
February 2019

Duodenal Ulceration following Holmium Laser Lithotripsy.

Case Rep Gastroenterol 2019 Jan-Apr;13(1):12-16. Epub 2019 Jan 10.

Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

The epidemiology of peptic ulcer disease (PUD) has changed considerably in the last several decades. Previously a chronic disease characterized by frequent recurrences with a high rate of surgical interventions, it is now largely a self-limited disease that is medically managed. The role of acid suppression was widely recognized as being important in the pathogenesis of PUD in the 19th century, while it was not until the 1980s and 1990s that the importance of infection was identified. Read More

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http://dx.doi.org/10.1159/000485237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381914PMC
January 2019

Successful Endoscopic Management of Double Iatrogenic Perforations Induced by Endoscopic Retrograde Cholangiopancreatography and Computed Tomography-Guided Colon Drainage.

Case Rep Gastroenterol 2019 Jan-Apr;13(1):1-5. Epub 2019 Jan 10.

Division of Hepatology and Gastroenterology, Departments of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Endoscopic retrograde cholangiopancreatography (ERCP) is a high-risk procedure with a significantly high rate of complications, such as pancreatitis, bleeding, perforation, and infection. Pancreatitis is the most common post-ERCP complication with an incidence of approximately 3.5%. Read More

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http://dx.doi.org/10.1159/000495245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381880PMC
January 2019