221,615 results match your criteria Gastroenterology & Hepatology [Journal]


The Lowering of Bilirubin Levels in Full-Term Newborns by the Effect of Combined Massage Therapy and Phototherapy Practice.

Am J Perinatol 2019 Apr 18. Epub 2019 Apr 18.

Faculty of Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective:  Various therapeutic treatments have been prescribed for decreasing the bilirubin level. Massage therapy is one of the neonate treatments for jaundice. The aim of this study is to investigate the effects of combined massage therapy and phototherapy on neonatal jaundice. Read More

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http://dx.doi.org/10.1055/s-0039-1685493DOI Listing

Appendiceal mucocele-A rare case report.

Int J Surg Case Rep 2019 Apr 9;58:21-25. Epub 2019 Apr 9.

Deprtment of General Surgery, JSS Medical College and Hospital, Mysore, India. Electronic address:

Introduction: Appendiceal mucocele is a rare disease and has a clinical picture that resembles acute appendicitis. A correct diagnosis before surgery is very important for the selection of surgical technique(appendicectomy/colectomy)to avoid severe intraoperative and postoperative complications. The work has been reported in line with the SCARE criteria (Agha et al. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.04.008DOI Listing

Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the IκB-α/NF-κB pathway and NLRP3 inflammasome.

Biomed Pharmacother 2019 Apr 15;115:108868. Epub 2019 Apr 15.

Department of Geriatrics, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

The characteristic feature of obesity and insulin resistance is chronic low-grade inflammation. Nod-Like Receptor Pyrin 3 (NLRP3) inflammasome plays a central role in obesity-induced insulin resistance. However, how does Carbenoxolone (CBX) play its role in ameliorating insulin resistance in peripheral tissues of obese mice induced by high-fat diet (HFD) remains unknown. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108868DOI Listing

High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via IL8 and Alterations to the Gut Microbiome.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine, Technical University of Munich, Germany. Electronic address:

Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environmental or dietary factors associated with obesity contribute to progression of BE to EAC in mice. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.04.013DOI Listing
April 2019
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Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK. Electronic address:

Background & Aims: Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optimal. We conducted a meta-analysis of data from individual patients in randomized controlled trials that compared the efficacy of NBI to WLE in detection of adenomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.014DOI Listing
April 2019
1 Read

Reconciliation of Recent Helicobacter pylori Treatment Guidelines in a Time of Increasing Resistance to Antibiotics.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastroenterology, Hepatology and infectious diseases, Otto-von-Guericke University, Magdeburg, Germany, and Ludwig Maximilian University Clinic, Med. Clinic II, Muenchen, Germany.

Increasing resistance to antibiotics, worldwide, has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of Helicobacter pylori infection. We compared the recommendations of these guidelines, reconciled them, and addressed the increasing resistance of H pylori to antibiotic therapy regimens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.011DOI Listing
April 2019
3 Reads

Methylation Tolerance-based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-75012 Paris, France; SIRIC CURAMUS, Equipe labellisée par la Ligue Nationale contre le Cancer. Electronic address:

Background & Aims: Approximately 75% of patients with suspected Lynch syndrome carry variants in MLH1 or MSH2-proteins encoded by these genes are required for DNA mismatch repair (MMR). However, 30% of these are variants of unknown significance (VUS). A assay that measures cell response to the cytotoxic effects of a methylating agent can determine the effects of VUS in MMR genes and identify patients with constitutional mismatch repair-deficiency syndrome. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.071DOI Listing

Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Massachusetts General Hospital, Institute for Technology Assessment, Harvard Medical School, Boston, MA, USA. Electronic address:

Background & Aims: Early liver transplantation (without requiring a minimum period of sobriety) for severe alcohol-associated hepatitis (AH) is controversial-many centers delay eligibility until a specific period of sobriety (such as 6 months) has been achieved. To inform ongoing debate and policy, we modeled long-term outcomes of early vs delayed liver transplantation for patients with AH.

Methods: We developed a mathematical model to simulate early vs delayed liver transplantation for patients with severe AH and different amounts of alcohol use after transplantation: abstinence, slip (alcohol use followed by sobriety), or sustained use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.012DOI Listing
April 2019
1 Read

Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity.

Authors:
Brian C Weiner

Clin Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Clinical Associate Professor, Medicine, Gastroenterology, Hepatology, Nutrition. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.023DOI Listing

Gluten challenge induces skin and small bowel relapse in long-term gluten-free diet-treated dermatitis herpetiformis.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Tampere University Hospital, Tampere, Finland; Celiac Disease Research Center, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address:

Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease causing an itchy, blistering rash. Skin IgA deposits are pathognomonic for DH, and the treatment of choice is a life-long gluten-free diet (GFD). Preliminary evidence suggests that there are DH patients who redevelop gluten tolerance after adherence to a GFD treatment. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1150DOI Listing

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS One 2019 18;14(4):e0215746. Epub 2019 Apr 18.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.

Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcription factor Krüppel-like factor (KLF4) is implicated in a large number of cellular processes, such as proliferation, differentiation, and inflammation in esophageal epithelia. In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215746PLOS

RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis.

PLoS One 2019 18;14(4):e0215132. Epub 2019 Apr 18.

Mass General Hospital for Children and Division of Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, Massachusetts, United States of America.

Background & Aims: The early steps in the pathophysiology of celiac disease (CD) leading to loss of tolerance to gluten are poorly described. Our aim was to use RNA sequencing of duodenal biopsies in patients with active CD, CD in remission, and non-CD controls to gain insight into CD pathophysiology, identify additional genetic signatures linked to CD, and possibly uncover targets for future therapeutic agents.

Methods: We performed whole transcriptome shotgun sequencing of intestinal biopsies in subjects with active and remission CD and non-CD controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215132PLOS

Head-to-head comparison of three stool calprotectin tests for home use.

PLoS One 2019 18;14(4):e0214751. Epub 2019 Apr 18.

Department of Paediatric Gastroenterology Hepatology and Nutrition, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

Objective: Treatment decisions in inflammatory bowel diseases are increasingly based on longitudinal tracking of calprotectin results. Many hospital laboratories measure calprotectin levels in sent-in stool samples with an enzyme-linked immunosorbent assay (ELISA). Several manufacturers introduced a lateral flow-based test with software application that turns a smartphone camera into a reader for quantitative measurements. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214751PLOS

The role of the transition clinic from pediatric to adult inflammatory bowel disease care.

Curr Opin Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: The transition of patients from pediatric to adult centered care represents not only the means to transfer medical care to a group of providers who specialize in adult care but also is part of the process of the transfer of healthcare responsibility from the family to a patient. The intent of this review is to provide a summary of some of the important studies published in the past 2 years that advance this knowledge.

Recent Findings: Progress has been made in the recognition of the process of transition, including developing tools to assess transition readiness, improving routes of communication along with patient education. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000535DOI Listing

Psyche Meets the Gatekeepers: Creating a More Humane Culture for Women in Medicine.

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

S.M. Flaherty is communications director, Center for Celiac Research and Treatment, MassGeneral Hospital for Children, Boston, Massachusetts; ORCID: http://orcid.org/0000-0002-5153-0218. M. Misra is professor of pediatrics, Harvard Medical School, and chief, Division of Pediatric Endocrinology, MassGeneral Hospital for Children, Boston, Massachusetts. S. E. Scott-Vernaglia is assistant professor of pediatrics, Harvard Medical School, and director, Pediatric Residency Program, MassGeneral Hospital for Children, Boston, Massachusetts. E.M. Taveras is professor of pediatrics, Harvard Medical School, and chief, Division of General Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts. E.J. Israel is assistant professor of pediatrics, Harvard Medical School, and associate unit chief, Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, Massachusetts.

In the Greek myth of Psyche and Eros, Psyche must fulfill four seemingly impossible tasks to achieve full consciousness before she can be reunited with her bridegroom, Eros. From early childhood, girls and women can encounter gender stereotyping, sexual harassment and assault, and other gender-related challenges. While both men and women can face mistreatment in medical school, female students experience sexual harassment and sexual assault at higher rates than male students. Read More

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http://dx.doi.org/10.1097/ACM.0000000000002766DOI Listing

Early Gastric Cancer: Current Limitations and What Can Be Done to Address Them.

Am J Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine, Universidad de La Sabana, Bogotá DC, Colombia.

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http://dx.doi.org/10.14309/ajg.0000000000000220DOI Listing
April 2019
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Down syndrome mouse models have an abnormal enteric nervous system.

JCI Insight 2019 Apr 18;5. Epub 2019 Apr 18.

Children with trisomy 21 (Down syndrome [DS]) have a 130-fold increased incidence of Hirschsprung Disease (HSCR), a developmental defect where the enteric nervous system (ENS) is missing from distal bowel (i.e., distal bowel is aganglionic). Read More

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http://dx.doi.org/10.1172/jci.insight.124510DOI Listing

Use of a Coordinated Social Media Strategy to Improve Dissemination of Research and Collect Solutions Related to Workforce Gender Equity.

J Womens Health (Larchmt) 2019 Apr 18. Epub 2019 Apr 18.

10 Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.

To increase awareness, search for solutions, and drive change, disparity-related research needs to be strategically disseminated. This study aimed to quantify whether a social media strategy could: (1) amplify dissemination of gender equity-related articles and (2) collect proposed solutions to gender equity issues. In April 2018, eight published journal articles covering separate gender equity issues were presented in a 1-hour Twitter chat hosted by Physician's Weekly. Read More

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http://dx.doi.org/10.1089/jwh.2018.7515DOI Listing

A novel microRNA signature predicts vascular invasion in hepatocellular carcinoma.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Vascular invasion (VI) in hepatocellular carcinoma (HCC) is an important clinical parameter to predict survival. In this study, we collected microRNA (miRNA) expression data from HCC patients using The Cancer Genome Atlas database and identified a novel miRNA signature associated with VI. First, we categorized HCC patients into groups with or without VI (VI+ and VI-). Read More

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http://dx.doi.org/10.1002/jcp.28690DOI Listing

Hyper-dense fluid on plain computed tomography may reveal a ruptured aneurysm in patients with median arcuate ligament syndrome.

Clin J Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Rupture of abdominal aneurysms associated with median arcuate ligament syndrome (MALS) is a serious condition and requires accurate diagnosis in a clinical setting. We examined three patients with this condition: two women aged 45 and 71 years, and a 61-year-old man. They complained of abdominal pain and had fluid collection around the duodenum. Read More

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http://dx.doi.org/10.1007/s12328-019-00968-wDOI Listing

Impact of Urgent Double-Balloon Enteroscopy on the Short-Term and Long-Term Outcomes in Overt Small Bowel Bleeding.

Dig Dis Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Sendai Kousei Hospital, Sendai, 980-0873, Japan.

Background: Double-balloon enteroscopy (DBE) is a safe and useful procedure for managing small bowel bleeding. However, there are limited studies regarding the preferable timing of DBE and its impact on long-term outcomes.

Aim: We aimed to evaluate the association between the timing of DBE and the long-term outcomes of patients suspected of having overt small bowel bleeding who underwent DBE. Read More

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http://dx.doi.org/10.1007/s10620-019-05627-1DOI Listing

A novel splicing mutation of PTCH1 in a Chinese family with nevoid basal cell carcinoma syndrome.

Med Mol Morphol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the development of multiple jaw keratocysts and basal cell carcinomas (BCC) and accompanied by diverse phenotypes. The establishment of diagnosis lies on the identification of a heterozygous germline pathogenic variant in the patched homolog 1 gene (PTCH1). PTCH1 has alternative splicing and selective initial coding exon, leading to three types of encoding proteins (PTCHL, PTCHM and PTCHS). Read More

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http://dx.doi.org/10.1007/s00795-019-00222-9DOI Listing

Haemostasis treatment using dual red imaging during endoscopic submucosal dissection: a multicentre, open-label, randomised controlled trial.

BMJ Open Gastroenterol 2019 30;6(1):e000275. Epub 2019 Mar 30.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan.

Introduction: Patients scheduled to undergo oesophageal, gastric and colorectal endoscopic submucosal dissection (ESD) are to be investigated to verify the efficacy of dual red imaging (DRI) for establishing haemostasis during ESD.

Methods And Analysis: The trial is designed as a multicentre, open-label randomised, parallel-group, controlled intervention study. Registered patients will be randomly assigned to DRI and white light imaging (WLI) groups. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441255PMC

Erratum: Design and rationale of a randomized-controlled trial of home-delivered meals for the management of symptomatic ascites: the SALTYFOOD trial.

Gastroenterol Rep (Oxf) 2019 Apr 13;7(2):150. Epub 2019 Apr 13.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

[This corrects the article DOI: 10.1093/gastro/goz005.]. Read More

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http://dx.doi.org/10.1093/gastro/goz017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462129PMC

Nivolumab and immune-mediated colitis.

Clin Case Rep 2019 Apr 19;7(4):644-647. Epub 2019 Feb 19.

Department of Pathology Ninewells Hospital and Medical School Dundee UK.

Nivolumab is associated with a number of immune-regulated adverse events, including immune-mediated colitis and may present following the discontinuation of treatment. Current guidance suggests lower doses of methylprednisolone; however, we described faster resolution of the patient's symptoms compared to previous reported cases, using higher dosing, thereby minimizing hospitalization. Read More

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http://dx.doi.org/10.1002/ccr3.2027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452469PMC

Programmable intracellular DNA biocomputing circuits for reliable cell recognitions.

Chem Sci 2019 Mar 15;10(10):2989-2997. Epub 2019 Jan 15.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan , P. R. China . Email:

Dynamic nucleic acid-based biocircuits have spurred substantial research efforts for diagnosis or biomedical applications at the molecular level; nevertheless, it still remains a challenge to design programmable molecular circuit devices for autonomous and accurate diagnosis of low abundance biomolecules in a complex intracellular environment. Herein, a reconfigurable hybridization-based chain reaction is introduced to assemble modular biocomputing circuits that include a general sensing module and a versatile processing module. By modular sensing module design, we realized multiple endogenous miRNA-initiated biocomputing operations, including binary logic gates (OR, AND, INHIBIT and XOR), and more advanced concatenated logic circuits (XOR-AND, XOR-INHIBIT, and XOR-OR) in different living cells. Read More

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http://dx.doi.org/10.1039/c8sc05217dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427941PMC

The gut microflora assay in patients with colorectal cancer: in feces or tissue samples?

Iran J Microbiol 2019 Feb;11(1):1-6

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Gut microbiota is the complex community of microorganisms that live in the digestive tracts of humans and other animals, including insects. The relationship between gut microbiota and human health is mutualistic and altered bacterial compositions in fecal and mucosal specimens of colon in patients with cancer compared to healthy subjects were observed. Thereby, studying the gut microbiota, their interactions with the host and their alterations in colorectal cancer (CRC) patients could be helpful to diagnose and treat the disease in earlier stages. Read More

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February 2019
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Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression.

Cancer Cell Int 2019 5;19:87. Epub 2019 Apr 5.

16Department of Pharmacy, China Medical University, Taichung, 404 Taiwan.

Background: To determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.

Methods: We systematically evaluated 79 germline variants in nine circadian pathway genes in a cohort of 458 patients with localized prostate cancer as the discovery phase. We then replicated the significant findings in another cohort of 324 men with more advanced disease. Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0811-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451277PMC
April 2019
1 Read

[Comparison of the minimally invasive treatments of laparoscopic and endosopic for common bile duct stones after gastrojejunostomy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):345-348

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To explore the feasibility and to compare the merits and demerits of laparoscopic and endoscopic approach in removing common bile duct stones in patients with gastrojejunostomy after gastrectomy.

Methods: Between January 2012 and December 2016, 25 patients with common bile duct stones after gastrojejunostomy received laparoscopic or endoscopic treatment in our centers. They were divided into laparoscopic group and endoscopic group based on treatment approaches for common bile duct stones, including 15 patients in laparoscopic group and 10 in endoscopic group. Read More

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[Characteristics analysis of early gastric cancer under white light endoscopy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):302-306

Department of gastroenterology,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate endoscopic features of early gastric cancer and clinical features of the patients, which may be helpful to provide reasonable suggestions for physicians to diagnose early gastric cancer during preliminary screening of white light gastroscopy.

Methods: A total of 271 patients who received endoscopic submucosal dissection or surgical operation to confirm early gastric cancer in Peking University Third Hospital from Apr. 2009 to Jun. Read More

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Loss of PKM2 in Lgr5 intestinal stem cells promotes colitis-associated colorectal cancer.

Sci Rep 2019 Apr 17;9(1):6212. Epub 2019 Apr 17.

Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Republic of Korea.

The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated the effectiveness of conditionally ablating PKM2 in Lgr5 intestinal stem cells (ISC) using a mouse model of colitis-associated CRC (AOM plus DSS). Read More

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http://dx.doi.org/10.1038/s41598-019-42707-8DOI Listing

Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells.

Sci Rep 2019 Apr 17;9(1):6400. Epub 2019 Apr 17.

Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42588-xDOI Listing

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

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http://dx.doi.org/10.1038/s41598-019-41147-8DOI Listing

Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease.

Intest Res 2019 Apr 18. Epub 2019 Apr 18.

Departments of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Background/aims: The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative histological classification system for the assessment of intestinal mucosal biopsies.

Methods: We performed a computer-assisted quantitative histological assessment of digital images of duodenal biopsies from 137 controls and 124 patients with celiac disease (CeD) (derivation cohort). Read More

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http://dx.doi.org/10.5217/ir.2018.00167DOI Listing

Acute-onset Autoimmune Hepatitis in a Patient with Selective Immunoglobulin M Deficiency.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.

Selective immunoglobulin M deficiency (SIGMD) is an uncommon primary immunodeficiency disorder. We herein report an SIGMD patient with autoimmune hepatitis. A 21-year-old Japanese man was transferred to our hospital because of acute liver dysfunction. Read More

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http://dx.doi.org/10.2169/internalmedicine.2607-18DOI Listing

Safety and Efficacy of Endoscopic Removal of Common Bile Duct Stones in Elderly Patients ≥90 Years of Age.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Kumamoto Chuo Hospital, Japan.

Objective We examined the safety and efficacy of endoscopic stone removal for choledocholithiasis in elderly patients ≥90 years of age with native papilla and compared the outcomes with those in patients 75-89 years of age. Methods This multicenter retrospective study included 569 patients 75-89 years of age and 126 patients ≥90 years of age who had native papilla and underwent therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis at 3 institutions in Japan between April 2012 and March 2018. The main outcomes assessed were the incidence of post-ERCP complications during hospitalization and outcomes of ERCP in patients ≥90 years of age. Read More

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http://dx.doi.org/10.2169/internalmedicine.2546-18DOI Listing

Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-Associated Inflammatory Bowel Disease.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Autoimmune diseases including inflammatory bowel disease (IBD) occur in association with myelodysplastic syndrome (MDS). MDS-associated IBD frequently demonstrates a complicated course. We herein report the first case with MDS-associated IBD that was successfully treated with ustekinumab (UST), an anti-interleukin (IL) 12/23p40 monoclonal antibody. Read More

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http://dx.doi.org/10.2169/internalmedicine.2495-18DOI Listing

Atypical Endoscopic Findings of Rectal Perineurioma.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology, NTT Medical Center, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2316-18DOI Listing

Endoscopic Features and Diagnostic Procedures of Eosinophilic Gastroenteritis.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Saitama Medical University, Japan.

No specific endoscopic features for eosinophilic gastroenteritis (EGE) have been reported previously. This study therefore evaluated the endoscopic findings of six patients with EGE. The diagnosis was confirmed based on gastrointestinal symptoms, pathological findings on biopsy, and the absence of other diseases. Read More

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http://dx.doi.org/10.2169/internalmedicine.2298-18DOI Listing

Clinical Safety and Efficacy of Secondary Prophylactic Pegylated G-CSF in Advanced Pancreatic Cancer Patients Treated with mFOLFIRINOX: A Single-center Retrospective Study.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Objective Although modified FOLFIRINOX (mFOLFIRINOX, mFFX) is widely used for patients with advanced pancreatic ductal adenocarcinoma (PDAC), maintenance of the standard dose intensity is often difficult due to the high incidence of neutropenic events. Pegylated granulocyte colony-stimulating factor (G-CSF) (Peg G) is a long-lasting G-CSF agent that is applicable for prophylaxis against neutropenic complications. The aim of this study was to assess the clinical safety and efficacy of mFFX combined with secondary prophylaxis using Peg G in advanced PDAC patients. Read More

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http://dx.doi.org/10.2169/internalmedicine.2234-18DOI Listing

A Case of Hemorrhagic Gastric Metastasis from Hepatocellular Carcinoma Successfully Treated Using Coil Embolization of the Left Gastric Artery.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan.

A 62-year-old man initially underwent transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma (HCC). One year after the initial treatment, he developed anemia. Upper gastrointestinal endoscopy revealed irregularly elevated tumors in the lower anterior gastric body, which were diagnosed to be metastasis from HCC. Read More

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http://dx.doi.org/10.2169/internalmedicine.2172-18DOI Listing

The Usefulness of Video Capsule Endoscopy in Evaluating Gastrointestinal Manifestations of Immunoglobulin A Vasculitis.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan.

Objective Immunoglobulin (Ig) A vasculitis (IgAV) is a systemic vasculitis characterized by purpura and gastrointestinal involvement showing abdominal pain that usually occurs after the emergence of purpura. Criteria for evaluating gastrointestinal manifestations of IgAV are unavailable at present, so we conducted a study to investigate the usefulness of video capsule endoscopy (VCE) for detecting gastrointestinal manifestations of IgAV. Methods The clinical data of 10 patients who underwent VCE for IgAV at our hospital from 2012 to 2017 were collected. Read More

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http://dx.doi.org/10.2169/internalmedicine.2097-18DOI Listing

Endoscopic Ultrasound-guided Drainage of a Mediastinal Abscess Caused by an Ingested Fish Bone.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.

Cases of foreign body ingestion are encountered relatively often in clinical settings; however, serious complications are rare. In such cases, mediastinal abscess due to esophageal perforation can become a life-threatening complication. Although highly invasive, surgery is often used as the first-line treatment. Read More

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http://dx.doi.org/10.2169/internalmedicine.1992-18DOI Listing

Temperature-responsive biometamaterials for gastrointestinal applications.

Sci Transl Med 2019 Apr;11(488)

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm water ingestion) and extra-esophageal (protected from ingestion of warm liquids and actuatable by endoscopically administered warm fluids). Inspired by a blooming flower, we developed a capsule-sized esophageal system that deploys using elastomeric elements and then recovers its original shape in response to thermal triggering of shape-memory nitinol springs by ingestion of warm water. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau8581DOI Listing

Biliary dilatation in a 67-year-old woman: seeing is believing.

Gut 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-318200
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http://dx.doi.org/10.1136/gutjnl-2018-318200DOI Listing
April 2019
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Concerns regarding the recommendations of the British Society of Gastroenterology's lower GI bleeding guidelines.

Gut 2019 Apr 17. Epub 2019 Apr 17.

Gastroenterology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

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http://dx.doi.org/10.1136/gutjnl-2019-318582DOI Listing

Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis.

Gut 2019 Apr 17. Epub 2019 Apr 17.

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

Objective: Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-318160DOI Listing

A case of ectopic pancreas in the ileum presenting as obscure gastrointestinal bleeding and abdominal pain.

BMC Gastroenterol 2019 Apr 17;19(1):57. Epub 2019 Apr 17.

Clinic of Gastroenterology, Nephrourology and Surgery, Vilnius University, Santariskiu street 2, 08406, Vilnius, LT, Lithuania.

Background: Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in the ileum is a rare and often an incidental finding. We report a case of ectopic pancreas in the ileum causing obscure gastrointestinal bleeding and episodes of abdominal pain. Read More

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http://dx.doi.org/10.1186/s12876-019-0971-7DOI Listing

Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations.

Pharmaceutics 2019 Apr 16;11(4). Epub 2019 Apr 16.

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

In ulcerative colitis (UC), the inflammation is localized in the colon, and one of the successful strategies for colon-targeting drug delivery is the prodrug approach. In this work, we present a novel phospholipid (PL)-based prodrug approach, as a tool for colonic drug targeting in UC. We aim to use the phospholipase A (PLA), an enzyme that is overexpressed in the inflamed colonic tissues of UC patients, as the PL-prodrug activating enzyme, to accomplish the liberation of the parent drug from the prodrug complex at the specific diseased tissue(s). Read More

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http://dx.doi.org/10.3390/pharmaceutics11040186DOI Listing