32,294 results match your criteria Gastroenterology[Journal]


Circulating Epithelial Cells in Patients with Liver Disease.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatric Surgery, Children's Hospital of Fudan University and Shanghai Key Laboratory of Birth Defect Shanghai 201102, P.R. China.

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http://dx.doi.org/10.1053/j.gastro.2018.10.062DOI Listing
February 2019

Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and Fondazione Luigi Villa, Milano, Italy.

Portal vein thrombosis unrelated to solid malignancy is common in patients with cirrhosis but less frequently observed in patients without cirrhosis. Prompt diagnosis and management of acute symptomatic portal vein thrombosis are essential. Failure to detect and treat thromboses can result in mesenteric ischemia, chronic cavernous transformation, and complications of portal hypertension. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.265DOI Listing
February 2019

Predict, Resect, Identify and Discard Strategy with Full-field Optical Coherence Tomography: Two Steps Forward, One Step Back.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.01.264DOI Listing
February 2019

Reply to "Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease": Implications for transplant chimerism.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Erasmus MC, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.12.047DOI Listing
February 2019

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Monash Institute of Pharmaceutical Sciences, and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia; Columbia University College of Physicians and Surgeons, Columbia University in the City of New York, 21 Audubon Avenue, Rm 209, New York City, NY 10032, USA. Electronic address:

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.266DOI Listing
February 2019

Validation of Baveno VI Criteria for Screening and Surveillance of Esophageal Varices in Patients With Compensated Cirrhosis and a Sustained Response to Antiviral Therapy.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

AP-HP, Hôpital Jean Verdier, Service d'Hépatologie, Bondy, Université Paris 13, Bobigny et INSERM U1162, Université Paris 5, Paris.

Background & Aims: Management of patients with cirrhosis includes endoscopic screening and surveillance to detect esophageal varices (EV) and prevent bleeding. However, the Baveno VI guidelines recommend avoiding endoscopies for patients with liver stiffness measurements below 20 kPa and platelet counts above 150,000 (favorable Baveno VI status) and endoscopic assessment of patients with higher levels of liver stiffness and platelet counts (unfavorable Baveno VI status). We aimed to validate the Baveno VI guidelines, evaluating outcomes of patients in the ANRS-CO12 CirVir cohort with compensated cirrhosis associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, with or without a sustained response to antiviral therapy. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.11.053DOI Listing
February 2019

Organ Failure due to Systemic Injury in Acute Pancreatitis.

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Mayo Clinic, Scottsdale, Arizona, USA. Electronic address:

Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure which is seen in approximately 20% of all cases of acute pancreatitis and defines 'severe acute pancreatitis'. Organ failure typically develops early in the course of acute pancreatitis, but may also develop later due to infected pancreatic necrosis induced sepsis. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.12.041DOI Listing
February 2019

The role of the microbiome in immunologic development and its implication for pancreatic cancer immunotherapy.

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL. Electronic address:

Our understanding of the microbiome and its role in immunity, cancer initiation, and cancer progression has evolved significantly over the past century. The "germ theory of cancer" was first proposed in the early 20 century, and shortly thereafter the bacterium Helicobacter pylori and later, Fusobacterium nucleatum were implicated in the development of gastric and colorectal cancers respectively. However, with the development of reliable mouse models and affordable sequencing technologies, the most fascinating aspect of the microbiome-cancer relationship, where microbes undermine cancer immune surveillance and indirectly promote oncogenesis, has only recently been described. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.12.045DOI Listing
February 2019

Systems Biology Analyses Reveal Hyperactivation of Transforming Growth Factor beta and JNK Signaling pathways in Esophageal Cancer.

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Division of General Medical Sciences-Oncology. Electronic address:

Background & Aims: Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might be targeted to slow tumor growth or progression.

Methods: We collected 397 biopsy specimens from patients with EAC and non-malignant Barrett's esophagus (BE), with or without dysplasia. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.263DOI Listing
February 2019
16.716 Impact Factor

Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level.

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Background & Aims: Hepatitis D virus (HDV) super-infection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8+ T cells are thought to control the virus, little is known about which HDV epitopes are targeted by virus-specific CD8+ T cells or why these cells ultimately fail to control the infection. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.003DOI Listing
February 2019

Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.

BMC Gastroenterol 2019 Feb 14;19(1):31. Epub 2019 Feb 14.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.

Methods: Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Read More

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http://dx.doi.org/10.1186/s12876-019-0947-7DOI Listing
February 2019

Inflammatory bowel disease patient perceptions of diagnostic and monitoring tests and procedures.

BMC Gastroenterol 2019 Feb 13;19(1):30. Epub 2019 Feb 13.

Department of Medicine, Université de Montréal & Montreal Heart Institute, Montreal, H1T 1C8, Canada.

Background: Inflammatory Bowel Disease (IBD) with its high incidence and prevalence rates in Canada generates a heavy burden of tests and procedures. The purpose of this study is to gain a better understanding of the transfer of information from physician to patient, as well as the patient understanding and perceptions about the tests and procedures that are ordered to them in the context of IBD diagnosis and monitoring.

Methods: An online questionnaire was completed by 210 IBD patients in Canada. Read More

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http://dx.doi.org/10.1186/s12876-019-0946-8DOI Listing
February 2019

Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial.

BMC Gastroenterol 2019 Feb 12;19(1):29. Epub 2019 Feb 12.

Department of Medicine, National University of Ireland, University College Cork, Cork University Hospital, Wilton, T12 DC4A, Cork, Ireland.

Background: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.

Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Read More

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http://dx.doi.org/10.1186/s12876-019-0952-xDOI Listing
February 2019

A comparison of the diagnosis of gastroparesis in 4 h pediatric gastric emptying studies versus 2 h studies.

BMC Gastroenterol 2019 Feb 11;19(1):26. Epub 2019 Feb 11.

Division of Gastroenterolgy, Children's Mercy Kansas City, 2401 Gillham Rd, Kansas City, MO, 64108, USA.

Background: In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, some cost savings might be achieved if symptoms could be utilized to predict patients with gastroparesis. The aims of the current study were to confirm the sensitivity of a 4 h study in the pediatric population and to assess whether the severity of symptoms were predictive of delayed gastric emptying. Read More

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http://dx.doi.org/10.1186/s12876-019-0948-6DOI Listing
February 2019

Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis.

BMC Gastroenterol 2019 Feb 11;19(1):27. Epub 2019 Feb 11.

Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Virginia, USA.

Background: Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnosis and determine whether quantification of staining by computer assisted morphometry (CAM) can be used to assess severity of ballooning degeneration. Read More

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http://dx.doi.org/10.1186/s12876-019-0951-yDOI Listing
February 2019
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Plasma levels of TNF-α, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD).

BMC Gastroenterol 2019 Feb 11;19(1):28. Epub 2019 Feb 11.

University of South Florida, Division of Gastroenterology, Florida, USA.

An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to achalasia or occurs with other diseases involving the esophagus. The primary aim of our study was to compare the differences in plasma immunological profiles (TNF- α receptor, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23) of patients with achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD). Read More

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http://dx.doi.org/10.1186/s12876-019-0937-9DOI Listing
February 2019
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Efficacy of Per-oral Methylene Blue Formulation for Screening Colonoscopy.

Gastroenterology 2019 Feb 8. Epub 2019 Feb 8.

Ospedale Nuovo Regina, Margherita, Gastroenterology Unit, Roma, Italy.

Background & Aims: Topically applied methylene blue dye chromoendoscopy is effective in improving detection of colorectal neoplasia. When combined with a pH- and time-dependent multi-matrix structure, a per-oral methylene blue formulation (MB-MMX) can be delivered directly to the colorectal mucosa.

Methods: We performed a phase 3 study of 1205 patients scheduled for colorectal cancer screening or surveillance colonoscopies (50-75 years old) at 20 sites in Europe and the United states, from December 2013 through October 2016. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.001DOI Listing
February 2019

Postprandial Nutrient Handling and Gastrointestinal Secretion of Hormones After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.

Gastroenterology 2019 Feb 8. Epub 2019 Feb 8.

Dept. of Endocrinology, Copenhagen University Hospital Hvidovre, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark; Dept. of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address:

Background & Aims: Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) induce substantial weight loss and improve glycemic control in patients with type 2 diabetes, but it is not clear whether these occur via the same mechanism. We compared absorption rates of glucose and protein, as well as profiles of gastro-entero-pancreatic hormones, in patients who had undergone SG or RYGB vs controls.

Methods: We performed a cross-sectional study of 12 patients who had undergone sleeve gastrectomy, 12 patients who had undergone RYGB, and 12 individuals who had undergone neither surgery (controls), all in Denmark. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.262DOI Listing
February 2019
1 Read

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.

Gastroenterology 2019 Feb 8. Epub 2019 Feb 8.

Shanghai Liver Diseases Research Center, 85th Hospital of Nanjing Military Command. Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.

Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers in mainland China. We collected demographic, medical history, treatment, laboratory, disease severity, and mortality data from all patients. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.002DOI Listing
February 2019
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Biomarkers associated with response to regorafenib in patients with hepatocellular carcinoma.

Gastroenterology 2019 Feb 6. Epub 2019 Feb 6.

BCLC Group, Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain.

Background & Aims: In a phase 3 trial (RESORCE), regorafenib increased overall survival compared with placebo in patients with hepatocellular carcinoma (HCC) previously treated with sorafenib. In an exploratory study, we analyzed plasma and tumor samples from study participants to identify genetic, microRNA (miRNA), and protein biomarkers associated with response to regorafenib.

Methods: We obtained archived tumor tissues and baseline plasma samples from patients with HCC given regorafenib in the RESORCE trial. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.261DOI Listing
February 2019

Magnitude, Risk Factors, and Factors Associated With Adenoma Miss Rate of Tandem Colonoscopy: A Systematic Review and Meta-analysis.

Gastroenterology 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China; Digestive Endoscopy Center, Changhai Hospital, Naval/Second Military Medical University, Shanghai, China; National Clinical Research Center for Digestive Diseases, Shanghai, China.

Background & Aims: We performed a systematic review and meta-analysis to comprehensively estimate the adenoma miss rate (AMR) and advanced AMR (AAMR) and explore associated factors.

Methods: We searched the PubMed, Web of Science, and Ovid EMBASE databases for studies published through April 2018 on tandem colonoscopies, with AMR and AAMR as the primary outcomes. We performed meta-regression analyses to identify risk factors and factors associated with outcome. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.260DOI Listing
February 2019

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.

BMC Gastroenterol 2019 Feb 8;19(1):25. Epub 2019 Feb 8.

Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts and graft loss. Some reports have found that molecular-hydrogen showed antioxidant and anti-inflammatory effects in preventing IRI in some non-hepatic transplant models. Read More

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http://dx.doi.org/10.1186/s12876-019-0939-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368804PMC
February 2019

Clinicopathologic characteristics of early gastric cancer according to specific intragastric location.

BMC Gastroenterol 2019 Feb 8;19(1):24. Epub 2019 Feb 8.

Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea.

Background: Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no attempt to visualize the intra-gastric distribution of EGCs using a merged tumor map.

Methods: We investigated the anatomic distribution of 644 cases of EGCs and analyzed the correlation between clinicopathologic findings and location by dividing areas of the stomach vertically and transversely. Read More

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http://dx.doi.org/10.1186/s12876-019-0949-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368692PMC
February 2019

Early Detection of Pancreatic Cancer: Opportunities and Challenges.

Gastroenterology 2019 Feb 2. Epub 2019 Feb 2.

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas; Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas.

The vast majority of patients with pancreatic ductal adenocarcinoma (PDAC) presents with symptomatic, surgically unresectable disease. While the goal of early detection of PDAC is laudable, and likely to result in significant improvement in overall survival, the relatively low prevalence of PDAC renders general population screening infeasible. The challenges of early detection include identification of at-risk individuals in the general population who would benefit from longitudinal surveillance programs, and appropriate biomarker and imaging-based modalities utilized for PDAC surveillance in such cohorts. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.259DOI Listing
February 2019
1 Read

Fibroblasts in Pancreatic Ductal Adenocarcinoma: biological mechanisms and therapeutic targets.

Gastroenterology 2019 Feb 2. Epub 2019 Feb 2.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA, 98195. Electronic address:

The desmoplastic reaction of pancreas cancer may begin as a wound healing response to the nascent neoplasm, but it soon creates an insidious shelter that can sustain the growing tumor and rebuff therapy. Among the many cell types subverted by transformed epithelial cells, fibroblasts are recruited and activated to lay a foundation of extracellular matrix proteins and glycosaminoglycans that alter tumor biophysics and signaling. Their near-universal presence in pancreas cancer and ostensible support of disease progression make fibroblasts attractive therapeutic targets. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.12.044DOI Listing
February 2019
1 Read

The frequency, clinical course, and health related quality of life in adults with Gilbert's syndrome: a longitudinal study.

BMC Gastroenterol 2019 Feb 4;19(1):22. Epub 2019 Feb 4.

Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt.

Background: Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, genetic profile and health related quality of life in Egyptian adults.

Methods: An initial cross-sectional study was conducted to assess the frequency of Gilbert syndrome among Egyptian adults. Read More

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http://dx.doi.org/10.1186/s12876-019-0931-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360704PMC
February 2019
2 Reads

Endoscopic injection sclerotherapy versus N-Butyl-2 Cyanoacrylate injection in the management of actively bleeding esophageal varices: a randomized controlled trial.

BMC Gastroenterol 2019 Feb 4;19(1):23. Epub 2019 Feb 4.

Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may necessitate an alternative therapy for this group of patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0940-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362581PMC
February 2019
2.365 Impact Factor

Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma.

BMC Gastroenterol 2019 Feb 4;19(1):21. Epub 2019 Feb 4.

Institute of Pathology, University of Cologne, Cologne, Germany.

Background: Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized treatment options in small bowel carcinoma. Read More

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http://dx.doi.org/10.1186/s12876-019-0942-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360678PMC
February 2019
1 Read

Signaling Networks that Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression and Metastasis.

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Department of Surgery, University of Miami, Miami, FL, USA; Sylvester Cancer Center, University of Miami, Miami, FL, USA. Electronic address:

Pancreatic ductal adenocarcinoma is one of the deadliest cancers, with its incidence on the rise. Major challenges in overcoming the poor prognosis presented by this disease lies in late detection and the aggressive biology of the disease. Intra-tumoral heterogeneity, presence of a robust, reactive and desmoplastic stroma as well as the crosstalk between the different tumor components indicate that a complete understanding of the pancreatic tumor biology is required to better understand the therapeutic challenges posed by this disease. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.12.042DOI Listing
February 2019

A Fatal Cause of Small Bowel Obstruction.

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, SUNY Downstate Medical Center, Brooklyn, New York.

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http://dx.doi.org/10.1053/j.gastro.2019.01.258DOI Listing
February 2019
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Prevalence of Germline Mutations Associated with Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms.

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

Background & Aims: Many patients with pancreatic adenocarcinoma (PDAC) carry germline mutations associated with increased risk of cancer. It is not clear whether patients with intraductal papillary mucinous neoplasms (IPMNs), which are precursors to some pancreatic cancers, also carry these mutations. We assessed the prevalence of germline mutations associated with cancer risk in patients with histologically confirmed IPMN. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.254DOI Listing
February 2019

"Small bowel necrosis following colonoscopy."

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA.

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http://dx.doi.org/10.1053/j.gastro.2019.01.257DOI Listing
February 2019

You Just got Burned! What is wrong with this gastric pouch?

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Division of Gastroenterology, Hepatology and Endoscopy - Brigham and Women's Hospital - Harvard Medical School, MA-USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193035
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http://dx.doi.org/10.1053/j.gastro.2019.01.255DOI Listing
February 2019
1 Read

A rare cause of fever and abdominal pain.

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Departement of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1053/j.gastro.2019.01.256DOI Listing
February 2019

Pancreatitis in Children.

Gastroenterology 2019 Feb 1. Epub 2019 Feb 1.

Children's Hospital of Pittsburgh, Pittsburgh, PA.

Acute, acute recurrent and chronic pancreatitis have been increasingly diagnosed in children within the last two decades. The risk factors in the pediatric age group are broad and they appear to be strikingly different compared to the adult cohort. However, the disease burden and impact on quality of life are surprisingly similar between children and adults. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.12.043DOI Listing
February 2019
1 Read

Use of Expression Profiles of HBV DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

Gastroenterology 2019 Jan 31. Epub 2019 Jan 31.

Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; Singapore Immunology Network, Agency for Science and Technology (A*STAR), Singapore. Electronic address:

Background & Aims: Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV DNA fragments encode epitopes that are recognized by T cells and whether their presence in HCCs can be used to select HBV-specific T-cell receptors (TCRs) for immunotherapy. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.251DOI Listing
January 2019
2 Reads
16.716 Impact Factor

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

Gastroenterology 2019 Jan 31. Epub 2019 Jan 31.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background & Aims: Inhibitors of MET have not produced satisfactory outcomes in trials of patients with liver cancer. We investigated the mechanisms of liver tumor resistance to MET inhibitors in mice.

Methods: We tested the effects of the MET inhibitors tivantinib and capmatinib in the mouse HCC cell line HCA-1, and in immune-competent and immunodeficient mice with subcutaneous tumors grown from this cell line. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193034
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http://dx.doi.org/10.1053/j.gastro.2019.01.252DOI Listing
January 2019
2 Reads

Effects of Promotility Agents on Gastric Emptying and Symptoms: a Systematic Review and Meta-Analysis.

Gastroenterology 2019 Jan 31. Epub 2019 Jan 31.

Evidence Based Practice Center, Mayo Clinic, Rochester, MN.

Background & Aims: Studies have reported a lack of association between improvements in gastric emptying (GE) and upper gastrointestinal (UGI) symptoms with promotility drugs. However, GE test methods were suboptimal in some studies. We assessed improvements in GE and UGI symptoms in patients given promotility agents in studies with optimal or moderate test methods (scintigraphy or breath test, solid meal, >2 hr duration) compared to studies with suboptimal GE test methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193034
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http://dx.doi.org/10.1053/j.gastro.2019.01.249DOI Listing
January 2019
2 Reads

Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.

Gastroenterology 2019 Jan 31. Epub 2019 Jan 31.

State Key Laboratory of Oncology in South China, Cancer Center, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China; Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address:

Background & Aims: Little is known about the composition and generation of plasma cell subsets in patients with hepatocellular carcinoma (HCC) and how these associate with outcome. We investigated whether (or how) plasma cells differentiate and function in patients with HCC and mice with liver tumors.

Methods: We analyzed subset composition and distribution plasma cells in HCC samples from 342 patients who underwent curative resection at the Cancer Center of Sun Yat-sen University in China; samples of non-tumor liver tissue were used as controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193034
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http://dx.doi.org/10.1053/j.gastro.2019.01.250DOI Listing
January 2019
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Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders.

Gastroenterology 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center. Electronic address:

Background: Diagnostic testing for chronic esophageal disorders rely on histopathology analysis of biopsies or uncomfortable transnasal catheters or wireless pH monitoring, which capture abnormal intraluminal refluxate. We therefore developed a balloon mucosal impedance (MI) catheter system that instantly detects changes in esophageal mucosal integrity during endoscopy over a long segment of the esophagus. We performed a prospective study to evaluate the ability of a balloon-incorporated MI catheter to detect and evaluate esophageal disorders, including gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193035
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http://dx.doi.org/10.1053/j.gastro.2019.01.253DOI Listing
January 2019
4 Reads

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T and CD4+ T cell-Dependent Control of Senescence.

Gastroenterology 2019 Jan 30. Epub 2019 Jan 30.

Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany; Department of Hepatology/Gastroenterology, Charité University Medical Center, Berlin, Germany. Electronic address:

Background & Aims: Inflammation in the liver provokes fibrosis but inflammation is also important for tumor surveillance. Inhibitors of chemokine pathways, such as CXCL16 and CXCR6 regulation of lymphocyte trafficking, are being tested as anti-fibrotic agents, but their effects on development of hepatocellular carcinoma (HCC) are unclear. We assessed the roles of CXCR6-dependent immune mechanisms in hepatocarcinogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193034
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http://dx.doi.org/10.1053/j.gastro.2019.01.247DOI Listing
January 2019
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Correction of Defective T-regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor Alpha.

Gastroenterology 2019 Jan 17. Epub 2019 Jan 17.

School of Immunology and Microbial Sciences, King's College London; National Institute for Health Research Biomedical Research Centre, Guy's and St Thomas' NHS Trust and King's College London. Electronic address:

Background & Aims: Crohn's disease (CD) is characterized by an imbalance of effector and regulatory T cells in the intestinal mucosa. The efficacy of anti-adhesion therapies led us to investigate whether impaired trafficking of T-regulatory (Treg) cells contributes to the pathogenesis of CD. We also investigated whether proper function could be restored to Treg cells by ex vivo expansion in the presence of factors that activate their regulatory activities. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.025DOI Listing
January 2019
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Elevated D-dimer is associated with increased 28-day mortality in acute-on-chronic liver failure in China: a retrospective study.

BMC Gastroenterol 2019 Jan 31;19(1):20. Epub 2019 Jan 31.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is associated with poorer prognosis. We aim to determine the potential association of D-dimer with the 28-day mortality in ACLF patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0941-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357416PMC
January 2019
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High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.

BMC Gastroenterol 2019 Jan 29;19(1):19. Epub 2019 Jan 29.

Centre for Psychology and Sports Science, University of Hertfordshire, Life and Medical Sciences, CP Snow Building, College Lane, Hatfield, AL10 9AB, UK.

Background: This study assessed the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with Crohn's disease (CD).

Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Read More

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http://dx.doi.org/10.1186/s12876-019-0936-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352351PMC
January 2019

The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study.

BMC Gastroenterol 2019 Jan 28;19(1):18. Epub 2019 Jan 28.

Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London, UK.

Background: Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

Methods: We conducted a population-based study of ALF patients hospitalized between 2009 and 2013 from the Thai Nationwide Hospital Admission database, which comprises 76% of all admissions from 858 hospitals across 77 provinces in Thailand. Read More

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http://dx.doi.org/10.1186/s12876-019-0935-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348628PMC
January 2019
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2.365 Impact Factor

PRC2 proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Gene Expression at Promoter Regions in Euchromatin in Mice.

Gastroenterology 2019 Jan 25. Epub 2019 Jan 25.

Institute for Regenerative Medicine; Penn Epigenetics Institute; Dept. Cell and Developmental Biology; Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, 3400 Civic Center Blvd, Bldg. 421, Philadelphia, PA 19104-5157, USA. Electronic address:

Background & Aims: Little is known about mechanisms of postnatal hepatocyte maturation or chromatin regulation of genes that control fibrogenesis. We investigated transcription of genes that regulate fibrosis and the effects of chromatin compaction and the polycomb repressive complex 2 (PRC2) in postnatal hepatocytes of mice, focusing on the roles of the histone methyltransferases EZH1 and EZH2.

Methods: Hepatocytes were isolated from C57BL/6J and C3H mice, as well as mice with liver-specific disruption of Ezh1 and/or Ezh2, at postnatal day 14 (P14) and 2 months after birth (M2). Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.041DOI Listing
January 2019

Effects of Oral Anticoagulants and Aspirin on Performance of Fecal Immunochemical Tests in Colorectal Cancer Screening.

Gastroenterology 2019 Jan 25. Epub 2019 Jan 25.

Head, Department of Bowel Cancer Screening, Cancer Registry of Norway, Oslo, Norway; Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; Department of Medicine, Sorlandet Hospital Kristiansand, Kristiansand, Norway.

Background & Aims: The fecal immunochemical test (FIT) is the tool most frequently used for colorectal cancer (CRC) screening worldwide. It is unclear how the use of aspirin and oral anticoagulants in the screening population affect the diagnostic performance of FIT.

Methods: We performed a cross-sectional study in an ongoing CRC screening trial in Norway. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.040DOI Listing
January 2019
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Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Non-alcoholic Fatty Liver Disease.

Gastroenterology 2019 Jan 25. Epub 2019 Jan 25.

National Institute for Health Research Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham; Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham. Electronic address:

Background & Aims: We estimated the accuracy of FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP) and liver stiffness measurements (LSMs) in assessing steatosis and fibrosis in patients with suspected NAFLD.

Methods: We collected data from 450 consecutive adults who underwent liver biopsy analysis for suspected NAFLD at 7 centers in the United Kingdom from March 2014 through January 2017. FibroScan examinations with M or XL probe were completed within the 2 weeks of the biopsy analysis (404 had a valid examination). Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.042DOI Listing
January 2019