32,134 results match your criteria Gastroenterology[Journal]


Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Gastroenterology 2018 Dec 11. Epub 2018 Dec 11.

Molecular & Integrative Physiology, University of Michigan School of Public Health, Ann Arbor MI; Internal Medicine Division of Gastroenterology, University of Michigan School of Public Health, Ann Arbor MI; Rogel Cancer Center. University of Michigan Medical School, Ann Arbor MI. Electronic address:

Background & Aims: Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis.

Methods: Colitis-associated colon cancer was induced mice with conditional deletion of neutrophils (LysMCre;Mcl1) and wild-type littermates (LysMCre;Mcl1, control mice) by administration of azoxythmethane and/or dextran sulfate sodium. Read More

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December 2018

Treatment of Active Crohn's Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition.

Gastroenterology 2018 Dec 11. Epub 2018 Dec 11.

Human Nutrition, School of Medicine, Dentistry & Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

Background & Aims: Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn's disease (CD), but its acceptability is limited. There is a need for novel dietary treatments for CD.

Methods: We evaluated the effects of an individualized, food-based diet (CD-TREAT), with similar composition to EEN, on the gut microbiome, inflammation and clinical response in a rat model, healthy adults, and children with relapsing CD. Read More

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December 2018

Prognostic value of progesterone receptor in solid pseudopapillary neoplasm of the pancreas: evaluation of a pooled case series.

BMC Gastroenterol 2018 Dec 14;18(1):187. Epub 2018 Dec 14.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. However, the relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not been elucidated so far. The aim of our study was to evaluate the prognostic value of PR in SPNP. Read More

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December 2018

Understanding Therapeutic Concepts in Crohn's Disease.

Authors:
Gilles Rg Monif

Clin Med Insights Gastroenterol 2018 3;11:1179552218815169. Epub 2018 Dec 3.

Infectious Diseases Inc., Bellevue, NE, USA.

For more than a decade, the therapeutic focus for Crohn's disease has remained fixed at temporary arrestment of symptomology. The Centers for Disease Control and Prevention (CDC) lists Crohn's disease as a disease entity without current cure. Biologics in combination with antibiotics can frequently achieve remissions. Read More

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December 2018
1 Read

Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma.

BMC Gastroenterol 2018 Dec 13;18(1):186. Epub 2018 Dec 13.

Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, People's Republic of China.

Background: To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers.

Methods: Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), AFP and levels as well as the numbers of neutrophils and lymphocytes of all enrolled patients were collected. The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Read More

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December 2018
2.365 Impact Factor

Hepatocellular Carcinoma Surveillance: An effective but complex process.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Division of Digestive and Liver Diseases, UT Southwestern Medical Center; Department of Clinical Sciences, UT Southwestern Medical Center.

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December 2018

RE: No Association Between Screening for Hepatocellular Carcinoma and Reduced Cancer-Related Mortality in Patients with Cirrhosis.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, Alfred Health, Melbourne, Victoria, Australia; Monash University, Melbourne, Victoria, Australia.

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December 2018

There is an unmet need for test-specific, validated symptom questionnaires for breath tests in adults.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Medical University of Graz, Universitätsklinik für Innere Medizin, Abteilung für Gastroenterologie und Hepatologie Auenbrugger Platz 15, 8011 Graz, Austria.

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December 2018

Screening for hepatocellular carcinoma to improve cancer-related mortality: Looking behind when we should be looking ahead.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Division of Gastroenterology, Department of Medicine, University of California, San Francisco; Division of Transplant Surgery, Department of Surgery, University of California, San Francisco.

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December 2018

Prebiotics Versus Low Fodmap Diet: An Interpretative Nightmare.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Department of Gastroenterology, Monash University and Alfred Health, Melbourne, Victoria Australia. Electronic address:

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December 2018

Screening For Hepatocellular Carcinoma In Cirrhosis: Challenges And Unresolved Issues.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, Larner College of Medicine, University of Vermont; University of Vermont Medical Center. Electronic address:

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December 2018

Exclusive enteral nutrition with concomitant early thiopurine use was effective in maintaining steroid-free remission in a Southeast Asian cohort of children with Crohn's disease.

BMC Gastroenterol 2018 Dec 12;18(1):185. Epub 2018 Dec 12.

Gastroenterology Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, KK Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Background: Exclusive enteral nutrition (EEN) is as effective as corticosteroids in inducing remission in children with Crohn's disease (CD). However, over 50% of these children relapse by 12 months of diagnosis. Thiopurines are commonly prescribed as maintenance therapy for CD, but evidence for its efficacy is controversial. Read More

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December 2018

No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases.

Gastroenterology 2018 Dec 6. Epub 2018 Dec 6.

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Background & Aims: Patients with inflammatory bowel diseases (IBD) who have post-inflammatory polyps (PIPs) have an increased risk of colorectal neoplasia (CRN). European guidelines propose that patients with PIPs receive more frequent surveillance colonoscopies, despite limited evidence of this increased risk. We aimed to define the risk of CRN and colectomy in patients with IBD and PIPs. Read More

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December 2018

Specific Bacteria and Metabolites Associated with Response to Fecal Microbiota Transplantation in Patients with Ulcerative Colitis.

Gastroenterology 2018 Dec 6. Epub 2018 Dec 6.

University of New South Wales, Sydney, Australia. Electronic address:

Background & Aims: Fecal microbiota transplantation (FMT) can induce remission in patients with ulcerative colitis (UC). In a randomized, controlled trial of FMT in patients with active UC, we aimed to identify bacterial taxonomic and functional factors associated with response to therapy.

Methods: We performed a double-blind trial of 81 patients with active UC randomly assigned to groups that received an initial colonoscopic infusion and then intensive multi-donor FMT or placebo enemas, 5 days/week for 8 weeks. Read More

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December 2018

Large-scale Genome-wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

Gastroenterology 2018 Dec 6. Epub 2018 Dec 6.

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address:

Background & Aims: Genome-wide association studies (GWASs) have associated approximately 50 loci with risk of colorectal cancer (CRC)-nearly one-third of these loci were initially associated with CRC in studies conducted in East Asian populations. We conducted a GWAS of East Asians to identify CRC risk loci and evaluate the generalizability of findings from GWAS of European populations to Asian populations METHODS: We analyzed genetic data from 22,775 patients with CRC (cases) and 47,731 individuals without cancer (controls) from 14 studies in the Asia Colorectal Cancer Consortium. First, we performed a meta-analysis of 7 GWAS (10,625 cases and 34,595 controls) and identified 46,554 promising risk variants for replication by adding them to the Multi-Ethnic Global Array (MEGA) for genotype analysis in 6445 cases and 7175 controls. Read More

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December 2018

Challenges, Considerations, and Principles to Guide Trials of Combination Therapies for Chronic HBV.

Gastroenterology 2018 Dec 4. Epub 2018 Dec 4.

Executive Director, Forum for Collaborative Research, University of California, Berkeley, School of Public Health, Washington, District of Columbia. Electronic address:

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December 2018

Globalization and Gastroenterology: A Role for Women in the AGA.

Gastroenterology 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine, Baylor College of Medicine, Houston Texas; Baylor Global Health, Houston, Texas. Electronic address:

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December 2018
2 Reads

Aspirin and Cancer Prevention in the Elderly: Where Do We Go from Here?

Gastroenterology 2018 Dec 4. Epub 2018 Dec 4.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.

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December 2018

Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.

BMC Gastroenterol 2018 Dec 10;18(1):184. Epub 2018 Dec 10.

Faculty of Health Sciences, BIOGEN Research Group, Universidad de Santander, Avenida 4 10N-61, El Bosque, Cúcuta, Colombia.

Background: Gastric Cancer is highly prevalent and deadly worldwide. In Colombia, it is the most lethal form of cancer. Some single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes have been associated with an anti-inflammatory environment and a Th2 profile in detriment of the antitumor Th1 response. Read More

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December 2018

The diagnostic ability of SPECT/CT fusion imaging for gastrointestinal bleeding: a retrospective study.

BMC Gastroenterol 2018 Dec 10;18(1):183. Epub 2018 Dec 10.

Department of Radiology, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.

Background: Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to localize the sites of bleeding. The purpose of this study was to retrospectively assess the capabilities of SPECT/CT in the diagnosis of gastrointestinal bleeding by a comparison with planar imaging alone as well as planar and SPECT. Read More

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December 2018

Racial Disparities in Incidence of Young-onset Colorectal Cancer and Patient Survival.

Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background & Aims: Increasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (age <50 years) adults, in 2 time periods.

Methods: Using data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons ages 20 - 54 years) from 1992 through 2014, for different time periods (1992-1996 vs 2010-2014) and races (white vs black). Read More

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December 2018
6 Reads

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption.

Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801. Electronic address:

Background & Aims: The nuclear receptor subfamily 0 group B member 2 (NR0B2, also called SHP) is expressed at high levels in liver and intestine. Postprandial fibroblast growth factor 19 (human FGF19, mouse FGF15) signaling increases the transcriptional activity of SHP. We studied the functions of SHP and FGF19 in intestines of mice, including their regulation of expression of the cholesterol transporter NPC1-like intracellular cholesterol transporter 1 (NPC1L1) and cholesterol absorption. Read More

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December 2018
2 Reads

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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October 2018
2 Reads

Risk of Post-polypectomy Bleeding With Uninterrupted Clopidogrel Therapy in an Industry-independent, Double-blind, Randomized Trial.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine & Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China (SAR); State Key Laboratory of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China (SAR).

Background & Aims: Guidelines recommend withholding clopidogrel 7 days before polypectomy to reduce bleeding risk, but these were written based on limited evidence. We investigated whether uninterrupted clopidogrel therapy increases the risk of delayed post-polypectomy bleeding in patients undergoing colonoscopy.

Methods: We identified patients receiving clopidogrel for cardiovascular disease undergoing elective colonoscopies in Hong Kong, from 28 February 2012 through 11 April 2018. Read More

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October 2018
2 Reads

Risk factor for steatorrhea in pediatric chronic pancreatitis patients.

BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More

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December 2018
1 Read

Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis.

BMC Gastroenterol 2018 Dec 5;18(1):181. Epub 2018 Dec 5.

Department of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi Province, China.

Background: This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes in common carotid artery elasticity and vascular function.

Methods: Two-hundred seventeen patients with chronic viral hepatitis caused by either hepatitis B virus (HBV) or hepatitis C virus (HCV) were enrolled. Read More

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December 2018
1 Read

Interleukin 1 Upregulates MicroRNA 135b to Promote Inflammation-associated Gastric Carcinogenesis in Mice.

Gastroenterology 2018 Nov 30. Epub 2018 Nov 30.

Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan; AMED-CREST, AMED, Japan Agency for Medical Research and Development, Tokyo, Japan; WPI Nano-Life Science Institute (Nano-LSI), Kanazawa University, Kanazawa, Japan. Electronic address:

Background & Aims: Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation. Specific changes in gene expression in epithelial cells are difficult to monitor due to the heterogeneity of the tissue. We investigated epithelial cell-specific changes in microRNA expression during gastric inflammation and gastritis-associated carcinogenesis in mice. Read More

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November 2018
8 Reads

The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial.

Clin Med Insights Gastroenterol 2018 26;11:1179552218811834. Epub 2018 Nov 26.

Universidade do Estado de Santa Catarina (UDESC), Florianópolis, Brazil.

Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuromuscular electrical stimulation (NMES) on the muscular and functional capacity of patients with cirrhosis classified as Child-Pugh B and C. A total of 72 patients diagnosed with cirrhosis will be recruited and randomized to perform an NMES protocol for 50 minutes, 3 times a week, for 4 weeks. Read More

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November 2018
1 Read

Covering the Cover.

Gastroenterology 2018 Nov 29. Epub 2018 Nov 29.

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November 2018

Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis.

Gastroenterology 2018 Nov 28. Epub 2018 Nov 28.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, United States; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, United States.

Background & Aims: microRNAs (miRNAs) are small non-coding RNAs that bind to 3'UTR regions of mRNAs to promote their degradation or block their translation. Mice with disruption of the trefoil factor 1 gene (Tff1) develop gastric neoplasms. We studied these mice to identify conserved miRNA networks involved in gastric carcinogenesis. Read More

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November 2018
1 Read

Temporal Trends in (Screen/ Non-adherence/Interval) Detected Colorectal Cancer. A Possible Healthcare System Quality Measure.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine - Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX, United States; Section of Gastroenterology, Michael E. DeBakey VA Medical Center (MEDVAMC), Houston, TX, United States. Electronic address:

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October 2018

Characterization of intrahepatic cholangiocarcinoma after curative resection: outcome, prognostic factor, and recurrence.

BMC Gastroenterol 2018 Dec 4;18(1):180. Epub 2018 Dec 4.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, 5 Fu-Hsing Street, Kwei-Shan District, Taoyuan City, 33305, Taiwan.

Background: Intrahepatic cholangiocarcinoma (ICC) is a relatively rare subtype of cholangiocarcinoma. The study herein gathered experience of surgical treatment for ICC, and aimed to analyze the prognosis of patients who had received curative-intent liver resection.

Methods: A total of 216 patients who had undergone curative-intent liver resection for ICC between January 1977 and December 2014 was retrospectively reviewed. Read More

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December 2018
1 Read

Development and external validation of a prognostic nomogram for acute decompensation of chronic hepatitis B cirrhosis.

BMC Gastroenterol 2018 Dec 3;18(1):179. Epub 2018 Dec 3.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background: Acute decompensation (AD) has been shown to be associated with a high mortality rate for cirrhosis patients. This study aimed to develop a prognostic nomogram to evaluating the individual prognosis for AD of cirrhosis in chronic hepatitis B (CHB).

Methods: The nomogram was developed using data from a retrospective study on 509 patients hospitalized for AD of CHB cirrhosis from October 2008 to February 2014 at the Beijing Ditan Hospital, Capital Medical University. Read More

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December 2018

Prevalence of and risk factors for fatty liver in the general population of Northern Italy: the Bagnacavallo Study.

BMC Gastroenterol 2018 Nov 28;18(1):177. Epub 2018 Nov 28.

Department of Internal Medicine, Ospedale di Faenza, AUSL Romagna, Faenza, Italy.

Background: The estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.

Methods: The Bagnacavallo Study was performed between October 2005 and March 2009. All the citizens of Bagnacavallo (Ravenna, Italy) aged 30 to 60 years as of January 2005 were eligible. Read More

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November 2018
2 Reads

Stapleless laparoscopic left lateral sectionectomy for hepatocellular carcinoma: reappraisal of the Louisville statement by a young liver surgeon.

BMC Gastroenterol 2018 Nov 28;18(1):178. Epub 2018 Nov 28.

Department of Surgery, Linkou Chang Gung Memorial Hospital, No.5, Fuxing St, Guishan Dist, Taoyuan City, 33305, Taiwan, Republic of China.

Background: Laparoscopic liver resection has been regarded as the standard treatment for liver tumors located at the left lateral liver sector. However, few studies have reported the results of laparoscopic left lateral sectionectomy (LLS) for HCC, not to mention the feasibility of this emerging technique for the less experienced liver surgeons. The current study would reappraise the Louisville statement by examining the outcome of LLS performed by a young liver surgeon. Read More

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November 2018
2.365 Impact Factor

Braun anastomosis lowers the incidence of delayed gastric emptying following pancreaticoduodenectomy: a meta-analysis.

BMC Gastroenterol 2018 Nov 26;18(1):176. Epub 2018 Nov 26.

Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China.

Background: Delayed gastric emptying (DGE) is one of the most frequent complications following pancreaticoduodenectomy. This meta-analysis aimed to evaluate the impact of Braun enteroenterostomy on DGE following pancreaticoduodenectomy.

Methods: A systematic review of the literature was performed to identify relevant studies. Read More

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November 2018
5 Reads

Modeling Human Digestive Diseases with CRISPR-Cas9-modified Organoids.

Gastroenterology 2018 Nov 23. Epub 2018 Nov 23.

Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.

Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells as organoids that display structural and phenotypic features of healthy and diseased epithelial tissues. Organoids derived from patients' tissues are used as models of disease and to test drugs. CRISPR-Cas9 technology can be used to genetically engineer organoids for studies of monogenic diseases and cancer. Read More

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November 2018
2 Reads

Correction.

Authors:

Gastroenterology 2018 12 23;155(6):2027. Epub 2018 Nov 23.

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December 2018

Correction.

Authors:

Gastroenterology 2018 12 23;155(6):2027. Epub 2018 Nov 23.

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December 2018

Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate to Severe Ulcerative Colitis.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

University of Vienna, Vienna, Austria.

Background & Aims: αβ integrin is a validated target in inflammatory bowel disease. This randomized, phase 2b, placebo-controlled, double-blind study evaluated the efficacy and safety of the anti-αβ antibody abrilumab in patients with moderate-to-severe ulcerative colitis (UC) despite treatment with conventional therapies.

Methods: Patients (total Mayo Score 6-12, rectosigmoidoscopy score ≥2) with inadequate response or intolerance to conventional therapies were randomized to receive subcutaneous abrilumab (7, 21, or 70 mg) on day 1, weeks 2 and 4, and every 4 weeks; abrilumab 210 mg on day 1; or placebo. Read More

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November 2018
4 Reads

Histone Demethylase JMJD2D Interacts with Beta-catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology,School of Life Sciences, Xiamen University, Xiamen, China. Electronic address:

Background & Aims: Wnt signaling contributes to development of colorectal cancer (CRC). We studied interactions between lysine demethylase 4D (KDM4D or JMJD2D) and beta-catenin, a mediator of Wnt signaling, in CRC cell lines and the effects on tumor formation in mice.

Methods: We obtained colorectal tumor specimens and surrounding non-tumor colon tissues (controls) from patients undergoing surgery in China; levels of JMJD2D were measured by immunohistochemical or immunoblot analysis. Read More

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November 2018
2 Reads

Reply.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

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November 2018

Thiopurine Therapy in Inflammatory Bowel Diseases: Making New Friends Should Not Mean Losing Old Ones.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Gastroenterology and Hepatology, AG&M Research Institute, Amsterdam, the Netherlands.

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November 2018
1 Read

Reply.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science and, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Chinese University of Hong Kong, Hong Kong, China.

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November 2018
1 Read

Atg5 in Pancreatic Tumorigenesis and Progression: Dosage Matters.

Authors:
Haiyong Han

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, Arizona. Electronic address:

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November 2018

How to Approach a Patient With Refractory or Recurrent Benign Esophageal Stricture.

Authors:
Peter D Siersema

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.

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November 2018

Reply.

Gastroenterology 2018 Nov 23. Epub 2018 Nov 23.

Service d'Hépatologie, AP-HP, Hôpital Jean Verdier, Bondy, France and Inserm UMR-1162, "Functional Genomics of Solid Tumors", Université Paris Descartes, Université Paris Diderot, Labex Oncoimmunology, Equipe labellisée Ligue contre le Cancer, Paris, France.

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November 2018

Reply.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, California.

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November 2018
1 Read

High Mucosal Plasma Cell Numbers and Low Serum TREM-1 Levels May Predict Nonresponsiveness to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease.

Gastroenterology 2018 Nov 22. Epub 2018 Nov 22.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.

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November 2018
4 Reads