7,696 results match your criteria Gastroenterologie Clinique et Biologique [Journal]


Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018
16.716 Impact Factor

Recurrence of hereditary hemorrhagic telangiectasia after liver transplantation: clinical implications and physiopathological insights.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Gustave Roussy Cancer Campus, Département de Biologie et Pathologie Médicales, Service de Pathologie Moléculaire, Villejuif.

Liver transplantation (LT) has been proposed as a curative treatment in hereditary hemorrhagic telangiectasia (HHT) with severe hepatic involvement. We provide a long-term evaluation of graft status after LT for HHT, with a focus on the risk of recurrence. The present study included all patients prospectively followed-up after LT for HHT in the Lyon liver transplant unit from 1993 to 2010, with a survival of more than 1 year. Read More

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December 2018

Molecular diagnosis of Helicobacter pylori infection in gastric biopsies: Evaluation of the Amplidiag H. pylori + ClariR assay.

Helicobacter 2018 Dec 12:e12560. Epub 2018 Dec 12.

Bacteriology, Cochin Hospital, University of Paris-Descartes, Institut Pasteur, Paris, France.

Background: Adapted treatments for Helicobacter pylori infection, guided by determining antimicrobial resistance, are associated with high eradication rates. We evaluated the performance of the Amplidiag H. pylori + ClariR PCR assay (Amplidiag ) for detecting H. Read More

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December 2018

There is an unmet need for test-specific, validated symptom questionnaires for breath tests in adults.

Gastroenterology 2018 Dec 10. Epub 2018 Dec 10.

Medical University of Graz, Universitätsklinik für Innere Medizin, Abteilung für Gastroenterologie und Hepatologie Auenbrugger Platz 15, 8011 Graz, Austria.

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December 2018

Optimized imaging of the lower abdomen and pelvic region in hepatocyte-specific MRI: evaluation of a whole-abdomen first-pass shuttle protocol in patients with neuroendocrine neoplasms.

Acta Radiol 2018 Dec 12:284185118817936. Epub 2018 Dec 12.

1 Klinik für Radiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Gadoxetic acid (Gd-EOB) has shown its advantages in hepatic tumor evaluation besides its disadvantages in extrahepatic staging due to its short hemodynamic interval. This results in the dilemma of which contrast agent to choose for whole abdominal magnetic resonance imaging (MRI).

Purpose: To evaluate the achievable contrast of a shuttle protocol for Gd-EOB MRI with accelerated 3D-T1-weighted sequences enabling complete dynamic liver imaging plus first-pass pelvic imaging. Read More

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December 2018

[Stereotactic hypofractionated radiation therapy as a bridge to transplantation for hepatocellular carcinoma: Case report of a complete pathological response and review of the literature].

Cancer Radiother 2018 Dec 26;22(8):797-801. Epub 2018 Oct 26.

Département d'oncoradiothérapie, institut Claudius-Regaud, institut universitaire du cancer de Toulouse- Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France. Electronic address:

Patients with hepatocellular carcinoma who are on liver transplant waiting list usually require local treatment to limit any risk of tumour growth. Historically percutaneous radiofrequency ablation or transarterial chemoembolization represented the major therapeutic alternatives. Depending on the size, or the topography of the lesion these two techniques may not be feasible. Read More

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December 2018

New MRI features improve subtype classification of hepatocellular adenoma.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

CHU de Bordeaux, Service d'imagerie diagnostique et interventionnelle, Hôpital Haut-Lévêque, F-33604, Pessac, France.

Objective: MRI is crucial for the classification of hepatocellular adenomas (HCA) into subtypes. Our objective was to review and increase MRI criteria for subtype classification and define the limits.

Methods: Pathological and radiological data of 116 HCAs were retrospectively analyzed to investigate MRI features of HCA pathological subtypes. Read More

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December 2018

Guideline recommendations for treatment of patients with inflammatory bowel diseases are not implemented in clinical practice-results of a non-representative survey.

Int J Colorectal Dis 2018 Dec 7. Epub 2018 Dec 7.

Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12200, Berlin, Germany.

Purpose: There is a growing evidence for over-, under-, or misuse of health care in patients with inflammatory bowel disease. Most studies looked at treatment variability or used quality measures, which mostly capture supportive interventions rather than treatment of IBD in itself. We aimed to evaluate if current recommendations in clinical practice guidelines regarding the medical treatment of patients with inflammatory bowel diseases are being followed in Germany. Read More

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December 2018

Postprandial lipid absorption in seven heterozygous carriers of deleterious variants of MTTP in two abetalipoproteinemic families.

J Clin Lipidol 2018 Oct 24. Epub 2018 Oct 24.

Service de Biochimie métabolique, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix (AP-HP), Paris, France; Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, Unité de Technologies Chimiques et Biologiques pour la Santé, U 1022 INSERM, UMR 8258 CNRS, Paris, France.

Background: Abetalipoproteinemia, a recessive disease resulting from deleterious variants in MTTP (microsomal triglyceride transfer protein), is characterized by undetectable concentrations of apolipoprotein B, extremely low levels of low-density lipoprotein cholesterol in the plasma, and a total inability to export apolipoprotein B-containing lipoproteins from both the intestine and the liver.

Objective: To study lipid absorption after a fat load and liver function in 7 heterozygous relatives from 2 abetalipoproteinemic families, 1 previously unreported.

Results: Both patients are compound heterozygotes for p. Read More

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October 2018

[Necrotizing esophagitis by stress-cardiomyopathy with right ventricular insufficiency].

Med Klin Intensivmed Notfmed 2018 Dec 10. Epub 2018 Dec 10.

Klinik für Gastroenterologie, Endokrinologie, Diabetologie und Allgemeine Innere Medizin, Klinikum Kassel, Kassel, Deutschland.

Acute necrotizing esophagitis ("black esophagus") is defined as complete necrosis of the esophageal mucosa, which typically affects the entire circumference. We report a case of a healthy 62-year-old woman, who became hemodynamically unstable due to stress cardiomyopathy with acute right heart failure. Transfusion-dependent anemia occurred 24 h later and an upper gastrointestinal endoscopy revealed a black discoloured mucosa of the distal esophagus. Read More

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December 2018
1 Read

Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.

Nat Commun 2018 12 7;9(1):5235. Epub 2018 Dec 7.

INSERM, UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Institut Universitaire d'Hématologie, Paris, 75010, France.

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation through various mechanisms including hepatitis B virus (HBV) and adeno-associated virus type 2 (AAV2) insertions, enhancer hijacking and recurrent CCNA2 fusions. Cyclin A2 or E1 alterations define a homogenous entity of aggressive HCC, mostly developed in non-cirrhotic patients, characterized by a transcriptional activation of E2F and ATR pathways and a high frequency of RB1 and PTEN inactivation. Read More

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December 2018

[Current Developments in Nutritional Therapy of Intensive Care Patients].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1759-1764. Epub 2018 Dec 3.

Medizinische Klinik III (Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin) Universitätsklinikum, RWTH-Aachen.

The goals of nutritional therapy for critically ill patients are the enteral or parenteral provision of calories, proteins, electrolytes, vitamins, trace elements and fluids. The metabolism of critically ill patients is characterized by a catabolic stress condition, which is caused by a systemic inflammatory response and is associated with an increased infection rate, occurrence of multiple organ failure and increased mortality.Traditionally, nutritional therapy has been considered as an "adjunctive" therapy for critically ill patients with the primary goal of providing energy to maintain muscle mass. Read More

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December 2018
1 Read

[How important are proton pump inhibitors in the prevention of stress ulcers and stress-associated gastrointestinal bleeding in ICU patients?]

Med Klin Intensivmed Notfmed 2018 Nov 30. Epub 2018 Nov 30.

Klinik III für Innere Medizin, Herzzentrum, Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

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November 2018

[Treatment de-escalation in inflammatory bowel diseases].

Authors:
Vered Abitbol

Presse Med 2018 Nov - Dec;47(11-12 Pt 1):931-933

Hôpital Cochin, service de gastroentérologie, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address:

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December 2018

Prolonged retention of prophylactic pancreatic stents is not associated with increased complications.

Pancreatology 2018 Nov 22. Epub 2018 Nov 22.

Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Universitätsklinikum Frankfurt, Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

Objectives: The risk of post-ERCP pancreatitis (PEP) can be reduced effectively by the placement of a self dislodging pancreatic stent. The present study analyzed whether a prolonged interval until stent passage evaluation and removal of retained stents is associated with an increased risk for clinically relevant complications.

Methods: In the retrospective study 182 patients receiving a pancreatic stent for PEP prophylaxis were included and clinical data and complications until documented spontaneous stent dislodgement or removal were analyzed. Read More

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November 2018
4 Reads

Living with an irritable bowel syndrome

Rev Prat 2017 12;67(10):1095-1096

Association des patients souffrant du syndrome de l'intestin irritable.

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December 2017

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.

Nat Commun 2018 12 3;9(1):4832. Epub 2018 Dec 3.

Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.

The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence progression of extramucosal tumors is poorly understood. Here we provide evidence implying that Prevotella heparinolytica promotes the differentiation of Th17 cells colonizing the gut and migrating to the bone marrow (BM) of transgenic Vk*MYC mice, where they favor progression of multiple myeloma (MM). Lack of IL-17 in Vk*MYC mice, or disturbance of their microbiome delayed MM appearance. Read More

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December 2018

[Diagnosis and Treatment of Familial Hypercholesterolemia].

Praxis (Bern 1994) 2018 Nov;107(24):1345-1353

1 Klinik für Endokrinologie, Diabetologie, Osteologie und Stoffwechselkrankheiten, Kantonsspital St. Gallen.

Diagnosis and Treatment of Familial Hypercholesterolemia Abstract. Familial hypercholesterolemia secondary to heterozygous mutations in the LDL receptor, Apolipoprotein B or PCSK9 gene is characterized by 2- to 3-fold elevated LDL cholesterol levels, premature atherosclerosis and extravascular cholesterol deposits (tendon xanthomata, corneal arcus). The same phenotype may occur if a person carries several LDL cholesterol rising polymorphisms (polygenic FH). Read More

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November 2018
2 Reads

Reply.

Gastroenterology 2018 Nov 23. Epub 2018 Nov 23.

Service d'Hépatologie, AP-HP, Hôpital Jean Verdier, Bondy, France and Inserm UMR-1162, "Functional Genomics of Solid Tumors", Université Paris Descartes, Université Paris Diderot, Labex Oncoimmunology, Equipe labellisée Ligue contre le Cancer, Paris, France.

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November 2018

Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals.

Clin Gastroenterol Hepatol 2018 Nov 21. Epub 2018 Nov 21.

Division of Gastroenterology & Hepatology, Lausanne University Hospital, Lausanne, Switzerland; Crohn and Colitis Center, Gastroentérologie Beaulieu SA, Lausanne, Switzerland.

Background & Aims: Inflammatory bowel disease (IBD) scoring systems combine patient-reported data with physicians' observations to determine patient outcomes, but these systems are believed to have limitations. We used real-world data from a large IBD cohort in Switzerland to compare results between patients and healthcare professionals' from scoring systems for Crohn's disease (CD) and ulcerative colitis (UC).

Methods: We collected data from the Swiss IBD cohort, beginning in 2006, using 2453 reports for 1385 patients (52% female, 58% with CD). Read More

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November 2018
5 Reads

[Wilson's disease or hepatolenticular degeneration].

Ther Umsch 2018 Nov;75(4):241-248

6 Gastroenterologie & Hepatologie, Kantonsspital Baselland Liestal.

Wilson's disease or hepatolenticular degeneration Abstract. Wilson's disease, or hepatolenticular degeneration, is a rare inherited disorder of copper metabolism. The most common clinical presentations are liver disease and / or neuro-psychiatric manifestations. Read More

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November 2018
7 Reads

[PAPA syndrome with Crohn's disease and primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome].

Hautarzt 2018 Nov 22. Epub 2018 Nov 22.

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Rostock, Rostock, Deutschland.

Background: The PAPA syndrome, an acronym for pyogenic sterile arthritis, pyoderma gangraenosum and acne, is an autosomal dominant hereditary disease which is caused by a mutation in the PSTPIP1 ("proline-serine-threonine phosphatase interacting protein 1") gene located on chromosome 15 and encodes the proline-serine-threonine phosphatase-interacting protein 1. An association with Crohn's disease (CD), autoimmune diseases of the liver and PAPA syndrome has not yet been reported in the literature.

Objective: To thoroughly investigate a family with three affected members (mother and 2 children) with newly diagnosed PAPA syndrome and intestinal and hepatobiliary symptoms. Read More

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November 2018
5 Reads

Quantitative trace element mapping in liver tissue from patients with Wilson`s disease determined by micro X-ray fluorescence.

J Trace Elem Med Biol 2019 Jan 27;51:42-49. Epub 2018 Sep 27.

Medizinische Universität Wien, Klinisches Institut für Klinische Pathologie, Austria.

Aims: of this investigation were to quantify copper (Cu), iron (Fe) and zinc (Zn) along with sulphur (S) and phosphorus (P) in hepatocytes and connective tissue in liver section from patients with Wilson´s disease (WD) by micro Synchrotron X-ray fluorescence (μ-SRXRF). Secondly to establish two-dimensional μ-SRXRF element mappings for comparison with histologically prepared slices, and thirdly to assess whether elemental distributions are associated.

Methods: Archival liver tissues from twelve patients with end-stage cirrhosis or fulminant WD were investigated. Read More

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January 2019
2 Reads

[Chronic granulomatous disease as a rare differential diagnosis of inflammatory bowel disease].

Z Gastroenterol 2018 Dec 22;56(12):1507-1512. Epub 2018 Nov 22.

I. Medizinische Klinik und Poliklinik, Gastroenterologie und Hepatologie, Universitätsmedizin Mainz.

Background:  Chronic granulomatous disease is a rare disease with a prevalence of approximately 150 cases in Germany. An intestinal manifestation that mimics chronic inflammatory bowel disease (IBD) has only been described in a few cases. As a result of a deficient superoxide-synthesis, frequent and recurrent infections caused by rare pathogens have been described. Read More

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December 2018
2 Reads

The impact of steatosis on liver regeneration.

Horm Mol Biol Clin Investig 2018 Nov 21. Epub 2018 Nov 21.

Centre de Recherche sur l'Inflammation, Faculté de Médecine Xavier Bichat, Inserm U1149, Université Paris Diderot, Sorbonne Paris Cité, 16 Rue Huchard, 75018 Paris, France, Phone: (+33) 1 57277530.

Alcoholic and non-alcoholic fatty liver diseases are the leading causes of cirrhosis in Western countries. These chronic liver diseases share common pathological features ranging from steatosis to steatohepatitis. Fatty liver is associated with primary liver graft dysfunction, a higher incidence of complications/mortality after surgery, in correlation with impaired liver regeneration. Read More

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November 2018
5 Reads

Liver safety parameters of ulipristal acetate for the treatment of uterine fibroids: a comprehensive review of the clinical development program.

Expert Opin Drug Saf 2018 Dec 29;17(12):1225-1232. Epub 2018 Nov 29.

c Medical Affairs and Safety Departments, PregLem S.A. , Service d'Hepato-gastroenterologie et Transplantation, Hôpital Saint-Eloi, INSERM-1183 , Montpellier , France.

Introduction: Uterine fibroids are benign tumors within the uterine wall affecting women. Ulipristal acetate 5 mg was first authorized in the European Union on 23 February 2012, with a post-marketing exposure estimated to be more than 765,000 patients so far. During the post-marketing experience, sporadic cases of liver injury and hepatic failure were reported. Read More

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December 2018
16 Reads

[Electrocardiographic and echocardiographic abnormalities in patients with cirrhosis due to viral hepatitis B: about 60 cases reported in the Hepatogastroenterologic Department at the Aristide Le Dantec Hospital in Dakar (HALD)].

Pan Afr Med J 2018 25;30:169. Epub 2018 Jun 25.

Service d'Hépato, Gastroentérologie HALD, Senegal.

This study aimed to evaluate the electrocardiographic abnormalities in patients with cirrhosis due to viral hepatitis B and to identify their determinants. We conducted a prospective study in the Hepatogastroenterologic Department and in the Department of Cardiology at the Aristide Le Dantec Hospital in Dakar over a period of 8 months. All patients with cirrhosis due to viral hepatitis B and without a history of heart disease were included in the study. Read More

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December 2018
8 Reads

Biologika in der Therapie kindlicher chronisch-entzündlicher Darmerkrankungen.

Authors:
Philip Bufler

Drug Res (Stuttg) 2018 Nov 19;68(S 01):S15. Epub 2018 Nov 19.

Klinik für Pädiatrie m. S. Gastroenterologie, Nephrologie und Stoffwechselerkrankungen, Charité - Universitätsmedizin Berlin.

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November 2018

[Hepatitis delta virus replication and the role of the small hepatitis delta protein S-HDAg].

Med Sci (Paris) 2018 Oct 19;34(10):833-841. Epub 2018 Nov 19.

Inserm, U1052 - UMR CNRS 5286, Centre de recherche en cancérologie de Lyon, Lyon, France - Laboratoire de microbiologie clinique, groupe des Hôpitaux universitaires de Paris-Seine Saint Denis, UFR santé médecine, biologie humaine, université Paris 13, Bobigny, France.

Hepatitis delta virus (HDV) is a mammalian defective virus. Its genome is a small single-stranded circular RNA of approximately 1,680 nucleotides. To spread, HDV relies on hepatitis B virus envelope proteins that are needed for viral particle assembly and egress. Read More

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October 2018
11 Reads

Red Blood cell IMPDH activity in adults and children with or without azathioprine: relationship between thiopurine metabolites, ITPA and TPMT activities.

Basic Clin Pharmacol Toxicol 2018 Nov 19. Epub 2018 Nov 19.

Université de Lyon, Université Lyon 1, UMR CNRS 5305, Pharmacie Clinique, Pharmacocinétique et Evaluation du Médicament, Lyon, France.

Inosine MonoPhosphate DeHydrogenase (IMPDH) is considered as the limiting enzyme of thiopurine metabolism for the formation of 6-Thioguanine nucleotides (6-TGN). No data are available on the influence of RBCs IMPDH activity on the metabolism of thiopurine drugs in subjects with IBD. The aim of this study was 1/ To carry out a phenotypic study of RBCs IMPDH activity in adults and children treated or not with azathioprine (AZA) for autoimmune diseases. Read More

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November 2018
6 Reads

Sporadic pancreatic neuroendocrine tumor: Surgery of the primary tumor.

J Visc Surg 2018 Dec 15;155(6):483-492. Epub 2018 Nov 15.

Service de chirurgie generale, digestive et endocrinienne, hôpital Robert-Debré, université de Reims Champagne-Ardenne, 51100 Reims, France. Electronic address:

The management of patients with sporadic pancreatic neuroendocrine tumors (PNET) is multi-disciplinary and often, multimodal. Surgery has a large part in treatment because it is the only potentially curative therapeutic modality if resection can be complete. The update reviews the operative indications and the different surgical techniques available (including parenchymal-sparing surgery) to treat the primary lesion according to patient status, preoperative work-up and whether the tumor is functioning or not. Read More

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December 2018
3 Reads

[17-Year-Old Pupil with Cervical Lymphe Node Masses].

Dtsch Med Wochenschr 2018 Nov 15;143(23):1671-1672. Epub 2018 Nov 15.

Klinik für Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Brüder, Regensburg.

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November 2018
2 Reads

High Seroprevalence of anti-Hepatitis E antibodies in Austrian patients with Autoimmune Hepatitis.

Liver Int 2018 Nov 15. Epub 2018 Nov 15.

Division of Gastroenterology and Hepatology Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Background & Aims: Increasing numbers of autochthonous hepatitis-E-virus (HEV) infections have been reported in Europe. Chronic infections have been shown in immune-compromised patients after solid-organ transplantation. HEV might be a possible trigger for AIH and might cause disease flares or relapses in the further course of disease. Read More

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November 2018
4 Reads

Long-Term Effect of Rifaximin with and without Lactulose on the Active Bacterial Assemblages in the Proximal Small Bowel and Faeces in Patients with Minimal Hepatic Encephalopathy.

Dig Dis 2018 Nov 14:1-9. Epub 2018 Nov 14.

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-Von-Guericke University Magdeburg, Magdeburg,

Background: Gut microbiota play an essential role in the pathogenesis of hepatic encephalopathy (HE). Treatment strategies are directed to modulate intestinal microbiota profiles and their function by the administration of the non-absorbable disaccharide lactulose and the non-absorbable antibiotic rifaximin, which are required for long terms, but little is known on their long-term effect on gut microbiota composition and function.

Aim: To characterize the active bacterial assemblages in duodenum and faeces in patients with minimal HE (MHE) before, during and after long-term therapy with rifaximin. Read More

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November 2018
3 Reads

Contrast-Enhanced Sonography in Patients with Hyposplenia: A Retrospective Analysis in Forty-Three Patients.

Digestion 2018 Nov 13:1-6. Epub 2018 Nov 13.

Interdisziplinäre Ultraschallzentrum, Universitätsklinikum Gießen und Marburg, Philipps Universität Marburg, Marburg, Germany.

Purpose: In contrast to splenomegaly, the clinical value of a small spleen (hyposplenia) is unclear. Contrast-enhanced ultrasound (CEUS) has not been investigated systematically in hyposplenia.

Methods: Between February 2005 and January 2017, 43 patients with hyposplenia (< 7 × 3 cm) were examined by B-mode ultrasound (US) and CEUS. Read More

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November 2018
1 Read

[Gastrointestinal innovations].

MMW Fortschr Med 2018 11;160(Suppl 3):58-63

Medizinische Klinik und Poliklinik II, Klinikum der Universität München, Marchioninistr. 15, D-81377, München, Deutschland.

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November 2018
1 Read

[Hepatitis C: Innovations in the last 10 years].

MMW Fortschr Med 2018 11;160(Suppl 3):66-70

I. Medizinische Klinik und Poliklinik, Gastroenterologie und Hepatologie, Langenbeckstr. 1, D-55131, Mainz, Deutschland.

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November 2018

[Over-The-Scope-Clips: First Choice of Therapy for Recurrent Ulcer Bleeding?]

Z Gastroenterol 2018 11 12;56(11):1409-1411. Epub 2018 Nov 12.

Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster.

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November 2018

[Interpretation und performance of high-resolution esophageal manometry: Recommendations of the German Association of Neurogastroenterology and Motility (DGNM) and the German Association of Gastroenterology, Digestive and Metabolic Diseases (DGVS)].

Z Gastroenterol 2018 Nov 12;56(11):1378-1408. Epub 2018 Nov 12.

Medizinische Klinik und Poliklinik II, LMU, Campus Großhadern, München.

Esophageal manometry provides a detailed evaluation of esophageal contractility and, therefore, represents the reference method for diagnosis of esophageal motility disorders. Significance and clinical relevance have been further increased by implementation of high-resolution esophageal manometry (HRM), which reveals the functional anatomy of the esophagus in a visually-intuitive manner. The current 3 rd version of the international Chicago Classification (CC v3. Read More

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November 2018
2 Reads

[Advances in the diagnosis and treatment of Clostridioides [Clostridium] difficile infections in inflammatory bowel disease].

Z Gastroenterol 2018 Nov 12;56(11):1369-1377. Epub 2018 Nov 12.

Internistische Gemeinschaftspraxis für Verdauungs- und Stoffwechselkrankheiten, Leipzig und Schkeuditz.

Patients with chronic inflammatory bowel disease (IBD) have a significantly increased risk of clinically relevant clostridial infection (CDI). In turn, CDI can increase IBD activity. Therefore, rapid diagnosis and therapy is required. Read More

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November 2018
1 Read

[Endoscopic submucosal dissection for mucosal low-risk early gastric cancer - a retrospective, unicentric study].

Z Gastroenterol 2018 Nov 12;56(11):1343-1353. Epub 2018 Nov 12.

Institut für Pathologie Süd, Städtisches Klinikum München GmbH, Deutschland.

Background:  Endoscopic submucosal dissection (ESD) is the standard-procedure in Asia for the treatment of early gastric cancer (EGC) within defined criteria. In Europe, this technique is being used more and more frequently. In the context of risk constellations (submucosal invasion, lymphangioinvasion, poorly differentiated carcinoma), the occurrence of lymph node metastases is possible. Read More

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November 2018
2 Reads

Sensitivity and specifity of autoantibodies against CD74 in axial spondyloarthritis.

Arthritis Rheumatol 2018 Nov 12. Epub 2018 Nov 12.

Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover.

Objectives: Autoantibodies against CD74 (anti-CD74) are associated with ankylosing spondylitis. InterSpA is a multicenter study conducted to compare sensitivity and specificity of anti-CD74 and HLA-B27 in patients with non-radiographic axial spondyloarthritis (nr-axSpA).

Methods: Patients aged 18-45 years with inflammatory back pain of ≤2 years duration and clinical suspicion of axSpA were recruited. Read More

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November 2018
1 Read

Hepatic encephalopathy: Another brick in the wall.

J Hepatol 2018 Nov 7. Epub 2018 Nov 7.

Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France; Sorbonne Université, Brain Liver Pitié-Salpêtrière (BLIPS) Study Group, Assistance Publique - Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière-Charles Foix, Service d'Hépato-Gastroentérologie, Unité de Soins Intensifs d'Hépato-Gastroentérologie, Paris, France.

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November 2018
1 Read

Presenting signs and patient co-variables in Gaucher disease: outcome of the Gaucher Early Diagnosis Consensus (GED-C) Delphi initiative.

Intern Med J 2018 Nov 10. Epub 2018 Nov 10.

Shaare Zedek Medical Center and Hadassah Medical School, Jerusalem, Israel.

Background: Gaucher disease (GD) presents with a range of signs and symptoms. Physicians can fail to recognize the early stages of GD owing to a lack of disease awareness, which can lead to significant diagnostic delays and sometimes irreversible but avoidable morbidities.

Aims: The Gaucher Earlier Diagnosis Consensus (GED-C) initiative aimed to identify signs and co-variables considered most indicative of early type 1 and type 3 GD, to help non-specialists identify 'at-risk' patients who may benefit from diagnostic testing. Read More

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November 2018
13 Reads

European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale.

Contemp Clin Trials 2018 Dec 5;75:67-71. Epub 2018 Nov 5.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom; Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom.

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in children and has the potential to progress to advanced fibrosis/cirrhosis, end-stage liver disease and hepatocellular carcinoma. However, the natural history of the condition is poorly understood and there are no approved treatments. The European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD) is a multi-centre registry of paediatric NAFLD that will serve as a prospective, observational, natural history study and provide a tractable back-bone to support recruitment into subsequent interventional trials. Read More

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December 2018
5 Reads

De Novo Primary Liver Cancer After Liver Transplantation: A French National Study on 15803 Patients.

Exp Clin Transplant 2018 12 6;16(6):779-780. Epub 2018 Nov 6.

From the Hôpital Côte de Nacre, Service d'Hépato-Gastroentérologie, Nutrition et Oncologie Digestive, Caen, France; and the Unité Inserm-U1149, Centre de recherche sur l'inflammation, Paris, France.

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December 2018
5 Reads

European Association for the Study of the Liver and French hepatitis C recent guidelines: The paradigm shift.

World J Hepatol 2018 Oct;10(10):639-644

Fédération d'Hépatologie, Service d'Hépato-gastroentérologie, CHU Limoges, Limoges 87042, France.

The latest Association Française pour l'Etude du Foie - French Association for Study of the Liver (AFEF) and European Association for the Study of the Liver (EASL) recommendations announce a change of paradigm, for the management of patients infected with hepatitis C virus (HCV). The AFEF recommendations focus on the elimination of HCV infection on a national level by preventing reinfection, in less than ten years. This goal involves the facilitation of patients' management in a simplified pathway by increasing screening procedures and access to pangenotypic treatments mainly in the "reservoir" population of people who inject drugs and migrants. Read More

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October 2018
2 Reads

[Obscure gastrointestinal bleeding: The role of SPECT/CT hybrid imagin].

Presse Med 2018 Nov - Dec;47(11-12 Pt 1):1010-1013. Epub 2018 Oct 29.

CHU Mohammed VI-Marrakech, service de gastroentérologie, Marrakech, Maroc.

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October 2018

Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma.

Viruses 2018 Oct 30;10(11). Epub 2018 Oct 30.

Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), 69003 Lyon, France.

Hepatitis C virus (HCV) infection is a worldwide health problem and is one of the main causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Despite recent improvements, effective treatments for HCC are still missing and new tools for early detection are needed. Non-coding RNAs (ncRNAs) have emerged as important regulators of gene expression and key players in human carcinogenesis, including HCC. Read More

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October 2018
3 Reads

[Special situations of preconditioning and prehabilitation in oncological visceral surgery].

Chirurg 2018 Nov;89(11):903-908

Abteilung Sportmedizin, Prävention und Rehabilitation am Institut für Sportwissenschaft, Johannes Gutenberg-Universität Mainz, Mainz, Deutschland.

Background: Prehabilitation prior to complex visceral oncological surgery is playing an increasingly important role.

Objective: The aim of this review article is to present special situations of preconditioning in visceral oncological patient cohorts. The following conditions were defined as special situations with subsequently increased risk profile: cardiopulmonary comorbidities, geriatric patients, neoadjuvant therapy and simultaneous fatigue. Read More

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November 2018
7 Reads