7,987 results match your criteria Gastroenterologie Clinique et Biologique [Journal]


[Treatment has a positive impact on the long-term evolution of chronic hepatitis B].

Authors:
P Marcellin

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S99-102

Service d'Hépatologie, Centre de Recherche INSERM CRB3, Hôpital Beaujon, Clichy, France.

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http://dx.doi.org/10.1016/S0399-8320(10)70027-0DOI Listing
September 2010
6 Reads

[Treatment of chronic hepatitis B: adherence and safety].

Authors:
S Pol P Sogni

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S142-8

Unité d'Hépatologie, Inserm U-567 et Université Paris V (René Descartes), Hôpital Cochin, Paris, France.

Second generation nucleos (t) idic analogues result in a complete viral suppression after 48 to 96 weeks of therapy in most patients, regardless of the virus (HBV genotype, wild type or pre-C mutant), the underlying liver disease (cirrhosis or not) or the immune status (mono- or HIV/HBV co-infection). This antiviral efficacy may result in HBe or HBs seroconversion. Its clinical impact is important since inactivation of necroinflammation allows, in the absence of liver comorbidities, a stabilisation then a reversal of fibrosis and cirrhosis, and consequently a decrease in the occurrence of carcinomatous or non-carcinomatous complications. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70034-8DOI Listing
September 2010
4 Reads

[Long-term therapy for chronic hepatitis B in HIV co-infected patients].

Authors:
R Pais Y Benhamou

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S136-41

Service d'Hépato-Gastroentérologie, Hôpital Pitié-Salpêtrière, Paris, France.

As human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are acquired through the same routes of contamination, the prevalence of HBV serological markers found in the HIV-infected population is approximately 7%. Liver-related mortality and morbidity is higher in HIV/HBV co-infected patients than in HBV mono-infected patients. Both viruses must be considered before a treatment decision is made. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70033-6DOI Listing
September 2010
7 Reads

[Analogs combination therapy in chronic hepatitis B: when and how?].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S126-35

Service d'Hépato-gastroentérologie Hôpital Saint Joseph, Marseille, France.

Hepatitis B virus (HBV) genomic variability is responsible for the complexity of the viral quasi-species and its evolution during the course of infection. The persistence of infected cells promotes the selection of drug-resistant strains. The development of nucleoside analogs without cross-resistance has provided a rationale for combination therapy. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70032-4DOI Listing
September 2010
5 Reads

[HBsAg seroclearance: prognostic value for the response to treatment and the long-term outcome].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S119-25

Service d'Hépatologie et INSERM U773-CRB3, Hôpital Beaujon, Clichy, France.

Chronic hepatitis B is a major cause of liver disease worldwide, ranking as the first cause of cirrhosis and hepatocellular carcinoma. Hepatitis B surface antigen (HBsAg) is usually used as a qualitative marker for the diagnosis of hepatitis B virus (HBV) infection. HBsAg clearance is the closest to cure outcome as one can expect to achieve in hepatitis B. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70031-2DOI Listing
September 2010
4 Reads

[HBsAg quantification: virological significance].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S112-8

Hospices Civils de Lyon, Hôtel Dieu, Service d'hépatologie et de gastroentérologie, Lyon, France.

HBsAg is a classic marker of hepatitis B virus infection. Since the levels of serum HBsAg are correlated to those of intrahepatic cccDNA, HBsAg quantification indirectly reflects the number of infected hepatocytes. The kinetics of serum HBsAg decline seems to be a predictive marker for sustained virological response, and clearance of HBsAg. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70030-0DOI Listing
September 2010
4 Reads

[Influence of treatment on long-term evolution of chronic hepatitis B].

Authors:
J-P Zarski

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S109-11

Clinique Universitaire d'Hépato-Gastroentérologie, Unité INSERM/UJF U823 IAPC Institut Albert Bonniot, CHU de Grenoble, Grenoble, France.

The treatment of chronic hepatitis B is essentially based on the use of nucleoside or nucleotide analogues, which lead to viral suppression in the majority of cases. Viral suppression is associated with normal ALT values and progressive histological improvement of not only necroinflammatory lesions but also fibrosis. Regression of cirrhosis can be observed in severe cases. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70029-4DOI Listing
September 2010
5 Reads

[Liver fibrosis in hepatitis B: a dynamic process].

Authors:
P Bedossa

Gastroenterol Clin Biol 2010 Sep;34 Suppl 2:S103-8

Service d'Anatomie pathologique, Hôpital Beaujon, Clichy, France.

Liver fibrosis is a common complication of chronic hepatitis B leading to the progressive destruction of normal tissue architecture or the replacement of hepatocytic tissue with fibrous tissue. The final outcome of this process is liver cirrhosis, which is the major cause of morbidity and mortality in chronic viral hepatitis. Fibrogenesis is closely related to activation of the main type of fibrocompetent cells in the liver: hepatic stellate cells. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70028-2DOI Listing
September 2010
5 Reads

Feasibility and safety of granulocytapheresis in Crohn's disease: a prospective cohort study.

Gastroenterol Clin Biol 2010 Dec 13;34(12):682-6. Epub 2010 Nov 13.

U.O. di Gastroenterologia e Malattie Ricambio, Azienda Ospedaliera-Universitaria Pisana, A. Della Spina, 11, 56124 Pisa, Italy.

Background And Objective: This study evaluated the feasibility and safety of granulocytapheresis (GCAP) in inducing and maintaining remission in refractory Crohn's disease. The relationship between the clinical outcomes and the location (ileal or ileocolonic) of disease was also assessed.

Patients: We evaluated 16 patients with ileal location (group A), 14 with ileocolonic location (group B). Read More

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http://dx.doi.org/10.1016/j.gcb.2010.09.009DOI Listing
December 2010
4 Reads

Expected increase in prevalence of HCV-related cirrhosis and its complications in the United States: no effect of current antiviral treatment coverage?

Authors:
S Deuffic-Burban

Gastroenterol Clin Biol 2010 Nov 3;34(11):577-9. Epub 2010 Nov 3.

Inserm U995, Amphi J&K, boulevard du Professeur-Jules-Leclercq, 59045 Lille, France.

Davis et al. projected the future prevalence of chronic hepatitis C (CHC) and its complications in the United States, using a multicohort natural history model with a tree model. First, the model predicted that in 2010 many patients have already progressed to F4, including to decompensated cirrhosis and HCC. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.09.004DOI Listing
November 2010
3 Reads

Stem cells and colon cancer: the questionable cancer stem cell hypothesis.

Authors:
C Gespach

Gastroenterol Clin Biol 2010 Dec 3;34(12):653-61. Epub 2010 Nov 3.

Inserm U938, centre de recherche Saint-Antoine, hôpital Saint-Antoine, bâtiment Kourisky, 75571 Paris cedex 12, France.

The fine-tuning between cell proliferation and differentiation of self-renewing stem cells and pluripotent progenitors in gastric glands and colon epithelial crypts is coordinated by the mechanisms that regulate colon epithelial cell migration and guidance along the crypt axis. This leads to the acquisition of specialized cellular functions and the exfoliation of desquamated senescent and apoptotic epithelial cells at the apical mucosa interface with the gut lumen. Self-renewing stem cells and pluripotent progenitors are involved in the clonal and polyclonal growth of digestive tumors. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.014DOI Listing
December 2010
3 Reads

The emerging role of internal rectal prolapse in the aetiology of faecal incontinence.

Gastroenterol Clin Biol 2010 Nov 3;34(11):584-6. Epub 2010 Nov 3.

Pelvic Floor Service, Dept of Colorectal Surgery, Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.gcb.2010.09.007DOI Listing
November 2010
5 Reads

Images of the month. Unusual left iliac fossa pain.

Gastroenterol Clin Biol 2010 Nov 2;34(11):575-6. Epub 2010 Nov 2.

All India Institute of Medical Sciences, Department of Radiology, Ansari Nagar, New Delhi, India.

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http://dx.doi.org/10.1016/j.gcb.2010.07.010DOI Listing
November 2010
6 Reads

Enteropathy-associated T-cell lymphoma: a review on clinical presentation, diagnosis, therapeutic strategies and perspectives.

Gastroenterol Clin Biol 2010 Nov 2;34(11):590-605. Epub 2010 Nov 2.

Service d'hématologie adulte, hôpital Necker-Enfants-Malades, Assistance publique-Hôpitaux de Paris, université Paris V-René-Descartes, 149, rue de Sèvres, 75743 Paris cedex 15, France.

Introduction: Enteropathy-associated T-cell lymphoma (EATL) is a rare complication of celiac disease (<1% of lymphomas) and has a poor prognosis.

Methods: International literature review with PubMed search (up to January 2009) of pathophysiological, clinical and therapeutic data.

Results: EATL is found in patients with a mean age of 59 years, often with a complication that signals its diagnosis. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.09.008DOI Listing
November 2010
20 Reads

Image of the month. Hepatic visceral larva migrans due to Toxocara Canis.

Gastroenterol Clin Biol 2010 Nov 30;34(11):573-4. Epub 2010 Oct 30.

Department of Radio-diagnosis, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1016/j.gcb.2010.07.012DOI Listing
November 2010
5 Reads

Polycythemia and elevated serum erythropoietin associated with a liver haemangioma.

Gastroenterol Clin Biol 2010 Nov 25;34(11):629-32. Epub 2010 Oct 25.

Fédération des spécialités digestives, hôpital Édouard-Herriot, hospices civils de Lyon, pavillon Hbis, 69437 Lyon cedex 03, France.

Background: Secondary polycythemia is a rare condition, which is usually associated to neoplasia or chronic pulmonary disorders.

Case Report: A 41-year-old man man with no history of liver disease was admitted for erythrocytosis. The paraclinical investigations revealed an increased erythropoietin level in the serum and a voluminous hepatic tumor but its identification was unclear. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.013DOI Listing
November 2010
8 Reads

Therapeutic apheresis from the early civilizations to the twenty-first century.

Gastroenterol Clin Biol 2010 Dec 23;34(12):645-8. Epub 2010 Oct 23.

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http://dx.doi.org/10.1016/j.gcb.2010.09.003DOI Listing
December 2010
4 Reads

Colonoscopy practices, and colorectal cancer and polyp screening, as assessed in the French district of Isère from May to July in 2004.

Gastroenterol Clin Biol 2010 Dec 20;34(12):702-11. Epub 2010 Oct 20.

ODLC, BP 139, 38244 Meylan cedex, France.

Background: A pilot program of organized screening for colorectal cancers was conducted in Isère, an administrative district in France. A fecal occult blood test (Hemoccult II(®)) was proposed for all individuals aged greater than 50 years (women since 1991 and men since 2002), followed by colonoscopy for those testing positive. A prospective study was carried out from May to July in 2004 and compared with a similar study conducted in 1996. Read More

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http://dx.doi.org/10.1016/j.gcb.2009.09.008DOI Listing
December 2010
5 Reads

Sir James Black (1924-2010), β-blockers and liver disease.

Authors:
S Erlinger

Gastroenterol Clin Biol 2010 Oct 12;34(10):513-5. Epub 2010 Oct 12.

University of Paris 7, France.

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http://dx.doi.org/10.1016/j.gcb.2010.05.009DOI Listing
October 2010
5 Reads

Transcatheter local thrombolysis in patients with extensive TIPS thrombosis.

Gastroenterol Clin Biol 2010 Dec 12;34(12):721-5. Epub 2010 Oct 12.

Fédération des spécialités digestives, Hospices civils de Lyon, hôpital Édouard-Herriot, pavillon Hbis, 69437 Lyon cedex 03, France.

Background: Transcatheter local thrombolytic therapy in patients with portosplanchnic venous thrombosis has been used in few cases.

Case Reports: Here, we present our single-center experience with transcatheter thrombolytic therapy in three patients with extensive refractory portal and transjugular intrahepatic portosystemic shunt (TIPS) thrombosis. Thrombolytic therapy was successful for all three patients. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.07.011DOI Listing
December 2010
12 Reads

Association of Budd-Chiari syndrome and celiac disease.

Gastroenterol Clin Biol 2010 Nov 8;34(11):621-4. Epub 2010 Oct 8.

Service d'hépato-gastroentérologie, CHU Mustapha, Alger, Algeria.

Background And Aims: An association between Budd-Chiari syndrome (BCS) and celiac disease (CD) is uncommon. The aims of our study were to investigate the etiology of BCS and to search for a particular HLA Ag pattern among patients.

Patients And Methods: BCS diagnosis was based on Doppler ultrasound and CD diagnosis on duodenal biopsy, transglutaminase (TGAb) and gliadin antibodies (GAb). Read More

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http://dx.doi.org/10.1016/j.gcb.2010.07.007DOI Listing
November 2010
5 Reads

Functional comparisons between open and laparoscopic rectopexy.

Authors:
S R Smith M Solomon

Gastroenterol Clin Biol 2010 Oct 12;34(10):505-7. Epub 2010 Oct 12.

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http://dx.doi.org/10.1016/j.gcb.2010.08.003DOI Listing
October 2010
5 Reads

Clinical and endoscopic features of responders and non-responders to adsorptive leucocytapheresis: a report based on 120 patients with active ulcerative colitis.

Gastroenterol Clin Biol 2010 Dec 8;34(12):687-95. Epub 2010 Oct 8.

Department of Internal Medicine, Chugoku Rosai Hospital, Hirotagaya 1-5-1, Kure, Hiroshima 737-0193, Japan.

Background And Objective: Elevated/activated myeloid leucocytes, like the CD14(+)CD16(+) monocytes are sources of TNF-α, and therefore, selective depletion of these cells by granulocyte/monocyte (GM) adsorption (GMA) should promote remission or enhance drug efficacy. However, studies in ulcerative colitis (UC) reported contrasting efficacy, from an 85% to statistically insignificant level. We investigated patients' demography in responders and non-responders. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.007DOI Listing
December 2010
9 Reads

An exceptional case of internal transomental hernia: correlation between CT and surgical findings.

Gastroenterol Clin Biol 2010 Oct 8;34(10):562-4. Epub 2010 Oct 8.

Department of Radiology, hôpital d'instruction des armées Desgenettes, 108 boulevard Pinel, Lyon, France.

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http://dx.doi.org/10.1016/j.gcb.2010.04.013DOI Listing
October 2010
3 Reads

The HAMLET case: what can we learn from a misfolded protein that triggers tumour cell death?

Authors:
A Lamazière C Wolf

Gastroenterol Clin Biol 2010 Nov 8;34(11):580-3. Epub 2010 Oct 8.

Faculté de médecine, UPMC, Applied Lipidomics Ingestigation, 27, rue Chaligny, 75012 Paris, France.

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http://dx.doi.org/10.1016/j.gcb.2010.08.012DOI Listing
November 2010
4 Reads

IL28B polymorphisms and chronic hepatitis C.

Gastroenterol Clin Biol 2010 Nov;34(11):587-9

French National Reference Center for Viral Hepatitis B, C and delta, Department of Virology, hôpital Henri-Mondor, université Paris-Est Créteil, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.

Human genetic factors that influence HCV treatment responses have been identified by a recent landmark discovery. A SNP has been identified (rs12979860) located in chromosome 19,3 kb upstream of the IL28B gene that encodes IFN-λ3, which was strongly associated with the sustained virological response (SVR) to pegIFN and ribavirin in more than 1000 patients with genotype 1 chronic hepatitis C. In patients of European ancestry, as well as in African-American and Hispanic patients, the CC genotype was associated with a two-fold greater SVR rate than the TT genotype, CT being closer to TT than to CC. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.06.008DOI Listing
November 2010
4 Reads

[The clinical importance of intestinal microbiota].

Authors:
P Marteau

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S93-7

Medical-Surgical Digestive Pathology Department, Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, Paris, France.

Clinicians have long learned of the pathogenic microorganisms that cause intestinal infections and that can be identified by culture methods from fecal, mucosa and blood samples. Nevertheless, much progress has been made due, in large part, to molecular biology which has enabled the discovery of pathogens that are not (yet) able to be cultured, but also to the protective role of some microorganisms within the microbiota. Ecological and clinical disturbances related to antibiotic therapy were decisive for demonstrating the beneficial effects of the endogenous microbiota and establishing the beneficial effects of biotherapeutic agents, known as probiotics. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70026-9DOI Listing
September 2010
4 Reads

[Functional biostructure of colonic microbiota (central fermenting area, germinal stock area and separating mucus layer) in healthy subjects and patients with diarrhea treated with Saccharomyces boulardii].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S79-92

Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms and Department of Medicine, Section of Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany.

The colonic content can be compared to a spatially structured high output bioreactor composed of three functionally different regions: a separating mucus layer, a germinal stock area, and a central fermenting area. The stool mirrors this structure and can be used for diagnosis in health and disease. In a first part, we introduce a novel method based on fluorescence in situ hybridization (FISH) of sections of punched-out stool cylinders, which allows quantitatively monitor microbiota in the mucus, the germinal stock and the central fermenting areas. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70025-7DOI Listing
September 2010
7 Reads

[Saccharomyces boulardii modulates dendritic cell properties and intestinal microbiota disruption after antibiotic treatment].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S71-8

EA 4043, USC INRA Ecosystème Microbien Digestif et Santé, Pharmacy Faculty, Paris-Sud-XI University, Châtenay-Malabry Cedex, France.

Saccharomyces boulardii is a non-pathogenic yeast with biotherapeutic properties that has been used successfully to prevent and to treat various infectious and antibiotic-associated diarrheas. The intestinal microbiota is responsible for colonization resistance and immune response to pathogens but can be disrupted by antibiotics and lose its barrier effect. Dendritic cells (DCs) are professional antigen-presenting cells of the immune system with the ability to initiate a primary immune response or immune tolerance. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70024-5DOI Listing
September 2010
5 Reads

[The human intestinal microbiota].

Authors:
J Doré G Corthier

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S7-15

Institut National de la Recherche Agronomique, MICALIS ex-UEPSD, Domaine de Vilvert, 78350 Jouy-en-Josas, France.

The human intestinal microbiota constitutes a complex ecosystem which is now well recognized for its impact on human health and well-being. It contributes to maturation of the immune system and provides a direct barrier against colonization by pathogens. Its possible implication in diseases of modern societies, currently increasing in prevalence, has been reported. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70015-4DOI Listing
September 2010
5 Reads

[Recent advances in Saccharomyces boulardii research].

Authors:
E Im C Pothoulakis

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S62-70

Section of Inflammatory Bowel Disease and Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, United States.

This review summarizes the probiotic mechanisms of action of Saccharomyces boulardii (S. boulardii) against inflammatory and non-inflammatory diarrheal conditions. S. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70023-3DOI Listing
September 2010
4 Reads

[Microbiota and enteral nutrition].

Authors:
S-M Schneider

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S57-61

Division of Digestive Diseases, University Hospital of Nice, France.

Enteral nutrition is a nutritional therapy that is used in up to 10% of hospitalized patients. It involves a dramatic change in the provision of nutrients to the intestine and this, along with metabolic stress and drugs used, is responsible for a marked dysbiosis. Even though there is a huge level of between-subject variability, this dysbiosis is characterized by a decrease in the dominant flora, an increase in potentially pathogenic microorganisms and a reduction in the number of individual strains. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70022-1DOI Listing
September 2010
4 Reads

[Microbiota and irritable bowel syndrome].

Authors:
P Ducrotté

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S52-6

ADEN EA 4311/IFRMP 23, Department of Hepatogastroenterology and Nutrition, Regional University Hospital, Charles Nicolle Hospital, 1 Rue de Germont, Rouen Cedex, France.

Irritable bowel syndrome (IBS) is a multifactorial disease during which the pathophysiological role of the gut microbiota has been recently highlighted. In almost 20% of the patients, IBS is clearly a post-infectious IBS as a consequence of an acute bacterial gastroenteritis. Some papers have reported an abnormal colonic fermentation in IBS patients that could explain symptoms such as bloating and be one of the factors triggering visceral hypersensitivity. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70021-XDOI Listing
September 2010
5 Reads

[Gut microbiota and IBD].

Authors:
P Seksik

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S44-51

Gastroenterology and Nutrition Department, Hôpital Saint Antoine, AP-HP, Paris, France.

Gut microbiota contains about 10(14) bacterial cells classified within 4 bacterial phyla, namely Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria. Much of the information has been generated through the application of nucleic acid-based methodologies (16S rRNA) which provide a cornerstone of microbial taxonomy. Inflammatory bowel disease (IBD) involves a dysregulated immune response to the gut microbiota in genetically predisposed hosts. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70020-8DOI Listing
September 2010
4 Reads

[Intestinal microbiota in short bowel syndrome].

Authors:
O Goulet F Joly

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S37-43

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Necker-Enfants Malades, University of Paris-Descartes, Paris, France.

Short bowel syndrome (SBS) is the main cause of intestinal failure especially in children. The colon is a crucial partner for small intestine adaptation and function in patients who have undergone extensive small bowel resection. However, SBS predisposes the patient to small intestine bacterial overgrowth (SIBO), explaining its high prevalence in patients with this disorder. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70019-1DOI Listing
September 2010
5 Reads

[The microbiota and infectious diarrhea].

Authors:
C-M Surawicz

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S29-36

University of Washington School of Medicine, 325 9th Avenue, Seattle, WA 98104, USA.

Understanding the importance of the fecal microbiota has been key in understanding the pathophysiology of some infectious diarrheas. In addition to normal protective measures of bile, gastric acid, and immune response, among others, we now know that the healthy gut flora protects us from some infectious diarrheas. Antibiotic associated diarrhea (AAD) is an excellent example, as antibiotics perturb the normal flora; the resulting diarrhea may be due to changes in short chain fatty acid metabolism. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70018-XDOI Listing
September 2010
4 Reads

[Metagenomics of the intestinal microbiota: potential applications].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S23-8

Institut National de la Recherche Agronomique, MetaHIT coordinator, Microbiology and the Food Chain Division, Jouy-en-Josas, France.

A major challenge in the human metagenomics field is to identify associations of the bacterial genes and human phenotypes and act to modulate microbial populations in order to improve human health and wellbeing. MetaHIT project addresses this ambitious challenge by developing and integrating a number of necessary approaches within the context of the gut microbiome. Among the first results is the establishment of a broad catalog of the human gut microbial genes, which was achieved by an original application of the new generation sequencing technology. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70017-8DOI Listing
September 2010
4 Reads

[Fermentative metabolism by the human gut microbiota].

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S16-22

UR454 Microbiology Division, INRA, Research Centre of Clermont-Ferrand-Theix, 63 122 Saint Genès-Champanelle, France.

The human large intestine is colonized by a complex community of microorganisms, largely composed of strictly anaerobic bacteria with numerous physiological functions which impact on the host nutrition and health. Among these functions, the fermentation of substrates is of major importance for host health through the production of a wide variety of metabolites. The metabolic functions of the human gut microbiota are correlated with the nature of the substrates available for fermentation in the colon. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70016-6DOI Listing
September 2010
4 Reads

[A new era in gut research concerning interactions between microbiota and human health].

Authors:
G Corthier J Doré

Gastroenterol Clin Biol 2010 Sep;34 Suppl 1:S1-6

Institut National de la Recherche Agronomique, MICALIS ex-UEPSD, Domaine de Vilvert, 78350 Jouy-en-Josas, France.

The scope of this introduction is to make a small review of the texts presented here and to emphasize some points that are not developed but that concern human microbiota functions. Read More

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http://dx.doi.org/10.1016/S0399-8320(10)70014-2DOI Listing
September 2010
5 Reads

Multiple intestinal perforation in a patient with Wegener's granulomatosis: a case report and review of the literature.

Gastroenterol Clin Biol 2010 Dec 29;34(12):712-5. Epub 2010 Sep 29.

Turkish Ministry of Health, Ankara Diskapi Education and Researching Hospital, Department of 2nd General Surgery, Diskapi, Ankara, Turkey.

Wegener's granulomatosis is a necrotizing vasculitis of unknown etiology characterized mainly by inflammation of the small- and medium-sized arteries and veins that affect any viscera. It may rarely involve the gastrointestinal tract. Only a few cases of multiple focus ileal perforation due to ulcers associated with Wegener's granulomatosis have been reported. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.009DOI Listing
December 2010
4 Reads

Nicorandil: a curable cause of anal ulceration to be known...

Gastroenterol Clin Biol 2010 Nov 29;34(11):639-40. Epub 2010 Sep 29.

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http://dx.doi.org/10.1016/j.gcb.2010.08.005DOI Listing
November 2010
18 Reads

Obesity, type 2 diabetes and risk of digestive cancer.

Gastroenterol Clin Biol 2010 Oct;34(10):529-33

Université de Bourgogne, CHU de Dijon, rue de l'église, Dijon, France.

The frequency of obesity has been increasing worldwide for 20 years. Many epidemiological studies support a correlation between obesity and increased risk of cancer, particularly digestive cancers in both genders, and gynaecological cancer in women. Currently, about 5% of cancers could be directly related to overweight. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.07.021DOI Listing
October 2010
5 Reads

A not so solitary fibrous tumor of the liver.

Gastroenterol Clin Biol 2010 Dec 22;34(12):716-20. Epub 2010 Sep 22.

Service d'hepato-gastroentérologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France.

Solitary fibrous tumor (SFT) is a rare neoplasm. Liver parenchyma is a rare location of SFT and, in this case, it usually follows a benign course. We report here the case of a 54-year-old man who presented a large SFT tumor of the right hepatic lobe. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.004DOI Listing
December 2010
4 Reads

Treatment of a nephrotic syndrome by endoscopic removal of a villous adenoma of the duodenum.

Gastroenterol Clin Biol 2010 Nov 17;34(11):625-8. Epub 2010 Sep 17.

Service de gériatrie, centre hospitalier régional de Citadelle, boulevard de 12e de ligne 1, 4000 Liège, Belgium.

We report the case of a patient diagnosed with a villous adenoma of the duodenum showing high degree dysplasia who developed a nephrotic syndrome (NS) due to a membranous nephropathy (MN), demonstrated by renal biopsy. Only the endoscopic resection of the duodenal adenoma could control the NS. The first manifestation of a MN is often the development of a NS. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.001DOI Listing
November 2010
4 Reads

A fulminant colitis index greater or equal to 8 is not predictive of colectomy risk in infliximab-treated moderate-to-severe ulcerative colitis attacks.

Gastroenterol Clin Biol 2010 Nov 15;34(11):612-7. Epub 2010 Sep 15.

Pôle reins-digestif-nutrition, service d'hépato-gastroentérologie et nutrition, CHU de Caen, BP 95182, 14033 Caen cedex 9, France.

Introduction: In severe attacks of ulcerative colitis (UC) treated with intravenous corticosteroids, a fulminant colitis index (FCI) greater or equal to 8 has been associated with a greater likelihood of colectomy (72 vs 16% with an FCI<8). This retrospective study aimed to assess the accuracy of such an association in infliximab-treated patients with moderate-to-severe bouts of UC.

Patients And Methods: The study was based on the medical files of 43 patients who had received at least one infusion of infliximab to treat moderate-to-severe UC (partial Mayo Clinic score). Read More

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http://dx.doi.org/10.1016/j.gcb.2010.07.013DOI Listing
November 2010
6 Reads

False bisalbuminemia and hyperalphafetoproteinemia.

Gastroenterol Clin Biol 2010 Nov 15;34(11):636-8. Epub 2010 Sep 15.

Laboratoire de biochimie et de toxicologie, hôpital universitaire de Monastir, 5000 Monastir, Tunisia.

The capillary electrophoresis is a very powerful separation method offering a high degree of resolution. However, certain interferences can be detected giving transitory shoulders or peaks. We report the case of a serum protein electrophoresis performed with Capillarys (Sebia) in a 68-year-old patient, hospitalized for cancer of the head of the pancreas, which showed an important shoulder in the migratory range of albumin, simulating bisalbuminemia. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.08.006DOI Listing
November 2010
4 Reads

Sociogeographical factors associated with participation in colorectal cancer screening.

Gastroenterol Clin Biol 2010 Oct 15;34(10):534-40. Epub 2010 Sep 15.

Association Arcades, parc Mure, 16 boulevard des Aciéries, Marseille cedex 10, France.

Background/aim: Sociodemographic factors associated with colorectal cancer screening participation have been extensively analysed although few, if any, studies have focused on regional/geographical factors as determinants of non-participation rates. The purpose of this study was to investigate the effects of individual and geographical determinants on the variable participation rates seen for colorectal cancer screening.

Methods: The study population comprised 183,978 individuals in the first round of screening and 175,596 in the second round, all of whom were residents of the city of Marseille in France. Read More

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http://dx.doi.org/10.1016/j.gcb.2010.06.007DOI Listing
October 2010
5 Reads

Circulating free tumor DNA and colorectal cancer.

Gastroenterol Clin Biol 2010 Dec 15;34(12):662-81. Epub 2010 Sep 15.

Université François-Rabelais, parc Grandmont, 37200 Tours, France. lecomt

Cancer is characterized by multiple somatic genetic and epigenetic alterations that could be useful as molecular markers for detecting tumor DNA in different bodily fluids. In patients with various diseases as well as in healthy subjects, circulating plasma and serum carry small amounts of non-cell-bound DNA. In this free circulating DNA, tumor-associated molecular alterations can be detected in patients who have cancer. Read More

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http://dx.doi.org/10.1016/j.gcb.2009.04.015DOI Listing
December 2010
4 Reads