11,602 results match your criteria Gastroenteritis Viral


[Norovirus nosocomial outbreak : an hospital experience].

Rev Med Liege 2019 Feb;74(2):86-89

Service de Microbiologie Clinique, CHU de Liège, Liège, Belgique.

Human noroviruses (NoV) are the main pathogenic agents worldwide responsible for viral sporadic and epidemic gastroenteritis worldwide. A gastroenteritis outbreak broke out in patients hospitalized in several wards located in two different floors of a hospital in Liege, Belgium. The objective was to determine whether a same NoV strain would be involved in the two different floors, and to explore how this outbreak would have spread from a floor to the other. Read More

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February 2019

GII.4 Human Norovirus: Surveying the Antigenic Landscape.

Viruses 2019 Feb 20;11(2). Epub 2019 Feb 20.

Department of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden, with 685 million infections reported annually. Vulnerable populations, such as children under the age of 5 years, the immunocompromised, and the elderly show a need for inducible immunity, as symptomatic dehydration and malnutrition can be lethal. Extensive antigenic diversity between genotypes and within the GII. Read More

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http://dx.doi.org/10.3390/v11020177DOI Listing
February 2019

Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy.

Viruses 2019 Feb 20;11(2). Epub 2019 Feb 20.

KU Leuven-Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven 3000, Belgium.

Viral gastroenteritis is an important cause of morbidity and mortality worldwide, being particularly severe for children under the age of five. The most common viral agents of gastroenteritis are noroviruses, rotaviruses, sapoviruses, astroviruses and adenoviruses, however, no specific antiviral treatment exists today against any of these pathogens. We here discuss the feasibility of developing a broad-spectrum antiviral treatment against these diarrhea-causing viruses. Read More

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http://dx.doi.org/10.3390/v11020173DOI Listing
February 2019

Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection.

Infect Genet Evol 2019 Feb 18. Epub 2019 Feb 18.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Avenida Brasil, 4365-Manguinhos, Rio de Janeiro, RJ, Brazil.

The Histo-blood group antigens (HBGA) are host genetic factors associated with susceptibility to rotavirus (RV) and human norovirus (HuNoV), the major etiological agents of viral acute gastroenteritis (AGE) worldwide. The FUT2 gene expressing the alpha-1, 2-L- fucosyltransferase enzyme is important for gut HBGA expression, and also provides a composition of the phenotypic profile achieved through mutations occurring in populations with different evolutionary histories; as such, it can be considered a genetic population marker. In this study, Lewis and secretor HBGA phenotyping was performed using 352 saliva samples collected from children between three months and five years old born in the Amazon (Brazil, Venezuela and English Guyana) presenting AGE or acute respiratory infection (ARI), the latter considered as control samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183091
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http://dx.doi.org/10.1016/j.meegid.2019.02.011DOI Listing
February 2019
1 Read

[Molecular epidemiology of norovirus in children with acute gastroenteritis in Tianjin, China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):139-143

Pediatric Research Institute, Tianjin Children's Hospital, Tianjin 300134, China.

Objective: To investigate the molecular epidemiological characteristics of norovirus (NoV) among children with acute gastroenteritis in Tianjin in 2017.

Methods: A total of 758 stool specimens were collected from the children with acute gastroenteritis possibly caused by viral infection in Tianjin Children's Hospital between January and December, 2017. Quantitative real-time RT-PCR was used for primary screening of NoV, and conventional RT-PCR was used for gene amplification, sequencing and genotype identification of the VP1 region of capsid protein in positive specimens. Read More

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February 2019
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Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication.

J Biol Chem 2019 Feb 15. Epub 2019 Feb 15.

Stanford University, United States.

Genome replication and virion assembly of segmented RNA viruses are highly coordinated events, tightly regulated by sequence and structural elements in the UTRs of viral RNA. This process is poorly defined and likely requires the participation of host proteins in concert with viral proteins. In this study, we employed a proteomics-based approach, named RNA-protein interaction detection (RaPID), to comprehensively screen for host proteins that bind to a conserved motif within the rotavirus (RV) 3' terminus. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006004DOI Listing
February 2019
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Reduction of hospitalizations with diarrhea among children aged 0-5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine.

Vaccine 2019 Mar 11;37(11):1407-1411. Epub 2019 Feb 11.

Unity of Gastroenteritis, Department of Virology, National Institute of Hygiene, Rabat, Morocco.

Introduction: Rotavirus vaccine was introduced in Mauritania in December 2014. We investigated hospitalizations with diarrhea during pre and post-vaccination periods among children aged 0-5 years in Nouakchott, the capital of Mauritania.

Methods: We conducted a retrospective review of hospital admission registries from November 1st 2012 through October 31th 2017 at all referral hospitals in Nouakchott. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.078DOI Listing

Intrahost viral evolution during chronic sapovirus infections.

J Clin Virol 2019 Feb 7;113:1-7. Epub 2019 Feb 7.

Institute of Virology, Leipzig University, Leipzig, Germany Johannisallee 30, 04103, Leipzig, Germany.

Background: Sapovirus is a common cause of self-limiting diarrhea. In immunocompromised individuals chronic infections occur, but are incompletely investigated.

Objectives: To investigate viral evolution in immunocompromised hosts during chronic sapovirus infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193002
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http://dx.doi.org/10.1016/j.jcv.2019.02.001DOI Listing
February 2019
2 Reads

G1P[8] Rotavirus in children with severe diarrhea in the post-vaccine introduction era in Brazil: Evidence of reassortments and structural modifications of the antigenic VP7 and VP4 regions.

Infect Genet Evol 2019 Feb 11;69:255-266. Epub 2019 Feb 11.

Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brazil. Electronic address:

Worldwide rotaviruses A (RVA) are responsible for approximately 215,000 deaths annually among children aged <5 years. RVA G1P[8] remains associated with >50% of gastroenteritis cases in this age group. The aim of this study was to assess the genetic variability of G1P[8] strains detected in children with severe diarrhea in Belém, Pará, Brazil, during the post-rotavirus vaccine introduction era. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.009DOI Listing
February 2019

Comparative Evaluation of Seegene Allplex Gastrointestinal, Luminex xTAG Gastrointestinal Pathogen Panel, and BD MAX Enteric Assays for Detection of Gastrointestinal Pathogens in Clinical Stool Specimens.

Arch Pathol Lab Med 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea (Drs Yoo, J. Park, H. K. Lee, and Y.-J. Park); the Department of Laboratory Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea (Mss Yu and K. G. Park and Mr G. D. Lee); and the Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge (Ms Oak).

Context.—: Infectious gastroenteritis is caused by various pathogens, including bacteria, viruses, and parasites.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0002-OADOI Listing
February 2019
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Human Sapovirus among Outpatients with Acute Gastroenteritis in Spain: A One-Year Study.

Viruses 2019 Feb 8;11(2). Epub 2019 Feb 8.

Department of Microbiology and Parasitology, CIBUS-Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Viral agents of human gastroenteritis affect people of all ages across the globe. As a mainly self-limiting disease, it is difficult to evaluate the real prevalence of etiological agents circulating in each region. Many of the analyzed outbreaks are caused by viruses of the family Caliciviridae, especially the genus (NoV). Read More

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http://dx.doi.org/10.3390/v11020144DOI Listing
February 2019

Prevalence, levels and seasonal variations of human enteric viruses in six major rivers in Alberta, Canada.

Water Res 2019 Apr 1;153:349-356. Epub 2019 Feb 1.

Department of Paediatrics, University of Alberta, 1405-87 Ave, Edmonton, AB, T6G 1C9, Canada.

The prevalence and seasonal variation of 7 viruses in 6 major rivers in Alberta were assessed using a combination of qPCR, cell culture and integrated cell culture with qPCR (ICC-qPCR). Water samples were collected monthly from rivers at different sites upstream and downstream of major urban centers. Seven viruses including rotavirus, adenovirus, astrovirus, norovirus, sapovirus, JC virus and enterovirus, were detected in at least one of the water samples at each site using qPCR. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.034DOI Listing
April 2019
1 Read

Impact of long-term storage of clinical samples collected from 1996 to 2017 on RT-PCR detection of norovirus.

J Virol Methods 2019 Feb 5. Epub 2019 Feb 5.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, Georgia, 30333, USA. Electronic address:

Noroviruses are recognized as the leading cause of acute gastroenteritis globally. With improved molecular diagnostics developed over the last two decades, archived clinical specimens are increasingly used to investigate the historic prevalence and molecular epidemiology of human norovirus. Yet the impact of long-term storage on viral integrity in clinical specimens has not been evaluated. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.02.001DOI Listing
February 2019
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Molecular epidemiology and host genetics of norovirus and rotavirus infections in Portuguese elderly living in aged care homes.

J Med Virol 2019 Feb 8. Epub 2019 Feb 8.

Unidade de Microbiologia Médica, Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Lisboa, Portugal.

Norovirus (NoV) and rotavirus group A (RVA) are major agents of acute gastroenteritis worldwide. This study aimed to investigate their epidemiological profile in Portuguese elderly living in long-term care facilities and to assess the host genetic factors mediating infection susceptibility. From November 2013 to June 2015, 636 faecal specimens from 169 elderly, mainly asymptomatic, living in nursing homes in Greater Lisbon and Faro district, Portugal, were collected. Read More

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http://dx.doi.org/10.1002/jmv.25425DOI Listing
February 2019
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Construction and characterization of porcine single-chain fragment variable antibodies that neutralize transmissible gastroenteritis virus in vitro.

Arch Virol 2019 Feb 7. Epub 2019 Feb 7.

Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai JiaoTong University, Shanghai, 200240, People's Republic of China.

Transmissible gastroenteritis virus (TGEV) infection causes severe diarrhea in piglets and imposes a significant economic burden on pig farms. Single-chain fragment variable (scFv) antibodies effectively inhibit virus infection and could be a potential therapeutic reagent for preventing disease. In this study, a recombinant scFv antibody phage display library was constructed from peripheral blood lymphocytes of piglets infected with TGEV. Read More

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http://dx.doi.org/10.1007/s00705-019-04156-6DOI Listing
February 2019
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Genetic Analysis of an Emerging GII.P2-GII.2 Norovirus Associated with a 2016 Outbreak of Acute Gastroenteritis in China.

Virol Sin 2019 Feb 6. Epub 2019 Feb 6.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-019-00084-6DOI Listing
February 2019

Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus.

Arch Virol 2019 Feb 6. Epub 2019 Feb 6.

Molecular Virology Laboratory, Federal Research Center for Virology and Microbiology, Academician Bakoulova Street, 1, Petushki Area, Volginsky, Vladimir Region, 601125, Russia.

Porcine epidemic diarrhea (PED) is a contagious viral disease in pigs, caused by the coronavirus porcine epidemic diarrhea virus (PEDV). PEDV infection results in significant mortality in piglets in unvaccinated herds. Like many others RNA viruses, PEDV has high evolutionary rate and is prone to genetic mutations. Read More

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http://dx.doi.org/10.1007/s00705-019-04166-4DOI Listing
February 2019

Differentiating Acute Food Protein-Induced Enterocolitis Syndrome From Its Mimics: A Comparison of Clinical Features and Routine Laboratory Biomarkers.

J Allergy Clin Immunol Pract 2019 Feb 25;7(2):471-478.e3. Epub 2018 Oct 25.

Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Background: Food protein-induced enterocolitis syndrome (FPIES) is frequently misdiagnosed and subject to diagnostic delay. Profuse vomiting, the cardinal feature of acute FPIES, may occur in more common pediatric disorders such as gastroenteritis and sepsis.

Objectives: We sought to determine differentiating features at acute presentation between FPIES, gastroenteritis, and sepsis in young children presenting to an emergency department (ED) with profuse vomiting. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.10.020DOI Listing
February 2019
4 Reads

Synchronized Orchestration of miR-99b and let-7g Positively Regulates Rotavirus Infection by Modulating Autophagy.

Sci Rep 2019 Feb 4;9(1):1318. Epub 2019 Feb 4.

Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata, WB, India.

Rotavirus (RV), the major etiological agent of viral gastroenteritis in young children, kills over 200 thousand infants each year. In spite of available vaccines, rotaviral diarrhoea is still a major problem in developing countries of Asia and Africa. Therefore, the studies on RV infection and host antiviral responses are warranted. Read More

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http://dx.doi.org/10.1038/s41598-018-38473-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362297PMC
February 2019
1 Read
5.078 Impact Factor

Development and Evaluation of a Multiplexed Immunoassay for Simultaneous Detection of Serum IgG Antibodies to Six Human Coronaviruses.

Sci Rep 2019 Feb 4;9(1):1390. Epub 2019 Feb 4.

National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention 1600 Clifton Rd NE, Atlanta, GA, 30329, USA.

Known human coronaviruses (hCoV) usually cause mild to moderate upper-respiratory tract illnesses, except SARS-CoV and MERS-CoV, which, in addition to mild illness can also be associated with severe respiratory diseases and high mortality rates. Well-characterized multiplexed serologic assays are needed to aid in rapid detection and surveillance of hCoVs. The present study describes development and evaluation of a multiplexed magnetic microsphere immunoassay (MMIA) to simultaneously detect immunoglobulin G (IgG) antibodies specific for recombinant nucleocapsid proteins (recN) from hCoVs 229E, NL63, OC43, HKU1, SARS-CoV, and MERS-CoV. Read More

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http://www.nature.com/articles/s41598-018-37747-5
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http://dx.doi.org/10.1038/s41598-018-37747-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362100PMC
February 2019
4 Reads

Nearly Complete Genome Sequence of a Human Norovirus GII.P17-GII.17 Strain Isolated from Brazil in 2015.

Microbiol Resour Announc 2019 Jan 31;8(5). Epub 2019 Jan 31.

Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.

Human noroviruses are the most common cause of nonbacterial acute gastroenteritis worldwide. We report here the nearly complete genome sequence (7,551 nucleotides) of a human norovirus GII.P17-GII. Read More

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http://dx.doi.org/10.1128/MRA.01376-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357637PMC
January 2019
1 Read

Evaluation of different genomic regions of Rotavirus A for development of real time PCR.

J Virol Methods 2019 Apr 30;266:65-71. Epub 2019 Jan 30.

Enteric Viruses Group, ICMR-National Institute of Virology, Pune, India. Electronic address:

The nucleotide alignment of all 11 genes of human Rotavirus A (RVA) strains revealed suitability of NSP2, NSP3 and VP6 genes for the development of real time PCR (qRT-PCR). Evaluation of qRT-PCR assays using known rotavirus ELISA positive and negative fecal specimens showed non-overlapping ranges of Mean ±3SD cycle threshold (Ct) values for NSP3 and VP6 based assays. Using serial dilutions of purified RVA, high sensitivity of VP6 qRT-PCR assay (1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183058
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http://dx.doi.org/10.1016/j.jviromet.2019.01.017DOI Listing
April 2019
2 Reads

Quantitative risk assessment of norovirus and adenovirus for the use of reclaimed water to irrigate lettuce in Catalonia.

Water Res 2019 Apr 11;153:91-99. Epub 2019 Jan 11.

Laboratory of Virus Contaminants of Water and Food, Section of Microbiology, Virology and Biotechnology, Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Avinguda Diagonal 643, 08028, Barcelona, Catalonia, Spain. Electronic address:

Wastewater is an important resource in water-scarce regions of the world, and its use in agriculture requires the guarantee of acceptable public health risks. The use of fecal indicator bacteria to evaluate safety does not represent viruses, the main potential health hazards. Viral pathogens could complement the use of fecal indicator bacteria in the evaluation of water quality. Read More

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http://dx.doi.org/10.1016/j.watres.2018.12.070DOI Listing
April 2019
1 Read

Gastroenteritis in Children.

Am Fam Physician 2019 Feb;99(3):159-165

University of Rochester Medical Center, Rochester, NY, USA.

Acute gastroenteritis is defined as a diarrheal disease of rapid onset, with or without nausea, vomiting, fever, or abdominal pain. In the United States, acute gastroenteritis accounts for 1.5 million office visits, 200,000 hospitalizations, and 300 deaths in children each year. Read More

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February 2019
2 Reads

The association between consuming bivalves, and acute gastroenteritis and norovirus in Tokyo, Japan.

J Med Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.

A prospective matched case-control study was conducted to evaluate associations between dietary histories, including consumption of bivalves, diarrhea, and norovirus positive diarrhea in adult ambulatory patients at an outpatient clinic of a hospital in Tokyo, Japan. Ambulatory cases with diarrhea were matched with nondiarrheal control patients, who visited the same clinic. A standardized questionnaire was used to obtain patients' information, including histories of food consumption and clinical information. Read More

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http://dx.doi.org/10.1002/jmv.25416DOI Listing
January 2019
1 Read

Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children.

Sci Rep 2019 Jan 29;9(1):865. Epub 2019 Jan 29.

Biomedical Research Center, Qatar University, Doha, 2713, Qatar.

Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Read More

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http://dx.doi.org/10.1038/s41598-018-37162-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351549PMC
January 2019
2 Reads
5.078 Impact Factor

Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study.

Lancet Respir Med 2019 Jan 24. Epub 2019 Jan 24.

Division of Respiratory Diseases, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Background: The efficacy, safety, and tolerability of lumacaftor and ivacaftor are established in patients aged 6 years and older with cystic fibrosis, homozygous for the F508del-CFTR mutation. We assessed the safety, pharmacokinetics, pharmacodynamics, and efficacy of lumacaftor and ivacaftor in children aged 2-5 years.

Methods: In this multicentre, phase 3, open-label, two-part study, we enrolled children aged 2-5 years, weighing at least 8 kg at enrolment, with a confirmed diagnosis of cystic fibrosis who were homozygous for the F508del-CFTR mutation. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30460-0DOI Listing
January 2019
1 Read

Bovine-like coronaviruses in domestic and wild ruminants.

Anim Health Res Rev 2018 Dec;19(2):113-124

Department of Virology, Faculty of Veterinary Medicine,Cairo University,11221 Giza,Egypt.

Coronaviruses (CoVs) produce a wide spectrum of disease syndromes in different mammalian and avian host species. These viruses are well-recognized for their ability to change tissue tropism, to hurdle the interspecies barriers and to adapt ecological variations. It is predicted that the inherent genetic diversity of CoVs caused by accumulation of point mutations and high frequency of homologous recombination is the principal determinant of these competences. Read More

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http://dx.doi.org/10.1017/S1466252318000117DOI Listing
December 2018
11 Reads

Cytomegalovirus pneumonia in a patient with T-lymphoblastic leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14221

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital.

Rationale: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for hematological malignancies. Common complications are opportunistic infections and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) is one of the most common causes of opportunistic infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358403PMC
January 2019
1 Read

[Noroviruses, these unknown worldwide epidemic enteropathogens].

Rev Med Liege 2019 Jan;74(1):41

Service de Virologie Vétérinaire et Maladies Virales Animales, Faculté de Médecine Vétérinaire, Centre FARAH, Liège Université, Liège, Belgique.

Discovered in the 1970s, human noroviruses (NoV) are the leading cause of foodborne disease and gastroenteritis outbreaks worldwide. NoV affect people of all ages. In children less than 5 years old, despite rotavirus remains the main enteropathogen responsible for viral gastroenteritis, NoV become the first etiological virus in countries where the rotavirus vaccine was introduced. Read More

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January 2019
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Missed Diagnosis of New-Onset Systolic Heart Failure at First Presentation in Children with No Known Heart Disease.

J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Houston, TX.

Objective: To determine frequency of missed heart failure diagnosis at first presentation among children with no known heart disease admitted with new-onset heart failure.

Study Design: Using a retrospective design, we reviewed electronic medical records of all patients aged <21 years with no known heart disease, hospitalized with new-onset heart failure during 2003-2015 at a tertiary-quaternary care institution. We assessed records for missed diagnosis of heart failure (primary outcome), associated process breakdowns, and clinical outcomes using a structured data collection instrument. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.029DOI Listing
January 2019
2 Reads
3.790 Impact Factor

Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses.

mSphere 2019 01 23;4(1). Epub 2019 Jan 23.

Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Viral Metagenomics, KU Leuven-University of Leuven, Leuven, Belgium

Diarrhea remains one of the most common causes of deaths in children. A limited number of studies have investigated the prevalence of enteric pathogens in Cameroon, and as in many other African countries, the cause of many diarrheal episodes remains unexplained. A proportion of these unknown cases of diarrhea are likely caused by yet-unidentified viral agents, some of which could be the result of (recent) interspecies transmission from animal reservoirs, like bats. Read More

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http://dx.doi.org/10.1128/mSphere.00585-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344602PMC
January 2019
1 Read

Pathogenesis of Human Norovirus Genogroup II Genotype 4 in Post-Weaning Gnotobiotic Pigs.

J Microbiol Biotechnol 2018 Dec;28(12):2133-2140

Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.

Norovirus is the most common cause of acute gastroenteritis. Its pathogenesis is poorly understood owing to the difficulty of establishing viral infection in animal models. Here, post-weaning gnotobiotic pigs were infected with human norovirus genogroup II genotype 4 (HuNoV GII. Read More

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http://dx.doi.org/10.4014/jmb.1809.09061DOI Listing
December 2018
15 Reads

Critical issues in application of molecular methods to environmental virology.

J Virol Methods 2019 Apr 16;266:11-24. Epub 2019 Jan 16.

Department of Civil & Environmental Engineering & Earth Sciences, University of Notre Dame, USA.

Waterborne diseases have significant public health and socioeconomic implications worldwide. Many viral pathogens are commonly associated with water-related diseases, namely enteric viruses. Also, novel recently discovered human-associated viruses have been shown to be a causative agent of gastroenteritis or other clinical symptoms. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.01.008DOI Listing
April 2019
3 Reads

Should we pay attention to recombinant norovirus strain GII.P7/GII.6?

J Infect Public Health 2019 Jan 15. Epub 2019 Jan 15.

Fengtai District Center for Disease Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071, China. Electronic address:

Background: Recombinant norovirus strain GII.P7/GII.6 has been circulating in Asia and around the world for at least 20 years, but has been responsible for relatively few outbreaks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341183033
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http://dx.doi.org/10.1016/j.jiph.2018.12.007DOI Listing
January 2019
5 Reads

History of detention and the risk of hepatitis C among people who inject drugs in Germany.

Int J Infect Dis 2019 Jan 15. Epub 2019 Jan 15.

Department for Infectious Disease Epidemiology, Division for HIV/AIDS, STI and Blood-borne Infections, Robert Koch Institute, Berlin, Germany. Electronic address:

Objectives: To investigate the association between detention experience and HCV status, the role of detention duration and frequency and whether risk behaviours practiced in detention could explain an observed increase in risk.

Methods: Current drug injectors (injecting in the last 12 months) were recruited to participate in a sero-behavioural, cross-sectional survey using respondent-driven sampling in eight German cities, 2011-2014. Using multivariable logistic regression the association between HCV status and reported detention experience was investigated. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.015DOI Listing
January 2019
3 Reads

Acute Dystonia Secondary to Domperidone in a Pediatric Patient.

Cureus 2018 Nov 13;10(11):e3587. Epub 2018 Nov 13.

Internal Medicine, Ayub Medical College, Abbottabad, PAK.

Domperidone is a dopamine-2 receptor (D2) antagonist. It is used as an antiemetic and has an excellent safety profile. We present a case of acute dystonia secondary to domperidone use in an 11-year-old girl. Read More

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http://dx.doi.org/10.7759/cureus.3587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333251PMC
November 2018
2 Reads

Factors Associated With Rotavirus Vaccine Coverage.

Pediatrics 2019 Jan 17. Epub 2019 Jan 17.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus vaccines (RVVs) were included in the US immunization program in 2006 and are coadministered with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine, yet their coverage lags behind DTaP. We assessed timing, initiation, and completion of the RVV series among children enrolled in active gastroenteritis surveillance at 7 US medical institutions during 2014-2016.

Methods: We compared coverage and timing of each vaccine series and analyzed characteristics associated with RVV initiation and completion. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1824DOI Listing
January 2019
8 Reads

Polymerase chain reaction combined with fluorescent lateral flow immunoassay based on magnetic purification for rapid detection of canine parvovirus 2.

BMC Vet Res 2019 Jan 17;15(1):30. Epub 2019 Jan 17.

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering and Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, No. 2, Sipailou, Xuanwu District, Nanjing, Jiangsu Province, 210096, People's Republic of China.

Background: Canine parvovirus 2 (CPV-2) is one of the most common etiological agents that cause severe gastroenteritis in puppies. Early accurate diagnosis is important for infected dogs. In recent years, magnetic separation has become an efficient and useful tool for bioassays. Read More

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http://dx.doi.org/10.1186/s12917-019-1774-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337814PMC
January 2019
3 Reads

Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico: An observational study.

Medicine (Baltimore) 2019 Jan;98(3):e14124

Laboratory of Clinical Research, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero.

The chronic inflammation and damage to the gastric epithelium induced by Helicobacter pylori (H. pylori) are the main risk factors for gastric cancer development. Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) induce chronic inflammation and have been found in gastric tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000014124DOI Listing
January 2019
5 Reads

Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity.

J Biol Chem 2019 Jan 15. Epub 2019 Jan 15.

University of Cambridge, United Kingdom.

Norovirus infections are a major cause of acute viral gastroenteritis and a significant burden on global human health. A vital process for norovirus replication is the processing of the nonstructural polyprotein by a viral protease into the viral components required to form the viral replication complex. This cleavage occurs at different rates, resulting in the accumulation of stable precursor forms. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006780DOI Listing
January 2019

Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016.

BMC Public Health 2019 Jan 15;19(1):69. Epub 2019 Jan 15.

Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: In 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 2017. We report four years of data on rotavirus gastroenteritis in hospitalized children < 5 years of age prior to vaccine introduction.

Methods: Children from 7 sites in southern and northern India hospitalized for diarrhoea were recruited between July 2012 and June 2016. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6406-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334384PMC
January 2019
5 Reads

Ultrasensitive Colorimetric Detection of Murine Norovirus Using NanoZyme Aptasensor.

Anal Chem 2019 Feb 20. Epub 2019 Feb 20.

Ian Potter NanoBioSensing Facility, NanoBiotechnology Research Laboratory (NBRL), School of Science , RMIT University , GPO Box 2476, Melbourne , VIC 3000 , Australia.

Human norovirus (NoV) remains the most common cause of viral gastroenteritis and the leading cause of viral foodborne outbreaks globally. NoV is highly pathogenic with an estimated median viral infective dose (ID) ranging from 18 to 1015 genome copies. For NoV detection, the only reliable and sensitive method available for detection and quantification is reverse transcription quantitative polymerase chain reaction (RTqPCR). Read More

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b03300
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http://dx.doi.org/10.1021/acs.analchem.8b03300DOI Listing
February 2019
16 Reads

Co-Infection by Waterborne Enteric Viruses in Children with Gastroenteritis in Nepal.

Healthcare (Basel) 2019 Jan 13;7(1). Epub 2019 Jan 13.

Interdisciplinary Center for River Basin Environment, University of Yamanashi, Yamanashi 400-8511, Japan.

Enteric viruses are highly contagious and a major cause of waterborne gastroenteritis in children younger than five years of age in developing world. This study examined the prevalence of enteric virus infection in children with gastroenteritis to identify risk factors for co-infections. In total, 107 stool samples were collected from patients with acute gastroenteritis along with samples of their household drinking water and other possible contamination sources, such as food and hand. Read More

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http://dx.doi.org/10.3390/healthcare7010009DOI Listing
January 2019
2 Reads

Genetic diversity of human parechoviruses in stool samples, Germany.

Infect Genet Evol 2019 Mar 9;68:280-285. Epub 2019 Jan 9.

Institute of Virology, Leipzig University, Leipzig, Germany.

Human parechoviruses (HPeV) are ubiquitous and mainly occur in early infancy. They are known to cause various clinical manifestations including acute gastroenteritis. To gain insight into the diversity of circulating HPeV genotypes, stool samples from patients (n = 539) with clinical signs of infectious gastroenteritis which showed negative results for other common viral and bacterial enteric pathogens were obtained during three years, 2008 to 2010. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.01.007DOI Listing
March 2019
4 Reads

Complete Genome Sequence of a Hepatitis E Virus Genotype 1e Strain from an Outbreak in Nigeria, 2017.

Microbiol Resour Announc 2019 Jan 3;8(1). Epub 2019 Jan 3.

Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany.

Hepatitis E virus genotype 1 (HEV-1) is associated with large epidemics. Notably, HEV subtype 1e (HEV-1e) has caused HEV outbreaks in sub-Saharan Africa. We report here the second full-length genome sequence of an HEV-1e strain (NG/17-0503) from a recent outbreak in Nigeria in 2017. Read More

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http://dx.doi.org/10.1128/MRA.01378-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318360PMC
January 2019
4 Reads

Epidemiology of enteric viruses in children with gastroenteritis in Ogun State, Nigeria.

J Med Virol 2019 Jan 13. Epub 2019 Jan 13.

Virology Laboratory, Infectious Diseases Division, Hospital de Clinicas, Universidade Federal do Parana, Curitiba, Brazil.

Acute gastroenteritis (AGE) remains a global public health concern and Nigeria is one of the two countries accounting for 42% of global under-5 deaths attributable to gastroenteritis. This study aimed to determine the prevalence, seasonality, and risk factors of enteric viruses (EVs) in children with AGE in Ogun State, Nigeria. Stool samples collected from children under-5 from three different hospitals between February 2015 and April 2017 were analyzed using molecular methods for the presence of four EVs (group A rotavirus [RVA], norovirus [NoV], human astrovirus [HAstV], and human adenovirus [HAdV]). Read More

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http://doi.wiley.com/10.1002/jmv.25399
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http://dx.doi.org/10.1002/jmv.25399DOI Listing
January 2019
8 Reads

Rates of hospitalization and death for all-cause and rotavirus acute gastroenteritis before rotavirus vaccine introduction in Kenya, 2010-2013.

BMC Infect Dis 2019 Jan 11;19(1):47. Epub 2019 Jan 11.

Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Rotavirus vaccine was introduced in Kenya immunization program in July 2014. Pre-vaccine disease burden estimates are important for assessing vaccine impact.

Methods: Children with acute gastroenteritis (AGE) (≥3 loose stools and/or ≥ 1 episode of unexplained vomiting followed by loose stool within a 24-h period), hospitalized in Siaya County Referral Hospital (SCRH) from January 2010 through December 2013 were enrolled. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3615-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330491PMC
January 2019
7 Reads
2.613 Impact Factor

Clinical characteristics and follow-up of benign convulsions with mild gastroenteritis among children.

Medicine (Baltimore) 2019 Jan;98(2):e14082

Benign convulsions with mild gastroenteritis have a high incidence in the North China, previous reports it has been caused by rotavirus infection, which is a non-febrile convulsion. In recent years, we observed that norovirus infection gradually increased all the years round and most of them are febrile convulsion.Retrospective analysis was performed on 55 pediatric patients with benign convulsions with mild gastroenteritis (CWG) who were admitted between January 2010 and January 2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000014082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336632PMC
January 2019

GII.4 NOROVIRUS PROTEASE SHOWS pH-SENSITIVE PROTEOLYSIS WITH A UNIQUE ARG-HIS PAIRING IN THE CATALYTIC SITE.

J Virol 2019 Jan 9. Epub 2019 Jan 9.

The Verna and Marrs McLean Department of Biochemistry and Molecular Biology; Department of Molecular Virology and Microbiology, Department of Pharmacology and Chemical Biology; Baylor College of Medicine, Houston, TX 77030

Human noroviruses (NoV) are the main cause of epidemic and sporadic gastroenteritis. Phylogenetically noroviruses are divided into seven genogroups with each divided into multiple genotypes. NoVs belonging to genogroup II and genotype 4 (GII. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01479-18
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http://dx.doi.org/10.1128/JVI.01479-18DOI Listing
January 2019
3 Reads