12,451 results match your criteria Gastroenteritis Viral


Human norovirus targets enteroendocrine epithelial cells in the small intestine.

Nat Commun 2020 Jun 2;11(1):2759. Epub 2020 Jun 2.

Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from one pediatric intestinal transplant recipient with severe gastroenteritis. Read More

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http://dx.doi.org/10.1038/s41467-020-16491-3DOI Listing

Prevalence of Eleven Infectious Viruses Causing Diarrhea in Korea.

Jpn J Infect Dis 2020 May 29. Epub 2020 May 29.

Department of Laboratory Medicine, Inje University College of Medicine.

Rotavirus and norovirus are well-known causes of viral infectious diarrhea. There are few reports about diarrhea caused by other viruses in Korea, although gastroenteritis attributable to other viruses is increasing worldwide. The aims of this study were to detect various causes of viral diarrhea and to investigate their prevalence. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.069DOI Listing

Phylodynamics of G4P[8] and G2P[4] strains of rotavirus A isolated in Russia in 2017 based on full-genome analyses.

Virus Genes 2020 May 29. Epub 2020 May 29.

Laboratory of Molecular Epidemiology of Viral Infections, I.N. Blokhina Nizhny Novgorod Research Institute of Epidemiology and Microbiology, 71 Malaya Yamskaya Str., Nizhny Novgorod, Russia, 603950.

Rotavirus A is a dynamically evolving pathogen causing acute gastroenteritis in children during the first years of life. In the present study, we conducted a phylodynamic analysis based on the complete sequences of 11 segments of rotaviruses with the G4P[8] and G2P[4] genotypes isolated in Russia in 2017. Since rotavirus has a segmented genome, our analysis was performed using the Bayesian approach based on separate samples of nucleotide sequences for each gene of the strains studied. Read More

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http://dx.doi.org/10.1007/s11262-020-01771-3DOI Listing

Features of Enteric Disease from Human Coronaviruses: Implications for COVID-19.

Authors:
Nevio Cimolai

J Med Virol 2020 May 28. Epub 2020 May 28.

Faculty of Medicine, The University of British Columbia and Children's and Women's Health Centre of British Columbia, 4480 Oak Street, Vancouver, B.C., V6H3V4.

Coronaviruses have long been studied in both human and veterinary fields. Whereas the initial detection of endemic human respiratory coronaviruses was problematic, detection of these and newly discovered human coronaviruses has been greatly facilitated with major advances in the laboratory. Nevertheless, technological factors can affect the accuracy and timeliness of virus detection. Read More

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http://dx.doi.org/10.1002/jmv.26066DOI Listing

Viral gastroenteritis in hospitalized patients: Evaluation of immunochromatographic methods for rapid detection in stool samples.

J Clin Virol 2020 May 15;128:104420. Epub 2020 May 15.

Enterovirus and Viral Gastroenteritis Unit, National Centre for Microbiology (CNM), Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain. Electronic address:

Background: . Viral infections are recognized as the most common cause of acute gastroenteritis (AGE). Virus detection by immune analytical methods is recommended for diagnosis because of its simplicity and low cost. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104420DOI Listing

Clinical significance of the fucosyltransferase 2 (FUT2) secretor status in children hospitalized with acute gastroenteritis in Taiwan.

J Formos Med Assoc 2020 May 21. Epub 2020 May 21.

Division of Pediatric Gastroenterology, Department of Pediatrics, Taipei Medical University Shuang Ho Hospital, No.291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan. Electronic address:

Background/purpose: The FUT2 gene is a histo-blood group antigen (HBGA) that determines the susceptibility to Norovirus (NoV) infection. This study investigated the clinical significance of the FUT2 gene profile and HBGA expression in NoV infection.

Methods: Fecal specimens were collected from children in Chang-Gung Children's Hospital with acute gastroenteritis (AGE). Read More

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http://dx.doi.org/10.1016/j.jfma.2020.04.017DOI Listing

Predominance of Norovirus GI.4 From Children With Acute Gastroenteritis In Jambi, Indonesia, 2019.

J Med Virol 2020 May 23. Epub 2020 May 23.

Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Norovirus (NoV) is one of the most important viral causes of acute gastroenteritis (AGE) in children worldwide. Only a few studies have reported AGE with NoV-positive in some cities in Indonesia. This study aimed to investigate the incidence and clinical characteristic of NoV infection, and also genotype distribution of NoV in children with AGE in Jambi, as the capital and the largest city of Jambi province, Indonesia. Read More

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http://dx.doi.org/10.1002/jmv.26057DOI Listing

Hepatitis E Virus Seroprevalence and Associated Risk Factors in Apparently Healthy Individuals from Osun State, Nigeria.

Pathogens 2020 May 20;9(5). Epub 2020 May 20.

Department of Medical Microbiology and Parasitology, Ladoke Akintola University of Technology, Osogbo PMB 4400, Nigeria.

Hepatitis E virus (HEV) infection is a major public health concern in low-income countries, yet incidence and prevalence estimates are often lacking. Serum ( = 653) and faecal ( = 150) samples were collected from apparently healthy individuals using convenience sampling technique in six communities (Ore, Oke-Osun, Osogbo, Ede, Esa-Odo, and Iperindo) from Osun State, Nigeria. Serum samples were analysed for total anti-HEV IgG/IgM and anti-HEV IgM using commercially available HEV ELISA kits. Read More

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http://dx.doi.org/10.3390/pathogens9050392DOI Listing

A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis.

Nat Commun 2020 May 21;11(1):2533. Epub 2020 May 21.

University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

Gastroenteritis accounts for nearly 500,000 deaths in children younger than 5 years annually. Although probiotics have been touted as having the potential to expedite diarrhea resolution, recent clinical trials question their effectiveness. A potential explanation is a shift in pathogens following the introduction of a rotavirus vaccine. Read More

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http://dx.doi.org/10.1038/s41467-020-16308-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242434PMC

Rotavirus infection in children in Southeast Asia 2008-2018: disease burden, genotype distribution, seasonality, and vaccination.

J Biomed Sci 2020 May 21;27(1):66. Epub 2020 May 21.

Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Rotaviruses (RVs) are recognized as a major cause of acute gastroenteritis (AGE) in infants and young children worldwide. Here we summarize the virology, disease burden, prevalence, distribution of genotypes and seasonality of RVs, and the current status of RV vaccination in Southeast Asia (Cambodia, Indonesia, Lao People's Democratic Republic, Malaysia, Myanmar, Philippines, Singapore, Thailand, and Vietnam) from 2008 to 2018.

Methods: Rotavirus infection in Children in Southeast Asia countries was assessed using data from Pubmed and Google Scholars. Read More

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http://dx.doi.org/10.1186/s12929-020-00649-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239768PMC

First Molecular Identification of Canine Parvovirus Type 2 (CPV2) in Chile Reveals High Occurrence of CPV2c Antigenic Variant.

Front Vet Sci 2020 5;7:194. Epub 2020 May 5.

Departamento de Patología y Medicina Preventiva, Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, Chile.

Canine parvovirus type 2 (CPV2) is one of the most important intestinal pathogens in dogs and puppies. CPV2 has been evolved into three genetic and antigenic variants (2a, 2b, and 2c), which are distributed worldwide. We reported the first study of genetic diversity of CPV2 in Chile. Read More

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http://dx.doi.org/10.3389/fvets.2020.00194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216333PMC

Effect of rotavirus vaccine implementation on the prevalence of co-infections with enteric viruses in Norway.

J Med Virol 2020 May 15. Epub 2020 May 15.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.

Background: Acute gastroenteritis (AGE) is a common illness in both adults and children worldwide and is caused by several microorganisms including viruses, bacteria and parasites. Rotavirus (RV), which is the main cause of AGE, can occur as a mixed infection with other viruses. The aim of this study is to assess the molecular epidemiology of viral enteric viruses and assess RV co-infections with other enteric viruses and their influence on disease severity before and after RV vaccine introduction in children under 5 years of age. Read More

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http://dx.doi.org/10.1002/jmv.26013DOI Listing

Norovirus gastroenteritis outbreaks in military units: a systematic review.

BMJ Mil Health 2020 May 13. Epub 2020 May 13.

Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto (FFUP), Porto, Portugal.

Introduction: Norovirus gastroenteritis is one of the most frequent causes of personnel unavailability in military units, being associated with significant morbidity and degradation of their operational effectiveness. The disease is usually mild but can be severe and life-threatening in young and healthy soldiers, who are prone to dehydration due to intensive daily activity. Despite its impact, the full extent of the norovirus gastroenteritis burden in military forces remains unclear. Read More

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http://dx.doi.org/10.1136/bmjmilitary-2019-001341DOI Listing

Editorial: increasing IBD prevalence and its complications in the context of the COVID-19 pandemic.

Aliment Pharmacol Ther 2020 06 14;51(12):1441-1442. Epub 2020 May 14.

Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand.

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http://dx.doi.org/10.1111/apt.15759DOI Listing

Editorial: increasing IBD prevalence and its complications in the context of the COVID-19 pandemic. Authors' reply.

Aliment Pharmacol Ther 2020 06 14;51(12):1442-1443. Epub 2020 May 14.

IAHR, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/apt.15769DOI Listing

Describing the Epidemiology of Foodborne Outbreaks in New South Wales from 2000 to 2017.

Foodborne Pathog Dis 2020 May 12. Epub 2020 May 12.

National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, Canberra, Australia.

Foodborne disease causes an estimated 4.1 million cases of illness in Australia each year and is responsible for causing many significant common source outbreaks. We analyzed 18 years of foodborne outbreak data collected in New South Wales (NSW), and classified the likely pathogen type responsible for outbreaks of unknown etiology, to track broad trends over time. Read More

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http://dx.doi.org/10.1089/fpd.2020.2806DOI Listing

Molecular evolution of the capsid () region in human norovirus genogroup II genotype 3.

Heliyon 2020 May 3;6(5):e03835. Epub 2020 May 3.

Department of Health Science, Gunma Paz University Graduate School of Health Sciences, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.

Norovirus GII.3 has been suggested to be a prevalent genotype in patients with acute gastroenteritis. However, the genetic properties of the region encoding the major GII. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205756PMC

Genomic Analyses of Human Sapoviruses Detected over a 40-Year Period Reveal Disparate Patterns of Evolution among Genotypes and Genome Regions.

Viruses 2020 May 7;12(5). Epub 2020 May 7.

Division of Viral Products, CBER, FDA, Silver Spring, MD 20993, USA.

Human sapovirus is a causative agent of acute gastroenteritis in all age groups. The use of full-length viral genomes has proven beneficial to investigate evolutionary dynamics and transmission chains. In this study, we developed a full-length genome sequencing platform for human sapovirus and sequenced the oldest available strains (collected in the 1970s) to analyse diversification of sapoviruses. Read More

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http://dx.doi.org/10.3390/v12050516DOI Listing

[Disease spectrum among guests and staff of an international luxury beach resort in the tropics].

Authors:
Andreas Fichtner

Med Klin Intensivmed Notfmed 2020 May 7. Epub 2020 May 7.

Notfall- und OP-Management, Kreiskrankenhaus Freiberg gGmbH, Donatsring 20, 09599, Freiberg, Deutschland.

Background: Diseases of travelers upon returning home are described in numerous publications. However, we have limited data on the disease spectrum and the reasons for medical consultations during a trip.

Methods: Over the period of one year, we analyzed all patient visits to the inhouse medical center of a major 5‑star beach resort of an international chain in the Maldives. Read More

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http://dx.doi.org/10.1007/s00063-020-00691-2DOI Listing

Rapid and visual detection of porcine deltacoronavirus by recombinase polymerase amplification combined with a lateral flow dipstick.

BMC Vet Res 2020 May 7;16(1):130. Epub 2020 May 7.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of the Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.

Background: Porcine Deltacoronavirus (PDCoV) is a newly emerging Coronavirus that was first identified in 2012 in Hong Kong, China. Since then, PDCoV has subsequently been reported worldwide, causing a high number of neonatal piglet deaths and significant economic losses to the swine industry. Therefore, it is necessary to establish a highly sensitive and specific method for the rapid diagnosis of PDCoV. Read More

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http://dx.doi.org/10.1186/s12917-020-02341-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203717PMC

Genomic Analyses of Potential Novel Recombinant Human Adenovirus C in Brazil.

Viruses 2020 May 4;12(5). Epub 2020 May 4.

Polytechnic School of University of Sao Paulo, Sao Paulo 01246-903, Brazil.

Human Adenovirus species C (HAdV-C) is the most common etiologic agent of respiratory disease. In the present study, we characterized the nearly full-length genome of one potential new HAdV-C recombinant strain constituted by Penton and Fiber proteins belonging to type 89 and a chimeric Hexon protein of types 1 and 89. By using viral metagenomics techniques, we screened out, in the states of Tocantins and Pará, Northern and North regions of Brazil, from 2010 to 2016, 251 fecal samples of children between 0. Read More

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http://dx.doi.org/10.3390/v12050508DOI Listing
May 2020
3.279 Impact Factor

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins.

J Vis Exp 2020 Apr 17(158). Epub 2020 Apr 17.

Department of Biology, Indiana University;

Rotaviruses are a large and evolving population of segmented double-stranded RNA viruses that cause severe gastroenteritis in the young of many mammalian and avian host species, including humans. With the recent advent of rotavirus reverse genetics systems, it has become possible to use directed mutagenesis to explore rotavirus biology, modify and optimize existing rotavirus vaccines, and develop rotavirus multitarget vaccine vectors. In this report, we describe a simplified reverse genetics system that allows the efficient and reliable recovery of recombinant rotaviruses. Read More

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http://dx.doi.org/10.3791/61039DOI Listing

Going Viral: Management of IBD in the Era of the COVID-19 Pandemic.

Dig Dis Sci 2020 06;65(6):1571-1575

Department of Gastroenterology and Hepatology, Kaiser Permanente, 3600 Broadway, 2nd Floor, Oakland, CA, 94611, USA.

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http://dx.doi.org/10.1007/s10620-020-06299-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196441PMC

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

J Biol Chem 2020 Apr 30. Epub 2020 Apr 30.

Erasmus Medical Center Rotterdam, Netherlands.

Noroviruses are the main causative agents of acute viral gastroenteritis, but the host factors that restrict their replication remain poorly identified. Guanylate-binding proteins (GBPs) are IFN-inducible GTPases that exert broad antiviral activity and are important mediators of host defenses against viral infections. Here, we show that both IFN-γ stimulation and murine norovirus (MNV) infection induce GBP2 expression in murine macrophages. Read More

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http://dx.doi.org/10.1074/jbc.RA120.013544DOI Listing
April 2020
4.573 Impact Factor

Validation of a Laboratory-Developed Triplex Molecular Assay for Simultaneous Detection of Gastrointestinal Adenovirus and Rotavirus in Stool Specimens.

Pathogens 2020 Apr 27;9(5). Epub 2020 Apr 27.

Public Health Ontario Laboratory, 661 University Avenue, Toronto, ON M5G 1M1, Canada.

Enteric viral pathogens causing gastroenteritis include adenovirus and rotavirus, among others. Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide. Among the adenoviruses known to cause gastroenteritis are those of species F (serotypes 40, 41). Read More

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http://dx.doi.org/10.3390/pathogens9050326DOI Listing

A Comprehensive Review on Human Aichi Virus.

Virol Sin 2020 Apr 27. Epub 2020 Apr 27.

Departamento de Microbiología y Parasitología, CIBUS-Facultad de Biología, Universidade de Santiago de Compostela, 15782, Santiago, Spain.

Although norovirus, rotavirus, adenovirus and Astrovirus are considered the most important viral agents transmitted by food and water, in recent years other viruses, such as Aichi virus (AiV), have emerged as responsible for gastroenteritis outbreaks associated with different foods. AiV belongs to the genus Kobuvirus of the family Picornaviridae. It is a virus with icosahedral morphology that presents a single stranded RNA genome with positive sense (8280 nucleotides) and a poly (A) chain. Read More

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http://dx.doi.org/10.1007/s12250-020-00222-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223127PMC

Spatial and temporal profiles of enteric viruses in the coastal waters of Tokyo Bay during and after a series of rainfall events.

Sci Total Environ 2020 Jul 6;727:138502. Epub 2020 Apr 6.

Department of Urban Engineering, The University of Tokyo, Tokyo, Japan. Electronic address:

Recreational activities in coastal waters that are polluted by enteric viruses can result in gastroenteritis etc. In this study, the pollution profiles of enteric viruses were examined in the coastal area of Tokyo Bay, Japan, by collecting 57 water samples from three different depths (0.5 m, 3. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138502DOI Listing

Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.

Nat Commun 2020 Apr 24;11(1):2013. Epub 2020 Apr 24.

Junior Research Group Infection Biology of Salmonella, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.

The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and FljB, are methylated at surface-exposed lysine residues by FliB. Read More

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http://dx.doi.org/10.1038/s41467-020-15738-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181671PMC

ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity.

Adv Sci (Weinh) 2020 Apr 27;7(8):1902130. Epub 2020 Feb 27.

Institute of Virology School of Medicine Technical University of Munich 85764 Munich Germany.

Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis. In the absence of protective immunity, as in allogeneic bone marrow transplant patients, HAdV infections can become lethal. Alarmingly, various outbreaks of highly pathogenic, pneumotropic HAdV types have been recently reported, causing severe and lethal respiratory diseases. Read More

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http://dx.doi.org/10.1002/advs.201902130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175289PMC

Rotavirus Vaccine is Effective Against Rotavirus Gastroenteritis Resulting in Outpatient Care: Results from the MAAGE Study.

Clin Infect Dis 2020 Apr 23. Epub 2020 Apr 23.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Rotavirus is a common cause of severe pediatric acute gastroenteritis (AGE). Two vaccines are licensed in the United States and have demonstrated high effectiveness against moderate to severe disease. However, fewer data are available on rotavirus vaccine effectiveness (VE) against milder disease. Read More

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http://dx.doi.org/10.1093/cid/ciaa466DOI Listing

Identification of two divergent swine Noroviruses detected at the slaughterhouse in North East Italy.

Porcine Health Manag 2020 16;6. Epub 2020 Apr 16.

3Diagnostic Virology Laboratory, Department of Animal Health, Istituto Zooprofilattico Sperimentale Delle Venezie, Legnaro, Padua, Italy.

Norovirus (NoV) has emerged as one of the major causative agents of non-bacterial, food- and water-borne gastroenteritis in humans, with the main genogroup involved in human outbreaks (GII), which has been detected worldwide in different animal species including swine. A four-month investigation at the slaughterhouse aiming to examine the presence of NoV in the swine in North-Eastern Italy, enabled the detection of two divergent Noroviruses (NoVs) (GII.P11) in two swine farms. Read More

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http://dx.doi.org/10.1186/s40813-020-00147-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160966PMC

Nanobody mediated neutralization reveals an Achilles heel for norovirus.

J Virol 2020 Apr 22. Epub 2020 Apr 22.

Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg, Germany

Human norovirus frequently causes outbreaks of acute gastroenteritis. Although discovered more than five decades ago, antiviral development has, until recently, been hampered by the lack of a reliable human norovirus cell culture system. Nevertheless, a lot of pathogenesis studies were accomplished using murine norovirus (MNV), which can be grown routinely in cell culture. Read More

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http://dx.doi.org/10.1128/JVI.00660-20DOI Listing

Management of inflammatory bowel disease patients in the COVID-19 pandemic era: a Brazilian tertiary referral center guidance.

Clinics (Sao Paulo) 2020 17;75:e1909. Epub 2020 Apr 17.

Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153358PMC

Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity.

Aliment Pharmacol Ther 2020 06 28;51(12):1434-1437. Epub 2020 Apr 28.

Department of Medical Gerontology, Mercers Institute for Ageing, St James Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1111/apt.15777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264531PMC

Prevention of COVID-19 in patients with inflammatory bowel disease in Wuhan, China.

Lancet Gastroenterol Hepatol 2020 06 17;5(6):525-527. Epub 2020 Apr 17.

Department of Gastroenterology, Key Laboratory of Hubei Province for Digestive System Disease, and Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(20)30121-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164865PMC

[Our experience in laboratory diagnosis of rotaviruses].

Klin Mikrobiol Infekc Lek 2019 Dec;25(4):140-144

Institute of Microbiology, Faculty of Medicine, Masaryk University Anna in Brno, Czech Republic, e-mail:

Objective: Group A rotavirus (RVA) is one of leading causes of gastroenteritis in children under five years of age and is also an important nosocomial pathogen. In Europe, the most prevalent genotypes of RVA are G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]. Severe dehydration is the most important complication of RVA gastroenteritis. Read More

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December 2019

Pediatric Surgery in the Time of COVID-19.

Authors:
Mark L Wulkan

J Laparoendosc Adv Surg Tech A 2020 04;30(4):355

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http://dx.doi.org/10.1089/lap.2020.29031.mlwDOI Listing

Screening for Components/Compounds with Anti-Rotavirus Activity: Detection of Interaction Between Viral Spike Proteins and Glycans.

Methods Mol Biol 2020 ;2132:585-595

Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.

Rotaviruses are the major etiologic agents of acute gastroenteritis. Viral attachment to the cell surface is crucial to initiate infection. The VP8 domain, the trypsinized cleavage fragment of the outermost spike protein VP4 of rotavirus, has a galectin-like structure required for binding to the cell surface. Read More

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http://dx.doi.org/10.1007/978-1-0716-0430-4_50DOI Listing
January 2020

Endoscopy in inflammatory bowel diseases during the COVID-19 pandemic and post-pandemic period.

Lancet Gastroenterol Hepatol 2020 06 16;5(6):598-606. Epub 2020 Apr 16.

Center for Inflammatory Bowel Disease, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, NY, USA.

The coronavirus disease 2019 (COVID-19) pandemic is changing the management of many chronic diseases, including that of patients with inflammatory bowel diseases (IBD). In particular, the performance of routine endoscopy is temporarily suspended, and only emergency endoscopy is allowed in many countries where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread. We highlight different scenarios in which endoscopy should still be performed urgently in patients with IBD, as well as recommendations regarding the use of personal protective equipment. Read More

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http://dx.doi.org/10.1016/S2468-1253(20)30119-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162648PMC

British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic.

Gut 2020 06 17;69(6):984-990. Epub 2020 Apr 17.

University of Edinburgh, Edinburgh, UK

The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be made to protect our patients and the clinical services they rely on. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-321244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211081PMC
June 2020
14.660 Impact Factor

Clinical features of covid-19.

BMJ 2020 Apr 17;369:m1470. Epub 2020 Apr 17.

Laboratory of Virology, Geneva University Hospitals, 1211 Geneva 14, Geneva, Switzerland.

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http://dx.doi.org/10.1136/bmj.m1470DOI Listing

Canine parvovirus and pseudorabies virus coinfection as a cause of death in a wolf (Canis lupus) from southern Italy.

Vet Med Sci 2020 Apr 16. Epub 2020 Apr 16.

Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Portici, Italy.

Pseudorabies virus (PRV) or suid herpesvirus 1 (SHV-1) is the causative agent of Aujeszky's disease, a highly contagious viral infection which causes neurological fatal illness in mammals other than suids. Here we report a case of a young wolf (Canis lupus) of around 2 years found dead by a hunter in the province of Avellino, Campania Region. Necropsy showed pathological findings consistent with encephalitis and gastroenteritis. Read More

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http://dx.doi.org/10.1002/vms3.270DOI Listing

A systematic review and meta-analysis: The Effectiveness of probiotics for viral gastroenteritis.

Curr Pharm Biotechnol 2020 Apr 16. Epub 2020 Apr 16.

Department of Food Sciences and Nutrition, Maragheh University of Medical Sciences, Maragheh. Iran.

Background: Probiotics can be used for the treatment of viral gastroenteritis.

Objective: This systematic review is to evaluate the evidence regarding the effect of probiotics on human cases of viral gastroenteritis.

Methods: The objective of this review is to evaluate the effectiveness of probiotics versus placebo or standard treatment for viral gastroenteritis. Read More

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http://dx.doi.org/10.2174/1389201021666200416123931DOI Listing

Prevalence and molecular characterization of parechovirus A in children with acute gastroenteritis in Shenzhen, 2016-2018.

Arch Virol 2020 Jun 15;165(6):1377-1384. Epub 2020 Apr 15.

Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, 510515, China.

Parechovirus A (PeV-A), which causes a wide variety of diseases, is prevalent among young children. However, little is currently known about PeV-A infections in children with acute gastroenteritis in mainland China. In this study, we investigated the molecular epidemiology of acute gastroenteritis in Shenzhen, southern China, with an emphasis on PeV-A infections. Read More

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http://dx.doi.org/10.1007/s00705-020-04587-6DOI Listing

Gut stem cell necroptosis by genome instability triggers bowel inflammation.

Nature 2020 04 25;580(7803):386-390. Epub 2020 Mar 25.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.

The aetiology of inflammatory bowel disease (IBD) is a multifactorial interplay between heredity and environment. Here we report that deficiency in SETDB1, a histone methyltransferase that mediates the trimethylation of histone H3 at lysine 9, participates in the pathogenesis of IBD. We found that levels of SETDB1 are decreased in patients with IBD, and that mice with reduced SETDB1 in intestinal stem cells developed spontaneous terminal ileitis and colitis. Read More

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http://dx.doi.org/10.1038/s41586-020-2127-xDOI Listing

[Epidemiological and etiological surveillance on infectious diarrhea in Pudong New Area, Shanghai, 2013-2017].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Mar;41(3):417-422

Department of Microbiology, Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China; Pudong Institute of Preventive Medicine, Fudan University, Shanghai 200136, China.

To understand the epidemiological characteristics of infectious diarrhea pathogens in Pudong New Areas of Shanghai from 2013 to 2017 to provide evidence for control and prevention of the disease. From Jan 2013 to Dec 2017, active surveillance program on diarrhea was conducted in 14 sentinel hospitals (three tertiary-level and nine secondary-level, and two primary-level hospitals) in Pudong New Areas of Shanghai, based on location, catchment areas and number of patients. All recruited outpatients were interviewed in hospitals, using a standard questionnaire. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2020.03.026DOI Listing

Concerns related to COVID-19 pandemic among patients with inflammatory bowel disease and its influence on patient management.

Eur J Clin Invest 2020 05 9;50(5):e13233. Epub 2020 May 9.

Gastroenterology Unit, Department of Internal Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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http://dx.doi.org/10.1111/eci.13233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235524PMC

The Burden of Norovirus in the United States, as Estimated Based on Administrative Data: Updates for Medically Attended Illness and Mortality, 2001 - 2015.

Clin Infect Dis 2020 Apr 14. Epub 2020 Apr 14.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Up-to-date estimates of the burden of norovirus, a leading cause of acute gastroenteritis (AGE) in the United States, are needed to assess the potential value of norovirus vaccines in development. We aimed to estimate the rates, annual counts, and healthcare charges of norovirus-associated ambulatory clinic encounters, Emergency Department (ED) visits, hospitalizations, and deaths in the United States.

Methods: We analyzed administrative data on AGE outcomes from July 1, 2001 through June 30, 2015. Read More

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http://dx.doi.org/10.1093/cid/ciaa438DOI Listing

Virus-Host Interactions Between Nonsecretors and Human Norovirus.

Cell Mol Gastroenterol Hepatol 2020 Apr 11. Epub 2020 Apr 11.

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

Background & Aims: Human norovirus infection is the leading cause of acute gastroenteritis. Genetic polymorphisms, mediated by the FUT2 gene (secretor enzyme), define strain susceptibility. Secretors express a diverse set of fucosylated histoblood group antigen carbohydrates (HBGA) on mucosal cells; nonsecretors (FUT2) express a limited array of HBGAs. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2020.03.006DOI Listing

The daily impact of COVID-19 in gastroenterology.

United European Gastroenterol J 2020 06 11;8(5):520-527. Epub 2020 Apr 11.

Department of Gastroenterology, Université Catholique de Louvain, Yvoir, Belgium *Fernando Magro and Candida Abreu contributed equally to this work.

A new strain of coronavirus, called SARS-CoV-2, emerged in Wuhan, China, in December 2019, probably originating from a wild-animal contamination. Since then, the situation rapidly evolved from a cluster of patients with pneumonia, to a regional epidemic and now to a pandemic called COrona VIrus Disease 2019 (COVID-19). This evolution is related to the peculiar modes of transmission of the disease and to the globalization and lifestyle of the 21st century that created the perfect scenario for virus spread. Read More

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http://dx.doi.org/10.1177/2050640620920157DOI Listing