25,569 results match your criteria Gastroenteritis Bacterial


Yersinia pseudotuberculosis Infection Accompanied by Intussusception and Incomplete Kawasaki Disease in a 7-year-old Girl.

Keio J Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Pediatrics, National Hospital Organization Saitama Hospital, Saitama, Japan.

Infection with Yersinia pseudotuberculosis, a known causal pathogen of human bacterial gastroenteritis, causes various symptoms and complications. A previously healthy 7-year-old girl was admitted because of fever and gastrointestinal symptoms. She was initially diagnosed with intussusception by abdominal ultrasonography. Read More

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Simultaneous Molecular Detection of Common Bacterial Enteropathogens in Children with Diarrhea by Multiplex-PCR Assay.

Clin Lab 2021 Jun;67(6)

Background: Diarrhea remains a major threat to children in low- and middle-income countries, which is the second cause of death among children in the world. The aim of the present study was to develop and evaluate a multiplex-PCR assay for direct detection of common bacterial enteropathogens in fecal specimens.

Methods: One hundred and three stool specimens were collected from children under 5 years of age with gastroenteritis during a six-month period in Ilam, Iran. Read More

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Pathological lesions of the digestive tract in free-ranging mountain gorillas (Gorilla beringei beringei).

Am J Primatol 2021 Jun 7:e23290. Epub 2021 Jun 7.

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

The finding of parasites and bacterial pathogens in mountain gorilla feces and oral lesions in gorilla skeletal remains has not been linked to pathological evidence of morbidity or mortality. In the current study, we conducted a retrospective study of digestive tracts including oral cavity, salivary glands, esophagus, stomach, intestines (gastrointestinal tract [GI]), liver, and pancreas of 60 free-ranging mountain gorillas from Uganda, Rwanda, and the Democratic Republic of Congo that died between 1985 and 2007. We reviewed clinical histories and gross pathology reports and examined histological sections. Read More

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Whole genome sequencing data used for surveillance of infections: detection of a large continuous outbreak, Denmark, 2019.

Euro Surveill 2021 Jun;26(22)

Statens Serum Institut, Department of Bacteria, Parasites and Fungi, Copenhagen, Denmark.

Background is one of the most frequent causes of bacterial gastroenteritis. outbreaks are rarely reported, which could be a reflection of a surveillance without routine molecular typing. We have previously shown that numerous small outbreak-like clusters can be detected when whole genome sequencing (WGS) data of clinical isolates was applied. Read More

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Transcriptomic analysis of caecal tissue in inbred chicken lines that exhibit heritable differences in resistance to Campylobacter jejuni.

BMC Genomics 2021 Jun 4;22(1):411. Epub 2021 Jun 4.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Background: Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans and the handling or consumption of contaminated poultry meat is a key source of infection. Selective breeding of poultry that exhibit elevated resistance to Campylobacter is an attractive control strategy. Here we studied the global transcriptional response of inbred chicken lines that differ in resistance to C. Read More

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An Investigation into the Critical Factors Influencing the Spread of during Chicken Handling in Commercial Kitchens in China.

Microorganisms 2021 May 28;9(6). Epub 2021 May 28.

Jiangsu Key Lab of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.

Campylobacteriosis is the most common cause of bacterial gastroenteritis worldwide. Consumption of chicken meat is considered the main route for human infection with . This study aimed to determine the critical factors for cross-contamination in Chinese commercial kitchens during chicken handling. Read More

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Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis.

Nat Commun 2021 05 28;12(1):3105. Epub 2021 May 28.

Departments of Medicine, Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented and treated chronic immune-mediated colitis. Read More

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Application value of tissue tuberculosis antigen combined with Xpert MTB/RIF detection in differential diagnoses of intestinal tuberculosis and Crohn's disease.

BMC Infect Dis 2021 May 28;21(1):498. Epub 2021 May 28.

Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang, China.

Background: The purpose of this study was to examine the value of Xpert MTB/RIF assay and detection of additional Mycobacterium tuberculosis complex (MTBC) species antigens from intestinal tissue samples in differentiating intestinal tuberculosis (ITB) from Crohn's disease (CD).

Methods: Several clinical specimens of intestinal tissue obtained by either endoscopic biopsy or surgical excision were used for mycobacteriologic solid cultures,Xpert MTB/RIF assays, immunohistochemistry, and histological examinations. Four antigens (38KDa, ESAT-6, MPT64, and Ag85 complex) of MTBC in the intestinal tissue were detected by immunohistochemical analysis. Read More

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Campylobacter jejuni ST50, a pathogen of global importance: A comparative genomic analysis of isolates from Australia, Europe and North America.

Zoonoses Public Health 2021 May 27. Epub 2021 May 27.

National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT, Australia.

Campylobacter jejuni is the leading cause of bacterial gastroenteritis globally, and infections are often transmitted through consumption of raw or undercooked poultry. Campylobacter jejuni ST50 is among the top ten sequence types (STs) reported in the collected isolates listed at PubMLST records from poultry, food and clinical sources for Asia, Europe, North America, Oceania and South America. This study was designed to determine the most commonly reported C. Read More

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A pilot study revealing host-associated genetic signatures for source attribution of sporadic Campylobacter jejuni infection in Egypt.

Transbound Emerg Dis 2021 May 25. Epub 2021 May 25.

Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt.

Campylobacter jejuni (C. jejuni), is considered among the most common bacterial causes of human bacterial gastroenteritis worldwide. The epidemiology and the transmission dynamics of campylobacteriosis in Egypt remain poorly defined due to the limited use of high-resolution typing methods. Read More

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The host cellular immune response to infection by spp. and its role in disease.

Infect Immun 2021 May 24. Epub 2021 May 24.

Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA

spp. are the leading cause of bacterial-derived gastroenteritis worldwide, impacting ninety-six million individuals annually. Unlike other bacterial pathogens of the gastrointestinal tract, spp. Read More

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Burden and etiology of moderate and severe diarrhea in children less than 5 years of age living in north and south of China: Prospective, population-based surveillance.

Gut Pathog 2021 May 24;13(1):33. Epub 2021 May 24.

Key Laboratory of Medical Molecular Virology of Ministry of Education & Ministry of Health, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, People's Republic of China.

Background: Diarrhea remains the leading cause of childhood illness in China. Better understanding of burden and etiology of diarrheal diseases is important for development of effective prevention measures.

Methods: Population-based diarrhea surveillance was conducted in Sanjiang (southern China) year-round and Zhengding (northern China) in autumn/winter. Read More

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Post-infection Irritable Bowel Syndrome.

Gastroenterol Clin North Am 2021 Jun 23;50(2):445-461. Epub 2021 Apr 23.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA; Department of Medicine and Physiology, Enteric NeuroScience Program, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:

Epidemiologic data support that acute gastrointestinal infection is one of the strongest risk factors for development of irritable bowel syndrome (IBS). Risk of post-infection IBS (PI-IBS) seems to be greater with bacterial and protozoal than viral enterocolitis. Younger individuals, women, and those with severe enterocolitis are more likely to develop PI-IBS. Read More

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Acute Bacterial Gastroenteritis.

Gastroenterol Clin North Am 2021 Jun 23;50(2):283-304. Epub 2021 Apr 23.

Department of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine, Campus Box 8051, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

Acute bacterial gastroenteritis is among the most common infections worldwide, with millions of infections annually in the United States. Much of the illness is foodborne, occurring as both sporadic cases and large multistate outbreaks. Pathogen evolution through genetic exchange of virulence traits and antibiotic resistance determinants poses challenges for empiric therapy. Read More

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Management of Acute Appendicitis during the COVID-19 Pandemic: A Single Tertiary Center Experience.

Isr Med Assoc J 2021 May;23(5):269-273

Department of Surgery and Transplantation B, Sheba Medical Center, Tel Hashomer, Israel.

Background: The coronavirus disease-2019 (COVID-19) outbreak had an effect on healthcare.

Objectives: To evaluate the presentation and management of patients with acute appendicitis.

Methods: A retrospective study was conducted of all patients presenting with acute appendicitis to the emergency department of a large tertiary center during March and April 2020. Read More

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Ovomucin Ameliorates Intestinal Barrier and Intestinal Bacteria to Attenuate DSS-Induced Colitis in Mice.

J Agric Food Chem 2021 Jun 20;69(21):5887-5896. Epub 2021 May 20.

College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China.

Egg white ovomucin (OVM) is homologically related to MUC2, the key component of colonic mucous layer. This study investigated the effects of orally administered OVM from egg white on the colonic mucosal barrier and the development of colitis using a colitis C57BL/6J mice model. The results showed that daily supplementation of 125 and 250 mg/kg BW of OVM partially relieved the villous destruction and loss of intestinal barrier integrity, and hence decreased the epithelial barrier permeability. Read More

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Cross-contamination of lettuce with Campylobacter spp. via cooking salt during handling raw poultry.

PLoS One 2021 19;16(5):e0250980. Epub 2021 May 19.

Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal.

Campylobacter spp. are the most common bacterial pathogens associated with human gastroenteritis in industrialized countries. Contaminated chicken is the food vehicle associated with the majority of reported cases of campylobacteriosis, either by the consumption of undercooked meat or via cross- contamination of ready-to-eat (RTE) foods during the handling of contaminated raw chicken parts and carcasses. Read More

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Transcription of Cystathionine β-lyase (MetC) is Repressed by HeuR in and Methionine Biosynthesis Facilitates Colonocyte Invasion.

J Bacteriol 2021 May 17. Epub 2021 May 17.

Department of Microbiology, University of Tennessee, Knoxville, Tennessee

A previously identified transcriptional regulator in , termed HeuR, was found to positively regulate heme utilization. Additionally, transcriptomic work demonstrated the putative operons, CJJ81176_1390-1394 and CJJ81176_1214-1217, were upregulated in a HeuR mutant, suggesting HeuR negatively regulates expression of these genes. Because genes within these clusters include a cystathionine β-lyase () and a methionine synthase (), it appeared HeuR negatively regulates methionine biosynthesis. Read More

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Aging-Induced Dysbiosis of Gut Microbiota as a Risk Factor for Increased Infection.

Front Immunol 2021 28;12:672353. Epub 2021 Apr 28.

Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, United States.

Invasive foodborne infection causes gastroenteritis, septicemia, meningitis, and chorioamnionitis, and is associated with high case-fatality rates in the elderly. It is unclear how aging alters gut microbiota, increases risk of listeriosis, and causes dysbiosis post-infection. We used a geriatric murine model of listeriosis as human surrogate of listeriosis for aging individuals to study the effect of aging and infection. Read More

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Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator.

J Med Invest 2021 ;68(1.2):59-70

Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University, Tokushima Japan.

Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Read More

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January 2021

Microbial Etiologies and Clinical Characteristics of Children Seeking Emergency Department Care due to Vomiting in the Absence of Diarrhea.

Clin Infect Dis 2021 May 16. Epub 2021 May 16.

Divisions of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Background: As children with isolated vomiting are rarely able to provide a specimen suitable for routine pathogen testing, we have limited knowledge about their infecting pathogens.

Methods: Between December 2014 and August 2018, children <18 years old with presumed acute gastroenteritis who presented to two emergency departments (ED) in Alberta, Canada were recruited. Eligible participants had ≥3 episodes of vomiting and/or diarrhoea in a 24-hour period, <7 days of symptoms, and provided a rectal swab or stool specimen. Read More

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Antimicrobial-resistance gene transfer of in mono- and dual-species biofilms.

Appl Environ Microbiol 2021 May 14. Epub 2021 May 14.

Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada

Horizontal gene transfer (HGT) is a driving force for the dissemination of antimicrobial resistance (AMR) genes among , a leading cause of foodborne gastroenteritis worldwide Although HGT is well documented for planktonic cells, the role of biofilms in AMR spread that likely to occur in the environment is poorly understood. Here, we developed a co-cultivation model to investigate the HGT of chromosomally-encoded AMR genes between two F38011 AMR mutants in biofilms. Compared to planktonic cells, biofilms significantly promoted HGT ( < 0. Read More

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Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei.

Nat Commun 2021 05 11;12(1):2684. Epub 2021 May 11.

Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Shigella sonnei is the most common agent of shigellosis in high-income countries, and causes a significant disease burden in low- and middle-income countries. Antimicrobial resistance is increasingly common in all settings. Whole genome sequencing (WGS) is increasingly utilised for S. Read More

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Recombinant Lactobacillus plantarum NC8 strain expressing porcine rotavirus VP7 induces specific antibodies in BALB/c mice.

Acta Biochim Biophys Sin (Shanghai) 2021 May;53(6):707-718

College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural University, Changchun 130118, China.

The major etiologic agent that causes acute gastroenteritis worldwide in young animals and children is Group A rotavirus. Currently, commercially available vaccines do not often prevent porcine rotavirus (PRV) infection. In this study, we evaluated the efficacy of oral recombinant Lactobacillus vaccine against PRV in a mouse model. Read More

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A rare case of emphysematous gastritis caused by Lactobacillus fermentum in a patient with diabetes.

Rev Esp Enferm Dig 2021 May 5. Epub 2021 May 5.

Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México.

A 42-year-old man with a history of type 2 diabetes mellitus (complicated by end stage renal disease on peritoneal dialysis) and chronic diarrhea was admitted to the emergency department for having an exacerbation in the number of evacuations. The patient was hypotensive and lethargic. Arterial blood gases were obtained and reported pH 7. Read More

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CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination.

Immun Inflamm Dis 2021 May 4. Epub 2021 May 4.

Immunology and Environment, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.

Introduction: Salmonella spp. are a recognized and global cause of serious health issues from gastroenteritis to invasive disease. The mouse model of human typhoid fever, which uses Salmonella enterica serovar Typhimurium (STM) in susceptible mouse strains, has revealed that the bacteria gain access to extraintestinal tissues from the gastrointestinal tract to cause severe systemic disease. Read More

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Neutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report.

BMC Womens Health 2021 05 3;21(1):187. Epub 2021 May 3.

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Enyacho 89-1, Izumo, Shimane, 6938501, Japan.

Background: Neutropenic enterocolitis (NE) is a potentially life-threatening disease that primarily occurs in cancer patients treated with chemotherapy. NE has substantial morbidity and mortality, and its incidence has increased with the widespread use of chemotherapeutic agents such as taxanes, gemcitabine, and leucovorin in patients with lung, breast, gastric, and ovarian cancers. Sometimes NE can be a possible cause of death. Read More

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Resveratrol Prevents -Induced Leaky gut by Restoring Occludin and Claudin-5 in the Paracellular Leak Pathway.

Front Pharmacol 2021 15;12:640572. Epub 2021 Apr 15.

Medical Department, Division of Gastroenterology, Infectious Diseases, Rheumatology, Nutritional Medicine/Clinical Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

is a bacterial human pathogen causing gastroenteritis and sequelae like irritable bowel syndrome. Epidemiologists count the human campylobacteriosis by as the most common foodborne zoonosis and bacterial diarrheal disease worldwide. Based on bioinformatics predictions for potential protective compounds in campylobacteriosis, the question was raised whether the plant-based polyphenol resveratrol is sufficient to attenuate intestinal epithelial damage induced by . Read More

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Evaluation of mobile real-time polymerase chain reaction tests for the detection of severe acute respiratory syndrome coronavirus 2.

Sci Rep 2021 04 30;11(1):9387. Epub 2021 Apr 30.

National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), calls for prompt and accurate diagnosis and rapid turnaround time for test results to limit transmission. Here, we evaluated two independent molecular assays, the Biomeme SARS-CoV-2 test, and the Precision Biomonitoring TripleLock SARS-CoV-2 test on a field-deployable point-of-care real-time PCR instrument, Franklin three9, in combination with Biomeme M1 Sample Prep Cartridge Kit for RNA 2.0 (M1) manual extraction system for rapid, specific, and sensitive detection of SARS-COV-2 in cell culture, human, and animal clinical samples. Read More

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Etiological, epidemiological, and clinical features of acute diarrhea in China.

Nat Commun 2021 04 29;12(1):2464. Epub 2021 Apr 29.

The Institute for Disease Prevention and Control of PLA, Beijing, China.

National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 eligible patients enrolled in this analysis. Rotavirus A and norovirus are the two leading viral pathogens detected in the patients, followed by adenovirus and astrovirus. Read More

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