24,669 results match your criteria Gastroenteritis Bacterial


Expression of the Campylobacter jejuni FliD protein and its reaction to chicken sera.

FEMS Microbiol Lett 2020 Jul 13. Epub 2020 Jul 13.

Jiangsu Institute of Poultry Sciences, Supervision, Inspection & Testing Centre for Poultry Quality (Yangzhou), Ministry of Agriculture, Yangzhou 225125, China.

Campylobacter is a leading causative pathogen of acute bacterial gastroenteritis among humans. Contaminated chicken products are regarded as major sources of human infection. The flagellar capping protein (FliD), which plays important roles in colonization and adhesion to the mucosal surface of chicken caeca, is conserved among Campylobacter jejuni strains. Read More

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http://dx.doi.org/10.1093/femsle/fnaa115DOI Listing

Protozoan infections are under-recognized in Swedish patients with gastrointestinal symptoms.

Eur J Clin Microbiol Infect Dis 2020 Jul 7. Epub 2020 Jul 7.

Clinical Microbiology, Region Jönköping County, Sweden and Department of Health, Medicine and Caring, Linköping University, Linköping, Sweden.

In acute gastroenteritis (GE), identification of the infectious agent is important for patient management and surveillance. The prevalence of GE caused by protozoa may be underestimated in Swedish patients. The purpose was to compare the prevalence of E. Read More

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http://dx.doi.org/10.1007/s10096-020-03974-wDOI Listing

Vaccine-mediated protection against -associated enteric disease.

Sci Adv 2020 Jun 24;6(26):eaba4511. Epub 2020 Jun 24.

Najít Technologies Inc., Beaverton, OR, USA.

and are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, vaccine development has been hampered by the lack of animal models that recapitulate human disease pathogenesis. Here, we describe a naturally occurring -associated diarrhea model in outdoor-housed rhesus macaques. Read More

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http://dx.doi.org/10.1126/sciadv.aba4511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314533PMC

Genome-Scale Metabolic Model Driven Design of a Defined Medium for M1cam.

Front Microbiol 2020 19;11:1072. Epub 2020 Jun 19.

Microbes in Food Chain, Quadram Institute Biosciences, Norwich Research Park, Norwich, United Kingdom.

, the most frequent cause of food-borne bacterial gastroenteritis, is a fastidious organism when grown in the laboratory. Oxygen is required for growth, despite the presence of the metabolic mechanism for anaerobic respiration. Amino acid auxotrophies are variably reported and energy metabolism can occur through several electron donor/acceptor combinations. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318876PMC

Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response.

Front Immunol 2020 16;11:961. Epub 2020 Jun 16.

Departamento de Biotecnología, Facultad de Ciencias del Mar y Recursos Biológicos, Universidad de Antofagasta, Antofagasta, Chile.

Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all ages. However, young children and older adults are the highest-risk groups, being affected with the greatest rate of hospitalizations and morbidity cases. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308418PMC

Incidence, etiology, and severity of acute gastroenteritis among prospectively enrolled patients in 4 Veterans Affairs hospitals and outpatient centers, 2016-18.

Clin Infect Dis 2020 Jun 25. Epub 2020 Jun 25.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Acute gastroenteritis (AGE) burden, etiology, and severity in adults is not well-characterized. We implemented a multisite AGE surveillance platform in 4 Veterans Affairs Medical Centers (Atlanta, Bronx, Houston and Los Angeles), collectively serving >320,000 patients annually.

Methods: From July 1, 2016-June 30, 2018, we actively identified AGE inpatient cases and non-AGE inpatient controls through prospective screening of admitted patients and passively identified outpatient cases through stool samples submitted for clinical diagnostics. Read More

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http://dx.doi.org/10.1093/cid/ciaa806DOI Listing

Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Infection.

Front Immunol 2020 9;11:1011. Epub 2020 Jun 9.

Humabs BioMed SA a Subsidiary of Vir Biotechnology Inc., Bellinzona, Switzerland.

infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory immunoglobulin A (SIgA) is the main antibody class found in mucous secretions, including human milk, and serves as the first line of defense for the gastrointestinal epithelium against enteric pathogens. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296071PMC

Genomic surveillance enables suitability assessment of gene targets used for culture-independent diagnostic testing.

J Clin Microbiol 2020 Jun 24. Epub 2020 Jun 24.

Sydney Medical School, The University of Sydney, NSW, AUSTRALIA.

is a highly diverse genus consisting of over 2600 serovars responsible for high-burden food- and water-borne gastroenteritis worldwide. Sensitivity and specificity of PCR-based culture-independent diagnostic testing (CIDT) systems for , which depend on a highly conserved gene target, can be affected by single nucleotide polymorphisms (SNPs), indels and genomic rearrangements within primer and probe sequences. This report demonstrates the value of prospectively collected genomic data for verifying CIDT targets. Read More

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http://dx.doi.org/10.1128/JCM.00038-20DOI Listing

Vaccines against gastroenteritis, current progress and challenges.

Gut Microbes 2020 Nov 18;11(6):1486-1517. Epub 2020 Jun 18.

University of Illinois at Urbana-Champaign , Department of Pathobiology, Urbana, Illinois, USA.

Enteric viral and bacterial infections continue to be a leading cause of mortality and morbidity in young children in low-income and middle-income countries, the elderly, and immunocompromised individuals. Vaccines are considered an effective and practical preventive approach against the predominantly fecal-to-oral transmitted gastroenteritis particularly in the resource-limited countries or regions where implementation of sanitation systems and supply of safe drinking water are not quickly achievable. While vaccines are available for a few enteric pathogens including rotavirus and cholera, there are no vaccines licensed for many other enteric viral and bacterial pathogens. Read More

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http://dx.doi.org/10.1080/19490976.2020.1770666DOI Listing
November 2020

[Hemoglobin drop after thrombolytic therapy in a 57-year-old stroke patient with "erosive gastritis"].

Internist (Berl) 2020 Jul;61(7):746-753

Gastroenterologie, Marien-Hospital Euskirchen, Gottfried-Disse-Str. 40, 53879, Euskirchen, Deutschland.

A 57-year-old woman underwent esophagogastroduodenoscopy due to a continuous drop in hemoglobin levels reaching 7.4 g/dl after treatment with intravenous thrombolytic therapy 1 week earlier because of an ischemic insult. Numerous erosive lesions were found in the gastric corpus. Read More

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http://dx.doi.org/10.1007/s00108-020-00818-9DOI Listing

Antibiotic Activity of a -Produced Diketopiperazine against .

J Fungi (Basel) 2020 Jun 10;6(2). Epub 2020 Jun 10.

Dipartimento di Medicina Veterinaria e Produzioni Animali-Università degli Studi di Napoli Federico II, Via Federico Delpino, 1, 80137 Napoli, Italy.

A diketopiperazine has been purified from a culture filtrate of the endophytic fungus , isolated from healthy tissues of strawberry plants in a survey of microbes as sources of anti-bacterial metabolites. Its structure has been determined by nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) analyses and was found to be identical to (L-Pro-L-Phe) purified from species of other fungal genera. This secondary metabolite has been selected following bioguided-assay fractionation against two strains of , the causal agent of bovine gastroenteritis. Read More

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http://dx.doi.org/10.3390/jof6020083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344678PMC

Antimicrobial Resistance Determinants Circulating among Thermophilic Isolates Recovered from Broilers in Ireland Over a One-Year Period.

Antibiotics (Basel) 2020 Jun 8;9(6). Epub 2020 Jun 8.

Department of Biological Sciences, Cork Institute of Technology, Bishopstown, T12 P928 Cork, Ireland.

Campylobacteriosis is the leading cause of human bacterial gastroenteritis, very often associated with poultry consumption. Thermophilic ( and ) isolates ( = 158) recovered from broiler neck skin and caecal contents in Ireland over a one-year period, resistant to at least one of three clinically relevant antimicrobial classes, were screened for resistance determinants. All ciprofloxacin-resistant isolates ( = 99) harboured the C257T nucleotide mutation (conferring the Thr-86-Ile substitution) in conjunction with other synonymous and nonsynonymous mutations, which may have epidemiological value. Read More

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http://dx.doi.org/10.3390/antibiotics9060308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344827PMC

Variability in lag-duration of Campylobacter spp. during enrichment after cold and oxidative stress and its impact on growth kinetics and reliable detection.

Food Res Int 2020 Aug 21;134:109253. Epub 2020 Apr 21.

Food Microbiology, Wageningen University, Bornse Weilanden 9, 6708WG Wageningen, the Netherlands. Electronic address:

Campylobacter jejuni and Campylobacter coli continue to be the leading cause of zoonotic gastroenteritis in the European Union, making reliable detection in food important. Low storage temperatures and atmospheric oxygen concentrations during food production can cause sub-lethal damage or transient non-culturability which is why ISO 10272-1:2017 includes an enrichment step to repair cell damage and increase cell concentrations, thereby supporting detection of campylobacters from foods. The aim of this study was to assess the variability in lag-duration of C. Read More

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http://dx.doi.org/10.1016/j.foodres.2020.109253DOI Listing

Thymol and Carvacrol Downregulate the Expression of Virulence Genes during an In Vitro Infection on Caco-2 Cells.

Microorganisms 2020 Jun 7;8(6). Epub 2020 Jun 7.

DIMEVET, Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia (BO), Italy.

is one of the major bacteria responsible for gastroenteritis in humans caused by foodborne pathogens. As pork is one of the main routes of transmission, bioactive compounds used as feed additives may be an important strategy to control . The aim of this study was to assess the antimicrobial activity of several organic acids and nature identical compounds against ATCC 6994™. Read More

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http://dx.doi.org/10.3390/microorganisms8060862DOI Listing

Unrevealed genetic diversity of GII Norovirus in the swine population of North East Italy.

Sci Rep 2020 Jun 8;10(1):9217. Epub 2020 Jun 8.

Diagnostic Virology Laboratory, Department of Animal Health, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020, Legnaro, Padua, Italy.

Noroviruses (NoVs) are one of the major causative agents of non-bacterial gastroenteritis in humans worldwide. NoVs, belonging to Caliciviridae, are classified into ten genogroups (G) and eight P-groups based on major capsid protein (VP1) and of the RNA-dependent-RNA-polymerase (RdRp), respectively. In swine, the main genogroup and P-group identified are GII and GII. Read More

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http://dx.doi.org/10.1038/s41598-020-66140-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280493PMC

Heavy metal and antibiotic co-resistance in Vibrio parahaemolyticus isolated from shellfish.

Mar Pollut Bull 2020 Jul 22;156:111246. Epub 2020 May 22.

Department of Biological Engineering, Inha University, Incheon, Republic of Korea. Electronic address:

Vibrio parahaemolyticus is a major gastroenteritis-causing pathogen in Korea. Recent studies have reported that heavy metal and antimicrobial resistance in bacteria are related. In this study, we investigated heavy metal and antimicrobial resistance in wild strains of V. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.111246DOI Listing

Antimicrobial activity and acting mechanism of Tegillarca granosa hemoglobin-derived peptide (TGH1) against Vibrio parahaemolyticus.

Microb Pathog 2020 Jun 3;147:104302. Epub 2020 Jun 3.

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Jimei University, 43 Yindou Road, Xiamen, Fujian, 361021, China. Electronic address:

Vibrio parahaemolyticus is a Gram-negative bacterium and the one of leading causal agent of human foodborne diseases such as gastroenteritis upon consumption of raw, or contaminated marine products. There is an increased interest in the use of antimicrobial peptides (AMPs) as alternative food preservatives to prevent foodborne diseases. In this study, bioinformatics tools were used to predict and screen AMPs derived from hemoglobin of blood clam (Tegillarca granosa). Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104302DOI Listing

Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats.

Sci Rep 2020 Jun 4;10(1):9146. Epub 2020 Jun 4.

Université Clermont Auvergne, 3iHP, CNRS, Laboratoire Microorganismes: Génome et Environnement, F-63000, Clermont-Ferrand, France.

Background: Infectious gastroenteritis is a risk factor for the development of post-infectious Irritable Bowel Syndrome (PI-IBS). Recent clinical studies reported a higher prevalence of the intestinal parasite Blastocystis in IBS patients. Using a rat model, we investigated the possible association between Blastocystis infection, colonic hypersensitivity (CHS), behavioral disturbances and gut microbiota changes. Read More

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http://dx.doi.org/10.1038/s41598-020-66156-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272397PMC

Prevalence and antibiotic resistance patterns of isolated from different types of seafood in Selangor, Malaysia.

Saudi J Biol Sci 2020 Jun 16;27(6):1602-1608. Epub 2020 Jan 16.

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor Darul Ehsan, Malaysia.

is a foodborne bacterial pathogen that may cause gastroenteritis in humans through the consumption of seafood contaminated with this microorganism. The emergence of antimicrobial and multidrug-resistant bacteria is another serious public health threat worldwide. In this study, the prevalence and antibiotic susceptibility test of in blood clams, shrimps, surf clams, and squids were determined. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253911PMC

Questing functions and structures of hypothetical proteins from Campylobacter jejuni: a computer-aided approach.

Biosci Rep 2020 Jun;40(6)

Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Bangladesh.

Campylobacter jejuni (C. jejuni) is considered to be one of the most frequent causes of bacterial gastroenteritis globally, especially in young children. The genome of C. Read More

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http://dx.doi.org/10.1042/BSR20193939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284324PMC
June 2020
2.637 Impact Factor

The antibacterial activity of Berberis heteropoda Schrenk and its effect on irritable bowel syndrome in rats.

Chin J Nat Med 2020 May;18(5):356-368

College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

The dried roots of Berberis heteropoda Schrenk have traditionally been used to treat acute gastroenteritis and dysentery. The aim of this study was to confirm the antibacterial activity of an extract of Berberis heteropoda Schrenk rootin vitro and its therapeutic effects on rats with diarrhea-predominant irritable bowel syndrome (D-IBS) in vivo, as well as to identify the related signaling pathways. A water extract of Berberis heteropoda Schrenk root (BHS) inhibited the growth of S. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30042-XDOI Listing

The Reply.

Authors:
Hyoung Chul Park

Am J Med 2020 05;133(5):e209

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http://dx.doi.org/10.1016/j.amjmed.2019.08.021DOI Listing

MRI is Mandatory for the Assignment into Antibiotic Treatment or Appendectomy Group of Patients During Pregnancy.

Am J Med 2020 05;133(5):e208

Cambridge Colorectal Unit, Addenbrooke's University Hospital NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1016/j.amjmed.2019.06.043DOI Listing
May 2020
5.003 Impact Factor

Fatal Clostridium sordellii-mediated hemorrhagic and necrotizing gastroenteropathy in a dog: case report.

BMC Vet Res 2020 May 24;16(1):152. Epub 2020 May 24.

College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Urquhart Building, 464 Bearsden Road, Glasgow, G61 1QH, UK.

Background: Canine hemorrhagic gastroenteritis (also canine gastrointestinal hemorrhagic syndrome) is commonly associated with Clostridium perfringens, although in some cases the etiology remains unclear. This report describes a fatal acute hemorrhagic and necrotizing gastroenteropathy in a dog associated with Clostridium sordellii, a bacterial species never before identified as the etiological agent of hemorrhagic and necrotizing gastroenteropathy in dogs.

Case Presentation: A fully vaccinated, eight-year-old, female neutered Labrador presented with a history of vomiting without diarrhea. Read More

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http://dx.doi.org/10.1186/s12917-020-02362-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245850PMC

Prevalence, antibiotic resistance and genotypes of Campylobacter jejuni and Campylobacter coli isolated from chickens in Irbid governorate, Jordan.

Int J Food Microbiol 2020 Aug 11;327:108656. Epub 2020 May 11.

Veterinary Epidemiology, Economics and Public Health Group, The Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA Hatfield, UK.

Campylobacter is the world's leading cause of bacterial gastroenteritis, causing nearly 9 million cases of food poisoning in Europe every year. Poultry is considered the main source of Campylobacter infection to humans. The objectives of the study were to determine occurrence of C. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108656DOI Listing

Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.

Neurogastroenterol Motil 2020 May 21:e13875. Epub 2020 May 21.

Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background: Recent data substantiate the importance of acute gastroenteritis in the development of irritable bowel syndrome (IBS). An animal model of postinfectious IBS determined the importance of cytolethal distending toxin B (CdtB) during live Campylobacter jejuni infection and its development of autoimmunity to vinculin. In this study, we examine whether subcutaneous exposure to CdtB alone is sufficient to produce the postinfectious IBS effect and autoimmunity. Read More

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http://dx.doi.org/10.1111/nmo.13875DOI Listing

Three Cases of COVID-19 Disease With Colonic Manifestations.

Am J Gastroenterol 2020 06;115(6):948-950

Department of Gastroenterology, Icahn School of Medicine at Mount Sinai-Elmhurst Hospital, Queens, New York, New York, USA.

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http://dx.doi.org/10.14309/ajg.0000000000000692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273932PMC
June 2020
10.755 Impact Factor

In-Silico Proteomic Exploratory Quest: Crafting T-Cell Epitope Vaccine Against Whipple's Disease.

Int J Pept Res Ther 2020 May 18:1-11. Epub 2020 May 18.

Domain of Bioinformatics, School of Bio-Engineering and Bio-Sciences, Lovely Professional University, Punjab, India.

Whipple's disease is one of the rare maladies in terms of spread but very fatal one as it is linked with many disorders (like Gastroenteritis, Endocarditis etc.). Also, current regimens include less effective drugs which require long duration follows up. Read More

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http://dx.doi.org/10.1007/s10989-020-10077-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233679PMC

Antimicrobial Susceptibility Reduction amongst HIV-Infected Individuals at the University Teaching Hospital, Lusaka, Zambia.

Int J Environ Res Public Health 2020 May 12;17(10). Epub 2020 May 12.

Tropical Gastroenterology and Nutrition Group, University Teaching Hospital, Lusaka 10101, Zambia.

Increased antimicrobial resistance among Human Immunodeficiency Virus (HIV)-infected individuals to commonly used antibiotics in the treatment of gastroenteritis is a public health concern, especially in resource-limited settings. We set out to compare the antimicrobial susceptibility pattern of isolates from HIV-infected and HIV-uninfected individuals at a tertiary hospital in Lusaka, Zambia. An analytical cross-sectional study was conducted at the University Teaching Hospital from May 2019 to August 2019. Read More

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http://dx.doi.org/10.3390/ijerph17103355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277298PMC

Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang.

BMC Infect Dis 2020 May 13;20(1):343. Epub 2020 May 13.

School of Laboratory Medicine, Hangzhou Medical College, No. 481, Binwen Road, Hangzhou, Zhejiang, China.

Background: Clostridium difficile infection (CDI) has an increasing pediatric prevalence worldwide. However, molecular characteristics of C. difficile in Chinese children with acute gastroenteritis have not been reported. Read More

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http://dx.doi.org/10.1186/s12879-020-05030-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222317PMC

Describing the Epidemiology of Foodborne Outbreaks in New South Wales from 2000 to 2017.

Foodborne Pathog Dis 2020 May 12. Epub 2020 May 12.

National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, Canberra, Australia.

Foodborne disease causes an estimated 4.1 million cases of illness in Australia each year and is responsible for causing many significant common source outbreaks. We analyzed 18 years of foodborne outbreak data collected in New South Wales (NSW), and classified the likely pathogen type responsible for outbreaks of unknown etiology, to track broad trends over time. Read More

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http://dx.doi.org/10.1089/fpd.2020.2806DOI Listing

Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.

Cell Host Microbe 2020 06 11;27(6):937-949.e6. Epub 2020 May 11.

Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA. Electronic address:

Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce different clinical presentations. Read More

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http://dx.doi.org/10.1016/j.chom.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292776PMC
June 2020
12.328 Impact Factor

Ulcerative reflux esophagitis associated with Clostridium ventriculi following hiatoplasty - is antibiotic treatment necessary? A case report.

Z Gastroenterol 2020 May 11;58(5):456-460. Epub 2020 May 11.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

Clostridium (C.) ventriculi (known as Sarcina ventriculi) is a ubiquitous gram-positive, anaerobic, acidophilic coccus found in patients with gastric motility disorders. The microorganisms can be identified histologically by their characteristic presentation in tetrads or packets of 8 in hematoxylin and eosin stains. Read More

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http://dx.doi.org/10.1055/a-1123-7984DOI Listing

Operative Surgery Is Rarely Required in the Acute Management of Diverticulitis in the Modern Era.

Am Surg 2020 Apr;86(4):308-312

From the *School of Medicine, Griffith University, Gold Coast, Australia and.

Acute diverticulitis is an emergency surgical condition that is commonly managed an acute surgical unit model. Operative surgery is indicated in selected situations including generalized peritonitis or fistulous disease; however, limited data exist on how borderline patients potentially needing surgery may be salvaged by close clinical management with modern interventional techniques. The aims of the study were to identify the operative surgery rates in acute diverticulitis and predictors for identifying patients with complicated diverticulitis. Read More

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Genomic Comparison of Enteritidis Strains Isolated from Laying Hens and Humans in the Abruzzi Region during 2018.

Pathogens 2020 May 5;9(5). Epub 2020 May 5.

Bacteriology and Diary Production Hygiene department, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Campo Boario, 64100 Teramo, Italy.

Salmonellosis is a major cause of bacterial foodborne infection. Since 2016, an increased number of cases of gastroenteritis caused by serovar Enteritidis linked to eggs produced in Poland has been reported in Europe. In Italy, Enteritidis is one of the three most commonly reported serotypes, associated mainly with the consumption of contaminated eggs and derived products. Read More

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http://dx.doi.org/10.3390/pathogens9050349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281747PMC

Proteomics of growth in deoxycholate reveals Cj0025c as a cystine transport protein required for wild-type human infection phenotypes.

Mol Cell Proteomics 2020 May 6. Epub 2020 May 6.

The University of Sydney, Australia

is a major cause of food-borne gastroenteritis. Proteomics by label-based two-dimensional liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) identified proteins associated with growth in 0.1% sodium deoxycholate (DOC, a component of gut bile salts), and system-wide validation was performed by data-independent acquisition (DIA-SWATH-MS). Read More

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http://dx.doi.org/10.1074/mcp.RA120.002029DOI Listing

Scrub typhus as a rare cause of acute pyelonephritis: case report.

BMC Infect Dis 2020 May 6;20(1):322. Epub 2020 May 6.

Global Institute for Interdisciplinary Studies/Gandaki Medical College Teaching Hospital, Post Box: 24560, Sundhara, Kathmandu, Nepal.

Background: Scrub typhus can present with atypical signs and symptoms such as those of acute kidney injury, gastroenteritis, pneumonitis, and acute respiratory distress syndrome. Meningitis, encephalitis, and hepatic dysfunction have also been reported, particularly in severe cases with multisystem involvement. Scrub typhus has never been reported in the literature to cause urinary tract infections (UTIs) which includes cystitis and pyelonephritis. Read More

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http://dx.doi.org/10.1186/s12879-020-05050-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201669PMC

Antibiotics alone as an alternative to appendectomy for uncomplicated acute appendicitis in adults: Changes in treatment modalities related to the COVID-19 health crisis.

J Visc Surg 2020 Jun 24;157(3S1):S33-S42. Epub 2020 Apr 24.

Department of Colorectal surgery, Beaujon Hospital, Paris University, AP-HP, 92110, Clichy, France. Electronic address:

The massive inflow of patients with COVID-19 requiring urgent care has overloaded hospitals in France and impacts the management of other patients. Deferring hospitalization and non-urgent surgeries has become a priority for surgeons today in order to relieve the health care system. It is obviously not simple to reduce emergency surgery without altering the quality of care or leading to a loss of chance for the patient. Read More

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http://dx.doi.org/10.1016/j.jviscsurg.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181971PMC

Gastric lymphoma complicated by phlegmonous gastritis and Guillain-Barré syndrome: A case report.

Medicine (Baltimore) 2020 May;99(18):e20030

Department of Hematology.

Introduction: Complications such as severe infection may occur during the chemotherapy of malignant lymphoma. Phlegmonous gastritis (PG) is a rare acute bacterial infection associated with high mortality, requiring early diagnosis, and prompt management. In addition, Guillain-Barré syndrome (GBS) occasionally requires early treatment and intensive care management due to the occurrence of severe neuropathy and respiratory failure. Read More

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http://dx.doi.org/10.1097/MD.0000000000020030DOI Listing

Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.

Microbiome 2020 04 30;8(1):60. Epub 2020 Apr 30.

Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.

Background: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships. In spite of the plethora of data available on the impact that GI helminths exert on the composition of the gut microflora, whether alterations of microbial profiles are caused by direct parasite-bacteria interactions or, indirectly, by alterations of the GI environment (e.g. Read More

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http://dx.doi.org/10.1186/s40168-020-00818-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193420PMC

Identifying the targets and functions of N-linked protein glycosylation in Campylobacter jejuni.

Mol Omics 2020 Apr 29. Epub 2020 Apr 29.

School of Life and Environmental Sciences, The University of Sydney, 2006, Australia and Charles Perkins Centre, The University of Sydney, Level 4 East, The Hub Building (D17), 2006, Australia. and Discipline of Pathology, School of Medical Sciences, The University of Sydney, 2006, Australia and Sydney Mass Spectrometry, The University of Sydney, 2006, Australia.

Campylobacter jejuni is a major cause of bacterial gastroenteritis in humans that is primarily associated with the consumption of inadequately prepared poultry products, since the organism is generally thought to be asymptomatic in avian species. Unlike many other microorganisms, C. jejuni is capable of performing extensive post-translational modification (PTM) of proteins by N- and O-linked glycosylation, both of which are required for optimal chicken colonization and human virulence. Read More

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http://dx.doi.org/10.1039/d0mo00032aDOI Listing

[Can Uncomplicated Adult Appendicitis Also Be Treated Conservatively?]

Praxis (Bern 1994) 2020 Apr;109(6):465-470

Abteilung für Viszeralchirurgie, Luzerner Kantonsspital, Luzern.

Can Uncomplicated Adult Appendicitis Also Be Treated Conservatively? For more than a century, appendectomy has been the first-line treatment for acute appendicitis. Despite modern imaging, it is not an easy disease to diagnose and is one of the most common emergency procedures worldwide. Conservative therapy for uncomplicated adult appendicitis is increasingly becoming the focus of discussion. Read More

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http://dx.doi.org/10.1024/1661-8157/a003452DOI Listing

In Vitro Effect of the Common Culinary Herb Winter Savory () against the Infamous Food Pathogen .

Foods 2020 Apr 24;9(4). Epub 2020 Apr 24.

Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.

The culinary herb , known as winter savory, is an ingredient of traditional dishes known in different parts of the world. As an ingredient of foods it has the potential to improve their safety. In this study, the herb's activity was investigated against the leading cause of the most prevalent bacterial gastroenteritis worldwide. Read More

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http://dx.doi.org/10.3390/foods9040537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230815PMC

What are the Risk Factors Responsible for the Delay in Diagnosis of Acute Appendicitis in Children? Eleven-year Research from a Single Institution.

Folia Med (Plovdiv) 2019 09;61(3):389-396

Alexandroupolis University Hospital, Democritus University of Thrace, Alexandroupolis, Greece.

Introduction: We conducted a retrospective analysis of 602 children operated on for acute appendicitis (AA) in our department between 1/2007 and 12/2017.

Aim: The aim of this study was to identify factors that are related to a delay in diagnosing AA in children. Furthermore, we’d like to strengthen our previous preliminary results by a) adding gender as a new factor and b) studying a much larger population. Read More

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http://dx.doi.org/10.3897/folmed.61.e39355DOI Listing
September 2019

82 year old male with Right Lower Quadrant Pain.

Ann Emerg Med 2020 05;75(5):576-586

Department of Radiology, Lincoln Medical and Mental Health Center, Bronx, NY.

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http://dx.doi.org/10.1016/j.annemergmed.2019.11.006DOI Listing

Spatial and temporal profiles of enteric viruses in the coastal waters of Tokyo Bay during and after a series of rainfall events.

Sci Total Environ 2020 Jul 6;727:138502. Epub 2020 Apr 6.

Department of Urban Engineering, The University of Tokyo, Tokyo, Japan. Electronic address:

Recreational activities in coastal waters that are polluted by enteric viruses can result in gastroenteritis etc. In this study, the pollution profiles of enteric viruses were examined in the coastal area of Tokyo Bay, Japan, by collecting 57 water samples from three different depths (0.5 m, 3. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138502DOI Listing

Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.

Nat Commun 2020 Apr 24;11(1):2013. Epub 2020 Apr 24.

Junior Research Group Infection Biology of Salmonella, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.

The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and FljB, are methylated at surface-exposed lysine residues by FliB. Read More

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http://dx.doi.org/10.1038/s41467-020-15738-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181671PMC

Antimicrobial resistance of isolates recovered from broilers in the Republic of Ireland in 2017 and 2018: an update.

Br Poult Sci 2020 May 15:1-7. Epub 2020 May 15.

Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.

1. Campylobacteriosis is the leading cause of human bacterial gastroenteritis. Broilers are considered the most important source of human infection. Read More

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http://dx.doi.org/10.1080/00071668.2020.1758300DOI Listing

Induction of neutrophil extracellular traps by Campylobacter jejuni.

Cell Microbiol 2020 Aug 21;22(8):e13210. Epub 2020 May 21.

Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.

Campylobacter jejuni is the leading cause of bacterial-derived gastroenteritis worldwide and can lead to several post-infectious inflammatory disorders. Despite the prevalence and health impacts of the bacterium, interactions between the host innate immune system and C. jejuni remain poorly understood. Read More

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http://dx.doi.org/10.1111/cmi.13210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354212PMC

Taking Control: Binding to Fibronectin Sets the Stage for Cellular Adherence and Invasion.

Front Microbiol 2020 9;11:564. Epub 2020 Apr 9.

School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.

, a foodborne pathogen, is one of the most common bacterial causes of gastroenteritis in the world. Undercooked poultry, raw (unpasteurized) dairy products, untreated water, and contaminated produce are the most common sources associated with infection. establishes a niche in the gut by adhering to and invading epithelial cells, which results in diarrhea with blood and mucus in the stool. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161372PMC