22,940 results match your criteria Gastroenteritis Bacterial


Resistance pattern and maternal knowledge, attitude and practices of suspected Diarrheagenic among children under 5 years of age in Addis Ababa, Ethiopia: cross sectional study.

Antimicrob Resist Infect Control 2018 12;7:110. Epub 2018 Sep 12.

1Department of Microbiology, St. Paul's Hospital Millennium Medical College, P.O.Box 1271, Addis Ababa, Ethiopia.

Background: Diarrheal illness remains one of the leading causes of morbidity and mortality among children under 5 years of age worldwide, especially in developing countries. Diarrheagenic (DEC) is the major cause of gastroenteritis in children in the developing world and is associated with high resistance levels to antibiotics. The aims of this study were to isolate and determine susceptibility patterns of DEC among children under 5 years of age with acute diarrhea and to assess maternal knowledge, attitude and practice towards childhood diarrhea. Read More

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September 2018

Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin.

Front Microbiol 2018 22;9:1906. Epub 2018 Aug 22.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

spp. is one of the main cause of bacterial gastroenteritis in the world. The increase of antibiotic resistance in this species is a threat to public health. Read More

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August 2018
1 Read

Development of a Quantitative PCR Assay for Arcobacter spp. and its Application to Environmental Water Samples.

Microbes Environ 2018 Sep 6. Epub 2018 Sep 6.

Interdisciplinary Center for River Basin Environment, University of Yamanashi.

Arcobacter spp. are emerging pathogens associated with gastroenteritis in humans. The objective of this study was to develop a highly sensitive and broadly reactive quantitative PCR (qPCR) assay for Arcobacter spp. Read More

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September 2018
2.23 Impact Factor

The Involvement of the Gene in Virulence of .

Front Cell Infect Microbiol 2018 20;8:285. Epub 2018 Aug 20.

China MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, China.

is considered as the leading cause of gastroenteritis all over the world. This bacterium has the CRISPR- system, which is used as a gene editing technique in different organisms. However, its role in bacterial virulence has just been discovered; that discovery, however, is just the tip of the iceberg. Read More

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Long-Term Gastrointestinal Consequences are Frequent Following Sporadic Acute Infectious Diarrhea in a Tropical Country: A Prospective Cohort Study.

Am J Gastroenterol 2018 Aug 31. Epub 2018 Aug 31.

Nutrition and Clinical Service Division, International Center for Diarrheal Disease Research, Dhaka, Bangladesh.

Background: Postinfection irritable bowel syndrome (PI-IBS) and functional dyspepsia (PI-FD), though reported from the temperate countries, have not been studied in the tropics; PI-malabsorption syndrome (MAS), which mimics PI-IBS, is reported from the tropics. No report till date on PI-IBS excluded PI-MAS. We studied: (i) the frequency of continuing bowel dysfunction after acute gastroenteritis (AG), (ii) its predictors, and (iii) PI-MAS among patients with PI-IBS. Read More

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August 2018
1 Read

Prevalence of thermotolerant Campylobacter species in dogs and cats in Iran.

Vet Med Sci 2018 Aug 31. Epub 2018 Aug 31.

School of Public Health and Community Development, Maseno University, Maseno, Kenya.

Campylobacter is considered the most common bacterial cause of human gastroenteritis in the world with C. jejuni being regarded as the primary cause of bacterial gastroenteritis. A broad range of other Campylobacter species, including C. Read More

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August 2018
3 Reads

Analysis of frozen strawberries involved in a large norovirus gastroenteritis outbreak using next generation sequencing and digital PCR.

Food Microbiol 2018 Dec 2;76:390-395. Epub 2018 Jul 2.

German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. Electronic address:

Virus-contaminated frozen berries have been frequently identified as cause of foodborne disease outbreaks. To provide new tools for virus detection and characterization in berries, next generation sequencing (NGS) and reverse transcription-digital PCR (RT-dPCR) techniques were tested here with strawberries previously involved in a large-scale norovirus (NoV) gastroenteritis outbreak in Germany. By NGS, about 29 million sequence reads were generated, which mainly showed identities to sequences from the plant matrix and from the bacterial flora. Read More

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December 2018

Aptamer-Based Pathogen Monitoring for ser. Typhimurium.

J Biomed Nanotechnol 2018 Nov;14(11):1992-2002

Salmonella enterica ser. Typhimurium is a foodborne pathogen that causes salmonellosis. Symptoms of salmonellosis include fever, diarrhea, and gastroenteritis. Read More

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November 2018
2 Reads

Non-typhoidal bacteraemia in paediatric leukaemia patients.

Contemp Oncol (Pozn) 2018 14;22(2):105-107. Epub 2018 Jun 14.

Department of Paediatric Haematology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Non-typhoidal (NTS) is an important pathogen that causes gastroenteritis, bacteraemia, and focal infections. Herein, we present our experience with bloodstream infections caused by in paediatric leukaemia patients, which has been reported for the first time in both Europe and the US. According to our research, NTS might be a cause of serious infections in paediatric haematology-oncology patients. Read More

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June 2018
1 Read

Nanoparticle Enhanced Antibody and DNA Biosensors for Sensitive Detection of .

Materials (Basel) 2018 Aug 27;11(9). Epub 2018 Aug 27.

Institute of Chemistry, Technical University of Berlin, Straße des 17. Juni 124, Berlin 10623, Germany.

Bacteria-related pathogenic diseases are one of the major health problems throughout the world. is a genus of rod-shaped Gram-negative enterobacteria of which more than 2600 serotypes have been identified. Infection with can cause salmonellosis, a serious bacterial toxi-infection syndrome associated with gastroenteritis, and paralyphoid and typhoid fevers. Read More

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August 2018
2 Reads
2.65 Impact Factor

Dextran sulfate sodium colitis facilitates colonization with Shiga-toxin producing : A novel murine model for the study of Shiga toxicosis.

Infect Immun 2018 Aug 27. Epub 2018 Aug 27.

Boston University School of Medicine, Department of Pathology and Laboratory Medicine, 670 Albany St. Boston, MA 02118

Shiga toxin-producing (STEC) are globally important gastrointestinal pathogens causing hemorrhagic gastroenteritis with variable progression to potentially fatal Shiga toxicosis. Little is known about potential effects of derived Shiga-like toxins on host gastrointestinal immune responses during infection in part due to lack of a reproducible, immunocompetent animal model of STEC infection without depleting the commensal microbiota.Here we describe a novel and reproducible murine model utilizing dextran sulfate sodium (DSS) colitis to induce susceptibility to colonization with clinical isolate STEC strains. Read More

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August 2018
1 Read

Surveillance for norovirus and enteric bacterial pathogens as etiologies of acute gastroenteritis at U.S. military recruit training centers, 2011-2016.

MSMR 2018 Aug;25(8):8-12

An estimated 179 million cases of acute gastroenteritis (AGE) occur each year in the U.S. and AGE is commonly reported within both training and deployed U. Read More

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Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons.

J Microbiol 2018 Sep 23;56(9):683-689. Epub 2018 Aug 23.

Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.

Human noroviruses are the causative agents of non-bacterial gastroenteritis worldwide. The rapid onset and resolution of disease symptoms suggest that innate immune responses are critical for controlling norovirus infection; however, no effective antivirals are yet available. The present study was conducted to examine the antiviral activities of Schizonepeta tenuifolia Briquet extract (STE) against noroviruses. Read More

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September 2018
3 Reads

Genetic diversity of Campylobacter jejuni and Campylobacter coli isolated from poultry meat products sold on the retail market in Southern Brazil.

Poult Sci 2018 Aug 17. Epub 2018 Aug 17.

Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, 96010-900 Pelotas, RS, Brazil.

Campylobacter is regarded as the most common bacterial cause of gastroenteritis throughout the world and most cases of human campylobacteriosis can be traced back to the consumption of poultry meat. In Brazil, few studies evaluated the genetic relatedness among Campylobacter isolates. The aim of this research was to evaluate the genetic diversity of Campylobacter spp. Read More

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August 2018
1 Read

PLGA-encapsulated CpG ODN and Campylobacter jejuni lysate modulate cecal microbiota composition in broiler chickens experimentally challenged with C. jejuni.

Sci Rep 2018 Aug 13;8(1):12076. Epub 2018 Aug 13.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada.

Campylobacter jejuni is a leading bacterial cause of human gastroenteritis. Reducing Campylobacter numbers in the intestinal tract of chickens will minimize transmission to humans, thereby reducing the incidence of infection. We have previously shown that oral pre-treatment of chickens with C. Read More

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Diagnostic utility of serological biomarkers in patients with Crohn's disease: A case-control study.

Medicine (Baltimore) 2018 Aug;97(32):e11772

Department of Gastroenterology.

The aim of this study was to examine the expression of serological markers in patients with inflammatory bowel disease in China, and determine the diagnostic utility of serological markers, individually and in combination, for the diagnosis and differential diagnosis of Crohn's disease (CD).Serum samples were obtained from 160 participants in Eastern China. Among the participants, 98 were diagnosed with CD, 33 had ulcerative colitis (UC), and 29 were healthy controls (HC). Read More

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August 2018
3 Reads

Effect of Antibiotic-Mediated Microbiome Modulation on Rotavirus Vaccine Immunogenicity: A Human, Randomized-Control Proof-of-Concept Trial.

Cell Host Microbe 2018 Aug;24(2):197-207.e4

Amsterdam UMC, University of Amsterdam, Department of Medicine, Division of Infectious Diseases and Center for Experimental and Molecular Medicine (CEMM), 1105 AZ, Amsterdam, the Netherlands.

Rotavirus vaccines (RVV) protect against childhood gastroenteritis caused by rotavirus (RV) but have decreased effectiveness in low- and middle-income settings. This proof-of-concept, randomized-controlled, open-label trial tested if microbiome modulation can improve RVV immunogenicity. Healthy adults were randomized and administered broad-spectrum (oral vancomycin, ciprofloxacin, metronidazole), narrow-spectrum (vancomycin), or no antibiotics and then vaccinated with RVV, 21 per group per protocol. Read More

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August 2018
1 Read

Investigating the Campylobacter jejuni Transcriptional Response to Host Intestinal Extracts Reveals the Involvement of a Widely Conserved Iron Uptake System.

MBio 2018 Aug 7;9(4). Epub 2018 Aug 7.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada

is a pathogenic bacterium that causes gastroenteritis in humans yet is a widespread commensal in wild and domestic animals, particularly poultry. Using RNA sequencing, we assessed transcriptional responses to medium supplemented with human fecal versus chicken cecal extracts and in extract-supplemented medium versus medium alone. exposed to extracts had altered expression of 40 genes related to iron uptake, metabolism, chemotaxis, energy production, and osmotic stress response. Read More

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[Features of intestinal infections in elderly patients.]

Adv Gerontol 2018 ;31(2):246-249

Kirov State Medical University, 112, Karl Marx str., Kirov, 610998, Russian Federation;

The article compares the flow of intestinal infections in elderly and young people. Analyzed the medical records of 172 persons 60-85 years and 82 history persons 20-40 years with salmonellosis, shigellosis and rotavirus gastroenteritis. It is revealed that bacterial intestinal infections, salmonellosis and shigellosis, those over 60 years of age have the clinical differences and flow is heavier than in patients 20-40 years. Read More

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January 2018
1 Read

High Incidence of Early Human Herpesvirus-6 Infection in Children Undergoing Haploidentical Manipulated Stem Cell Transplantation for Hematologic Malignancies.

Biol Blood Marrow Transplant 2018 Jul 29. Epub 2018 Jul 29.

Pediatric Hematology-Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Human herpesvirus-6 (HHV-6) infection is increasingly recognized among allogeneic hematopoietic stem cell transplantation (HSCT) recipients, with 30% at risk of reactivation in the haploidentical setting. It has been associated with encephalitis, acute graft-versus-host disease, and graft failure. Here we report 2 cohorts of pediatric haploidentical manipulated HSCT in which, despite many differences, HHV-6 reactivation and disease occurred with very high incidence compared with data reported in the literature and represented the main early post-transplant infectious complication compared with other viral, bacterial, or fungal infections. Read More

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July 2018
3 Reads
3.40 Impact Factor

A comparison of the Allplex™ bacterial and viral assays to conventional methods for detection of gastroenteritis agents.

BMC Res Notes 2018 Jul 28;11(1):514. Epub 2018 Jul 28.

Eastern Ontario Regional Laboratory Association, 401 Smyth Rd., Ottawa, ON, K1H 8L, Canada.

Objective: Molecular methods to detect diarrheal pathogens are increasingly being used in place of conventional methods. We compared a new multiplex real-time PCR assay for detection of both bacterial and viral gastroenteritis agents, the Allplex™ Gastrointestinal Panel Assays (AGPA), to conventional methods (stool culture for bacterial pathogens and electron microscopy (EM) for viral pathogens).

Results: Gastrointestinal viruses, in particular norovirus genogroup II viruses, were detected by the AGPA in a high number of specimens that were negative by EM. Read More

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July 2018
1 Read

HELICOBACTER PYLORI INFECTION AND IMMUNE PROFILE OF PATIENTS WITH DIFFERENT GASTRODUODENAL DISEASES.

Arq Gastroenterol 2018 Apr-Jun;55(2):122-127

Universidade Federal do Pará, Laboratório de Patologia Clínica de Doenças Tropicais, Belém, PA, Brasil.

Background: The association between infection with Helicobacter pylori and different gastroduodenal diseases is related to bacterial, host and environmental factors. Studies have demonstrated an association between the genetic diversity of H. pylori, especially in the vacA and cagA genes, and the development of digestive diseases such as peptic ulcer and gastric cancer. Read More

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September 2018
5 Reads

Vibrio parahaemolyticus Senses Intracellular K To Translocate Type III Secretion System 2 Effectors Effectively.

MBio 2018 Jul 24;9(4). Epub 2018 Jul 24.

Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Many Gram-negative bacterial symbionts and pathogens employ a type III secretion system (T3SS) to live in contact with eukaryotic cells. Because T3SSs inject bacterial proteins (effectors) directly into host cells, the switching of secretory substrates between translocators and effectors in response to host cell attachment is a crucial step for the effective delivery of effectors. Here, we show that the protein secretion switch of T3SS2, which is a main contributor to the enteropathogenicity of a food poisoning bacterium, is regulated by two gatekeeper proteins, VgpA and VgpB. Read More

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July 2018
1 Read

Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication.

Front Microbiol 2018 3;9:1466. Epub 2018 Jul 3.

Department of Biotechnology & Bioinformatics, Korea University, Sejong, South Korea.

Norovirus (NoV) is a leading cause of epidemic acute non-bacterial gastroenteritis, and replicates through virion protein genome-linked (VPg)-primed or RNA synthesis by RNA-dependent RNA polymerase (RdRp). VPg is a multifunctional protein that plays crucial roles in viral protein translation and genome replication. However, the interaction between the RdRp and this multifunctional VPg in NoV replication has been unknown. Read More

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July 2018
7 Reads

Structure, function and regulation of the thermostable direct hemolysin (TDH) in pandemic Vibrio parahaemolyticus.

Microb Pathog 2018 Jul 19;123:242-245. Epub 2018 Jul 19.

School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, PR China. Electronic address:

Vibrio parahaemolyticus is a leading cause of seafood-associated bacterial gastroenteritis. The pathogen produces the thermostable direct hemolysin (TDH), which is the sole cause of the Kanagawa phenomenon (KP), a special β-type haemolysis in the Wagatsuma agar. TDH also exerts several other biological activities, the major includes lethal toxicity, cytotoxicity, and enterotoxicity. Read More

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Growth-Inhibitory Effect of d-Tryptophan on Vibrio spp. in Shucked and Live Oysters.

Appl Environ Microbiol 2018 Oct 17;84(19). Epub 2018 Sep 17.

Graduate School of Agricultural Science, Hokkaido University, Sapporo, Japan

and are important human pathogens that are frequently transmitted via consumption of contaminated raw oysters. A small amount of d-tryptophan (d-Trp) inhibits some foodborne pathogenic bacteria in high-salt environments. In this study, we aimed to evaluate the antibacterial effect of d-Trp on and in culture media, artificial seawater, and shucked and live oysters. Read More

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October 2018
4 Reads

Trends in fluoroquinolone resistance in Campylobacter.

Microb Genom 2018 Jan 19;4(1). Epub 2018 Jul 19.

1​The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA27AY, UK.

Members of the genus Campylobacter remain a leading cause of bacterial gastroenteritis worldwide. Infection is usually self-limiting but in severe cases may require antibiotic treatment. In a recent statement by the World Health Organization (WHO) Campylobacter was named as one of the 12 bacteria that pose the greatest threat to human health because they are resistant to antibiotics. Read More

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January 2018

Comparison of automated extraction methods for the detection of hepatitis A virus and norovirus in mussels.

Vet Ital 2018 Jun;54(2):147-153

stituto Zooprofilattico Sperimentale del Mezzogiorno, Animal Health Department, Portici (NA), Italy.

Noroviruses and hepatitis A virus are the pathogens most frequently involved in non-bacterial gastroenteritis and hepatitis worldwide. They are mainly transmitted via the faecal-oral route, direct person-to-person contact or through the consumption of contaminated water and foods. In food virology, detection methods of these viruses are currently based on real-time reverse transcription-polymerase chain reaction (RT-PCR). Read More

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June 2018
1 Read

The Impact of Cold Spells on the Incidence of Infectious Gastroenteritis and Relapse Rates of Inflammatory Bowel Disease: A Retrospective Controlled Observational Study.

Inflamm Intest Dis 2017 Nov 15;2(2):124-130. Epub 2017 Jul 15.

Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Goals: We aimed to assess the impact of very cold days on inflammatory bowel disease (IBD) flares and infectious gastroenteritis (IG). We defined a cold day using the World Meteorological definition of an ice day, which is a day with a maximum temperature below 0°C.

Background: Recently, we have shown that heat waves increase the risk for IG and IBD flares. Read More

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November 2017
3 Reads

Arylamino containing hydroxamic acids as potent urease inhibitors for the treatment of Helicobacter pylori infection.

Eur J Med Chem 2018 Aug 2;156:126-136. Epub 2018 Jul 2.

National Demonstration Center for Experimental Chemistry Education, Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains, Jishou University, Jishou, 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China. Electronic address:

A novel series of aniline-containing hydroxamic acids were designed, synthesized and evaluated as anti-virulence agents for the treatment of gastritis and gastric ulcer caused by Helicobacter pylori. In vitro enzyme-based screen together with in vivo assays and structure-activity relationship (SAR) studies led to the discovery of three potent urease inhibitors 3-(3,5-dichlorophenylamino)N-hydroxypropanamide (3a), 3-(2-chlorophenylamino)N-hydroxypropanamide (3d) and 3-(2,4-dichlorophenylamino)N-hydroxypropanamide (3n). Compounds 3a, 3d and 3n showed excellent urease inhibition with IC values 0. Read More

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August 2018
8 Reads

Azithromycin for Salmonella infection: don't presume it works.

Med J Aust 2018 Jul;209(2):98

PathWest Laboratory Medicine WA, Perth, WA.

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July 2018
4 Reads

Challenges in the early diagnosis of patients with acute liver failure induced by amatoxin poisoning: Two case reports.

Medicine (Baltimore) 2018 Jul;97(27):e11288

Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical College, Guizhou, China.

Rationale: Acute liver failure (ALF) induced by amatoxin-containing mushrooms accounts for more than 90% of deaths in patients suffering from mushroom poisoning. However, due to the fact that most hospitals cannot identify the species of mushrooms involved, or detect amatoxins, the early diagnosis of amatoxin intoxication remains a significant challenge in clinical practice.

Patient Concerns: Two patients were had ingested wild mushrooms 15 hours before admission. Read More

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July 2018
5 Reads

Mouse Norovirus infection reduces the surface expression of MHC class I proteins and inhibits CD8+ T cell recognition and activation.

J Virol 2018 Jul 5. Epub 2018 Jul 5.

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria, Melbourne 3010

Human Noroviruses are highly infectious, single stranded RNA (ssRNA) viruses and the major cause of non-bacterial gastroenteritis worldwide. With the discovery of Murine Norovirus (MNV) and the introduction of an effective model for norovirus infection and replication, knowledge about infection mechanisms and its impact on the host immune response has progressed. A major player in the immune response against viral infections is the group of major histocompatibility complex (MHC) class I proteins, which present viral antigen to immune cells. Read More

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July 2018
9 Reads

Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.

Microb Genom 2018 Jul 5;4(7). Epub 2018 Jul 5.

6​Wellcome Trust Sanger Institute, Hinxton, UK.

Fluoroquinolone (FQ)-resistant Salmonella spp. were listed by the WHO in 2017 as priority pathogens for which new antibiotics were urgently needed. The overall global burden of Salmonella infections is high, but differs per region. Read More

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July 2018
1 Read

[Crohn's Disease - New Therapies].

Dtsch Med Wochenschr 2018 Jul 4;113(13):953-959. Epub 2018 Jul 4.

New promising treatment options for chronic inflammatory bowel diseases, confirm the expanded pathophysiological understanding in terms of the interactions of the gastrointestinal microbiome with the adaptive and innate immune response and barrier protection. Therefore, these interrelations are focus of research and therapeutic strategies. The following review will give insights into the pathomechanisms, current treatment options and future developments. Read More

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July 2018
4 Reads

Novel multiplex PCR assay for identification and subtyping of enteroinvasive Escherichia coli and differentiation from Shigella based on target genes selected by comparative genomics.

J Med Microbiol 2018 Sep 3;67(9):1257-1264. Epub 2018 Jul 3.

1​Centre for Infectious Diseases and Microbiology - Public Health, Institute of Clinical Pathology and Medical Research - NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.

Purpose: Both Shigella and enteroinvasive Escherichia coli (EIEC) can cause enterocolitis, but they have a distinct epidemiology and public health relevance. Current culture-independent testing (CIT) methods to identify Shigella in faecal samples rely on the ipaH gene as the target, which is also found in EIEC genomes. The aim of this study was to design an assay that can identify EIEC in cultures from CIT ipaH-positive samples. Read More

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September 2018
3 Reads

Relationship between enteric pathogens and acute gastroenteritis disease severity: a prospective cohort study.

Clin Microbiol Infect 2018 Jun 28. Epub 2018 Jun 28.

Sections of Pediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Objectives: To evaluate the relationship between individual bacterial and viral pathogens and disease severity.

Methods: Children <18 years with three or more episodes of vomiting and/or diarrhoea were enrolled in two Canadian paediatric emergency departments between December 2014 and August 2016. Specimens were analysed employing molecular panels, and outcome data were collected 14 days after enrolment. Read More

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June 2018
9 Reads

Update on vaccines for enteric pathogens.

Clin Microbiol Infect 2018 Jun 28. Epub 2018 Jun 28.

Bill and Melinda Gates Foundation, Seattle, WA, USA; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Acute diarrhoeal disease caused by viral, bacterial and parasitic infections is a major global health problem; in low- and middle-income countries (LMICs) it is associated with substantial mortality and morbidity in children under 5. Some of these infections also impact large segments of populations in high-income countries (HICs), as well as individuals who travel overseas for work, business or pleasure.

Aims: The aim of this review is to describe the current landscape of licensed enteric vaccines, potential new vaccines on the horizon, and the challenges of development and utilization of vaccines against enteric pathogens. Read More

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June 2018
5 Reads

Antimicrobial resistance profiles of Shigella dysenteriae isolated from travellers returning to the UK, 2004-2017.

J Med Microbiol 2018 Aug 29;67(8):1022-1030. Epub 2018 Jun 29.

Gastrointestinal Bacteria Reference Unit, Public Health England, Colindale, London, UK.

Purpose: Antimicrobial resistance (AMR) profiles of 754 strains of Shigella dysenteriae isolated between 2004 and 2017 from UK travellers reporting symptoms of gastrointestinal (GI) disease were reviewed to look for evidence of emerging AMR associated with travellers' diarrhoea.

Methodology: A travel history was provided for 72.7 % (548/754) of cases, of which 90. Read More

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August 2018
1 Read

An efficient recovery method for enteric viral particles from agricultural soils.

J Virol Methods 2018 Jun 24;261:1-5. Epub 2018 Jun 24.

Agriculture and Agri-Food Canada, Saint-Hyacinthe Research and Development Centre, 3600 Casavant Boulevard West, Saint-Hyacinthe, Quebec J2S 8E3, Canada.

Enteric viruses have been recognized as the leading cause of non-bacterial gastroenteritis and hepatitis outbreaks around the world. Understanding their prevalence and persistence in the environment is important for the effective control of these infections. The aim of this study was to develop an efficient recovery procedure for viral infectious particles from agricultural soils. Read More

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June 2018
2 Reads

Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential.

Emerg Microbes Infect 2018 Jun 26;7(1):116. Epub 2018 Jun 26.

GI Research Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen,, AB25 2ZD, UK.

In recent years, an increasing number of Campylobacter species have been associated with human gastrointestinal (GI) diseases including gastroenteritis, inflammatory bowel disease, and colorectal cancer. Campylobacter concisus, an oral commensal historically linked to gingivitis and periodontitis, has been increasingly detected in the lower GI tract. In the present study, we generated robust genome sequence data from C. Read More

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June 2018
6 Reads

Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections.

Int J Mol Sci 2018 Jun 22;19(7). Epub 2018 Jun 22.

Department of Chemical, Biological, Pharmacological and Environmental Sciences, University of Messina, 31-98166 Messina, Italy.

Acute infectious gastroenteritis (GE) and urinary tract infection (UTI) are common diseases and are normally perceived as mild and limiting illnesses. Xyloglucan is a natural plant polymer with protective barrier properties, also known as “mucosal protectors”, which is the main ingredient of medical devices developed for the management of different diseases, such as gastrointestinal diseases, urinary tract infections, or respiratory allergic diseases. The aim of this study was to evaluate the protective effect of xyloglucan in association with gelose (also called agar) in an experimental model of bacterial GE and UTI in rats. Read More

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Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.

Cell Rep 2018 Jun;23(12):3525-3536

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

Salmonella enterica is an important foodborne pathogen that uses secreted effector proteins to manipulate host pathways to facilitate survival and dissemination. Different S. enterica serovars cause disease syndromes ranging from gastroenteritis to typhoid fever and vary in their effector repertoire. Read More

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June 2018
4 Reads

Superior mesenteric venous thrombosis complicating acute appendicitis: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11168

Department of Internal Medicine, Texas Tech University Health Sciences Center, Odessa, Texas.

Rationale: Superior mesenteric venous thrombosis (SMVT) is a rare condition that carries high mortality. Very few cases have been reported of SMVT, complicating acute appendicitis. Early recognition requires a high index of suspicion and is crucial in successful treatment of such a life-threatening condition. Read More

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June 2018
14 Reads
5.72 Impact Factor

CapC, a Novel Autotransporter and Virulence Factor of Campylobacter jejuni.

Appl Environ Microbiol 2018 Aug 1;84(16). Epub 2018 Aug 1.

Department of Pathology and Infectious Diseases, School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom

is recognized as an important causative agent of bacterial gastroenteritis in the developed world. Despite the identification of several factors contributing to infection, characterization of the virulence strategies employed by remains a significant challenge. Bacterial autotransporter proteins are a major class of secretory proteins in Gram-negative bacteria, and notably, many autotransporter proteins contribute to bacterial virulence. Read More

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Epitope mapping of Salmonella flagellar hook-associated protein, FlgK, with mass spectrometry-based immuno-capture proteomics using chicken (Gallus gallus domesticus) sera.

Vet Immunol Immunopathol 2018 Jul 14;201:20-25. Epub 2018 May 14.

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA; The Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Salmonella, a Gram-negative rod, is the leading foodborne pathogen associated with human acute bacterial gastroenteritis worldwide. The Salmonella flagellum is responsible for bacterial movement, colonization and invasion in the host gastrointestinal tract. The flagellum has a complex structure, composed of more than 35 proteins. Read More

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July 2018
8 Reads

Antimicrobial Resistance in Campylobacter Species: Mechanisms and Genomic Epidemiology.

Adv Appl Microbiol 2018 12;103:1-47. Epub 2018 Feb 12.

U.S. Food and Drug Administration, Laurel, MD, United States.

The Campylobacter genus is a large and diverse group of Gram-negative bacteria that are known to colonize humans and other mammals, birds, reptiles, and shellfish. While it is now recognized that several emerging Campylobacter species can be associated with human disease, two species, C. jejuni and C. Read More

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February 2018
1 Read

Impact of TGEV infection on the pig small intestine.

Virol J 2018 06 19;15(1):102. Epub 2018 Jun 19.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu, 210095, People's Republic of China.

Background: Pig diarrhea causes high mortality and large economic losses in the swine industry. Transmissible gastroenteritis virus (TGEV) causes pig diarrhea, with 100% mortality in piglets less than 2 weeks old. No investigation has yet been made of the small intestine of piglets that survived infection by TGEV. Read More

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June 2018
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Norovirus recombinants: recurrent in the field, recalcitrant in the lab - a scoping review of recombination and recombinant types of noroviruses.

J Gen Virol 2018 Aug 15;99(8):970-988. Epub 2018 Jun 15.

1​Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, FARAH Research Centre, Faculty of Veterinary Medicine, Liège University, B43b, Quartier Vallée 2, Avenue de Cureghem, 10, B-4000 Liège, Belgium.

Noroviruses are recognized as the major global cause of sporadic and epidemic non-bacterial gastroenteritis in humans. Molecular mechanisms driving norovirus evolution are the accumulation of point mutations and recombination. Intragenotypic recombination has long been postulated to be a driving force of GII. Read More

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August 2018
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