214,690 results match your criteria Gastroenteritis Bacterial


Introduction of an Oral Fluid Challenge Protocol in the Management of Children with Acute Gastroenteritis: A Regional Hospital Experience.

Ir Med J 2018 06 7;111(6):775. Epub 2018 Jun 7.

Academic Department of Paediatrics, National University of Ireland, Galway, Ireland

Oral rehydration therapy (ORT) remains the ideal first line therapy for acute gastroenteritis (AGE). Our aim was to assess the impact of introducing an Oral Fluid Challenge (OFC) protocol on outcomes such as intravenous fluid use and documentation in our institution. A single centre study with data collected retrospectively pre-implementation (April 2015) of the OFC protocol and post implementation (April 2016). Read More

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Eosinophil Counts in Mucosal Biopsies of the Ileum and Colon: Interobserver Variance Affects Diagnostic Accuracy.

Patholog Res Int 2018 4;2018:2638258. Epub 2018 Nov 4.

Department of Gastroenterology and Hepatology, University Medical Center Brandenburg, Brandenburg, Germany.

Primary eosinophilic gastroenteritis and colitis (EGE) is a rare entity with unspecific clinical and endoscopic findings. Validated histopathologic criteria for confirming the diagnosis are lacking, because numeric values for normal or elevated concentrations of eosinophils in mucosal biopsies are varying between observers. To quantify this interobserver variance, we had the same set of 30 slides of eosinophilic-rich mucosal biopsies from the ileum and colon systematically reviewed by a panel of six independent pathologists, each with more than a ten-year experience in the field. Read More

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November 2018

Vomiting symptom of acute gastroenteritis estimated from epidemiological data can help predict river contamination by human pathogenic enteric viruses.

Environ Int 2018 Nov 30;123:114-123. Epub 2018 Nov 30.

INRA, UMR 1114 EMMAH, 228 route de l'Aérodrome, CS 40 509, 84914 Avignon Cedex 9, France. Electronic address:

Contamination of fresh water bodies by human enteric viruses from wastewater discharge is a well-established phenomenon. Here we propose a model of viral contamination of rivers based on acute gastroenteritis epidemiology and assess how well it can simulate in situ experimental monitoring. Noroviruses, rotaviruses, enteroviruses, adenoviruses and hepatitis A viruses were quantified by molecular methods after water concentration. Read More

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November 2018

Introduction of rotavirus vaccination in a Swedish region: assessing parental decision-making, obtained vaccination coverage and resulting hospital-admissions.

Acta Paediatr 2018 Dec 2. Epub 2018 Dec 2.

Department of Paediatrics, Jönköping, Region Jönköping County, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Aim: This study evaluated the introduction of rotavirus vaccination in Jönköping County, Sweden, starting in 2014. This project explored the parental factors that influenced the decision to vaccinate and studied the obtained vaccination coverage and its potential influence on hospital admissions due to acute gastroenteritis.

Methods: This was a descriptive, cross-sectional study based on a study specific questionnaire (n=356) and regional statistical data on vaccination coverage and hospital admissions in Jönköping County, Sweden. Read More

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December 2018

Trials with the Haemonchus vaccine, Barbervax, in ewes and lambs in a tropical environment: Nutrient supplementation improves protection in periparturient ewes.

Vet Parasitol 2018 Dec 8;264:52-57. Epub 2018 Nov 8.

UNESP - Universidade Estadual Paulista, Departamento de Parasitologia, Instituto de Biociências, Botucatu, SP, CEP 18.618-689, Brazil.

Haemonchus contortus is an economic problem in sheep farms worldwide, mainly in the tropics and subtropics. A vaccine against haemonchosis, called Barbervax, was evaluated in ewes under two nutritional status, naturally infected with gastrointestinal nematodes. Ewes were divided into four groups: Supplemented Diet - Vaccine; Supplemented Diet - No vaccine; Basal Diet - Vaccine and Basal Diet - No vaccine. Read More

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December 2018

Inpatient treatment of trekkers and Nepalese workers in the high-altitude environment of region 1996-2011: A retrospective analysis.

Travel Med Infect Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Occupational, Social and Environmental Medicine, RWTH Aachen University, Aachen, Germany; Department of Dental Preservation, Parodontology& Preventive Dentistry, RWTH Aachen Technical University, Aachen, Germany. Electronic address:

Background: The study investigates the diagnoses of inpatients (tourists and Nepali workers) of Kunde Hospital (Mt.Everest region) over 15 years.

Methods: Records from January 1996 to September 2011 were analyzed concerning date, gender, age group, nationality, purpose of visit, diagnosis, length of treatment, and condition at discharge. Read More

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November 2018

Minimally Invasive Saliva Testing to Monitor Norovirus Infection in Community Settings.

J Infect Dis 2018 Dec 5. Epub 2018 Dec 5.

Departments of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore.

Background: Norovirus is a leading cause of acute gastroenteritis worldwide. Routine norovirus diagnosis requires stool collection. The goal of this study was to develop and validate a noninvasive method to diagnose norovirus to complement stool diagnostics and to facilitate studies on transmission. Read More

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December 2018
2 Reads

Performance of Stool Testing Recommendations for Acute Gastroenteritis when Used to Identify Children with Nine Potential Bacterial Enteropathogens.

Clin Infect Dis 2018 Dec 4. Epub 2018 Dec 4.

Sections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The ability to identify bacterial pathogens that necessitate specific clinical management or public health action in children with acute gastroenteritis is crucial to patient care and public health. However, existing stool testing guidelines offer inconsistent recommendations, and their performance characteristics are unknown. We evaluated six leading gastroenteritis guidelines (e. Read More

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December 2018
5 Reads

Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis.

PLoS One 2018 5;13(12):e0207701. Epub 2018 Dec 5.

Department of Health Research Methods, Evidence & Impact; McMaster University, Hamilton, Canada.

Background: Many interventions have shown effectiveness in reducing the duration of acute diarrhea and gastroenteritis (ADG) in children. Yet, there is lack of comparative efficacy of interventions that seem to be better than placebo among which, the clinicians must choose. Our aim was to determine the comparative effectiveness and safety of the pharmacological and nutritional interventions for reducing the duration of ADG in children. Read More

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December 2018
1 Read

Diarrheagenic Associated with Acute Gastroenteritis in Children from Soriano, Uruguay.

Can J Infect Dis Med Microbiol 2018 24;2018:8387218. Epub 2018 Oct 24.

Bacteriology and Virology Department, Hygiene Institute, Medicine Faculty, Universidad de la República, Uruguay.

Introduction: Acute diarrheal disease still deserves worldwide attention due to its high morbidity and mortality, especially in developing countries. While etiologic determination is not mandatory for management of all individual cases, it is needed for generating useful epidemiologic knowledge. Diarrheagenic (DEC) are relevant enteropathogens, and their investigation requires specific procedures to which resources and training should be dedicated in reference laboratories. Read More

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October 2018
2 Reads

Estimated Annual Deaths, Hospitalizations, and Emergency Department and Physician Office Visits from Foodborne Illness in Ontario.

Foodborne Pathog Dis 2018 Dec 4. Epub 2018 Dec 4.

1 Public Health Ontario , Toronto, Canada .

Public Health Ontario is working to estimate the burden of disease from environmental hazards in Ontario, Canada. As part of this effort, we estimated deaths and health care utilization resulting from exposure to pathogens and toxic substances in food. We applied fractions for the proportion of illness attributable to foodborne transmission to the annual (2008-2012) counts of deaths, hospitalizations, emergency department (ED) visits, and physician office visits for 15 diseases (13 pathogen-specific diseases and 2 nonspecific syndromes) captured by administrative health data. Read More

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December 2018

Rotavirus infections in children in Turkey: A systematic review.

Rev Med Virol 2018 Dec 4:e2020. Epub 2018 Dec 4.

Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey.

We aimed to describe rotavirus epidemiology and clinical findings including extraintestinal manifestations in a setting that has yet to introduce rotavirus vaccines in the national immunization program. A literature search was performed by using the key words "Turkey" and "rotavirus." Ninety-eight studies published between 1987 and 2016 including epidemiological, clinical, and genotypical data at least 1 year duration were included. Read More

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December 2018

A SUMOylation dependent switch of Rab7 governs intracellular life and pathogenesis of Typhimurium.

J Cell Sci 2018 Dec 3. Epub 2018 Dec 3.

Regional Centre for Biotechnology, 3 milestone Gurgaon Faridabad Expressway, Faridabad, 121001, India

Typhimurium (ST) is an intracellular pathogen that causes gastroenteritis in humans. Aided by a battery of effector proteins, ST resides intracellularly in a specialized vesicle, called -containing vacuole (SCV) that utilizes the host endocytic vesicular-transport pathway (VTP). Here we probed the possible role of SUMOylation, a post-translation modification pathway, in SCV biology. Read More

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December 2018

Estimating the incidence of norovirus acute gastroenteritis among US and European international travelers to areas of moderate to high risk of traveler's diarrhea: a prospective cohort study protocol.

BMC Infect Dis 2018 Dec 3;18(1):605. Epub 2018 Dec 3.

University of Texas McGovern Medical School and School of Public Health, 1200 Pressler Street, Houston, TX, 77030, USA.

Background: Acute gastroenteritis (AGE) is the leading cause of illness among returning travelers seeking medical care. Multiple types of enteric pathogens can cause travel-acquired AGE and, while bacterial pathogens have a predominant role, the importance of viruses, such as norovirus, is increasingly recognized. There is a lack of information on travel-acquired norovirus incidence among symptomatic and asymptomatic individuals irrespective of healthcare-seeking behavior. Read More

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December 2018

Prolonged duodenal mucosal lymphocyte alterations in patients with and without post infectious functional gastrointestinal disorders after Giardia infection.

J Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Objective: Persisting low grade inflammation is suggested to play a role in post-infectious functional gastrointestinal disorders (PI-FGID). The present study examined alterations in duodenal mucosal lymphocytes during and after Giardia gastroenteritis in patients who did, or did not, develop PI-FGID.

Design: Duodenal mucosal intraepithelial lymphocytes (IELs) and lamina propria CD3, CD4, CD8 and CD20 lymphocytes were quantified in 28 chronic giardiasis (CG) patients, 66 patients with persistent abdominal symptoms after acute Giardia infection (PI-FGID), 19 recovered controls (RC) and 16 healthy volunteers (HC). Read More

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November 2018
1 Read

Prevalence of Clostridium perfringens netE and netF toxin genes in the feces of dogs with acute hemorrhagic diarrhea syndrome.

J Vet Intern Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Veterinary Medicine, Clinic of Small Animal Internal Medicine, Ludwig Maximilian University of Munich, Munich, Germany.

Background: Recently, novel pore-forming toxin genes designated netE and netF were identified in a Clostridium perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea.

Objectives: Pore-forming toxins could play an important role in the disease pattern of acute hemorrhagic diarrhea syndrome (AHDS) in dogs. Thus, we aimed to determine the prevalence of C. Read More

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November 2018

Passive surveillance of rotavirus gastroenteritis-associated hospitalization using nationwide administrative databases in Japan.

J Infect Chemother 2018 Nov 26. Epub 2018 Nov 26.

Kawasaki City Institute for Public Health, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-0821, Japan. Electronic address:

Simple, systematic, and sustainable passive surveillance systems for vaccine-preventable diseases (VPDs) should be useful to quantify the clinical and economic burden in a timely manner with minimum investment. This pilot study evaluated the usefulness of nationwide administrative databases (a hospital-based administrative database and an insurance claims database) for such passive surveillance of children hospitalized for VPDs using rotavirus gastroenteritis (RGE) as an example. Two rotavirus vaccines were launched in November 2011 and July 2012 in Japan. Read More

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November 2018
1 Read

A global bibliometric analysis of Plesiomonas-related research (1990 - 2017).

PLoS One 2018 29;13(11):e0207655. Epub 2018 Nov 29.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, Eastern Cape, South Africa.

Plesiomonas shigelloides is an emerging pathogen with damaging effects on human health such as gastroenteritis and extraintestinal infections. Here, we carried out a bibliometric survey that aimed to examine publication trends in Plesiomonas-related research by time and place, international collaborative works, identify gaps and suggest directions for future research. The search term "Plesiomonas shigelloides" was used to retrieve articles published between 1990 and 2017 from the Web of Science database. Read More

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November 2018

Things Are Not Always What They Seem: Two Cases of Child Maltreatment Presenting With Common Pediatric Chief Complaints.

Pediatr Emerg Care 2018 Nov 26. Epub 2018 Nov 26.

Hospital Medicine, Department of Pediatrics, and.

We describe 2 cases of child maltreatment who presented as common pediatric conditions: preseptal cellulitis and gastroenteritis. The first case is an 8-year-old girl who presented with progressive right eye pain, swelling, and discharge. She was initially treated for preseptal cellulitis, but eye cultures ultimately grew Neisseria gonorrhoeae. Read More

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November 2018

Electrophoretic Patterns of Human Rotavirus Strain Prevailing Among Children.

Mymensingh Med J 2018 Oct;27(4):679-684

Dr Samsoon Nahar, M Phil Thesis Part Student, Department of Microbiology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh.

Rotavirus gastroenteritis is a major cause of severe dehydrating diarrhea in children worldwide. Group A rotavirus causes approximately 40% of hospitalization for diarrhea among under 5 years children. Polyacrylamide gel electrophoresis (PAGE) and silver staining was applied to detect rotavirus dsRNA from acute diarrheic stool of 776 hospitalized children below five years. Read More

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October 2018

Serovar Typhimurium Travels to Mesenteric Lymph Nodes Both with Host Cells and Autonomously.

J Immunol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.

infection is a globally important cause of gastroenteritis and systemic disease and is a useful tool to study immune responses in the intestine. Although mechanisms leading to immune responses against have been extensively studied, questions remain about how bacteria travel from the intestinal mucosa to the mesenteric lymph nodes (MLN), a key site for Ag presentation. In this study, we used a mouse model of infection with serovar Typhimurium (STM) to identify changes in intestinal immune cells induced during early infection. Read More

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November 2018

Improving Our Understanding of Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain.

mSphere 2018 Nov 28;3(6). Epub 2018 Nov 28.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

Enteric fever is caused by three serovars: Typhi, Paratyphi A, and Paratyphi B Although vaccines against two of these serovars are licensed (Typhi) or in clinical development (Paratyphi A), as yet there are no candidates for Paratyphi B. To gain genomic insight into these serovars, we sequenced 38 enteric fever-associated strains from Chile and compared these with reference genomes. Each of the serovars was separated genomically based on the core genome. Read More

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November 2018

EGFR as a Negative Regulatory Protein Adjusts the Activity and Mobility of NHE3 in the Cell Membrane of IPEC-J2 Cells With TGEV Infection.

Front Microbiol 2018 13;9:2734. Epub 2018 Nov 13.

Department of Veterinary Medicine, Southwest University, Chongqing, China.

Transmissible gastroenteritis (TGE) has caused devastating economic losses to the swine industry worldwide, despite extensive research focusing on the pathogenesis of virus infection. The molecular pathogenic mechanism of TGEV-induced diarrhea in piglets is unknown. Intestinal diarrhea is closely related to the function of the Na/H exchanger protein NHE3 in the brush border membrane of small intestine epithelial cells. Read More

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November 2018
3.940 Impact Factor

Epidemiologic challenges in norovirus vaccine development.

Hum Vaccin Immunother 2018 Nov 27. Epub 2018 Nov 27.

a Division of Viral Diseases , Centers for Disease Control and Prevention , Atlanta , GA , USA.

Norovirus is the leading cause of acute gastroenteritis (AGE) worldwide. In the United States norovirus is estimated to cause 19-21 million illnesses, 1.7-1. Read More

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November 2018
2 Reads

Conurbation, Urban, and Rural Living as Determinants of Allergies and Infectious Diseases: Royal College of General Practitioners Research and Surveillance Centre Annual Report 2016-2017.

JMIR Public Health Surveill 2018 Nov 26;4(4):e11354. Epub 2018 Nov 26.

Royal College of General Practitioners Clinical Innovation and Research Centre, London, United Kingdom.

Background: Living in a conurbation, urban, or rural environment is an important determinant of health. For example, conurbation and rural living is associated with increased respiratory and allergic conditions, whereas a farm or rural upbringing has been shown to be a protective factor against this.

Objective: The objective of the study was to assess differences in general practice presentations of allergic and infectious disease in those exposed to conurbation or urban living compared with rural environments. Read More

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November 2018
2 Reads

[The importance of epidemiological surveillance of emerging enteroviruses].

An Pediatr (Barc) 2018 Nov 23. Epub 2018 Nov 23.

Unidad de Enterovirus y Gastroenteritis Víricas, Laboratorio de Referencia e Investigación en Enfermedades Víricas Inmunoprevenibles, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda (Madrid), España.

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November 2018

The correlation between family food handling behaviors and foodborne acute gastroenteritis: a community-oriented, population-based survey in Anhui, China.

BMC Public Health 2018 Nov 26;18(1):1290. Epub 2018 Nov 26.

School of public health, Wannan Medical College, 22 West Wenchang Road, Wuhu, 241002, Anhui Province, China.

Background: Foodborne acute gastroenteritis is a significant public health concern. Food handling plays a key role in the risk of foodborne acute gastroenteritis. However, research focused on the correlation between foodborne acute gastroenteritis and food handling in the family environment is limited. Read More

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November 2018

Etiologic and clinical characterization of community acquired gastroenteritis in adult patients in a Chilean emergency room by the FilmArray GI panel.

PLoS One 2018 26;13(11):e0207850. Epub 2018 Nov 26.

Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Infectious diarrhea can be caused by a large number of microorganisms including bacteria virus and parasites. The clinical syndromic approach has been traditionally used to guide therapy. The aim of this study was to characterize the etiology of acute diarrhea by the FilmArray GI panel and to correlate it with its clinical presentation in an adult population presenting to the emergency room in a developing country. Read More

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November 2018
2 Reads

A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.

J Vis Exp 2018 Nov 7(141). Epub 2018 Nov 7.

State Key Laboratory of Diarrhea Disease Detection, Zhuhai International Travel Healthcare Center;

Fecal-oral transmission of acute gastroenteritis occurs from time to time, especially when people who handled food and water are infected by Salmonella spp./Shigella spp. The gold standard method for the detection of Salmonella spp. Read More

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November 2018
2 Reads

Enhanced colorimetric detection of norovirus using in-situ growth of Ag shell on Au NPs.

Biosens Bioelectron 2018 Nov 1;126:425-432. Epub 2018 Nov 1.

Department of Applied Biological Chemistry, College of Agriculture, Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan; Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan. Electronic address:

Norovirus (NoV) is a leading cause of acute gastroenteritis. The low infectious dose and environmental stability of NoV facilitate its effective transmission through a variety of modes such as food, water and person-to-person. The available enzyme-linked immunosorbent assay (ELISA) for NoV detection has low sensitivity due to the low catalytic activity of the peroxidase used, and thus, a reliable ultrasensitive bioassay is needed. Read More

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November 2018
2 Reads

Molecular characterization of rotavirus diarrhea among children aged under five years in the Philippines, 2013-2015.

Vaccine 2018 Dec 19;36(51):7888-7893. Epub 2018 Nov 19.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

With the availability of new and existing rotavirus vaccines, credible and reliable data on burden of rotavirus-associated disease are needed to enable evidence-based decision making regarding the introduction of rotavirus vaccines. The national rotavirus surveillance program in the Philippines, a sentinel-based surveillance, was established in 2012 to determine the proportion of laboratory-confirmed rotavirus cases among children under five years with acute gastroenteritis and to describe the geographic distribution and molecular epidemiology of rotavirus in the country. During 2013 to 2015, rotavirus infection was the cause of acute gastroenteritis among children under five years admitted to hospitals or evaluated in emergency rooms, constituting more than one-third of gastroenteritis hospitalizations at the sentinel site hospitals. Read More

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December 2018
9 Reads

Prevalence, serotypes, and drug resistance of nontyphoidal Salmonella among paediatric patients in a tertiary hospital in Guangzhou, China, 2014-2016.

J Infect Public Health 2018 Nov 19. Epub 2018 Nov 19.

Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:

Purpose: Nontyphoidal Salmonella (NTS) is a common pathogen responsible for acute gastroenteritis among all ages; however, information on the prevalence, serotypes, and antibiotic susceptibility of NTS isolates is limited. We aimed to explore the characteristics of NTS isolated from paediatric patients in Guangzhou, China.

Methods: This was a retrospective study of 4586 stool culture collected at Guangzhou Women and Children's Medical Center from 2014 to 2016. Read More

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November 2018
1 Read

Efficacy of gelatin tannate for acute diarrhea in children: a systematic review and meta-analysis.

J Comp Eff Res 2018 Nov 22. Epub 2018 Nov 22.

Pediatric Gastroenterology & Liver Unit, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Aim: To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis.

Methods: A comprehensive literature search was conducted. Studies were selected according to PICO: Participants: children aged 0-12 years with acute diarrhea; Intervention: GT; Comparison: oral rehydration solution and/or placebo; Outcomes: diarrhea-related outcomes. Read More

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November 2018
4 Reads

Early Infection of Porcine Sapovirus Disrupts Tight Junction and Uses Occludin as a Co-receptor.

J Virol 2018 Nov 21. Epub 2018 Nov 21.

Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea

is a genus in the family, and its members are common causative agents of severe, acute gastroenteritis in both humans and animals. Some caliciviruses are known to use either terminal sialic acids or histo-blood group antigens as attachment factors and/or cell surface proteins such as CD300lf, CD300ld, and junctional adhesion molecule 1 of tight junctions (TJs) as receptors. However, the role of TJs and their proteins in sapovirus entry has not been examined. Read More

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November 2018
1 Read

Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis.

N Engl J Med 2018 11;379(21):2015-2026

From the Sections of Pediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital, Alberta Children's Hospital Research Institute (S.B.F.), and the Section of Pediatric Emergency Medicine, Alberta Children's Hospital (S.W.-U., J.X.), Cumming School of Medicine, University of Calgary, Calgary, the Departments of Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa (K.J.F.), the Division of Pediatric Emergency Medicine, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal (S.G.), Ontario Child Health Support Unit, SickKids Research Institute, the Division of Biostatistics, Dalla Lana School of Public Health (A.R.W.), the Division of Gastroenterology, Hepatology, and Nutrition (P.M.S.), the Divisions of Pediatric Emergency Medicine and Clinical Pharmacology and Toxicology (Y.F.), and the Division of Pediatric Emergency Medicine and Research Institute (S.S.), Hospital for Sick Children, University of Toronto, Toronto, the Division of Emergency Medicine, London Health Sciences Centre, Department of Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON (N.P.), the Division of Pediatric Emergency Medicine, IWK Health Centre, Halifax, NS (K.H.), the Department of Pediatrics, Faculty of Medicine and Dentistry, Women and Children's Health Research Institute (B.E.L.) and the Provincial Laboratory for Public Health-Alberta Public Laboratories and Department of Laboratory Medicine and Pathology (X.-L.P., L.C.), University of Alberta, Edmonton - all in Canada; the Division of Pediatric Emergency Medicine, Washington University School of Medicine, St. Louis (D.S.); and Children's Minnesota and Department of Pediatrics, University of Minnesota Medical School, Minneapolis (M.G.).

Background: Gastroenteritis accounts for approximately 1.7 million visits to the emergency department (ED) by children in the United States every year. Data to determine whether the use of probiotics improves outcomes in these children are lacking. Read More

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November 2018
21 Reads

Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children.

N Engl J Med 2018 11;379(21):2002-2014

From the Divisions of Pediatric Emergency Medicine (D.S., V.P.D.) and Gastroenterology, Hepatology, and Nutrition (P.I.T., C.H.-M.), Department of Pediatrics, Washington University School of Medicine, St. Louis; the Department of Pediatrics, University of Utah, Salt Lake City (T.C.C., J.M.D., C.S.O., M.M.); Central Administration, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis (M.H.G.); the Division of Emergency Medicine, Children's National Health System, Department of Pediatrics, George Washington School of Medicine and Health Sciences, Washington, DC (K.J.O.); the Division of Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit (P.M.); the Departments of Emergency Medicine and Pediatrics, University of Michigan, Ann Arbor (P.M., A.J.R.); the Department of Emergency Medicine, Rhode Island Hospital/Hasbro Children's Hospital and Brown University, Providence (A.C.L.); the Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati (D.S., S.R.B.); the Division of Emergency Medicine, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York (C.G.R.); the Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago (E.C.P.); the Departments of Emergency Medicine and Pediatrics, University of California Davis School of Medicine, Sacramento (C.V.); the Department of Emergency Medicine, University of New Mexico, Albuquerque (R.E.S.); and the Sections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada (S.B.F.).

Background: Acute gastroenteritis develops in millions of children in the United States every year, and treatment with probiotics is common. However, data to support the use of probiotics in this population are limited.

Methods: We conducted a prospective, randomized, double-blind trial involving children 3 months to 4 years of age with acute gastroenteritis who presented to one of 10 U. Read More

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November 2018
11 Reads
55.870 Impact Factor

Probiotics for Children with Gastroenteritis.

Authors:
J Thomas LaMont

N Engl J Med 2018 11;379(21):2076-2077

From the Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston.

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November 2018

Characterization and CRISPR-based genotyping of clinical -positive .

Gut Pathog 2018 13;10:48. Epub 2018 Nov 13.

1Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand.

Background: is a causative agent of gastroenteritis. Most of the clinical isolates carry either and/or genes which are considered as the major virulence genes of this pathogen. In this study, the clinical isolates of carrying gene (= 73) obtained from 1886 to 2012 from various countries were investigated for the urease production, haemolytic activity, and biofilm formation. Read More

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November 2018
4 Reads

Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting.

Am J Trop Med Hyg 2018 Nov 19. Epub 2018 Nov 19.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

Cryptosporidiosis is commonly described as a cause of gastroenteritis syndrome in the organ transplant population, mainly in high-prevalence settings, with stool microscopy as the predominant diagnostic modality. Therapeutic options in this group of patients are limited, making their management exceptionally challenging. We describe a case of a renal transplant recipient with cryptosporidiosis confirmed by the stool FilmArray gastrointestinal panel (GIP) nucleic acid-based assay and stool microscopy, describe our institutional experience in diagnosing cryptosporidiosis in a low-prevalence setting, and review the available literature on management of this condition in the organ transplant population. Read More

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November 2018
7 Reads

Consortium for Eosinophilic Researchers (CEGIR): Advancing the Field of Eosinophilic GI Disorders Through Collaboration.

Gastroenterology 2018 Nov 16. Epub 2018 Nov 16.

Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine/Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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November 2018
2 Reads

Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells.

Sci Rep 2018 Nov 19;8(1):16996. Epub 2018 Nov 19.

Department of Molecular Biology, Umeå University, 90187, Umea, Sweden.

Campylobacter jejuni is a prevalent human pathogen and a major cause of bacterial gastroenteritis in the world. In humans, C. jejuni colonizes the intestinal tract and its tolerance to bile is crucial for bacteria to survive and establish infection. Read More

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November 2018
3 Reads

Paediatric deaths in a tertiary government hospital setting, Malawi.

Paediatr Int Child Health 2018 Nov 19:1-9. Epub 2018 Nov 19.

g Centre for Medical Education , Queen's University , Belfast , UK.

Background: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

Aims: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. Read More

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November 2018
5 Reads

Human astroviruses: in silico analysis of the untranslated region and putative binding sites of cellular proteins.

Mol Biol Rep 2018 Nov 17. Epub 2018 Nov 17.

ENMH, Programa Institucional de Biomedicina Molecular, Instituto Politécnico Nacional, Guillermo Massieu Helguera No. 239 Col. Fracc. La Escalera-Ticomán, 07320, Ciudad de Mexico, Mexico.

Human astrovirus (HAstV) constitutes a major cause of acute gastroenteritis in children. The viral 5' and 3' untranslated regions (UTR) have been involved in the regulation of several molecular mechanisms. However, in astrovirues have been less characterized. Read More

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November 2018
1 Read

The burden of gastroenteritis in Switzerland (BUGS) study: a research proposal for a 1-year, prospective cohort study.

BMC Res Notes 2018 Nov 16;11(1):816. Epub 2018 Nov 16.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Objectives: Acute gastroenteritis (AG) is a usually self-limiting, but common disease worldwide. In Europe, incidence estimates range from 0.3-1. Read More

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November 2018
4 Reads

Multidisciplinary Investigations on : A Mexican Medicinal Plant with Pharmacological Potential.

Molecules 2018 Nov 15;23(11). Epub 2018 Nov 15.

Centro de Investigación en Biotecnología (CEIB), Universidad Autónoma del Estado de Morelos (UAEM), Cuernavaca CP 62209, Mexico.

(Cav.) Kuntze is an important endemic plant species, which possesses many medicinal properties and has been used in the Mexican traditional medicine for its sedative, anxiolytic, anticonvulsant, antiasthmatic and antiallergic properties. The therapeutic properties of this plant are mainly due to the presence of diverse bioactive compounds such as flavonoids, triterpenoids, and phenolics. Read More

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November 2018
5 Reads
2.420 Impact Factor

Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis.

Viruses 2018 Nov 15;10(11). Epub 2018 Nov 15.

Institute of Microbiology and Virology, Rīga Stradiņš University, 5 Ratsupites St., LV-1067 Riga, Latvia.

Human bocaviruses (HBoVs) 1⁻4 belong to the Parvoviridae family, and they infect the respiratory or gastrointestinal tracts in children. We investigated the prevalence of HBoV1⁻4 DNAs in the blood and stool samples, and of HBoV1⁻4 IgG and IgM in the plasma samples, of children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections with the five most frequent gastrointestinal pathogens. Read More

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November 2018
2 Reads

The Norovirus Epidemiologic Triad: Predictors of Severe Outcomes in US Norovirus Outbreaks, 2009-2016.

J Infect Dis 2018 Nov 15. Epub 2018 Nov 15.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Atlanta, Georgia.

Background: Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. Clarifying the viral, host, and environmental factors (epidemiologic triad) associated with severe outcomes can help target public health interventions.

Methods: Acute norovirus outbreaks reported to the National Outbreak Reporting System (NORS) in 2009-2016 were linked to laboratory-confirmed norovirus outbreaks reported to CaliciNet. Read More

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November 2018