23,316 results match your criteria Gastroenteritis Bacterial


Genome characterization and temporal evolution analysis of a non-epidemic norovirus variant GII.8.

Infect Genet Evol 2019 Feb 15;70:15-23. Epub 2019 Feb 15.

Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China. Electronic address:

Noroviruses are the primary cause of non-bacterial acute gastroenteritis worldwide, and GII.8 belongs to a non-epidemic genotype with a limited understanding currently. In this study, we assembled the first GII. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.010DOI Listing
February 2019

Comparative Evaluation of Seegene Allplex Gastrointestinal, Luminex xTAG Gastrointestinal Pathogen Panel, and BD MAX Enteric Assays for Detection of Gastrointestinal Pathogens in Clinical Stool Specimens.

Arch Pathol Lab Med 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea (Drs Yoo, J. Park, H. K. Lee, and Y.-J. Park); the Department of Laboratory Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea (Mss Yu and K. G. Park and Mr G. D. Lee); and the Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge (Ms Oak).

Context.—: Infectious gastroenteritis is caused by various pathogens, including bacteria, viruses, and parasites.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0002-OADOI Listing
February 2019
1 Read

An Abdominal Aortic Aneurysm, Intramural Thrombus and Moderate Leak in an Asian Man Presenting with Acute Gastroenteritis.

Eur J Case Rep Intern Med 2018 31;5(1):000758. Epub 2018 Jan 31.

Emergency Department, IMC Hospital, Jeddah, Saudi Arabia.

Introduction: Missing a leaking abdominal aortic aneurysm (AAA) is common in medical practice because few at-risk patients have a history of AAA and many have an unusual presentation.

Background: AAA is less common among Asians than white Caucasians of the same age. Our patient had no significant risk factors apart from age and sex and had an unusual presentation. Read More

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http://dx.doi.org/10.12890/2017_000759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346940PMC
January 2018
1 Read

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
1 Read

Differentiating Acute Food Protein-Induced Enterocolitis Syndrome From Its Mimics: A Comparison of Clinical Features and Routine Laboratory Biomarkers.

J Allergy Clin Immunol Pract 2019 Feb 25;7(2):471-478.e3. Epub 2018 Oct 25.

Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Background: Food protein-induced enterocolitis syndrome (FPIES) is frequently misdiagnosed and subject to diagnostic delay. Profuse vomiting, the cardinal feature of acute FPIES, may occur in more common pediatric disorders such as gastroenteritis and sepsis.

Objectives: We sought to determine differentiating features at acute presentation between FPIES, gastroenteritis, and sepsis in young children presenting to an emergency department (ED) with profuse vomiting. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.10.020DOI Listing
February 2019
4 Reads

Rapid and specific detection of Salmonella infections using chemically modified nucleic acid probes.

Anal Chim Acta 2019 Apr 21;1054:157-166. Epub 2018 Dec 21.

Department of Physics, Chemistry and Biology, Linkӧping University, Linköping, 58185, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden. Electronic address:

Salmonella is a leading source of bacterial foodborne illness in humans, causing gastroenteritis outbreaks with bacteraemia occurrences that can lead to clinical complications and death. Eggs, poultry and pig products are considered as the main carriers of the pathogenic Salmonella for humans. To prevent this relevant zoonosis, key changes in food safety regulations were undertaken to improve controls in the food production chain. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.027DOI Listing
April 2019
2 Reads
4.513 Impact Factor

Risk factors for upper and lower functional gastrointestinal disorders in Persian Gulf War Veterans during and post-deployment.

Neurogastroenterol Motil 2019 Mar 29;31(3):e13533. Epub 2019 Jan 29.

Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Gastroenteritis is a risk factor for irritable bowel syndrome (IBS), but its role in other functional gastrointestinal disorders (FGIDs) is less clear. The aim of this study was to determine the prevalence of FGIDs in Gulf War (GW) Veterans before, during, and after deployment and to determine whether gastroenteritis was a risk factor for upper and lower FGIDs.

Methods: The Veterans who served during the Persian GW were mailed validated questionnaires inquiring about their bowel habits, psychological and extra-intestinal symptoms, and quality of life (QOL). Read More

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http://doi.wiley.com/10.1111/nmo.13533
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http://dx.doi.org/10.1111/nmo.13533DOI Listing
March 2019
4 Reads

Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children.

Sci Rep 2019 Jan 29;9(1):865. Epub 2019 Jan 29.

Biomedical Research Center, Qatar University, Doha, 2713, Qatar.

Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Read More

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http://dx.doi.org/10.1038/s41598-018-37162-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351549PMC
January 2019
2 Reads
5.078 Impact Factor

Genetics behind the biosynthesis of nonulosonic acid containing lipooligosaccharides in .

J Bacteriol 2019 Jan 28. Epub 2019 Jan 28.

Department of Chemistry and Biology, Ryerson University, Toronto, Canada.

and are the most common cause of bacterial gastroenteritis in the world. Ganglioside mimicry by lipooligosaccharide (LOS) is the triggering factor of Guillain-Barré syndrome (GBS), an acute polyneuropathy. Sialyltransferases from the glycosyltransferase (GT) family 42 are essential for the expression of ganglioside mimics in Recently, two novel GT-42 genes, and , have been identified in Despite being present in ∼11% of currently available genomes, the biological role of and is unknown. Read More

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http://jb.asm.org/lookup/doi/10.1128/JB.00759-18
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http://dx.doi.org/10.1128/JB.00759-18DOI Listing
January 2019
3 Reads

Staphylococcus pseudintermedius septicemia in puppies after elective cesarean section: confirmed transmission via dam's milk.

BMC Vet Res 2019 Jan 28;15(1):41. Epub 2019 Jan 28.

Clinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000, Ljubljana, Slovenia.

Background: In humans, transmission of bacteria causing fatal sepsis in the neonates through mother's milk has been reported. In dogs, it is believed that bacteria from canine milk are not the primary cause of neonatal infections. Staphylococcus pseudintermedius is colonizing the skin and mucocutaneous junctions in adult dogs and can act as an opportunistic pathogen. Read More

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http://dx.doi.org/10.1186/s12917-019-1795-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348621PMC
January 2019
2 Reads

NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production.

World J Gastroenterol 2019 Jan;25(3):330-345

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea.

Background: Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343100PMC
January 2019
1 Read

Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.

BMC Gastroenterol 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Background: The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the region for better management of infections caused by such bacteria.

Methods: Four hundred two gastric biopsy specimens were analyzed using histopathological examination and real time-PCR. Read More

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http://dx.doi.org/10.1186/s12876-019-0934-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346553PMC
January 2019
3 Reads

Missed Diagnosis of New-Onset Systolic Heart Failure at First Presentation in Children with No Known Heart Disease.

J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Houston, TX.

Objective: To determine frequency of missed heart failure diagnosis at first presentation among children with no known heart disease admitted with new-onset heart failure.

Study Design: Using a retrospective design, we reviewed electronic medical records of all patients aged <21 years with no known heart disease, hospitalized with new-onset heart failure during 2003-2015 at a tertiary-quaternary care institution. We assessed records for missed diagnosis of heart failure (primary outcome), associated process breakdowns, and clinical outcomes using a structured data collection instrument. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.029DOI Listing
January 2019
2 Reads
3.790 Impact Factor

Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses.

mSphere 2019 01 23;4(1). Epub 2019 Jan 23.

Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Viral Metagenomics, KU Leuven-University of Leuven, Leuven, Belgium

Diarrhea remains one of the most common causes of deaths in children. A limited number of studies have investigated the prevalence of enteric pathogens in Cameroon, and as in many other African countries, the cause of many diarrheal episodes remains unexplained. A proportion of these unknown cases of diarrhea are likely caused by yet-unidentified viral agents, some of which could be the result of (recent) interspecies transmission from animal reservoirs, like bats. Read More

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http://dx.doi.org/10.1128/mSphere.00585-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344602PMC
January 2019
1 Read

Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580.

PLoS Biol 2019 Jan 15;17(1):e3000059. Epub 2019 Jan 15.

Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.

Salmonella Typhimurium sequence type (ST) 313 causes invasive nontyphoidal Salmonella (iNTS) disease in sub-Saharan Africa, targeting susceptible HIV+, malarial, or malnourished individuals. An in-depth genomic comparison between the ST313 isolate D23580 and the well-characterized ST19 isolate 4/74 that causes gastroenteritis across the globe revealed extensive synteny. To understand how the 856 nucleotide variations generated phenotypic differences, we devised a large-scale experimental approach that involved the global gene expression analysis of strains D23580 and 4/74 grown in 16 infection-relevant growth conditions. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333337PMC
January 2019
2 Reads

Accumulation of virulence-associated proteins in Campylobacter jejuni Outer Membrane Vesicles at human body temperature.

J Proteomics 2019 Mar 11;195:33-40. Epub 2019 Jan 11.

Department of Molecular Biology, Umeå University, Umeå 90187, Sweden; Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå 90187, Sweden. Electronic address:

Campylobacter jejuni is the major cause of bacterial gastroenteritis in humans. In contrast, colonization in avian hosts is asymptomatic. Body temperature differs between human (37 °C) and avian (42 °C) hosts, and bacterial growth in 37 °C is therefore a potential cue for higher virulence properties during human infection. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.01.005DOI Listing
March 2019
2 Reads

Genetic diversity of human parechoviruses in stool samples, Germany.

Infect Genet Evol 2019 Mar 9;68:280-285. Epub 2019 Jan 9.

Institute of Virology, Leipzig University, Leipzig, Germany.

Human parechoviruses (HPeV) are ubiquitous and mainly occur in early infancy. They are known to cause various clinical manifestations including acute gastroenteritis. To gain insight into the diversity of circulating HPeV genotypes, stool samples from patients (n = 539) with clinical signs of infectious gastroenteritis which showed negative results for other common viral and bacterial enteric pathogens were obtained during three years, 2008 to 2010. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.01.007DOI Listing
March 2019
4 Reads

Field evidence for association between increased gastrointestinal nematode burden and subclinical mastitis in dairy sheep.

Vet Parasitol 2019 Jan 7;265:56-62. Epub 2018 Dec 7.

Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece. Electronic address:

The objective of the present study was to study, under field conditions, potential associations between gastrointestinal nematode parasitism and subclinical mastitis in ewes during the lactation period. Faecal and milk samples were collected from 240 ewes in 16 farms, for parasitological and bacteriological plus cytological examination, respectively. In the population sampled, prevalence of gastrointestinal nematode infection was 63. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.010DOI Listing
January 2019
3 Reads

The Role of Maternal Citizenship on Pediatric Avoidable Hospitalization: A Birth Cohort Study in North-East Italy.

Indian J Pediatr 2019 Jan 12;86(Suppl 1):3-9. Epub 2019 Jan 12.

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Objective: Avoidable hospitalization (AH) has been widely studied as a possible measure of primary health care performance. Since studies evaluating AH in migrant children, particularly in Europe, are lacking, the aim of this study was to investigate the role of maternal citizenship on the risk of AH in children.

Methods: The cohort study included all live newborns recorded in the Medical Birth Register (MBR) of Friuli-Venezia Giulia Region (Italy) in the years 1989-2012, followed from 30 d after their birth up to the 14th year of life. Read More

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http://dx.doi.org/10.1007/s12098-018-2826-6DOI Listing
January 2019
1 Read

Survey and genetic characterization of Vibrio cholerae in Apalachicola Bay, Florida (2012-2014).

J Appl Microbiol 2019 Jan 10. Epub 2019 Jan 10.

Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA.

Aims: A small outbreak of gastroenteritis in 2011 in Apalachicola Bay, FL was attributed to consumption of raw oysters carrying Vibrio cholerae serotype O75. To better understand possible health risks, V. cholerae was surveyed in oysters, fish and seawater, and results were compared to data for Vibrio vulnificus and Vibrio parahaemolyticus. Read More

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http://dx.doi.org/10.1111/jam.14199DOI Listing
January 2019

Pathogenomics of Virulence Traits of That Were Deemed Inconclusive by Traditional Experimental Approaches.

Front Microbiol 2018 21;9:3077. Epub 2018 Dec 21.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, South Africa.

One of the major challenges of modern medicine includes the failure of conventional protocols to characterize the pathogenicity of emerging pathogens. This is particularly apparent in the case of . Although a number of infections have been linked to this microorganism, experimental evidence of its virulence factors (VFs), obtained by traditional approaches, is somewhat inconclusive. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309461PMC
December 2018

Antimicrobial Susceptibility and Genomic Structure of Isolates.

Front Microbiol 2018 14;9:3067. Epub 2018 Dec 14.

Institute of Bacterial Infections and Zoonoses (IBIZ), Friedrich Loeffler Institute, Jena, Germany.

spp. are considered the most common bacterial cause of foodborne gastroenteritis in the world. The family includes the genus with the three species , , and as emergent enteropathogens and potential zoonotic agents. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302008PMC
December 2018
1 Read

Prevalence of Mycobacterium avium subspecies paratuberculosis IS 900 DNA in biopsy tissues from patients with Crohn's disease: histopathological and molecular comparison with Johne's disease in Fars province of Iran.

BMC Infect Dis 2019 Jan 7;19(1):23. Epub 2019 Jan 7.

Department of Pathology, School of Veterinary Medicine, Shiraz University, PO Box 71345-1731, Shiraz, Iran.

Background: Crohn's disease is a chronic enteritis of humans that affects the gastrointestinal tract, especially the terminal ileum, cecum and colon. The etiology of this disease is still unknown but seems to be multifactorial. There are reports about the potential link between Crohn's disease in humans and the causative agent of Johne's disease in ruminants. Read More

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http://dx.doi.org/10.1186/s12879-018-3619-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322312PMC
January 2019
3 Reads

Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model.

J Vis Exp 2018 Dec 20(142). Epub 2018 Dec 20.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University;

The human pathogen Aeromonas has been clinically shown to cause gastroenteritis, wound infections, septicemia, and urinary tract infections. Most human diseases have been reported to be associated with four species of bacteria: Aeromonas dhakensis, Aeromonas hydrophila, Aeromonas veronii, and Aeromonas caviae. The model organism Caenorhabditis elegans is a bacterivore that provides an excellent infection model by which to study the bacterial pathogenesis of Aeromonas. Read More

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https://www.jove.com/video/58768/evaluating-virulence-pathog
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http://dx.doi.org/10.3791/58768DOI Listing
December 2018
5 Reads

The epidemiology of non-viral gastroenteritis in New Zealand children from 1997 to 2015: an observational study.

BMC Public Health 2019 Jan 5;19(1):18. Epub 2019 Jan 5.

Department of Paediatrics, University of Otago, PO Box 4345, Christchurch Mail Centre, Christchurch, 8140, New Zealand.

Background: Acute gastroenteritis is a substantial cause of hospitalization in children. Shigella, Salmonella, Campylobacter, Yersinia, enterotoxigenic Escherichia coli (ETEC), Giardia and Cryptosporidium are gastrointestinal pathogens that are notifiable in New Zealand (NZ). The impact of these infections in the pediatric population has not yet been analyzed. Read More

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http://dx.doi.org/10.1186/s12889-018-6229-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321731PMC
January 2019
1 Read

Stump Appendicitis Management.

Am Surg 2018 Dec;84(12):e519-e521

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December 2018
1 Read

Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?

J Biomed Sci 2019 Jan 3;26(1). Epub 2019 Jan 3.

Departments of Biological Sciences, and Pharmacology and Therapeutics, Inflammation Research Network, University of Calgary, 2500 University Dr. N.W, Calgary, T2N 1N4, Canada.

Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these microbiota communities, and how in turn their disruptions may cause disease. Beyond alterations of relative microbial abundance and diversity, the aim of the review is to focus on the disruptions of the microbiota biofilm structure and function, the dispersion of commensal bacteria, and the mechanisms whereby these dispersed commensals may become pathobionts. Read More

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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929
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http://dx.doi.org/10.1186/s12929-018-0495-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317250PMC
January 2019
6 Reads

The Role of Succinate in the Regulation of Intestinal Inflammation.

Nutrients 2018 Dec 22;11(1). Epub 2018 Dec 22.

Division of Gastroenterology, IWK Health Centre, Halifax, NS B3K 6R8, Canada.

Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Read More

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http://www.mdpi.com/2072-6643/11/1/25
Publisher Site
http://dx.doi.org/10.3390/nu11010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356305PMC
December 2018
7 Reads

Modulation of faecal metagenome in Crohn's disease: Role of microRNAs as biomarkers.

World J Gastroenterol 2018 Dec;24(46):5223-5233

Department of Digestive Diseases, Valme University Hospital, UGC Digestive Disease and CIBERehd, Servicio Andaluz de Salud, Seville E-41014, Spain.

Background: The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease (IBD) is abnormal and characterized by reduced diversity. Read More

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http://dx.doi.org/10.3748/wjg.v24.i46.5223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295834PMC
December 2018
1 Read

Action of Colloidal Bismuth Hydroxide Gel and its Commercial Cream on Enteropathogens and Colonizers of the Gastrointestinal Tract.

J Glob Infect Dis 2018 Oct-Dec;10(4):206-211

Department of Microbiology, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Suipacha, Rosario, Santa Fe, Argentina.

Background: Acute diarrheal diseases constitute a world public health problem because they are the second cause of death in children under 5 years of age. Colloidal bismuth hydroxide gel (CBHG) is an active ingredient in low-cost, antidiarrhetic drugs for oral use; it does not inhibit intestinal motility, and it features very low intestinal absorption of <1%.

Materials And Methods: We analyzed the sensitivity by determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC); the effect on bacterial growth by studying the specific growth velocity and the generation time in growth curves; and bacterial attachment by counting viable plaques, of enteropathogenic , shigatoxigenic O157:H7, , spp. Read More

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http://dx.doi.org/10.4103/jgid.jgid_102_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276317PMC
December 2018

Real-time recombinase polymerase amplification assay for the rapid and sensitive detection of Campylobacter jejuni in food samples.

J Microbiol Methods 2019 Feb 18;157:31-36. Epub 2018 Dec 18.

Center of Inspection and Quarantine, Hebei Entry-Exit Inspection and Quarantine Bureau, No. 318 Hepingxilu Road, Shijiazhuang, Hebei Province 050051, People's Republic of China; Hebei Academy of Inspection and Quarantine Science and Technology, No. 318 Hepingxilu Road, Shijiazhuang, Hebei Province 050051, People's Republic of China. Electronic address:

Campylobacter jejuni (C. jejuni), a foodborne pathogen, is a major contributor to human bacterial gastroenteritis worldwide and detrimental to public health. It is crucial for initiating appropriate outbreak control strategies to rapidly detect C. Read More

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http://dx.doi.org/10.1016/j.mimet.2018.12.017DOI Listing
February 2019
1 Read

[Prolonged initial empirical antibiotic treatment and the risk of morbidity and mortality in very low birthweight infants].

Rev Chil Pediatr 2018 Oct;89(5):600-605

Facultad de Medicina, Universidad de Concepción, Chile.

Introduction: The objective of this study is to evaluate the association between the duration of ini tial empirical antibiotic treatment and the subsequent development of late-onset sepsis, necrotizing enterocolitis (NEC) and death in very low birth weight (VLBW) infants.

Patients And Methods: Quantitative, cross-sectional, analytical study of VLBW infants admitted to the neonatal ICU were included over a period of five years. Initial empirical antibiotic therapy was that which started immediately after birth, without knowing the results of blood cultures. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000807DOI Listing
October 2018
1 Read

Clinical and Epidemiologic Profiles for Identifying Norovirus in Acute Gastroenteritis Outbreak Investigations.

Open Forum Infect Dis 2018 Apr 10;5(4):ofy049. Epub 2018 Apr 10.

Rollins School of Public Health, Emory University, Atlanta, Georgia.

Background: Noroviruses are the leading cause of acute gastroenteritis (AGE) outbreaks in the United States. However, outbreaks attributed to norovirus often lack confirmation by diagnostic testing. Clinical and epidemiologic profiles, such as the Kaplan criteria (vomiting in >50% cases, mean incubation period of 24-48 hours, mean duration of illness for 12-60 hours, and negative bacterial stool culture), have been used to distinguish norovirus outbreaks from those caused by bacteria. Read More

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http://dx.doi.org/10.1093/ofid/ofy049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892141PMC
April 2018
2 Reads

Montezuma's revenge - the sequel: The one-hundred year anniversary of the first description of "post-infectious" irritable bowel syndrome.

World J Gastroenterol 2018 Dec;24(45):5076-5080

Department of Enteric Diseases, Naval Medical Research Center, Silver Spring, MD 20910, United States.

One-hundred years have passed since the original description of the commonly described phenomenon of persistent abdominal symptoms being triggered by an acute enteric infection. This first account was generated out of astute observations by Sir Arthur Hurst in World War I. Additional descriptions followed from military and non-military practitioners adding the evidence which has transitioned this recognized condition from association to causation. Read More

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http://dx.doi.org/10.3748/wjg.v24.i45.5076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288650PMC
December 2018

Effect of conjugated linoleic acid overproducing Lactobacillus with berry pomace phenolic extracts on Campylobacter jejuni pathogenesis.

Food Funct 2019 Jan;10(1):296-303

Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA.

Campylobacter jejuni (CJ) is one of the predominant causative agents of acute gastroenteritis in the US and other developed countries through the handling of raw chicken or the consumption of undercooked poultry and poultry products. Probiotics and their metabolites such as conjugated linoleic acids (CLAs) play a crucial role in improving host health and act as antimicrobials against enteric pathogens. Furthermore, prebiotics or prebiotic-like components such as bioactive phenolics from berry pomace can stimulate the growth of beneficial microbes including Lactobacillus casei (LC) and its metabolites, and competitively inhibit the growth of enteric bacterial pathogens. Read More

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http://dx.doi.org/10.1039/c8fo01863dDOI Listing
January 2019
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Optimising the antibiotic treatment of uncomplicated acute appendicitis: a protocol for a multicentre randomised clinical trial (APPAC II trial).

BMC Surg 2018 Dec 17;18(1):117. Epub 2018 Dec 17.

Division of Digestive Surgery and Urology, Turku University Hospital, Kiinanmyllynkatu 4-8, 20520, Turku, Finland.

Background: Based on epidemiological and clinical data acute appendicitis can present either as uncomplicated (70-80%) or complicated (20-30%) disease. Recent studies have shown that antibiotic therapy is both safe and cost-effective for a CT-scan confirmed uncomplicated acute appendicitis. However, based on the study protocols to ensure patient safety, these randomised studies used mainly broad-spectrum intravenous antibiotics requiring additional hospital resources and prolonged hospital stay. Read More

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http://dx.doi.org/10.1186/s12893-018-0451-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296129PMC
December 2018
3 Reads

Rotavirus analyses by SYBR Green real-time PCR and microbiological contamination in bivalves cultivated in coastal water of Amazonian Brazil.

J Water Health 2018 Dec;16(6):970-979

Instituto Evandro Chagas, IEC, BR-316 km 7, Ananindeua, Para, Brazil E-mail:

The contamination of mussels and oysters by viruses and bacteria is often associated with water contamination and gastroenteritis in humans. The present study evaluated viral and bacterial contamination in 380 samples, from nine mollusk-producing regions in coastal water north of the Brazilian Amazon. Rotavirus contamination was studied for groups A to H, using a two-step SYBR Green RT-qPCR (quantitative reverse transcription polymerase chain reaction), and bacterial families Enterobacteriaceae, Vibrionaceae, and Aeromonadaceae by classical and molecular methods. Read More

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http://dx.doi.org/10.2166/wh.2018.130DOI Listing
December 2018
2 Reads

Antibiotic resistance of Campylobacter jejuni isolates recovered from humans with diarrhoea in Turkey.

J Med Microbiol 2019 Feb 12;68(2):136-142. Epub 2018 Dec 12.

3​Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, USA.

Purpose: This study was aimed at investigating the occurrence and genetic mechanisms of resistance to ciprofloxacin, tetracycline and erythromycin in clinical isolates of Campylobacter jejuni recovered from human cases of acute gastroenteritis in Turkey.

Methodology: MIC values of each antibiotic were determined with the epsilometer test (E-test). Resistance genes/mutations were first screened by PCR and analysed by subsequent DNA sequencing. Read More

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http://dx.doi.org/10.1099/jmm.0.000890DOI Listing
February 2019
2 Reads

HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ALLEVIATES HELICOBACTER PYLORI-INDUCED GASTRO-INTESTINAL INFECTION AND GASTRIC INFLAMMATION IN C57BL/6 MICE: AN IMMUNO-HISTOLOGIC STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):279-282

Alborz University of Medical Sciences, Department of Microbiology, Karaj, Iran.

Background: Helicobacter pylori (H. pylori) has been introduced by since 1983 by Marshal and Warren to play the main role in the pathophysiology of gastritis and gastric ulcers. Almost half of the world population1 is infected by H. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-70DOI Listing
January 2019
1 Read

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents.

Pharm Res 2018 Dec 5;36(1):22. Epub 2018 Dec 5.

Department Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123, Saarbrücken, Germany.

Purpose: The objective of this work was to evaluate the potential of polymeric spherical and aspherical invasive nanocarriers, loaded with antibiotic, to access and treat intracellular bacterial infections.

Methods: Aspherical nanocarriers were prepared by stretching of spherical precursors, and both aspherical and spherical nanocarriers were surface-functionalized with the invasive protein InvA497. The relative uptake of nanocarriers into HEp-2 epithelial cells was then assessed. Read More

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http://link.springer.com/10.1007/s11095-018-2521-3
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http://dx.doi.org/10.1007/s11095-018-2521-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290668PMC
December 2018
14 Reads

Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells.

Nat Commun 2018 12 5;9(1):5184. Epub 2018 Dec 5.

Department of Experimental Oncology, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy.

Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate the functional effects of therapeutic FMT administration during experimental colitis on innate and adaptive immune responses in the intestinal mucosa. Read More

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http://www.nature.com/articles/s41467-018-07359-8
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http://dx.doi.org/10.1038/s41467-018-07359-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281577PMC
December 2018
14 Reads

Performance of Stool Testing Recommendations for Acute Gastroenteritis when Used to Identify Children with Nine Potential Bacterial Enteropathogens.

Clin Infect Dis 2018 Dec 4. Epub 2018 Dec 4.

Sections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The ability to identify bacterial pathogens that necessitate specific clinical management or public health action in children with acute gastroenteritis is crucial to patient care and public health. However, existing stool testing guidelines offer inconsistent recommendations, and their performance characteristics are unknown. We evaluated six leading gastroenteritis guidelines (e. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy1021DOI Listing
December 2018
22 Reads

Diarrheagenic Associated with Acute Gastroenteritis in Children from Soriano, Uruguay.

Can J Infect Dis Med Microbiol 2018 24;2018:8387218. Epub 2018 Oct 24.

Bacteriology and Virology Department, Hygiene Institute, Medicine Faculty, Universidad de la República, Uruguay.

Introduction: Acute diarrheal disease still deserves worldwide attention due to its high morbidity and mortality, especially in developing countries. While etiologic determination is not mandatory for management of all individual cases, it is needed for generating useful epidemiologic knowledge. Diarrheagenic (DEC) are relevant enteropathogens, and their investigation requires specific procedures to which resources and training should be dedicated in reference laboratories. Read More

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https://www.hindawi.com/journals/cjidmm/2018/8387218/
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http://dx.doi.org/10.1155/2018/8387218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234443PMC
October 2018
10 Reads

A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.

Nutrients 2018 Dec 2;10(12). Epub 2018 Dec 2.

National Institute of Gastroenterology "S. de Bellis", Institute of Research, 70013 Castellana Grotte (BA), Italy.

Inflammatory bowel diseases (IBD) are debilitating chronic inflammatory disorders that develop as a result of a defective immune response toward intestinal bacteria. Intestinal dysbiosis is associated with the onset of IBD and has been reported to persist even in patients in deep remission. We investigated the possibility of a dietary-induced switch to the gut microbiota composition using Winnie mice as a model of spontaneous ulcerative colitis and chow enriched with 1% Bronze tomato. Read More

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http://dx.doi.org/10.3390/nu10121862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315348PMC
December 2018
2 Reads

Estimating the incidence of norovirus acute gastroenteritis among US and European international travelers to areas of moderate to high risk of traveler's diarrhea: a prospective cohort study protocol.

BMC Infect Dis 2018 Dec 3;18(1):605. Epub 2018 Dec 3.

University of Texas McGovern Medical School and School of Public Health, 1200 Pressler Street, Houston, TX, 77030, USA.

Background: Acute gastroenteritis (AGE) is the leading cause of illness among returning travelers seeking medical care. Multiple types of enteric pathogens can cause travel-acquired AGE and, while bacterial pathogens have a predominant role, the importance of viruses, such as norovirus, is increasingly recognized. There is a lack of information on travel-acquired norovirus incidence among symptomatic and asymptomatic individuals irrespective of healthcare-seeking behavior. Read More

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http://dx.doi.org/10.1186/s12879-018-3461-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276235PMC
December 2018
2 Reads

Prevalence of Clostridium perfringens netE and netF toxin genes in the feces of dogs with acute hemorrhagic diarrhea syndrome.

J Vet Intern Med 2019 Jan 30;33(1):100-105. Epub 2018 Nov 30.

Department of Clinical Veterinary Medicine, Clinic of Small Animal Internal Medicine, Ludwig Maximilian University of Munich, Munich, Germany.

Background: Recently, novel pore-forming toxin genes designated netE and netF were identified in a Clostridium perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea.

Objectives: Pore-forming toxins could play an important role in the disease pattern of acute hemorrhagic diarrhea syndrome (AHDS) in dogs. Thus, we aimed to determine the prevalence of C. Read More

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http://dx.doi.org/10.1111/jvim.15361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335515PMC
January 2019
2 Reads

Etiologic and clinical characterization of community acquired gastroenteritis in adult patients in a Chilean emergency room by the FilmArray GI panel.

PLoS One 2018 26;13(11):e0207850. Epub 2018 Nov 26.

Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Infectious diarrhea can be caused by a large number of microorganisms including bacteria virus and parasites. The clinical syndromic approach has been traditionally used to guide therapy. The aim of this study was to characterize the etiology of acute diarrhea by the FilmArray GI panel and to correlate it with its clinical presentation in an adult population presenting to the emergency room in a developing country. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207850PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258233PMC
November 2018
8 Reads

Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells.

Sci Rep 2018 Nov 19;8(1):16996. Epub 2018 Nov 19.

Department of Molecular Biology, Umeå University, 90187, Umea, Sweden.

Campylobacter jejuni is a prevalent human pathogen and a major cause of bacterial gastroenteritis in the world. In humans, C. jejuni colonizes the intestinal tract and its tolerance to bile is crucial for bacteria to survive and establish infection. Read More

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http://www.nature.com/articles/s41598-018-35409-0
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http://dx.doi.org/10.1038/s41598-018-35409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242867PMC
November 2018
13 Reads

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

Nat Commun 2018 11 19;9(1):4846. Epub 2018 Nov 19.

Department of Internal Medicine, Ghent University, Ghent, B-9052, Belgium.

Clostridium difficile is the leading cause of pseudomembranous colitis in hospitalized patients. C. difficile enterotoxins TcdA and TcdB promote this inflammatory condition via a cytotoxic response on intestinal epithelial cells (IECs), but the underlying mechanisms are incompletely understood. Read More

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http://www.nature.com/articles/s41467-018-07386-5
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http://dx.doi.org/10.1038/s41467-018-07386-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242954PMC
November 2018
12 Reads

The burden of gastroenteritis in Switzerland (BUGS) study: a research proposal for a 1-year, prospective cohort study.

BMC Res Notes 2018 Nov 16;11(1):816. Epub 2018 Nov 16.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Objectives: Acute gastroenteritis (AG) is a usually self-limiting, but common disease worldwide. In Europe, incidence estimates range from 0.3-1. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3916-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240284PMC
November 2018
8 Reads