26,805 results match your criteria Gastroenteritis Bacterial

Severe Gastroenteritis From Giardia lamblia and Salmonella Saintpaul Co-Infection Causing Acute Renal Failure.

Cureus 2022 May 24;14(5):e25288. Epub 2022 May 24.

Clinical Research, Michigan State University School of Osteopathic Medicine, Detroit, USA.

Giardiasis, a feco-oral route parasitic intestinal infection, and Salmonellosis, a foodborne enteric and extraintestinal bacterial infection, remain major public health issues in countries that lack adequate sanitation, safe water supply, and proper food handling. Here we report a case of and invasive non-typhoidal Salmonella disease co-infection in a patient with a history of recent travel to Mexico. Read More

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The anti-campylobacter activity of eugenol and its potential for poultry meat safety: A review.

Food Chem 2022 Jun 18;394:133519. Epub 2022 Jun 18.

Marmara University, Department of Nutrition and Dietetics, Istanbul, Turkey. Electronic address:

Poultry is one of the fastest growing industries due to advantages in land use, rapid production and advances in feed technology. The rising trend in the consumption of poultry meat over the last 50 years has also increased concerns about food safety. Campylobacter jejuniis the leading bacterial cause of gastroenteritis, the foremost cause of foodborne deaths. Read More

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Advancing Precision Vaccinology by Molecular and Genomic Surveillance of SARS-CoV-2 in Germany, 2021.

Clin Infect Dis 2022 Jun 25. Epub 2022 Jun 25.

Systems Medicine of Infectious Disease (P5), Robert Koch-Institute, Berlin, Germany.

Background: Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track the spread of this and other SARS-CoV-2 variants of concern led to an expansion of genomic sequencing activities in Germany.

Methods: At Robert Koch Institute (RKI), the German National Institute of Public Health, we established the "Integrated Molecular Surveillance for SARS-CoV-2" (IMS-SC2) network to perform SARS-CoV-2 genomic surveillance at the national scale, SARS-CoV-2 positive samples from laboratories distributed across Germany regularly undergo whole-genome sequencing at RKI. Read More

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Retroperitoneal and iliopsoas abscess as Crohn's disease onset mimicking a common lumbosciatic pain.

Ann Ital Chir 2022 Jun 15;11. Epub 2022 Jun 15.

Crohn's Disease (CD) refers to a chronic transmural bowel inflammation affecting a range between 5 and 15 per 100,000 person-years worldwide 1. In patients with stricturing CD, the transmural pattern of inflammation may trigger the development of sinus tracts able to connect to other tissues, leading to the formation of fistulas or abscesses 2. Intra-psoas abscesses are rare, affecting between 0. Read More

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[Neutropenic enterocolitis in the pediatric cancer patient].

Rev Chilena Infectol 2022 02;39(1):59-69

Hospital Clínico San Borja Arriarán, Chile.

Neutropenic enterocolitis (NEC) is a heterogeneous disease of the gastrointestinal tract with systemic response, that corresponds to a severe and life-threatening clinical condition in immunocompromised patients, especially in childhood cancer. The pathologic features are poorly understood, although its multifactorial cause of NEC is well established and it is associated with the cytotoxic effects of the chemotherapy agents used and recognized by the classic triad of fever, neutropenia, and abdominal pain, secondary to gastrointestinal injuries that alters mucosal permeability and helps intramural bacterial invasion. NEC is truly a clinical challenge that requires an early diagnosis and a multidisciplinary approach including basic laboratory and imagological tests in high complexity centers. Read More

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February 2022

Antibiotics for uncomplicated diverticulitis.

Cochrane Database Syst Rev 2022 06 22;6:CD009092. Epub 2022 Jun 22.

Department of Surgical Gastroenterology , Hvidovre University Hosipital , Copenhagen, Denmark.

Background: Diverticulitis is a complication of the common condition, diverticulosis. Uncomplicated diverticulitis has traditionally been treated with antibiotics, as diverticulitis has been regarded as an infectious disease. Risk factors for diverticulitis, however, may suggest that the condition is inflammatory rather than infectious which makes the use of antibiotics questionable. Read More

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Cortisol Levels During Acute Illnesses in Children and Adolescents: A Systematic Review.

JAMA Netw Open 2022 Jun 1;5(6):e2217812. Epub 2022 Jun 1.

Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, United Kingdom.

Importance: Endogenous cortisol levels in children and adolescents during acute illnesses can contribute to the evidence base required to optimize glucocorticoid (GC) stress doses for children and adolescents known to have GC deficiency.

Objective: To identify endogenous cortisol levels during a range of acute illnesses in children and adolescents without GC deficiency from published evidence.

Evidence Review: CINAHL, Cochrane Library, Cochrane Database of Systematic Reviews, Embase, and MEDLINE were searched for studies published between January 1, 2000, and June 30, 2020. Read More

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Identification of Helicobacter pylori-related gastric cancer risk using serological gastritis markers and endoscopic findings: a large-scale retrospective cohort study.

BMC Gastroenterol 2022 Jun 20;22(1):299. Epub 2022 Jun 20.

Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.

Background: Gastric cancer remains a severe public health problem worldwide, particularly in Japan. Recent studies have demonstrated that serum markers are beneficial for risk stratification in gastric cancer development. We aimed to evaluate the usefulness of serum markers either alone or in combination (serum markers plus endoscopy) for effective risk stratification of gastric cancer development. Read More

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Gastroenteritis Among Under-Five Children in Southwest Ethiopia.

Infect Drug Resist 2022 9;15:2969-2979. Epub 2022 Jun 9.

School of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Under-five children are at an increased risk for foodborne illnesses because of the ingenuousness of their immune system. Although species are one of the bacterial etiologies of gastroenteritis, gastroenteritis among under-five children is not well considered in Ethiopia. Therefore, this study aimed at exploring the prevalence, associated risk factors, and antibiotic susceptibility patterns of species among under-five children with diarrhea. Read More

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Antibiotic treatment for appendicitis in Norway and Sweden: a nationwide survey on treatment practices.

BMC Surg 2022 Jun 15;22(1):229. Epub 2022 Jun 15.

Department of Gastrointestinal and HPB Surgery, University Hospital of Northern Norway, Tromsø, Norway.

Background: Appendicitis is one of the most common causes of acute abdomen. Uncomplicated appendicitis is as an inflamed appendix without perforation, gangrene or abscess formation. Recent trials show that one can safely treat uncomplicated appendicitis with antibiotics, given patient approval and appropriate follow-up. Read More

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Saireito, a Japanese herbal medicine, alleviates leaky gut associated with antibiotic-induced dysbiosis in mice.

PLoS One 2022 15;17(6):e0269698. Epub 2022 Jun 15.

Department of Infectious Disease Control, Faculty of Medicine, Oita University, Yufu, Oita, Japan.

Antibiotics disrupt normal gut microbiota and cause dysbiosis, leading to a reduction in intestinal epithelial barrier function. Disruption of the intestinal epithelial barrier, which is known as "leaky gut", results in increased intestinal permeability and contributes to the development or exacerbation of gastrointestinal diseases such as inflammatory bowel disease and irritable bowel syndrome. We have previously reported on a murine model of intestinal epithelial barrier dysfunction associated with dysbiosis induced by the administration of ampicillin and vancomycin. Read More

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Sequence addition to the N- or C-terminus of the major capsid protein VP1 of norovirus affects its cleavage and assembly into virus-like particles.

Microb Pathog 2022 Jun 11;169:105633. Epub 2022 Jun 11.

The Sixth People's Hospital of Zhengzhou, Zhengzhou, 450000, China. Electronic address:

Norovirus (NoV) infection is a leading cause of non-bacterial gastroenteritis worldwide and there are currently no effective therapeutics available to target the virus. The norovirus major capsid protein VP1 is a potential candidate for the development of vaccines due to the similar morphology and immunogenicity of its assembled virus-like particles (VLPs) compared to native virions. In this study, we explored the effects of N- and C-terminal sequence additions to the VP1 of a GII. Read More

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Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice.

Microbiome 2022 Jun 14;10(1):91. Epub 2022 Jun 14.

Universite Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Domaine de Vilvert, 78352, Jouy en Josas, France.

Background: Innate immunity genes have been reported to affect susceptibility to inflammatory bowel diseases (IBDs) and colitis in mice. Dectin-1, a receptor for fungal cell wall β-glucans, has been clearly implicated in gut microbiota modulation and modification of the susceptibility to gut inflammation. Here, we explored the role of Dectin-1 and Dectin-2 (another receptor for fungal cell wall molecules) deficiency in intestinal inflammation. Read More

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Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients.

Gut Microbes 2022 Jan-Dec;14(1):2083419

Center for Translational and Clinical Research, University of Zagreb School of Medicine, Zagreb, Croatia.

The knowledge on how gut microbes contribute to the inflammatory bowel disease (IBD) at the onset of disease is still scarce. We compared gut microbiota in newly diagnosed, treatment-naïve adult IBD (Crohn's disease (CD) and ulcerative colitis (UC)) to irritable bowel syndrome (IBS) patients and healthy group. Mucosal and fecal microbiota of 49 patients (13 UC, 10 CD, and 26 IBS) before treatment initiation, and fecal microbiota of 12 healthy subjects was characterized by 16S rRNA gene sequencing. Read More

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Multilocus Sequence Typing and Virulence Potential of Strains Isolated from Aquatic Bird Feces.

Microbiol Spectr 2022 Jun 13:e0088622. Epub 2022 Jun 13.

Department of Microbiology, Faculty of Public Health, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Vibrio parahaemolyticus is a Gram-negative, foodborne pathogenic bacterium that causes human gastroenteritis. This organism is ubiquitously present in the marine environment. Detection of V. Read More

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Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.

Front Immunol 2022 25;13:842911. Epub 2022 May 25.

Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Introduction: Inflammatory bowel disease (IBD) is characterized by a disturbed gut microbiota composition. Patients with IBD have both elevated mucosal and serum levels of IgG-antibodies directed against bacterial antigens, including flagellins. In this study, we aimed to determine to which intestinal bacteria the humoral immune response is directed to in patients with IBD. Read More

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Development of an ultra-sensitive single-tube nested PCR assay for rapid detection of Campylobacter jejuni in ground chicken.

Food Microbiol 2022 Sep 27;106:104052. Epub 2022 Apr 27.

Department of Human, Nutrition, Food and Animal Science, University of Hawaii at Manoa, 1955 East West Road, Agricultural Sciences Building 216, Honolulu, HI, 96822, USA. Electronic address:

Traditional culture-based detection methods for Campylobacteri jejuni, a leading cause of human bacterial gastroenteritis worldwide, are time-consuming, cumbersome, and lacking in reliability. While polymerase chain reaction (PCR) has been frequently used for pathogen testing, it might generate false-negative results due to inadequate sensitivity. This study was the first to explore novel single-tube nested PCR (STN-PCR) to detect pathogens in food. Read More

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September 2022

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells.

Infect Immun 2022 Jun 9:e0066321. Epub 2022 Jun 9.

Department of Microbiology, University of Pennsylvaniagrid.25879.31 Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that causes diseases ranging from gastroenteritis to systemic infection and sepsis. Salmonella uses type III secretion systems (T3SS) to inject effectors into host cells. While these effectors are necessary for bacterial invasion and intracellular survival, intracellular delivery of T3SS products also enables detection of translocated Salmonella ligands by cytosolic immune sensors. Read More

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Rhabdomyolysis and Acute Kidney Injury Associated with Salmonella Infection: A Report of 2 Cases.

Am J Case Rep 2022 Jun 8;23:e936407. Epub 2022 Jun 8.

Department of Internal Medicine, HANSUNG Union Internal Medicine Clinic and Dialysis Center, Daegu, South Korea.

BACKGROUND Rhabdomyolysis is a clinical syndrome characterized by elevated serum creatine kinase (CK) and myoglobin levels due to the breakdown of muscle fibers and is associated with symptoms such as myalgia, muscle swelling, and erythruria. Rhabdomyolysis has an array of potential causes, including Salmonella infection, although rare. We report 2 cases in which nontyphoidal salmonellae caused acute gastroenteritis complicated by rhabdomyolysis and myoglobinuric acute kidney injury (AKI). Read More

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Novel drug delivery systems for inflammatory bowel disease.

World J Gastroenterol 2022 May;28(18):1922-1933

Department of Medicine, Texas A&M University, College Station, TX 77843, United States.

Inflammatory bowel disease (IBD) is a chronic illness characterized by relapsing inflammation of the intestines. The disorder is stratified according to the severity and is marked by its two main phenotypical representations: Ulcerative colitis and Crohn's disease. Pathogenesis of the disease is ambiguous and is expected to have interactivity between genetic disposition, environmental factors such as bacterial agents, and dysregulated immune response. Read More

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Prevalence and antimicrobial susceptibility pattern of Campylobacter jejuni in raw retail chicken meat in Metropolitan Accra, Ghana.

Int J Food Microbiol 2022 Sep 28;376:109760. Epub 2022 May 28.

Veterinary Public Health Research Laboratory, Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, P.O. Box 1555, United Arab Emirates. Electronic address:

Although, Campylobacter spp. are a major cause of foodborne gastroenteritis, its occurrence and antimicrobial resistance traits have not been well defined in low income countries, particularly in Africa. In this study, retail chicken was sampled (n = 400) between February 2019 to January 2020 in Metropolitan Accra, Ghana, to determine the prevalence and antimicrobial susceptibility pattern of Campylobacter jejuni. Read More

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September 2022

Shigella iron-binding proteins: An insight into molecular physiology, pathogenesis, and potential target vaccine development.

Vaccine 2022 Jun 31;40(30):3991-3998. Epub 2022 May 31.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia. Electronic address:

Shigella is a well-known etiological agent responsible for intestinal infection among children, the elderly, and immunocompromised people ranging from mild to severe cases. Shigellosis remains endemic in Malaysia and yet there is no commercial vaccine available to eradicate the disease. Iron is an essential element for the survival of Shigella within the host. Read More

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Acute appendicitis during the recovery phase of dengue hemorrhagic fever: two case reports.

J Med Case Rep 2022 Jun 5;16(1):219. Epub 2022 Jun 5.

Registrar in Paediatrics, Teaching Hospital, Batticaloa, Sri Lanka.

Background: Dengue fever is one of the most common tropical diseases, with high prevalence in many tropical countries including Sri Lanka. Dengue infection can present from subclinical infection to dengue shock syndrome. Further, the disease also shows a variety of atypical presentations and has been reported to mimic a number of causes of acute abdomen. Read More

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α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function.

Mol Med 2022 06 3;28(1):59. Epub 2022 Jun 3.

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, People's Republic of China.

Background And Aims: Cholinergic output, which could modulate innate immune responses through stimulation of α7 nicotinic acetylcholine receptor (α7nAChR), might be a target to minimize tissue damage in autoimmune disease. GTS-21, a selective α7nAChR agonist, has previously demonstrated to inhibit synovium inflammation in rheumatoid arthritis. In this study, we investigated the effect of GTS-21 on dextran sulfate sodium (DSS)-induced colitis model and its potential mechanism. Read More

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A young child with acute perforated appendicitis due to : a rare case report.

Pan Afr Med J 2022 8;41:186. Epub 2022 Mar 8.

Faculty of Medicine and Pharmacy of Marrakech Cadi Ayyad University, Microbiology Department, Mohamed VI University Hospital, Marrakech, Morocco.

Comamonas species are rarely associated with human infections. Recent reports found that Comamonas kerstersii was associated with severe diseases such as abdominal infection and bacteremia. However, Comamonas kerstersii may be confused with Comamonas testosteroni using the automatic bacterial identification systems currently available. Read More

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Inappropriate use of antibiotics and its predictors in pediatric patients admitted at the Central Hospital of Nampula, Mozambique.

Antimicrob Resist Infect Control 2022 Jun 2;11(1):79. Epub 2022 Jun 2.

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, S/nº Campus Universitário Canela, Salvador, BA, 40110-040, Brazil.

Background: Antibiotics are synthetic or natural substances used to treat bacterial infectious diseases. When used incorrectly, they can be a factor in the development of antimicrobial resistance, increased treatment time, costs, and mortality. The present study aimed to assess the pattern of inappropriate use of antibiotics and their predictors in pediatric patients admitted to the Central Hospital in Nampula, Mozambique. Read More

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Outcomes of Restricted versus Liberal Post-Operative Antibiotic Use in Patients Undergoing Appendectomy: A DOOR/RADAR Post Hoc Analysis of the EAST Appendicitis MUSTANG Study.

Surg Infect (Larchmt) 2022 Jun;23(5):489-494

Division of Trauma and Surgical Critical Care, Department of Surgery, University of Miami, Jackson Memorial Hospital Ryder Trauma Center, Miami, Florida, USA.

There is no consensus on the duration of antibiotic use after appendectomy. We hypothesized that restricted antibiotic use is associated with better clinical outcomes. We performed a post hoc analysis of the Eastern Association for the Surgery of Trauma (EAST) Multicenter Study of the Treatment of Appendicitis in America-Acute, Perforated, and Gangrenous (MUSTANG) study using the desirability of outcome ranking/response adjusted for duration of antibiotic risk (DOOR/RADAR) framework. Read More

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[Features of intestinal flora in children with food protein-induced proctocolitis based on high-throughput sequencing].

Zhongguo Dang Dai Er Ke Za Zhi 2022 May;24(5):536-542

Graduate School of Zunyi Medical University, Zunyi, Guizhou 563000, China.

Objectives: To study the features of intestinal flora in children with food protein-induced proctocolitis (FPIP) by high-throughput sequencing.

Methods: A total of 31 children, aged <6 months, who experienced FPIP after exclusive breastfeeding and attended the outpatient service of the Third Affiliated Hospital of Zunyi Medical University from October 2018 to February 2021 were enrolled as the FPIP group. Thirty-one healthy infants were enrolled as the control group. Read More

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Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended-spectrum β-lactamase-producing enteroaggregative Escherichia coli infection.

Microbiome 2022 05 28;10(1):79. Epub 2022 May 28.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.

Background: Antimicrobials are often used to prevent and treat diarrhea induced by enteroaggregative Escherichia coli (EAEC) in young ruminants. However, drug overuse or misuse accelerates the spread of multidrug-resistant extended-spectrum β-lactamase (ESBL)-producing E. coli. Read More

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Validation of RapidChek® Campylobacter Test System for the Detection of C. jejuni, C. coli, and C. lari in Poultry Samples AOAC performance tested MethodSM 052201.

J AOAC Int 2022 May 31. Epub 2022 May 31.

Romer Labs, Inc, 130 Sandy Drive, Newark, Delaware, 19713.

Background: Campylobacter is one of the leading causes of human bacterial gastroenteritis worldwide. Campylobacter infections are most often associated with the consumption of raw milk, undercooked poultry, and contaminated water.

Objective: The RapidChek® Campylobacter test system (PTM Number 052201) was validated for the detection of Campylobacter jejuni, Campylobacter coli, and Campylobacter lari in raw ground chicken, chicken carcass rinse, and turkey carcass sponges. Read More

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