237,331 results match your criteria Gastroenteritis


Norovirus passive surveillance as an alternative strategy for genetic diversity assessment in developing countries.

J Infect Public Health 2021 Jun 2;14(8):990-993. Epub 2021 Jun 2.

Laboratory of Viral Gastroenteritis, INEI-ANLIS "Dr. Carlos G. Malbrán", Av. Vélez Sársfield 563, Buenos Aires 1281, Argentina.

In developing countries, the acute gastroenteritis outbreaks submitted for viral testing are limited due to deficient surveillance programs. The aim of this study was to analyze a passive surveillance strategy for monitoring the molecular epidemiology of norovirus (NV) and counterbalance the genetic diversity data gap. Laboratory-confirmed rotavirus negative sporadic stool samples (N = 523) collected between 2010 and 2017 from children were selected from our archival collection and were tested for NV and sequencing was performed on the positive samples. Read More

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Enterohepatic species - clinical importance, host range, and zoonotic potential.

Crit Rev Microbiol 2021 Jun 21:1-34. Epub 2021 Jun 21.

Faculty of Sciences, Institute of Biochemistry and Microbiology, Universidad Austral de Chile, Valdivia, Chile.

The genus defined just over 30 years ago, is a highly diverse and fast-growing group of bacteria that are able to persistently colonize a wide range of animals. The members of this genus are subdivided into two groups with different ecological niches, associated pathologies, and phylogenetic relationships: the gastric (GH) and the enterohepatic (EHH) species. Although GH have been mostly studied, EHH species have become increasingly important as emerging human pathogens and potential zoonotic agents in the last years. Read More

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Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: 2019/2020 Season in Guangzhou, China.

Food Environ Virol 2021 Jun 21. Epub 2021 Jun 21.

Medical Genetic Centre, Guangdong Women and Children's Hospital, Guangzhou Medical University, Guangzhou, 511442, People's Republic of China.

Norovirus, the leading cause of non-bacterial acute gastroenteritis (AGE) worldwide, is constantly mutating. Continuous monitoring of the evolution of epidemic genotypes and emergence of novel genotypes is, therefore, necessary. This study determined the prevalence and clinical characteristics of norovirus strains in AGE in Guangzhou, China in 2019/2020 season. Read More

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Eosinophilic gastroenteritis in a melanoma patient treated with nivolumab.

J Dermatol 2021 Jun 20. Epub 2021 Jun 20.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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growth-inhibitory effects of L. formulation on intestinal pathogens.

Access Microbiol 2021 Mar 24;3(3):000208. Epub 2021 Feb 24.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Introduction: Empirical evidence suggests that L. treats enteric infections, including dysentery, cholera, and acute infectious gastroenteritis.

Aim: The aim of this study is to clarify the growth-inhibitory effects of L. Read More

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Bacterial gastroenteritis caused by the putative zoonotic pathogen : First reported case in Germany.

Access Microbiol 2021 Mar 25;3(3):000199. Epub 2021 Jan 25.

Thuringian State Authority for Consumer Protection, Tennstedter Str. 8/9, 99947 Bad Langensalza, Thuringia, Germany.

Foodborne campylobacteriosis is the most common cause of human bacterial enteritis in Germany. and are the main causative agents for enteric disease, but a number of other species are involved, including rare ones. These rare spp. Read More

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The effect of meteorological variables on salmonellosis incidence in Kermanshah, West of Iran: a generalized linear model with negative binomial approach.

J Environ Health Sci Eng 2021 Jun 27;19(1):1171-1177. Epub 2021 May 27.

Research Deputy of Iranian Meteorological Organization (IRIMO), Tehran, Iran.

Purpose: Salmonella is one of the main causes of gastroenteritis, and its incidence may be affected by meteorological variables. This is the first study about the effect of climatic factors on salmonella incidence in Kermanshah, Iran.

Methods: Data about salmonellosis cases in Kermanshah were inquired from Center for Communicable Disease Control, at the Ministry of Health and Medical Education of Iran, for the 2008 to 2018 time-frame. Read More

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Reverse genetic engineering of simian rotaviruses with temperature-sensitive lesions in VP1, VP2, and VP6.

Virus Res 2021 Jun 16:198488. Epub 2021 Jun 16.

Department of Biology, Wake Forest University, Winston-Salem, NC. Electronic address:

Rotaviruses are 11-segmented double-stranded RNA viruses and important causes of acute gastroenteritis in young children. To investigate the functions of specific viral proteins during the rotavirus lifecycle, temperature-sensitive (ts) mutants were previously created using a cultivatable simian strain (SA11) and chemical mutagenesis. These ts SA11 mutants replicate more efficiently at the permissive temperature of 31°C than at the non-permissive temperature of 39°C. Read More

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The Statewide Economic Impact of Child Care-Associated Viral Acute Gastroenteritis Infections.

J Pediatric Infect Dis Soc 2021 Jun 19. Epub 2021 Jun 19.

Departments of Emergency Medicine and Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Introduction: More than 65% of children aged ≤5 years in the United States require out-of-home child care. Child care attendance has been associated with an elevated risk of respiratory illness and acute gastroenteritis (AGE). While child care-associated respiratory disease cases are more numerous, AGE is associated with more severe symptoms and more than double the number of absences from child care. Read More

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Benefit- risk assessment of off-label drug use in children: the bravo framework.

Clin Pharmacol Ther 2021 Jun 18. Epub 2021 Jun 18.

Departments of Pharmacology and Toxicology, and Intensive Care, Radboud Institute Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

A drug is granted a license for use after a thorough assessment of risks and benefits based on high quality scientific proof of its efficacy and safety. Many drugs that are relevant to children are not licensed for use in this population implying that a thorough assessment of risks and benefits in the pediatric population has not been made at all, implying a negative risk-benefit balance in children or implying insufficient information to establish the risk-benefit balance. Use of drugs without positive assessment of risks and benefits exposes children to potential lack of efficacy, unknown toxicity and harm. Read More

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Single cell analyses reveal distinct adaptation of typhoidal and non-typhoidal Salmonella enterica serovars to intracellular lifestyle.

PLoS Pathog 2021 Jun 18;17(6):e1009319. Epub 2021 Jun 18.

Abt. Mikrobiologie, Universität Osnabrück, Osnabrück, Germany.

Salmonella enterica is a common foodborne, facultative intracellular enteropathogen. Human-restricted typhoidal S. enterica serovars Typhi (STY) or Paratyphi A (SPA) cause severe typhoid or paratyphoid fever, while many S. Read More

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Novel presentation of the c.1856A > G (p.Asp619Gly) TSHR gene-activating variant: relapsing hyperthyroidism in three subsequent generations manifesting in early childhood and an in vitro functional study.

Hormones (Athens) 2021 Jun 18. Epub 2021 Jun 18.

Vera Vavrova Laboratory/VIAL, Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.

Background: Familial non-autoimmune hyperthyroidism is a rare disease caused by germline activating variants in the thyroid-stimulating hormone receptor (TSHR) gene. The c.1856A > G (p. Read More

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Incidence of Infections and Predictors of Mortality During Checkpoint Inhibitor Immunotherapy in Patients With Advanced Lung Cancer: A Retrospective Cohort Study.

Open Forum Infect Dis 2021 Jun 13;8(6):ofab187. Epub 2021 Apr 13.

Thoracic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

Background: Immune checkpoint inhibitors (ICIs) have revolutionized nonsmall cell lung cancer (NSCLC) treatment and significantly increased overall survival of patients. However, the incidence of concurrent infections and their management is still debated.

Methods: From August 2015 to October 2019, all consecutive patients with NSCLC who received nivolumab or pembrolizumab as first- or second-line therapy were retrospectively evaluated. Read More

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Eosinophilic gastroenteritis with abdominal pain and ascites: A case report.

World J Clin Cases 2021 Jun;9(17):4238-4243

Department of Gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

Background: Eosinophilic gastroenteritis (EGE) is a rare disease that presents many unspecific gastroenterological symptoms. The disease includes three types depending on the depth of eosinophil infiltration in the gastrointestinal tract. The serosal type is the most rare, presenting as ascites. Read More

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Melatonin and other indoles show antiviral activities against swine Coronaviruses in vitro at pharmacological concentrations.

J Pineal Res 2021 Jun 17:e12754. Epub 2021 Jun 17.

Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Weigang 1, Nanjing, 210095, China.

The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights major gaps in our knowledge on the prevention control and cross-species transmission mechanisms of animal coronaviruses. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine delta-coronavirus (PDCoV) are three common swine coronaviruses and have similar clinical features. In absence of effective treatments, they have led to significant economic losses in the swine industry worldwide. Read More

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Phylogenetic analysis of VP7 and VP4 genes of the most predominant human group A rotavirus G12 identified in children with acute gastroenteritis in Himachal Pradesh, India during 2013-2016.

J Med Virol 2021 Jun 17. Epub 2021 Jun 17.

Department of Biotechnology, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi, 110062, India.

G12 strains are now considered to be the sixth most prevalent human rotaviruses globally. India has introduced rotavirus vaccine Rotavac into the national immunization program in 2016 and Himachal Pradesh (HP) is the first state to launch it. During epidemiological rotavirus surveillance in HP, predominance of G12 rotaviruses was observed. Read More

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Genetic characterization and phylogenetic variations of human adenovirus-F strains circulating in eastern India during 2017-2020.

J Med Virol 2021 Jun 17. Epub 2021 Jun 17.

Division of Virology, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road Scheme- XM, Beliaghata, Kolkata, 700010, India.

Human Adenovirus-F (genotype 40/41) is the second-most leading cause of paediatric gastroenteritis after rotavirus, worldwide, accounting for 2.8-11.8% of infantile diarrhoeal cases. Read More

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Menetrier's disease. A diagnostic and therapeutic challenge.

Medicina (B Aires) 2021 ;81(3):470-473

División Gastroenterología, Hospital de Clínicas José de San Martin, Buenos Aires, Argentina.

We present a rare case of hypertrophic gastropathy associated with protein loss. A 35-year-old man was hospitalized for bowel habit changes, abdominal pain, generalized edema and symptomatic anemia. Pertinent laboratory findings included iron deficiency anemia (Hb 6. Read More

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Rare Cause of Left Upper Abdominal Pain.

Prague Med Rep 2021 ;122(2):106-111

Grantham and District Hospital, Grantham, United Kingdom.

Inflamed diverticular disease of the small bowel is an uncommon cause of acute abdominal pain. Despite its low prevalence rate (0.3-2%), it is associated with a high mortality rate between 20-25% (Fisher and Fortin, 1977; Ferreira-Aparicio et al. Read More

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Fecal microbiota transplantation ameliorates experimental colitis gut microbiota and T-cell modulation.

World J Gastroenterol 2021 Jun;27(21):2834-2849

Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.

Background: Emerging evidence has demonstrated that fecal microbiota transplantation (FMT) has a promising therapeutic effect on mice with experimental colitis and patients with ulcerative colitis (UC), although the mechanism of FMT is unclear.

Aim: To evaluate the protective effect of FMT on UC and clarify its potential dependence on the gut microbiota, through association analysis of gut microbiota with colon transcriptome in mice.

Methods: Dextran sodium sulfate (DSS)-induced experimental colitis was established and fecal microbiota was transplanted by gavage. Read More

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[rCsHscB derived from has therapeutic effect on dextran sodium sulfate-induced chronic ulcerative colitis in mice].

Nan Fang Yi Ke Da Xue Xue Bao 2021 May;41(5):664-670

Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Key Laboratory of Infection and Immunity, Department of Pathogen and Immunology, Xuzhou Medical University, Xuzhou 221004, China.

Objective: To investigate the therapeutic effect of rCsHscB derived from on dextran sodium sulfate (DSS)-induced chronic ulcerative colitis in mice.

Objective: C57BL/6 mice were randomized into negative control (NC) group (= 10), rCsHscB group (=10), DSS group (=15), and DSS+rCsHscB group (=15), and in the latter two groups, chronic ulcerative colitis was induced in the mice using 2% DSS. In rCsHscB and DSS+ rCsHscB groups, the mice received intraperitoneal injections of 125 μg/mL rCsHscB on the 4th and 7th day following DSS administration, and PBS was injected in the other two groups. Read More

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Atypical case of Crohn's colitis in a patient with adult-onset Still's disease.

BMJ Case Rep 2021 Jun 15;14(6). Epub 2021 Jun 15.

Department of Surgery and Anaesthesia, University of Otago Wellington, Wellington, New Zealand.

A 65-year-old woman with a background of adult-onset Still's disease (AOSD) presented acutely to a general surgical unit with signs of bowel obstruction and sepsis. A CT scan was indicative of a mesenteric lymphadenopathy suspicious of malignancy. At the time of the surgery, a clinical diagnosis of lymphoma was made given the large number of lymph nodes; however, histological diagnosis was resulted as Crohn's colitis. Read More

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Fabrication and Evaluation of Celecoxib Oral Oleogel to Reduce the Inflammation of Ulcerative Colitis.

AAPS PharmSciTech 2021 Jun 15;22(5):180. Epub 2021 Jun 15.

Biochemistry Department, Faculty of Pharmacy, October 6 University, 6th of October City, Central Axis, Part 1/1, Behind Sixth October City Authority, Giza, 12585, Egypt.

Oleogel consists of hydrophobic solvent and an oleogelator. In this study, attempts were made to study the influence of Celecoxib solubility, concentration and dispersability on its release, absorption, and biological performance. Oleogels were prepared to study the formulation variables on its stability and release. Read More

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Secretor status strongly influences the incidence of symptomatic norovirus infection in a genotype-dependent manner in a Nicaraguan birth cohort.

J Infect Dis 2021 Jun 15. Epub 2021 Jun 15.

Department of Microbiology and Parasitology, National Autonomous University of Nicaragua - León, León, Nicaragua.

Background: The role of histo-blood group on the burden and severity of norovirus gastroenteritis in young infants has not been well documented.

Methods: Norovirus gastroenteritis was assessed in 443 Nicaraguan children followed from birth until 3 years of age. Stool samples were tested for norovirus by RT-qPCR and histo-blood group antigens (HBGA) were determined by phenotyping of saliva and blood. Read More

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Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii.

Carbohydr Polym 2021 Sep 16;268:118214. Epub 2021 May 16.

Yangzhou Borui Saccharide Biotech Co., Ltd, Yangzhou 225000, Jiangsu, China.

Phellinus baumii is used to treat inflammatory bowel disease (IBD) and gastroenteritis. In this study, a 46 kDa heteropolysaccharide SHPS-1 was isolated from fruiting bodies of P. baumii. Read More

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September 2021

[Reoperation rate and related factors in patients with Crohn's disease].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1683-1689

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To analyze the cumulative reoperation rate of postoperative Crohn's disease (CD) patients and investigate the operation reasons and the effects of drugs on surgical recurrence. Patients with Crohn's disease who had undergone intestinal resection from January 2000 to March 2020 in Peking Union Medical College Hospital were enrolled. Patients were divided into reoperation and non-reoperation group according to whether they had a second operation. Read More

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Co-infection by Salmonella enterica subsp. Enterica serovar typhimurium and Entamoeba dispar pathogenic strains enhances colitis and the expression of amoebic virulence factors.

Microb Pathog 2021 Jun 12;158:105010. Epub 2021 Jun 12.

Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. Electronic address:

Amebiasis is the most severe protozoan infection affecting the human intestine, and the second leading cause of death among parasitic diseases. The mechanisms of amoebic virulence factors acquisition are poorly understood, and there are few studies showing the interaction between Entamoeba dispar and bacteria. Salmonella enterica subsp. Read More

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How does feedback from phage infections influence the evolution of phase variation in Campylobacter?

PLoS Comput Biol 2021 Jun 14;17(6):e1009067. Epub 2021 Jun 14.

Department of Mathematics, University of Leicester, Leicester, United Kingdom.

Campylobacter jejuni (C. jejuni) causes gastroenteritis following the consumption of contaminated poultry meat, resulting in a large health and economic burden worldwide. Phage therapy is a promising technique for eradicating C. Read More

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Changes in Emergency Department Activity and the First COVID-19 Lockdown: A Cross-sectional Study.

West J Emerg Med 2021 May 7;22(3):603-607. Epub 2021 May 7.

Imperial College London, Department of Primary Care and Public Health, Global Digital Health Unit, London, United Kingdom.

Introduction: Emergency department (ED) attendances fell across the UK after the 'lockdown' introduced on 23rd March 2020 to limit the spread of coronavirus disease 2019 (COVID-19). We hypothesised that reductions would vary by patient age and disease type. We examined pre- and in-lockdown ED attendances for two COVID-19 unrelated diagnoses: one likely to be affected by lockdown measures (gastroenteritis), and one likely to be unaffected (appendicitis). Read More

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Trends in respiratory virus circulation following COVID-19-targeted nonpharmaceutical interventions in Germany, January - September 2020: Analysis of national surveillance data.

Lancet Reg Health Eur 2021 Jul 7;6:100112. Epub 2021 Jun 7.

Unit 17: Influenza and Other Respiratory Viruses | German National Influenza Center, Department of Infectious Diseases, Robert Koch-Institute, D-13353 Berlin, Germany.

Background: During the initial COVID-19 response, Germany's Federal Government implemented several nonpharmaceutical interventions (NPIs) that were instrumental in suppressing early exponential spread of SARS-CoV-2. NPI effect on the transmission of other respiratory viruses has not been examined at the national level thus far.

Methods: Upper respiratory tract specimens from 3580 patients with acute respiratory infection (ARI), collected within the nationwide German ARI Sentinel, underwent RT-PCR diagnostics for multiple respiratory viruses. Read More

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