228,363 results match your criteria Gastroenteritis


A photoelectrochemical biosensor for rapid and ultrasensitive norovirus detection.

Bioelectrochemistry 2020 Jul 1;136:107591. Epub 2020 Jul 1.

Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong. Electronic address:

The highly contagious norovirus (NoV) is the most common causative agent of acute gastroenteritis, resulting in >200,000 deaths worldwide annually. A rapid and sensitive detection method is a prerequisite for effective prevention and timely identification of NoV contamination. In the present study, we developed a photoelectrochemical (PEC) biosensor coupled with a novel custom-made monoclonal antibody (mAb) for specific and sensitive NoV detection. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2020.107591DOI Listing

Microbial contamination in drinking water at public outdoor recreation facilities in New Zealand.

J Appl Microbiol 2020 Jul 8. Epub 2020 Jul 8.

mEpiLab, Hopkirk Research Institute, School of Veterinary Sciences, Massey University, Palmerston North, New Zealand.

Aim: The aim of our study was to assess the presence and risk of waterborne pathogens in the drinking water of outdoor facilities in New Zealand and track potential sources of microbial contamination in water sources.

Methods And Results: A serial cross-sectional study with a risk-based sample collection strategy was conducted at 15 public campgrounds over two summer seasons (2011/12 and 2012/13). Drinking water supplied to these campgrounds was not compliant with national standards, based on Escherichia coli as an indicator organism, in more than half of the sampling occasions. Read More

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http://dx.doi.org/10.1111/jam.14772DOI Listing

Doping Control Analysis of Total Arsenic in Equine Plasma.

Drug Test Anal 2020 Jul 7. Epub 2020 Jul 7.

Racing Laboratory, The Hong Kong Jockey Club, Sha Tin Racecourse, Sha Tin, N.T., Hong Kong, China.

Arsenic can be easily found in our surrounding environment. Due to its ubiquitous nature, horse urine and blood invariably contain low levels of arsenic. Nevertheless, inorganic arsenic, despite its general use as a tonic for horses, is an effective doping agent having a deleterious effect due to its ability to induce gastroenteritis. Read More

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http://dx.doi.org/10.1002/dta.2896DOI Listing
July 2020
2.816 Impact Factor

Protozoan infections are under-recognized in Swedish patients with gastrointestinal symptoms.

Eur J Clin Microbiol Infect Dis 2020 Jul 7. Epub 2020 Jul 7.

Clinical Microbiology, Region Jönköping County, Sweden and Department of Health, Medicine and Caring, Linköping University, Linköping, Sweden.

In acute gastroenteritis (GE), identification of the infectious agent is important for patient management and surveillance. The prevalence of GE caused by protozoa may be underestimated in Swedish patients. The purpose was to compare the prevalence of E. Read More

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http://dx.doi.org/10.1007/s10096-020-03974-wDOI Listing

Vaccine-mediated protection against -associated enteric disease.

Sci Adv 2020 Jun 24;6(26):eaba4511. Epub 2020 Jun 24.

Najít Technologies Inc., Beaverton, OR, USA.

and are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, vaccine development has been hampered by the lack of animal models that recapitulate human disease pathogenesis. Here, we describe a naturally occurring -associated diarrhea model in outdoor-housed rhesus macaques. Read More

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http://dx.doi.org/10.1126/sciadv.aba4511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314533PMC

Draft genome sequence data of two bacteria from serogroup C type.

Data Brief 2020 Aug 22;31:105920. Epub 2020 Jun 22.

Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, Malaysia.

is a gram-negative rod-shape bacterium from the family of that can cause a wide range of human disease such as enteric fever, gastroenteritis and bacteremia. Here we sequenced two genomes of bacteria isolated from the host. Genomic DNA of the two isolates were extracted and subjected to whole genome sequencing using Illumina platform. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329923PMC

Polycythemia Vera Presenting With Normal Hemoglobin and Hematocrit: A Rare Variant.

Cureus 2020 Jun 2;12(6):e8404. Epub 2020 Jun 2.

Hematology/Oncology, Brookdale University Hospital and Medical Center, Brooklyn, USA.

Polycythemia vera (PV) is a myeloproliferative neoplasm, and its diagnosis requires elevated hemoglobin level (>16.5 mg/dL in men and >16 mg/dL in women), bone marrow characteristics of PV (hypercellularity for age with trilineage growth), and presence of JAK2 (Janus kinase 2) mutations or subnormal erythropoietin level if JAK2 mutation is not present. There exists a subset of patients with normal hemoglobin and hematocrit due to either from dilution of the blood or from coincidental blood loss anemia but these patients still might have underlying PV. Read More

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http://dx.doi.org/10.7759/cureus.8404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331897PMC

Genome-Scale Metabolic Model Driven Design of a Defined Medium for M1cam.

Front Microbiol 2020 19;11:1072. Epub 2020 Jun 19.

Microbes in Food Chain, Quadram Institute Biosciences, Norwich Research Park, Norwich, United Kingdom.

, the most frequent cause of food-borne bacterial gastroenteritis, is a fastidious organism when grown in the laboratory. Oxygen is required for growth, despite the presence of the metabolic mechanism for anaerobic respiration. Amino acid auxotrophies are variably reported and energy metabolism can occur through several electron donor/acceptor combinations. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318876PMC

Spontaneous remission of infantile spasms following rotavirus gastroenteritis.

Neurol Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatric Neurology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617, Riyue Avenue, Chengdu, 611731, China.

Epileptic seizures might be provoked and/or exacerbated by fever or viral infection in children with epilepsy. However, this is not true for infantile spasms; in this study, we report three cases with infantile spasms became seizure free within 2-5 days following rotavirus gastroenteritis without an exchange or addition of antiepileptic drugs, and hypsarrhythmia evolved to diffuse slow waves or localized spikes on electroencephalography. We propose that the probability regarding the mechanism of spontaneous mitigation is the suppression of immunopathological processes caused by infection, while the possibility of ketogenic effects of diarrhea and intestinal flora recombination after rotavirus gastroenteritis is unlikely. Read More

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http://dx.doi.org/10.1007/s10072-020-04564-6DOI Listing

Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1.

Virus Res 2020 Jul 3:198086. Epub 2020 Jul 3.

Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation.

Reoviruses (respiratory enteric orphan viruses) are nonenveloped viruses with segmented dsRNA genome. Viruses in the family Reoviridae are quite stable in the environment. Recently, they have been identified with various pathologies and physiologic dysfunctions in a wide range of organs and tissues, including the hepatobiliary system, the myocardium, lungs, and endocrine tissues. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198086DOI Listing

A bioinformatic approach to identify core genome difference between Salmonella Pullorum and Salmonella Enteritidis.

Infect Genet Evol 2020 Jul 1:104446. Epub 2020 Jul 1.

Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, China; Jiangsu Key Lab of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, China. Electronic address:

S. Pullorum and S. Enteritidis are closely related in genetic terms, but they show very different pathogenicity and host range. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104446DOI Listing

Maternal respiratory infections in early pregnancy increases the risk of type 1 diabetes.

Pediatr Diabetes 2020 Jul 4. Epub 2020 Jul 4.

Crown Princess Victoria's Children's Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Background/objective: Is exposure to maternal infections and use of antibiotics in the prenatal period associated with increased risk of T1D, regardless of genetic risk?

Methods: Data on infections and use of antibiotics during pregnancy were collected from questionnaires at birth from parents to 16292 children in the All Babies in Southeast Sweden (ABIS) cohort and validated against national diagnosis registers. As of November 2017, 137 ABIS children had developed T1D, 72 boys and 65 girls (0.8 % of the original cohort). Read More

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http://dx.doi.org/10.1111/pedi.13075DOI Listing

A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic.

Am J Med Sci 2020 07 11;360(1):5-34. Epub 2020 May 11.

Departments of Radiology. Electronic address:

Since December 2019, the global pandemic caused by the highly infectious novel coronavirus 2019-nCoV (COVID-19) has been rapidly spreading. As of April 2020, the outbreak has spread to over 210 countries, with over 2,400,000 confirmed cases and over 170,000 deaths. COVID-19 causes a severe pneumonia characterized by fever, cough and shortness of breath. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212949PMC

Risk factors for the recurrence of convulsions with mild gastroenteritis in children.

Seizure 2020 Jun 16;80:192-195. Epub 2020 Jun 16.

Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou, China. Electronic address:

Purpose: To identify risk factors for the recurrence of convulsions with mild gastroenteritis (CwG) in children.

Methods: Altogether, 613 children with CwG admitted to Children's Hospital of Shanxi Province from January 2010 to December 2015 were selected, their clinical data were retrospectively analyzed, and patients were followed up for 4-10 years. Risk factors for the recurrence of CwG were analyzed based on the clinical characteristics of the children. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.06.016DOI Listing

Clinical Severity of Gastroenteritis in Children Hospitalized With Rotavirus Infection Before and Post Introduction of a National Rotavirus Vaccination Program in Australia.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Vaccinology and Immunology Research Trials Unit, Women's and Children's Health Network, North Adelaide, South Australia 5006, Australia.

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http://dx.doi.org/10.1097/INF.0000000000002786DOI Listing

[Radioactive Enteritis and Gut Microecology].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):405-409

Department of Gastrointestinal Surgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine, Tsinghua University,Beijing 102218,China.

Radioactive enteritis(RE)is one of the most serious and common complications of intestinal tract caused by radiotherapy for malignant tumors in abdominal cavity,pelvic cavity,or retroperitoneum.Involved intestinal diseases are widespread,complex,and persistent,which make treatment difficult and ineffective.Short bowel syndrome can develop in some serious cases. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11448DOI Listing

The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.

RNA Biol 2020 Jul 2. Epub 2020 Jul 2.

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore (UOL) , Lahore, Pakistan.

Circular RNAs (circRNAs) are ubiquitously expressed, covalently closed rings, produced by pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity endows 3'-5'-linked circRNAs with stability and resistance to exonucleolytic degradation which raises the question whether circRNAs may be relevant as potential therapeutic targets or agents. High stability in biological systems is the most remarkable property and a major criterion for why circRNAs could be exploited for a range of RNA-centered medical applications. Read More

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http://dx.doi.org/10.1080/15476286.2020.1790198DOI Listing

Dynamic rotation of the protruding domain enhances the infectivity of norovirus.

PLoS Pathog 2020 Jul 2;16(7):e1008619. Epub 2020 Jul 2.

National Institute for Physiological Sciences, Okazaki, Japan.

Norovirus is the major cause of epidemic nonbacterial gastroenteritis worldwide. Lack of structural information on infection and replication mechanisms hampers the development of effective vaccines and remedies. Here, using cryo-electron microscopy, we show that the capsid structure of murine noroviruses changes in response to aqueous conditions. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008619DOI Listing

Opinions and attitudes of Italian healthcare workers towards recommended but not compulsory rotavirus vaccination.

Hum Vaccin Immunother 2020 Jul 2:1-6. Epub 2020 Jul 2.

School of Counselling, Italian Medical Research Institute , Benevento, Italy.

Rotaviruses (RVs) are a leading cause of viral gastroenteritis among children younger than 5. The incidence of RV disease can be reduced through the widespread use of vaccination, but coverage is low in many countries, including Italy. This fact reflects the poor consideration given to the RV vaccine, both by the population and by healthcare workers. Read More

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http://dx.doi.org/10.1080/21645515.2020.1776546DOI Listing

Attribution of Pediatric Acute Gastroenteritis Episodes and Emergency Department Visits to Norovirus GI and GII.

J Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Sections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Norovirus is a leading cause of acute gastroenteritis. With vaccines in development, population-based estimates of norovirus burden are needed to identify target populations, quantify potential benefits, and understand disease dynamics.

Methods: We estimated the attributable fraction (AF) for norovirus infections in children, defined as the proportion of children testing positive for norovirus whose gastroenteritis was attributable to norovirus. Read More

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http://dx.doi.org/10.1093/infdis/jiaa391DOI Listing

Perforated Ileal GIST Associated with Meckel Diverticulum - A Rare Pathological Entity of Surgical Acute Abdomen.

Chirurgia (Bucur) 2020 May-Jun;115(3):404-409

The GIST tumors are very rare entities ( 1% of all tumors). They originate in the Cajal interstitial cells, which are part of the autonomic nervous system of the intestine. Their most common location is the stomach, followed by the small intestine. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.404DOI Listing

Appendiceal Diverticular Disease: A 10-year Retrospective Study of Cases from Tertiary Hospitals in Western Australia.

Chirurgia (Bucur) 2020 May-Jun;115(3):348-356

Appendiceal diverticular disease (ADD) is typically a histological diagnosis. Our paper aims to investigate the implications of ADD compared to acute appendicitis (AA). We conducted a retrospective data collection of patients who had undergone an appen dicectomy in three tertiary hospitals across Western Australia between 2009-2019 and included patients with histopathological diagnoses of ADD and AA. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.348DOI Listing

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis.

Heliyon 2020 Jun 20;6(6):e04248. Epub 2020 Jun 20.

Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.

Background: Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322251PMC

Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response.

Front Immunol 2020 16;11:961. Epub 2020 Jun 16.

Departamento de Biotecnología, Facultad de Ciencias del Mar y Recursos Biológicos, Universidad de Antofagasta, Antofagasta, Chile.

Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all ages. However, young children and older adults are the highest-risk groups, being affected with the greatest rate of hospitalizations and morbidity cases. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308418PMC

Expression of Separate Heterologous Proteins from the Rotavirus NSP3 Genome Segment Using a Translational 2A Stop-Restart Element.

J Virol 2020 Jul 1. Epub 2020 Jul 1.

Department of Biology, Indiana University, Bloomington, Indiana, USA.

The segmented 18.5-kbp dsRNA genome of rotavirus expresses 6 structural and 6 nonstructural proteins. We investigated the possibility of using the recently-developed plasmid-based rotavirus reverse genetics (RG) system to generate recombinant viruses that express a separate heterologous protein, in addition to the 12 viral proteins. Read More

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http://dx.doi.org/10.1128/JVI.00959-20DOI Listing

Kommerell diverticulum - egy ritka betegség ritka szövődményei.

Magy Seb 2020 Jun;73(2):61-68

Szív-, Ér-, és Mellkassebészeti Osztály,HM Egészségügyi Központ Budapest.

Incidence of anomalies of the aortic arch is estimated 1-2 per cent in newborn babies. Lusory artery may arise either from left sided aortic arch in 0.7-2 per cent, or from right sided aortic arch in 0. Read More

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http://dx.doi.org/10.1556/1046.73.2020.2.3DOI Listing

Occurrence of severe rotavirus gastroenteritis in children younger than three years of age before and after the introduction of rotavirus vaccine: a prospective observational study in four pediatric clinics in Shibata City, Niigata Prefecture, Japan.

Hum Vaccin Immunother 2020 Jul 1:1-7. Epub 2020 Jul 1.

Department of Pediatrics, Kawasaki Medical School , Kurashiki, Japan.

In Japan, rotavirus (RV) vaccines have already been introduced but not used for universal vaccination as of 2018. Therefore, we identified cases of severe rotavirus gastroenteritis (RVGE) in children younger than three years of age and investigated the occurrence of infection before and after the introduction of RV vaccines. An ecological study through prospective surveillance was conducted in four pediatric clinics in Shibata City, Niigata Prefecture, Japan, during the 2011 to 2018 RVGE epidemic seasons. Read More

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http://dx.doi.org/10.1080/21645515.2020.1720435DOI Listing

Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States.

Hum Vaccin Immunother 2020 Jul 1:1-9. Epub 2020 Jul 1.

GSK Vaccines , Wavre, Belgium.

The etiology of intussusception (IS), a serious gastrointestinal obstruction, remains unclear. Limited evidence suggests a role for viral infection. We investigated the risk of IS after rotavirus gastroenteritis (RV GE) in the first year of life. Read More

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http://dx.doi.org/10.1080/21645515.2020.1770514DOI Listing

The Effectiveness of Activated Sludge Procedure and UV-C in Norovirus Inactivation in a Tunisian Industrial Wastewater Treatment Plant.

Food Environ Virol 2020 Jul 1. Epub 2020 Jul 1.

Centre of Research and Water Technologies (CERTE), Laboratory of Treatment and Valorisation of Water Rejects (LTVRH), Techno Park of Borj-Cédria, 8020, Borj Cédria, Tunisia.

The molecular detection of Norovirus GI and Norovirus GII in the Tunisian industrial wastewater treatment plant of Charguia I was conducted to test the effectiveness of secondary biological treatment using the activated sludge procedure and the UV-C tertiary treatment radiation using a UV disinfection prototype to upgrade the quality of the purified wastewater. A total of 140 sewage samples were collected from the two lines of sewage treatment procedures. Norovirus GI and Norovirus GII have been found and quantified using Real-Time Reverse Transcription Polymerase Chain Reaction (qRT-PCR) in 66. Read More

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http://dx.doi.org/10.1007/s12560-020-09434-0DOI Listing

Campylobacter-derived ligands induce cytokine and chemokine expression in chicken macrophages and cecal tonsil mononuclear cells.

Vet Microbiol 2020 Jul 24;246:108732. Epub 2020 May 24.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada. Electronic address:

Campylobacter jejuni colonizes the chicken gut at a high density without causing disease. However, consumption of poultry products contaminated with this bacterium causes gastroenteritis in humans. Therefore, it is critically important to reduce the Campylobacter burden in poultry products to prevent transmission to humans. Read More

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http://dx.doi.org/10.1016/j.vetmic.2020.108732DOI Listing

Rotavirus A in Brazil: Molecular Epidemiology and Surveillance during 2018-2019.

Pathogens 2020 Jun 27;9(7). Epub 2020 Jun 27.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Rio de Janeiro 21040-900, Brazil.

Rotavirus A (RVA) vaccines succeeded in lowering the burden of acute gastroenteritis (AGE) worldwide, especially preventing severe disease and mortality. In 2019, Brazil completed 13 years of RVA vaccine implementation (Rotarix™) within the National Immunization Program (NIP), and as reported elsewhere, the use of Rotarix™ in the country has reduced childhood mortality and morbidity due to AGE. Even though both marketed vaccines are widely distributed, the surveillance of RVA causing AGE and the monitoring of circulating genotypes are important tools to keep tracking the epidemiological scenario and vaccines impact. Read More

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http://dx.doi.org/10.3390/pathogens9070515DOI Listing

Metabolic Activation of CsgD in the Regulation of Biofilms.

Microorganisms 2020 Jun 27;8(7). Epub 2020 Jun 27.

Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon S7N 5E3, Canada.

Among human food-borne pathogens, gastroenteritis-causing strains have the most real-world impact. Like all pathogens, their success relies on efficient transmission. Biofilm formation, a specialized physiology characterized by multicellular aggregation and persistence, is proposed to play an important role in the transmission cycle. Read More

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http://dx.doi.org/10.3390/microorganisms8070964DOI Listing

Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines.

Vaccines (Basel) 2020 Jun 27;8(3). Epub 2020 Jun 27.

Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, PO Box 339, Bloemfontein 9300, South Africa.

Safety, efficacy, and cost-effectiveness are paramount to vaccine development. Following the isolation of rotavirus particles in 1969 and its evidence as an aetiology of severe dehydrating diarrhoea in infants and young children worldwide, the quest to find not only an acceptable and reliable but cost-effective vaccine has continued until now. Four live-attenuated oral rotavirus vaccines (LAORoVs) (Rotarix, RotaTeq, Rotavac, and RotaSIIL) have been developed and licensed to be used against all forms of rotavirus-associated infection. Read More

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http://dx.doi.org/10.3390/vaccines8030341DOI Listing

Clinical and Psychological Impact of COVID-19 Infection in Adult Patients with Eosinophilic Gastrointestinal Disorders during the SARS-CoV-2 Outbreak.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy.

Eosinophilic gastrointestinal diseases (EGIDs) are chronic gastrointestinal conditions requiring corticosteroid and immunosuppressive therapy for disease control. Patients with EGIDs usually report impaired quality of life. We aimed to report the clinical and psychological impact of COVID-19 infection in EGID patients. Read More

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http://dx.doi.org/10.3390/jcm9062011DOI Listing

Molecular epidemiology and changes in genotype diversity in of norovirus infections in acute gastroenteritis patients in Huzhou, China, 2018.

J Med Virol 2020 Jun 30. Epub 2020 Jun 30.

Huzhou Center for Disease Control and Prevention, Huzhou, 313000, China.

Background: Norovirus is an important causative agent of acute gastroenteritis worldwide, affecting people of all ages. Stool samples collected from patients with clinical symptoms of acute gastroenteritis in all age groups at the diarrhea outpatient department of the First People's Hospital in Huzhou were analyzed to gain insight into the prevalence and genetic characteristics of norovirus.

Method: From January to December 2018, a total of 551 specimens were screened for norovirus by real-time RT-PCR. Read More

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http://dx.doi.org/10.1002/jmv.26247DOI Listing

Etiology of acute Gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study.

PLoS Negl Trop Dis 2020 Jun 30;14(6):e0008375. Epub 2020 Jun 30.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

Background: Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008375DOI Listing

Antiemetics for Acute Gastroenteritis in Children.

Am Fam Physician 2020 Jul;102(1):51-52

University of Washington Health Science Library, Seattle, WA, USA.

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Pediatric adenovirus gastroenteritis disease severity, viral co-infection and regional seasonal trends in Ireland.

Authors:
Zakaria Barsoum

World J Pediatr 2020 Jun 29. Epub 2020 Jun 29.

South West Acute Hospital-Paediatric Department, 124 Irvinestown Rd, Enniskillen, BT74 6DN, Northern Ireland.

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http://dx.doi.org/10.1007/s12519-020-00381-1DOI Listing

The Percentage of Children Who Developed Type 1 Diabetes After Rotavirus Vaccination-Reply.

JAMA Pediatr 2020 Jun 29. Epub 2020 Jun 29.

Viral Gastroenteritis Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.

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http://dx.doi.org/10.1001/jamapediatrics.2020.1082DOI Listing

Clinical characteristics of preeclampsia in twin versus singleton pregnancies.

J Matern Fetal Neonatal Med 2020 Jun 29:1-5. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, Lis Maternity and Women's Hospital, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

We aimed to compare features of preeclampsia between twin and singleton pregnancies. In this retrospective case-control study, women with twin pregnancies who were diagnosed with preeclampsia were matched to singleton pregnancies controls. Ninety-four women with twin gestation diagnosed with preeclampsia were compared to singleton pregnancies with preeclampsia. Read More

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http://dx.doi.org/10.1080/14767058.2020.1784872DOI Listing

Hawke's Bay pharmacists' activities during a campylobacter contamination of public water supply in Havelock North during 2016.

J Prim Health Care 2020 Jun;12(2):122-128

Vicary Pharmacy Services Limited, Napier, New Zealand.

INTRODUCTION In August 2016 contamination of the local water supply resulted in a significant gastroenteritis outbreak in Hawke's Bay. The significance of the initial test result was recognised early, partly as a result of information provided by a Havelock North pharmacist to health authorities about an unusual number of requests for anti-diarrhoeal medication. AIM To describe the breadth of activities undertaken by pharmacists working in Hawke's Bay in August 2016, following Campylobacter jejuni contamination of the public water supply in Havelock North, New Zealand. Read More

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http://dx.doi.org/10.1071/HC19110DOI Listing

Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na/K-ATPase independent proteolysis.

Biochem Pharmacol 2020 Jun 24:114122. Epub 2020 Jun 24.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.

An unprecedented biological function of natural cardenolides independent of their membrane target Na/K-ATPase is disclosed. Previously, we reported that cardenolides impart anti-transmissible gastroenteritis coronavirus (anti-TGEV) activity through the targeting of Na/K-ATPase and its associated PI3K_PDK1_RSK2 signaling. Swine testis cells with Na/K-ATPase α1 knocked down exhibited decreased susceptibility to TGEV infectivity and attenuated PI3K_PDK1_RSK2 signaling. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314687PMC

Municipal wastewater surveillance reveals high community disease burden of rarely reported and possibly subclinical Derby strain.

Appl Environ Microbiol 2020 Jun 26. Epub 2020 Jun 26.

Department of Civil and Environmental Engineering, University of Hawaii at Manoa, Honolulu, HI 96822

Clinical surveillance of enteric pathogens like is integral to track outbreaks and endemic disease trends. However, clinic-centered disease monitoring biases toward detection of severe cases and underestimates the incidence of self-limiting gastroenteritis and asymptomatic strains. Monitoring pathogen loads and diversity in municipal wastewater (MW) can provide insight into asymptomatic or subclinical infections which are not reflected in clinical cases. Read More

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http://dx.doi.org/10.1128/AEM.00814-20DOI Listing

Spinal epidural abscess caused by non-typhoidal Salmonella: A case report and literature review.

J Infect Chemother 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.

Non-typhoidal Salmonellae are Gram negative bacilli commonly causing self-limiting gastroenteritis, representing a public health issue particularly in tropical countries. Further, the epidemiology of invasive infection by non-typhoidal Salmonella species is poorly understood. Herein, we presented a case of an unusual Salmonella enterica subsp. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.016DOI Listing

Pathogenesis.

EcoSal Plus 2020 Jun;9(1)

Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

is an emerging enteropathogen of humans and many avian species. This bacterium is a close relative of and has been frequently misidentified as enteropathogenic or enterohemorrhagic due to their similarity in phenotypic and genetic features, such as various biochemical properties and the possession of a type III secretion system encoded by the locus of enterocyte effacement. This pathogen causes outbreaks of gastroenteritis, and some strains produce Shiga toxin. Read More

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http://dx.doi.org/10.1128/ecosalplus.ESP-0015-2019DOI Listing

Prevalence and Clinical Management of Non-malarial Febrile Illnesses among Outpatients in the Era of Universal Malaria Testing in Malawi.

Am J Trop Med Hyg 2020 Jun 22. Epub 2020 Jun 22.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.

Increasing access to rapid diagnostic tests for malaria (mRDTs) has raised awareness of the challenges healthcare workers face in managing non-malarial febrile illnesses (NMFIs). We examined NMFI prevalence, clinical diagnoses, and prescribing practices in outpatient clinics across different malaria transmission settings in Malawi. Standardized facility-based malaria surveillance was conducted at three facilities one of every 4 weeks over 2 years. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0800DOI Listing

Liver Abscess and Bacteremia in a Sashimi Lover: A Case Report and Review of the Literature.

Open Forum Infect Dis 2020 Jun 6;7(6):ofaa212. Epub 2020 Jun 6.

Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.

is a foodborne pathogen known to cause a cholera-like gastroenteritis syndrome. Here we report the first case of liver abscess and bacteremia presumed to be from sashimi, a Japanese raw seafood delicacy. We also provide a literature review of reported cases of extra-intestinal diseases including bacteremia. Read More

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http://dx.doi.org/10.1093/ofid/ofaa212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305699PMC

Development and evaluation of a multiplex conventional reverse-transcription polymerase chain reaction assay for detection of common viral pathogens causing acute gastroenteritis.

Diagn Microbiol Infect Dis 2020 Apr 17;97(4):115061. Epub 2020 Apr 17.

Regional Virus Research and Diagnostic Lab (VRDL), ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, WB, India.

Timely identification of etiological agents of enteric infections is necessary to reduce the burden of infantile diarrheal mortality. Nucleic acid amplification-based detection methods offer a quick, reliable way for diagnosis of microbes in clinical specimens. This study was undertaken to evaluate an easy-to-use, cost-effective multiplex conventional reverse-transcription polymerase chain reaction (RT-PCR) assay developed at the Indian Council of Medical Research-National Institute of Cholera and Enteric Diseases virology laboratory to identify 4 common enteric viruses (rotavirus, norovirus, adenovirus, astrovirus) in stool samples from patients who were being evaluated for acute diarrhea. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.115061DOI Listing

Incidence, etiology, and severity of acute gastroenteritis among prospectively enrolled patients in 4 Veterans Affairs hospitals and outpatient centers, 2016-18.

Clin Infect Dis 2020 Jun 25. Epub 2020 Jun 25.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Acute gastroenteritis (AGE) burden, etiology, and severity in adults is not well-characterized. We implemented a multisite AGE surveillance platform in 4 Veterans Affairs Medical Centers (Atlanta, Bronx, Houston and Los Angeles), collectively serving >320,000 patients annually.

Methods: From July 1, 2016-June 30, 2018, we actively identified AGE inpatient cases and non-AGE inpatient controls through prospective screening of admitted patients and passively identified outpatient cases through stool samples submitted for clinical diagnostics. Read More

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http://dx.doi.org/10.1093/cid/ciaa806DOI Listing