216,165 results match your criteria Gastroenteritis


Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study.

Hum Vaccin Immunother 2019 Feb 20:1-9. Epub 2019 Feb 20.

h Medicines Development Division , GSK , Tokyo , Japan.

Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. Read More

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http://dx.doi.org/10.1080/21645515.2018.1564441DOI Listing
February 2019

CHARACTERIZATION OF ENTEROAGGREGATIVE ESCHERICHIA COLI AMONG DIARRHEAL CHILDRENIN WESTERN BRAZILIAN AMAZON.

Arq Gastroenterol 2018 Oct-Dec;55(4):390-396

Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil.

Background: Enteroaggregative Escherichia coli (EAEC) is one of the main acute and chronic diarrhea causes both in children and adults, mainly in developing countries.

Objective: The aim of the present study is to characterize EAEC strains isolated from faecal samples and to identify genes potentially contributing to virulence, biofilm production and antimicrobial resistance in children admitted to a pediatric hospital in Porto Velho, Rondônia State.

Methods: The total of 1,625 E. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-84DOI Listing

Eosinophilic Gastrointestinal Diseases in Childhood.

Ann Nutr Metab 2018 19;73 Suppl 4:18-28. Epub 2019 Feb 19.

Division on Gastroenterology, Hepatology and Nutrition, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens,

Eosinophilic gastrointestinal diseases (EGIDs) comprise a group of chronic, inflammatory diseases of the gastrointestinal (GI) tract, that are characterized, clinically, by symptoms related to the dysfunction of the involved segment(s) of the GI tract, and histologically, by dense eosinophilic inflammation, in the absence of an identifiable secondary cause. The group of EGIDs comprises eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). EoE is the most common and the best described EGID compared to EG, EGE, and EC. Read More

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http://dx.doi.org/10.1159/000493668DOI Listing
February 2019

[Molecular epidemiology of norovirus in children with acute gastroenteritis in Tianjin, China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):139-143

Pediatric Research Institute, Tianjin Children's Hospital, Tianjin 300134, China.

Objective: To investigate the molecular epidemiological characteristics of norovirus (NoV) among children with acute gastroenteritis in Tianjin in 2017.

Methods: A total of 758 stool specimens were collected from the children with acute gastroenteritis possibly caused by viral infection in Tianjin Children's Hospital between January and December, 2017. Quantitative real-time RT-PCR was used for primary screening of NoV, and conventional RT-PCR was used for gene amplification, sequencing and genotype identification of the VP1 region of capsid protein in positive specimens. Read More

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February 2019

Changes in norovirus genotype diversity in gastroenteritis outbreaks in Alberta, Canada: 2012-2018.

BMC Infect Dis 2019 Feb 19;19(1):177. Epub 2019 Feb 19.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

Background: The emergence of norovirus genotype GII.4 variants has been associated with gastroenteritis pandemics worldwide, prompting molecular surveillance for early detection of novel strains. In this study, we aimed to analyze the outbreak activity of norovirus and characterize the norovirus strains circulating in Alberta between July 2012 and February 2018. Read More

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http://dx.doi.org/10.1186/s12879-019-3792-yDOI Listing
February 2019

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019

Genome characterization and temporal evolution analysis of a non-epidemic norovirus variant GII.8.

Infect Genet Evol 2019 Feb 15. Epub 2019 Feb 15.

Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China. Electronic address:

Noroviruses are the primary cause of non-bacterial acute gastroenteritis worldwide, and GII.8 belongs to a non-epidemic genotype with a limited understanding currently. In this study, we assembled the first GII. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.010DOI Listing
February 2019

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

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http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019

Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication.

J Biol Chem 2019 Feb 15. Epub 2019 Feb 15.

Stanford University, United States.

Genome replication and virion assembly of segmented RNA viruses are highly coordinated events, tightly regulated by sequence and structural elements in the UTRs of viral RNA. This process is poorly defined and likely requires the participation of host proteins in concert with viral proteins. In this study, we employed a proteomics-based approach, named RNA-protein interaction detection (RaPID), to comprehensively screen for host proteins that bind to a conserved motif within the rotavirus (RV) 3' terminus. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006004DOI Listing
February 2019

Association Between Repeated Episodes of Gastroenteritis and Mental Health Problems in Childhood and Adolescence.

J Am Acad Child Adolesc Psychiatry 2019 Feb 8. Epub 2019 Feb 8.

Douglas Mental Health University Institute, Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, Quebec, Canada; Sackler Institute for Epigenetics & Psychobiology, McGill University, Quebec, Canada.

Objective: The Avon Longitudinal Study of Parents and Children (ALSPAC) and Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) cohorts were used to determine if repeated exposure to gastroenteritis in early life could predict risk for psychiatric problems in childhood and in ALSPAC adolescents. We determined if inflammatory biomarkers moderate the association between repeated gastroenteritis and mental health in adolescents from ALSPAC.

Method: Episodes of gastroenteritis from birth to 30 and 36 months were reported by mothers. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.01.007DOI Listing
February 2019

Quality of life and its association with irritable bowel syndrome and fatigue ten years after giardiasis.

Neurogastroenterol Motil 2019 Feb 14:e13559. Epub 2019 Feb 14.

Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway.

Background: Gastroenteritis has been associated with complications such as irritable bowel syndrome (IBS) and chronic fatigue (CF). Little is known about the implications for quality of life (QoL) in this setting. The aims of this study were to evaluate the association between exposure to Giardia infection and QoL ten years after the infection, and how this related to IBS and CF. Read More

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http://dx.doi.org/10.1111/nmo.13559DOI Listing
February 2019
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Reduction of hospitalizations with diarrhea among children aged 0-5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine.

Vaccine 2019 Mar 11;37(11):1407-1411. Epub 2019 Feb 11.

Unity of Gastroenteritis, Department of Virology, National Institute of Hygiene, Rabat, Morocco.

Introduction: Rotavirus vaccine was introduced in Mauritania in December 2014. We investigated hospitalizations with diarrhea during pre and post-vaccination periods among children aged 0-5 years in Nouakchott, the capital of Mauritania.

Methods: We conducted a retrospective review of hospital admission registries from November 1st 2012 through October 31th 2017 at all referral hospitals in Nouakchott. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.078DOI Listing

Equity and impact: Ontario's infant rotavirus immunization program five years following implementation. A population-based cohort study.

Vaccine 2019 Feb 9. Epub 2019 Feb 9.

Public Health Ontario, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Background: Ontario implemented a publicly-funded rotavirus (RV) immunization program in 2011. Our objectives were to evaluate its impact on hospitalizations and emergency department (ED) visits for acute gastroenteritis (AGE) five years after implementation.

Methods: We performed a population-based longitudinal retrospective cohort study to identify hospitalizations and ED visits for RV-AGE and overall AGE in all age groups using ICD-10 codes between August 1, 2005 and March 31, 2016. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.061DOI Listing
February 2019

Taxonomy, virulence genes and antimicrobial resistance of Aeromonas isolated from extra-intestinal and intestinal infections.

BMC Infect Dis 2019 Feb 14;19(1):158. Epub 2019 Feb 14.

Center of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Background: Clinical characteristics (taxonomy, virulence genes and antimicrobial resistance ) of Aeromonas in isolated from extra-intestinal and intestinal infections were investigated to describe epidemiology, associated virulence factors and optimal therapy options.

Methods: Clinical samples (n = 115) of Aeromonas were collected from a general hospital in Beijing between the period 2015 and 2017. Taxonomy was investigate by Multilocus phylogenetic analysis (MLPA), 10 putative virulence factors by use of polymerase chain reaction (PCR) and antimicrobial resistance to 15 antibiotics by use of the microbroth dilution method. Read More

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http://dx.doi.org/10.1186/s12879-019-3766-0DOI Listing
February 2019

Intrahost viral evolution during chronic sapovirus infections.

J Clin Virol 2019 Feb 7;113:1-7. Epub 2019 Feb 7.

Institute of Virology, Leipzig University, Leipzig, Germany Johannisallee 30, 04103, Leipzig, Germany.

Background: Sapovirus is a common cause of self-limiting diarrhea. In immunocompromised individuals chronic infections occur, but are incompletely investigated.

Objectives: To investigate viral evolution in immunocompromised hosts during chronic sapovirus infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193002
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http://dx.doi.org/10.1016/j.jcv.2019.02.001DOI Listing
February 2019
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G1P[8] Rotavirus in children with severe diarrhea in the post-vaccine introduction era in Brazil: Evidence of reassortments and structural modifications of the antigenic VP7 and VP4 regions.

Infect Genet Evol 2019 Feb 11;69:255-266. Epub 2019 Feb 11.

Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brazil. Electronic address:

Worldwide rotaviruses A (RVA) are responsible for approximately 215,000 deaths annually among children aged <5 years. RVA G1P[8] remains associated with >50% of gastroenteritis cases in this age group. The aim of this study was to assess the genetic variability of G1P[8] strains detected in children with severe diarrhea in Belém, Pará, Brazil, during the post-rotavirus vaccine introduction era. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.009DOI Listing
February 2019

Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Division of Allergy and Immunology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at The University of Pennsylvania.

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http://dx.doi.org/10.1016/j.jaip.2019.01.053DOI Listing
February 2019
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Abnormal thymic stromal lymphopoietin expression in the gastrointestinal mucosa of patients with eosinophilic gastroenteritis.

J Pediatr (Rio J) 2019 Feb 11. Epub 2019 Feb 11.

Children's Hospital Affiliated to Nanjing Medical University, Department of Gastroenterology, Nanjing, China. Electronic address:

Objective: To investigate the differential expression of the thymic stromal lymphopoietin isoforms, short and long, and discern their biological implications under eosinophilic gastroenteritis.

Methods: The expression of thymic stromal lymphopoietin and its two isoforms in tissues was assessed by quantitative RT-PCR in healthy controls (n=24) and patients with eosinophilic gastroenteritis (n=17).

Results: Thymic stromal lymphopoietin mRNA was significantly reduced in eosinophilic gastroenteritis when compared with healthy controls (p<0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00217557183086
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http://dx.doi.org/10.1016/j.jped.2018.11.012DOI Listing
February 2019
4 Reads

Comparative Evaluation of Seegene Allplex Gastrointestinal, Luminex xTAG Gastrointestinal Pathogen Panel, and BD MAX Enteric Assays for Detection of Gastrointestinal Pathogens in Clinical Stool Specimens.

Arch Pathol Lab Med 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea (Drs Yoo, J. Park, H. K. Lee, and Y.-J. Park); the Department of Laboratory Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea (Mss Yu and K. G. Park and Mr G. D. Lee); and the Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge (Ms Oak).

Context.—: Infectious gastroenteritis is caused by various pathogens, including bacteria, viruses, and parasites.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0002-OADOI Listing
February 2019
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Detection of in blood of llama using a duplex semi-nested PCR assay and its association with cyst infestation.

Heliyon 2018 Nov 13;4(11):e00928. Epub 2018 Nov 13.

Instituto de Patobiología Veterinaria, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA), Argentina.

The protozoon is the causative agent of South American camelid (SAC) sarcocystosis. Infections are characterized by the presence of cysts in muscles which are in size and appearance similar to rice grains. As consumption of insufficiently cooked infected meat produces gastroenteritis, cyst-containing SAC meat is confiscated by sanitary authorities or depreciated with serious economic consequences for SAC breeders. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e00928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286652PMC
November 2018

Human Norovirus: Experimental Models of Infection.

Viruses 2019 Feb 12;11(2). Epub 2019 Feb 12.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. Read More

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http://www.mdpi.com/1999-4915/11/2/151
Publisher Site
http://dx.doi.org/10.3390/v11020151DOI Listing
February 2019
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An Abdominal Aortic Aneurysm, Intramural Thrombus and Moderate Leak in an Asian Man Presenting with Acute Gastroenteritis.

Eur J Case Rep Intern Med 2018 31;5(1):000758. Epub 2018 Jan 31.

Emergency Department, IMC Hospital, Jeddah, Saudi Arabia.

Introduction: Missing a leaking abdominal aortic aneurysm (AAA) is common in medical practice because few at-risk patients have a history of AAA and many have an unusual presentation.

Background: AAA is less common among Asians than white Caucasians of the same age. Our patient had no significant risk factors apart from age and sex and had an unusual presentation. Read More

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http://dx.doi.org/10.12890/2017_000759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346940PMC
January 2018
1 Read

A Case of Eosinophilic Gastroenteritis Associated with Eosinophilic Ascites Diagnosed by Full-Thickness Biopsy of the Small Intestine.

Am J Case Rep 2019 Feb 13;20:189-193. Epub 2019 Feb 13.

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

BACKGROUND Eosinophilic gastroenteritis is a rare disease, characterized by infiltrates of eosinophils in the intestinal mucosa, muscularis propria, and serosa. Eosinophilic gastroenteritis is due to Type 1 hypersensitivity and can be associated with other atopic diseases. The clinical course of eosinophilic gastroenteritis varies depending on the location, extent, and depth of eosinophilic infiltration of the gastrointestinal tract, which can make the diagnosis challenging. Read More

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http://dx.doi.org/10.12659/AJCR.913319DOI Listing
February 2019
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Impact of rotavirus vaccination on rotavirus genotype distribution and diversity in England, September 2006 to August 2016.

Euro Surveill 2019 Feb;24(6)

NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom.

IntroductionRotavirus vaccination with the live-attenuated monovalent (a G1P[8] human rotavirus strain) two-dose Rotarix vaccine was introduced in England in July 2013. Since then, there have been significant reductions in rotavirus gastroenteritis incidence.AimWe assessed the vaccine's impact on rotavirus genotype distribution and diversity 3 years post-vaccine introduction. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1700774DOI Listing
February 2019

A large outbreak of Salmonella enterica serovar Thompson infections associated with chocolate cake in Busan, Korea.

Epidemiol Health 2019 9;41:e2019002. Epub 2019 Jan 9.

Busan Center for Infectious Disease Control and Prevention, Busan National University Hospital, Busan, Korea.

Objectives: This study aimed to reveal the epidemiologic characteristics of the outbreak of gastroenteritis caused by Salmonella enterica serovar Thompson in Busan Metropolitan City and to identify points for improvement to prevent of food-borne disease outbreak.

Methods: This was a case-control study. The control group comprised asymptomatic students in the same classes of the cases. Read More

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http://dx.doi.org/10.4178/epih.e2019002DOI Listing
January 2019

Long-term observation of antimicrobial susceptibility and molecular characterization of Campylobacter jejuni isolated in a Japanese general hospital in Tokyo from 2000 to 2017.

J Glob Antimicrob Resist 2019 Feb 9. Epub 2019 Feb 9.

Department of Microbiology and Infectious Disease, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan.

Objectives: Campylobacter jejuni is one of the most common pathogens causing gastroenteritis. Because there is currently insufficient epidemiological information on the antimicrobial susceptibility and molecular characterization of clinical isolates of C. jejuni in Japan, we carried out antimicrobial susceptibility testing, and MLST of clinical C. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.02.001DOI Listing
February 2019

Concentrations of interleukin-6, 8, 10 and tumour necrosis factor-α in the faeces of dogs with acute diarrhoea.

N Z Vet J 2019 Feb 12:1-10. Epub 2019 Feb 12.

a Faculty of Veterinary and Agricultural Sciences , University of Melbourne , 250 Princes Hwy, Werribee , VIC 3030 , Australia.

Aim: To compare the concentration of faecal cytokines interleukin (IL)-6, -8, -10, and tumour necrosis factor (TNF)-α in dogs with acute diarrhoea with clinically normal (non-diarrhoeic) dogs.

Methods: A total of 14 dogs presenting with acute diarrhoea, and 25 dogs with no history of gastrointestinal signs in the 2 months prior to enrolment, were recruited from two veterinary hospitals in Melbourne, Australia. IL-6, -8, -10, and TNF-α were measured in faecal samples using canine-specific ELISA. Read More

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http://dx.doi.org/10.1080/00480169.2019.1582368DOI Listing
February 2019
2 Reads

Evidence for Household Transmission of Rotavirus in the United States, 2011-2016.

J Pediatric Infect Dis Soc 2019 Feb 7. Epub 2019 Feb 7.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus is a leading cause of acute gastroenteritis (AGE) in children and is highly transmissible. In this study, we assessed the presence of AGE in household contacts (HHCs) of pediatric patients with laboratory-confirmed rotavirus.

Methods: Between December 2011 and June 2016, children aged 14 days to 11 years with AGE were enrolled at 1 of 7 hospitals or emergency departments as part of the New Vaccine Surveillance Network. Read More

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https://academic.oup.com/jpids/advance-article/doi/10.1093/j
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http://dx.doi.org/10.1093/jpids/piz004DOI Listing
February 2019
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A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
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Risk factors for contagious gastroenteritis in adult patients with diarrhoea in the emergency department - a prospective observational multicentre study.

BMC Infect Dis 2019 Feb 11;19(1):133. Epub 2019 Feb 11.

Focused Research Unit in Emergency Medicine, Hospital of Southern Denmark, Kresten Philipsens Vej 15, DK-6200, Aabenraa, Denmark.

Background: Infectious gastroenteritis is common in the emergency department (ED). Patients infected with either Norovirus or toxigenic Clostridium difficile require special isolation procedures. The aims were to describe the aetiology of infectious gastroenteritis in the ED, evaluate whether current isolation procedures, based on clinical judgement are sufficient, and to identify information that might be used to identify patients requiring isolation. Read More

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http://dx.doi.org/10.1186/s12879-019-3754-4DOI Listing
February 2019
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Human Sapovirus among Outpatients with Acute Gastroenteritis in Spain: A One-Year Study.

Viruses 2019 Feb 8;11(2). Epub 2019 Feb 8.

Department of Microbiology and Parasitology, CIBUS-Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Viral agents of human gastroenteritis affect people of all ages across the globe. As a mainly self-limiting disease, it is difficult to evaluate the real prevalence of etiological agents circulating in each region. Many of the analyzed outbreaks are caused by viruses of the family Caliciviridae, especially the genus (NoV). Read More

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http://dx.doi.org/10.3390/v11020144DOI Listing
February 2019

Prevalence, levels and seasonal variations of human enteric viruses in six major rivers in Alberta, Canada.

Water Res 2019 Apr 1;153:349-356. Epub 2019 Feb 1.

Department of Paediatrics, University of Alberta, 1405-87 Ave, Edmonton, AB, T6G 1C9, Canada.

The prevalence and seasonal variation of 7 viruses in 6 major rivers in Alberta were assessed using a combination of qPCR, cell culture and integrated cell culture with qPCR (ICC-qPCR). Water samples were collected monthly from rivers at different sites upstream and downstream of major urban centers. Seven viruses including rotavirus, adenovirus, astrovirus, norovirus, sapovirus, JC virus and enterovirus, were detected in at least one of the water samples at each site using qPCR. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.034DOI Listing
April 2019
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A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Front Immunol 2019 25;10:58. Epub 2019 Jan 25.

Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare condition of primary immunodeficiency disorder. Interleukin-12 receptor β1 (IL12RB1) deficiency, is the most common genetic etiology of MSMD, which is characterized by the selective predisposition to clinical disease caused by weakly-virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines, and environmental non-tuberculous mycobacteria (NTM). To the best of our knowledge, this is the first case of deficiency to be reported from Iraq. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355664PMC
January 2019
1 Read

Diagnostic challenges in late-presenting congenital diaphragmatic hernia: a 16-year experience from tertiary care centre in North India.

Trop Doct 2019 Feb 10:49475519827109. Epub 2019 Feb 10.

3 Professor, Department of Paediatrics, PGIMS, Rohtak, Haryana, India.

With increasing use of ultrasound screening, the prenatal diagnosis of congenital diaphragmatic hernia (CDH) in better resourced areas has become the norm. However, early diagnosis is still not universal in resource-poor settings and late presentations of CDH continue. We retrospectively analysed the medical records of children operated for late-presenting CDH from 2001 to 2016 at our tertiary care centre in North India. Read More

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http://dx.doi.org/10.1177/0049475519827109DOI Listing
February 2019
1 Read

OzFoodNet quarterly report, 1 October to 31 December 2015

Authors:

Commun Dis Intell (2018) 2019 02 1;43. Epub 2019 Feb 1.

Australian Government Department of Health

The Australian Government Department of Health established the OzFoodNet network in 2000 to collaborate nationally to investigate foodborne disease. In each Australian state and territory, OzFoodNet epidemiologists investigate outbreaks of enteric infection. In addition, OzFoodNet conducts studies on the burden of illness and coordinates national investigations into outbreaks of foodborne disease. Read More

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February 2019

An Outbreak of Gastroenteritis Associated with GII.17 Norovirus-Contaminated Secondary Water Supply System in Wuhan, China, 2017.

Food Environ Virol 2019 Feb 9. Epub 2019 Feb 9.

Division of Microbiology, Wuhan Centers for Disease Prevention and Control, No. 24 Jianghan North Road, Wuhan, 430015, Hubei, People's Republic of China.

A gastroenteritis outbreak occurred in a university in May, 2017, Wuhan, China. The epidemiological survey and pathogen analysis were conducted to identify the pathogen and control this outbreak. Feces or anal swabs from individuals, water, and swabs taken from tap surfaces of the secondary water supply system (SWSS) and foods were collected for the detection of viruses and pathogenic enteric bacteria by real-time RT-PCR and culture, respectively. Read More

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http://dx.doi.org/10.1007/s12560-019-09371-7DOI Listing
February 2019
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Seroprevalence for norovirus genogroups GII and GIV in captive non-human primates.

Zoonoses Public Health 2019 Feb 9. Epub 2019 Feb 9.

Faculty of Veterinary Medicine, Università degli Studi di Teramo, Teramo, Italy.

Noroviruses (NoVs) are a major cause of epidemic gastroenteritis in children and adults. Several pieces of evidence suggest that viruses genetically and antigenically closely related to human NoVs might infect animals, raising public health concerns about potential cross-species transmission. The natural susceptibility of non-human primates (NPHs) to human NoV infections has already been reported, but a limited amount of data is currently available. Read More

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http://dx.doi.org/10.1111/zph.12566DOI Listing
February 2019

Impact of long-term storage of clinical samples collected from 1996 to 2017 on RT-PCR detection of norovirus.

J Virol Methods 2019 Feb 5. Epub 2019 Feb 5.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, Georgia, 30333, USA. Electronic address:

Noroviruses are recognized as the leading cause of acute gastroenteritis globally. With improved molecular diagnostics developed over the last two decades, archived clinical specimens are increasingly used to investigate the historic prevalence and molecular epidemiology of human norovirus. Yet the impact of long-term storage on viral integrity in clinical specimens has not been evaluated. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.02.001DOI Listing
February 2019

Molecular epidemiology and host genetics of norovirus and rotavirus infections in Portuguese elderly living in aged care homes.

J Med Virol 2019 Feb 8. Epub 2019 Feb 8.

Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Rua da Junqueira 100, Portugal.

Norovirus (NoV) and rotavirus group A (RVA) are major agents of acute gastroenteritis worldwide. This study aimed to investigate their epidemiological profile in Portuguese elderly living in long-term care facilities and to assess the host genetic factors mediating infection susceptibility. From November 2013 to June 2015, 636 faecal specimens from 169 elderly, mainly asymptomatic, living in nursing homes in Greater Lisbon and Faro district, Portugal, were collected. Read More

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http://dx.doi.org/10.1002/jmv.25425DOI Listing
February 2019

Helicobacter pylori infection and risk of salmonella infection.

Medicine (Baltimore) 2019 Feb;98(6):e14335

Hepatology, Gastroenetrology and Infectious Diseases Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh.

Helicobacter pylori (H pylori) infection is the most frequent infection worldwide and it has been postulated that it predisposes to multiple enteric pathogens and diarrheal diseases. Salmonella infection is common in tropical and under developed communities and is associated with wide range of diseases from gastroenteritis to typhoid fever. This study aimed at detecting the impact of H pylori infection on the incidence of salmonella infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014335DOI Listing
February 2019
3 Reads

Construction and characterization of porcine single-chain fragment variable antibodies that neutralize transmissible gastroenteritis virus in vitro.

Arch Virol 2019 Feb 7. Epub 2019 Feb 7.

Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, School of Agriculture and Biology, Shanghai JiaoTong University, Shanghai, 200240, People's Republic of China.

Transmissible gastroenteritis virus (TGEV) infection causes severe diarrhea in piglets and imposes a significant economic burden on pig farms. Single-chain fragment variable (scFv) antibodies effectively inhibit virus infection and could be a potential therapeutic reagent for preventing disease. In this study, a recombinant scFv antibody phage display library was constructed from peripheral blood lymphocytes of piglets infected with TGEV. Read More

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http://dx.doi.org/10.1007/s00705-019-04156-6DOI Listing
February 2019
1 Read

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
2 Reads

A foodborne outbreak of gastroenteritis caused by Vibrio parahaemolyticus associated with cross-contamination from squid in Korea.

Authors:
Sun-Wha Jung

Epidemiol Health 2018 13;40:e2018056. Epub 2018 Nov 13.

Environmental Health Division, Seoul Metropolitan Government, Seoul, Korea.

Objectives: Water-borne diseases caused by Vibrio parahemolyticus are often known to cause gastritis when raw or undercooked seafood is eaten. It is very rare that Vibrio gastritis caused by ingesting non-seafood products occurs on a large scale. On September 19, 2017, a large-scale Vibrio gastritis occurred after the city residents consumed food at a bazaar held in a welfare center in Jungnang-gu, Seoul. Read More

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http://dx.doi.org/10.4178/epih.e2018056DOI Listing
February 2019

Linear epitope binding antibodies against GII.3 Norovirus exhibit no histo-blood group antigens (HBGAs) blocking effects.

Virus Genes 2019 Feb 6. Epub 2019 Feb 6.

The Sixth People's Hospital of Zhengzhou, No. 29 Jingguangnan Road, Zhengzhou, 450000, People's Republic of China.

Noroviruses are leading cause of acute gastroenteritis worldwide. In our previous study, we established an in vitro histo-blood group antigens (HBGAs) binding blockade assay against GII.3 Norovirus virus like particles (VLPs) with trypsin digestion. Read More

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http://dx.doi.org/10.1007/s11262-019-01644-4DOI Listing
February 2019
1.837 Impact Factor

Genetic Analysis of an Emerging GII.P2-GII.2 Norovirus Associated with a 2016 Outbreak of Acute Gastroenteritis in China.

Virol Sin 2019 Feb 6. Epub 2019 Feb 6.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-019-00084-6DOI Listing
February 2019

Molecular characteristics of a novel recombinant of porcine epidemic diarrhea virus.

Arch Virol 2019 Feb 6. Epub 2019 Feb 6.

Molecular Virology Laboratory, Federal Research Center for Virology and Microbiology, Academician Bakoulova Street, 1, Petushki Area, Volginsky, Vladimir Region, 601125, Russia.

Porcine epidemic diarrhea (PED) is a contagious viral disease in pigs, caused by the coronavirus porcine epidemic diarrhea virus (PEDV). PEDV infection results in significant mortality in piglets in unvaccinated herds. Like many others RNA viruses, PEDV has high evolutionary rate and is prone to genetic mutations. Read More

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http://dx.doi.org/10.1007/s00705-019-04166-4DOI Listing
February 2019

Differentiating Acute Food Protein-Induced Enterocolitis Syndrome From Its Mimics: A Comparison of Clinical Features and Routine Laboratory Biomarkers.

J Allergy Clin Immunol Pract 2019 Feb 25;7(2):471-478.e3. Epub 2018 Oct 25.

Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Background: Food protein-induced enterocolitis syndrome (FPIES) is frequently misdiagnosed and subject to diagnostic delay. Profuse vomiting, the cardinal feature of acute FPIES, may occur in more common pediatric disorders such as gastroenteritis and sepsis.

Objectives: We sought to determine differentiating features at acute presentation between FPIES, gastroenteritis, and sepsis in young children presenting to an emergency department (ED) with profuse vomiting. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.10.020DOI Listing
February 2019
4 Reads

Extensive drug resistant Salmonella enterica serovar Senftenberg carrying bla encoding plasmid p5558 (IncA/C) from India.

Pathog Glob Health 2019 Feb 6:1-7. Epub 2019 Feb 6.

a Department of Clinical Microbiology , Christian Medical College and Hospital , Vellore , India.

Non-typhoidal Salmonella (NTS) are foodborne pathogens that are responsible for self-limiting gastroenteritis in humans. The present study aims at the molecular characterisation and comparative genomics of Salmonella enterica serovar Senftenberg strain P5558 isolated from the pus samples of a patient suffering from stump infection. The isolate was subjected to serotyping and antimicrobial susceptibility test to understand the phenotypical characteristics. Read More

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http://dx.doi.org/10.1080/20477724.2019.1574112DOI Listing
February 2019

Diagnostic determination of Norovirus infection as one of the major causes of infectious diarrhea in HIV patients using a multiplex polymerase chain reaction assay.

Int J STD AIDS 2019 Feb 5:956462418824912. Epub 2019 Feb 5.

2 Clinical Laboratory of Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Although infectious diarrhea is one of the most common complications in human immunodeficiency virus (HIV)-infected patients, robust diagnostic methods for determining potential pathogens are still limited in the clinic. Norovirus, a type of calicivirus, has been shown to be the most common cause of gastroenteritis. Here, we used multiplex polymerase chain reaction as a diagnostic tool to verify Norovirus as the diarrhea-related pathogen in HIV-infected patients with unknown etiological information. Read More

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http://journals.sagepub.com/doi/10.1177/0956462418824912
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http://dx.doi.org/10.1177/0956462418824912DOI Listing
February 2019
4 Reads

Synchronized Orchestration of miR-99b and let-7g Positively Regulates Rotavirus Infection by Modulating Autophagy.

Sci Rep 2019 Feb 4;9(1):1318. Epub 2019 Feb 4.

Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata, WB, India.

Rotavirus (RV), the major etiological agent of viral gastroenteritis in young children, kills over 200 thousand infants each year. In spite of available vaccines, rotaviral diarrhoea is still a major problem in developing countries of Asia and Africa. Therefore, the studies on RV infection and host antiviral responses are warranted. Read More

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http://dx.doi.org/10.1038/s41598-018-38473-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362297PMC
February 2019
1 Read
5.078 Impact Factor