Search Our Scientific Publications & Authors

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland, USA.

Genomic recombination is a crucial mechanism used to generate genetic variation in human noroviruses. Recombinant variants have been increasingly identified and have contributed to sporadic cases and epidemic outbreaks of acute gastroenteritis globally. We report the near-complete genome of a novel recombinant norovirus GII. Read More

Allergol Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Steel Memorial Hirohata Hospital, Himeji, Japan.

Eosinophilic gastrointestinal diseases (EGIDs) are divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), depending on the involved gastrointestinal tract, though both are considered to be chronic Th2-type allergic diseases caused by food or environmental allergens. In development of EoE, refluxed gastric acid may also have an important role. For diagnosis of EGIDs, the presence of symptoms possibly originating from the involved gastrointestinal tract and dense eosinophil infiltration are important factors. Read More

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

Iran J Microbiol 2019 Feb;11(1):31-38

Enteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Background And Objectives: Non-typhoidal Salmonellosis, a zoonotic infection associated with acute gastroenteritis is caused by non-typhoidal salmonellae (NTS). The study was carried out to determine the prevalence of NTS serovars and their antimicrobial resistance along with the presence of the virulence gene ( gene) in poultry samples.

Materials And Methods: This is a prospective cross-sectional study carried out at the Enteric Diseases Division, Kasturba Medical College, Manipal, South India from January 2016- December 2017. Read More

Can Commun Dis Rep 2018 Nov 1;44(11):304-307. Epub 2018 Nov 1.

National Microbiology Laboratory, MB & ON.

Shiga toxin-producing (STEC) are important enteric pathogens responsible for sporadic cases and outbreaks of gastroenteritis. O157:H7/NM (STEC O157) are the most commonly known STEC serotypes but it is now increasingly apparent that non-O157 STEC serotypes have been underreported in the past because they were not part of routine screening in many front-line laboratories. The Canadian Public Health Laboratory Network (CPHLN) has identified the need for improved detection and surveillance of non-O157 STEC and has developed the following recommendations to assist in the decision-making process for clinical and reference microbiology laboratories. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Saitama Medical University, Japan.

No specific endoscopic features for eosinophilic gastroenteritis (EGE) have been reported previously. This study therefore evaluated the endoscopic findings of six patients with EGE. The diagnosis was confirmed based on gastrointestinal symptoms, pathological findings on biopsy, and the absence of other diseases. Read More

J Food Prot 1988 Aug;51(8):663-673

Food Safety Consultation and Training, 2022 Lavista Circle, Tucker, Georgia 30084.

Factors that contributed to outbreaks of foodborne diseases reported in the U.S. from 1977-1982 are identified and classified by disease and place where implicated foods were mishandled. Read More

Euro Surveill 2019 Apr;24(15)

The members of the RotaNet-Italy Study Group who contributed data are listed at the end of this article.

IntroductionGroup A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young children, causing ca 250,000 deaths worldwide, mainly in low-income countries. Two proteins, VP7 (glycoprotein, G genotype) and VP4 (protease-sensitive protein, P genotype), are the basis for the binary RVA nomenclature. Although 36 G types and 51 P types are presently known, most RVA infections in humans worldwide are related to five G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], G9P[8]. Read More

Poult Sci 2019 Apr 16. Epub 2019 Apr 16.

Poultry Production and Product Safety Research Unit, USDA-ARS, AR 72701, USA.

Campylobacter jejuni, a major cause of human gastroenteritis worldwide, is often associated with the consumption of contaminated poultry products. With increasing consumer preference to natural and minimally processed foods, interventions utilizing natural antimicrobials for controlling C. jejuni on poultry products are gaining popularity. Read More

IDCases 2019 27;15:e00527. Epub 2019 Mar 27.

Department of Internal Medicine, Wayne State University, Detroit, MI, United States.

Non-O1, non-O139 (NOVC) are genetically diverse strains that are generally non-pathogenic in healthy hosts. In immunocompromised patients or those with liver disease, NOVC have been shown to cause gastroenteritis, wound infections or sepsis and are often associated with high mortality rates. We report a case of a patient with liver cirrhosis and chronic venous insufficiency who was found to have NOVC bacteremia. Read More

Biomed Environ Sci 2019 Mar;32(3):210-214

Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou 350001, Fujian, China.

Pathogens 2019 Apr 4;8(2). Epub 2019 Apr 4.

Laboratory for Food Safety, Université PARIS-EST, ANSES, F-94701 Maisons-Alfort, France.

Derby (. Derby) is emerging in Europe as a predominant serovar in fattening turkey flocks. This serovar was recorded as being predominant in the turkey sector in 2014 in the United Kingdom (UK). Read More

Int J Infect Dis 2019 Apr 12. Epub 2019 Apr 12.

Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. Electronic address:

Objectives: In this study we investigated an outbreak of Vibrio cholera O1 Ogawa serotype, occurred during December 2014 in Kudat district, situated in Sabah state of the Malaysian part of Borneo.

Methods: Active case detection and contact tracing were done at respective localities by house to house survey. Passive case detection was done among acute gastroenteritis patients attended at various health facilities. Read More

J Food Prot 2019 Apr 15:775-784. Epub 2019 Apr 15.

4 IEH Laboratories and Consulting Group, 15300 Bothell Way N.E., Lake Forest Park, Washington 98155, USA.

Beef and veal products have been vehicles implicated in the transmission of Salmonella enterica, a gastroenteritis-causing bacteria. Recent regulatory samples collected from veal have indicated bob veal, or calves harvested within days of birth, have higher rates of Salmonella than samples collected from formula-fed veal, or calves raised 20 weeks on milk replacer formula before harvest. To investigate this problem, we collected samples from veal calf hides, preevisceration carcasses, and final carcasses at five veal processors that harvested bob or formula-fed veal or both. Read More

Clin Infect Dis 2018 Oct;67(9):1450-1454

Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.

Floods are the most common natural disaster occurring worldwide, with their impact expected to grow in the future due to the effects of climate change and population shift. Floodwaters pose immediate dangers to human health, but also long-term effects resulting from displacement and worsened living conditions. This review examines the health impact of flood disasters, including skin and soft-tissue infections, gastroenteritis, and zoonotic infections such as leptospirosis, and the impact on noncommunicable diseases and health infrastructure. Read More

Front Microbiol 2019 29;10:647. Epub 2019 Mar 29.

Laboratory of Viral Infection I, Department of Infection Control and Immunology, Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Rotavirus A (RVA) is a major cause of gastroenteritis in infants and young children. After vaccine introduction, RVA surveillance has become more important for monitoring changes in genotype distribution, and the semi-nested multiplex-PCR is a popular method for RVA genotyping. In particular, the VP7 primer set reported by Gouvea and colleagues in 1990 is still widely used worldwide as the recommended WHO primer set in regional and national reference RVA surveillance laboratories. Read More

J Lab Physicians 2019 Jan-Mar;11(1):5-10

Department of General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Context: Acute kidney injury (AKI) is an outcome of multiple etiologies and is mostly reversible. Data on its incidence and outcome, particularly from India, are limited.

Aims: To study the etiology, clinical profile, and short-term prognosis in AKI. Read More

J Matern Fetal Neonatal Med 2019 Apr 14:1-131. Epub 2019 Apr 14.

d Neonatal Intensive Care Unit , Ca' Foncello Hospital , Treviso , Italy.

Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE cell-mediated gastrointestinal food allergy that primarily presents in infancy, as early as the first hours of life. FPIES is often misdiagnosed as sepsis, severe gastroenteritis, abdominal surgical emergency or even metabolic, neurologic or cardiac disorders.

Methods: We report two neonatal cases of cow's milk protein (CMP)-induced FPIES masquerading as surgical diseases. Read More

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Background: Eosinophilic gastroenteritis (EGE) is a rare, chronic inflammatory condition of the gastrointestinal tract. Little is known about its natural history and treatment outcomes. The aims of our analysis were to describe clinical presentation, response to current medical treatments, and to evaluate the response of refractory EGE to anti-integrin therapy. Read More

Food Environ Virol 2019 Apr 13. Epub 2019 Apr 13.

Marine Biotechnology and Environment Laboratory, Faculty of Sciences, University Chouaib Doukkali, El Jadida, Morocco.

Norovirus (NoV) is the leading cause of acute viral gastroenteritis outbreaks in the world. These outbreaks are frequently associated with bivalve shellfish consumption, particularly because these products are often eaten raw or only slightly cooked. In Morocco, regulations concerning the acceptable levels of enteric bacteria indicator organisms in these products have been put in place. Read More

Lancet Haematol 2019 Apr 10. Epub 2019 Apr 10.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Background: Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary immunodeficiency characterised by microthrombocytopenia, infections, eczema, autoimmunity, and malignant disease. Lentiviral vector-mediated haemopoietic stem/progenitor cell (HSPC) gene therapy is a potentially curative treatment that represents an alternative to allogeneic HSPC transplantation. Here, we report safety and efficacy data from an interim analysis of patients with severe Wiskott-Aldrich syndrome who received lentiviral vector-derived gene therapy. Read More

J Dairy Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy. Electronic address:

Human rotaviruses represent a major cause of severe diarrheal disease in infants and young children. The limited impact of oral vaccines on global estimates of rotavirus mortality and the suboptimal use of oral rehydration justify the need for alternative prophylactic and therapeutic strategies, especially for immunocompromised hosts. The protective effects of colostrum-the first milk produced during the initial 24 to 48 h after parturition-are well documented in the literature. Read More

Viruses 2019 Apr 11;11(4). Epub 2019 Apr 11.

Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Centre for Disease Control and Prevention, Beijing 102206, China.

We conducted a retrospective analysis of norovirus outbreaks reported to the National Public Health Emergency Event Surveillance System (PHEESS) in China from January 1, 2014 to December 31, 2017. We reviewed all acute gastroenteritis outbreaks ( = 692) submitted to PHEESS to identify the frequency, seasonality, geographic distribution, setting, and transmission mode of outbreaks due to norovirus. A total of 616 norovirus outbreaks resulting in 30,848 cases were reported. Read More

Infect Genet Evol 2019 Apr 9;73:1-6. Epub 2019 Apr 9.

Department of Hygiene and Molecular Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

While conducting rotavirus gastroenteritis surveillance in Vietnam, two G3P[8] rotavirus A specimens possessing an identical short RNA electropherotype were detected. They were RVA/Human-wt/VNM/0232/2016/G3P[8] and RVA/Human-wt/VNM/0248/2016/G3P[8], and recovered from 9 and 23 months old boys, respectively. The patients developed diarrhoea within one-week interval in March 2016 but in places >100 km apart in northern Vietnam. Read More

Viruses 2019 Apr 10;11(4). Epub 2019 Apr 10.

Department of Medical Virology, Faculty of Health Sciences, University of Pretoria,Pretoria 0001, South Africa.

Noroviruses are a major cause of viral gastroenteritis. The burden of the norovirus in lowresourcesettings is not well-established due to limited data. This study reviews the norovirusprevalence, epidemiology, and genotype diversity in lower-middle-income countries (LMIC) andin low-income countries (LIC). Read More

Viruses 2019 Apr 10;11(4). Epub 2019 Apr 10.

Department of Microbiology, School of Medicine, University of Valencia and Clinical Microbiology Service, Hospital Clínico Universitario de Valencia, Instituto de Investigación INCLIVA, 46010 Valencia, Spain.

Group A rotaviruses are a major cause of acute gastroenteritis in children. The diversity and unequal geographical prevalence of rotavirus genotypes have been linked to histo-blood group antigens (HBGAs) in different human populations. In order to evaluate the role of HBGAs in rotavirus infections in our population, secretor status (FUT2+), ABO blood group, and Lewis antigens were determined in children attended for rotavirus gastroenteritis in Valencia, Spain. Read More

Arch Virol 2019 Apr 10. Epub 2019 Apr 10.

Center of Excellence in Emerging and Re-emerging Diarrheal Viruses, Chiang Mai University, Chiang Mai, Thailand.

Little is known about human parechovirus (HPeV) infection in Thailand. The genotype distribution of HPeV strains in children admitted to hospitals with acute gastroenteritis was investigated using polymerase chain reaction (PCR) and nucleotide sequencing of the VP1 region as the detection and genotype identification methods, respectively. Of a total of 2,002 stool samples, 49 (2. Read More

J Virol 2019 Apr 10. Epub 2019 Apr 10.

ICMR-National Institute of Virology, Pune, India

In 2011, ticks were collected from livestock following an outbreak of Crimean Congo Hemorrhagic fever (CCHF) in Gujarat state, India. CCHF-negative tick pools were passaged for virus isolation, and two virus isolates were obtained, designated Karyana virus (KARYV) and Kundal virus (KUNDV) respectively. Traditional RT-PCR identification of known viruses was unsuccessful, but a next-generation sequencing approach identified KARYV and KUNDV as viruses in the family, , and genera, respectively. Read More

J Clin Microbiol 2019 Apr 10. Epub 2019 Apr 10.

Sections of Pediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

: Although enteric multianalyte syndromic panels are increasingly employed, direct comparisons with traditional methods and the inclusion of host phenotype correlations are limited.: 3089 children with gastroenteritis submitted stool, rectal-swab specimens, and clinical data. Primary outcome was bacterial pathogen detection agreement for shared targets between culture and the Luminex xTAG® Gastrointestinal Pathogen Panel (GPP). Read More

An Pediatr (Barc) 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Pediatría, Hospital Clínico Universitario, Santiago de Compostela, España.

Introduction: Vaccines against rotavirus (RV) have been available in Spain since 2006, but they are neither recommended nor financed by the National Health System. Nevertheless, through recommendations of the Spanish Association of Paediatrics vaccination has achieved intermediate coverage.

Material And Methods: A systematic literature review was performed on studies carried out in Spain in the last 12 years (2006-2018) on RV infection and vaccination. Read More

Viruses 2019 Apr 9;11(4). Epub 2019 Apr 9.

Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.

Norovirus (NoV) causes about one-fifth of all cases of foodborne diseases and is a foremost cause of domestically acquired foodborne acute gastroenteritis and outbreaks. NoV infections are often associated with the consumption of contaminated fresh and ready-to-eat produce, fresh and frozen berries, raw/undercooked bivalve mollusks and products which become contaminated during handling. Despite many industrial efforts to control and prevent NoV contamination of foods, the prevalence of NoV in high-risk foodstuffs at retail is still significant. Read More

Mem Inst Oswaldo Cruz 2019 Apr 4;114:e180574. Epub 2019 Apr 4.

Universidade de São Paulo, Instituto de Medicina Tropical, São Paulo, SP, Brasil.

Human sapoviruses (HSaV) are considered important causative agents of acute gastroenteritis in humans worldwide. However, knowledge of the genetic characteristics of the whole genome of HSaV in Brazil is limited. Here we report the complete genome sequences of six HSaVs GI. Read More

Hum Vaccin Immunother 2019 Apr 9. Epub 2019 Apr 9.

b GSK , Avenue Fleming 20, 1300 Wavre , Belgium.

Rotavirus gastroenteritis imposes a heavy burden on low- and middle-income countries. The World Health Organization defines the Eastern Mediterranean region (WHO-EMRO) as a diverse area in terms of socioeconomic status and health indicators. Rotavirus vaccination has been introduced, at least partially, in 19 out of the 22 EM countries; however, vaccine coverage remains low and data on rotavirus disease burden is scarce. Read More

PLoS One 2019 8;14(4):e0215068. Epub 2019 Apr 8.

Parasitology Reference and Research Laboratory, National Centre for Microbiology, Carlos III Health Institute, Majadahonda, Madrid, Spain.

Background: Multiplex molecular panels are relentlessly replacing conventional methods for the detection of enteric pathogens from stool samples in clinical and research laboratories. Here we evaluated four commercial multiplex real-time PCR assays for the detection of Cryptosporidium hominis/parvum, Giardia duodenalis and Entamoeba histolytica.

Methods: The diagnostic performance of the Gastroenteritis/Parasite Panel I (Diagenode), the RIDAGENE Parasitic Stool Panel (R-Biopharm), the Allplex Gastrointestinal Parasite Panel 4 (Seegene) and the FTD Stool Parasites (Fast Track) real-time PCR methods was assessed against a reference panel of 126 well-characterized DNA samples including Cryptosporidium hominis (n = 29), Cryptosporidium parvum (n = 3), Giardia duodenalis (n = 47), Entamoeba histolytica (n = 3), other parasite species (n = 20), and apparently healthy subjects (n = 24). Read More

J Paediatr Child Health 2019 Apr;55(4):483

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Vaccine 2019 May 4;37(19):2554-2560. Epub 2019 Apr 4.

Serum Institute of India Pvt. Ltd., Pune, India. Electronic address:

Background: A lyophilized bovine-human rotavirus reassortant pentavalent vaccine (BRV-PV, Rotasiil®) was licensed in 2016. A liquid formulation of this vaccine (LBRV-PV, Rotasiil - Liquid) was subsequently developed and was tested for non-inferiority to Rotasiil® and for lot-to-lot consistency.

Methods: This Phase II/III, open label, randomized study was conducted at seven sites across India from November 2017 to June 2018. Read More

Vet Microbiol 2019 Apr 6;231:129-138. Epub 2019 Mar 6.

Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China; Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:

Cholesterol 25-hydroxylase (CH25H) has been shown lately to be a host restriction factor that encodes an enzyme, which catalyzes the oxidized form of cholesterol to 25-hydroxycholesterol (25HC). A series of studies have shown that 25HC activity in hosts plays a vital role in inhibiting viral infection. In this study, we explored the antiviral effect of CH25H and 25HC on porcine epidemic diarrhea virus (PEDV), which causes high mortality rates in newborn piglets with severe diarrhea, and considerable financial loss in the swine industry worldwide. Read More

Food Chem 2019 Aug 21;289:708-713. Epub 2019 Mar 21.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Campylobacter jejuni (C. jejuni) is considered one of the most common cause of human gastroenteritis. Aiming to detect C. Read More

J Am Med Dir Assoc 2019 Apr 3. Epub 2019 Apr 3.

Unité d'Aide Méthodologique, CHU de Reims, Reims, France.

Objective: We aimed to study the efficacy of copper as an antimicrobial agent by comparing incidence rates during outbreaks in areas equipped vs not equipped with copper surfaces in a long-term facility for dependent older adults (nursing home).

Design: Prospective observational pilot study in a nursing home.

Setting And Participant: All persons resident in the nursing home belonging to Reims University Hospital, from February 1, 2015 to June 30, 2016, were included. Read More

Brain Dev 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatrics, Japanese Red Cross Society Himeji Hospital, Hyogo, Japan.

Objective: This study was performed to evaluate the efficacy and safety of intravenous phenobarbital (PB) for benign convulsions with mild gastroenteritis (CwG).

Methods: A randomized, single-blind, placebo-controlled trial involving patients with CwG was conducted at the Japanese Red Cross Society Himeji Hospital. Patients with CwG who had experienced two or more seizures were eligible. Read More

J Virol Methods 2019 Apr 2;269:38-42. Epub 2019 Apr 2.

State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:

A multiplex reverse transcription polymerase chain rection (mRT-PCR) was developed for simultaneous detection of four RNA viruses in swine. The conserved target sequences directed to classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis coronavirus (TGEV) were selected based on alignments of genomic sequences and then specific primers were designed. The mRT-PCR assay was developed and evaluated for its specificity and sensitivity. Read More

Indian J Gastroenterol 2019 Apr 4. Epub 2019 Apr 4.

Department of Gastroenterology, S C B Medical College, Cuttack, 753 007, India.

Background And Aim: Post-infection irritable bowel syndrome (PI-IBS) can occur following acute gastroenteritis (AGE). This study was designed to evaluate the incidence and risk factors of PI-IBS following AGE and to validate a PI-IBS risk score.

Methods: This prospective study was performed between September 2014 and October 2016 on AGE patients by documenting their AGE severity and following up after 3 and 6 months to study the development of IBS (ROME III criteria). Read More

Open Forum Infect Dis 2019 Apr 6;6(4):ofz115. Epub 2019 Mar 6.

National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Norovirus is a leading cause of acute gastroenteritis (AGE); however, few data exist on endemic norovirus disease burden among adults. Candidate norovirus vaccines are currently in development for all ages, and robust estimates of norovirus incidence among adults are needed to provide baseline data.

Methods: We conducted active surveillance for AGE among inpatients at a Veterans Affairs (VA) hospital in Houston, Texas. Read More

BMJ Open 2019 Apr 3;9(4):e026251. Epub 2019 Apr 3.

Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.

Objectives: To investigate oral antibiotic prescribing patterns and identify factors associated with antibiotic prescriptions, with the aim of guiding future interventions to reduce inappropriate prescribing.

Design: Retrospective cohort study.

Setting: Database of public health insurance claims in Kumamoto prefecture (Japan). Read More

Am Surg 2019 Mar;85(3):e160-e161

Am Surg 2019 Mar;85(3):284-287

Two of the accepted treatments for symptomatic Zenker's diverticula are open resection of the diverticulum with cricopharyngotomy and transoral, endoscopic diverticuloesophagostomy with cricopharyngotomy. We report our experience with open surgical resection of the diverticulum with repeat cricopharyngotomy in patients with persistent symptoms after endoscopic diverticuloesophagostomy. This is a retrospective review of patients who underwent open surgical resection of the diverticulum, with repeat cricopharyngotomy in patients with persistent symptoms after endoscopic diverticuloesophagostomy. Read More

J Vet Diagn Invest 2019 Apr 4:1040638719841096. Epub 2019 Apr 4.

Institute of Animal Quarantine, Chinese Academy of Inspection and Quarantine, Beijing, China (Yuan, Deng, C Wang, Lv, Lin, Wu).

Advances in molecular testing and microfluidic technologies have opened new avenues for rapid detection of animal viruses. We used a centrifugal microfluidic disk (CMFD) to detect 6 important swine viruses, including foot-and-mouth disease virus, classical swine fever virus, porcine reproductive and respiratory swine virus-North American genotype, porcine circovirus 2, pseudorabies virus, and porcine parvovirus. Through integrating the loop-mediated isothermal amplification (LAMP) method and microfluidic chip technology, the CMFD could be successfully performed at 62℃ in 60 min. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15113

Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin.

Background: We aimed to conduct a meta-analysis to evaluate the efficacy and safety between once daily (OD) and twice daily (BD) regime dosing of mesalazine for mild-to-moderate ulcerative colitis (UC).

Methods: PubMed, Embase, the Cochrane library, and Web of Science from 1990 to November 2018 were investigated. We searched randomized controlled trials (RCTs) comparing OD with BD regime dosing of mesalazine for mild-to-moderate UC. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15087

Department of Pediatric Emergency China Medical University Children's Hospital, China Medical University.

During the acute phase of vomiting, even a small amount of water may not be tolerated by mouth. Early refeeding may cause re-vomiting in patients, whereas late refeeding may result in dehydration and hypoglycemia. Nil per os (NPO) may be generally recommended by primary physicians, but the appropriate NPO duration for these patients is still unclear. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15044

Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.

To assess inflammatory bowel disease (IBD) patients' experience of chronic illness care and the relationship with demographic and healthcare-related characteristics.This cross-sectional survey used the Instrument to Evaluate the EXperience of PAtients with Chronic diseases (IEXPAC) questionnaire to identify parameters associated with a better healthcare experience for IBD patients. IEXPAC questionnaire responses are grouped into 3 factors - productive interactions, new relational model, and patient self-management, scoring from 0 (worst) to 10 (best experience). Read More