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Food Chem 2022 Jun 18;394:133519. Epub 2022 Jun 18.

Marmara University, Department of Nutrition and Dietetics, Istanbul, Turkey. Electronic address:

Poultry is one of the fastest growing industries due to advantages in land use, rapid production and advances in feed technology. The rising trend in the consumption of poultry meat over the last 50 years has also increased concerns about food safety. Campylobacter jejuniis the leading bacterial cause of gastroenteritis, the foremost cause of foodborne deaths. Read More

J Food Prot 2022 Jun 24. Epub 2022 Jun 24.

Chongqing Three Gorges University Tianxing Road 666# CHINA Wanxian 404100.

Vibrio parahaemolyticus is the main foodborne pathogen of acute gastroenteritis in the world. A quantitative microbiological risk assessment (QMRA) was conducted to evaluate the health risk caused by V. parahaemolyticus in shellfish in the costal cities of east China. Read More

Clin Infect Dis 2022 Jun 25. Epub 2022 Jun 25.

Systems Medicine of Infectious Disease (P5), Robert Koch-Institute, Berlin, Germany.

Background: Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track the spread of this and other SARS-CoV-2 variants of concern led to an expansion of genomic sequencing activities in Germany.

Methods: At Robert Koch Institute (RKI), the German National Institute of Public Health, we established the "Integrated Molecular Surveillance for SARS-CoV-2" (IMS-SC2) network to perform SARS-CoV-2 genomic surveillance at the national scale, SARS-CoV-2 positive samples from laboratories distributed across Germany regularly undergo whole-genome sequencing at RKI. Read More

Radiographics 2022 Jun 24:220004. Epub 2022 Jun 24.

From the Department of Radiology (M.Y., A.D.T.A., Z.S.K., M.L.W., J.P.H., S.P.S., J.L.F., S.K.V.) and Department of Laboratory Medicine and Pathology (M.S.T.), Mayo Clinic, 200 2nd St SW, Rochester, MN 55905; and Department of Diagnostic Imaging, National University Health System, Singapore (L.L.S.T.).

Eosinophilic gastrointestinal disorders (EGIDs) are inflammatory conditions of the gastrointestinal tract that are characterized by tissue eosinophilia and end-organ dysfunction or damage. Primary EGIDs are associated with atopy and other allergic conditions, whereas secondary EGIDs are associated with underlying systemic diseases or hypereosinophilic syndrome. Within the spectrum of EGIDs, eosinophilic esophagitis is the most prevalent. Read More

Viruses 2022 Jun 14;14(6). Epub 2022 Jun 14.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII. Read More

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Department of Emergency Medicine, Chang Gung Memorial Hospital at Keelung, Keelung City 204, Taiwan.

The COVID-19 pandemic has affected emergency department (ED) usage. This study examines changes in the number of ED visits for gastrointestinal (GI) bleeding and nonemergency GI conditions, such as acute gastroenteritis (AGE) and constipation, before the pandemic and at the peak and slack periods of the pandemic in Taiwan. This retrospective observational study was conducted at a referral medical center in northern Taiwan. Read More

Diagnostics (Basel) 2022 Jun 2;12(6). Epub 2022 Jun 2.

Clinical Department 5, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Eosinophilic gastroenteritis (EGE) is a subgroup of the eosinophilic gastro-intestinal disorders (EGIDs), characterized by eosinophilic infiltration and chronic inflammation of the gastrointestinal tract. These are rare diseases with still incompletely elucidated causes and mechanisms, with frequently delayed diagnosis and variable outcome. Despite increased interest in eosinophilic diseases in recent years, fewer data have been published on EGE and no standardized diagnostic and therapeutic approach exists. Read More

Andes Pediatr 2022 Apr;93(2):192-198

Hospital San Juan de Dios, Santiago, Chile.

Intestinal Failure (IF) includes the loss of functional intestinal mass and the requirement of long term Parenteral Nutrition (PN) to achieve the development and growth in childhood.

Objective: To evaluate the experience in a specialized unit for pediatric patients with IF, describing the clinical cha racteristics of those admitted from November 2009 to December 2019.

Patients And Method: Retros pective and descriptive review from clinical records of 24 cases that matched the inclusion criteria. Read More

Rev Chilena Infectol 2022 02;39(1):59-69

Hospital Clínico San Borja Arriarán, Chile.

Neutropenic enterocolitis (NEC) is a heterogeneous disease of the gastrointestinal tract with systemic response, that corresponds to a severe and life-threatening clinical condition in immunocompromised patients, especially in childhood cancer. The pathologic features are poorly understood, although its multifactorial cause of NEC is well established and it is associated with the cytotoxic effects of the chemotherapy agents used and recognized by the classic triad of fever, neutropenia, and abdominal pain, secondary to gastrointestinal injuries that alters mucosal permeability and helps intramural bacterial invasion. NEC is truly a clinical challenge that requires an early diagnosis and a multidisciplinary approach including basic laboratory and imagological tests in high complexity centers. Read More

Bioengineered 2022 Apr;13(4):8961-8971

Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Dysfunction of intestinal epithelial cells (IECs) leads to intestinal epithelial barrier damage and critically involves in the pathogenesis and development of ulcerative colitis (UC). Accumulating studies revealed essential functions of non-coding RNAs in UC. LncRNA NEAT1 (long non-coding RNA nuclear paraspeckle assembly transcript 1) is frequently dysregulated in diverse human diseases. Read More

Gut Microbes 2022 Jan-Dec;14(1):2089007

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Beijing, China.

Some serovars of are not or rare found to cause salmonellosis in human. In our clinic-based surveillance, three rare 4,5,12:a:- strains were recovered from three patients with diarrhea. To explore their genetic and epidemiological characteristics and pathogenesis, we conducted whole-genome sequencing, invasion assays in mammalian cells, and virulence assays in an animal model. Read More

Acta Clin Croat 2021 Dec;60(4):731-738

1Zagreb Health Center-Center, Zagreb, Croatia; 2Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia; 3School of Medicine, University of Zagreb, Zagreb, Croatia; 4Division of Interventional Gastroenterology, Dubrava University Hospital, Zagreb, Croatia; 5School of Medicine, University of Rijeka, Rijeka, Croatia; 6Division of Inflammatory Bowel Disease and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia.

Dyspepsia is a disorder characterized by dyspeptic symptoms which are located in the epigastrium and related to digestion of food in the initial part of the digestive system. In functional dyspepsia, unlike organic dyspepsia, there is no underlying organic disease that would cause dyspeptic symptoms. Immune and mucosal function changes, gastric dysmotility, different composition of the gastrointestinal microbiota, and altered central nervous system processing are considered responsible for the onset of the disorder. Read More

Pan Afr Med J 2022 1;41:269. Epub 2022 Apr 1.

Department of Surgery, Potchefstroom Hospital, Potchefstroom, South Africa.

The vitelline circulation connects the fetus and yolk sac in the first few weeks of fetal development. Its components are the vitelline duct, vitelline arteries and vitelline vein. This gradually breaks down as the placenta grows and overtakes the function of yolk sac as the primary nutrition source. Read More

Front Immunol 2022 6;13:865777. Epub 2022 Jun 6.

Translational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. Read More

Front Microbiol 2022 6;13:906238. Epub 2022 Jun 6.

IRSD - Institut de Recherche en Santé Digestive, Université́ de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.

serovars are invasive gram-negative bacteria, causing a wide range of diseases from gastroenteritis to typhoid fever, representing a public health threat around the world. gains access to the intestinal lumen after oral ingestion of contaminated food or water. The crucial initial step to establish infection is the interaction with the intestinal epithelium. Read More

BMC Genom Data 2022 Jun 22;23(1):48. Epub 2022 Jun 22.

Department of Oncology, Jining Hospital of Traditional Chinese Medicine, 3 Huancheng North Road, Jining, 272000, Shandong Province, China.

Background: Colitis-associated colon cancer (CAC) patients have a younger age of onset, more multiple lesions and invasive tumors than sporadic colon cancer patients. Early detection of CAC using endoscopy is challenging, and the incidence of septal colon cancer remains high. Therefore, identifying biomarkers that can predict the tumorigenesis of CAC is in urgent need. Read More

Sci Rep 2022 Jun 22;12(1):10577. Epub 2022 Jun 22.

Department of Medicine, Division of Gastroenterology and Hepatology, Pennsylvania State University College of Medicine, 500 University Drive, M.C. HU33, Hershey, PA, 17033, USA.

Several symptoms have been connected to increased healthcare resource utilization (HRU) in the context of inflammatory bowel disease (IBD), including both Crohn's disease (CD) and ulcerative colitis (UC). This study was designed to investigate the prevalence of IBD-associated symptoms and to determine whether any are independently associated with HRU. We undertook a retrospective analysis of data related to consecutive IBD patient encounters from a tertiary care referral center between 1/1/2015 and 8/31/2019. Read More

Sci Rep 2022 Jun 22;12(1):10595. Epub 2022 Jun 22.

Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, 12622, Egypt.

Musa acuminata (MA) is a popular fruit peels in the world. Non-food parts of the plant have been investigated for their antioxidant and anti-ulcerative colitis activity. Metabolomic approaches were found to be informative as a screening tool. Read More

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):559-564

Department of Immunology and Pathogenic Biology, College of Medicine, Yanbian University, Yanji 133002, China. *Corresponding authors, E-mail:

Inflammatory bowel disease (IBD) is a non-specific intestinal inflammatory disease with slow onset, varying severity and recurrence. Even though the causes of IBD are still unknown, studies have indicated that the pathogenesis of IBD is associated with multiple factors, including environment, genetics, infection and immunity. Autophagy is involved in regulating the immune response of IBD through a variety of ways such as pathogen removal, immune function, regulation of inflammatory signals, or inhibition of inflammasomes. Read More

BMJ Open 2022 Jun 22;12(6):e056982. Epub 2022 Jun 22.

Department of Epidemiology and Biometry, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.

Introduction: Patients with inflammatory bowel diseases (IBD) often report psychological problems, unemployment, disability, sick leave and compromised quality of life. The effect of psychological interventions on health-related outcomes in IBD is controversial as previous reviews faced the obstacle of high heterogeneity among provided multimodular interventions. The heterogeneity can be addressed with network meta-analysis (NMA) and (multi)component NMA (CNMA). Read More

PLoS Comput Biol 2022 06 22;18(6):e1010112. Epub 2022 Jun 22.

Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.

Cell-cell communication is mediated by many soluble mediators, including over 40 cytokines. Cytokines, e.g. Read More

PLoS Negl Trop Dis 2022 Jun 22;16(6):e0010153. Epub 2022 Jun 22.

Department of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Scabies is a global health concern disproportionately affecting vulnerable populations such as refugees and asylum seekers. Greece is a main point of entry in Europe for refugees, but epidemiological data on scabies in this population are scarce. We aimed to describe the epidemiology of scabies, including trends over the study period. Read More

Cochrane Database Syst Rev 2022 06 22;6:CD009092. Epub 2022 Jun 22.

Department of Surgical Gastroenterology , Hvidovre University Hosipital , Copenhagen, Denmark.

Background: Diverticulitis is a complication of the common condition, diverticulosis. Uncomplicated diverticulitis has traditionally been treated with antibiotics, as diverticulitis has been regarded as an infectious disease. Risk factors for diverticulitis, however, may suggest that the condition is inflammatory rather than infectious which makes the use of antibiotics questionable. Read More

JAMA Netw Open 2022 Jun 1;5(6):e2217812. Epub 2022 Jun 1.

Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, United Kingdom.

Importance: Endogenous cortisol levels in children and adolescents during acute illnesses can contribute to the evidence base required to optimize glucocorticoid (GC) stress doses for children and adolescents known to have GC deficiency.

Objective: To identify endogenous cortisol levels during a range of acute illnesses in children and adolescents without GC deficiency from published evidence.

Evidence Review: CINAHL, Cochrane Library, Cochrane Database of Systematic Reviews, Embase, and MEDLINE were searched for studies published between January 1, 2000, and June 30, 2020. Read More

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3989-3994

Department of Internal Medicine, Hisar Intercontinental Hospital, İstanbul, Turkey.

Objective: Insulin resistance is an important risk factor for developing metabolic syndromes that cause morbidity diseases such as diabetes and cardiovascular diseases. Interestingly, in chronic inflammatory diseases, some inflammatory mediators can play, either directly or indirectly, a pivot role in the development of insulin resistance. This can be considered as an additional factor causing increased mortality and morbidity in these patients. Read More

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3911-3918

Department of Radiology, Adnan Menderes University, School of Medicine, Aydın, Turkey.

Objective: In this study, we reviewed the data of patients who presented to the Emergency Department with abdominal pain, underwent ultrasonography (USG) and computed tomography (CT), and were pathologically diagnosed with acute appendicitis and non-appendicitis. We aimed to emphasize the ethical importance of specifying a clinical diagnosis with its effect on radiologically correct diagnosis and patient management method.

Patients And Methods: A total of 1047 patients, 971 patients with acute appendicitis due to pathology, and 76 patients with non-acute appendicitis, who applied to the Emergency Department with acute abdominal pain, underwent ultrasound and/or CT of the whole abdomen were evaluated. Read More

Arq Bras Cir Dig 2022 17;35:e1657. Epub 2022 Jun 17.

Department of Surgery, Hospital "Dr. José J Aguirre", Faculty of Medicine, University of Chile, Santos Dumont 999, Santiago, Chile.

Aim: Laparoscopic Roux-en-Y gastric bypass (LGB) is the recommended procedure for morbidly obese patients with gastroesophageal reflux disease (GERD). However, there have been reported gastroesophageal reflux symptoms or esophagitis after LGB. Few functional esophageal studies have been reported to date. Read More

Arq Bras Cir Dig 2022 17;35:e1653. Epub 2022 Jun 17.

Santa Marcelina Hospital , Coloproctology Unit- São Paulo - SP - Brazil.

Aim: Inflammatory bowel diseases present progressive and potentially debilitating characteristics with an impact on health-related quality of life (QoL) throughout the course of the disease, and this parameter may even be used as a method of evaluating response to treatment. The aim of this study was to analyze epidemiological data, medications in use, previous surgeries, and hospitalizations in patients with inflammatory bowel diseases, and to determine the impairment in QoL of these patients.

Methods: This is a prospective, cross-sectional, observational study in patients with inflammatory bowel disease followed up in a tertiary hospital in São Paulo-SP, Brazil. Read More

Cancer 2022 Jul;128(14):2689

JCI Insight 2022 Jun 22;7(12). Epub 2022 Jun 22.

Department of Microbiology and Immunology.

Immunosuppressed patients with inflammatory bowel disease (IBD) generate lower amounts of SARS-CoV-2 spike antibodies after mRNA vaccination than healthy controls. We assessed SARS-CoV-2 spike S1 receptor binding domain-specific (S1-RBD-specific) B lymphocytes to identify the underlying cellular defects. Patients with IBD produced fewer anti-S1-RBD antibody-secreting B cells than controls after the first mRNA vaccination and lower amounts of total and neutralizing antibodies after the second. Read More