8,263 results match your criteria Gastritis and Peptic Ulcer Disease


Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome.

Sci Rep 2020 Jul 10;10(1):11409. Epub 2020 Jul 10.

Chair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Faculty of Medicine, LMU Munich, Munich, Germany.

Helicobacter pylori is a gram-negative, spiral-shaped bacterial pathogen and the causative agent for gastritis, peptic ulcer disease and classified as a WHO class I carcinogen. While the prevalence of H. pylori infections in Africa is among the highest in the world, the incidence of gastric cancer is comparably low. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-66128-0DOI Listing

The Use of C-Urea Breath Test for Non-Invasive Diagnosis of Infection in Comparison to Endoscopy and Stool Antigen Test.

Diagnostics (Basel) 2020 Jul 3;10(7). Epub 2020 Jul 3.

Deapartment of Pathology, Microbiology and Forensic Medicine, Jordan University, Amman 11924, Jordan.

() can cause gastritis, peptic ulcer diseases and gastric carcinoma. Endoscopy as the gold standard method of diagnosis is an invasive procedure that might not be suitable in all scenarios. Therefore, this first study in Jordan aimed to assess the non-invasive C urea breath test (UBT) and stool antigen test for diagnosis of infection and the successfulness of eradication therapy as alternatives for endoscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics10070448DOI Listing

The relationship between Helicobacter pylori and chronic kidney disease: update 2020.

Minerva Gastroenterol Dietol 2020 Jul 3. Epub 2020 Jul 3.

Renal Transplantation Center "A. Vercellone", Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S1121-421X.20.02729-4DOI Listing

Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study.

Oncol Rep 2020 Jun 19. Epub 2020 Jun 19.

Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201801, P.R. China.

Certain conflicting conclusions have been drawn that gastric xanthelasma is related to H. pylori, atrophic gastritis, intestinal metaplasia, and early gastric cancer. The aim of this study was to examine the relationship between gastric xanthelasma and upper gastrointestinal (GI) endoscopic or pathological features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2020.7651DOI Listing

An improved quantitative real-time polymerase chain reaction technology for Helicobacter pylori detection in stomach tissue and its application value in clinical precision testing.

BMC Biotechnol 2020 Jun 22;20(1):33. Epub 2020 Jun 22.

Department of Clinical Microbiology and Immunology, Faculty of Pharmacy and Medical Laboratory Sciences, Third Military Medical University (Army Medical University), No. 30 Gaotanyan Street, Chongqing, 400038, People's Republic of China.

Background: Helicobacter pylori (H. pylori) infection is a serious human health threat. The empiric H. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12896-020-00624-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310109PMC

Analysis of the Relation between Periodontitis and Chronic Gastritis/Peptic Ulcer: A Cross-Sectional Study Using KoGES HEXA Data.

Int J Environ Res Public Health 2020 Jun 18;17(12). Epub 2020 Jun 18.

Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea.

The aim of the present study was to investigate the association between periodontitis and chronic gastritis/peptic ulcer using a cross-sectional study design. The present prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study (KoGES) recorded from 2004 to 2016. Among 173,209 participants, 9983 with periodontitis and 125,336 with no periodontitis were selected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17124387DOI Listing

Virulence of Helicobacter pylori outer membrane proteins: an updated review.

Eur J Clin Microbiol Infect Dis 2020 Jun 17. Epub 2020 Jun 17.

Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-020-03948-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299134PMC

Epidemiological investigation of infection in elderly people in Beijing.

World J Clin Cases 2020 Jun;8(11):2173-2180

Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: The () infection rate in China is approximately 50%. is a pathogenic factor of peptic ulcer and chronic gastritis. In addition, infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction, having deleterious effect on their health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v8.i11.2173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281052PMC

Primary Resistance Pattern of to Antibiotics in Adult Population: A Systematic Review.

Infect Drug Resist 2020 28;13:1567-1573. Epub 2020 May 28.

Clinical Pharmacy Unit, School of Pharmacy, College of Health Science, Mekelle University, Mekelle, Ethiopia.

Background: is a spiral-shaped gram-negative bacteria associated with peptic ulcer, gastritis and gastric cancer. The global burden and occurrence of infection remains prevalent and worldwide. Despite this, the trend of the bacterial resistance is not recently studied which can help in the adoption of global, regional and local prevention strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IDR.S250200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266407PMC

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen.

Emerg Med Int 2020 14;2020:7925975. Epub 2020 May 14.

Kilis State Hospital, Emergency Room, Kilis, Turkey.

Aim: The aim of this study was to evaluate the diagnostic value of serum ischemia-modified albumin (IMA) levels in patients presenting to the emergency department with acute abdominal pain and its use in differentiating acute surgical abdomen.

Methods: This single-center prospective cross-sectional study included 334 adult patients who presented to the emergency department. These consisted of 194 patients (Group 1) with nontraumatic abdominal pain commencing in the preceding week, who were definitely diagnosed and either hospitalized in a specific department or planned for discharge, and a control group of 140 patients (Group 2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7925975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244959PMC

Association of Interleukin-1B gene Polymorphism with infected Dyspeptic Gastric Diseases and Healthy Population.

Pak J Med Sci 2020 May-Jun;36(4):825-830

Prof. Dr. Tahir Zahoor, Post Doc, Director, General National Institute of Food Sciences and Technology, University of Agriculture, Faisalabad, Pakistan.

Objective: The aim of study was to investigate the association of IL 1B gene polymorphism with involvement of and other gastric diseases.

Methods: Blood samples of dyspeptic patients were collected from endoscopy department of Allied Hospital Faisalabad from January 2017 to January 2019 and were qualitatively assayed for serological detection of CagA antibodies. PCR followed by direct sequencing was performed for proinflammatory IL-1B gene polymorphism detection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12669/pjms.36.4.1883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260888PMC

The Use of Pistacia Lentiscus Chia Resin Versus Omeprazole in Protecting Male Rats Peptic Mucosa Against Cold Restraint Stress.

J Crit Care Med (Targu Mures) 2020 Apr 6;6(2):100-110. Epub 2020 May 6.

Democritus University of Thrace Faculty of Medicine Alexandroupolis, Alexandroupolis Greece.

Introduction: Peptic mucosal damage induced by acute stress is a serious cause of morbidity and mortality in critically ill patients. The study aimed to investigate the protective, antioxidant and anti-inflammatory effects of pretreatment with Chios mastic gum (CMG), a traditionally consumed herbal resin naturally deriving from the trunk of Pistacia Lentiscus var. Chia compared to Omeprazole, a standard medication used in the prevention and treatment of gastritis, against the effects of cold restraint stress (CRS) in rat gastric and colonic mucosa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jccm-2020-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216028PMC

Ulcerative reflux esophagitis associated with Clostridium ventriculi following hiatoplasty - is antibiotic treatment necessary? A case report.

Z Gastroenterol 2020 May 11;58(5):456-460. Epub 2020 May 11.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

Clostridium (C.) ventriculi (known as Sarcina ventriculi) is a ubiquitous gram-positive, anaerobic, acidophilic coccus found in patients with gastric motility disorders. The microorganisms can be identified histologically by their characteristic presentation in tetrads or packets of 8 in hematoxylin and eosin stains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1123-7984DOI Listing

Enhanced Frequency of CD19IL-10B Cells in Human Gastric Mucosa Infected by Helicobacter pylori.

Am J Med Sci 2020 06 5;359(6):347-353. Epub 2020 Apr 5.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

Background: CD19IL-10B cells are considered as a particular subset of immunosuppressive cells by producing interleukin 10 (IL-10), which plays an important role in infectious and autoimmune diseases. The aim of this study was to determine the number of CD19IL-10B cells in Helicobacter pylori (H. pylori) positive patients in comparison with H. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjms.2020.03.019DOI Listing

Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer.

Sci Rep 2020 Apr 16;10(1):6570. Epub 2020 Apr 16.

Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, MI, USA.

Helicobacter pylori (HP) colonizes the human stomach and induces acute gastritis, peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma. Increased virulence in HP isolates derives from harboring the cag (cytotoxin-associated genes) pathogenicity island (cagPAI). We analyzed the microvariants in cagPAI genes with the hypothesis that they may play an important role in determining HP virulence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-63463-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162905PMC

Risk of stomach cancer incidence in a cohort of Mayak PA workers occupationally exposed to ionizing radiation.

PLoS One 2020 15;15(4):e0231531. Epub 2020 Apr 15.

Clinical Department, Southern Urals Biophysics Institute (SUBI), Ozyorsk, Chelyabinsk region, Russia.

Stomach cancer is a widespread health condition associated with environmental and genetic factors. Contribution of ionizing radiation to stomach cancer etiology is not sufficiently studied. This study was aimed to assess an association of the stomach cancer incidence risk with doses from occupational radiation exposure in a cohort of workers hired at main Mayak production association facilities in 1948-1982 taking into account non-radiation factors including digestive disorders. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159243PMC

Community pharmacy-based screening for patients with uninvestigated dyspepsia.

Can Pharm J (Ott) 2020 Mar-Apr;153(2):101-107. Epub 2020 Feb 18.

Leslie Dan Faculty of Pharmacy (Papastergiou, Donnelly, Yeung), University of Toronto.

Background: is identified by the World Health Organization as a major risk factor of gastritis, peptic ulcer disease and gastric carcinomas. As point-of-care screening technology becomes more widely available, pharmacists are ideally suited to use this tool to screen patients with infection.

Purpose: The objective of this study was to evaluate the feasibility of implementing point-of-care screening technology for into community pharmacy practice and to assess the number of patients who are positively identified as a result of testing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1715163520903065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079325PMC
February 2020

Relationship between Genotypes Infection and IL-10 and TGFβ1 Genes' Expression in Gastric Epithelial Cells.

Int J Prev Med 2020 17;11:20. Epub 2020 Feb 17.

Liver and Digestive Research Center, Reaserch Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: The correlation of infection with gastritis, peptic ulcer, and gastric cancer has been proven. The aim of this study was to determine the effects of and genotypes of on genes expression of interleukin (IL) -10 and tumor growth factor (TGF) β1 in gastric epithelial cells of patients with gastritis and infection.

Methods: In all, 45 gastric biopsy samples were collected from patients with gastritis and infection admitted to Tohid Hospital in Sanandaj city. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijpvm.IJPVM_536_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050228PMC
February 2020

Helicobacter pylori: A Review of Current Diagnostic and Management Strategies.

Dig Dis Sci 2020 Jul;65(7):1917-1931

Division of Gastroenterology and Hepatology, UC Davis Medical Center, University of California Davis School of Medicine, 4150 V Street, Suite 3500, Sacramento, CA, 95817, USA.

As one of the most prevalent infections globally, Helicobacter pylori (H. pylori) continues to present diagnostic and therapeutic challenges for clinicians worldwide. Diagnostically, the "test-and-treat" strategy is the recommended approach for healthcare practitioners when managing this potentially curable disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-020-06193-7DOI Listing

High Cost for Low Yield: A Systematic Review and Meta-Analysis to Assess Cost of Routine Preoperative Esophagogastroduodenoscopy Before Bariatric Surgery.

J Clin Gastroenterol 2020 May/Jun;54(5):398-404

Division of Gastroenterology, Washington University School of Medicine.

Routine esophagogastroduodenoscopy (EGD) is an area of continued controversy in the preoperative evaluation for bariatric surgery; more information is needed regarding its impact on surgical management and associated costs. This systematic review and meta-analysis reports rates of abnormalities detected on preoperative EGD that changed operative management or delayed bariatric surgery. Sensitivity analysis examined the impact of controversial findings of hiatal hernia, Helicobacter pylori, gastritis, peptic ulcer disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCG.0000000000001334DOI Listing

High expression of Helicobacter pylori VapD in both the intracellular environment and biopsies from gastric patients with severity.

PLoS One 2020 12;15(3):e0230220. Epub 2020 Mar 12.

Facultad de Medicina, Departamento de Microbiología y Parasitología, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Helicobacter pylori is a Gram-negative bacterium that causes chronic atrophic gastritis and peptic ulcers and it has been associated with the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT). One of the more remarkable characteristics of H. pylori is its ability to survive in the hostile environment of the stomach. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230220PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067408PMC
June 2020
3.234 Impact Factor

Reevaluation of the Efficacy of First Line Regimen for .

Clin Exp Gastroenterol 2020 22;13:25-33. Epub 2020 Jan 22.

Department of Medicine, BronxCare Health System, Bronx, NY 10457, USA.

Background: is a common cause of gastritis, peptic ulcer disease, and non-ulcer dyspepsia, and is also associated with gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. Despite being known about for more than 30 years, finding an effective therapeutic strategy against it remains a challenge.

Aim: There are no US studies evaluating the efficacy of a Levofloxacin based therapy for infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CEG.S239343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985979PMC
January 2020

[The state and role of esophagus, stomach, intestinal microbiota in patients with ulcer disease, chronic gastritis, esophagitis.]

Klin Lab Diagn 2020 ;65(1):42-49

Tver State Medical University, 170100, Tver, Russia.

The microflora of 64 biopsies taken during fibrogastroduodenoscopy of the mucous membrane of the esophagus, stomach and duodenum in healthy volunteers and 1120 samples obtained from the same parts of the digestive tract in patients with esophagitis, chronic gastritis and peptic ulcer disease were studied. The patients ranged in age from 18 to 62 years. Traditional bacteriological method was used to isolate and identify microorganisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2020-65-1-42-49DOI Listing

Synergistic Effect of and Against Clinical Isolates and Gastritis.

Front Pharmacol 2020 20;11. Epub 2020 Feb 20.

Industrial Bioresource Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.

is one of the most widespread infections involved in the pathogenesis of chronic gastritis, peptic ulcer, and gastric cancer. Hence, there is an urgent need to develop medications against . This study aimed to evaluate synergistic effect of (RF) and Hance (UL) against . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2020.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044145PMC
February 2020

Precancerous Gastric Lesions with /2/ Genotype Increase the Risk of Gastric Cancer.

Biomed Res Int 2020 18;2020:7243029. Epub 2020 Feb 18.

School of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

Objective: The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of (), host genetic susceptibility, and host immune responses. This study investigated the presence of , , 2, 2, and genes and their association with clinical outcomes.

Methods: Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7243029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049835PMC
February 2020

Bezoar in upper gastrointestinal endoscopy: A single center experience.

Turk J Gastroenterol 2020 Feb;31(2):85-90

Department of Gastroenterology, Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Background/aims: We aimed to investigate the association of bezoar with endoscopic findings, risk factors for bezoar occurrence, and the success of endoscopic treatment in a tertiary center.

Materials And Methods: This retrospective study was conducted between January 2012 and December 2015. Overall, 8200 endoscopy records were examined and 66 patients with bezoar were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/tjg.2020.18890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062142PMC
February 2020

Factors associated with failure of eradication.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Jan;45(1):79-84

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China.

() infection is closely related to chronic active gastritis, peptic ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer, and is also associated with some parenteral diseases. Eradication of can significantly improve gastric mucosal inflammatory response, prevent or delay gastric mucosal atrophy, intestinal metaplasia and its development, partially reverse atrophy, and reduce the risk of gastric cancer in varying degrees. In recent years, the eradication failure rate has increased. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180730DOI Listing
January 2020

Upper Gastrointestinal Bleeding in Adults: Evaluation and Management.

Am Fam Physician 2020 03;101(5):294-300

Medical College of Georgia at Augusta University, Augusta, GA, USA.

Upper gastrointestinal (GI) bleeding is defined as hemorrhage from the mouth to the ligament of Treitz. Common risk factors for upper GI bleeding include prior upper GI bleeding, anticoagulant use, high-dose nonsteroidal anti-inflammatory drug use, and older age. Causes of upper GI bleeding include peptic ulcer bleeding, gastritis, esophagitis, variceal bleeding, Mallory-Weiss syndrome, and cancer. Read More

View Article

Download full-text PDF

Source

Preoperative Upper-GI Endoscopy Prior to Bariatric Surgery: Essential or Optional?

Obes Surg 2020 Jun;30(6):2076-2084

Department of Abdominal, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, D-04103, Leipzig, Germany.

Introduction: The role of preoperative upper-gastrointestinal (GI) gastroscopy has been discussed with controversy in bariatric surgery. The aim of this study was to evaluate the incidence of upper-GI pathologies detected via endoscopy prior to bariatric surgery along with their clinical significance for patients' management.

Material And Methods: In our single center prospectively established database of obese patients, who underwent bariatric surgery from January 2011 to December 2017, we retrospectively analyzed the perioperative endoscopic findings along with their influence on patients' management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11695-020-04485-5DOI Listing
June 2020
3.747 Impact Factor

Giant phytobezoar; an unusual cause of gastric outlet obstruction: A case report with literature review.

Int J Surg Case Rep 2020 7;67:154-156. Epub 2020 Feb 7.

Kscien Organization, Hamdi Str. Azadi Mall, Sulaimani, Kurdistan Region, Iraq.

Introduction: Phytobezoar which is described as an undigested or incompletely digested food. It is an odd cause of gastric outlet obstruction (GOO). The aim of this study is to present and discuss a case of GOO caused by multiple giant bezoars. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021519PMC
February 2020

Evaluation of cell-penetrating peptide-peptide nucleic acid effect in the inhibition of A in .

Acta Microbiol Immunol Hung 2020 Feb 11:1-7. Epub 2020 Feb 11.

Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.

is the most common cause of chronic infection in human and is associated with gastritis, peptic ulcer disease, and adenocarcinoma of mucosa-associated lymphoid tissue cells. Peptide nucleic acid (PNA) is a synthetic compound, which can inhibit the production of a particular gene. This study aimed to investigate the effect of PNA on inhibiting the expression of A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/030.66.2019.032DOI Listing
February 2020
0.778 Impact Factor

Epstein-Barr Virus and Co-Infection in Non-Malignant Gastroduodenal Disorders.

Pathogens 2020 Feb 6;9(2). Epub 2020 Feb 6.

Faculty of Health Sciences, Kanazawa University, Kodatsuno 5-11-80, Kanazawa 920-0942, Ishikawa, Japan.

Epstein-Barr virus (EBV) and () are two pathogens associated with the development of various human cancers. The coexistence of both microorganisms in gastric cancer specimens has been increasingly reported, suggesting that crosstalk of both pathogens may be implicated in the carcinogenesis process. Considering that chronic inflammation is an initial step in the development of several cancers, including gastric cancer, we conducted a systematic review to comprehensively evaluate publications in which EBV and co-infection has been documented in patients with non-malignant gastroduodenal disorders (NMGDs), including gastritis, peptic ulcer disease (PUD), and dyspepsia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens9020104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168260PMC
February 2020

Eradication of : the power of nanosized formulations.

Nanomedicine (Lond) 2020 02 7;15(5):527-542. Epub 2020 Feb 7.

Innovative Drug Research Center (IDRC), School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, PR China.

is a pathogen that is considered to cause several gastric disorders such as chronic gastritis, peptic ulcer and even gastric carcinoma. The current therapeutic regimens mainly constitute of a combination of several antimicrobial agents and proton pump inhibitors. However, the prevalence of antibiotic resistance has been significantly lowering the cure rates over the years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/nnm-2019-0329DOI Listing
February 2020

Presence of genes and characterization of s, i and m regions in isolated from Alaskans and their association with clinical pathologies.

J Med Microbiol 2020 Feb 3;69(2):218-227. Epub 2020 Feb 3.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA.

Gastric cancer is a health disparity in the Alaska Native people. The incidence of infection, a risk factor for non-cardia gastric adenocarcinoma, is also high. Gastric cancer is partially associated with the virulence of the infecting strain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jmm.0.001123DOI Listing
February 2020

elicits B7H3 expression on gastric epithelial cells: Implications in local T cell regulation and subset development during infection.

Clin Oncol Res 2019 10;2(5). Epub 2019 Oct 10.

Department of Pediatrics, University of Texas Medical Branch.

() is a gram negative bacterium that infects more than 50% of humanity and is associated with gastritis, peptic ulcer and gastric cancer. Although CD4 T cells are recruited to the gastric mucosa, the host is unable to clear the bacteria. Previously, we demonstrated that infection upregulates the expression of the T cell co-inhibitory molecule B7-H1 while simultaneously downregulating the expression of T cell co-stimulatory molecule B7-H2 on gastric epithelial cells (GEC), which together affect the Treg and Th17 cell balance and foster bacterial persistence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31487/j.cor.2019.05.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988449PMC
October 2019

Gastric Cancer in History: A Perspective Interdisciplinary Study.

Cancers (Basel) 2020 Jan 22;12(2). Epub 2020 Jan 22.

Department of Interdisciplinary Medicine, University of Bari, General Hospital, Bari, Italy.

Background: Gastric adenocarcinoma is the fourth most common type of cancer and the second leading cause of cancer death in the world. Despite abundant traces of an ancient history, the comprehension of its pathogenic mechanisms is rather recent and continuously updated.

Methods: We investigated about how the ancient civilizations tried to understand the exactly physiopathology of gastric cancer, from the time when they could not examine deeply the histological and pathophysiologic aspects of the disease, but they just based their knowledge on a visual analysis of the signs and consequences of such disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12020264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072612PMC
January 2020

Duodenal Ulceration in a Child with Coeliac Disease.

Diagnostics (Basel) 2020 Jan 9;10(1). Epub 2020 Jan 9.

Filatov Clinical Institute of Child Health, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.

Coeliac disease (CD) is a gluten-dependent inflammatory disease of the small bowel that affects up to 1% of the global population. Herein, the presence of ulcers, erosions, or strictures in the duodenum for non-advanced cases of CD is a rarity. Case report: We present a clinical case of a 17-year-old girl, who from the age of 9, had suffered from erosive (HP)-associated gastritis and erosive duodenitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics10010031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168337PMC
January 2020

Floating Drug Delivery Systems: An Emerging Trend for the Treatment of Peptic Ulcer.

Curr Drug Deliv 2019 ;16(10):874-886

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (MP), India.

Floating drug delivery system (FDDS) is the main approach to prolonging the gastric residence time in the stomach in which the bilayer floating tablet has the main role. It is more suitable for the treatment of local infections such as peptic ulcer, gastritis, Zollinger-Ellision syndrome, indigestion, and other local infections related to the gastrointestinal tract and also used for systemic applications. FDDS provides protection for those drugs which are acid labile and have a short half-life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1567201816666191018163519DOI Listing

Isolation and antimicrobial susceptibility testing of Helicobacter pylori strains from gastric biopsies from Pakistani patients.

Pak J Pharm Sci 2019 Sep;32(5(Supplementary)):2279-2285

Institute of Food and Nutritional Sciences, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.

Helicobacter pylori is the etiological agent of gastritis and peptic ulcer. This importance had proposed antibiotics as a principle treatment of gastrointestinal pathologies. The focus of this research was to investigate the occurrence of H. Read More

View Article

Download full-text PDF

Source
September 2019
0.950 Impact Factor

Predictors of iron-deficiency anemia in primary care older adults: a real-world European multi-country longitudinal study.

Aging Clin Exp Res 2020 Jan 1. Epub 2020 Jan 1.

Italian College of General Practitioners and Primary Care, Health Search, Via Del Sansovino 179, 50141, Florence, Italy.

Background: Iron deficiency is a major cause of anemia in older people. Increasing the knowledge on the predictors of iron-deficiency anemia (IDA) may facilitate its timely diagnosis.

Aim: To investigate the predictors of IDA in older people in four European countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40520-019-01454-6DOI Listing
January 2020

Unique constellations of five polymorphic sites of Helicobacter pylori vacA and cagA status associated with risk of gastric cancer.

Infect Genet Evol 2020 04 28;79:104167. Epub 2019 Dec 28.

Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil 56199-11367, Iran.

Helicobacter pylori possesses virulence genes that are involved in the pathogenesis of the bacterium. There are little data regarding all constellations of five polymorphic sites of H. pylori vacA and cagA status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.104167DOI Listing

The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in -Positive Patients.

Biomed Res Int 2019 9;2019:1450536. Epub 2019 Dec 9.

Department of Family Medicine, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

Background And Aim: As a worldwide infectious bacterium, leads to stomach pathologies such as gastritis, peptic ulcer, gastric cancer, MALToma, and various extragastric manifestations. In our study, we aimed to investigate the association between serum vitamin B12 level and cytotoxin-associated gene-A (CagA) seropositivity, which is one of the virulence factors of ().

Method: This study has been conducted on 289 patients who have met the inclusion criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1450536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925818PMC

Primary hypertrophic osteoarthropathy related gastrointestinal complication has distinctive clinical and pathological characteristics: two cases report and review of the literature.

Orphanet J Rare Dis 2019 12 26;14(1):297. Epub 2019 Dec 26.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Primary hypertrophic osteoarthropathy (PHO) is a rare disease related to HPGD and SLCO2A1 gene mutation. Gastrointestinal involvement of PHO is even rarer with unknown pathogenesis. Clinical features of GI complication in PHO mimics other auto-immune based bowel entities, such as inflammatory bowel diseases and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13023-019-1264-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933916PMC
December 2019

Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy.

Korean J Intern Med 2020 May 12;35(3):574-581. Epub 2019 Dec 12.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.

Background/aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli sprout extract sulforaphane supplementation could increase the H. pylori eradication rate and/or reduce antibiotic-associated adverse events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3904/kjim.2019.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214376PMC

[Gastric neuroendocrine tumors].

Khirurgiia (Mosk) 2019 (12):111-120

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia PA, USA.

Gastrointestinal neuroendocrine tumors are rare neoplasms. Currently, incidence of gastric neuroendocrine tumors (gNETs) is being significantly increased. There are 3 groups of gNETs: types I, II and III. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/hirurgia2019121111DOI Listing
December 2019

Significance of TC9 and TH9 in Helicobacter pylori-induced gastritis.

Helicobacter 2020 Feb 5;25(1):e12672. Epub 2019 Dec 5.

Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: H pylori plays a critical role in the development of stomach cancer, especially in people affected by the bacteria at an early stage of life. Th9 cells and IL-9 play major roles in immune responses against various infections. IL-9 is influential in chronic or acute inflammation of the mucosa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hel.12672DOI Listing
February 2020
5 Reads

Is Roux-en-Y or Billroth-II reconstruction the preferred choice for gastric cancer patients undergoing distal gastrectomy when Billroth I reconstruction is not applicable? A meta-analysis.

Medicine (Baltimore) 2019 Nov;98(48):e17093

Department of Surgical Oncology, Baoji Central Hospital.

Background: Although Billroth II and Roux-en-Y procedures are the two most commonly performed types of reconstruction techniques following distal stomach resection, there is yet no consensus on which reconstruction is the best choice. This meta-analysis aims to compare the perioperative safety and long-term complications of Billroth-II and Roux-en-Y reconstruction.

Method: We searched the databases of the PubMed, the Cochrane Library, Web of Science, EMBASE, and the Chinese Biomedicine Database from January 2000 to January 2018 and included studies that compared Roux-en-Y with Billroth-II reconstruction after distal gastrectomy for gastric cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000017093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890286PMC
November 2019

Value of CIM, CLO Test and Multiplex PCR for the Diagnosis of Helicobacter Pylori Infection Status in Patients with Gastritis and Gastric Ulcer.

Asian Pac J Cancer Prev 2019 Nov 1;20(11):3497-3503. Epub 2019 Nov 1.

Department of Surgery, Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.

Objective: To assess the value of Current Infection Marker (CIM) test, Campylobacter-Like Organism (CLO) test, and the multiplex polymerase chain reaction test (PCR) for the diagnosis of Helicobacter pylori (H. pylori) infection in a Vietnamese population.

Methods: Targeted suitable patients were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31557/APJCP.2019.20.11.3497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062995PMC
November 2019

Virulence Factors Exploiting Gastric Colonization and its Pathogenicity.

Toxins (Basel) 2019 11 19;11(11). Epub 2019 Nov 19.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.

colonizes the gastric epithelial cells of at least half of the world's population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer. To successfully colonize and establish a persistent infection, the bacteria must overcome harsh gastric conditions. has a well-developed mechanism by which it can survive in a very acidic niche. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11110677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891454PMC
November 2019
2.480 Impact Factor

Search for Potential Inducible Nitric Oxide Synthase Inhibitors with Favorable ADMET Profiles for the Therapy of Helicobacter pylori Infections.

Curr Top Med Chem 2019 ;19(30):2795-2804

Graduate Program in Pharmaceutical Sciences, Health Sciences Center - CCS, Federal University of Espirito Santo - UFES, Marechal Campos Av., 1468, Vitoria 29043-900, ES, Brazil.

Background: Helicobacter pylori is a gram-negative bacterium related to chronic gastritis, peptic ulcer and gastric carcinoma. During its infection process, promotes excessive inflammatory response, increasing the release of reactive species and inducing the production of pro-inflammatory mediators. Inducible Nitric Oxide Synthase (iNOS) plays a crucial role in the gastric carcinogenesis process and a key mediator of inflammation and host defense systems, which is expressed in macrophages induced by inflammatory stimuli. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568026619666191112105650DOI Listing
February 2020