8,358 results match your criteria Gastritis and Peptic Ulcer Disease


Clinical characteristics and risk factors of patients with flupirtine-induced liver cirrhosis complicated with upper gastrointestinal bleeding.

Am J Transl Res 2021 15;13(5):5582-5588. Epub 2021 May 15.

Department of Gastroenterology, Qinghai University Affiliated Hospital Qinghai, China.

Objective: To investigate clinical characteristics and risk factors of patients with Flupirtine-induced liver cirrhosis complicated with upper gastrointestinal bleeding.

Methods: A total of 116 patients with liver cirrhosis admitted to our hospital from July 2018 to July 2019 were selected and divided into bleeding group (liver cirrhosis complicated with upper gastrointestinal bleeding, n = 71) and non-bleeding group (liver cirrhosis, n = 45). The clinical data of patients in the two groups were collected, including general data, liver function, urinalysis, coagulation function and imaging data. Read More

View Article and Full-Text PDF

Acute Peptic Ulcer Disease Caused by Non-Helicobacter pylori-Helicobacter.

Cureus 2021 May 12;13(5):e14993. Epub 2021 May 12.

Gastroenterology, University of Connecticut Health, Farmington, USA.

Human infection by Non--Helicobacter is rare and most commonly transmitted through direct contact with animals. The clinical presentation in most cases is chronic epigastric abdominal pain and it usually leads to chronic gastritis. We present an uncommon case of a patient with acute onset abdominal pain secondary to acute peptic ulcer disease caused by who underwent successful treatment. Read More

View Article and Full-Text PDF

Prevalence of infection and the incidence of the associated malignant and peptic ulcer disease (PUD) at Nelson Mandela Academic Hospital: a retrospective analysis.

Authors:
Stephen Z Molaoa

J Drug Assess 2021 Feb 8;10(1):57-61. Epub 2021 Feb 8.

Walter Sisulu University and Nelson Mandela Academic Hospital, Department of Surgery, and Department of Health Studies, University of South Africa, Mthatha, South Africa.

Background: infection is associated with both benign and malignant gastrointestinal diseases. However, no studies have been conducted locally describing the prevalence of and its associated GIT diseases. The objectives of this study are to determine the prevalence of , and the incidence of PUD and gastric malignancies among patients who are infected with or who have the stigmata of previous exposure to . Read More

View Article and Full-Text PDF
February 2021

The clinical and endoscopic aspects of peptic ulcers secondary to the use of nonsteroidal anti-inflammatory drugs of various origins.

Pan Afr Med J 2021 15;38:170. Epub 2021 Feb 15.

Anesthesia-Reanimation Service, Hospital of Sikasso, Sikasso, Mali.

Introduction: currently, the non-steroid anti-inflammatory drugs constitute a veritable object of auto medication throughout the world. The goal of this study was to evaluate the endoscopic and clinical aspects of gastro-duodenal ulcer secondary to taking of non-steroid anti-inflammatory of various sources.

Methods: this was a cross-sectional study which was conducted between July 2016 and December 2017. Read More

View Article and Full-Text PDF

Prevalence of tumor necrosis factor alpha inducing protein () gene of and its association with upper gastrointestinal diseases in India.

3 Biotech 2021 May 30;11(5):246. Epub 2021 Apr 30.

Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, UP India.

() is known to cause several gastroduodenal diseases including chronic Gastritis, Peptic Ulcer disease and Gastric Cancer. Virulent genes of like , are known to be responsible for the disease pathogenesis. However, these virulence genes are not always found to be associated with disease outcome in all populations around the world. Read More

View Article and Full-Text PDF

Construction of metronidazole capped in gold nanoparticles against : antimicrobial activity improvement.

Folia Med (Plovdiv) 2021 Apr;63(2):197-202

Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Helicobacter pylori is considered a major agent causing gastritis and peptic ulcer disease. Unfortunately, the occurrence of increasing drug resistance to this bacterium would result in some difficulties in its treatment. Therefore, the application of nanotechnology has been suggested to resolve such problems. Read More

View Article and Full-Text PDF

Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions.

Dose Response 2021 Jan-Mar;19(1):15593258211001259. Epub 2021 Mar 30.

Faculty of Pharmacy, Department of Pharmaceutics, King Abdulaziz University, Jeddah, Saudi Arabia.

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. Alpha-lipoic acid (ALA), a natural potent antioxidant, has been known as a gastroprotective drug yet its low bioavailability may restrict its therapeutic efficacy. This study aimed to formulate and optimize ALA using a self-nanoemulsifying drug delivery system (SNEDDS) with a size of nano-range, enhancing its absorption and augmenting its gastric ulcer protection efficacy. Read More

View Article and Full-Text PDF

Inhibition of low-density lipoprotein uptake by Helicobacter pylori virulence factor CagA.

Biochem Biophys Res Commun 2021 Jun 10;556:192-198. Epub 2021 Apr 10.

Department of Anatomy, Faculty of Medicine, Oita University, Yufu, Oita, 879-5593, Japan. Electronic address:

Helicobacter pylori (H. pylori) infection mainly causes gastroduodenal diseases, including chronic gastritis, peptic ulcer disease and gastric cancer. In recent years, several studies have demonstrated that infection with H. Read More

View Article and Full-Text PDF

CagE, cagA and cagA 3' region polymorphism of Helicobacter pylori and their association with the intra-gastric diseases in Moroccan population.

Diagn Microbiol Infect Dis 2021 Jul 13;100(3):115372. Epub 2021 Mar 13.

Laboratoire de Pathologie Humaine Biomédecine et Environnement, Equipe micro-organismes génomique et facteurs oncogènes, Faculté de médecine et de Pharmacie de Fès (FMPF), Université Sidi Mohammed Ben Abdellah (USMBA), Fès, Maroc.; Laboratoire de microbiologie et de Biologie Moléculaire, FMPF, USMBA. Electronic address:

Helicobacter pylori infection is the most important etiological factor in gastroduodenal diseases development. Its evolution is influenced by several factors, including bacterial virulence genes such as cagA and cagE. This work aimed to evaluate the predictive value of cagE alone and in combination with cagA and CagA-EPIYA-C motifs number as a marker of the infection evolution. Read More

View Article and Full-Text PDF

Impact of Prior Digestive System Disease on In-Hospital Gastrointestinal Bleeding in Patients with Acute Myocardial Infarction.

Risk Manag Healthc Policy 2021 22;14:1233-1239. Epub 2021 Mar 22.

Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China.

Objective: Patients presenting with acute myocardial infarction (AMI) with prior digestive system disease are more likely to suffer from gastrointestinal (GI) bleeding than those without these diseases. However, few articles reported how the different conditions of the digestive tract produced different risks of GI bleeding.

Methods: A single-center study on 7464 patients admitted for AMI from December 2010 to June 2019 in the Beijing Chaoyang Heart Center was retrospectively examined. Read More

View Article and Full-Text PDF

Lessons learned from upper gastrointestinal endoscopy in asymptomatic Chinese.

Helicobacter 2021 Jun 29;26(3):e12803. Epub 2021 Mar 29.

Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: The Helicobacter pylori (H. pylori) infection-related diseases, peptic ulcer, and gastric cancer are frequently asymptomatic until the onset of complications. This study aimed to investigate the prevalence of H. Read More

View Article and Full-Text PDF

A Mouse Model of Helicobacter pylori Infection.

Methods Mol Biol 2021 ;2283:131-151

Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.

Infection with Helicobacter pylori (H. pylori) is of great distress because of its vital role in the pathogenesis of chronic gastritis, peptic ulcers, and in the multi-step carcinogenic process of gastric cancer. The increasing antibiotic resistance pattern of H. Read More

View Article and Full-Text PDF

An Overview of Helicobacter pylori Infection.

Methods Mol Biol 2021 ;2283:1-14

Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

Helicobacter pylori (H. pylori) represents one of the most widespread bacterial infections globally. Infection causes chronic gastritis and increases the risk of peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. Read More

View Article and Full-Text PDF

Cost-Effectiveness of Empirical Bismuth-Based Quadruple Therapy and Tailored Therapy After Clarithromycin Resistance Tests for Helicobacter pylori Eradication.

Dig Dis Sci 2021 Mar 23. Epub 2021 Mar 23.

Department of Gastroenterology, Kyung Hee University College of Medicine, 23 Kyung Hee Dae-ro, Dongdaemun-gu, Seoul, 02447, Korea.

Background: The eradication rate of clarithromycin-based standard triple therapy (STT) for Helicobacter pylori infection has decreased due to clarithromycin resistance (CR). We evaluated the cost-effectiveness of tailored therapy according to CR test results, and compared the results of STT with those of empirical bismuth quadruple therapy (BQT).

Methods: The prospectively collected data of 490 H. Read More

View Article and Full-Text PDF

[Rebamipide: evidence base for use in gastroenterology].

Ter Arkh 2020 Dec 15;92(12):97-104. Epub 2020 Dec 15.

Yevdokimov Moscow State University of Medicine and Dentistry.

Rebamipide is a cytoprotective drug that has been used in practical gastroenterology for 30 years. This article summarizes the main results of the most relevant clinical studies of rebamipide in diseases of various parts of the gastrointestinal tract, including the esophagus, stomach, small and large intestine. Read More

View Article and Full-Text PDF
December 2020

Cytolethal Distending Toxin C Exploits Lipid Rafts to Mitigate -Induced Pathogenesis.

Front Cell Dev Biol 2020 23;8:617419. Epub 2021 Feb 23.

Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.

infection is associated with several gastrointestinal diseases, including gastritis, peptic ulcer, and gastrointestinal adenocarcinoma. Two major cytotoxins, vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), interact closely with lipid rafts, contributing to -associated disease progression. The cytolethal distending toxin consists of three subunits: CdtA, CdtB, and CdtC. Read More

View Article and Full-Text PDF
February 2021

Gastric Perforation Secondary to Fungal Gastritis in an Immuno-Competent Adult.

Cureus 2021 Feb 5;13(2):e13156. Epub 2021 Feb 5.

Pathology, National Institute of Pathology, New Delhi, IND.

Gastrointestinal (GI) tract perforation is a surgical emergency. The epidemiology and etiology of perforation vary considerably across geography. Lower GI tract perforations in the elderly predominate in the West compared to upper GI perforations in the younger population in the tropics. Read More

View Article and Full-Text PDF
February 2021

[A case of gastric perforation that occurred during the incubation period for infectious mononucleosis in an adolescent patient].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(3):245-250

Department of Surgery, Shizuoka City Shimizu Hospital.

A 17-year-old young man visited our hospital because of severe upper abdominal pain and was diagnosed with acute peritonitis caused by gastrointestinal perforation. Emergent surgical treatment was performed, and the perforated lesion of the stomach was repaired. He recovered and was discharged without any complication at 14 days postoperatively. Read More

View Article and Full-Text PDF

Re-bleed and Mortality Amongst Patients Following Initial Endoscopy for Upper Gastrointestinal Bleeding: A Single-Center Nigeria Study.

Cureus 2021 Jan 27;13(1):e12939. Epub 2021 Jan 27.

Digestive Disease Unit, Oak Endoscopy Centre, Port Harcourt, NGA.

Background and aim Clinical and endoscopic parameters are predictive of patient outcome following acute upper gastrointestinal bleeding. The study aimed to investigate factors related to re-bleed and mortality following initial endoscopy among Nigerian patients with recent upper gastrointestinal bleeding (UGIB). Methods This is a cohort study of patients undergoing endoscopy for recent-onset UGIB at a referral endoscopy facility in Port Harcourt, Rivers State, Nigeria, from April 2014 to November 2020. Read More

View Article and Full-Text PDF
January 2021

[Helicobacter pylori: When to look for an infection and treat it in adults?]

Authors:
J-D de Korwin

Rev Med Interne 2021 Feb 26. Epub 2021 Feb 26.

Université de Lorraine, CHRU-Nancy, département de médecine interne et immunologie clinique-BPC, rue du Morvan, 54511 Vandœuvre-Lès-Nancy cedex, France. Electronic address:

Helicobacter pylori infection is acquired during childhood mainly within the family. It causes active chronic gastritis associated with the development of many digestive and extra digestive diseases. Its expression results from interactions between the bacteria, the host and environmental factors modulating the evolution of gastritis and acid secretion. Read More

View Article and Full-Text PDF
February 2021

: Commensal, symbiont or pathogen?

World J Gastroenterol 2021 Feb;27(7):545-560

Department of Propaedeutic of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.

This review considers the data on () which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis, peptic ulcer disease, and gastric cancer, as well as methods for its eradication. However, in recent years, there have been more and more studies which have suggested that has a beneficial, or potentially positive, effect on the human body. Read More

View Article and Full-Text PDF
February 2021

Increased Risk of Severe Gastric Symptoms by Virulence Factors , , , and in Infection.

J Microbiol Biotechnol 2021 Mar;31(3):368-379

Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea.

Two virulence factors of , and , have been known to play a role in the development of severe gastric symptoms. However, they are not always associated with peptic ulcer or gastric cancer. To predict the disease outcome more accurately, it is necessary to understand the risk of severe symptoms linked to other virulence factors. Read More

View Article and Full-Text PDF

Epigallocatechin Gallate with Potent Anti- Activity Binds Efficiently to Its Histone-like DNA Binding Protein.

ACS Omega 2021 Feb 1;6(5):3548-3570. Epub 2021 Feb 1.

Centre of Biomedical Research (CBMR), SGPGIMS Campus, Raibareli Road, Lucknow 226014, Uttar Pradesh, India.

()-a human gastric pathogen-forms a major risk factor for the development of various gastric pathologies such as chronic inflammatory gastritis, peptic ulcer, lymphomas of mucosa-associated lymphoid tissues, and gastric carcinoma. The complete eradication of infection is the primary objective of treating any -associated gastric condition. However, declining eradication efficiencies, off-target effects, and patient noncompliance to prolong and broad-spectrum antibiotic treatments has spurred the clinical interest to search for alternative effective and safer therapeutic options. Read More

View Article and Full-Text PDF
February 2021

Prevalence and Clinical Manifestations of Helicobacter Pylori with Reference to Histopathological Diagnosis.

Kathmandu Univ Med J (KUMJ) 2020 Jan.-Mar;18(69):64-67

Department of Pathology, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.

Background Helicobacter pylori infection is on a steep decline in most of the developed countries; however, in developing countries like Nepal such steep decline is not seen. This may be due to failure of treatment regimens and emergence of drug resistance. Our previous study done in 2004/2005 showed 38% prevalence of Helicobacter pylori. Read More

View Article and Full-Text PDF
February 2021

13C urea breath test to identify Helicobacter pylori Infection in patients with upper gastrointestinal bleeding admitted to the Emergency Department.

Eur Rev Med Pharmacol Sci 2021 01;25(2):804-811

Emergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Objective: Upper gastrointestinal bleeding (UGIB) is a cause of Emergency Department (ED) visits. Peptic ulcer secondary to H. pylori (HP) infection and/or to the use of NSAIDs is the most frequent cause. Read More

View Article and Full-Text PDF
January 2021

and infection in a colony of research macaques: characterization and clinical correlates.

J Med Microbiol 2021 Mar 20;70(3). Epub 2021 Jan 20.

The Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16-825, Cambridge, MA, USA.

( type 1) commonly infects nonhuman primates but its clinical importance is in question. To characterize infection in a colony of rhesus macaques () used in cognitive neuroscience research. Inquiries into the nature of in nonhuman primates are required to further define the organism's virulence and the experimental animal's gastric microbiome. Read More

View Article and Full-Text PDF

Diagnostic Delay in Patients with Eosinophilic Gastritis and/or Duodenitis: A Population-Based Study.

J Allergy Clin Immunol Pract 2021 05 10;9(5):2050-2059.e20. Epub 2021 Jan 10.

Allakos Inc., Redwood City, Calif.

Background: Eosinophilic gastritis and/or eosinophilic duodenitis (EG/EoD) is characterized by persistent symptoms and elevated eosinophils in the gastrointestinal tract. Limited disease awareness and lack of diagnostic guidelines suggest that patients may remain undiagnosed or endure diagnostic delay.

Objective: To characterize the path to diagnosis for patients with EG/EoD in a representative population. Read More

View Article and Full-Text PDF

Gastroduodenal lesions in upper gastrointestinal endoscopy associated with positive histology in cirrhotic patients at Sikasso Hospital: prevalence study.

Pan Afr Med J 2020 5;37:123. Epub 2020 Oct 5.

Service of Gastro-Enterology, Gabriel Touré University Hospital, Bamako, Mali.

The presence of Helicobacter pylori is a major contributor to the genesis of peptic ulcer disease, although its role in the pathogenesis of ulcer in cirrhotic patients is yet to be well established. The aim of this work is to determine the prevalence of gastroduodenal lesions associated with histologically confirmed Helicobacter pylori in cirrhotic patients. This was a retrospective study which was conducted from January 2017 to May 2018 at Sikasso Hospital. Read More

View Article and Full-Text PDF
January 2021

Prevalence, short term outcome and factors associated with survival in patients suffering from upper gastrointestinal bleeding in a resource limited-setting, the case of Mulago hospital in Kampala, Uganda.

Afr Health Sci 2020 Mar;20(1):426-436

Makerere University, school of Health Sciences, Department of Medicine, Gastroenterology unit Mulago Hospital, Kampala, Uganda.

Background: Upper gastrointestinal bleeding (UGIB) is a common cause of admission and death in the gastroenterology service. The prevalence, risk factors and the case fatality rate of UGIB may differ by settings.

Objectives: Our objective was to determine the prevalence of symptoms and the case fatality rate of UGIB among patients at the gastroenterology service of Mulago Hospital in Kampala, Uganda and to describe the clinical and laboratory risk factors associated with the survival of these patients. Read More

View Article and Full-Text PDF

Acute Cholecystitis-like Presentation in an Adult Patient with Gallbladder Agenesis: Case Report and Literature Review.

Case Rep Surg 2020 16;2020:8883239. Epub 2020 Dec 16.

Department of Surgery, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Introduction: Gallbladder agenesis (GA) is a rare congenital malformation, and majority are asymptomatic; however, symptomatic patients present with a clinical picture similar to biliary colic. Work up usually shows contracted gallbladder (GB) on ultrasound (US), and HIDA scan shows nonvisualization. Magnetic resonance cholangiopancreatography (MRCP) can be helpful in the diagnosis; however, the diagnosis without the latter can only be established intraoperatively. Read More

View Article and Full-Text PDF
December 2020