28,672 results match your criteria Gastritis Stress-Induced


HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ALLEVIATES HELICOBACTER PYLORI-INDUCED GASTRO-INTESTINAL INFECTION AND GASTRIC INFLAMMATION IN C57BL/6 MICE: AN IMMUNO-HISTOLOGIC STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):279-282

Alborz University of Medical Sciences, Department of Microbiology, Karaj, Iran.

Background: Helicobacter pylori (H. pylori) has been introduced by since 1983 by Marshal and Warren to play the main role in the pathophysiology of gastritis and gastric ulcers. Almost half of the world population1 is infected by H. Read More

View Article

COMPARISON BETWEEN THE ENDOSCOPIC FINDINGS AND THE HISTOLOGICAL DIAGNOSIS OF ANTRAL GASTRITES.

Arq Gastroenterol 2018 Jul-Sep;55(3):212-215

Universidade Federal de Juiz de Fora (UFJF), Programa de Pós-graduação em Saúde, MG, Brasil.

Background: Gastritis is a very common disorder that is widely distributed worldwide, representing one of the most prevalent pathological entities in Gastroenterology and Digestive Endoscopy.

Objective: This study aims to analyze the correlation between the endoscopic findings and the histological diagnosis of antral gastritis.

Methods: In this study, 92 reports of upper digestive endoscopy were performed between November 2014 and January 2015, including biopsy of the antral gastric mucosa, comparing the endoscopic and histological findings, which were classified according to the Sidney System. Read More

View Article
January 2018
1 Read

Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS).

Methods Mol Biol 2019 ;1901:113-131

Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

The Luciferase Immuno Precipitation System (LIPS) enables the detection of specific serum antibodies by immunoprecipitation of recombinant antigens tagged with a luciferase reporter. Here we describe LIPS assays for the quantification of autoantibodies to the H+, K+-ATPase A (ATP4A) and B (ATP4B) subunits, two serological markers of autoimmune atrophic gastritis and pernicious anemia. In particular, we will describe the expression of luciferase-tagged recombinant ATP4A and ATP4B, their immunoprecipitation with test sera, the recovery and washing of immune-complexes with a protein-A coated resin, and the quantification of autoantibodies by addition of a luciferase substrate and the measurement of the light output from captured luciferase-tagged antigens. Read More

View Article
January 2019

Reduced prevalence of alcoholic gastritis in hospitalized individuals who consume cannabis.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Background: Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co-used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. However, no clinical study has examined the impact of cannabis use on the development of alcoholic gastritis among risky alcohol users. Read More

View Article
December 2018
3 Reads

Role of Inflammasomes in the Development of Gastrointestinal Diseases.

Exp Suppl 2018 ;108:235-268

Sammons Cancer Center, Baylor Simmons Transplant Institute, Dallas, TX, USA.

Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. Read More

View Article
January 2018

MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori.

Mol Med Rep 2018 Dec 5. Epub 2018 Dec 5.

Institute of Cardiovascular Disease, The 960th Hospital of Chinese PLA, Jinan, Shandong 250022, P.R. China.

Helicobacter pylori (H. pylori) infection is the major cause of chronic active gastritis and peptic ulcer disease. Upregulation of IL‑17A is associated with H. Read More

View Article
December 2018

Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.

Pancreas 2019 Jan;48(1):131-134

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.

Our group observed the first case of synchronous gastric neuroendocrine tumor (NET) and duodenal gastrinoma with autoimmune chronic atrophic gastritis (CAG), in the absence of Helicobacter pylori infection. Demographic, clinical, endoscopic, and pathologic data were abstracted from the electronic medical record at Mount Sinai Hospital from 2013 to 2015. The patient's anonymity was carefully protected, and informed consent was obtained for publication of protected health information. Read More

View Article
January 2019

Utility of Diagnostic Studies for Upper Gastrointestinal Symptoms in Children with Orthostatic Intolerance.

J Pediatr 2018 Oct 18. Epub 2018 Oct 18.

Division of Gastroenterology, Children's National Health System, Washington, DC. Electronic address:

Objective: To assess the utility of gastrointestinal (GI) diagnostic studies in the evaluation of patients with orthostatic intolerance.

Study Design: Medical records of 103 consecutive children/young adults with orthostatic intolerance and gastrointestinal symptoms were reviewed. All patients had undergone antroduodenal manometry in conjunction with the tilt table test, autonomic testing, and upper gastrointestinal endoscopy (EGD). Read More

View Article
October 2018

Patient Characteristics from an Emergency Care Center in Rural Western Kenya.

J Emerg Med 2018 Dec 4. Epub 2018 Dec 4.

Division of Global Health and Human Rights, Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts; African Institute for Health Transformation at Sagam Community Hospital, Luanda, Kenya; Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

Background: Emergency care is a neglected area of focus in many low- and middle-income countries. There is a paucity of research on types and frequencies of acute illnesses and injuries in low-resource settings.

Objective: The primary objective of this study was to describe the demographic characteristics and emergency conditions of patients that presented to a new emergency care center (ECC) at Sagam Community Hospital in Luanda, Kenya. Read More

View Article
December 2018

The value of oral contrast ultrasonography in the diagnosis of gastric cancer in elderly patients.

World J Surg Oncol 2018 Dec 7;16(1):233. Epub 2018 Dec 7.

Department of Ultrasonography, Chongming branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 25 South Gate Road, Cheng Qiao Town, Chongming District, Shanghai, 202150, China.

Background: This study aims to investigate the value of oral contrast ultrasonography (OCUS) in the diagnosis of gastric cancer in elderly patients.

Methods: OCUS data obtained from patients ≥ 60 years old were retrospectively analyzed and compared with gastroscopy results.

Results: Among the 12,716 subjects examined by OCUS, 5021 subjects were ≥ 60 years old, which accounted for 39. Read More

View Article
December 2018

Is it Necessary to Send the Sleeve Gastrectomy Specimens to Pathology?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Departments of General Surgery.

Background: Laparoscopic sleeve gastrectomy (LSG) has become more popular among other bariatric procedures. The histopathologic changes in the sleeve gastrectomy specimens have not been widely investigated among the Turkish population.

Objective: The purpose of this study was to delineate these histopathologic findings of the LSG specimens of morbidly obese patients from a single center. Read More

View Article
December 2018
1 Read

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT3 driver mutations.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Murdoch Childrens Research Institute, Australia.

Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gastric pathology. Additionally, IL-11 is required for tumour development in STAT3 dependent murine models of gastric cancer (GC) and, when administered acutely, causes resolving atrophic gastritis. However, it is unclear whether locally elevated IL-11 ligand expression can, in isolation from oncogenic gp130-JAK-STAT pathway mutations, initiate GC pathogenesis. Read More

View Article
December 2018

Pernicious Anemia Presented with Isolated Nominal Dysphasia in Type Ill Polyglandular Failure Female Patient.

Cureus 2018 Sep 14;10(9):e3306. Epub 2018 Sep 14.

Medicine, Xavier University School of Medicine, Oranjestad, ABW.

Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis which predominantly affects the fundus of the stomach. It results in a deficiency of vitamin B12 (cobalamin) as it affects the normal process of absorption in the ileum. The pernicious anemia is characterized by a wide range of hematological and neurological features. Read More

View Article
September 2018

Interleukin 1 Upregulates MicroRNA 135b to Promote Inflammation-associated Gastric Carcinogenesis in Mice.

Gastroenterology 2018 Nov 30. Epub 2018 Nov 30.

Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan; AMED-CREST, AMED, Japan Agency for Medical Research and Development, Tokyo, Japan; WPI Nano-Life Science Institute (Nano-LSI), Kanazawa University, Kanazawa, Japan. Electronic address:

Background & Aims: Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation. Specific changes in gene expression in epithelial cells are difficult to monitor due to the heterogeneity of the tissue. We investigated epithelial cell-specific changes in microRNA expression during gastric inflammation and gastritis-associated carcinogenesis in mice. Read More

View Article
November 2018
7 Reads

Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.

Eur J Cancer Prev 2019 Jan;28(1):58

School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

View Article
January 2019
1 Read

Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test.

Semin Hematol 2018 Oct 7;55(4):256-261. Epub 2018 Aug 7.

Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria; Loha for life, Center of Excellence for Iron Deficiency, Vienna, Austria. Electronic address:

Iron deficiency (ID) workup is a common challenge for gastrointestinal endoscopy. In premenopausal women current guidelines recommend serologic evaluation of coeliac disease only. Here we systematically tested serologic screening for autoimmune gastritis (AIG) in a large cohort of patients with ID. Read More

View Article
October 2018
2 Reads

Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum.

Molecules 2018 Nov 29;23(12). Epub 2018 Nov 29.

School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.

Radix Codonopsis, derived from the roots of (Franch.) Nannf., (Franch. Read More

View Article
November 2018
1 Read

Clinical features of Helicobacter pylori antibody-positive junior high school students in Nagano Prefecture, Japan.

Helicobacter 2018 Dec 4:e12559. Epub 2018 Dec 4.

Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.

Background: Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody-positive junior high school students.

Materials And Methods: We assessed H pylori antibody-positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. Read More

View Article
December 2018

Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults.

Sci Rep 2018 Dec 4;8(1):17616. Epub 2018 Dec 4.

Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel.

Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. Read More

View Article
December 2018
1 Read

Combined Gastric and Colorectal Cancer Screening-A New Strategy.

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.

Background: Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates.

Methods: Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61. Read More

View Article
December 2018
2 Reads

The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the .

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

College of Food Science and Engineering, Jilin University, Changchun 130062, China.

(HE) is a well-known edible and medicinal fungus widely grown in Asian countries. Polysaccharides from the (HEP) are major biological macromolecules. It has been reported that HEP has multiple biological activities, such as antioxidant activity, immunomodulatory effects, anti-inflammatory effect, anti-chronic gastritis activity, and so on. Read More

View Article
November 2018
2 Reads

Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia.

J Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.

Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern marks a critical step in the progression from chronic gastritis to gastric cancer, yet underlying mechanism(s) of inflammation-induced cell death of gastric epithelial cells are poorly understood. We investigated direct effects of a type 1 cytokine associated with autoimmunity and infection, interferon-γ (IFN-γ), on gastric epithelial cells. Read More

View Article
December 2018
2 Reads

Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis.

Case Rep Gastrointest Med 2018 30;2018:7091520. Epub 2018 Oct 30.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

In this report, we described two patients with white globe appearance in autoimmune atrophic gastritis. Endoscopy revealed multiple white substances in the stomach in both cases. Biopsied specimens from the lesions contained dilated glands and showed a decrease in parietal cells. Read More

View Article
October 2018
3 Reads

Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases.

Arab J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

Background And Study Aims: Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of most important gastro-duodenal diseases, such as gastritis, peptic ulcer disease (PUD) and gastric cancer. H. Read More

View Article
November 2018
1 Read

Recent trends in the prevalence of Helicobacter Pylori in symptomatic children: A 12-year retrospective study in a tertiary centre.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. Electronic address:

Objective: Helicobacter pylori infection is common among Asians. However, evidence in the recent years has demonstrated a decrease in the prevalence of H. pylori infection among children and adults worldwide. Read More

View Article
November 2018
1 Read

Nodular gastritis in association with gastric cancer development before and after eradication.

JGH Open 2018 Jun 25;2(3):80-86. Epub 2018 Mar 25.

Second Department of Internal Medicine Wakayama Medical University Wakayama Japan.

Background And Aim: Nodular gastritis is caused by infection and is associated with the development of diffuse-type gastric cancer. This study examined the clinical characteristics of patients with nodular gastritis, including cancer incidence before and after H. pylori eradication. Read More

View Article
June 2018
2 Reads

Roles of Cholesteryl-α-Glucoside Transferase and Cholesteryl Glucosides in Maintenance of Helicobacter pylori Morphology, Cell Wall Integrity, and Resistance to Antibiotics.

MBio 2018 Nov 27;9(6). Epub 2018 Nov 27.

Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India

Infection of the human stomach caused by is very common, as the pathogen colonizes more than half of the world's population. It is associated with varied outcomes of infection, such as peptic ulcer disease, gastric ulcers, and mucosa-associated lymphoid tissue lymphoma, and is generally considered a risk factor for the development of gastric adenocarcinoma. Cholesteryl glucosides (CGs) constitute a vital component of the cell wall of and contribute to its pathogenicity and virulence. Read More

View Article
November 2018
1 Read

Emergency room visits and admission rates of children with neuromuscular disorders: A 10-year experience in a medical center in Taiwan.

Pediatr Neonatol 2018 Oct 2. Epub 2018 Oct 2.

Division of Pediatric Emergency, Department of Emergency, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Ph.D. Program in Translational Medicine, Graduate Institute of Clinical Medicine, 18 Kaohsiung Medical University and Academia Sinica, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background: No previous studies have explored emergency medical care for children with chronic neuromuscular disorders (NMDs). We aimed to determine the major reasons for the emergency room (ER) readmission of pediatric patients with NMDs and suggest changes to the care plan to decrease readmissions.

Methods: Children with chronic NMDs (aged <18 years) who visited a medical center-based ER between January 2005 and January 2015 were included. Read More

View Article
October 2018
1 Read
0.880 Impact Factor

Secreted Mucins on the Ocular Surface.

Authors:
Yuichi Hori

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES151-DES156

Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan.

Mucins, which play important roles on the ocular surface in wettability, lubrication, and barrier function, are classified into two categories: secreted mucins and membrane-associated mucins. The most important secreted mucin on the ocular surface is MUC5AC, which is secreted by the conjunctival goblet cells. In the human conjunctiva, goblet cells are present in higher concentrations in the fornix, inferior nasal bulbar, and the lid wiper on the lid margin. Read More

View Article
November 2018
4 Reads

Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade.

Protein Cell 2018 Nov 26. Epub 2018 Nov 26.

MOE Key Laboratory of Bioinformatics and TCM-X center/Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, 100084, China.

The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Read More

View Article
November 2018
8 Reads

Baicalin, Baicalein, and Lactobacillus Rhamnosus JB3 Alleviated Helicobacter pylori Infections in Vitro and in Vivo.

J Food Sci 2018 Dec 23;83(12):3118-3125. Epub 2018 Nov 23.

Dept. of Biological Science and Technology, China Medical Univ., Taichung, 40402, Taiwan.

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The flavonoid compounds baicalin and baicalein found in many medicinal plants exhibit an anti-inflammatory effect. The administration of Lactobacillus strains reducing the risk of H. Read More

View Article
December 2018
8 Reads

Assessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System.

Pathol Oncol Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Pathological Anatomy, School of Medicine, Universidad de La Frontera, Avenida Alemania 0458, Postal Code, 4810296, Temuco, Chile.

Gastric cancer (GC) is the first cancer-related cause of death in Chile; however, no plan for GC early detection has been implemented in this country. The OLGA system characterizes gastritis from stages 0 to IV according to the risk of developing GC based on H. pylori infection, atrophy, metaplasia and GC. Read More

View Article
November 2018
2 Reads

Overview of MDM2 and B-RAF Expression in Gastric Lesions.

Open Access Maced J Med Sci 2018 Oct 10;6(10):1795-1802. Epub 2018 Oct 10.

Department of Hepato-Gastroenterology, Theodor Bilharz Research Institute, Giza, Egypt.

Background: Globally, gastric cancer (GC) it is the fourth most common cancer and the third cause of cancer-related deaths. Overexpression of MDM2 and B-RAF appeared to be increased in malignancy and associated with poor prognosis in several human tumours, but their role in gastric cancer remains controversial.

Aim: We had investigated the immunohistochemical expression of MDM2 and B-RAF in 136 gastric lesions with/without association. Read More

View Article
October 2018
4 Reads

Gastric Cancer Is the Leading Cause of Death in Italian Adult Patients With Common Variable Immunodeficiency.

Front Immunol 2018 5;9:2546. Epub 2018 Nov 5.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

An increased prevalence of malignant lymphoma and of gastric cancer has been observed in large cohorts of patients with common variable immunodeficiency (CVID), the most frequently symptomatic primary immunodeficiency. Surveillance strategies for cancers in CVID should be defined based on epidemiological data. Risks and mortality for cancers among 455 Italian patients with CVID were compared to cancer incidence data from the Italian Cancer Registry database. Read More

View Article
November 2018
3 Reads

Carcinogenic strains selectively dysregulate the gastric proteome, which may be associated with stomach cancer progression.

Mol Cell Proteomics 2018 Nov 19. Epub 2018 Nov 19.

Division of Gastroenterology, Vanderbilt University, United States

is the strongest risk factor for gastric cancer. Initial interactions between and its host originate at the microbial-gastric epithelial cell interface, and contact between and gastric epithelium activates signaling pathways that drive oncogenesis. One microbial constituent that increases gastric cancer risk is the pathogenicity island, which encodes a type IV secretion system that translocates the effector protein, CagA, into host cells. Read More

View Article
November 2018
6 Reads

Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases.

Microbiol Res 2019 Jan 6;218:49-57. Epub 2018 Oct 6.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Helicobacter pylori (H. pylori) is a bacterial pathogen that resides in more than half of the human population and has co-evolved with humans for more than 58,000 years. This bacterium is orally transmitted during childhood and is a key cause of chronic gastritis, peptic ulcers and two malignant cancers including MALT (mucosa-associated lymphoid tissue) lymphoma and adenocarcinoma. Read More

View Article
January 2019
5 Reads

Personalized risk assessment for dynamic transition of gastric neoplasms.

J Biomed Sci 2018 Nov 19;25(1):84. Epub 2018 Nov 19.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model.

Methods: First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, including Helicobacter pylori infection, history of upper gastrointestinal disease, lifestyle, and dietary habits, on the step-by-step transition rates using data from a high-risk population in Matsu Islands, Taiwan. Second, we incorporated information on the gastric cancer carcinogenesis affected by genomic risk factors (including inherited susceptibility and irreversible genomic changes) based on literature to generate a genetic and epigenetic risk assessment model by using a simulated cohort identical to the Matsu population. Read More

View Article
November 2018
5 Reads

Consortium for Eosinophilic Researchers (CEGIR): Advancing the Field of Eosinophilic GI Disorders Through Collaboration.

Gastroenterology 2018 Nov 16. Epub 2018 Nov 16.

Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine/Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

View Article
November 2018
2 Reads

Acute gastritis caused by concurrent infection with Epstein-Barr virus and cytomegalovirus in an immunocompetent adult.

Clin J Gastroenterol 2018 Nov 16. Epub 2018 Nov 16.

Department of Diagnostic Pathology, Anjo Kosei Hospital, 28 Higashi-hirokute, Anjo-cho, Anjo, Aichi, 446-8602, Japan.

Herein, we describe an extremely rare case of gastritis due to concurrent infection with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) occurring in an immunocompetent adult. The patient was a 35-year-old man who presented with slight fever, nausea, anorexia, weight loss for 3 weeks, mild transaminitis, and leukocytosis with atypical lymphocytes in peripheral blood. The clinical presentation and elevated IgM titers to both EBV-VCA and CMV strongly suggested infectious mononucleosis syndrome caused by co-infection with EBV and CMV. Read More

View Article
November 2018
8 Reads

Evaluation of gastric microbiome and metagenomic function in patients with intestinal metaplasia using 16S rRNA gene sequencing.

Helicobacter 2018 Nov 15:e12547. Epub 2018 Nov 15.

Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.

Background: Despite recent advances in studies on the gastric microbiome, the role of the non-Helicobacter pylori gastric microbiome in gastric carcinogenesis remains unclear. We evaluated the characteristics of the gastric microbiome and metagenomic functions in patients with IM.

Methods: Participants were classified into six groups according to disease status (chronic superficial gastritis [CSG], intestinal metaplasia [IM], and cancer) and H. Read More

View Article
November 2018
1 Read

Chronic gastritis classifications.

Tunis Med 2018 Jul;96(7):405-410

Chronic gastritis are inflammatory diseases of the gastric mucosa whose diagnosis depends on  pathological examination. They are frequent and cover a significant part of the daily activity of pathologists. Their origin is often infectious, particularly by Helicobacter Pylori. Read More

View Article
July 2018
1 Read

Pneumatosis intestinalis a trap for the unwary: Case series and literature review.

Int J Surg Case Rep 2018 Nov 2;53:214-217. Epub 2018 Nov 2.

Royal Alexandra Hospital, Corsebar Rd, Paisely, PA2 9PN, Scotland, UK. Electronic address:

Introduction: Pneumatosis Intestinalis (PI) can present with a broad range of presentations from chronic and non-specific to acute and life threatening. It is paradoxically one of the few conditions where a pneumoperitoneum found in the diagnostic workup is not necessarily an indication for laparotomy.

Presentation Of Cases: The first case is of a 75 year old gentlemen who attended the emergency department after several weeks of worsening abdominal pain and weight loss. Read More

View Article
November 2018
4 Reads

Development and validation of quality of life instruments for chronic diseases-Chronic gastritis version 2 (QLICD-CG V2.0).

PLoS One 2018 14;13(11):e0206280. Epub 2018 Nov 14.

School of Public Health, Kunming Medical University, Kunming, CHINA.

Quality of life is an important outcome indicator to evaluate whether treatment is successful or not. Chronic gastritis leads to ongoing deterioration of subjectively perceived quality of life. There are several generic measures, but they are not developed particularly to assess chronic gastritis problems. Read More

View Article
November 2018
3 Reads

Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence.

PLoS One 2018 14;13(11):e0205644. Epub 2018 Nov 14.

Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.

The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. Read More

View Article
November 2018
8 Reads

Systematic analysis of multigene predictors in gastric cancer exploiting gene expression signature.

J Cell Biochem 2018 Nov 13. Epub 2018 Nov 13.

Department of Gastroenterology, Affiliated Hospital of Jining Medical College, Jining, China.

Gastric cancer (GC) is the second most common cause of cancer death worldwide but could be more curable if diagnosed at an earlier stage. At present, the capability to predict the efficaciousness of molecular diagnosis for GC for each patient remains elusive. The purpose of this study was to identify tumor biomarkers through systems analysis of multigene predictors exploiting the available data resource. Read More

View Article
November 2018
1 Read

Comparative study of gastric cancer and chronic gastritis via network analysis.

Gastroenterol Hepatol Bed Bench 2018 ;11(4):343-351

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: In this study the significant differentially expressed genes (DEGs) related to gastric cancer (GC) and chronic gastritis were screened to introduce common and distinctive genes between the two diseases.

Background: Diagnosis of gastric cancer as a mortal disease and chronic gastritis the stomach disorder which can be considered as risk factor of GCs required safe and effective molecular biomarkers.

Methods: Microarray profiles were downloaded from Gene Expression Omnibus (GEO) and analyzed via GEO2R. Read More

View Article
January 2018
6 Reads

Designing a novel ELISA method based on recombinant antigens to increase sensitivity and specificity of whole cell antigen detection.

Gastroenterol Hepatol Bed Bench 2018 ;11(4):333-342

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: In this research, we designed a direct Enzyme Linked Immunoassay method to detect antigens in stool specimens.

Background: infection as the worldwide problem is related to many gastrointestinal disorders such as gastritis, gastric cancer, non-ulcer disease, peptic ulcer disease and duodenal ulcer.

Methods: We produced and purified recombinant and antigens in and extracted their antibodies from a panel of positive sera specimens. Read More

View Article
January 2018
10 Reads

Helicobacter pylori infection in Sjögren's syndrome:Co-incidence or causality?

Curr Rheumatol Rev 2018 Nov 12. Epub 2018 Nov 12.

Joint, bone and connective tissue research center, Golestan University of medical Sciences, Gorgan. Iran.

Background And Aim: Lymphoid cell infiltration and destruction of exocrine glands, specifically lacrimal and salivary glands are characteristics of Sjogren's syndrome (SS). An etiological role has been proposed for Helicobacter pylori (H.Pylori), interacting in the clinical course and complications of SS (including gastric cancer and lymphoma). Read More

View Article
November 2018
6 Reads