10,831 results match your criteria Gastritis Chronic

Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis.

PLoS Pathog 2022 Jun 29;18(6):e1010628. Epub 2022 Jun 29.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

Helicobacter pylori (H. pylori) is a common gastric pathogen that infects approximately half of the world's population. Infection with H. Read More

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Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.

EMBO J 2022 Jun 29:e109996. Epub 2022 Jun 29.

Division of Gastroenterology and Hepatology, Medical Department, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Helicobacter pylori is a pathogen that colonizes the stomach and causes chronic gastritis. Helicobacter pylori can colonize deep inside gastric glands, triggering increased R-spondin 3 (Rspo3) signaling. This causes an expansion of the "gland base module," which consists of self-renewing stem cells and antimicrobial secretory cells and results in gland hyperplasia. Read More

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[Clinical effects of acupoint catgut embedding with quadruple therapy on Hp (+) chronic atro-phic gastritis of spleen and stomach deficiency syndrome].

Zhen Ci Yan Jiu 2022 Jun;47(6):537-43

Department of Spleen and Stomach Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China.

Objective: To evaluate the clinical effects of acupoint catgut embedding combined with quadruple therapy on Helicobacter pylori (Hp)-positive (+) chronic atrophic gastritis (CAG) of spleen and stomach deficiency syndrome and explore the underlying mechanism.

Methods: Hp (+) CAG patients with spleen and stomach deficiency syndrome were randomly divi-ded into a control group (=68) and a treatment group (=71). In addition to the routine quadruple therapy for two weeks, the patients in the control group received oral Weifuchun Tablets (4 tablets once, tid. Read More

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The relationship between helicobacter pylori infection and nodular antral gastritis in pediatric patients.

J Natl Med Assoc 2022 Jun 25. Epub 2022 Jun 25.

Pediatric Infectious Diseases, Selçuk University Medical School, Konya, Turkey.

Background: Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative bacterium that colonizes the gastric mucosa. It is a common infectious agent in children. Read More

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Plasma Exosomal hsa_circ_0015286 as a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer.

Pathol Oncol Res 2022 9;28:1610446. Epub 2022 Jun 9.

Department of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, China.

Circular RNA (circRNA) is stable and abundant in exosomes as a potential biomarker for the diagnosis and prognosis of tumor. In this study, cancer specific exosomal circRNAs were identified through circRNA microarray, and 58 circRNAs were significantly upregulated in cancer cells derived exosomes. Then 60 patients with newly diagnosed gastric cancer (GC), 30 chronic gastritis patients and 30 healthy subjects were enrolled for further clinical validation. Read More

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Network Pharmacology Approach to Investigate the Mechanism of Modified Liu Jun Zi Decoction in the Treatment of Chronic Atrophic Gastritis.

Ming Zhou

Evid Based Complement Alternat Med 2022 17;2022:7536042. Epub 2022 Jun 17.

Nanjing University of Chinese Medicine, School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing 210023, China.

Although modified Liu Jun Zi decoction (MLD) has favorable outcomes for chronic atrophic gastritis (CAG) in clinics, the identification of its active ingredients and the molecular mechanism of pharmacology are still unknown and need to be solved urgently. In the study, we screened 170 active components of MLD based on oral bioavailability ≥30% and drug-likeness ≥0.18 via the TCMSP platform. Read More

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Iron pill-induced gastritis - An unrecognized side of iron-deficiency anemia.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastrenterology, Centro Hospitalar e Universitário de Coimbra, Portugal.

Iron-deficiency anemia is a prevalent condition usually treated with iron supplementation. Iron pill-induced gastritis is an under-recognized, albeit serious potential complication of iron pill ingestion in the upper gastrointestinal tract. This entity must be identified by healthcare providers who prescribe iron. Read More

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Endoscopic Features of Autoimmune Gastritis: Focus on Typical Images and Early Images.

J Clin Med 2022 Jun 19;11(12). Epub 2022 Jun 19.

Department of Digestive Endoscopy, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

Autoimmune gastritis (AIG) is chronic atrophic gastritis caused by an autoimmune mechanism of unknown etiology and presents with various pathological conditions by causing an achlorhydria state through parietal cell damage. The most characteristic endoscopic finding in AIG is advanced corpus-dominant mucosal atrophy. A recent study that examined several cases in Japan revealed the presence of endoscopic features other than corpus-dominant advanced atrophy. Read More

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Differential Expression of Tissular miRNA-155 in Pediatric Gastritis.

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Department of Internal Medicine VII, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street No 38, 540136 Targu Mures, Romania.

Background: MicroRNA molecules, among them the intensely studied miRNA-155 (miR-155), are regarded as potential biomarkers of chronic gastric inflammation and premalignant lesion progression. However, literature data are scarce in terms of pediatric studies and in the evaluation of the predictive role of miRNA in early gastric inflammation. This study aims to assess the differential expression of miR-155 in relation to pediatric gastritis. Read More

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Comment on Skrebinska et al. Who Could Be Blamed in the Case of Discrepant Histology and Serology Results for Detection? 2022, , 133.

Diagnostics (Basel) 2022 Jun 9;12(6). Epub 2022 Jun 9.

Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Street 93, H-1091 Budapest, Hungary.

In their article, Skebrinska and colleagues analysed the potential pitfalls of detecting () by serology, histological (Giemsa) and immunohistochemical (IHC) staining. However, in the Introduction, the authors state: "…IHC is recommended only in individuals with active gastritis without identification by histochemistry". Although this is a widely-held view, it does not seem to hold up in view of the results of the study by Kocsmár et al. Read More

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Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin.

J Microbiol 2022 Jun 22. Epub 2022 Jun 22.

Department of Oral Biochemistry, School of Dentistry, Jeonbuk National University, Jeonju, 54907, Republic of Korea.

Helicobacter pylori infection causes chronic inflammation in the stomach, which is linked to the development of gastric cancer. The anti-inflammatory and anticancer effects of a glycolysis inhibitor 2-deoxyglucose (2DG) and an antidiabetic medication metformin (Met) have gotten attention. Using a Mongolian gerbil animal model, we investigated H. Read More

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Higher proportions of a healthy gastric mucosa in healthy Japanese adults with later birth year: analysis of 41 957 participants.

Jpn J Clin Oncol 2022 Jun 20. Epub 2022 Jun 20.

Department of Public Health Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.

Background: In Japan, most gastric cancers are associated with gastric mucosal atrophy caused by chronic infection with Helicobacter pylori (H. pylori). Recognizing the condition of the gastric mucosa and determining the infection status of H. Read More

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Toll-like receptor 9 promotes initiation of gastric tumorigenesis by augmenting inflammation and cellular proliferation.

Cell Mol Gastroenterol Hepatol 2022 Jun 15. Epub 2022 Jun 15.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia; Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3168, Australia. Electronic address:

Background & Aims: Gastric cancer (GC) is strongly linked with chronic gastritis following Helicobacter pylori (H. pylori) infection. Toll-like receptors (TLRs) are key innate immune pathogenic sensors that mediate chronic inflammatory and oncogenic responses. Read More

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Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori-related diseases.

Fundam Clin Pharmacol 2022 Jun 18. Epub 2022 Jun 18.

Clinical Microbiology Research Centre, Ilam University of Medical Sciences, Ilam, Iran.

Helicobacter pylori (H. pylori) is a microaerophilic gastric pathogen and a major contributor to chronic atrophic gastritis, peptic ulcer, and gastric malignancies. The increasing prevalence of H. Read More

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Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study.

Int J Clin Pharmacol Ther 2022 Jun 17. Epub 2022 Jun 17.

Objectives: Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis. This study aims to assess persistence with sulfasalazine and also frequency and severity of adverse drug reactions (ADRs) encountered with this very well-established disease-modifying anti-rheumatoid drug.

Materials And Methods: This retrospective study was done in 1,114 patients from medicine and rheumatology outpatient departments of six centers across India. Read More

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Elevated carbohydrate antigen 19-9 following Helicobacter suis gastritis and normalisation after eradication: first case report and review of the literature.

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):403-405

Department of Gastroenterology, Catholic University of Louvain (UCLouvain), CHU UCL Namur, Yvoir, Belgium.

Carbohydrate antigen 19-9 (CA 19-9) is a biological marker used to diagnose and monitor the progression of various cancers. Elevated CA 19-9 has also been sporadically observed in Helicobacter pylori infected patients. Similar to H. Read More

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Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review.

Crit Rev Food Sci Nutr 2022 Jun 16:1-66. Epub 2022 Jun 16.

Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok, Thailand.

Age-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various disease conditions. Read More

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Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin Changes (POEMS) Syndrome and Idiopathic Portal Hypertension: A Rare Association.

Cureus 2022 May 11;14(5):e24923. Epub 2022 May 11.

Hematology, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The diagnosis of POEMS syndrome is made with three of the major criteria, two of which must include polyradiculoneuropathy and clonal plasma (PCD), and at least one of the minor criteria. The most frequent liver manifestation is hepatomegaly. Read More

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A deep learning network based on multi-scale and attention for the diagnosis of chronic atrophic gastritis.

Z Gastroenterol 2022 Jun 13. Epub 2022 Jun 13.

Wuhan University, Wuhan City, China.

Background And Study Aim: Chronic atrophic gastritis plays an important role in the process of gastric cancer. Deep learning is gradually introduced in the medical field, and how to better apply a convolutional neural network (CNN) to the diagnosis of chronic atrophic gastritis remains a research hotspot. This study was designed to improve the performance of CNN on diagnosing chronic atrophic gastritis by constructing and evaluating a network structure based on the characteristics of gastroscopic images. Read More

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Pathophysiology and therapeutic management of anemia in gastrointestinal disorders.

Expert Rev Gastroenterol Hepatol 2022 Jun 20:1-13. Epub 2022 Jun 20.

Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, Italy.

Introduction: Anemia is a common complication of gastrointestinal (GI) disorders, with a prevalence up to 60% in celiac disease (CeD) and inflammatory bowel disease (IBD). Iron deficiency anemia (IDA) is the most prevalent form of anemia in these conditions, but chronic inflammation and vitamin B12 deficiency represent other common contributing mechanisms, especially in IBD.

Areas Covered: We discuss the pathogenesis of anemia in various medical GI disorders, the sometime problematic distinction between IDA, anemia of inflammation (AI) and the association of the two, and therapeutic and preventive measures that can be useful for the management of anemia in GI disorders. Read More

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Bayesian comorbidity network and cost analysis for asthma.

IEEE J Biomed Health Inform 2022 Jun 13;PP. Epub 2022 Jun 13.

The evolving disease spectrum poses significant challenges to the asthma management, thus worsening health quality and increased financial burden on patients. However, potential dependency pattern in comorbidity spectrum remains unclear. We built comorbidity networks based on Bayesian networks utilizing 19604 asthma-patient hospitalization data to investigate dependency patterns among asthma comorbidities. Read More

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Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: Results of a prospective study.

Helicobacter 2022 Jun 13:e12910. Epub 2022 Jun 13.

Department of Gastroenterology, Mahmoud Matri Hospital, Ariana, Tunisia.

Helicobacter pylori infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. Gradually, H. pylori gastritis will result in gastric atrophy and intestinal metaplasia. Read More

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Efficacy of Self-Made Decoction for Chronic Atrophic Gastritis and Its Effect on Gastrin and Pepsinogen Expression Levels.

Jianyun Ou Lin Wang

Contrast Media Mol Imaging 2022 1;2022:1092695. Epub 2022 Jun 1.

Department of Integrated Traditional Chinese and Western Medicine, First People's Hospital of Fuyang District, Hangzhou 311400, Zhejiang Province, China.

We aim to investigate the therapeutic effect of self-made decoction based on the differences-in-differences (DID) model for treating chronic atrophic gastritis and its effect on the gastrin and pepsinogen expression. A total of 166 chronic atrophic gastritis patients treated in our hospital from January 2019 to September 2020 were recruited and randomly assigned to a treatment group and a control group ( = 83 per group). In the control group, patients were given conventional western medicine. Read More

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Epstein-Barr Virus is Associated with Gastric Cancer Precursor: Atrophic Gastritis.

Int J Med Sci 2022 21;19(5):924-931. Epub 2022 May 21.

Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong university of Science and Technology, Wuhan 430030 Hubei Province, China.

About 10% of gastric cancer (GC) has been described to be Epstein-Barr virus (EBV) positive. Previous researches have described the association between EBV and GC. However, the association of EBV with atrophic gastritis (AG) is underrecognized. Read More

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Autoimmune polyendocrine syndrome type 1: Clinical manifestations, pathogenetic features, and management approach.

Autoimmun Rev 2022 Jun 9;21(8):103135. Epub 2022 Jun 9.

Semey Medical University, Semey, Kazakhstan; CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan.

Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive hereditary pathology that develops with endocrine and non-endocrine manifestations in childhood. The classic triad of APS-1 includes chronic candidiasis of the skin and mucous membranes, adrenal insufficiency, and hypoparathyroidism. APS-1 is often accompanied by hypogonadism, type 1 diabetes, autoimmune thyroiditis, vitiligo, alopecia, asplenia, pneumonitis, gastritis, pernicious anemia, and intestinal dysfunction, nephritis, and hepatitis. Read More

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Animal Models and Infection.

J Clin Med 2022 May 31;11(11). Epub 2022 May 31.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan.

colonize the gastric mucosa of at least half of the world's population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of -associated complications. Read More

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Efficacy and Safety of Ombitasvir/Paritaprevir/ Ritonavir + Dasabuvir ± Ribavirin Combinations in Patients with Genotype 1 Hepatitis C and Inherited Bleeding Disorders.

Turk J Gastroenterol 2022 05;33(5):414-420

Department of Hematology, İstanbul University-Cerrahpaşa Cerrahpaşa School of Medicine, İstanbul, Turkey.

Background: Hepatitis C is one of the leading causes of death in patients with inherited bleeding disorders. Currently, direct-acting antiviral drugs used for the treatment of hepatitis C have become an effective and a reliable option for people with inherited bleeding disorders. The aim of this study is to report the efficacy and safety of ombitasvir + paritaprevir/ritonavir and dasabuvir combination in the treatment of hepatitis C in patients with inherited bleeding disorders. Read More

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Influences of Helicobacter pylori infection on diversity, heterogeneity, and composition of human gastric microbiomes across stages of gastric cancer development.

Helicobacter 2022 Jun 9:e12899. Epub 2022 Jun 9.

Computational Biology and Medical Ecology Lab, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Background: About a half of the world's population is infected with Helicobacter pylori (H. pylori), but only 1%-3% of them develop gastric cancer. As a primary risk factor for gastric cancer, the relationship between H. Read More

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Detection and quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus-6 in stomach frozen tissue of chronic gastritis and gastric cancer patients.

Microbiol Immunol 2022 Jun 8. Epub 2022 Jun 8.

Research Center for Gastroenterology and Liver Diseases, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Siences, Tehran, Iran.

Human herpes viruses (HHVs) are among the most common infectious agents detected in the gastrointestinal tract that might be involved in oncogenesis and other gastrointestinal disorders. Although the link between the Epstein-Barr virus (EBV) and gastric cancer (GC) has been established, the role of the viruses in various stomach diseases remains unknown. The frequencies and viral copy number of EBV, cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6) among 50 gastric cancer tumors and 105 chronic gastritis tissues were measured by quantitative real-time PCR. Read More

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Risk Factors Analysis and Prediction Model Establishment of Intestinal Metaplasia or Dysplasia in Patients With Chronic Atrophic Gastritis: A Multi-Center Retrospective Study.

Front Med (Lausanne) 2022 18;9:912331. Epub 2022 May 18.

Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.

Objective: To investigate the risk factors and construct a prediction model of chronic atrophic gastritis (CAG) patients with intestinal metaplasia or dysplasia.

Method: The clinical data of 450 patients with CAG who were diagnosed and treated in the Department of Gastroenterology of the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from June 2016 to February 2022 were collected. Single and multiple factors logistic regression analysis were used to explore the risk factors of intestinal metaplasia or dysplasia in patients of training cohort. Read More

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