9,745 results match your criteria Gastritis Chronic


Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
February 2019

Pathologic findings of the removed stomach during sleeve gastrectomy.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL, USA.

Background: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. Read More

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http://dx.doi.org/10.1007/s00464-019-06689-yDOI Listing
February 2019

[Gastric Neuroendocrine Carcinoma(NEC)Treated with CDDP plus CPT-11 Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):65-69

Dept. of Digestive Surgery, Saku Central Hospital Advanced Care Center.

A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Read More

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January 2019
2 Reads

Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats.

Med Sci Monit 2019 Feb 13;25:1177-1186. Epub 2019 Feb 13.

External Liaison Office, Second Affiliated Hospital of Nanjing University of Chinese Medicine (Second Hospital of Jiangsu Province), Nanjing, Jiangsu, China (mainland).

BACKGROUND This study investigated the effect and mechanism of notoginsenoside R1 (NGR1) on chronic atrophic gastritis (CAG) in a rat model. MATERIAL AND METHODS To perform our investigation, a rat model of CAG was established, and then rats were treated with various doses of NGR1. After treatment, hematoxylin-eosin (HE) staining was used for histopathological observation and further scoring. Read More

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http://dx.doi.org/10.12659/MSM.911512DOI Listing
February 2019

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
1 Read

Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs.

BMC Cancer 2019 Feb 8;19(1):129. Epub 2019 Feb 8.

Guangzhou University of Chinese Medicine, No.12 Jichang Road, Guangzhou, 510405, Guangdong Province, China.

Background: Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined as precancrerous lesions of GC remain largely elusive. To investigate serum exosomal miRNAs that are differently expressed in CAG patients and Chronic nonatrophic gastritis (CNAG) may be helpful for its diagnosis and therapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368711PMC
February 2019
2 Reads

Helicobacter pylori infection alters gastric and tongue coating microbial communities.

Helicobacter 2019 Feb 7:e12567. Epub 2019 Feb 7.

The Traditional Chinese Medicine Hospital of Shijiazhuang Affiliated to Hebei University of Chinese Medicine, Shijiazhuang, China.

Objective: Infection with Helicobacter pylori (H pylori), especially cytotoxin-associated gene A-positive (CagA+) strains, has been associated with various gastrointestinal and extragastric diseases. The aim of this study was to characterize H pylori-induced alterations in the gastric and tongue coating microbiota and evaluate their potential impacts on human health.

Design: The gastric mucosa and tongue coating specimens were collected from 80 patients with chronic gastritis, and microbiota profiles were generated by 16S rRNA gene sequencing. Read More

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http://doi.wiley.com/10.1111/hel.12567
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http://dx.doi.org/10.1111/hel.12567DOI Listing
February 2019
2 Reads

Helicobacter pylori infection in children: an overview of diagnostic methods.

Eur J Clin Microbiol Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.

Children differ from adults regarding Helicobacter pylori (H. pylori) infection in many terms. H. Read More

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http://link.springer.com/10.1007/s10096-019-03502-5
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http://dx.doi.org/10.1007/s10096-019-03502-5DOI Listing
February 2019
4 Reads

Case of thrombosis of the portal vein and its branches in a patient seropositive for Borrelia antigens.

Ter Arkh 2018 Nov;90(11):79-89

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.

Borreliosis after sucking ticks is an acute problem in the world. People do not go to doctors after that often, which leads to the development of various complications. Thrombosis of veins of various localization can be one of them. Read More

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http://dx.doi.org/10.26442/terarkh2018901179-89DOI Listing
November 2018
1 Read

Comorbid for gastroduodenal ulcers in the aspect of calcium imbalance and blockers of slow calcium channels in their treatment.

Authors:
L A Fomina

Ter Arkh 2018 Feb;90(2):28-34

Tver State Medical University, Ministry of Health of Russia, Tver, Russia.

Aim: Find out the calcium content of the blood reflecting its balance and functional status the calcium regulatory system when it is comorbid for gastroduodenal ulcers (GDU), developed on the background of chronic erosive gastritis (CEG), chronic erosive duodenitis (CED), arterial hypertension (AH) and osteo-articular pathology with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the impact of his changes on the activity ulzerogennogo process, the state of regional microcirculation and the functions of the stomach. To determine the pathogenetic justification for and effectiveness of blockers of slow calcium channels (BSCaC) in complex treatment.

Materials And Methods: Examined 132 patients with GDU. Read More

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http://dx.doi.org/10.26442/terarkh201890228-34DOI Listing
February 2018
1 Read

A human mode of intestinal type gastric carcinoma.

Authors:
Shaoqing Lai

Med Hypotheses 2019 Feb 14;123:27-29. Epub 2018 Dec 14.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:

Gastric cancer is a malignant tumor originating from the gastric mucosa epithelium. Intestinal type gastric cancer is frequently taken on elderly men, and there are many high incidence areas around the world. Intestinal type gastric cancer often is accompanied by gastric mucosal atrophy, intestinal metaplasia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183121
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http://dx.doi.org/10.1016/j.mehy.2018.12.009DOI Listing
February 2019
6 Reads

NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production.

World J Gastroenterol 2019 Jan;25(3):330-345

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea.

Background: Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343100PMC
January 2019
1 Read

Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.

BMC Gastroenterol 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Background: The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the region for better management of infections caused by such bacteria.

Methods: Four hundred two gastric biopsy specimens were analyzed using histopathological examination and real time-PCR. Read More

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http://dx.doi.org/10.1186/s12876-019-0934-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346553PMC
January 2019
3 Reads

Diagnostic performance of serum pepsinogen assay for the prediction of atrophic gastritis and gastric neoplasms: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14240

Department of Internal Medicine.

Background: Serum pepsinogen assay (sPGA) combining concentration of pepsinogen I (PG I), and the ratio of PG I/II is the noninvasive biomarker for predicting chronic atrophic gastritis (CAG) and neoplasms reflecting mucosal secretory status. Although various cut-off values have been suggested, PG I ≤70 ng/mL and PG I/II ≤3 have been widely accepted. However, previous studies for diagnostic test accuracy presented only pooled outcomes, which cannot discriminate the diagnostic validity of sPGA with cut-off of PG I ≤70 ng/mL and PG I/II ≤3. Read More

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http://dx.doi.org/10.1097/MD.0000000000014240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358409PMC
January 2019
1 Read
5.723 Impact Factor

Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.

BMC Gastroenterol 2019 Jan 21;19(1):14. Epub 2019 Jan 21.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. Read More

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http://dx.doi.org/10.1186/s12876-018-0918-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341657PMC
January 2019
1 Read

Insights into Pediatric Autoimmune Gastritis: Is There a Role for Helicobacter Pylori Infection?

J Pediatr Gastroenterol Nutr 2019 01 17. Epub 2019 Jan 17.

Pediatric Gastroenterology Unit. Centro Materno Infantil do Norte - CMIN. Centro Hospitalar Universitário do Porto. Porto, Portugal.

Objectives: Autoimmune gastritis (AIG) is a chronic inflammatory condition of the gastric mucosa, mainly described in adults presenting with pernicious anemia. It results from antibody-mediated destruction of parietal cells, but the precise initiating event is unknown. The pathogenicity of Helicobacter pylori (H. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002278DOI Listing
January 2019
2 Reads

Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect.

Saudi Pharm J 2019 Jan 11;27(1):145-153. Epub 2018 Sep 11.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.

Samryeongbaekchul-san (SBS) is a traditional herbal formula, which is used for the treatment of dyspepsia, chronic gastritis, and anorexia in Korea. To evaluate the quality of SBS decoction by quantifying its main constituents simultaneously using high-performance liquid chromatography coupled with photodiode array (HPLC-PDA) detection, and secondly to determine the antiadipogenic effect of SBS decoction. The main constituents in a 10-μL injection volume of the decoction were separated on Gemini C and Luna NH columns (both 250 mm × 4. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323196PMC
January 2019

Macrophages activate mesenchymal stem cells to acquire cancer-associated fibroblast-like features resulting in gastric epithelial cell lesions and malignant transformation .

Oncol Lett 2019 Jan 15;17(1):747-756. Epub 2018 Nov 15.

Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.

The majority of premalignant gastric lesions develop in the mucosa that has been modified by chronic inflammation. As components of the gastritis microenvironment, mesenchymal stem cells (MSCs) and macrophages are critically involved in the initiation and development of the chronic gastritis-associated gastric epithelial lesions/malignancy process. However, in this process, the underlying mechanism of macrophages interacting with MSCs, particularly the effect of macrophages on MSCs phenotype and function remains to be elucidated. Read More

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http://dx.doi.org/10.3892/ol.2018.9703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313054PMC
January 2019
1 Read

Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico: An observational study.

Medicine (Baltimore) 2019 Jan;98(3):e14124

Laboratory of Clinical Research, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero.

The chronic inflammation and damage to the gastric epithelium induced by Helicobacter pylori (H. pylori) are the main risk factors for gastric cancer development. Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) induce chronic inflammation and have been found in gastric tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000014124DOI Listing
January 2019
4 Reads

The Diagnostic Tests for Detection of Helicobacter pylori Infection.

Monoclon Antib Immunodiagn Immunother 2019 Jan 16. Epub 2019 Jan 16.

1 Department of Microbiology, Shahr-e-Qods-Branch, Islamic Azad University, Tehran, Iran.

Helicobacter pylori causes one of the most common infections in human populations. The role of this bacterium in chronic gastritis, gastric ulcer, gastric cancer, as well as extra-digestive diseases such as ischemic heart disease and chronic obstructive pulmonary diseases, is well known. Prevention and control of these diseases can occur by early diagnosis and eradication of H. Read More

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https://www.liebertpub.com/doi/10.1089/mab.2018.0032
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http://dx.doi.org/10.1089/mab.2018.0032DOI Listing
January 2019
7 Reads

The lipoprotein HP1454 of Helicobacter pylori regulates T-cell response by shaping T-cell receptor signalling.

Cell Microbiol 2019 Jan 15:e13006. Epub 2019 Jan 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Helicobacter pylori (HP) is a Gram-negative bacterium that chronically infects the stomach of more than 50% of human population and represents a major cause of gastric cancer, gastric lymphoma, gastric autoimmunity, and peptic ulcer. It still remains to be elucidated, which HP virulence factors are important in the development of gastric disorders. Here, we analysed the role of the HP protein HP1454 in the host-pathogen interaction. Read More

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http://dx.doi.org/10.1111/cmi.13006DOI Listing
January 2019
6 Reads
4.915 Impact Factor

Unexplained Portal Gas in a Patient with an Esophageal Ulcer.

Case Rep Gastrointest Med 2018 10;2018:2496193. Epub 2018 Dec 10.

Sinai Hospital, Baltimore, Maryland, USA.

Emphysematous gastritis is the infection of gastric mucosa by gas producing microorganisms. It is a rare infection with less than 100 cases reported in the literature. The association of portal venous gas along with emphysematous gastritis is a rare entity. Read More

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http://dx.doi.org/10.1155/2018/2496193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311260PMC
December 2018
2 Reads

The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, Pisa 56126, Italy. Electronic address:

Graves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.10.001DOI Listing
January 2019
11 Reads

The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Gastroenterology and Center for Autoimmune Liver Diseases, ASST San Gerardo Hospital, Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.

Chronic autoimmune atrophic gastritis (CAAG) is an organ-specific autoimmune disease, which affects the corpus-fundus gastric mucosa. Although it has been described for several years, the real pathophysiological mechanisms, the natural history and the possible neoplastic complications are not completely known. Atrophy of the gastric mucosa is the endpoint of the chronic processes, with the loss of glandular cells and their replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.08.011DOI Listing
January 2019
5 Reads

Association of Helicobacter pylori Infection With Colon Cancer and Adenomatous Polyps.

Iran J Pathol 2018 12;13(3):325-332. Epub 2018 Sep 12.

Dept of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background And Objective: infection is one of the most common chronic bacterial infections in the world, especially in the developing countries. This bacterium is the cause of many diseases such as lymphoma, gastritis, peptic ulcers, and stomach cancer. According to recent reports, infection can potentially increase the risk of colon cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322532PMC
September 2018
1 Read

[Ganglioneuroblastoma in a child with chronic abdominal pain - a case report].

Dev Period Med 2018 ;22(4):364-370

II Katedra i Klinika Pediatrii, Gastroenterologii i Żywienia, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Polska.

Chronic abdominal pain is a very common complaint in the population of children and adolescents. In most cases, the usual cause are functional gastrointestinal disorders. However, in a few percent of children, the reason for persistent chronic stomach pain are organic diseases occurring in the gastrointestinal tract, as well as parenteral diseases, including uro-genital tract abnormalities, inflammation of the lower respiratory tract and cancer processes. Read More

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January 2018
6 Reads

MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia.

Gut 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background And Aims: Gastric intestinal metaplasia (IM) is common in the gastric epithelium of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile acids and following chronic inflammation. But the mechanism underlying how bile acids activate CDX2 in gastric epithelium has not been fully explored. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315318
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http://dx.doi.org/10.1136/gutjnl-2017-315318DOI Listing
January 2019
4 Reads
14.660 Impact Factor

Endoscopic evaluation of immunotherapy-induced gastrointestinal toxicity.

World J Gastrointest Endosc 2018 Dec;10(12):392-399

Digestive Disease Department, General University Hospital of Valencia, Valencia 46014, Spain.

Immunotherapy is any treatment aimed at boosting or enhancing the immune system. It includes a wide range of options, from vaccines to treatment for conditions such as allergy and cancer. In the case of cancer, unlike other available treatments, immunotherapy is not aimed at destroying the tumor cells but at stimulating the patient's immune system so that it attacks the tumor. Read More

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https://www.wjgnet.com/1948-5190/full/v10/i12/392.htm
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http://dx.doi.org/10.4253/wjge.v10.i12.392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323501PMC
December 2018
3 Reads

Characteristics and Predictive Factor of Helicobacter pylori-Associated Functional Dyspepsia in Japanese Patients.

Digestion 2019 Jan 10:1-9. Epub 2019 Jan 10.

Department of Gastroenterology Aichi Medical University, Nagakute, Japan.

Background/aim: Helicobacter pylori (HP) eradication therapy was first recommended as pharmacotherapy for functional dyspepsia (FD). However, the mechanism and effect of eradication on FD symptom improvement have not been fully investigated. This study aimed to investigate the pathology of patients with HP-associated FD, and predictive factors for HP-associated FD. Read More

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https://www.karger.com/Article/FullText/496101
Publisher Site
http://dx.doi.org/10.1159/000496101DOI Listing
January 2019
5 Reads

Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models.

J Ethnopharmacol 2019 Apr 3;233:101-114. Epub 2019 Jan 3.

Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil. Electronic address:

Ethnopharmacological Relevance: Cochlospermum regium (Bixaceae) is a native shrub of Brazil and its xylopodium (infusion/decoction) is being used for the treatment of gastritis, ulcers, arthritis, intestinal infections, gynaecological infections, skin diseases, among others. The aim of the present study was to evaluate the gastroprotective/antiulcer activity and the mechanism of action of hydroethanolic extract of C. regium xylopodium (HECr), using in vitro and in vivo models. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183292
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http://dx.doi.org/10.1016/j.jep.2019.01.002DOI Listing
April 2019
6 Reads

Comparison of body condition score and other minimally invasive biomarkers between dogs with gastric carcinoma and dogs with chronic gastritis.

J Am Vet Med Assoc 2019 Jan;254(2):226-235

OBJECTIVE To identify minimally invasive biomarkers to help differentiate dogs with gastric carcinoma from those with chronic gastritis. DESIGN Prospective study. ANIMALS 15 dogs with gastric carcinoma, 29 dogs with chronic gastritis, and 7 healthy dogs. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.254.2.226
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http://dx.doi.org/10.2460/javma.254.2.226DOI Listing
January 2019
7 Reads

Abnormalities in acute salivary biochemical characteristic responses to gustatory stimulation with citric acid in chronic non-atrophic gastritis.

J Gastroenterol Hepatol 2018 Dec 29. Epub 2018 Dec 29.

Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background And Aim: Salivary characteristics are altered in gastrointestinal diseases and related to oral taste disorder. However, specific salivary biochemical characteristics and their relationships with oral taste disturbances in chronic non-atrophy gastritis (CNAG) remain uncertain.

Methods: Seventy patients with CNAG and 70 subjects in healthy control group (HCG) were enrolled in our study. Read More

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http://dx.doi.org/10.1111/jgh.14587DOI Listing
December 2018
13 Reads

Genotyping and antibiotic resistance properties of strains isolated from human and animal gastric biopsies.

Infect Drug Resist 2018 13;11:2545-2554. Epub 2018 Dec 13.

Biotechnology Research Center, Shahr-e Kord Branch, Islamic Azad University, Shahr-e Kord, Iran.

Purpose: The present study was done to assess the prevalence rate, antibiotic resistance pattern and genotyping status of the strains isolated from human and animal gastric biopsy samples.

Patients And Methods: A total of 1,150 gastric biopsy samples were randomly collected from humans (children and adults) and animals (cows, sheep and goats). All samples were subjected to culture, urease test and histopathologic examination. Read More

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http://dx.doi.org/10.2147/IDR.S187885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296207PMC
December 2018
2 Reads

[Impact of Catgut Embedding Intervention on JAK 2-STAT 3 Signaling in Gastric Mucosa of Chronic Atrophic Gastritis Rats].

Zhen Ci Yan Jiu 2018 Nov;43(11):682-6

Foshan Renhe Hospital of Chinese Medicine, Foshan 528000, Guangdong Province.

Objective: To observe the impact of catgut embedding on histopathological changes and expression of phosphorylated-Janus kinase-2 (p-JAK 2), phosphorylated-signal transducer and activator of transcription 3 (p-STAT 3), Cyclin D 1, Bcl-2, and suppressor of cytokine signaling (SOCS) of the gastric mucosa in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improving CAG.

Methods: Forty-one SD rats were randomly divided into normal (=12), model (=9), natural recovery (=10) and catgut embedding (=10) groups. The CAG model was established by free drinking of N-methyl-N'-nitro-N-nitroso-guanidine (MNNG) solution (100µg/mL) and irregular diet for 24 weeks. Read More

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http://dx.doi.org/10.13702/j.1000-0607.180178DOI Listing
November 2018
3 Reads

Pharmacokinetics and Tissue Distribution Study of Pinosylvin in Rats by Ultra-High-Performance Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry.

Evid Based Complement Alternat Med 2018 21;2018:4181084. Epub 2018 Nov 21.

School of Pharmacy, Henan University of Chinese Medicine, No. 156, East Jinshui Road, Zhengzhou, 450046, China.

Pinosylvin is a potential anti-inflammatory and antioxidant compound and the major effective medicinal ingredient in the root of Hemsl. However, few investigations have been conducted regarding the pharmacokinetics, excretion, characteristics of tissue distribution, and major metabolites of pinosylvin in rats after oral administration. To better understand the behavior and mechanisms of action underlying the activity of pinosylvin , we established a simple, sensitive, and reliable ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for quantifying pinosylvin in rat plasma, urine, feces, and various tissues (including heart, liver, spleen, lung, kidneys, large intestine, small intestine, and stomach). Read More

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https://www.hindawi.com/journals/ecam/2018/4181084/
Publisher Site
http://dx.doi.org/10.1155/2018/4181084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280233PMC
November 2018
7 Reads

Translation elongation factor eEF1Bα is identified as a novel prognostic marker of gastric cancer.

Int J Biol Macromol 2018 Dec 17;126:345-351. Epub 2018 Dec 17.

Department of Pathology, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing 211166, China; Jiangsu Key Lab. of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Gastric cancer (GC) is a common cancer in humans. Although overexpression of eukaryotic translation elongation factor eEF1Bα is associated with cancer onset and progression, little is known about its expression in GC and its prognostic significance. Here we used immunohistochemistry to analyze eEF1Bα expression in the following tissue types: GC, normal gastric, chronic gastritis, intestinal metaplasia, and intraepithelial neoplasia. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.12.126DOI Listing
December 2018
1 Read

Autoimmune diseases in autoimmune atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):100-103. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7919DOI Listing
December 2018
10 Reads

From Sidney to OLGA: an overview of atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):93-99. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic gastritis is a long-lasting disease that can lead to a loss of appropriate gastric glands. Gastritis, as term, apply to an inflammation of the stomach, histologically proven, sometimes with structural mucosal changes. Worldwide Helicobacter pylori's infection play a pivotal role as the main etiological effector of chronic active gastritis. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7946DOI Listing
December 2018
2 Reads

Clinical manifestations of chronic atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):88-92. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7921DOI Listing
December 2018
5 Reads

Epidemiology of gastric cancer and risk factors.

Acta Biomed 2018 Dec 17;89(8-S):82-87. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Gastric cancer is, still nowadays, an important healthcare problem worldwide. In Italy, it represents the fifth tumour by frequency in both men and women over 70 years old. A crucial point is represented by the percentage of early gastric cancers usually found, which is actually very low, and it carries to a worse morbidity and mortality. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7966DOI Listing
December 2018
2 Reads

Non-invasive method for the assessment of gastric acid secretion.

Acta Biomed 2018 Dec 17;89(8-S):53-57. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Methods for the measure of gastric acid secretion include invasive and non-invasive tests. The gold-standard to measure the acid output is the collection of gastric after in basal condition (Basal Acid Output, B.A. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7986DOI Listing
December 2018
2 Reads

Relationship between Helicobacter pylori infection and GERD.

Acta Biomed 2018 Dec 17;89(8-S):40-43. Epub 2018 Dec 17.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma.

Gastroesophageal reflux disease (GERD) is due to the chronic exposure of the esophageal mucosa to acid secretion from the stomach. Helicobacter pylori (H.p. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7918DOI Listing
December 2018
1 Read

Multiple Organ Lesions in a Case of Contamination With Multiple Radionuclides After 38 Years.

Dose Response 2018 Oct-Dec;16(4):1559325818815019. Epub 2018 Dec 9.

Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China.

The patient was contaminated with multiple radionuclides 38 years ago due to an accident. To investigate the effects of radionuclide contamination on humans, he has been followed up by examinations for many years. Long-term effects gradually emerge in these years. Read More

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http://dx.doi.org/10.1177/1559325818815019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291884PMC
December 2018
2 Reads

DNA variants in Helicobacter pylori infected patients with chronic gastritis, dysplasia and gastric cancer.

Adv Med Sci 2018 Dec 13;64(1):79-84. Epub 2018 Dec 13.

Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland. Electronic address:

Purpose: The main scope of this study was to evaluate the importance of selected DNA variants for developing inflammation of gastric mucosa and carcinogenesis in gastrointestinal diseases in patients infected with Helicobacter pylori.

Patients And Methods: Patients subjected to analysis constituted a group of 131 consecutive cases, with control groups consisting of 100 healthy volunteers and 13 dyspeptic patients. Molecular analysis included the following genes: TP53 (c. Read More

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http://dx.doi.org/10.1016/j.advms.2018.12.002DOI Listing
December 2018

Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection.

Exp Biol Med (Maywood) 2018 Nov 12;243(15-16):1161-1164. Epub 2018 Dec 12.

3 Department of Medicine, University of Padova, Padova 35121, Italy.

Impact Statement: Tissue transglutaminase (t-TG) is unique among TG enzymes because of its additional role in several physiological and pathological activities, including inflammation, fibrosis, and wound healing. The presence of t-TG has previously been described in the intestine of human and animal models, yet studies on t-TG activity in human gastric mucosa are missing. Helicobacter pylori infection is the major cause of gastritis and peptic ulcers. Read More

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http://dx.doi.org/10.1177/1535370218819423DOI Listing
November 2018

Mortality rate and risk factors for gastrointestinal bleeding in elderly patients.

Eur J Intern Med 2018 Dec 4. Epub 2018 Dec 4.

First Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Background: Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.11.003DOI Listing
December 2018
2 Reads
2.300 Impact Factor

Role of Inflammasomes in the Development of Gastrointestinal Diseases.

Exp Suppl 2018 ;108:235-268

Sammons Cancer Center, Baylor Simmons Transplant Institute, Dallas, TX, USA.

Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. Read More

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http://dx.doi.org/10.1007/978-3-319-89390-7_10DOI Listing
January 2018
11 Reads

MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori.

Mol Med Rep 2019 Feb 5;19(2):1388-1395. Epub 2018 Dec 5.

Institute of Cardiovascular Disease, The 960th Hospital of Chinese PLA, Jinan, Shandong 250022, P.R. China.

Helicobacter pylori (H. pylori) infection is the major cause of chronic active gastritis and peptic ulcer disease. Upregulation of IL‑17A is associated with H. Read More

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http://dx.doi.org/10.3892/mmr.2018.9725DOI Listing
February 2019
1 Read

Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.

Pancreas 2019 Jan;48(1):131-134

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.

Our group observed the first case of synchronous gastric neuroendocrine tumor (NET) and duodenal gastrinoma with autoimmune chronic atrophic gastritis (CAG), in the absence of Helicobacter pylori infection. Demographic, clinical, endoscopic, and pathologic data were abstracted from the electronic medical record at Mount Sinai Hospital from 2013 to 2015. The patient's anonymity was carefully protected, and informed consent was obtained for publication of protected health information. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001204DOI Listing
January 2019
1 Read

Is it Necessary to Send the Sleeve Gastrectomy Specimens to Pathology?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Departments of General Surgery.

Background: Laparoscopic sleeve gastrectomy (LSG) has become more popular among other bariatric procedures. The histopathologic changes in the sleeve gastrectomy specimens have not been widely investigated among the Turkish population.

Objective: The purpose of this study was to delineate these histopathologic findings of the LSG specimens of morbidly obese patients from a single center. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000607DOI Listing
December 2018
9 Reads