5,490 results match your criteria Gastritis Atrophic

Updated Kimura-Takemoto classification of atrophic gastritis.

World J Clin Cases 2021 May;9(13):3014-3023

Department of Pathological Anatomy, Stavropol State Medical University, Stavropol 355017, Russia.

Background: The Updated Sydney system for visual evaluation of gastric mucosal atrophy endoscopic observation is subject to sampling error and interobserver variability. The Kimura-Takemoto classification system was developed to overcome these limitations.

Aim: To compare the morphological classification of atrophic gastritis between the Kimura-Takemoto system and the Updated Sydney system. Read More

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EGF and BMPs govern differentiation and patterning in human gastric glands.

Gastroenterology 2021 May 3. Epub 2021 May 3.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, 10117, Germany; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, OX3 7DQ, United kingdom. Electronic address:

Background & Aims: The homeostasis of the gastrointestinal epithelium relies on cell regeneration and differentiation into distinct lineages organised inside glands and crypts. Regeneration depends on WNT/β-Catenin pathway activation, but to understand homeostasis and its dysregulation in disease we need to identify the signalling microenvironment governing cell differentiation. By using gastric glands as a model, we have identified the signals inducing differentiation of surface mucus-, zymogen- and gastric acid- producing cells. Read More

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The Diagnostic Value of Serum Gastrin-17 and Pepsinogen for Gastric Cancer Screening in Eastern China.

Gastroenterol Res Pract 2021 12;2021:6894248. Epub 2021 Apr 12.

Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: To evaluate the diagnostic value of gastrin-17 (G-17) and pepsinogen (PG) in gastric cancer (GC) screening in China, especially eastern China, and to determine the best diagnostic combination and threshold (cutoff values) to screen out patients who need gastroscopy.

Methods: The serum concentrations of G-17 and pepsinogen I and II (PGI and PGII) in 834 patients were analyzed, and the PGI/PGII ratio (PGR) was calculated. According to pathological results, patients can be divided into chronic nonatrophic gastritis (NAG)/chronic atrophic gastritis (CAG)/intraepithelial neoplasia (IN)/GC groups. Read More

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Determination of the protective effects of Hua-Zhuo-Jie-Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites: combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing.

Chin Med 2021 May 1;16(1):37. Epub 2021 May 1.

Hebei University of Chinese Medicine, Xinshi South Road No 326, Qiaoxi District, Hebei, 050091, Shijiazhuang, China.

Background: Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes in CAG rats.

Methods: The CAG rat models were induced by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) combined with irregular fasting and 2% sodium salicylate, which was intragastrically administrated in fasted animals for 24 weeks. Read More

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[Effect of moxibustion and acupuncture on gastric mucosal cell apoptosis and expression of NF-κB, Bcl-2 in chronic atrophic gastritis rats].

Zhen Ci Yan Jiu 2021 Apr;46(4):284-8

Liuyang Hospital of Traditional Chinese Medicine, Liuyang 410300, Hunan Province.

Objective: To observe the effect of moxibustion and acupuncture on apoptosis in gastric mucosal cell and expression of NF-κB, Bcl-2 in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improvement of CAG.

Methods: Forty-eight male SD rats were randomly divided into normal, model, moxibustion and acupuncture groups, with 12 rats in each group. The CAG model was established by gavage of N-methyl-N'-nitro-N-nitroso-guanidine (MNNG) solution and irregular diet for 12 weeks. Read More

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Gastric microbiome profile throughout gastric carcinogenesis: beyond helicobacter.

Scand J Gastroenterol 2021 Apr 29:1-9. Epub 2021 Apr 29.

Department of Gastroenterology, Portuguese Oncology Institute - Porto, Porto, Portugal.

Background: Gastric dysbiosis has been hinted as a potential cause of gastric cancer. However, changes in microbiome throughout the major stages of gastric carcinogenesis remain mostly unknown.

Objective: To describe gastric microbiome at different stages, analysing for the first time dysbiosis specifically in patients with early gastric cancer (EGC). Read More

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Arq Gastroenterol 2021 Jan-Mar;58(1):39-47

Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Belo Horizonte, MG, Brasil.

Background: H. pylori chronic atrophic gastritis is a premalignant lesion, and its staging, according to OLGA and OLGIM systems aims to identify patients at increased risk of developing gastric cancer and optimize their follow-up. GastroPanel®, serum biomarkers panel including pepsinogen I (PGI), pepsinogen II (PGII), Gastrin 17 (G17) and anti- H. Read More

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Effectiveness of Banxia Xiexin Decoction in the treatment of precancerous lesions: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25607

Jiangxi University of Traditional Chinese Medicine.

Background: Gastric precancerous lesion (GPL) is a necessary stage in the occurrence and development of gastric cancer. At present, the incidence of gastric cancer is increasing year by year. It is important to prevent and control gastric cancer through early detection and intervention. Read More

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Improvement of meat protein digestibility in infants and the elderly.

Food Chem 2021 Sep 26;356:129707. Epub 2021 Mar 26.

Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, South Korea. Electronic address:

Meat is a valuable protein source with a balanced composition of essential amino acids and various nutrients. This review aims to identify methods to improve digestion of meat proteins, as well as evaluate the digestive characteristics of infants and the elderly. Immature digestive conditions in infants, including a high gastric pH and low protease concentration, can hinder protein digestion, thus resulting in inhibited growth and development. Read More

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September 2021

Expression profiling of CPS1 in Correa's cascade and its association with gastric cancer prognosis.

Oncol Lett 2021 Jun 2;21(6):441. Epub 2021 Apr 2.

Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201821, P.R. China.

Carbamoyl phosphate synthetase 1 (CPS1), which is the antigen for the hepatocyte paraffin 1 antibody, exhibits focal immunoreactivity in adenocarcinoma from the gastrointestinal tract, but its expression profiles and roles in gastric cancer (GC) remain largely unknown. The present study aimed to determine the expression pattern and prognostic value of CPS1 in Correa's cascade using tissues from 32 patients with chronic atrophic gastritis with intestinal metaplasia (IM), 62 patients with low- or high-grade intraepithelial neoplasia (IN) and 401 patients with GC. The expression of CPS1 was diffuse and strongly positive in 32 cases (100%) of IM of the glandular epithelium, and gradually downregulated in Correa's cascade, with a strongly positive ratio of 21 (70%) in low-grade IN and 4 (12. Read More

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Potential role of mitochondria in gastric cancer detection: Fission and glycolysis.

Oncol Lett 2021 Jun 1;21(6):439. Epub 2021 Apr 1.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Gastric cancer (GC) is characterized by high morbidity and mortality rates worldwide. Helicobacter pylori infection, high salt intake, smoking, alcohol, low fiber intake, family history of GC, obesity and precancerous lesions, including chronic atrophic gastritis and intestinal metaplasia, are considered general risk factors for GC. Image enhancement endoscopy methods, which improve the visualization of mucosal structures and vascularity, may be used for the early diagnosis of GC, such as narrow band imaging, which can reveal fine details of subtle superficial abnormalities of early gastric cancer (EGC). Read More

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Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis.

J Cancer 2021 19;12(10):3011-3023. Epub 2021 Mar 19.

Department of Pathology, Medical College of Soochow University, Soochow University, Suzhou, China.

Cancer-associated fibroblasts (CAFs) are principal constituents of the tumor microenvironment (TME) and play a critical role in tumor progression. The CXCL12/CXCR4 axis regulates multiple facets of the TME. The aim of this study was to determine the relationship between CXCL12 expression in CAFs and the malignant progression of gastric cancer (GC). Read More

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Iodinated BSA Nanoparticles for Macrophage-Mediated CT Imaging and Repair of Gastritis.

Anal Chem 2021 04 12;93(16):6414-6420. Epub 2021 Apr 12.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.

The development of a specific and noninvasive technology for understanding gastritic response together with efficient therapy is an urgent clinical issue. Herein, we fabricated a novel iodinated bovine serum albumin (BSA) nanoparticle based on gastritic microenvironment for computed tomography (CT) imaging and repair of acute gastritis. Derived from the characteristic mucosa defect and inflammatory cell (e. Read More

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Berberine Attenuates Chronic Atrophic Gastritis Induced by MNNG and Its Potential Mechanism.

Front Pharmacol 2021 25;12:644638. Epub 2021 Mar 25.

Department of Pharmacy, Chinese PLA General Hospital, Beijing, China.

The purpose of this study was to investigate the therapeutic effect of berberine (BBR) on MNNG-induced chronic atrophic gastritis (CAG) and the possible mechanism of BBR through TGF-β1/PI3K signal pathway. GES-1 were pretreated with MNNG for 2 h before BBR treatment in all procedures. Cell viability was quantified by cell counting kit-8, and GES-1 morphology and proliferation were detected by high content screening (HCS) assay. Read More

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Diagnostic Accuracy of EndoFaster® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study.

Gastroenterol Res Pract 2021 20;2021:6616334. Epub 2021 Mar 20.

Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Italy.

Background: EndoFaster® analyzes gastric juice in real time during gastroscopy allowing the detection of hypo-achlorhydric conditions, like corpus atrophic gastritis. Narrow-band imaging (NBI) endoscopy allows to accurately detect and perform target biopsies in areas of intestinal metaplasia, a histological change often associated to corpus atrophic gastritis.

Aims: To compare the diagnostic accuracy of EndoFaster® with histological evaluation for corpus atrophic gastritis through high-resolution (HR) NBI targeted biopsies. Read More

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The Level of Serum Pepsinogen in Diagnosing and Evaluating the Severity of Subacute Combined Degeneration Due to Vitamin B12 Deficiency.

Front Neurol 2021 19;12:604523. Epub 2021 Mar 19.

Department of Neurology, First Medical Center of Chinese PLA General Hospital, Beijing, China.

Subacute combined degeneration (SCD) is a neurological complication of cobalamin deficiency, which is usually caused by chronic autoimmune atrophic gastritis. Serum pepsinogen 1 and the ratio of pepsinogen 1/pepsinogen 2 (PG1/2) can reflect the severity of gastric atrophy. This work aims to investigate whether decreased serum PG1 and PG1/2 ratio are helpful in diagnosing SCD and reflecting the severity of SCD. Read More

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A prospective randomized tandem gastroscopy pilot study of linked color imaging versus white light imaging for detection of upper gastrointestinal lesions.

J Gastroenterol Hepatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Background And Aim: Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow-band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI. Read More

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Results of endoscopy in 35,525 patients with precancerous diseases of the gastrointestinal tract.

Int J Clin Exp Pathol 2021 1;14(3):348-354. Epub 2021 Mar 1.

Shanxi Medical University Taiyuan, China.

Background: To explore the need for the high-risk and general population to undergo endoscopy and the best age for these two groups to do so.

Material And Methods: Data on 35,525 patients who underwent endoscopy in the Endoscopic Center of Shanxi Cancer Hospital and associated medical group hospitals from January 2016 to December 2019 were collected. Two aspects of the high-risk and general population were analyzed retrospectively: 1. Read More

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Gastritis: The clinico-pathological spectrum.

Dig Liver Dis 2021 Mar 27. Epub 2021 Mar 27.

Department of Internal Medicine II, Ludwig Maximilian University Hospital, Munich, Germany.

The inflammatory spectrum of gastric diseases includes different clinico-pathological entities, the etiology of which was recently established in the international Kyoto classification. A diagnosis of gastritis combines the information resulting form the gross examination (endoscopy) and histology (microscopy). It is important to consider the anatomical/functional heterogeneity of the gastric mucosa when obtaining representative mucosal biopsy samples. Read More

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Circulating Levels of Sex Steroid Hormones and Gastric Cancer.

Arch Med Res 2021 Mar 26. Epub 2021 Mar 26.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.

Background And Aims: Men develop gastric cancer more frequently than women, yet little is known about the mechanisms underlying this sex difference. Sex steroid hormones may influence gastric cancer risk. We therefore assessed whether major circulating adrenal precursors, androgens and estrogens were associated with gastric cancer in a high-risk Mexican population. Read More

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Explore the effects of Shidan granules on chronic atrophic gastritis by LC-MS-based plasma metabolomics study.

Biomed Chromatogr 2021 Mar 29:e5129. Epub 2021 Mar 29.

Department of Gastroenterology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Shidan granule (SDG), a traditional Chinese medicine (TCM) in-hospital preparation, has been demonstrated to exert good effects on chronic atrophic gastritis (CAG) in clinic. However, the underlying mechanism of SDG against CAG was still unclear. In this study, an untargeted plasma metabolomics approach was utilized to explore the potential mechanism of SDG in the CAG rats using LC-MS and pattern recognition analysis. Read More

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Lessons learned from upper gastrointestinal endoscopy in asymptomatic Chinese.

Helicobacter 2021 Jun 29;26(3):e12803. Epub 2021 Mar 29.

Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: The Helicobacter pylori (H. pylori) infection-related diseases, peptic ulcer, and gastric cancer are frequently asymptomatic until the onset of complications. This study aimed to investigate the prevalence of H. Read More

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Salivary Microbiota for Gastric Cancer Prediction: An Exploratory Study.

Front Cell Infect Microbiol 2021 10;11:640309. Epub 2021 Mar 10.

Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China.

To characterize the salivary microbiota in patients at different progressive histological stages of gastric carcinogenesis and identify microbial markers for detecting gastric cancer, two hundred and ninety-three patients were grouped into superficial gastritis (SG; n = 101), atrophic gastritis (AG; n = 93), and gastric cancer (GC; n = 99) according to their histology. 16S rRNA gene sequencing was used to access the salivary microbiota profile. A random forest model was constructed to classify gastric histological types based on the salivary microbiota compositions. Read More

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Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages.

Front Cell Infect Microbiol 2021 3;11:559148. Epub 2021 Mar 3.

Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: Microbial infections have been shown to contribute to gastric carcinogenesis, the knowledge of gastric microbiota alteration in this process may provide help in early diagnosis of gastric cancer. The aim of this study was to characterize the microbial changes and identify taxonomic biomarkers across stages of gastric carcinogenesis.

Methods: The gastric microbiota was investigated by 16S rRNA gene analysis in gastric mucosal specimens from 47 patients including superficial gastritis (SG), atrophic gastritis (AG), gastric intraepithelial neoplasia (GIN), and gastric cancer (GC). Read More

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EPRS/GluRS promotes gastric cancer development via WNT/GSK-3β/β-catenin signaling pathway.

Gastric Cancer 2021 Mar 19. Epub 2021 Mar 19.

Department of Pathophysiology, School of Basic Medical Sciences, Academy of Medical Science, College of Medicine, Zhengzhou University, Zhengzhou, 450001, Henan, China.

Background: Glutamyl-prolyl-tRNA synthetase (EPRS/GluRS) is primarily part of the multi-synthetase complex that may play a key role in cancer development. However, the biological function, molecular mechanism, and inhibitor of EPRS have not been investigated in gastric cancer (GC).

Methods: Immunohistochemistry was performed to detect the expression of EPRS in human gastric tumor tissues. Read More

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Characterization of Chronic Gastritis in Lynch Syndrome Patients With Gastric Adenocarcinoma.

Gastroenterology Res 2021 Feb 19;14(1):13-20. Epub 2021 Feb 19.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.

Background: Gastric cancer is one of the Lynch syndrome (LS)-associated malignancies. Previous studies have suggested that LS patients with gastric cancer also had chronic atrophic gastritis in the background mucosa, but further histologic characterization was not attempted. This study aims to understand the histologic features of background chronic gastritis in LS patients with gastric adenocarcinoma. Read More

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February 2021

Objective Evidence of Gastro-Esophageal Reflux Disease is Rare in Patients with Autoimmune Gastritis.

J Gastrointestin Liver Dis 2021 Mar 13;30(1):30-36. Epub 2021 Mar 13.

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

Background And Aims: Patients with autoimmune atrophic gastritis (AAG) often complain of acid reflux symptoms, despite the evidence of hypo-achlorhydria. Rome IV criteria are used to define functional esophageal disorders. Our aim was to characterize gastroesophageal reflux disease (GERD) phenotypes in patients with AAG. Read More

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Chronic atrophic gastritis and intestinal metaplasia induced by high-salt and N-methyl-N'-nitro-N-nitrosoguanidine intake in rats.

Exp Ther Med 2021 Apr 3;21(4):315. Epub 2021 Feb 3.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.

The aim of the present study was to induce chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) in rats by administering saturated salt and methyl-N'-nitro-N-nitrosoguanidine (MNNG) via oral gavage. Changes in gastric mucosal blood microcirculation and activation of the cyclo-oxygenase-2 (COX-2)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway during CAG and IM development were investigated. After administering saturated salt and MNNG for 25 weeks, mild atrophy was detected in the stomach of model rats using hematoxylin and eosin staining. Read More

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Systematic upper endoscopy concomitant with colonoscopy performed within the colorectal cancer screening program: Impact on the patients' management.

Clin Res Hepatol Gastroenterol 2021 Mar 11;45(3):101501. Epub 2021 Mar 11.

Institut des Maladies de l'appareil Digestif, Hépato-Gastroentérologie & Oncologie Digestive, Hôtel Dieu, Nantes University Hospital, 1 place Alexis Ricordeau, Nantes 44093, France.

Background And Aims: The French colorectal cancer screening program is based on a fecal immunochemical test, followed by colonoscopy in case of positivity. The benefit of adding a concomitant upper endoscopy to detect upper digestive lesions (precancerous or others) is still debated. Our aim was to evaluate the frequency of upper digestive lesions detected by upper endoscopy performed concomitantly with colonoscopy following a positive fecal immunochemical test, and their impact on the patients' management (i. Read More

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Changes of F-fluoro-2-deoxyglucose position-emission tomography findings by the eradication of Helicobacter pylori in the stomach.

Helicobacter 2021 Jun 8;26(3):e12797. Epub 2021 Mar 8.

Department of Gastroenterology and Hepatology, Kusunoki Hospital, Fujioka, Japan.

Purpose: Helicobacter pylori (HP) infection is reported to increase F-fluoro-2-deoxyglucose (FDG) accumulation in the stomach. The accumulation of FDG by positron-emission tomography (FDG-PET) in the stomach for the voluntary health examinees of cancer checkup was examined before and after the HP eradication.

Subjects And Methods: From March 2013 to October 2015, eighty-one subjects were performed FDG-PET to detect cancer at the health checkup. Read More

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