5,705 results match your criteria Gastritis Atrophic


Role of magnifying narrow-band imaging endoscopy for diagnosis of infection and gastric precancerous conditions: Few issues.

World J Gastroenterol 2022 Apr;28(15):1601-1603

Department of Gastroenterology, IMS and SUM Hospital, SOA University, Bhubaneswar 751003, Odisha, India.

Standard endoscopy with biopsy and narrow-band imaging with guided biopsy are techniques for the detection of -related gastritis and precancerous lesions. In this study, the authors compared standard endoscopy and magnified narrow-band imaging (commonly known as NBI-M) in the diagnosis of infections, atrophic gastritis, and intestinal metaplasia. Although the sensitivity of NBI-M is better than standard endoscopy, the diagnostic accuracy did not differ substantially between the diagnostic modalities. Read More

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Evaluation of Trefoil Factor 3 as a Non-Invasive Biomarker of Gastric Intestinal Metaplasia and Gastric Cancer in a High-Risk Population.

Gastroenterol Hepatol 2022 May 14. Epub 2022 May 14.

Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Operative Group of Chilean Association of Digestive Endoscopy (ACHED), Santiago, Chile.

Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal metaplasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia.

Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer. Read More

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Differential Long Non-Coding RNA Expression Analysis in Chronic Non-Atrophic Gastritis, Gastric Mucosal Intraepithelial Neoplasia, and Gastric Cancer Tissues.

Front Genet 2022 27;13:833857. Epub 2022 Apr 27.

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Gastric cancer (GC) has a high incidence worldwide, and when detected, the majority of patients have already progressed to advanced stages. Long non-coding RNAs (lncRNAs) have a wide range of biological functions and affect tumor occurrence and development. However, the potential role of lncRNAs in GC diagnosis remains unclear. Read More

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Efficacy and safety of Chinese herbal medicine Qirui Weishu capsule in treating chronic non-atrophic gastritis: A multicentre, double-blind, randomized controlled clinical trial.

J Ethnopharmacol 2022 May 9:115341. Epub 2022 May 9.

Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei, 430060, PR China. Electronic address:

Ethnopharmacological Relevance: QiruiWeishu capsule is an herbal preparation from a herbal formula prescribed by an experienced doctor at Guang'anmen Hospital of China Academy of Chinese Medical Sciences. It has been used clinically for more than 30 years. Abdominal pain, distension, and nausea are common symptoms of chronic non-atrophic gastritis with erosion dampness and heat stasis syndrome, and this herbal medicine has been used to treat them. Read More

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[Aberrant Expression and Glycosylation of Mucins in Gastric Mucosal Disease].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Apr;44(2):294-298

Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730, China.

Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer. Read More

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Serum Pepsinogen as a Biomarker for Gastric Cancer in the United States: A Nested Case-Control Study using the PLCO Cancer Screening Trial Data.

Cancer Epidemiol Biomarkers Prev 2022 May 9. Epub 2022 May 9.

Duke University School of Medicine, Durham, NC, United States.

Background: Gastric cancer (GC) lacks specific symptoms, resulting in diagnosis at later stages and high mortality. Serum pepsinogen is a biomarker for atrophic gastritis, a GC precursor, and may be useful to detect persons at increased risk of GC.

Methods: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial was conducted in the US between 1993 and 2001. Read More

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Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.

Front Endocrinol (Lausanne) 2022 22;13:860880. Epub 2022 Apr 22.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Hashimoto thyroiditis (HT) is an autoimmune disease which may result in extensive damage of the thyroid gland. Chronic atrophic gastritis (CAG), is the most frequent HT-associated disorder, with anti-parietal cell autoantibodies (APCA) being a screening test for autoimmune CAG. The aim of this study was to investigate, in a cohort of HT patients: a) the prevalence of APCA in an attempt to define their clinical phenotype and b) any possible associations of APCA with other autoimmune diseases and malignancies. Read More

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The Potential Role of Hypochlorhydria in the Development of Duodenal Dysbiosis: A Preliminary Report.

Front Cell Infect Microbiol 2022 19;12:854904. Epub 2022 Apr 19.

Department of Translational and Precision Medicine, University of Rome "Sapienza", Rome, Italy.

In recent years, the role of gastric and duodenal microbiota has acquired increasing importance in the homeostasis of the host, although, to date, most evidence concern the faecal microbiota. Indeed, the gastric, and duodenal microbiota are challenging to study, due to gastric acid, bile, digestive enzymes, and rapid transit time. Specifically, the gastric acid environment may influence their bacterial composition since the acid barrier protects against orally ingested microorganisms and leads to their inactivation before reaching the intestine. Read More

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Occurrences and phenotypes of RIPK3-positive gastric cells in Helicobacter pylori infected gastritis and atrophic lesions.

Dig Liver Dis 2022 May 2. Epub 2022 May 2.

Research Group of Gastrointestinal Diseases, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Background: Research evidences suggest that diverse forms of programmed cell death (PCD) are involved in the helicobacter pylori (H. pylori)-induced gastric inflammation and disorders.

Aims: To characterize occurrences and phenotypes of necroptosis in gastric cells in H. Read More

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Inflammatory map of the gastroduodenal mucosa in patients with upper gastrointestinal symptoms. The role of H. pylori infection.

Rev Gastroenterol Mex (Engl Ed) 2022 May 1. Epub 2022 May 1.

Universidad de Granada, Granada, Spain.

Introduction And Aim: The gastric mucosa has been studied since the pre-Helicobacter pylori (H. pylori) era, but the complete descriptions of the stomach and duodenum have been anecdotal, and those of the distal duodenum, exceptional. Our aim was to evaluate the different epidemiologic characteristics and the gastroduodenal inflammatory status in patients with upper gastrointestinal symptoms. Read More

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Prevalence of Gastric Preneoplastic Lesions in First-Degree Relatives of Patients with Gastric Cancer: a Cross-Sectional Study.

J Gastrointest Cancer 2022 Apr 30. Epub 2022 Apr 30.

Faculty of Medicine, Universidad Católica del Maule, Talca, Chile.

Purpose: Worldwide, gastric cancer (GC) is the 5 cancer with the highest incidence and the 4 in mortality. To reduce it, one strategy is to diagnose preneoplastic lesions (PNL): atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia (DYS); to form risk groups on which to focus surveillance efforts as are first-degree relatives (FDR). The aim of this study was to determine prevalence of gastric PNL in FDR of patients with GC, and to study association with sex, age, and Helicobacter pylorii (Hp) infection. Read More

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Levothyroxine treatment and gastric juice pH in humans: the proof of concept.

Endocrine 2022 Apr 27. Epub 2022 Apr 27.

Department of Medico-surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.

Purpose: Despite the absorption of oral thyroxine (T4) occurs in the small bowel, several patients with gastric disorders show an increased need for T4. In vitro evidence suggested that medium pH variations interfere with T4 dissolution. This study was aimed at finding the proof of concept of a direct relationship between the minimal effective dose of T4 and the actual gastric juice pH. Read More

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Comparison of the effectiveness of i-scan and conventional endoscopy in the detection of the endoscopic signs of atrophic gastritis: A clinical trial.

Arab J Gastroenterol 2022 Apr 23. Epub 2022 Apr 23.

Department of General Surgery, Cerrahpasa Medical Faculty, İstanbul University- Cerrahpasa, İstanbul, Turkey.

Background And Study Aims: This study aimed to determine whether the use of i-scan endoscopy provides additional benefits to conventional endoscopy in the diagnosis of gastric precancerous lesions.

Patients And Methods: A total of 120 patients with histologically-verified intestinal metaplasia (IM) or atrophic gastritis (AG) were prospectively evaluated by esophagogastroduodenoscopy. Endoscopic examinations were performed using i-scan and high-definition white-light endoscopy (HD-WLE). Read More

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Therapeutic effect of Qinghuayin against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-containing adaptor inducing interferon-β signaling pathway.

J Tradit Chin Med 2022 Apr;42(2):221-226

Department of Gastroenterology, the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China.

Objective: To examine the efficacy of Qinghuayin (, QHY) in rat chronic atrophic gastritis (CAG) models and explored the molecular mechanism of QHY in treating CAG.

Methods: In total, 65 Wistar rats were randomly divided into the control (= 10) and CAG groups ( = 55). CAG model rats were further divided into five groups: model ( = 10), vitacoenzyme ( = 10), low-dose QHY ( = 10), medium-dose QHY ( = 10), and high-dose QHY groups ( = 10). Read More

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Gender-sex differences in autoimmune atrophic gastritis.

Transl Res 2022 Apr 22. Epub 2022 Apr 22.

Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, University Sapienza, Rome, Italy.

Gender-sex differences in autoimmune diseases are gaining increasing attention due to their effects on prevalence and clinical features. Data on gender-sex differences in autoimmune atrophic gastritis (AAG), a chronic not-self-limiting inflammatory condition characterized by corpus-oxyntic mucosa atrophy sparing the antrum, are lacking. This study aimed to assess possible gender-sex differences of clinical, serological, histological, and genetic features in AAG patients. Read More

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Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency.

Nutrients 2022 Apr 17;14(8). Epub 2022 Apr 17.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sant'Andrea Hospital, University Sapienza, 00189 Rome, Italy.

Pernicious anemia is still a neglected disorder in many medical contexts and is underdiagnosed in many patients. Pernicious anemia is linked to but different from autoimmune gastritis. Pernicious anemia occurs in a later stage of autoimmune atrophic gastritis when gastric intrinsic factor deficiency and consequent vitamin B deficiency may occur. Read More

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Do Gastric Signet Ring Cell Carcinomas and ECL-Cell Neuroendocrine Tumours Have a Common Origin?

Medicina (Kaunas) 2022 Mar 23;58(4). Epub 2022 Mar 23.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.

Gastric cancer is a heterogenous group of tumours, and a better understanding of the carcinogenesis and cellular origin of the various sub-types could affect prevention and future treatment. Gastric neuroendocrine tumours (NETs) and adenocarcinomas that develop in the gastric corpus and fundus of patients with chronic atrophic gastritis have atrophic gastritis, hypoacidity, and hypergastrinemia as common risk factors and a shared cellular origin has been suggested. In particular, signet ring cell carcinomas have previously been suggested to be of neuroendocrine origin. Read More

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Efficacy of high-vision transnasal endoscopy using texture and colour enhancement imaging and narrow-band imaging to evaluate gastritis: a randomized controlled trial.

Ann Med 2022 Dec;54(1):1004-1013

Department of Gastroenterological Endoscopy, Tokyo Medical University Hospital, Tokyo, Japan.

Background: A new image-enhanced endoscopy method called texture and colour enhancement imaging (TXI) enhances brightness, surface irregularities, and subtle colour changes in endoscopic images. However, it is unclear whether TXI and narrow-band imaging (NBI) with third-generation high-vision transnasal ultrathin endoscopy are advantageous over white-light imaging (WLI) for detecting atrophy, intestinal metaplasia, map-like redness and gastric cancer. We investigated to compare the endoscopic efficacy for evaluation of gastritis between TXI and NBI with high-vision transnasal endoscopy and clarified the endoscopic efficacy of TXI and NBI compared to WLI. Read More

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December 2022

Multidisciplinary diagnosis and treatment of undifferentiated gastric cancer with a specific morphology: a case report.

Ann Transl Med 2022 Mar;10(6):382

Gastroenterology Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), Nanjing, China.

Background: Due to ongoing research on digestive endoscopy, early gastric cancer has become a popular topic. Based on macro-research on morphology using the Paris endoscopic classification system and micro-explorations of histopathology under endoscopy, several researchers have organically combined endoscopy with pathology and surgery. This multidisciplinary combination of digestive endoscopy could improve the diagnosis rate and cure rate of early gastric cancer. Read More

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Endoscopic diagnosis of gastric intestinal metaplasia in patients with autoimmune gastritis using narrow-band imaging: does pseudopyloric metaplasia muddy the waters?

Endosc Int Open 2022 Apr 14;10(4):E434-E440. Epub 2022 Apr 14.

Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

 In autoimmune atrophic gastritis (AAG), associated with intestinal (IM) and/or pseudopyloric metaplasia (PPM), endoscopic surveillance is recommended for gastric cancer risk mainly linked to IM. Endoscopic Grading of Gastric Intestinal Metaplasia (EGGIM) reliably identifies IM, but has not been assessed in AAG. We aimed to assess the performance of EGGIM (index test) versus histology (reference test) of corpus IM in AAG. Read More

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Newly proposed quantitative criteria can assess chronic atrophic gastritis via probe-based confocal laser endomicroscopy (pCLE): a pilot study.

Endosc Int Open 2022 Apr 14;10(4):E297-E306. Epub 2022 Apr 14.

Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas (IECED), Guayaquil, Ecuador.

 Probe-based confocal laser endomicroscopy (pCLE) can provide high magnification to evaluate chronic atrophic gastritis (CAG), but the current pCLE criteria are qualitative and prone to variability. We aimed to propose a quantitative CAG criterion based on pCLE to distinguish non-atrophic gastritis (NAG) from CAG. This observational, exploratory pilot study included patients with NAG and CAG evaluated via esophagogastroduodenoscopy, pCLE, and histology. Read More

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SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.

Cell Oncol (Dordr) 2022 Apr 14. Epub 2022 Apr 14.

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Dalian Road 149, Zunyi, 563000, China.

Background: Solute carrier family 26 member (SLC26A9) is a Cl uniporter with very high expression levels in the gastric mucosa. Here, we describe morphological and molecular alterations in gastric mucosa of slc26a9 mice and in selective parietal cell-deleted slc26a9/Atp4b-Cre mice and correlate SLC26A9 expression levels with morphological and clinical parameters in a cohort of gastric cancer (GC) patients.

Methods: The expression patterns of genes related to transport and enzymatic function, proliferation, apoptosis, inflammation, barrier integrity, metaplasia and neoplasia development were studied by immunohistochemistry (IHC), quantitative RT-PCR, in situ hybridization and RNA microarray analysis. Read More

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Gastric neuroendocrine neoplasms: a primer for radiologists.

Abdom Radiol (NY) 2022 Apr 12. Epub 2022 Apr 12.

Department of Radiology, Michigan Medicine, University of Michigan, 1500 East Medical Center Drive, B1D502, Ann Arbor, MI, 48109, USA.

Gastric neuroendocrine neoplasms are uncommon tumors with variable differentiation and malignant potential. Three main subtypes are recognized: type 1, related to autoimmune atrophic gastritis; type 2, associated with Zollinger-Ellison and MEN1 syndrome; and type 3, sporadic. Although endoscopy alone is often sufficient for diagnosis and management of small, indolent, multifocal type 1 tumors, imaging is essential for evaluation of larger, high-grade, and type 2 and 3 neoplasms. Read More

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Morphogen Signals Shaping the Gastric Glands in Health and Disease.

Int J Mol Sci 2022 Mar 26;23(7). Epub 2022 Mar 26.

Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, UK.

The adult gastric mucosa is characterised by deep invaginations of the epithelium called glands. These tissue architectural elements are maintained with the contribution of morphogen signals. Morphogens are expressed in specific areas of the tissue, and their diffusion generates gradients in the microenvironment. Read More

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Confocal Laser Endomicroscopy Can Improve the Diagnosis Rate and Range Assessment of Patients With Conflicting Chronic Atrophic Gastritis Results of White Light Endoscopic and Pathological Diagnosis.

Front Oncol 2022 24;12:809822. Epub 2022 Mar 24.

Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background And Aims: Chronic atrophic gastritis (CAG) is closely related to the development of gastric cancer. However, the diagnostic accuracy of white light endoscopy (WLE) biopsy for CAG is poor. The diagnostic role and efficacy of confocal laser endomicroscopy (CLE) in CAG missed under WLE biopsy remain unclear. Read More

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Urease Levels and Gastritis Stage in Dyspeptic Patients.

Acta Med Indones 2022 Jan;54(1):42-51

1. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia 2. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia 3. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan.

Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Read More

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January 2022

Endoscopic scoring system for gastric atrophy and intestinal metaplasia: correlation with OLGA and OLGIM staging: a single-center prospective pilot study in Korea.

Scand J Gastroenterol 2022 Apr 6:1-8. Epub 2022 Apr 6.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background/aims: We aimed to develop an endoscopic scoring system to evaluate gastric atrophy and intestinal metaplasia using narrow-band imaging (NBI) and near focus mode (NFM) to compare endoscopic scores with the Operative link for gastritis assessment (OLGA) and the Operative link for gastric intestinal metaplasia assessment (OLGIM).

Methods: A total of 51 patients who underwent diagnostic esophagogastroduodenoscopy were prospectively enrolled and endoscopic scoring using NBI and NFM was performed. Four areas (the lesser and greater curvatures of the antrum and the lesser and greater curvature side of the corpus) were observed and biopsies were taken. Read More

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Non-conventional types of dysplastic changes in gastrointestinal tract mucosa - review of morphological features of individual subtypes.

Cesk Patol 2022 ;58(1):38-51

Evaluation of the dysplastic changes evolving in mucosa of various segments of gastrointestinal tract is a part of routine practice. Morphologically different or non-conventional types of dysplastic changes are described in the mucosa of gastrointestinal tract besides the most common conventional type of dysplasia. Non-conventional dysplasias can arise de-novo or they can be found in association with chronic gastrointestinal conditions, such as Barretts esophagus, chronic atrophic gastritis, and inflammatory bowel disease. Read More

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Systematic review and meta-analysis: Artificial intelligence for the diagnosis of gastric precancerous lesions and Helicobacter pylori infection.

Dig Liver Dis 2022 Apr 2. Epub 2022 Apr 2.

Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa, Roma 1035 - 00189, Italy. Electronic address:

Background: The endoscopic diagnosis of Helicobacter-pylori(H.pylori) infection and gastric precancerous lesions(GPL), namely atrophic-gastritis and intestinal-metaplasia, still remains challenging. Artificial intelligence(AI) may represent a powerful resource for the endoscopic recognition of these conditions. Read More

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The 'reversibility' of chronic atrophic gastritis after the eradication of .

Postgrad Med 2022 Apr 13:1-6. Epub 2022 Apr 13.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Gram-negative bacterium () infection is lifelong and usually acquired in childhood, which is etiologically linked to gastric cancer (GC). gastritis is defined as an infectious disease with varying severity in virtually all infected subjects. Chronic atrophic gastritis (CAG) is the precancerous condition with the decrease or the loss of gastric glands, which can further be replaced by metaplasia or fibrosis. Read More

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