5,254 results match your criteria Gastritis Atrophic


Association of infection with colorectal polyps and malignancy in China.

World J Gastrointest Oncol 2020 May;12(5):582-591

Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.

Background: Gastric () infection is related to chronic gastritis, gastroduodenal ulcer, and gastric malignancies; whether this infection is related to colorectal polyps and colorectal cancer (CRC), remains debatable.

Aim: To investigate the relationship between gastric infection and the risk of colorectal polyps and CRC.

Methods: We retrospectively analyzed 3872 patients with colorectal polyps who underwent colonoscopy and pathological diagnosis. Read More

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http://dx.doi.org/10.4251/wjgo.v12.i5.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235179PMC

Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Esophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic esophagitis, lichen planus, and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic esophagitis is an emerging chronic atopic disease with esophageal dysfunction as the typical presentation, and esophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

Bullous pemphigoid associated chronic atrophic gastritis.

Dermatol Ther 2020 May 24:e13671. Epub 2020 May 24.

Department of Dermatology, Allergology and Venereology, Helsinki University Hospital.

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http://dx.doi.org/10.1111/dth.13671DOI Listing

[Acupoint catgut embedding improves gastric mucosal injury by down-regulating expression of HIF-1α and VEGF in chronic atrophic gastritis rats].

Zhen Ci Yan Jiu 2020 May;45(5):384-8

Renhe Chinese Medicine Hospital, Foshan 528244, Guangdong Province.

Objective: To observe the effect of acupoint catgut embedding on histopathological changes of gastric mucosa and expression of mucosal hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) proteins in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improvement of CAG.

Methods: Male SD rats were divided into blank group (=10) and model group (=9) and catgut embedment group (=10). The CAG model was established by free drinking of N-methyl-N'-nitro-N-nitroso-guanidine solution (100 μg/mL) and irregular diet. Read More

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http://dx.doi.org/10.13702/j.1000-0607.190189DOI Listing

Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study.

Asia Pac Allergy 2020 Apr 23;10(2):e16. Epub 2020 Apr 23.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

Background: Eosinophilic esophagitis (EoE) is an allergy-associated clinicopathologic condition gaining an increasing amount of recognition in various areas of the world. While the clinical definition and characteristics may differ depending on country and region, sufficient studies have not yet been performed in Japan.

Objective: To assess the prevalence of EoE among the Japanese population and the clinical features associated with the disease. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203441PMC

Type 1 diabetes, thyroid, gastric and adrenal humoral autoantibodies are present altogether in almost one third of adult celiac patients at diagnosis, with a higher frequency than children and adolescent celiac patients.

Scand J Gastroenterol 2020 May 12:1-6. Epub 2020 May 12.

Department of Internal Medicine and Clinical Specialties, "Sapienza" University of Rome, Rome, Italy.

No data are available on the frequency of organ-specific humoral autoimmunity at diagnosis of adult celiac disease (CD). To evaluate the humoral immunoreactivities specific of type 1 diabetes (T1D), thyroid (THD), atrophic-gastritis (AG) and Addison's (AD) diseases in 92 adult CD patients at diagnosis and 237 adult healthy subjects (CTRL). T1D, THD and AD specific autoantibodies were analyzed by radioimmunoprecipitation assays. Read More

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http://dx.doi.org/10.1080/00365521.2020.1754898DOI Listing

Effectiveness of Helicobacter pylori eradication in preventing metachronous gastric cancer and preneoplastic lesions. A systematic review and meta-analysis.

Eur J Gastroenterol Hepatol 2020 May 2. Epub 2020 May 2.

Department of Gastroenterology and Hepatology, Minneapolis VA Medical Center, Minneapolis, Minnesota, USA.

Background: Helicobacter pylori is a significant risk factor for gastric cancer. Recent trials show eradication decreases the incidence of gastric cancer in patients with early-stage gastric cancer. However, data on gastric cancer prevention are inconsistent for patients with precancerous lesions such as atrophic gastritis and intestinal metaplasia. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001740DOI Listing
May 2020
2.152 Impact Factor

Recent Guidelines on the Management of Patients with Gastric Atrophy: Common Points and Controversies.

Dig Dis Sci 2020 Apr 30. Epub 2020 Apr 30.

Institute of Clinical and Preventive Medicine, University of Latvia, 19 Raiņa Blvd., Riga, LV1586, Latvia.

Patients with gastric precancerous lesions (atrophic gastritis and intestinal metaplasia) have increased risk of developing gastric cancer, and adequate management and surveillance of these patients should allow to reduce gastric cancer-related mortality. The guidelines on the management of these patients have been recently published by the European Societies (MAPS II guidelines) and by the American Gastroenterological Association (AGA). The aim of this commentary is to compare these two guidelines by highlighting the common points and differences between them. Read More

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http://dx.doi.org/10.1007/s10620-020-06272-9DOI Listing

Effectiveness of Helicobacter pylori eradication in preventing metachronous gastric cancer and preneoplastic lesions. A systematic review and meta-analysis.

Eur J Gastroenterol Hepatol 2020 Jun;32(6):686-694

Department of Gastroenterology and Hepatology, Minneapolis VA Medical Center, Minneapolis, Minnesota, USA.

Background: Helicobacter pylori is a significant risk factor for gastric cancer. Recent trials show eradication decreases the incidence of gastric cancer in patients with early-stage gastric cancer. However, data on gastric cancer prevention are inconsistent for patients with precancerous lesions such as atrophic gastritis and intestinal metaplasia. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001740DOI Listing
June 2020
2.152 Impact Factor

Chemoprevention of gastric cancer development after eradication therapy in an East Asian population: Meta-analysis.

World J Gastroenterol 2020 Apr;26(15):1820-1840

Department of Gastroenterology, Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita 8795593, Japan.

Background: () infection is a risk factor for gastric cancer (GC), especially in East Asian populations. Most East Asian populations infected with are at higher risk for GC than -positive European and United States populations. eradication therapy reduces gastric cancer risk in patients after endoscopic and operative resection for GC, as well as in non-GC patients with atrophic gastritis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i15.1820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183870PMC

Effects of Helicobacter pylori on the glutathione-related pathway in gastric epithelial cells.

Biochem Biophys Res Commun 2020 Jun 17;526(4):1118-1124. Epub 2020 Apr 17.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Virulence factors of Helicobacter pylori (H. pylori) are diverse, so various biological responses happen in a host infected with H. pylori. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.04.019DOI Listing

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer.

Oxid Med Cell Longev 2020 28;2020:3457890. Epub 2020 Mar 28.

Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil.

Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer. We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports. Read More

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http://dx.doi.org/10.1155/2020/3457890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146093PMC

Evaluation of C5orf66-AS1 as a Potential Biomarker for Predicting Early Gastric Cancer and Its Role in Gastric Carcinogenesis.

Onco Targets Ther 2020 2;13:2795-2805. Epub 2020 Apr 2.

Tumor Etiology and Screening Department of Cancer Institute, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Background: Long non-coding RNAs (lncRNAs) participate in a series of pathological processes in tumorigenesis. Reports show that C5orf66-AS1, an antisense lncRNA, is expressed in various tumors. However, the role of C5orf66-AS1 in gastric cancer (GC) has not been fully clarified. Read More

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http://dx.doi.org/10.2147/OTT.S239965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136487PMC

Network pharmacology research of Astragali Radix in treating chronic atrophic gastritis rats based on mitochondrial metabonomics.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 May 9;1145:122109. Epub 2020 Apr 9.

Modern Research Center for Traditional Chinese Medicine of Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, Shanxi, PR China. Electronic address:

Astragali Radix (HuangQi), one important traditional Chinese herb, is used for treatment of chronic atrophic gastritis (CAG). To comprehensively evaluate its regulation on CAG, a mitochondria-specific metabonomics was applied to reveal its action on energy metabolism based on ultra high performance liquid chromatography coupled with quadrupole - Exactive mass spectrometry. 16 related metabolites from mitochondria samples were served as potential biomarkers of CAG. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122109DOI Listing

Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer.

Sci Rep 2020 Apr 16;10(1):6570. Epub 2020 Apr 16.

Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, MI, USA.

Helicobacter pylori (HP) colonizes the human stomach and induces acute gastritis, peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma. Increased virulence in HP isolates derives from harboring the cag (cytotoxin-associated genes) pathogenicity island (cagPAI). We analyzed the microvariants in cagPAI genes with the hypothesis that they may play an important role in determining HP virulence. Read More

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http://dx.doi.org/10.1038/s41598-020-63463-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162905PMC

E-Cadherin Protein as a Potential Marker for Gastric Cancer and Its Association with - Induced Gastritis and Gastric Ulcer.

Rep Biochem Mol Biol 2019 Oct;8(3):269-277

Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq.

Background: Gastric cancer is still the main health threat being the third leading cause of deaths from cancers in the world. The major risk behind the gastric cancer is that it remains asymptomatic in the early stages and in (97%) cases it metastasizes to other organs. Gastric cancer is a multifactorial disease in which has been known as a risk factor. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103084PMC
October 2019

Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations.

PLoS One 2020 9;15(4):e0230064. Epub 2020 Apr 9.

Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.

Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; however, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangladesh, Bhutan, Indonesia, Myanmar, Nepal and Thailand then assessed the association between gastric mucosal changes and Helicobacter pylori infection. The new cutoff values for serum pepsinogen values were evaluated using a receiver operating characteristic analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230064PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145115PMC
April 2020
3.234 Impact Factor

[Effect of heat-sensitive moxibustion at "Zhongwan" (CV 12) on serum GH and PG in chronic atrophic gastritis rats].

Zhongguo Zhen Jiu 2020 Mar;40(3):279-84

Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of TCM, Nanchang 330006, China.

Objective: To observe the effect of heat-sensitive moxibustion at "Zhongwan" (CV 12) on serum growth hormone (GH) and pepsinogen (PG) in chronic atrophic gastritis (CAG) rats, and to explore the potential mechanism of heat-sensitive moxibustion for CAG.

Methods: A total of 66 male SD rats were randomized into a blank group (12 rats) and a model establishment group (54 rats). No intervention was given in the blank group. Read More

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http://dx.doi.org/10.13703/j.0255-2930.20190224-k0002DOI Listing

Optical enhancement imaging versus acetic acid for detecting gastric intestinal metaplasia: A randomized, comparative trial.

Dig Liver Dis 2020 Apr 4. Epub 2020 Apr 4.

Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Background And Aims: The diagnosis of gastric intestinal metaplasia (GIM) is still challenging. Optical Enhancement technology (OE) may improve the detection of GIM. We compared detection of GIM with OE, acetic acid and the Sydney biopsy protocol in a surveillance population. Read More

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http://dx.doi.org/10.1016/j.dld.2020.02.010DOI Listing
April 2020
2.963 Impact Factor

Noneffectiveness of scopolamine for facilitating detection of upper gastrointestinal neoplasia during screening esophagogastroduodenoscopy: propensity score-matched study.

Endoscopy 2020 Apr 6. Epub 2020 Apr 6.

Gastroenterology Division, St. Luke's International University, Tokyo, Japan.

Background:  Antispasmodics, such as scopolamine, are widely used in several countries prior to diagnostic and screening esophagogastroduodenoscopy (EGD), with the goal of optimizing the detection of minute lesions, typically early gastric cancer (T1 lesions). The aim of this study was to determine whether scopolamine facilitates detection of gastric cancer in the screening setting.

Methods: A propensity score-matched retrospective study was conducted in a tertiary referral medical center in Tokyo, Japan. Read More

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http://dx.doi.org/10.1055/a-1130-6127DOI Listing

Statistical analysis of the сhronic gastritis in students.

Wiad Lek 2020 ;73(2):360-364

Poltava V.G. Korolenko National Pedagogical University, Poltava, Ukraine.

Objective: The aim: The aim of the study is a statistical analysis of the mucosa of the stomach affected by Helicobacter pylori in young people studying at the university.

Patients And Methods: Materials and methods: The work contains the results of the study of chronic gastritis of type B in university volunteer students. The study was attended by students of 1-4courses, aged 17 to 25 years, a total of 50 people. Read More

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LncRNAs adjacent to pepsinogen C in gastric diseases and diagnostic efficiencies of joint detection in gastric diseases.

Future Oncol 2020 Apr 3;16(11):655-663. Epub 2020 Apr 3.

Tumor Etiology & Screening Department of Cancer Institute & General Surgery, the First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.

We aimed to explore diagnostic efficiencies of long noncoding RNAs (lncRNAs) adjacent to combining with sPGC and anti- IgG in identifying GC (gastric cancer) and precancerous disease. : A total of 265 patients with different gastric diseases were collected. ELISA was to detect sPGC and anti- IgG. Read More

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http://dx.doi.org/10.2217/fon-2019-0833DOI Listing

Upper socioeconomic status is associated with lower Helicobacter pylori infection rate among patients undergoing gastroscopy.

J Infect Dev Ctries 2020 Mar 31;14(3):298-303. Epub 2020 Mar 31.

Division of Gastroenterology and Hepatology, American Hospital, Istanbul, Turkey.

Introduction: Socioeconomic factors play an important role in the prevalence of Helicobacter pylori (HP) infection. The aim of this study is to investigate HP prevalence among symptomatic patients in the upper socioeconomic segment of the population undergoing gastroscopy in an endemic urban region.

Methodology: Over a 12-month period, data were collected from the first consecutive 1000 patients (500 from university hospital, 500 from community hospital) who had gastroscopy and HP evaluation. Read More

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http://dx.doi.org/10.3855/jidc.11877DOI Listing

Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.

Eur J Endocrinol 2020 May;182(5):473-480

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Objective: Co-aggregation of autoimmune diseases is common, suggesting partly shared etiologies. Genetic factors are believed to be important, but objective measures of environmental vs heritable influences on co-aggregation are absent. With a novel approach to twin studies, we aimed at estimating heritability and genetic overlap in seven organ-specific autoimmune diseases. Read More

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http://dx.doi.org/10.1530/EJE-20-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182094PMC

Use of endoscopic assessment of gastric atrophy for gastric cancer risk stratification to reduce the need for gastric mapping.

Scand J Gastroenterol 2020 Apr 28;55(4):402-407. Epub 2020 Mar 28.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Stratification for gastric cancer risk typically involves histologic grading of gastric biopsies. This study aimed to compare endoscopic assessment of gastric atrophy and histologic gastric mapping for gastric cancer risk stratification in a region with relatively high risk of gastric cancer. Endoscopic and histologic gastric cancer risk stratification were compared in Vietnamese patients with functional dyspepsia. Read More

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http://dx.doi.org/10.1080/00365521.2020.1740777DOI Listing
April 2020
2.329 Impact Factor

[Research advances in autoimmune gastritis].

Authors:
Z Yin M Qi Q Wang

Zhonghua Nei Ke Za Zhi 2020 Apr;59(4):322-325

Department of Gastroenterology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China.

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http://dx.doi.org/10.3760/cma.j.cn112138-20190616-00416DOI Listing

Association between gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population.

World J Gastrointest Oncol 2020 Mar;12(3):289-300

Department of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, Shaanxi Province, China.

Background: The single nucleotide polymorphisms of interleukin-21 () gene were confirmed to be related to various diseases, but no studies have examined the possible role of single nucleotide polymorphisms (SNPs) (rs907715, rs2221903, and rs12508721) in gastric precancerous lesions.

Aim: To explore the associations between SNPs of gene (rs907715, rs2221903, and rs12508721) and gastric precancerous lesions in a Chinese population.

Methods: Three SNPs of were genotyped using polymerase chain reaction-ligase detection reaction in 588 cases and 290 healthy controls from May 2013 to December 2016 in northwestern China. Read More

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http://dx.doi.org/10.4251/wjgo.v12.i3.289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081108PMC

PGC-MG7 combination could be used as a follow-up panel for monitoring dynamical progression of gastric precancerous diseases.

Chin J Cancer Res 2020 Feb;32(1):89-95

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China.

Objective: The aim of this study was to investigate the value of the combined expression of the gastric mucosal differentiation protein pepsinogen C (PGC) and gastric cancer (GC)-associated antigen MG7 for the diagnosis of GC and prediction of the development from precancerous conditions to GC.

Methods: The gastric mucosal biopsies of 285 subjects enrolled from a region with a high incidence of GC were obtained and histopathologically examined. Subjects testing negative for GC (n=208) were followed up from 1998 to 2015. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072012PMC
February 2020

Quantitative Diagnosis of Atrophic Gastritis by Probe-Based Confocal Laser Endomicroscopy.

Biomed Res Int 2020 2;2020:9847591. Epub 2020 Mar 2.

Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Aims: The aims of this study were to characterize nonatrophic and atrophic gastric mucosa under conventional endoscopy and probe-based confocal laser endomicroscopy (pCLE) modes and to define quantitative diagnostic parameters for these lesions under pCLE.

Method: In phase I, 64 patients with gastric mucosal lesions diagnosed by gastrointestinal endoscopy were enrolled in the study. Normal mucosa and suspicious lesions were evaluated under normal white light imaging (WLI) and pCLE mode. Read More

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http://dx.doi.org/10.1155/2020/9847591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072097PMC

The Clinical Benefits, Limitations, and Perspectives of the ABC Method.

Intern Med 2020 Mar 19. Epub 2020 Mar 19.

Department of Gastroenterology, Ichikawa General Hospital, Tokyo Dental College, Japan.

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http://dx.doi.org/10.2169/internalmedicine.4450-20DOI Listing

Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer.

Intern Med 2020 Mar 19. Epub 2020 Mar 19.

Department of Gastroenterology, Saku Central Hospital Advanced Care Center, Japan.

Objective The aim of the present study was to evaluate the effectiveness and limitations of a serum screening system for predicting the risk of gastric cancer. Methods Serum pepsinogen I (PG I)/pepsinogen II (PG II) and Helicobacter pylori (HP) antibody levels were measured. Subjects were classified into four groupsaccording to their serological status (the ABC classification system). Read More

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http://dx.doi.org/10.2169/internalmedicine.3521-19DOI Listing

Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis.

J Tradit Chin Med 2019 12;39(6):867-874

Department of Internal Medicine of Traditional Chinese Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China.

Objective: To investigate the effectiveness of Banxia Xiexin decoction (BXD) in a rat model of chronic atrophic gastritis (CAG).

Methods: Sixty 6-week-old healthy Wistar rats (30 males, 30 females) were used in the present study. A rat model of CAG was successfully established using the combined active immunization/ethanol/sodium deoxycholate method. Read More

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December 2019

S100A9 as a novel diagnostic and prognostic biomarker in human gastric cancer.

Scand J Gastroenterol 2020 Mar 15;55(3):338-346. Epub 2020 Mar 15.

Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.

The morbidity and mortality of gastric cancer (GC) is high, but there are lack of the biomarkers for early diagnosis and progression of GC. We aimed to identify a novel biomarker for the growth and progression of GC. The Cancer Genome Atlas (TCGA) database including 352 eligible patients was used to screen candidate genes related to the prognosis of GC. Read More

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http://dx.doi.org/10.1080/00365521.2020.1737883DOI Listing

Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats.

Biomed Pharmacother 2020 Jun 13;126:110036. Epub 2020 Mar 13.

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Objectives: Although many studies have examined changes in gut microbiota composition in gastric carcinogenesis to clarify the mechanism of action of anticancer drugs, it is unclear whether animal models of gastric carcinogenesis adequately reflect the disease in humans.

Methods: To address this issue, the present study investigated changes in the gut microbiome profile of a rat model of gastric carcinogenesis established using a combination of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), sodium salicylate, irregular fasting, and ranitidine. The rats were divided into control (Normal), chronic non-atrophic gastritis (CNAG), chronic atrophic gastritis (CAG), precancerous lesion of gastric cancer (PLGC), and gastric cancer (GC) groups according to histopathological features. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110036DOI Listing

High expression of Helicobacter pylori VapD in both the intracellular environment and biopsies from gastric patients with severity.

PLoS One 2020 12;15(3):e0230220. Epub 2020 Mar 12.

Facultad de Medicina, Departamento de Microbiología y Parasitología, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Helicobacter pylori is a Gram-negative bacterium that causes chronic atrophic gastritis and peptic ulcers and it has been associated with the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT). One of the more remarkable characteristics of H. pylori is its ability to survive in the hostile environment of the stomach. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230220PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067408PMC
March 2020
3.234 Impact Factor

Role of Pernicious Anemia in Patients Admitted to Internal Medicine with Vitamin B12 Deficiency and Oral Replacement Therapy as a Treatment Option.

Clin Lab 2020 Mar;66(3)

Background: To determine the role of vitamin B12 deficiency in pernicious anemia and the efficacy of oral vitamin B12 replacement therapy given regardless of the etiology, and to compare the endoscopic and pathological findings in patients diagnosed with vitamin B12 deficiency.

Methods: The study included 216 patients, aged 18 - 65 years, diagnosed with vitamin B12 level < 200 pg/mL between May 2015 and May 2016. Evaluation was made of the demographic characteristics of the patients, diseases, drugs used, dietary habits, previous use of vitamin B12 replacement therapy, family history of vitamin B12 deficiency, laboratory test values, and neurological symptoms present at the time of presentation. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190809DOI Listing

Prevalence of atrophic gastritis in southwest China and predictive strength of serum gastrin-17: A cross-sectional study (SIGES).

Sci Rep 2020 Mar 11;10(1):4523. Epub 2020 Mar 11.

Department of Gastrointestinal Surgery & Laboratory of Gastric Cancer, West China Hospital, Sichuan University, Chengdu, China.

A hospital-based cross-sectional study in SIGES project was conducted during 2016.5-2017.5 in West China Hospital. Read More

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http://dx.doi.org/10.1038/s41598-020-61472-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066171PMC

Gastric neoplasms in familial adenomatous polyposis: Follow-up strategy for patients with or without atrophic gastritis.

Dig Endosc 2020 May 20;32(4):532-533. Epub 2020 Apr 20.

Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.

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http://dx.doi.org/10.1111/den.13668DOI Listing

Precancerous Gastric Lesions with /2/ Genotype Increase the Risk of Gastric Cancer.

Biomed Res Int 2020 18;2020:7243029. Epub 2020 Feb 18.

School of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

Objective: The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of (), host genetic susceptibility, and host immune responses. This study investigated the presence of , , 2, 2, and genes and their association with clinical outcomes.

Methods: Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. Read More

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http://dx.doi.org/10.1155/2020/7243029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049835PMC
February 2020

Every Fifth Individual With Type 1 Diabetes Suffers From an Additional Autoimmune Disease: A Finnish Nationwide Study.

Diabetes Care 2020 May 5;43(5):1041-1047. Epub 2020 Mar 5.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.

Objective: The aim of this study was to quantify the excess risk of autoimmune hypothyroidism and hyperthyroidism, Addison disease, celiac disease, and atrophic gastritis in adults with type 1 diabetes (T1D) compared with nondiabetic individuals in Finland.

Research Design And Methods: The study included 4,758 individuals with T1D from the Finnish Diabetic Nephropathy (FinnDiane) Study and 12,710 nondiabetic control individuals. The autoimmune diseases (ADs) were identified by linking the data with the Finnish nationwide health registries from 1970 to 2015. Read More

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http://dx.doi.org/10.2337/dc19-2429DOI Listing

Urinary metabolomics research for Huangqi Jianzhong Tang against chronic atrophic gastritis rats based on H NMR and UPLC-Q/TOF MS.

J Pharm Pharmacol 2020 May 3;72(5):748-760. Epub 2020 Mar 3.

Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.

Objectives: As a traditional Chinese medicine (TCM), Huangqi Jianzhong Tang (HQJZ) has a good efficacy in treating chronic atrophic gastritis (CAG). Our objective was to determine its mechanism based on the urine comprehensive metabolome.

Methods: In the study, a metabolomic approach was applied to reveal the efficacy of HQJZ on the constructed CAG rats coupled with proton nuclear magnetic resonance ( H NMR) and ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF MS). Read More

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http://dx.doi.org/10.1111/jphp.13242DOI Listing

Clinicopathological features, risk of lymph node metastasis and survival outcome of synchronous multiple early gastric cancer.

Clin Res Hepatol Gastroenterol 2020 Feb 28. Epub 2020 Feb 28.

Department of Surgical Oncology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, 110001 Shenyang, PR China. Electronic address:

Objective: To determine clinicopathological features, risk of lymph node metastasis (LNM) and survival outcome in synchronous multiple early gastric cancer (MEGC) patients.

Methods: A total of 338 solitary early gastric cancer (SEGC) and 26 MEGC patients who underwent surgical resection were retrospectively reviewed. The clinicopathological features and predictive factors for MEGC patients were evaluated. Read More

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http://dx.doi.org/10.1016/j.clinre.2020.02.004DOI Listing
February 2020

Analysis of clinical characteristics of 2243 with positive anti-gastric parietal cell antibody.

J Clin Lab Anal 2020 Feb 28:e23264. Epub 2020 Feb 28.

Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding, China.

Background: To facilitate the early detection of chronic diseases, we analyzed the clinical characteristics of anti-gastric parietal cell antibody (PCA)-positive population, revealed the early characteristics of the population.

Methods: According to the retrospective analysis, current situation investigation and comparative analysis of the clinical characteristics and medical history of the subjects, the comparison between the groups was performed.

Result: (a) The positive rate of PCA detection in department of gastroenterology in our hospital was 35. Read More

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http://dx.doi.org/10.1002/jcla.23264DOI Listing
February 2020

Therapeutic assessment of fractions of Gastrodiae Rhizoma on chronic atrophic gastritis by H NMR-based metabolomics.

J Ethnopharmacol 2020 May 25;254:112403. Epub 2020 Feb 25.

Center of Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing, 210094, China. Electronic address:

Ethnopharmacological Relevance: Gastrodiae Rhizoma (GR), a well-known and commonly-used TCM (Traditional Chinese Medicine) for treating headache, dizziness, tetanus, epilepsy, and etc., has been proven to relieve chronic atrophic gastritis (CAG). Due to its complex ingredients, the active fractions responsible for the treatment of CAG remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112403DOI Listing

Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer.

Evid Based Complement Alternat Med 2020 12;2020:2869138. Epub 2020 Feb 12.

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.

Gastric cancer (GC) is a highly invasive and fatal malignant disease that accounts for 5.7% of new global cancer cases and is the third leading cause of cancer-related death. Acid/base homeostasis is critical for organisms because protein and enzyme function, cellular structure, and plasma membrane permeability change with pH. Read More

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http://dx.doi.org/10.1155/2020/2869138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040404PMC
February 2020

Screening, Monitoring, and Treatment of Precancerous Atrophic Gastritis in the Prospective Study for Seven Years.

Asian Pac J Cancer Prev 2020 Feb 1;21(2):331-336. Epub 2020 Feb 1.

Department of Software Development, Department of Mathematics, Institute of Applied Mathematics and Information Technology, North Caucasus State Academy for Humanities and Technologies, Cherkessk, Stavropolskaya Street 36, Russian Federation.

Aim: Develop a program to identify, treat, and prevent severe atrophic gastritis to reduce gastric cancer incidence and mortality.

Materials And Methods: In total, 2,847 people aged > 40 years old underwent serological noninvasive screening for atrophic gastritis by identifying postprandial gastrin-17 and pepsinogen-1 in the fasting state. Anti-H pylori IgG was found in 2,134 patients. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.2.331DOI Listing
February 2020

Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis through IRF8-IFN-γ signaling axis suppressing.

Life Sci 2020 May 22;248:117456. Epub 2020 Feb 22.

Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing 100039, PR China. Electronic address:

Aims: In this study, we will investigate the therapeutic effects of berberine (BBR) in Helicobacter pylori (H. pylori) induced chronic atrophic gastritis (CAG). Furthermore, potential mechanisms of BBR in regulating IRF8-IFN-γ signaling axis will also be investigated. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117456DOI Listing

Diagnosing chronic atrophic gastritis by gastroscopy using artificial intelligence.

Dig Liver Dis 2020 May 13;52(5):566-572. Epub 2020 Feb 13.

School of Computer Science and Technology, Xidian University, Xi'an, China.

Background: The sensitivity of endoscopy in diagnosing chronic atrophic gastritis is only 42%, and multipoint biopsy, despite being more accurate, is not always available.

Aims: This study aimed to construct a convolutional neural network to improve the diagnostic rate of chronic atrophic gastritis.

Methods: We collected 5470 images of the gastric antrums of 1699 patients and labeled them with their pathological findings. Read More

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http://dx.doi.org/10.1016/j.dld.2019.12.146DOI Listing

Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients.

Sci Rep 2020 Feb 13;10(1):2582. Epub 2020 Feb 13.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; National Clinical Research Center for Digestive Diseases; Beijing Digestive Disease Center; Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China.

Gastric hyperplastic polyps (GHPs) have a potential risk of neoplastic transformation, but the responsible mechanisms have not yet been established. We conducted a study involving 55 patients (33 female) who had undergone endoscopic or surgical resection of GHPs. We compared 16 patients who had GHPs showing neoplastic transformation with 39 patients who had non-neoplastic GHPs. Read More

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http://dx.doi.org/10.1038/s41598-020-58900-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018716PMC
February 2020

Atrophic enteropathy refractory to a gluten-free diet: what should we consider?

Rev Esp Enferm Dig 2020 Apr;112(4):328-329

Aparato Digestivo, Hospital Virgen de Altagracia.

Olmesartan is an angiotensin II receptor antagonist used for the treatment of blood hypertension. Long-term use has been associated with diarrhea and sometimes intestinal involvement may mimic enteropathies such as celiac disease. Clinicians should consider drugs within the differential diagnosis of enteropathies. Read More

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http://dx.doi.org/10.17235/reed.2020.6361/2019DOI Listing