5,056 results match your criteria Gastritis Atrophic


Non-malignant Helicobacter pylori-Associated Diseases.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Helicobacter pylori infection of the human stomach is associated with chronic gastritis, peptic ulcer disease or gastric carcinoma, and thus a high burden for the public health systems worldwide. Fortunately, only a small subfraction of up to 15-20% of infected individuals will develop serious complications. Unfortunately, it is not always known upfront, who will be affected by serious diesease outcome. Read More

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http://dx.doi.org/10.1007/5584_2019_362DOI Listing

Unusual histopathologic features in thymic corpuscles associated with porcine periweaning failure-to-thrive syndrome.

J Vet Diagn Invest 2019 Apr 22:1040638719846208. Epub 2019 Apr 22.

Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain.

Six, 5-6-wk-old pigs, from 3 farms of the same company, with significant loss of body condition were submitted for postmortem evaluation. Macroscopically, the main lesion observed in all of the pigs was thymic atrophy. Microscopically, all of the pigs had thymic atrophy, superficial lymphocytic fundic gastritis, atrophic enteritis, superficial colitis, and neutrophilic and lymphocytic rhinitis, leading to a diagnosis of porcine periweaning failure-to-thrive syndrome. Read More

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http://dx.doi.org/10.1177/1040638719846208DOI Listing

Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis.

Pharmacol Res 2019 Apr 13;144:158-166. Epub 2019 Apr 13.

Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Chronic atrophic gastritis (CAG) is a common digestive disease without specific treatment. According to syndrome differentiation, traditional Chinese medicine (TCM) classified it into different syndromes and has achieved significant therapeutic effects. In this study, immune repertoire sequencing techniques combined with symptom scores, electronic gastroscopy as well as pathologic changes were used to evaluate the effect and the underlying mechanism of Modified Sijunzi Decoction (MSD) in treating CAG. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.012DOI Listing
April 2019
1 Read

Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study.

Sci Rep 2019 Apr 15;9(1):6099. Epub 2019 Apr 15.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Helicobacter pylori (H. pylori), an established risk factor for gastric cancer, is suggested to also play a role in the development of pancreatic cancer; however, the association remains inconclusive. We examined this association among Japanese men and women. Read More

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http://dx.doi.org/10.1038/s41598-019-42365-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465350PMC
April 2019
1 Read

Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Gastric cancer is the third leading cause of cancer mortality worldwide. Studies investigating the effect of salt on gastric cancer have mainly used self-reported measures, which are not as accurate as sodium/creatinine ratios because individuals may not know the amount of salt in their food. Using data from a prospective cohort study, we investigated the effect of salt intake on progression to gastric precancerous lesions. Read More

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http://dx.doi.org/10.3390/cancers11040467DOI Listing
April 2019
1 Read

Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer.

World J Gastroenterol 2019 Apr;25(13):1580-1591

The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Background: Early gastric cancer (EGC), compared with advanced gastric cancer (AGC), has a higher 5-year survival rate. However, due to the lack of typical symptoms and the difficulty in diagnosing EGC, no effective biomarkers exist for the detection of EGC, and gastroscopy is the only detection method.

Aim: To provide new biomarkers with high specificity and sensitivity through analyzed the differentially expressed microRNAs (miRNAs) in EGC and AGC and compared them with those in benign gastritis (BG). Read More

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http://dx.doi.org/10.3748/wjg.v25.i13.1580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452233PMC
April 2019
1 Read
2.369 Impact Factor

Evaluating the Accuracy of the Endoscopic ABC Classification System in Diagnosing Helicobacter pylori-Infected Gastritis.

Digestion 2019 Apr 12:1-10. Epub 2019 Apr 12.

Department of General Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Aims: Evaluating the accuracy of the modified Endoscopic ABC (Endo ABC) classification with an electronic endoscopy with narrow band imaging without magnification in diagnosing Helicobacter pylori (H. pylori)-infected gastritis.

Methods: A total of 576 patients were enrolled and they underwent modified Endo ABC. Read More

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http://dx.doi.org/10.1159/000498966DOI Listing

Effect of Citric Acid on Accuracy of C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis.

Gut Liver 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background/aims: : The validity of C-urea breath test (CUBT) for detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of C-Urea breath test after eradication therapy in a region where atrophic gastritis is common.

Materials: : In this prospective study, -positive patients received C-UBT after eradication regimen. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18398DOI Listing
April 2019
5 Reads
1.494 Impact Factor

The relationship between gastric microbiota and gastric disease.

Scand J Gastroenterol 2019 Apr 4:1-6. Epub 2019 Apr 4.

a Endoscopy Center, Tianjin Union Medical Center , Tianjin , China.

Traditionally, the stomach was believed to be a sterile organ unsuitable for microbiota growth. However, the discovery of H. pylori subverted this conception. Read More

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http://dx.doi.org/10.1080/00365521.2019.1591499DOI Listing
April 2019
4 Reads

[Effect of moxibustion at "Zusanli"(ST36) on metabolites of gastric tissue in rats with chronic atrophic gastritis based on metabonomics].

Zhen Ci Yan Jiu 2019 Feb;44(2):113-9

College of Acupuncture-moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha 410208, China.

Objective: To observe the effect of moxibustion at "Zusanli" (ST36) on metabolites of gastric tissue in chronic atrophic gastritis (CAG) rats, so as to explore the correlation between Yangming Meridian and stomach based on metabolomics.

Methods: Fifty-six SD rats were randomly divided into normal, normal + moxibustion, model and model + moxibustion groups (=14 rats/group). The CAG model was established by gavage of N-methyl-N'-nitro-N-nitroso-guanidine (MNNG) solution and irregular diet for 12 weeks. Read More

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http://www.cnki.net/kcms/doi/10.13702/j.1000-0607.180149.htm
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http://dx.doi.org/10.13702/j.1000-0607.180149DOI Listing
February 2019
8 Reads

Role of Upper Gastrointestinal Endoscopy in Patients with Human Immunodeficiency Virus Infection in the Era of Combination Antiretroviral Therapy.

Infect Chemother 2019 Mar;51(1):35-44

Division of Infectious Diseases, Department of Internal Medicine, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Korea.

Background: Gastrointestinal (GI) diseases are common in patients with human immunodeficiency virus (HIV) infection. There are few reports on the epidemiology and endoscopic findings of gastric cancer in patients with HIV infection in the era of combination antiretroviral therapy (cART). We retrospectively analyzed upper GI endoscopic findings in patients with HIV infection and investigated their role as gastric cancer screening. Read More

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http://dx.doi.org/10.3947/ic.2019.51.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446010PMC
March 2019
2 Reads

Clinicopathological features of duodenal bulb biopsies and their relationship with upper gastrointestinal diseases.

Ann Diagn Pathol 2019 Feb 10;40:40-44. Epub 2019 Feb 10.

Department of Gastroenterology, Peking University Third Hospital, 49 Rd. Garden, Haidian District, Beijing, PR China.

Aim: To assess the prevalence of the lesions in duodenal bulb mucosa and the relationship between duodenal lesions and upper gastrointestinal diseases, including helicobacter pylori infection.

Methods: Clinical, endoscopic and pathological data of the cases with duodenal bulb and gastric mucosal biopsy from January 2005 to May 2017 were analyzed retrospectively.

Results: A total of 3540 patients were enrolled. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.006DOI Listing
February 2019
2 Reads

Association of genetic polymorphisms in with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.

Oncol Lett 2019 Mar 18;17(3):3482-3488. Epub 2019 Jan 18.

Department of Gastroenterology, Kanazawa Medical University, Uchinada-machi, Ishikawa 920-0293, Japan.

The aim of the present study was to investigate whether single nucleotide polymorphisms in the gene are associated with susceptibility to gastric cancer in the Japanese population. The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Read More

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http://dx.doi.org/10.3892/ol.2019.9948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396126PMC
March 2019
3 Reads
0.987 Impact Factor

Diagnostic value of apolipoprotein C-I, transthyretin and apolipoprotein C-III in gastric cancer.

Oncol Lett 2019 Mar 22;17(3):3227-3232. Epub 2019 Jan 22.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China.

Diagnostic value of apolipoprotein C-I (ApoC-I), transthyretin (TTR) and ApoC-III in gastric cancer were evaluated. Retrospective analysis methods were used to collect 60 patients with gastric cancer first diagnosed in The First Affiliated Hospital of Jiaxing University. There were 60 patients with chronic atrophic gastritis in the benign lesion group and 60 healthy individuals in the control group. Read More

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http://dx.doi.org/10.3892/ol.2019.9957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396204PMC
March 2019
5 Reads

Epidemiology of Sulcascaris sulcata (Nematoda: Anisakidae) ulcerous gastritis in the Mediterranean loggerhead sea turtle (Caretta caretta).

Parasitol Res 2019 May 11;118(5):1457-1463. Epub 2019 Mar 11.

Department of Animal Medicine, Production and Health, University of Padova, 35020, Legnaro, Italy.

Sulcascaris sulcata Rudolphi 1819 is a gastric nematode parasite of sea turtles. Here, we report the occurrence and describe for the first time the pathological changes caused by S. sulcata in the Mediterranean loggerhead sea turtle (Caretta caretta) stranded along the Tyrrhenian coast and northern Adriatic coast of Italy. Read More

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http://dx.doi.org/10.1007/s00436-019-06283-0DOI Listing
May 2019
2.327 Impact Factor

Risk Factors of Lymph Node Metastasis in Patients with Early Pure and Mixed Signet Ring Cell Gastric Carcinomas.

J Cancer 2019 29;10(5):1124-1131. Epub 2019 Jan 29.

Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly investigated. The aim of this study was to identify risk factors of LNM and compare clinicopathological characteristics and prognosis of early gastric pSRCC with mSRCC. Read More

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http://dx.doi.org/10.7150/jca.29245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400689PMC
January 2019
1 Read

GastroPanel® Biomarker Assay: The Most Comprehensive Test for Infection and Its Clinical Sequelae. A Critical Review.

Anticancer Res 2019 Mar;39(3):1091-1104

Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, P.R. China.

Background/aim: Several clinical conditions seriously hamper the diagnostic accuracy of the commonly used tests for Helicobacter pylori (Hp), C-urea breath test (UBT) and stool antigen test (SAT). The present communication is a critical review of the potential limitations of UBT and SAT, and describes the approach on how these can be avoided. Drawbacks of the Hp tests: False-negative results are most often due to low bacterial load in the stomach due to: i) use of proton pump inhibitor medication; ii) use of antibiotics; iii) presence of atrophic gastritis and hypoacid stomach; iv); bleeding peptic ulcer; v) gastric cancer (GC) and vi) mucosal-associated lymphatic tissue lymphoma. Read More

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http://dx.doi.org/10.21873/anticanres.13218DOI Listing
March 2019
2 Reads

Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019.

Endoscopy 2019 Apr 6;51(4):365-388. Epub 2019 Mar 6.

Gastroenterology Department, Portuguese Oncology Institute of Porto, Portugal.

Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric adenocarcinoma. This underscores the importance of diagnosis and risk stratification for these patients. High definition endoscopy with chromoendoscopy (CE) is better than high definition white-light endoscopy alone for this purpose. Read More

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http://dx.doi.org/10.1055/a-0859-1883DOI Listing
April 2019
3 Reads

Chemoprevention of gastric cancer by Helicobacter pylori eradication and its underlying mechanism.

Authors:
Nayoung Kim

J Gastroenterol Hepatol 2019 Mar 3. Epub 2019 Mar 3.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

The cascade of gastric cancer, a leading cause of cancer incidence and mortality, is multifactorial. Helicobacter pylori (HP) infection plays a major role in gastric cancer (GC), and there has been an accumulation of data regarding the chemopreventive effect of HP eradication. However, it remains unclear how HP infection causes GC and how HP eradication prevents GC. Read More

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http://doi.wiley.com/10.1111/jgh.14646
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http://dx.doi.org/10.1111/jgh.14646DOI Listing
March 2019
10 Reads
3.504 Impact Factor

Eradication of Helicobacter pylori in a Living Donor Liver Transplant Recipient With Immunosuppressive Therapy of Cyclosporine A: A Case Report.

Transplant Proc 2019 Apr 9;51(3):1006-1007. Epub 2019 Jan 9.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

A 54-year-old woman underwent living donor liver transplantation (LDLT) for primary biliary cholangitis (PBC) three years earlier. She took cyclosporine A (CyA) 150 mg/day as immunosuppression for prevention of rejection and PBC recurrence. Routine upper gastrointestinal endoscopy showed chronic atrophic gastritis and hyperplastic polyp, and rapid urease test was positive. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.028DOI Listing
April 2019
1 Read

Association of increased B7 protein expression by infiltrating immune cells with progression of gastric carcinogenesis.

Medicine (Baltimore) 2019 Feb;98(8):e14663

Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University Jiangsu Key Laboratory of Clinical Immunology, Soochow University.

B7 negative costimulatory molecules are a group of molecules associated with the occurrence, development, and therapy of cancers. Here, we aimed to determine the clinical significance of PD-L1, B7-H3, and B7-H4 and their expression in CD8 and CD68 positive cells at different stages of gastric carcinogenesis.We detected PD-L1, B7-H3, B7-H4, CD8, and CD68 expression in samples by immunohistochemical staining of 62 chronic superficial gastritis (CSG) samples, 72 chronic atrophic gastritis (CAG) samples, 68 low-grade intraepithelial neoplasia (LIN) samples, 65 high-grade intraepithelial neoplasia (HIN) samples obtained from gastroscopic biopsies and 50 gastric adenocarcinoma (GA) samples obtained from surgical resections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407991PMC
February 2019
4 Reads

Can neopterin be a useful immune biomarker for differentiating gastric intestinal metaplasia and gastric atrophy from non-atrophic non-metaplastic chronic gastritis?

Gastroenterol Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Usak University, Faculty of Medicine, Medical Oncology Department, Turkey.

Introduction: Helicobacter pylori (H. pylori) is closely related to pre-neoplastic lesions such as gastric atrophy (GA), gastric intestinal metaplasia (GIM) and eventually gastric cancer (GC). The diagnosis of GIM and GA is usually based on endoscopic and histopathological features. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2019.01.005DOI Listing
February 2019
3 Reads

The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal.

Expert Rev Gastroenterol Hepatol 2019 Jan 13;13(1):17-24. Epub 2018 Nov 13.

f Department of Medicine , Michael E. DeBakey VA Medical Center, and Baylor College of Medicine , Houston , TX , USA.

Introduction: Gastric cancer is one of the top causes of cancer-related death worldwide. How to eliminate gastric cancer is an urgent public-health issue. Areas covered: In this review, we present up-to-date results of studies on gastric cancer prevention through the eradication of Helicobacter pylori and discuss strategies and obstacles for the implementation of population-wide screening and treatment of this pathogen to prevent gastric cancer. Read More

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http://dx.doi.org/10.1080/17474124.2019.1542299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391731PMC
January 2019
2 Reads

Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging.

Helicobacter 2019 Apr 17;24(2):e12571. Epub 2019 Feb 17.

Department of Translational Research and of New Surgical and Medical Technologies, Pathology Section, University of Pisa, Pisa, Italy.

Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy. Helicobacter pylori (H. pylori) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized H. Read More

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http://dx.doi.org/10.1111/hel.12571DOI Listing

Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 04 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
April 2019
6 Reads

Pathologic findings of the removed stomach during sleeve gastrectomy.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL, USA.

Background: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. Read More

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http://dx.doi.org/10.1007/s00464-019-06689-yDOI Listing
February 2019
2 Reads

Helicobacter pylori and nutrition: a bidirectional communication.

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Unit of Dietetics and Clinical Nutrition, Città della Salute e della Scienza, Turin, Italy.

Helicobacter pylori (HP) is a gram negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02568-6DOI Listing
February 2019
9 Reads

Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats.

Med Sci Monit 2019 Feb 13;25:1177-1186. Epub 2019 Feb 13.

External Liaison Office, Second Affiliated Hospital of Nanjing University of Chinese Medicine (Second Hospital of Jiangsu Province), Nanjing, Jiangsu, China (mainland).

BACKGROUND This study investigated the effect and mechanism of notoginsenoside R1 (NGR1) on chronic atrophic gastritis (CAG) in a rat model. MATERIAL AND METHODS To perform our investigation, a rat model of CAG was established, and then rats were treated with various doses of NGR1. After treatment, hematoxylin-eosin (HE) staining was used for histopathological observation and further scoring. Read More

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http://dx.doi.org/10.12659/MSM.911512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381808PMC
February 2019
5 Reads

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Apr;114(4):648-655

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
April 2019
3 Reads

Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.

Front Neurosci 2019 25;13. Epub 2019 Jan 25.

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.

Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Read More

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http://dx.doi.org/10.3389/fnins.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355687PMC
January 2019
2 Reads

Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.

J Formos Med Assoc 2019 Feb 5. Epub 2019 Feb 5.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.016DOI Listing
February 2019
2 Reads

Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs.

BMC Cancer 2019 Feb 8;19(1):129. Epub 2019 Feb 8.

Guangzhou University of Chinese Medicine, No.12 Jichang Road, Guangzhou, 510405, Guangdong Province, China.

Background: Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined as precancrerous lesions of GC remain largely elusive. To investigate serum exosomal miRNAs that are differently expressed in CAG patients and Chronic nonatrophic gastritis (CNAG) may be helpful for its diagnosis and therapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368711PMC
February 2019
5 Reads

Effect of Age on Effectiveness of Vonoprazan in Triple Therapy for Helicobacter pylori Eradication.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Japan.

Objective We evaluated the efficacy of vonoprazan-based eradication therapy for Helicobacter pylori, including the effects of age, gender, and grade of atrophy in comparison to proton pump inhibitor-based therapy. Method We retrospectively reviewed the records of 1172 patients who received first-line triple therapy with amoxicillin, clarithromycin, and a proton pump inhibitor or vonoprazan for H. pylori eradication, as well as 157 patients treated with second-line therapy consisting of amoxicillin, metronidazole, and vonoprazan or a PPI. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2233-18DOI Listing
February 2019
6 Reads

Changes in the indices of prooxidant and antioxidant systems in blood plasma in men with atrophic gastritis and gastric cancer.

Ter Arkh 2018 Feb;90(2):24-27

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division "Scientific Research Institute of medical problems of the North" (SRI MPN), Krasnoyarsk, Russia.

Aim: To study changes in the indices of prooxidant and antioxidant systems in plasma in men with atrophic gastritis and gastric cancer.

Materials And Methods: The study included 60 healthy men, 42 patients with atrophic gastritis and 50 men, nicardipine patients with gastric cancer stage II according to TNM. All patients underwent serological diagnosis of diffuse atrophic gastritis (definition of pepsinogens and gas- trin-17) and Helicobacter pylori infection. Read More

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http://dx.doi.org/10.26442/terarkh201890224-27DOI Listing
February 2018
2 Reads

Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study.

BMJ Open 2019 Jan 29;9(1):e024689. Epub 2019 Jan 29.

Braun School of Public Health and Community Medicine, Hebrew University-Hadassah, Jerusalem, Israel.

Objective: Understanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence.

Methods: In a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland), serum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25-78 years, randomly selected from Israel's population registry in age-sex and population strata. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352795PMC
January 2019
7 Reads

Body Mass Index and Risk of Intestinal Metaplasia: A Cohort Study.

Cancer Epidemiol Biomarkers Prev 2019 Apr 30;28(4):789-797. Epub 2019 Jan 30.

Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia.

Methods: This retrospective cohort study included 142,832 Korean adults free of endoscopic intestinal metaplasia and atrophic gastritis who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted HR with 95% confidence interval (CI) for incident intestinal metaplasia. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0733DOI Listing
April 2019
1 Read

Long-term gastric cancer risk in male smokers with atrophic corpus gastritis.

Scand J Gastroenterol 2019 Jan 31:1-7. Epub 2019 Jan 31.

a Department of Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Objectives: The aim of this study was to evaluate long-term gastric cancer risk in male smokers with and without atrophic gastritis.

Materials And Methods: A total of 22,346 elderly male smokers participated in the Helsinki Gastritis Study between the years 1989 and 1993. Serum pepsinogen I (PGI) was measured for the men, and 2,132 men with low PGI (<25 µg/L; a marker of atrophic corpus gastritis) were invited to undergo gastroscopy because of increased gastric cancer risk. Read More

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http://dx.doi.org/10.1080/00365521.2019.1566492DOI Listing
January 2019
1 Read

KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran.

Iran J Pathol 2018 17;13(2):167-172. Epub 2018 Jul 17.

Dept. of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background & Objective: mutations are reported in many types of cancers including pancreas, lung, colon, breast,and gastric (GC). High frequency of mutation is observed in the pancreas,colon, and lung cancers; they commonly arise in codon 12 and 13 of exon 2. Due to the lack of information about the frequency of mutations in the Northeast of Iran, the currentstudy aimed at evaluating frequency in cases with GC in this region. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339504PMC
July 2018
1 Read

NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production.

World J Gastroenterol 2019 Jan;25(3):330-345

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea.

Background: Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343100PMC
January 2019
3 Reads

Gastric carcinoids: Does type of surgery or tumor affect survival?

Am J Surg 2019 May 28;217(5):937-942. Epub 2018 Dec 28.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA. Electronic address:

Background: Gastric carcinoids are rare neuroendocrine tumors of the gastrointestinal tract. They are typically managed according to their etiology. However, there is little known about the impact of surgical strategy on the long-term outcomes of these patients. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.12.057DOI Listing
May 2019
2 Reads

Diagnostic performance of serum pepsinogen assay for the prediction of atrophic gastritis and gastric neoplasms: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14240

Department of Internal Medicine.

Background: Serum pepsinogen assay (sPGA) combining concentration of pepsinogen I (PG I), and the ratio of PG I/II is the noninvasive biomarker for predicting chronic atrophic gastritis (CAG) and neoplasms reflecting mucosal secretory status. Although various cut-off values have been suggested, PG I ≤70 ng/mL and PG I/II ≤3 have been widely accepted. However, previous studies for diagnostic test accuracy presented only pooled outcomes, which cannot discriminate the diagnostic validity of sPGA with cut-off of PG I ≤70 ng/mL and PG I/II ≤3. Read More

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http://dx.doi.org/10.1097/MD.0000000000014240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358409PMC
January 2019
4 Reads
5.723 Impact Factor

Virulence factor genotyping of Helicobacter pylori isolated from Costa Rican dyspeptic patients.

Microb Pathog 2019 Mar 14;128:276-280. Epub 2019 Jan 14.

Institute for Health Research (INISA), University of Costa Rica, San Pedro, 11501, San José, Costa Rica. Electronic address:

Background And Aims: Costa Rica is one of the countries with the highest incidence and mortality rates for gastric cancer. Helicobacter pylori infection rates are high in the whole country. We have previously shown that H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183095
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http://dx.doi.org/10.1016/j.micpath.2019.01.018DOI Listing
March 2019
12 Reads
2.000 Impact Factor

The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective.

Autoimmun Rev 2019 Mar 11;18(3):215-222. Epub 2019 Jan 11.

Division of Gastroenterology and Center for Autoimmune Liver Diseases, ASST San Gerardo Hospital, Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.

Chronic autoimmune atrophic gastritis (CAAG) is an organ-specific autoimmune disease, which affects the corpus-fundus gastric mucosa. Although it has been described for several years, the real pathophysiological mechanisms, the natural history and the possible neoplastic complications are not completely known. Atrophy of the gastric mucosa is the endpoint of the chronic processes, with the loss of glandular cells and their replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.08.011DOI Listing
March 2019
7 Reads

Gastroesophageal reflux symptoms and microscopic esophagitis in a cohort of consecutive patients affected by atrophic body gastritis: a pilot study.

Scand J Gastroenterol 2019 Jan 13;54(1):35-40. Epub 2019 Jan 13.

a Medical-Surgical Department of Clinical Sciences and Translational Medicine , University Sapienza , Roma , Italy.

Aim: In patients affected by atrophic body gastritis (ABG) gastro-oesophageal reflux (GER) related symptoms have been reported, despite the presence of hypochlorhydria.

Objective: Objectives of this single-centre study was to assess in ABG the occurrence of GER-related symptoms and their relationship with histopathologic oesophageal findings.

Materials And Methods: Fifty-four consecutive patients (20. Read More

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http://dx.doi.org/10.1080/00365521.2018.1553062DOI Listing
January 2019
6 Reads

HOX transcript antisense RNA is elevated in gastric carcinogenesis and regulated by the NF-κB pathway.

J Cell Biochem 2019 Jun 11;120(6):10548-10555. Epub 2019 Jan 11.

Department of Medical Microbiology, School of Basic Medical Science, Shandong University, Jinan, Shandong, China.

The expression pattern of HOX transcript antisense RNA (HOTAIR) in the progression of gastric cancer and the regulation of its expression are still unclear. In the current study, HOTAIR expressions in gastric tissues collected from patients with superficial gastritis, atrophic gastritis, atypical hyperplasia, and gastric cancer as well as normal controls was quantitatively examined. The results showed that the expression of HOTAIR was higher in gastric cancer than in normal tissues, but reached the highest level in atrophic gastritis, suggesting that HOTAIR may be involved in the molecular process of nonresolving inflammation. Read More

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http://dx.doi.org/10.1002/jcb.28340DOI Listing
June 2019
3 Reads

MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia.

Gut 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background And Aims: Gastric intestinal metaplasia (IM) is common in the gastric epithelium of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile acids and following chronic inflammation. But the mechanism underlying how bile acids activate CDX2 in gastric epithelium has not been fully explored. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315318
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http://dx.doi.org/10.1136/gutjnl-2017-315318DOI Listing
January 2019
7 Reads
14.660 Impact Factor

The incidence of neoplasia in patients with autoimmune metaplastic atrophic gastritis: a renewed call for surveillance.

Ann Gastroenterol 2019 Jan-Feb;32(1):67-72. Epub 2018 Nov 8.

Division of Gastroenterology (Nadim Mahmud, Bryson W. Katona, David C. Metz).

Background: Autoimmune metaplastic atrophic gastritis (AMAG) is an immune-mediated process that may lead to pernicious anemia (PA) and an increased risk of gastric cancer. Although some literature supports 3- or 5-year endoscopic surveillance for gastric cancer in patients with PA, no formal guidance exists for the general AMAG population. We sought to identify the prevalence and incidence rates of dysplasia or adenocarcinoma in patients with AMAG in order to clarify endoscopic best practices. Read More

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http://www.annalsgastro.gr/files/journals/1/earlyview/2018/e
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http://dx.doi.org/10.20524/aog.2018.0325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302190PMC
November 2018
15 Reads

Abnormalities in acute salivary biochemical characteristic responses to gustatory stimulation with citric acid in chronic non-atrophic gastritis.

J Gastroenterol Hepatol 2018 Dec 29. Epub 2018 Dec 29.

Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background And Aim: Salivary characteristics are altered in gastrointestinal diseases and related to oral taste disorder. However, specific salivary biochemical characteristics and their relationships with oral taste disturbances in chronic non-atrophy gastritis (CNAG) remain uncertain.

Methods: Seventy patients with CNAG and 70 subjects in healthy control group (HCG) were enrolled in our study. Read More

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http://dx.doi.org/10.1111/jgh.14587DOI Listing
December 2018
35 Reads

[Impact of Catgut Embedding Intervention on JAK 2-STAT 3 Signaling in Gastric Mucosa of Chronic Atrophic Gastritis Rats].

Zhen Ci Yan Jiu 2018 Nov;43(11):682-6

Foshan Renhe Hospital of Chinese Medicine, Foshan 528000, Guangdong Province.

Objective: To observe the impact of catgut embedding on histopathological changes and expression of phosphorylated-Janus kinase-2 (p-JAK 2), phosphorylated-signal transducer and activator of transcription 3 (p-STAT 3), Cyclin D 1, Bcl-2, and suppressor of cytokine signaling (SOCS) of the gastric mucosa in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improving CAG.

Methods: Forty-one SD rats were randomly divided into normal (=12), model (=9), natural recovery (=10) and catgut embedding (=10) groups. The CAG model was established by free drinking of N-methyl-N'-nitro-N-nitroso-guanidine (MNNG) solution (100µg/mL) and irregular diet for 24 weeks. Read More

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http://dx.doi.org/10.13702/j.1000-0607.180178DOI Listing
November 2018
4 Reads