5,027 results match your criteria Gastritis Atrophic


Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging.

Helicobacter 2019 Feb 17:e12571. Epub 2019 Feb 17.

Department of Translational Research and of New Surgical and Medical Technologies, Pathology Section, University of Pisa, Pisa, Italy.

Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy. Helicobacter pylori (H. pylori) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized H. Read More

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http://dx.doi.org/10.1111/hel.12571DOI Listing
February 2019

Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
February 2019

Pathologic findings of the removed stomach during sleeve gastrectomy.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL, USA.

Background: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. Read More

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http://dx.doi.org/10.1007/s00464-019-06689-yDOI Listing
February 2019

Helicobacter pylori and nutrition: a bidirectional communication.

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Unit of Dietetics and Clinical Nutrition, Città della Salute e della Scienza, Turin, Italy.

Helicobacter pylori (HP) is a gram negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02568-6DOI Listing
February 2019
1 Read

Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats.

Med Sci Monit 2019 Feb 13;25:1177-1186. Epub 2019 Feb 13.

External Liaison Office, Second Affiliated Hospital of Nanjing University of Chinese Medicine (Second Hospital of Jiangsu Province), Nanjing, Jiangsu, China (mainland).

BACKGROUND This study investigated the effect and mechanism of notoginsenoside R1 (NGR1) on chronic atrophic gastritis (CAG) in a rat model. MATERIAL AND METHODS To perform our investigation, a rat model of CAG was established, and then rats were treated with various doses of NGR1. After treatment, hematoxylin-eosin (HE) staining was used for histopathological observation and further scoring. Read More

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http://dx.doi.org/10.12659/MSM.911512DOI Listing
February 2019

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
1 Read

Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.

Front Neurosci 2019 25;13. Epub 2019 Jan 25.

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.

Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Read More

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http://dx.doi.org/10.3389/fnins.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355687PMC
January 2019
1 Read

Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.

J Formos Med Assoc 2019 Feb 5. Epub 2019 Feb 5.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.016DOI Listing
February 2019
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Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs.

BMC Cancer 2019 Feb 8;19(1):129. Epub 2019 Feb 8.

Guangzhou University of Chinese Medicine, No.12 Jichang Road, Guangzhou, 510405, Guangdong Province, China.

Background: Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined as precancrerous lesions of GC remain largely elusive. To investigate serum exosomal miRNAs that are differently expressed in CAG patients and Chronic nonatrophic gastritis (CNAG) may be helpful for its diagnosis and therapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368711PMC
February 2019
2 Reads

Effect of Age on Effectiveness of Vonoprazan in Triple Therapy for Helicobacter pylori Eradication.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Japan.

Objective We evaluated the efficacy of vonoprazan-based eradication therapy for Helicobacter pylori, including the effects of age, gender, and grade of atrophy in comparison to proton pump inhibitor-based therapy. Method We retrospectively reviewed the records of 1172 patients who received first-line triple therapy with amoxicillin, clarithromycin, and a proton pump inhibitor or vonoprazan for H. pylori eradication, as well as 157 patients treated with second-line therapy consisting of amoxicillin, metronidazole, and vonoprazan or a PPI. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2233-18DOI Listing
February 2019
5 Reads

Changes in the indices of prooxidant and antioxidant systems in blood plasma in men with atrophic gastritis and gastric cancer.

Ter Arkh 2018 Feb;90(2):24-27

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division "Scientific Research Institute of medical problems of the North" (SRI MPN), Krasnoyarsk, Russia.

Aim: To study changes in the indices of prooxidant and antioxidant systems in plasma in men with atrophic gastritis and gastric cancer.

Materials And Methods: The study included 60 healthy men, 42 patients with atrophic gastritis and 50 men, nicardipine patients with gastric cancer stage II according to TNM. All patients underwent serological diagnosis of diffuse atrophic gastritis (definition of pepsinogens and gas- trin-17) and Helicobacter pylori infection. Read More

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http://dx.doi.org/10.26442/terarkh201890224-27DOI Listing
February 2018
1 Read

Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study.

BMJ Open 2019 Jan 29;9(1):e024689. Epub 2019 Jan 29.

Braun School of Public Health and Community Medicine, Hebrew University-Hadassah, Jerusalem, Israel.

Objective: Understanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence.

Methods: In a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland), serum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25-78 years, randomly selected from Israel's population registry in age-sex and population strata. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024689DOI Listing
January 2019
1 Read

Body mass index and risk of intestinal metaplasia: A cohort study.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.

Background: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia (IM).

Methods: This retrospective cohort study included 142,832 Korean adults free of endoscopic IM and atrophic gastritis (AG) who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident IM. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0733DOI Listing
January 2019
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Long-term gastric cancer risk in male smokers with atrophic corpus gastritis.

Scand J Gastroenterol 2019 Jan 31:1-7. Epub 2019 Jan 31.

a Department of Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Objectives: The aim of this study was to evaluate long-term gastric cancer risk in male smokers with and without atrophic gastritis.

Materials And Methods: A total of 22,346 elderly male smokers participated in the Helsinki Gastritis Study between the years 1989 and 1993. Serum pepsinogen I (PGI) was measured for the men, and 2,132 men with low PGI (<25 µg/L; a marker of atrophic corpus gastritis) were invited to undergo gastroscopy because of increased gastric cancer risk. Read More

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http://dx.doi.org/10.1080/00365521.2019.1566492DOI Listing
January 2019

KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran.

Iran J Pathol 2018 17;13(2):167-172. Epub 2018 Jul 17.

Dept. of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background & Objective: mutations are reported in many types of cancers including pancreas, lung, colon, breast,and gastric (GC). High frequency of mutation is observed in the pancreas,colon, and lung cancers; they commonly arise in codon 12 and 13 of exon 2. Due to the lack of information about the frequency of mutations in the Northeast of Iran, the currentstudy aimed at evaluating frequency in cases with GC in this region. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339504PMC

NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production.

World J Gastroenterol 2019 Jan;25(3):330-345

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea.

Background: Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343100PMC
January 2019
1 Read

Gastric carcinoids: Does type of surgery or tumor affect survival?

Am J Surg 2018 Dec 28. Epub 2018 Dec 28.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA. Electronic address:

Background: Gastric carcinoids are rare neuroendocrine tumors of the gastrointestinal tract. They are typically managed according to their etiology. However, there is little known about the impact of surgical strategy on the long-term outcomes of these patients. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.12.057DOI Listing
December 2018
1 Read

Diagnostic performance of serum pepsinogen assay for the prediction of atrophic gastritis and gastric neoplasms: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14240

Department of Internal Medicine.

Background: Serum pepsinogen assay (sPGA) combining concentration of pepsinogen I (PG I), and the ratio of PG I/II is the noninvasive biomarker for predicting chronic atrophic gastritis (CAG) and neoplasms reflecting mucosal secretory status. Although various cut-off values have been suggested, PG I ≤70 ng/mL and PG I/II ≤3 have been widely accepted. However, previous studies for diagnostic test accuracy presented only pooled outcomes, which cannot discriminate the diagnostic validity of sPGA with cut-off of PG I ≤70 ng/mL and PG I/II ≤3. Read More

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http://dx.doi.org/10.1097/MD.0000000000014240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358409PMC
January 2019
1 Read
5.723 Impact Factor

Virulence factor genotyping of Helicobacter pylori isolated from Costa Rican dyspeptic patients.

Microb Pathog 2019 Mar 14;128:276-280. Epub 2019 Jan 14.

Institute for Health Research (INISA), University of Costa Rica, San Pedro, 11501, San José, Costa Rica. Electronic address:

Background And Aims: Costa Rica is one of the countries with the highest incidence and mortality rates for gastric cancer. Helicobacter pylori infection rates are high in the whole country. We have previously shown that H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183095
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http://dx.doi.org/10.1016/j.micpath.2019.01.018DOI Listing
March 2019
6 Reads
2.000 Impact Factor

The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Gastroenterology and Center for Autoimmune Liver Diseases, ASST San Gerardo Hospital, Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.

Chronic autoimmune atrophic gastritis (CAAG) is an organ-specific autoimmune disease, which affects the corpus-fundus gastric mucosa. Although it has been described for several years, the real pathophysiological mechanisms, the natural history and the possible neoplastic complications are not completely known. Atrophy of the gastric mucosa is the endpoint of the chronic processes, with the loss of glandular cells and their replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.08.011DOI Listing
January 2019
5 Reads

Gastroesophageal reflux symptoms and microscopic esophagitis in a cohort of consecutive patients affected by atrophic body gastritis: a pilot study.

Scand J Gastroenterol 2019 Jan 13:1-6. Epub 2019 Jan 13.

a Medical-Surgical Department of Clinical Sciences and Translational Medicine , University Sapienza , Roma , Italy.

Aim: In patients affected by atrophic body gastritis (ABG) gastro-oesophageal reflux (GER) related symptoms have been reported, despite the presence of hypochlorhydria.

Objective: Objectives of this single-centre study was to assess in ABG the occurrence of GER-related symptoms and their relationship with histopathologic oesophageal findings.

Materials And Methods: Fifty-four consecutive patients (20. Read More

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http://dx.doi.org/10.1080/00365521.2018.1553062DOI Listing
January 2019
2 Reads

HOX transcript antisense RNA is elevated in gastric carcinogenesis and regulated by the NF-κB pathway.

J Cell Biochem 2019 Jan 11. Epub 2019 Jan 11.

Department of Medical Microbiology, School of Basic Medical Science, Shandong University, Jinan, Shandong, China.

The expression pattern of HOX transcript antisense RNA (HOTAIR) in the progression of gastric cancer and the regulation of its expression are still unclear. In the current study, HOTAIR expressions in gastric tissues collected from patients with superficial gastritis, atrophic gastritis, atypical hyperplasia, and gastric cancer as well as normal controls was quantitatively examined. The results showed that the expression of HOTAIR was higher in gastric cancer than in normal tissues, but reached the highest level in atrophic gastritis, suggesting that HOTAIR may be involved in the molecular process of nonresolving inflammation. Read More

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http://dx.doi.org/10.1002/jcb.28340DOI Listing
January 2019
1 Read

MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia.

Gut 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background And Aims: Gastric intestinal metaplasia (IM) is common in the gastric epithelium of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile acids and following chronic inflammation. But the mechanism underlying how bile acids activate CDX2 in gastric epithelium has not been fully explored. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315318
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http://dx.doi.org/10.1136/gutjnl-2017-315318DOI Listing
January 2019
4 Reads
14.660 Impact Factor

The incidence of neoplasia in patients with autoimmune metaplastic atrophic gastritis: a renewed call for surveillance.

Ann Gastroenterol 2019 Jan-Feb;32(1):67-72. Epub 2018 Nov 8.

Division of Gastroenterology (Nadim Mahmud, Bryson W. Katona, David C. Metz).

Background: Autoimmune metaplastic atrophic gastritis (AMAG) is an immune-mediated process that may lead to pernicious anemia (PA) and an increased risk of gastric cancer. Although some literature supports 3- or 5-year endoscopic surveillance for gastric cancer in patients with PA, no formal guidance exists for the general AMAG population. We sought to identify the prevalence and incidence rates of dysplasia or adenocarcinoma in patients with AMAG in order to clarify endoscopic best practices. Read More

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http://www.annalsgastro.gr/files/journals/1/earlyview/2018/e
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http://dx.doi.org/10.20524/aog.2018.0325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302190PMC
November 2018
10 Reads

Abnormalities in acute salivary biochemical characteristic responses to gustatory stimulation with citric acid in chronic non-atrophic gastritis.

J Gastroenterol Hepatol 2018 Dec 29. Epub 2018 Dec 29.

Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background And Aim: Salivary characteristics are altered in gastrointestinal diseases and related to oral taste disorder. However, specific salivary biochemical characteristics and their relationships with oral taste disturbances in chronic non-atrophy gastritis (CNAG) remain uncertain.

Methods: Seventy patients with CNAG and 70 subjects in healthy control group (HCG) were enrolled in our study. Read More

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http://dx.doi.org/10.1111/jgh.14587DOI Listing
December 2018
13 Reads

[Impact of Catgut Embedding Intervention on JAK 2-STAT 3 Signaling in Gastric Mucosa of Chronic Atrophic Gastritis Rats].

Zhen Ci Yan Jiu 2018 Nov;43(11):682-6

Foshan Renhe Hospital of Chinese Medicine, Foshan 528000, Guangdong Province.

Objective: To observe the impact of catgut embedding on histopathological changes and expression of phosphorylated-Janus kinase-2 (p-JAK 2), phosphorylated-signal transducer and activator of transcription 3 (p-STAT 3), Cyclin D 1, Bcl-2, and suppressor of cytokine signaling (SOCS) of the gastric mucosa in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improving CAG.

Methods: Forty-one SD rats were randomly divided into normal (=12), model (=9), natural recovery (=10) and catgut embedding (=10) groups. The CAG model was established by free drinking of N-methyl-N'-nitro-N-nitroso-guanidine (MNNG) solution (100µg/mL) and irregular diet for 24 weeks. Read More

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http://dx.doi.org/10.13702/j.1000-0607.180178DOI Listing
November 2018
3 Reads

Diagnosis of early gastric cancer based on fluorescence hyperspectral imaging technology combined with partial-least-square discriminant analysis and support vector machine.

J Biophotonics 2018 Dec 25:e201800324. Epub 2018 Dec 25.

Department of Gastroenterology and Endocrinology, The 74th Group Army Hospital of the PLA, Guangzhou, China.

This study investigated the feasibility of using fluorescence hyperspectral imaging technology to diagnose of early-stage gastric cancer. Fluorescence spectral images of 76 patients who were pathologically diagnosed as non-atrophic gastritis, premalignant lesions and gastric cancer were collected. Fluorescence spectra at 100-pixel points were randomly extracted after binarization. Read More

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http://doi.wiley.com/10.1002/jbio.201800324
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http://dx.doi.org/10.1002/jbio.201800324DOI Listing
December 2018
5 Reads

TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer.

J Gastrointestin Liver Dis 2018 Dec;27(4):363-369

Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Background And Aims: Previous genome-wide association studies showed that genetic polymorphisms in toll-like receptor 1 (TLR1) and protein kinase AMP-activated alpha 1 catalytic subunit (PRKAA1) genes were associated with gastric cancer (GC) or increased Helicobacter pylori (H. pylori) infection susceptibility. The aim of this study was to evaluate the association between TLR1 and PRKAA1 genes polymorphisms and H. Read More

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http://dx.doi.org/10.15403/jgld.2014.1121.274.tlrDOI Listing
December 2018
7 Reads

High altitude area - A risk factor for gastric perforation? : A case series.

Int J Surg Case Rep 2018 22;53:429-432. Epub 2018 Nov 22.

Department of Anaesthesia and Intensive Care, Command Hospital, Udhampur, J & K, India.

Introduction: This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017-Aug 2018), of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest.

Discussion: High altitude associated dyspepsia is a common phenomenon and some studies done in high altitude population have recorded high incidence of antral gastritis and mucosal atrophy on histo-pathological evaluation. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262768PMC
November 2018
2 Reads

Autoimmune diseases in autoimmune atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):100-103. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7919DOI Listing
December 2018
10 Reads

From Sidney to OLGA: an overview of atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):93-99. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic gastritis is a long-lasting disease that can lead to a loss of appropriate gastric glands. Gastritis, as term, apply to an inflammation of the stomach, histologically proven, sometimes with structural mucosal changes. Worldwide Helicobacter pylori's infection play a pivotal role as the main etiological effector of chronic active gastritis. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7946DOI Listing
December 2018
2 Reads

Clinical manifestations of chronic atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):88-92. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7921DOI Listing
December 2018
5 Reads

Epidemiology of gastric cancer and risk factors.

Acta Biomed 2018 Dec 17;89(8-S):82-87. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Gastric cancer is, still nowadays, an important healthcare problem worldwide. In Italy, it represents the fifth tumour by frequency in both men and women over 70 years old. A crucial point is represented by the percentage of early gastric cancers usually found, which is actually very low, and it carries to a worse morbidity and mortality. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7966DOI Listing
December 2018
2 Reads

Non-invasive method for the assessment of gastric acid secretion.

Acta Biomed 2018 Dec 17;89(8-S):53-57. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Methods for the measure of gastric acid secretion include invasive and non-invasive tests. The gold-standard to measure the acid output is the collection of gastric after in basal condition (Basal Acid Output, B.A. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7986DOI Listing
December 2018
2 Reads

Relationship between Helicobacter pylori infection and GERD.

Acta Biomed 2018 Dec 17;89(8-S):40-43. Epub 2018 Dec 17.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma.

Gastroesophageal reflux disease (GERD) is due to the chronic exposure of the esophageal mucosa to acid secretion from the stomach. Helicobacter pylori (H.p. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7918DOI Listing
December 2018
1 Read

Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS).

Methods Mol Biol 2019 ;1901:113-131

Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

The Luciferase Immuno Precipitation System (LIPS) enables the detection of specific serum antibodies by immunoprecipitation of recombinant antigens tagged with a luciferase reporter. Here we describe LIPS assays for the quantification of autoantibodies to the H+, K+-ATPase A (ATP4A) and B (ATP4B) subunits, two serological markers of autoimmune atrophic gastritis and pernicious anemia. In particular, we will describe the expression of luciferase-tagged recombinant ATP4A and ATP4B, their immunoprecipitation with test sera, the recovery and washing of immune-complexes with a protein-A coated resin, and the quantification of autoantibodies by addition of a luciferase substrate and the measurement of the light output from captured luciferase-tagged antigens. Read More

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http://dx.doi.org/10.1007/978-1-4939-8949-2_10DOI Listing
January 2019

Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.

Pancreas 2019 Jan;48(1):131-134

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.

Our group observed the first case of synchronous gastric neuroendocrine tumor (NET) and duodenal gastrinoma with autoimmune chronic atrophic gastritis (CAG), in the absence of Helicobacter pylori infection. Demographic, clinical, endoscopic, and pathologic data were abstracted from the electronic medical record at Mount Sinai Hospital from 2013 to 2015. The patient's anonymity was carefully protected, and informed consent was obtained for publication of protected health information. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001204DOI Listing
January 2019
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Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 6;316(2):G251-G262. Epub 2018 Dec 6.

Murdoch Children's Research Institute, The Royal Children's Hospital , Parkville, Victoria , Australia.

Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gastric pathology. Additionally, IL-11 is required for tumor development in STAT3-dependent murine models of gastric cancer (GC) and, when administered acutely, causes resolving atrophic gastritis. However, it is unclear whether locally elevated IL-11 ligand expression can, in isolation from oncogenic gp130-JAK-STAT pathway mutations, initiate GC pathogenesis. Read More

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http://dx.doi.org/10.1152/ajpgi.00304.2018DOI Listing
February 2019
2 Reads

Pernicious Anemia Presented with Isolated Nominal Dysphasia in Type Ill Polyglandular Failure Female Patient.

Cureus 2018 Sep 14;10(9):e3306. Epub 2018 Sep 14.

Medicine, Xavier University School of Medicine, Oranjestad, ABW.

Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis which predominantly affects the fundus of the stomach. It results in a deficiency of vitamin B12 (cobalamin) as it affects the normal process of absorption in the ileum. The pernicious anemia is characterized by a wide range of hematological and neurological features. Read More

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http://dx.doi.org/10.7759/cureus.3306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277171PMC
September 2018
3 Reads

Clinical features of Helicobacter pylori antibody-positive junior high school students in Nagano Prefecture, Japan.

Helicobacter 2018 Dec 4:e12559. Epub 2018 Dec 4.

Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.

Background: Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody-positive junior high school students.

Materials And Methods: We assessed H pylori antibody-positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. Read More

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http://dx.doi.org/10.1111/hel.12559DOI Listing
December 2018
2 Reads

Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults.

Sci Rep 2018 Dec 4;8(1):17616. Epub 2018 Dec 4.

Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel.

Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. Read More

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http://dx.doi.org/10.1038/s41598-018-35937-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279832PMC
December 2018
4 Reads

Combined Gastric and Colorectal Cancer Screening-A New Strategy.

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.

Background: Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates.

Methods: Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61. Read More

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http://dx.doi.org/10.3390/ijms19123854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321419PMC
December 2018
7 Reads

Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia.

J Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.

Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern marks a critical step in the progression from chronic gastritis to gastric cancer, yet underlying mechanism(s) of inflammation-induced cell death of gastric epithelial cells are poorly understood. We investigated direct effects of a type 1 cytokine associated with autoimmunity and infection, interferon-γ (IFN-γ), on gastric epithelial cells. Read More

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http://dx.doi.org/10.1002/path.5214DOI Listing
December 2018
3 Reads

Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis.

Case Rep Gastrointest Med 2018 30;2018:7091520. Epub 2018 Oct 30.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

In this report, we described two patients with white globe appearance in autoimmune atrophic gastritis. Endoscopy revealed multiple white substances in the stomach in both cases. Biopsied specimens from the lesions contained dilated glands and showed a decrease in parietal cells. Read More

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http://dx.doi.org/10.1155/2018/7091520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232817PMC
October 2018
8 Reads

Gastric Cancer Is the Leading Cause of Death in Italian Adult Patients With Common Variable Immunodeficiency.

Front Immunol 2018 5;9:2546. Epub 2018 Nov 5.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

An increased prevalence of malignant lymphoma and of gastric cancer has been observed in large cohorts of patients with common variable immunodeficiency (CVID), the most frequently symptomatic primary immunodeficiency. Surveillance strategies for cancers in CVID should be defined based on epidemiological data. Risks and mortality for cancers among 455 Italian patients with CVID were compared to cancer incidence data from the Italian Cancer Registry database. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230622PMC
November 2018
10 Reads

Personalized risk assessment for dynamic transition of gastric neoplasms.

J Biomed Sci 2018 Nov 19;25(1):84. Epub 2018 Nov 19.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model.

Methods: First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, including Helicobacter pylori infection, history of upper gastrointestinal disease, lifestyle, and dietary habits, on the step-by-step transition rates using data from a high-risk population in Matsu Islands, Taiwan. Second, we incorporated information on the gastric cancer carcinogenesis affected by genomic risk factors (including inherited susceptibility and irreversible genomic changes) based on literature to generate a genetic and epigenetic risk assessment model by using a simulated cohort identical to the Matsu population. Read More

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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929
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http://dx.doi.org/10.1186/s12929-018-0485-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245882PMC
November 2018
10 Reads

Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence.

PLoS One 2018 14;13(11):e0205644. Epub 2018 Nov 14.

Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.

The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205644PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241118PMC
November 2018
17 Reads

Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study.

BMC Gastroenterol 2018 Nov 8;18(1):172. Epub 2018 Nov 8.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0901-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225568PMC
November 2018
9 Reads

Deregulation of the SRC Family Tyrosine Kinases in Gastric Carcinogenesis in Non-human Primates.

Anticancer Res 2018 Nov;38(11):6317-6320

Laboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.

Background/aim: The evolution of gastric carcinogenesis remains largely unknown, as the regulatory mechanisms involved in the aggressiveness of gastric cancer are still poorly understood. Kinases are downstream modulators and effectors of various cell signaling cascades and play key roles in the development of neoplastic diseases. The objective of this study was to evaluate the expression of genes and proteins of the SRC family, including FYN, YES, BLK, FGR, LYN and SRC, in a model of intestinal gastric carcinogenesis generated by treating Cebus apella, a New World non-human primate, with N-methyl nitrosourea (MNU). Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12988DOI Listing
November 2018
16 Reads