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Ann Med Surg (Lond) 2020 Jul 18;55:143-147. Epub 2020 May 18.

Sunderland Bariatric Unit, Sunderland Royal Hospital, Sunderland, United Kingdom.

Introduction: Most Bariatric units perform Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) and One Anastomosis Gastric Bypass (OAGB) for weight loss and metabolic purposes with satisfactory results and low complication profile.

Objectives: This study compares LRYGB and OAGB outcomes in a high volume single bariatric unit.

Methods: Data was collected prospectively and analysed retrospectively for all LRYGB and OAGB performed between Jan 2014 to Dec 2016. Read More

J Vet Sci 2020 May;21(3):e39

Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.

Background: There are various species colonizing the stomachs of animals. Although usually cause asymptomatic infection in the hosts, clinical signs can occur due to gastritis associated with in animals. Among them, is strongly associated with chronic gastritis, gastric ulcers, and gastric cancers. Read More

Gastrointest Endosc 2020 May 26. Epub 2020 May 26.

National Clinical Research Center for Digestive Diseases; Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background And Aims: Magnetically controlled capsule endoscopy (MCE) has become an efficient diagnostic modality for gastric diseases. We developed a novel automatic gastric lesion detection system to assist in diagnosis and reduce inter-physician variations. This study aimed to evaluate the diagnostic capability of the computer-aided detection system for MCE images. Read More

Parkinsonism Relat Disord 2020 May 11. Epub 2020 May 11.

Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.

Disorders of the gastrointestinal (GI) tract are common and distressing nonmotor symptoms of Parkinson's disease (PD) that can adversely affect levodopa absorption and lead to OFF periods, also known as motor fluctuations. Gastroparesis, which is primarily defined as delayed gastric emptying (DGE), and Helicobacter pylori infection, which is present with increased frequency in PD, are among the most common and important GI disorders reported in PD that may impair oral levodopa absorption and increase OFF time. Symptoms of gastroparesis include nausea, vomiting, postprandial bloating, fullness, early satiety, abdominal pain, and weight loss. Read More

J Gastroenterol Hepatol 2020 May 25. Epub 2020 May 25.

Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

Background And Aim: Rates and outcomes of hospitalizations for peptic ulcer disease (PUD) are unknown in mainland China. We aimed to describe characteristics and treatments of PUD inpatients in secondary and tertiary care hospitals registered in the national Health Statistics and Information Reporting System (HSRS) in 2015, and explore factors related to inpatient outcomes.

Methods: We retrieved and validated PUD hospitalization data from 4,441 hospitals reporting to HSRS in 2015. Read More

Trends Microbiol 2020 Mar 26. Epub 2020 Mar 26.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA.

Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H. Read More

J Diet Suppl 2020 May 25:1-15. Epub 2020 May 25.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, India.

(Roxb; Family:sapotaceae) is reported to exert preventive effect in several experimental ulcer models. However, there is no report of on gastric ulcer healing property. Thus, the present study was designed to evaluate the gastric ulcer healing activity of methanolic stem bark extract of (MH) and to derive a plausible molecular level of mechanism of action. Read More

Korean J Gastroenterol 2020 May;75(5):292-295

Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Peptic ulcer disease is common and can be diagnosed easily if the patient has an ulcer history or characteristic abdominal symptoms. On the other hand, it may take a long time for the patient to visit the hospital due to severe complications if the patient is old or insensitive to symptoms caused by peptic ulcers. In the present case, a 72-year-old female visited the hospital due to general weakness and inadequate oral intake, which started two weeks ago. Read More

Zhen Ci Yan Jiu 2020 May;45(5):379-83

School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.

Objective: To investigate the effect of acupuncture on serum inflammatory cytokines and intestinal flora in rats with stress-induced gastric ulcer (SGU), and to explore the mechanism of acupuncture in the treatment of SGU.

Methods: Sprague-Dawley rats were randomly divided into blank, model, acupuncture, and medication groups, with 7 rats in each group. Restraint water-immersion stress was used to establish the model of SGU. Read More

J Ethnopharmacol 2020 May 19;259:112979. Epub 2020 May 19.

Hunan Provincial Key Laboratory of Translational Research in TCM Prescriptions and Zheng, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China. Electronic address:

Ethnopharmacological Relevance: Li-Zhong-Tang (LZT) is a well-known Chinese herbal formulation first described in one of traditional Chinese medicine (TCM) scriptures, Treatise on Febrile Diseases. LZT has been commonly prescribed for the treatment of various gastrointestinal diseases for over 1800 years, and has demonstrated pronounced therapeutic effects on patients with gastric ulcers.

Aim Of The Study: The present study aimed to scientifically evaluate protective effects of LZT on indomethacin (IND)-induced gastric injury in rats and to elucidate whether LZT exerts its gastro-protective effects via enhancing mucosal immunity by regulating TLR-2/MyD88 signaling pathway. Read More

J Surg Case Rep 2020 May 18;2020(5):rjz195. Epub 2020 May 18.

Metabolic and Bariatric Surgery, Lakes Region General Hospital, Clinical Assistant Professor of Surgery, University of New England College of Osteopathic Medicine.

Nissen fundoplication is a safe and effective procedure for gastroesophageal reflux. Gastric ulceration leading to perforation is an uncommon late complication with a mechanism of action that is poorly understood. A 40-year-old male presented 3 years following his fundoplication with a perforated ulcer in the upper body of the stomach. Read More

Curr Pharm Des 2020 May 21. Epub 2020 May 21.

Department of Pharmacology, St Francis Xavier University, Antigonish, Nova Scotia. Canada.

Stress gastric ulceration is a clinical condition leading to morbidity/mortality and complex etiopathological factors are involved. Pharmacotherapy of such gastric mucosal lesions is not consistent and novel strategies are being explored. Targeting gastrointestinal factors have showed equivocal results and there is a possibility of involvement extra-gastrointestinal factors. Read More

J Pathol Transl Med 2020 May 22. Epub 2020 May 22.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang.

Crystal-storing histiocytosis (CSH) is a rare entity that is characterized by intrahistiocytic accumulation of crystallized immunoglobulins. CSH is not a malignant process per se, but the majority of CSH cases are associated with underlying lymphoproliferative disorder. Although CSH can occur in a variety of organs, gastric CSH is very rare. Read More

Surg Endosc 2020 May 18. Epub 2020 May 18.

Division of General Surgery, University Health Network, Toronto, ON, Canada.

Background: Marginal ulcer formation is a known complication following RYGB. While most respond to medical therapy, many patients have recurrent or chronic MU. Although non-steroidal anti-inflammatory drug (NSAID) use, smoking and Helicobacter pylori infection are known risk factors of MU, little is known about what increases the likelihood of developing recalcitrant ulcers. Read More

Surg Endosc 2020 May 18. Epub 2020 May 18.

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: To establish and validate a model to determine the progression risk of gastric low-grade intraepithelial neoplasia (LGIN).

Methods: A total of 705 patients with gastric LGIN at the endoscopy center of Jiangsu Provincial People's Hospital during January 2010 and August 2017 were retrospectively reviewed. Basic clinical and pathological information were recorded. Read More

BMC Res Notes 2020 May 18;13(1):245. Epub 2020 May 18.

Department of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.

An amendment to this paper has been published and can be accessed via the original article. Read More

AAPS PharmSciTech 2020 May 17;21(5):137. Epub 2020 May 17.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, P.O.Box: 80260, Jeddah, 21589, Saudi Arabia.

In the global incidence of peptic ulcer, with the associated rates of hospitalizations and mortality are increasing, in the United States, peptic ulcer disease affects approximately 4.6 million people annually, with an estimated 10% of the US population having evidence of a duodenal ulcer. The present research aims to find a novel treatment for ethanol induced ulcer by loading thymoquinone (TQ) on a nanostructured lipid carrier (NLC), using Compritol® 888 and coconut oil. Read More

Obes Surg 2020 May 16. Epub 2020 May 16.

Body Science and Metabolic disorders International Medical Center, China Medical University Hospital, Yude Rd., North Dist, Taichung, Taiwan.

Introduction: Biliopancreatic limb obstruction is a surgical emergency in patients who have undergone gastric bypass surgery. This case report presents an unexpected cause of biliopancreatic limb obstruction and the importance of prompt intervention.

Material And Methods: A 37-year-old woman presented with complaints of weight regain (BMI increased from 27 to 33. Read More

Minerva Stomatol 2020 May 14. Epub 2020 May 14.

Unit of Stomatology and Oral Surgery, Department of Surgical, Medical, Molecular and Critical Needs Pathologies, University-Hospital of Pisa, University of Pisa, Pisa Italy.

Background: Dental implants placed in medically compromised patients have predictable outcomes and a high rate of survival, compared to those placed in healthy patients. The aims of this study were to observe and compare implant survival/success rates and soft tissue response to tissue-level implants placed in healthy and medically compromised patients with a 1-year follow-up.

Methods: 72 patients, 36 healthy patients (20 Females and 16 Males) and 36 medically compromised patients (18 Females and 18 Males) affected by Cardiovascular Diseases (Arrythmia, Hypertension, Atrial Fibrillation, Bypass and Pacemaker surgery), Depression, Endocrinous metabolic diseases (Hypercholesterolemia, Type II Diabetes, Hashimoto's Thyroiditis), Gastrointestinal diseases (Gastritis, Hiatal Hernia, Gastric Ulcers), Asthma, Osteoporosis or Glaucoma received one tissue-level implant. Read More

Iran J Basic Med Sci 2020 Feb;23(2):224-235

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad.

Objectives: This study was designed to investigate various gastrointestinal effects of (Sapodilla), exploring its anti-diarrheal, anti-secretary, anti-spasmodic, anti-ulcer and anti-motility potential.

Materials And Methods: Antidiarrheal and anti-secretary activities were investigated using castor oil induced diarrhea and castor oil induced fluid accumulation. Isolated rabbit jejunum tissues (antispasmodic) were employed for experiments. Read More

Gastrointest Tumors 2020 Apr 6;7(1-2):21-29. Epub 2019 Nov 6.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background/aims: It is important to appropriately manage patients with procedure-related artificial mucosal ulcers or procedure-related complications. Many endoscopic closure techniques have been reported; however, they often require the use of special devices. We developed a single-channel endoscopic closure technique (SCCT) that can be performed with conventional devices. Read More

Crit Care Resusc 2020 Jun;22(2):105-109

Intensive Care Unit, Royal Perth Hospital, Perth, WA, Australia.

Gan To Kagaku Ryoho 2020 Feb;47(2):373-375

Dept. of Surgery, Kansai Electric Power Hospital.

A Japanese man in his 60s presented with complaints of epigastric pain and weight loss. A gastrointestinal endoscopy revealed multiple gastric ulcers and an irregular mound located on the wall of the lower gastric body along the greater curvature, which was suspected to be cancerous. A biopsy revealed that it was a Group 2 tumor even though the biopsy was repeated 4 times. Read More

Gan To Kagaku Ryoho 2020 Jan;47(1):156-158

Division of Surgery, Saiseikai Kumamoto Hospital.

Purpose: Perforated marginal ulcer after pancreaticoduodenectomy(PD)is a delayed complication. We evaluated the characteristics of the patients presenting perforated marginal ulcer after PD.

Methods: Five cases of perforated marginal ulcer after PD were reported at our hospital between 2008 and 2018, and the characteristics of these patients were evaluated. Read More

Foods 2020 May 3;9(5). Epub 2020 May 3.

Departamento de Ciencias Químicas, Universidad Andres Bello, Campus Viña del Mar, Quillota 980, Viña del Mar, 2531098 Valparaiso, Chile.

J. Remy (Solanaceae) is commonly used as an infusion in traditional medicine to treat stomach pain, meteorism, intestinal disorders, stomach ailments, and other severe problems including prostate cancer and stomach cancer. From the EtOAc extract of bark five known metabolites were isolated using chromatographic techniques. Read More

Iran J Basic Med Sci 2019 Jul;22(7):710-715

Geriatrics Department, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.

Objectives: The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of .

Materials And Methods: The literature was searched on "PubMed" using different key words including , CEACAM and gastric.

Results: HopQ is one of the outer membrane proteins of and belongs to the family of adhesin proteins. Read More

J Clin Med 2020 May 1;9(5). Epub 2020 May 1.

Department of Medicine and Surgery Sciences, University of Bologna, 40138 Bologna, Italy.

: () infection is the leading cause of both peptic ulcers and gastric tumors, including low-grade MALT-lymphoma and adenocarcinoma. Although it is decreasing in developed countries, prevalence remains high in developing areas, mainly due to low socio-economic levels, and the potential consumption of contaminated water. Moreover, a different pattern of primary antibiotic resistance is expected in their isolates, potentially affecting the efficacy of standard eradication therapies. Read More

Chirurgia (Bucur) 2020 Mar-Apr;115(2):220-226

Specific risk factors for gastroduodenal surgery in cirrhotic patients have been identified, which dictates for a more personalized management. The retrospective study was conducted between 2012-2019 on twelve patients (7 cases of duodenal ulcer, 2 cases of gastric ulcer and 3 patients with gastric cancer). We took into account a number of possible factors involved in the unfavorable evolution of patients, based on data published in the literature so far. Read More

World J Clin Cases 2020 Apr;8(8):1454-1462

Centre of Hepatology, Gastroenterology and Dietetics, Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania.

Background: Differential diagnosis between extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies, although there is no single definitive diagnostic investigation and that circumstance can lead to misdiagnosis in particular cases. Herein we present a rare, ulcerative form of marginal zone lymphoma which mimics the Crohn's disease (CD) of upper digestive tract.

Case Summary: A 50-year-old man was presented with recurrent episodes of malaise and melena also weight loss. Read More

J Clin Med Res 2020 Apr 30;12(4):269-271. Epub 2020 Mar 30.

West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV 24901, USA.

The potential for splenic injury from esophagogastroduodenoscopy (EGD) is exceptionally low. To our knowledge, less than five cases have been reported in literature. Though still uncommon, splenic rupture due to diagnostic or therapeutic procedures is more frequently described following colonoscopy and endoscopic retrograde cholangiopancreatography. Read More

J Ethnopharmacol 2020 Aug 30;258:112920. Epub 2020 Apr 30.

Ege University, Faculty of Pharmacy, Department of Pharmacognosy, Bornova, 35040, Izmir, Turkey. Electronic address:

Ethnopharmacological Relevance: Aerial parts of Sideritis caesarea H. Duman, Aytaç & Başer are used for complaints such as stomach-aches, and intestinal spasms as traditional medicine in Kayseri, Turkey.

Aim Of Study: To investigate the anti-ulcerogenic activity by using bioassay guided fractionation technique (BAGF) and to identify the compound(s) that are responsible for anti-ulcerogenic activity through ethanol-induced anti-ulcerogenic activity model in vivo. Read More

Medicine (Baltimore) 2020 May;99(18):e20030

Department of Hematology.

Introduction: Complications such as severe infection may occur during the chemotherapy of malignant lymphoma. Phlegmonous gastritis (PG) is a rare acute bacterial infection associated with high mortality, requiring early diagnosis, and prompt management. In addition, Guillain-Barré syndrome (GBS) occasionally requires early treatment and intensive care management due to the occurrence of severe neuropathy and respiratory failure. Read More

Visc Med 2020 Apr 14;36(2):137-143. Epub 2019 May 14.

Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Background And Aim: is one of the most common pathogenic bacteria in the human gut, and is also one of the most important factors that cause digestive disorders such as chronic inflammation, gastric ulcers, and even gastric cancer. Since the use of various antibiotics to treat infection is associated with the development of resistance in this bacterium, the aim of this study was to determine the anti- effects of , and in the stomach tissue of C57BL/6 mice.

Materials And Methods: In this experimental study, 70 mice in ten groups were evaluated from July to September 2017 in the microbiology laboratory of the School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Read More

Am J Surg Pathol 2020 Apr 28. Epub 2020 Apr 28.

Departments of Pathology and Laboratory Medicine.

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoproliferation encompasses a broad range of clinicopathologic findings, including specific subtypes, for example, EBV mucocutaneous ulcer. Here we reassessed 36 cases of primary EBV diffuse large B-cell lymphomas (16 men and 20 women; median age, 69.5 y; range, 35 to 84 y), including 8 immunosuppressed patients (Lugano stage II-IV; median age, 74 y), 7 nonimmunosuppressed patients with stage I disease (median age, 69 y), and 21 nonimmunosuppressed patients with stage II-IV disease (median age, 69 y). Read More

J Dig Dis 2020 Apr 29. Epub 2020 Apr 29.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Military Medical University, Xi'an, Shaanxi Province, China.

Aim: The infection of Helicobacter pylori (H. pylori) has a close association with gastric ulcers and gastric adenocarcinoma. This study was designed to assess the efficacy and safety of quadruple regimen with amoxicillin plus berberine vs tetracycline plus furazolidone in H. Read More

Food Funct 2020 May 29;11(5):4123-4137. Epub 2020 Apr 29.

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China.

Human-like collagen (HLC), the collagen produced using fermentation technology, has been demonstrated previously to promote wound healing. However, the healing property of HLC in gastric ulcers remains to be verified. In this study, we investigated the healing efficacy and healing mechanisms of HLC on gastric ulcers. Read More

Clin Exp Gastroenterol 2020 15;13:99-104. Epub 2020 Apr 15.

Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Potassium-competitive acid blockers (P-CABs), such as vonoprazan, represent a novel and heterogeneous class of drugs that competitively block the potassium binding site of gastric H/K ATPase, thus potentially overcoming the limitations of proton-pump inhibitors. Different studies evaluated the efficacy of vonoprazan versus proton-pump inhibitors (PPIs) for the treatment of acid-related disorders, and, therefore, P-CABs present the same indications of PPIs: gastroesophageal reflux disease, gastric and duodenal ulcer healing, management of upper gastrointestinal bleeding, non-steroidal anti-inflammatory drug (NSAID)-associated ulcers and eradication therapy. The aim of this review was to evaluate the role of vonoprazan for the treatment of peptic ulcer disease (PUD) and the management of gastric ulcer occurring after endoscopic submucosal dissection (ESD). Read More

Int J Nanomedicine 2020 15;15:2529-2539. Epub 2020 Apr 15.

Advanced Drug Delivery Research Group, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Background: Peptic ulcer disease, a painful lesion of the gastric mucosa, is considered one of the most common gastrointestinal disorders. This study aims to investigate the formulation of pumpkin seed oil (PSO)-based nanostructured lipid carriers (NLCs) to utilize PSO as the liquid lipid component of NLCs and to achieve oil dispersion in the nano-range in the stomach.

Methods: Box-Behnken design was utilized to deduce the optimum formula with minimum particle size. Read More

J Dev Orig Health Dis 2020 Apr 29:1-7. Epub 2020 Apr 29.

Department of Physiology, Federal University of Uberlândia, Uberlândia, Brazil.

Alterations in the maternal environment may impact on the fetal development. The objective of this study was to investigate the gastrointestinal consequences of maternal hypothyroidism for the male offspring from Wistar rats. The pregnant rats were divided into three groups: control (C - received water), experimental 1 [E1 - received methimazole (MMI) solution] during gestation and lactation, and experimental 2 (E2 - received MMI solution) during gestation. Read More

Environ Sci Pollut Res Int 2020 Apr 28. Epub 2020 Apr 28.

Department of Anatomy, Alexandria University, Alexandria, Egypt.

Gastric ulcer is a worldwide disease. Helicobacter pylori is one of the most common chronic bacterial infections that induce chronic inflammation in the gastric mucosa, mediated by an array of pro-and inflammatory cytokines. The aim of this study was to investigate the possible therapeutic effects of Ginkgo biloba extract on gastric ulcer induced by ammonium hydroxide in rats and the potential underlying mechanisms. Read More

J Clin Gastroenterol 2020 Apr 24. Epub 2020 Apr 24.

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Goals: We assessed the efficacy of polaprezinc plus proton pump inhibitor (PPI) treatment for endoscopic submucosal dissection (ESD)-induced ulcer healing compared with rebamipide plus PPI treatment.

Background: ESD has been widely used as a local treatment option that cures gastric neoplasms. However, it causes large and deep artificial ulcers, and there are no guidelines with regard to the optimal treatment durations and drug regimens for ESD-induced ulcers. Read More

Cells 2020 Apr 23;9(4). Epub 2020 Apr 23.

Clinica Medica A. Murri, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, 70126 Bari, Italy.

() is one of the most common human pathogens, affecting half of the world's population. Approximately 20% of the infected patients develop gastric ulcers or neoplastic changes in the gastric stroma. An infection also leads to the progression of epithelial-mesenchymal transition within gastric tissue, increasing the probability of gastric cancer development. Read More

Drugs R D 2020 Jun;20(2):115-124

Clinical Pharmacology Unit, Department I of Pharmacology, Center for Pharmacology, University Hospital Cologne (AöR), Gleueler Straße 24, 50931, Köln, Germany.

Background And Objective: Beyond its application for diagnostics in patients, esophagogastroduodenoscopy (EGD) is used to assess gastrointestinal drug effects in clinical trials, where the interpretation of any pathological findings depends on the respective background variability. The objective of this analysis was to characterize the occurrence of pathological findings in the upper gastrointestinal tract in symptom-free healthy individuals.

Methods: A baseline EGD was performed in clinically healthy individuals in three clinical trials aimed to assess gastrointestinal tolerability of drugs. Read More

Curr Pharm Des 2020 Apr 24. Epub 2020 Apr 24.

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Salata 11, POB 916, 10000 Zagreb. Croatia.

This review is focused on the healing of fistulas and stable gastric pentadecapeptide BPC 157. Assuming that the healing of the various wounds is essential also for the gastrointestinal fistulas healing, the healing effect on fistulas in rats, consistently noted with the stable gastric pentadecapeptide BPC 157, may raise several interesting possibilities. BPC 157 is originally an anti-ulcer agent, native to and stable in human gastric juice (for more than 24 h). Read More

Gut Liver 2020 Apr 27. Epub 2020 Apr 27.

Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Proton pump inhibitors (PPIs) are used worldwide to treat of acid-related disorders such as peptic ulcer and gastroesophageal reflux disease and to prevent gastroduodenal injuries due to nonsteroidal anti-inflammatory drugs. PPIs are the most potent inhibitors of gastric acid secretion currently available, and they are one of the most commonly prescribed classes of drugs because of their high efficacy and low toxicity. However, long-term PPI use causes histopathological changes such as parietal cell protrusion into the gland lumen, cystic dilation of gastric fundic glands, and foveolar epithelial hyperplasia. Read More

BMC Res Notes 2020 Apr 23;13(1):230. Epub 2020 Apr 23.

Department of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.

Objective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Read More

Biomolecules 2020 Apr 15;10(4). Epub 2020 Apr 15.

Department of Integrative Biotechnology, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon 16419, Korea.

Alverine, a smooth muscle relaxant, is used to relieve cramps or spasms of the stomach and intestine. Although the effects of alverine on spontaneous and induced contractile activity are well known, its anti-inflammatory activity has not been fully evaluated. In this study, we investigated the anti-inflammatory effects of alverine in vitro and in vivo. Read More

J Laparoendosc Adv Surg Tech A 2020 Apr 22. Epub 2020 Apr 22.

Division of Bariatric Surgery, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.

Laparoscopic sleeve gastrectomy (LSG) is the most commonly performed bariatric procedure in the world, with 75% of the primary procedures performed in the United States. It is a safe and effective primary bariatric procedure with good weight loss. When comparing with other procedures, LSG is limited to the stomach, avoiding the presence of internal hernias, preserving the pyloric anatomy, with normal gastric emptying, and conveying less severe rebound hypoglycemia. Read More

Biomarkers 2020 Jun 7;25(4):349-359. Epub 2020 May 7.

Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, Egypt.

Stomach ulcer is one of the most prevalent disorders worldwide. The study was aimed to isolate and characterize the major polymethoxylated flavonoids in peels petroleum ether extract and investigate its protective and curative effect on gastric ulcer. Some spectral analyses were used for identification of the isolated compounds from the petroleum ether extract of peels. Read More

Biochem Res Int 2020 31;2020:7656127. Epub 2020 Mar 31.

Department of Pharmacology, School of Pharmacy, University of Ghana, Legon, Accra, Ghana.

is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based data is unavailable. Read More