Search Our Scientific Publications & Authors

J Ethnopharmacol 2022 May 13:115388. Epub 2022 May 13.

Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, PR China. Electronic address:

Ethnopharmacological Relevance: Zanthoxylum nitidum (Roxb.) DC. (Z. Read More

Equine Vet J 2022 May 16. Epub 2022 May 16.

School of Veterinary Medicine, University College Dublin, Ireland.

Background: As the primary decision-maker for their horse's health and welfare, owners' knowledge of clinical conditions may impact their horse's health. Anecdotal evidence suggests that the emotional impact of equine illness on the owner can be severe but research is lacking.

Objectives: To evaluate horse owners' self-declared knowledge of eight common equine health conditions and perceptions of the quality of information available; to ascertain respondents' perceptions of the severity of impact on their horse of the conditions and potential emotional impact on themselves and to establish the factors of greatest concern to owners when their horse has a health condition and influential factors on end-of-life decisions. Read More

Front Pharmacol 2022 27;13:894808. Epub 2022 Apr 27.

Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

To investigate the value of magnetically guided capsule endoscopy (MGCE) and magnetic resonance enterography (MRE) in assessing the activity of pediatric Crohn's disease. Clinical data from 82 subjects with pediatric Crohn's disease, who underwent MGCE and MRE from October 2018 to March 2021 were analyzed retrospectively. Pairwise comparisons of several indexes, including MaRIA, CECDAI, PCDAI, and SES-CD, were performed by Spearman's rank correlation test and kappa consistency analysis. Read More

Rev Recent Clin Trials 2022 May 13. Epub 2022 May 13.

Department of Internal medicine No.2, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.

Background - One of the most important problem associated with treatment of the rheumatoid arthritis (RA) is erosive-ulcerative lesions (EUL) of the gastroduodenal zone, which is associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim: Aim of our research is to study the clinical and histo-morphological criteria for the formation of the EUL of the gastroduodenal zone in patients with RA. Methods - Patients were divided into 3 groups, depending on the presence of an EUL, according to fibrogastroduodenoscopy (FGDS) data with a negative test for H. Read More

BMJ Case Rep 2022 05 13;15(5). Epub 2022 May 13.

4th Department of Surgery, General University Hospital Attikon, Athens, Greece

Molecules 2022 Apr 30;27(9). Epub 2022 Apr 30.

IZKF Core Unit Proteomics, University of Münster, 48149 Münster, Germany.

Background: A gastric cancer (GC) diagnosis relies on histopathology. Endoscopy rates are increasing. infection is a major GC risk factor. Read More

Cancers (Basel) 2022 May 9;14(9). Epub 2022 May 9.

Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, 15213 PA, USA.

Interactions between the immune system and the nervous system are crucial in maintaining homeostasis, and disturbances of these neuro-immune interactions may participate in carcinogenesis and metastasis. Nerve endings have been identified within solid tumors in humans and experimental animals. Although the involvement of the efferent sympathetic and parasympathetic innervation in carcinogenesis has been extensively investigated, the role of the afferent sensory neurons and the neuropeptides in tumor development, growth, and progression is recently appreciated. Read More

Cancers (Basel) 2022 May 2;14(9). Epub 2022 May 2.

Division of General Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan.

The extended scope of upper gastrointestinal cancer can include esophageal cancer, gastric cancer and pancreatic cancer. A higher incidence rate of gastric cancer and esophageal cancer in patients with liver cirrhosis has been reported. It is attributable to four possible causes which exist in cirrhotic patients, including a higher prevalence of gastric ulcers and congestive gastropathy, zinc deficiency, alcohol drinking and tobacco use and coexisting gut microbiota. Read More

J Med Food 2022 May;25(5):513-522

Laboratory of Functional Physiology and Bio-resources Valorisation, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia.

(Fenugreek) is used in traditional phytomedicine for its anti-inflammatory, antiseptic, antidiabetic, and several other therapeutic virtues. The current study was intended to investigate the protecting effects of fenugreek seeds' aqueous extract (FSAE) using experimentally ethanol (EtOH)-induced gastric peptic ulcer in rats, as immense alcohol consumption can lead to gastric ulcer. Sixty adult male Wistar rats were divided into 6 groups of 10 each: control, EtOH (4 g/kg body weight [b. Read More

Environ Sci Pollut Res Int 2022 May 12. Epub 2022 May 12.

Department of Medical Physiology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.

This study evaluated the protective potentials of Moringa oleifera leaf alcoholic extract (MOLE) against bisphenol A (BPA)-induced stomach ulceration and inflammation in rats. Control rats received olive oil. Second group administered MOLE (200 mg/kg bwt) by oral gavage. Read More

Curr Pharm Des 2022 May 12. Epub 2022 May 12.

State University of Paraíba, R. Baraúnas, 351, Cidade Universitária, Campina Grande, Paraíba, 58429-500, Brasil.

Peptic ulcer is a lesion located in the esophagus, stomach, and upper intestine, caused by an imbalance between acid secretion and the release of protective mucus. This pathology is prevalent in approximately 14% of the world population and is commonly treated with proton pump inhibitors and type 2 histaminergic receptor antagonists, however, these drugs present concerning side effects that may lead to gastric cancer. In this sense, this research aimed to present the main heterocyclics studied in recent years. Read More

Front Microbiol 2022 25;13:835313. Epub 2022 Apr 25.

Rajiv Gandhi Centre for Biotechnology, Trivandrum, India.

It is increasingly being recognized that severe gastroduodenal diseases such as peptic ulcer and gastric cancer are not just the outcomes of infection in the stomach. Rather, both diseases develop and progress due to the perfect storms created by a combination of multiple factors such as the expression of different virulence proteins, consequent human immune responses, and dysbiosis in gastrointestinal microbiomes. In this mini review, we have discussed how the genomes of and other gastrointestinal microbes as well as the genomes of different human populations encode complex and variable virulome-immunome interplay, which influences gastroduodenal health. Read More

Rev Esp Enferm Dig 2022 May 12. Epub 2022 May 12.

Aparato Digestivo, Hospital Royo Villanova, España.

A 74-year-old patient presented to our emergency department with melena for 24 hours, associated with postprandial abdominal pain, predominantly in the epigastrium, for one month. Urgent gastroscopy showed a pale mucosa with loss of vascular pattern in the gastric antrum, as well as several superficial ulcers, Forrest III, at that level and in the duodenal bulb highly suggestive of ischaemia. An abdominal computed tomography angiography (CTA) revealed a filiform celiac trunk, with calcified atherosclerotic plaques in the ostium, superior mesenteric artery and both renal arteries, with absence of enhancement in a large part of the intestinal wall, suggestive of ischaemia. Read More

Arthritis Res Ther 2022 May 10;24(1):103. Epub 2022 May 10.

Department of Medicine, The University of Melbourne at St Vincent's Hospital (Melbourne), 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia.

Background: To describe the epidemiology, determinants and survival impact of gastric antral vascular ectasia (GAVE) in systemic sclerosis (SSc).

Methods: Consecutive SSc patients prospectively enrolled in the Australian Scleroderma Cohort Study (ASCS) were included. Univariable and multivariable logistic regression were used to determine the associations of GAVE with clinical manifestations and serological parameters. Read More

Saudi J Biol Sci 2022 Apr 20;29(4):3040-3050. Epub 2022 Jan 20.

Biology Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Recent years have reported a rise in the occurrence of gastric ulceration especially among young children and adults. This study investigated the mechanism by which two types of Saudi honey: Alnahal Aljawal honey (Wadi) or Bin Ghaithan honey (Talh) exerted their antiulcer potential in indomethacin-induced gastric ulceration. Four cohorts of rats were used: Group 1; Healthy controls, Group 2; Ulcerative animals, Group 3; Ulcerative + Wadi honey treatment, Group 4; Ulcerative + Talh honey treatment. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2022 Apr;24(4):372-376

Department of Pediatric Gastroenterology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110000, China.

Objectives: To study the clinical manifestations and gastroscopic characteristics of upper gastrointestinal ulcer in children.

Methods: A retrospective analysis was performed for the children who underwent gastroscopy and were found to have upper gastrointestinal ulcer for the first time at the Endoscopy Center of Shengjing Hospital, China Medical University, from January 2011 to May 2021. According to the cause of the disease, they were divided into primary ulcer group (primary group; =148) and secondary ulcer group (secondary group; =25). Read More

Biochem Biophys Res Commun 2022 Apr 25;612:162-168. Epub 2022 Apr 25.

Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, 24341, Republic of Korea; Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address:

Helicobacter pylori is a pathogenic bacterium that causes gastric ulcers and cancer. Among the diverse virulence genes of H. pylori, the IceA gene was identified to be expressed upon adherence to host cells. Read More

Iran J Allergy Asthma Immunol 2022 Feb 6;21(1):20-26. Epub 2022 Feb 6.

Department of Immunology, Cellular and Molecular Research Center, Basic Health Sciences Institute, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Interleukin (IL)-35 and IL-37 are two anti-inflammatory cytokines. IL-35 inhibits the development of T-effector cells such as Th1, and Th17; while increasing regulatory T cells (Tregs). IL-37 causes the suppression of inflammatory cytokines. Read More

Tierarztl Prax Ausg G Grosstiere Nutztiere 2022 Apr 6;50(2):91-100. Epub 2022 May 6.

Departement für Nutztiere, Vetsuisse-Fakultät, Universität Zürich.

Objective: A number of laboratory abnormalities occurs in cows with traumatic reticuloperitonitis (TRP) as well as in those with abomasal ulcers (U; classified as type 1 to 5). The goal of our study was to compare the frequency of individual laboratory variables of cows with traumatic reticuloperitonitis and cows with abomasal ulcers and determine the diagnostic significance of individual laboratory variables.

Material And Methods: The present study included 182 healthy control cows, 503 cows with TRP, 94 cows with U1, 145 cows with U2, 60 cows with U3, 87 cows with U4 and 14 cows with U5. Read More

ACS Biomater Sci Eng 2022 May 5. Epub 2022 May 5.

Chemical Biology Unit, Institute of Nano Science and Technology (INST), Knowledge City, Sector 81, Mohali, Punjab 140306, India.

Gastric ulcer (GU) is the most common and chronic inflammatory condition mediated by multiple immune cells like neutrophils, macrophages, and lymphocytes with multiple pro-inflammatory cytokine interleukins such as IL-8, IL-10, IL-β, and interferon-γ (IFN-γ). Copper (Cu) is one of the essential micronutrients mainly found in the liver and brain. It plays a major role in metabolism, enzyme conversion, free radical scavenging, trafficking agents, and many others. Read More

Toxicol Res (Camb) 2022 Apr 31;11(2):325-338. Epub 2022 Mar 31.

Department of Pharmacology, Faculty of Medicine, Benha University, Benha 13511, Egypt.

This study examined if wheat germ oil (WGO) has gastroprotective impacts against ethanol-induced gastric ulcer in rats. Rats were assigned into control, WGO, ethanol, omeprazole + ethanol, and WGO + ethanol. WGO prevented gastric ulceration and damage induced by ethanol, the same effect induced by omeprazole, a widely known medication used for gastric ulcer treatment. Read More

Rev Gastroenterol Mex (Engl Ed) 2022 May 1. Epub 2022 May 1.

Universidad de Granada, Granada, Spain.

Introduction And Aim: The gastric mucosa has been studied since the pre-Helicobacter pylori (H. pylori) era, but the complete descriptions of the stomach and duodenum have been anecdotal, and those of the distal duodenum, exceptional. Our aim was to evaluate the different epidemiologic characteristics and the gastroduodenal inflammatory status in patients with upper gastrointestinal symptoms. Read More

Psychiatr Danub 2021 Spring-Summer;33(Suppl 4):1248-1253

School of Medicine, University of Zagreb, Šalata 4, 10000 Zagreb, Croatia.

In the last 40 years there has been a 6-fold increase in the number of earthquakes worldwide. Devastating earthquakes, 5.5 and 6. Read More

Autops Case Rep 2022 20;12:e2021376. Epub 2022 Apr 20.

Catharina Hospital, Catharina Cancer Institute, Department of Gastroenterology and Hepatology, Eindhoven, The Netherlands.

Front Med (Lausanne) 2022 12;9:846024. Epub 2022 Apr 12.

Department of Gastroenterology, Xiangya Hospital of Central South University and Hunan International Computer Aided Diagnosis and Treatment for Digestive Disease, Changsha, China.

A large percentage of the world's population is affected by gastric diseases ranging from erosion and ulcer to serious ailments such as gastric cancer, which is mainly caused by Helicobacter pylori(H.pylori) infection. While most erosions and ulcers are benign, severe cases of gastric diseases can still develop into cancer. Read More

Int J Surg Pathol 2022 May 2:10668969221098094. Epub 2022 May 2.

Department of Pathology, Binzhou People's Hospital, Binzhou, China.

Malignant peripheral nerve sheath tumor (MPNST) is a spindle cell sarcoma originating from peripheral nerves or showing differentiation of nerve sheath components. Primary MPNST of the stomach is an extremely rare neoplasm with only a few published reports in the literature. We present the case of a 58-year-old male patient with MPNST in the stomach. Read More

ANZ J Surg 2022 May 1. Epub 2022 May 1.

Department of Surgery, Jersey General Hospital, Jersey, UK.

Background: The One Anastomosis Gastric Bypass (OAGB) is a relatively novel procedure. Studies have demonstrated that it is at least as effective as other bariatric procedures but with fewer major complications and shorter operating time, yet OAGB is performed less partially due to a paucity of supportive evidence. We report the outcomes of a prospectively maintained database of patients undergoing laparoscopic OAGB. Read More

J Cardiovasc Electrophysiol 2022 Apr 30. Epub 2022 Apr 30.

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Introduction: Direct comparison studies about the incidence of esophagogastric complications between radiofrequency (RF) and cryoballoon (CB) catheter ablation (CA) for atrial fibrillation (AF) have been scarce. We sought to elucidate the relationship between the pulmonary vein isolation (PVI) modalities and esophagogastric complications.

Methods: The study population consisted of 254 patients who underwent CA for AF from November 2017 to October 2018. Read More

Eur J Pharmacol 2022 Apr 26:174976. Epub 2022 Apr 26.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Gastritis is a common inflammation of stomach with multiple pathogenesis. This study was designed to investigate the protective effects of oral octreotide (OCT) against ethanol-induced acute gastric injury and H. pylori-induced chronic gastritis via promoting gastric mucosa restoration, reducing gastric acid secretion and inflammation. Read More