44,388 results match your criteria Gastric Ulcers


Laparoscopic One Anastomosis Gastric Bypass Versus Laparoscopic One Anastomosis Gastric Bypass with Braun Anastomosis: What's Better?

J Laparoendosc Adv Surg Tech A 2019 Apr 23. Epub 2019 Apr 23.

Department of General and Oncological Surgery, Policlinico San Marco, Zingonia, Italy.

Although laparoscopic one anastomosis gastric bypass (LOAGB) is a promising bariatric procedure, a large number of surgeons have strong objections mainly because of risk of bile reflux, marginal ulceration, malnutrition, and long-term risk of gastric and esophageal cancer. Lateral enteroenterostomy placed distally to a gastrojejunal anastomosis shows efficacy in preventing bile reflux after gastric resection and gastrojejunal anastomosis, but at present its efficacy in a bariatric surgery context has not been evaluated. From January 2013 to December 2018, 100 patients have been admitted to our department to be treated by performing LOAGB. Read More

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http://dx.doi.org/10.1089/lap.2019.0218DOI Listing
April 2019
1 Read

Non-malignant Helicobacter pylori-Associated Diseases.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Helicobacter pylori infection of the human stomach is associated with chronic gastritis, peptic ulcer disease or gastric carcinoma, and thus a high burden for the public health systems worldwide. Fortunately, only a small subfraction of up to 15-20% of infected individuals will develop serious complications. Unfortunately, it is not always known upfront, who will be affected by serious diesease outcome. Read More

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http://dx.doi.org/10.1007/5584_2019_362DOI Listing

Safety and location analysis of transumbilical endoscopic submucosal dissection with single-basin lymph node dissection in the upper gastric body: a porcine model.

Surg Endosc 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea.

Background: In our previous study, transumbilical endoscopic submucosal dissection (TU-ESD) was revealed to be feasible, but delayed gastric perforation was observed in 30% of ESD sites. In this study, we aimed to verify locations at which it is feasible to perform TU-ESD in the upper gastric body and to demonstrate the safety of TU-ESD in single-basin lymph node dissection (SBLND).

Methods: In vitro, TU-ESD was performed at three lesion sites (anterior wall, AW; posterior wall, PW; and lesser curvature, LC) in each porcine stomach using an EASIE-R tray (cases = 10). Read More

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http://dx.doi.org/10.1007/s00464-019-06801-2DOI Listing

Benign Gastric Ulcer with Epstein-Barr Virus Infection Mimicking Malignant Gastric Ulcer.

Korean J Gastroenterol 2019 Mar;73(3):177-181

, National Police Hospital, Seoul, Korea.

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal pain are non-specific and rarely encountered, which means it is difficult to diagnose gastric involvement of EBV infection without suspicion. The relation between gastric carcinoma and gastric lymphoma associated with EBV infection is well defined, but relations with other EBV-associated gastrointestinal diseases such as gastritis and peptic ulcer disease have rarely been reported. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.3.177DOI Listing

Gastroprotective activity of Loranthus acaciae flower extract in a rodent model of ethanol-induced ulcer.

Appl Physiol Nutr Metab 2019 Apr 22. Epub 2019 Apr 22.

University of Jordan, 54658, Amman, Jordan ;

Loranthus acaciae (Loranthaceae) is a perennial green semi-parasitic plant used in ethnopharmacological medicine for healing wounds. The protective effect of L. acaciae on gastric ulcer induced by ethanol was investigated in a rat model. Read More

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http://dx.doi.org/10.1139/apnm-2019-0166DOI Listing

[Characteristics analysis of early gastric cancer under white light endoscopy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):302-306

Department of gastroenterology,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate endoscopic features of early gastric cancer and clinical features of the patients, which may be helpful to provide reasonable suggestions for physicians to diagnose early gastric cancer during preliminary screening of white light gastroscopy.

Methods: A total of 271 patients who received endoscopic submucosal dissection or surgical operation to confirm early gastric cancer in Peking University Third Hospital from Apr. 2009 to Jun. Read More

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April 2019
2 Reads

Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.

Dig Endosc 2019 Apr;31 Suppl 1:4-20

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Prevention therapy is recommended for lesions >1/2 of the esophageal circumference. Locoregional steroid injection is recommended for lesions >1/2-3/4 of the esophageal circumference and oral steroids are recommended for lesions >1/2 of the subtotal circumference. For lesions of the entire circumference, oral steroid combined with injection steroid is considered. Read More

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http://dx.doi.org/10.1111/den.13388DOI Listing
April 2019
2 Reads

(-)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells.

Eur J Pharmacol 2019 Apr 13;854:139-148. Epub 2019 Apr 13.

Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.

The gastroprotective property of (-)-myrtenol, a monoterpenoid, has been demonstrated previously against acute gastric ulceration induced by ethanol. However, the healing property of (-)-myrtenol in a chronic gastric ulcer model remains to be verified. This study evaluated its healing efficacy and the mechanism involved using the rat model of chronic gastric ulcer induced by serosal injection of 80% acetic acid in vivo, and human gastric adenocarcinoma cells (AGS) in vitro. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.025DOI Listing
April 2019
1 Read

Polysaccharide-Rich Extract of Attenuates Water Immersion Stress and Forced Swimming Fatigue in Rodent Animal Model.

J Med Food 2019 Apr;22(4):355-364

4 Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, Korea.

Our study aimed to investigate the effects of the polysaccharide-rich extract of (PEP) against water immersion restraint (WIR) stress and forced swimming-induced fatigue. Exposure to WIR stress significantly increased the ulcer index, bleeding score, the weight of the adrenal gland, blood glucose concentrations, total cholesterol, cortisol, and creatine kinase (CK). The weight of the spleen decreased significantly. Read More

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http://dx.doi.org/10.1089/jmf.2018.4218DOI Listing

In Vivo Gastroprotective and Antidepressant Effects of Iridoids, Verbascoside and Tenuifloroside from Benth.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec, Morelos C.P. 62790, Mexico.

Stress is an important factor in the etiology of some illnesses such as gastric ulcers and depression. Benth. (Orobanchaceae) is used in Mexican traditional medicine for the treatment of gastrointestinal diseases and nervous disorders. Read More

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https://www.mdpi.com/1420-3049/24/7/1292
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http://dx.doi.org/10.3390/molecules24071292DOI Listing
April 2019
2 Reads

Prevalence and Risk Factors of Infection among Children Aged 1 to 15 Years at Holy Innocents Children's Hospital, Mbarara, South Western Uganda.

J Trop Med 2019 7;2019:9303072. Epub 2019 Mar 7.

Mbarara University of Science and Technology, Faculty of Medicine, Department of Medical Laboratory Sciences, P.O. Box 1410, Mbarara, Uganda.

Background: infection affects more than half of the world's population. The infection is generally acquired during childhood but can remain asymptomatic, with long-term clinical sequelae including gastritis, peptic ulcer disease, and stomach cancer.

Methods: The study was approved by Institutional Review Committee of Mbarara University of Science and Technology. Read More

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http://dx.doi.org/10.1155/2019/9303072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431523PMC
March 2019
1 Read

Effects of Feeding Frequency Using a Commercial Automated Feeding Device on Gastric Ulceration in Exercised Quarter Horses.

J Equine Vet Sci 2018 May 16;64:96-100. Epub 2018 Feb 16.

Department of Animal Sciences, Colorado State University, Fort Collins, CO.

The objective of this study was to evaluate two feeding regimens: traditional grain feeding (twice a day, traditional fed [TF]) compared with horses fed with an automated feeder programmed to deliver grain in 20 equal aliquots (fractioned fed [FF]) and its effects on gastric ulceration, body weight, and body condition score (BCS). Thirty-one Quarter Horses were maintained in individual stalls during the 60-day experimental period and worked at moderate exercise intensity. Gastroscopies were performed before grain adaptation at 0, 30, and 60 days. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.02.005DOI Listing
May 2018
1 Read

[A case of Crohn's disease complicated by Guillain-Barrè syndrome during ustekinumab therapy].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):324-329

Coloproctology Center Matsushima Hospital.

We herein report a case involving a 23-year-old male patient with active Crohn's disease complicated by Guillain-Barrè syndrome during ustekinumab therapy. At age 11, the patient developed an anal fistula and was found to have multiple aphthae on the rectosigmoid colon, for which he was diagnosed with Crohn's disease. At age 12, he underwent gastrojejunal anastomosis for pyrolic stenosis. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.324DOI Listing
January 2019
1 Read

Molecular docking of natural phenolic compounds for screening of urease inhibitors.

Curr Pharm Biotechnol 2019 Apr 9. Epub 2019 Apr 9.

International Institute of Pharmaceutical Sciences, Sonepat, Haryana. India.

Bacterial ureases have been the cause of various human and animal pathogenicity including hepatic encephalopathy, hepatic coma urolithiasis, gastric and peptic ulcers, pyelonephritis, and urinary catheter encrustation by production of ammonia. Hence in view of the side effects of existing drugs, there is a strong need to discover, more safe, effective and potent compounds for treatment of infections caused by urease. For this purpose, several natural phenolic compounds have been screened by molecular modelling techniques. Read More

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http://dx.doi.org/10.2174/1389201020666190409110948DOI Listing
April 2019
5 Reads
2.511 Impact Factor

Duration of Treatment Effect Should Be Considered in the Design and Interpretation of Clinical Trials: Results of a Discrete Choice Experiment.

Med Decis Making 2019 Apr 8:272989X19841877. Epub 2019 Apr 8.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Botnar Research Centre, Windmill Road, Headington, Oxford, UK.

Objective: This study examined whether duration of treatment effect should be considered in a benefit-risk assessment using a case study of osteoarthritis medications.

Study Design And Setting: A discrete choice experiment was completed by 300 residents of the United Kingdom with hip and/or knee osteoarthritis. In 16 choice tasks, participants selected their preferred option from 2 medications. Read More

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http://dx.doi.org/10.1177/0272989X19841877DOI Listing
April 2019
1 Read

Chemical composition and protective role of (L.) C.A. Mey. subsp. against gastric ulcer induced by ethanol in rats.

Heliyon 2019 Mar 20;5(3):e01359. Epub 2019 Mar 20.

Clinical Pathology Laboratory, Cairo Specialized Hospital, Cairo, Egypt.

subsp. (Family; Asteraceae) is a medicinal plant used to treat inflammation. The objective of this study is to explore the protective effect of the ethanol extract of subsp. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431749PMC
March 2019
2 Reads

Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.

J Mol Biol 2019 Apr 4. Epub 2019 Apr 4.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Helicobacter pylori colonizes the human stomach and contributes to the development of gastric cancer and peptic ulcer disease. H. pylori secretes a pore-forming toxin called vacuolating cytotoxin A (VacA), which contains two domains (p33 and p55) and assembles into oligomeric structures. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.03.029DOI Listing
April 2019
2 Reads

Anti-inflammatory activities of Canarium subulatum Guillaumin methanol extract operate by targeting Src and Syk in the NF-κB pathway.

J Ethnopharmacol 2019 Apr 2;238:111848. Epub 2019 Apr 2.

Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Canarium subulatum Guillaumin is an herbal medicinal plant native to Southeast Asia. Ethnopharmacological evidence suggests that plants of the genus Canarium cure a variety of inflammatory diseases.

Aim Of The Study: The pharmacological mechanisms of C. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111848DOI Listing
April 2019
5 Reads

Correlation among fecal indicator bacteria and physicochemical parameters with the presence of Helicobacter pylori DNA in raw and drinking water from Bogotá, Colombia.

Helicobacter 2019 Apr 4:e12582. Epub 2019 Apr 4.

Science Faculty, Microbiology Department, Pontificia Universidad Javeriana, Bogotá, Colombia.

Background: The quality of raw and drinking water is a matter of considerable concern due to the possibility of fecal contamination. To assess the quality and public health risk of different types of water, the fecal indicator bacteria (FIB) are used. However, some pathogens, such as Helicobacter pylori, may be present in water when FIB cannot be found. Read More

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http://dx.doi.org/10.1111/hel.12582DOI Listing
April 2019
2 Reads

Rosmarinic Acid Enriched Fraction from Leaves Strongly Protects Indomethacin-Induced Gastric Ulcer in Rats.

Biomed Res Int 2019 4;2019:9514703. Epub 2019 Mar 4.

Division of Biochemistry, School of Medical Sciences, University of Phayao, 56000 Phayao, Thailand.

Gastric ulcers are a common problem in upper gastrointestinal tract (GI) disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most aggressive factors leading to inducing gastric ulcers. Natural products with lower toxicity and safety are currently sought as a potential source to minimize the effect of the gastric ulcers. Read More

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http://dx.doi.org/10.1155/2019/9514703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425344PMC
March 2019
2 Reads

CT findings and clinical features of Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma.

Medicine (Baltimore) 2019 Apr;98(14):e14839

Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Epstein-Barr virus (EBV)-associated lymphoepithelioma-like gastric carcinoma (LELGC) is a rare primary stomach tumor, which has overlapping imaging features with mass forming gastric carcinoma (GC). The aim of our study was to present the computed tomography (CT) findings and clinical features of EBV-associated LELGC to increase awareness of this entity.The CT findings and clinical features of 4 patients with pathologically documented EBV-associated LELGC were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014839DOI Listing
April 2019
2 Reads

Upper gastrointestinal bleeding in Egyptian patients with cirrhosis: Post-therapeutic outcome and prognostic indicators.

J Gastroenterol Hepatol 2019 Mar 14. Epub 2019 Mar 14.

Hepatology Department, National Liver Institute, University of Menoufia, Shebeen El-Kom, Egypt.

Background And Aim: Upper gastrointestinal bleeding (UGIB) is a serious complication of portal hypertension in cirrhotic patients. The objective of this study is to identify the risk factors for morbidity and mortality occurring after an UGIB attack.

Methods: A total of 1097 UGIB attacks in 690 patients with liver cirrhosis were studied. Read More

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http://dx.doi.org/10.1111/jgh.14659DOI Listing
March 2019
1 Read

In Vitro and Activities of Zinc Linolenate, a Selective Antibacterial Agent against .

Antimicrob Agents Chemother 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China

is a major global pathogen and its infection represents a key factor in the etiology of various gastric diseases including gastritis, peptic ulcers and gastric carcinoma. The efficacy of current standard treatment for infection including two broad-spectrum antibiotics is compromised by toxicity toward gut microbiota and development of drug resistance, which will likely only be resolved through novel and selective antibacterial strategies. Here, we synthesized a small molecule, Zinc linolenate (ZnLla), and investigated its therapeutic potential for the treatment of infection. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.00004-19
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http://dx.doi.org/10.1128/AAC.00004-19DOI Listing
April 2019
4 Reads

Blockade of Cardiac Proton Pump Impairs Ventricular Remodeling Through a Superoxide-DDAH-Dependent Pathway in Infarcted Rats.

Acta Cardiol Sin 2019 Mar;35(2):165-178

Cardiovascular Institute.

Background: Proton pump inhibitors (PPIs) are frequently used to prevent or treat peptic ulcers. Recently, PPIs have been shown to increase the risk of myocardial infarction. The purpose of this study was to determine whether PPIs adversely affect ventricular remodeling in infarcted rats. Read More

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http://dx.doi.org/10.6515/ACS.201903_35(2).20180917ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434409PMC
March 2019
0.845 Impact Factor

[Clinical Pharmaceutical Research Based on New Proteome Analysis Based on Chromatographic Separation].

Authors:
Kaname Ohyama

Yakugaku Zasshi 2019 ;139(4):505-509

Graduate School of Biomedical Sciences, Nagasaki University.

Comprehensive identification of antigens in immune complexes (IC-antigens) is beneficial to provide insights into pathophysiology and could form the basis for novel diagnostic and treatment strategies for many immune-related diseases. Immune complexome analysis is a method for comprehensively identifying and profiling IC-antigens in biological fluids (such as serum and cerebrospinal fluid). We applied this strategy to the analysis of circulating ICs in autoimmune diseases (rheumatoid arthritis, Sjögren's syndrome, systemic scleroderma, and systemic lupus erythematosus), infectious diseases, and cancers. Read More

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https://www.jstage.jst.go.jp/article/yakushi/139/4/139_18-00
Publisher Site
http://dx.doi.org/10.1248/yakushi.18-00167DOI Listing
April 2019
6 Reads

Limb Length in Gastric Bypass in Super-Obese Patients-Importance of Length of Total Alimentary Small Bowel Tract.

Obes Surg 2019 Mar 30. Epub 2019 Mar 30.

Aleris Obesity Clinic and Department of Surgery, Aleris Hospital, Fredrik-Stangsgate 11-13, 0264, Oslo, Norway.

Background: In super-obese patients, rates of weight loss failure and weight regain are high after RYGB. In order to improve weight loss, lengthening of the biliopancreatic limb is vital. In this study, efficacy and safety of two types of RYGB with 2-m BP-limb were assessed in improving weight loss and in the resolution of comorbidities compared with standard RYGB in a long-term follow-up. Read More

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http://dx.doi.org/10.1007/s11695-019-03836-1DOI Listing
March 2019
2 Reads

Primary acquired gastric outlet obstruction in children: A retrospective single center study.

J Pediatr Surg 2019 Mar 15. Epub 2019 Mar 15.

Dept. of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Aligarh Muslim University, UP, India.

Background/ Purpose: Idiopathic hypertrophic pyloric stenosis is by far the most common cause of gastric outlet obstruction (GOO) in young infants, with more than 90% of cases presenting between 3 and 10 weeks after birth. While cases of late onset pyloric stenosis beyond infancy have been reported, the etiology is poorly understood. We report our experience of 5 cases, describing the similarities and differences in management of our patient population which happens to be the second largest reported in literature. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.056DOI Listing

Clinicopathological features of duodenal bulb biopsies and their relationship with upper gastrointestinal diseases.

Ann Diagn Pathol 2019 Feb 10;40:40-44. Epub 2019 Feb 10.

Department of Gastroenterology, Peking University Third Hospital, 49 Rd. Garden, Haidian District, Beijing, PR China.

Aim: To assess the prevalence of the lesions in duodenal bulb mucosa and the relationship between duodenal lesions and upper gastrointestinal diseases, including helicobacter pylori infection.

Methods: Clinical, endoscopic and pathological data of the cases with duodenal bulb and gastric mucosal biopsy from January 2005 to May 2017 were analyzed retrospectively.

Results: A total of 3540 patients were enrolled. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.006DOI Listing
February 2019
2 Reads

Response to: Comment on "Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study".

Gastroenterol Res Pract 2019 24;2019:9214597. Epub 2019 Feb 24.

Pathological Department, Emergency County Hospital, Gheorghe Marinescu 50, Tirgu Mures, 540136 Mures, Romania.

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http://dx.doi.org/10.1155/2019/9214597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409013PMC
February 2019
1 Read

Cost-effectiveness analysis and effectiveness of pharmacist-managed outpatient clinics in Helicobacter pylori eradication therapy.

Int J Clin Pract 2019 Mar 26:e13349. Epub 2019 Mar 26.

Laboratories of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.

Background: Helicobacter pylori is involved in many upper gastrointestinal diseases such as peptic ulcers and gastric cancers. In this study, we compared the cost-effectiveness of lansoprazole and vonoprazan in H. pylori eradication therapy and examined the effectiveness of pharmacist-managed outpatient clinics. Read More

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http://dx.doi.org/10.1111/ijcp.13349DOI Listing

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders.

Int J Mol Sci 2019 Mar 24;20(6). Epub 2019 Mar 24.

Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.

Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett's esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. Read More

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https://www.mdpi.com/1422-0067/20/6/1477
Publisher Site
http://dx.doi.org/10.3390/ijms20061477DOI Listing
March 2019
8 Reads

Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. A short review.

Infect Dis (Lond) 2019 Mar 25:1-10. Epub 2019 Mar 25.

b Unit of Gastroenterology , Molinette-SGAS Hospital , Turin , Italy.

Helicobacter pylori is a human-specific pathogen with a strict tropism for the gastric mucosa. This bacterium infects around half of the world population and is the main responsible for gastritis, peptic ulcer and, in some cases, for the pathogenesis of gastric cancer. Nevertheless, disease development in infected subjects depends not only on the bacterium, but also on the host genetic predisposition and on environmental factors. Read More

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http://dx.doi.org/10.1080/23744235.2019.1588472DOI Listing
March 2019
3 Reads

Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury in Experimental Sprague-Dawley Rats.

Biomed Res Int 2019 17;2019:8759708. Epub 2019 Feb 17.

Lee's Biotech Co., Korea Research Institute of Bioscience and Biotechnology, BVC #202, Daejeon 34141, Republic of Korea.

(black raspberry, RF), (elm, UL), and (cape jasmine, GJ) are well known for hundreds of years as folk medicines in China and Korea to treat various gastrointestinal disturbance. The present study evaluated the gastroprotective effects of these plants either single or in combination against HCl/EtOH-induced gastritis and indomethacin-induced ulcer in rat model. Stomach ulcer was induced by oral ingestions of HCl/EtOH or indomethacin. Read More

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http://dx.doi.org/10.1155/2019/8759708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398063PMC
February 2019
1 Read

Gastroprotective Effects of Paeonia Extract Mixture HT074 against Experimental Gastric Ulcers in Rats.

Evid Based Complement Alternat Med 2019 17;2019:3546258. Epub 2019 Feb 17.

Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Republic of Korea.

Background: Paeonia extract mixture HT074 is a standardized multiherbal mixture comprising extracts from flowers and roots, which are used to treat digestive disorders in traditional Korean medicine. This study was focused on elucidating the underlying mechanisms of the gastroprotective effects of HT074 in different gastric ulcer models.

Methods: Gastric lesions were induced in rats by an HCl/EtOH solution, water immersion-restraint stress (WIRS), and indomethacin. Read More

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http://dx.doi.org/10.1155/2019/3546258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398042PMC
February 2019
1 Read

High-performance liquid chromatographic analysis explores the potential antioxidative agents of ARN. EX CHOISY extract.

J Pharm Bioallied Sci 2019 Jan-Mar;11(1):16-22

Institute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research, Dhaka 1205, Bangladesh.

Background: Antioxidative properties of medicinal plants play the key role in plant defense mechanism. is an evergreen shrub which is used in the treatment of boils, gastric ulcers, tumor, marasmus, paralysis and spermatorrhea, rheumatoid arthritis, cold, painful sensation, and fever.

Aims: This research investigates the phytochemical contents and antioxidative effects of optimized crude methanol extract of . Read More

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http://dx.doi.org/10.4103/jpbs.JPBS_252_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394157PMC
March 2019
1 Read

Multilocus Heterotopic Gastric Mucosa of Ileum Masquerading as VEOIBD in a Newborn.

Pediatrics 2019 Apr;143(4)

Divisions of Gastroenterology and

Heterotopic gastric mucosa (HGM) is defined as the presence of gastric mucosa outside of the stomach, which is documented by histologic finding. HGM is typically a solitary lesion; however, in our Case Report, the patient presented with multilocus HGM, an uncommon form in which the small bowel is extensively involved. We report a unique case of multilocus HGM mimicking very early-onset inflammatory bowel disease with recurrent gastrointestinal bleeding, chronic inflammation, and stricturing in a newborn patient. Read More

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http://dx.doi.org/10.1542/peds.2018-2398DOI Listing
April 2019
1 Read

Gastric ulcers in an HIV untreated patient.

Clin Microbiol Infect 2019 Mar 18. Epub 2019 Mar 18.

Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Centre, Jerusalem, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193010
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http://dx.doi.org/10.1016/j.cmi.2019.02.031DOI Listing
March 2019
4 Reads
5.768 Impact Factor

Effects of tegoprazan, a novel potassium-competitive acid blocker, on rat models of gastric acid-related disease.

J Pharmacol Exp Ther 2019 Mar 20. Epub 2019 Mar 20.

R&D Institute, CJ HealthCare corp.

Tegoprazan, a novel potassium-competitive acid blocker (P-CAB), is next generation therapeutics in development for acid-related gastrointestinal diseases such as gastroesophageal reflux disease (GERD) and peptic ulcers. In the present study, the in vitro and in vivo pharmacological properties of tegoprazan are compared with those of esomeprazole, a representative proton pump inhibitor. In vitro enzyme assays were performed using the ion-leaky vesicles containing gastric H+/K+-ATPases isolated from porcine. Read More

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http://dx.doi.org/10.1124/jpet.118.254904DOI Listing
March 2019
9 Reads

A Bleeding Dieulafoy's Lesion in the Anal Canal.

Cureus 2019 Jan 8;11(1):e3853. Epub 2019 Jan 8.

Gatsroenterology, Staten Island University Hospital, Northwell Health, Staten Island, USA.

Dieulafoy's lesion (DL) is a dilated aberrant submucosal vessel that erodes through the overlying epithelium in the absence of a primary ulcer. It is a known cause of gastrointestinal (GI) bleeding and commonly located in the lesser curvature of the stomach, but it is rare in the anal canal. We report a unique case of a middle-aged man presenting with lower GI bleeding secondary to an anal DL diagnosed by colonoscopy, managed successfully with endoscopic hemoclips. Read More

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http://dx.doi.org/10.7759/cureus.3853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411322PMC
January 2019
4 Reads

VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection.

MBio 2019 03 19;10(2). Epub 2019 Mar 19.

Institute of Molecular Cancer Research, Zurich, Switzerland

The gastric bacterium causes a persistent infection that is directly responsible for gastric ulcers and gastric cancer in some patients and protective against allergic and other immunological disorders in others. The two outcomes of the -host interaction can be modeled in mice that are infected as immunocompetent adults and as neonates, respectively. Here, we have investigated the contribution of the immunomodulator VacA to -specific local and systemic immune responses in both models. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00261-19
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http://dx.doi.org/10.1128/mBio.00261-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426600PMC
March 2019
4 Reads

Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice.

Food Res Int 2019 May 22;119:751-760. Epub 2018 Oct 22.

Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Federal University of Espirito Santo, Vitoria, ES, Brazil. Electronic address:

The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide. Persea americana Mill. (avocado) seed is a by-product generally discarded as waste, but can be used to treat gastric disorder due to its anti-inflammatory, antioxidant and antimicrobial activities. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.10.057DOI Listing
May 2019
1 Read

A Novel Gastric Spheroid Co-culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium.

Cell Mol Gastroenterol Hepatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Microbiology and Immunology, Montana State University, Bozeman, Montana. Electronic address:

Background & Aims: Gastric dendritic cells (DCs) control the adaptive response to infection with Helicobacter pylori, a major risk factor for peptic ulcer disease and gastric cancer. We hypothesize that DC interactions with the gastric epithelium position gastric DCs for uptake of luminal H pylori and promote DC responses to epithelial-derived mediators. The aim of this study was to determine whether the gastric epithelium actively recruits DCs, using a novel co-culture model of human gastric epithelial spheroids and monocyte-derived DCs. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.02.010DOI Listing
March 2019
4 Reads

Computed tomographic characteristics of gastric schwannoma.

J Int Med Res 2019 Mar 14:300060519833539. Epub 2019 Mar 14.

1 Department of Radiology, Fudan University Shanghai Cancer Center (FUSCC), Shanghai, PR China.

Objective: This study aimed to characterize the computed tomographic (CT) features of gastric schwannoma (GS).

Methods: We retrospectively reviewed CT images of 19 cases of histologically proven GS between January 2010 and December 2015. Tumor location, size, contour, margin, growth pattern, and degree and pattern of enhancement, perigastric lymph nodes, ulceration, necrosis, and calcification were evaluated. Read More

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http://dx.doi.org/10.1177/0300060519833539DOI Listing
March 2019
4 Reads

A Comprehensive Review On the Screening Models for The Pharmacological Assessment of Antiulcer Drugs.

Curr Clin Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Department Pharmacy, Pranveer Singh Institute of Technology Address: Kanpur - Agra - Delhi National Highway -2, Bhauti, Kanpur, Uttar Pradesh 209305. India.

Background: Due to inappropriate diet, smoking, alcohol consumption, regular use of drugs like NSAIDs, sedentary lifestyle, one may feel upper abdominal pain which may be the predictor of the gastrointestinal disorder called Peptic Ulcer. When an imbalance occurs between the defensive factor and aggressive factor of the stomach, ulcer formation in the esophageal lining, stomach, or duodenum takes place. This leads to the formation of small sores that causes pain. Read More

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http://dx.doi.org/10.2174/1574884714666190312143846DOI Listing
March 2019
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Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):63-68

University Children's Hospital, Medical Faculty Skopje, Republic of Macedonia.

Introduction: The term angiodysplasia (AD) refers to acquired malformation of the blood vessels (communications between veins and capillaries), frequently found within the gastrointestinal mucosa and submucosa. AD of stomach and duodenum are cause of upper gastrointestinal bleeding in 4%-7% of patients. The means of treatment are usually endoscopic, including argon plasma coagulation (APC), electrocoagulation, mechanical hemostasis by clippsing, laser photo-coagulation and injection therapy. Read More

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https://content.sciendo.com/view/journals/prilozi/39/2-3/art
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http://dx.doi.org/10.2478/prilozi-2018-0043DOI Listing
December 2018
3 Reads

Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats.

Medicina (Kaunas) 2019 Mar 11;55(3). Epub 2019 Mar 11.

Department of Pharmacology, Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran.

Zingerone is an ingredient of ginger () with different pharmacological activities. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea. This study is aimed to evaluate the effect of zingerone on ethanol-induced gastric ulcers in rats. Read More

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http://dx.doi.org/10.3390/medicina55030064DOI Listing
March 2019
3 Reads

Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial.

Medicine (Baltimore) 2019 Mar;98(10):e14637

Kuwana City Medical Center, Kuwana.

Background: Polaprezinc is clinically used for the treatment of gastric ulcers. It induces the mobilization of mesenchymal stem cells and the mRNA expression of insulin-like growth factor-1 in vascular endothelial cells in order to protect injured gastric tissue or skin.

Methods: The current study population included 50 patients with primary acute myocardial infarction (AMI). Read More

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http://dx.doi.org/10.1097/MD.0000000000014637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417532PMC
March 2019
1 Read

From germ theory to germ therapy.

Kaohsiung J Med Sci 2019 Feb;35(2):73-82

Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Germ theory of disease and Koch's postulates has been governing our understanding of the role of microbes in human health since 19th century. The discovery of Helicobacter pylori (H. pylori) and H. Read More

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http://dx.doi.org/10.1002/kjm2.12011DOI Listing
February 2019
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Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins.

Mucosal Immunol 2019 05 7;12(3):784-794. Epub 2019 Mar 7.

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 41390, Sweden.

Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the gastric mucosa of 60-95% of pigs at slaughter age, and is associated with chronic gastritis, decreased weight gain, and ulcers. Read More

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http://dx.doi.org/10.1038/s41385-019-0154-4DOI Listing
May 2019
2 Reads