Search Our Scientific Publications & Authors

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

Pak J Pharm Sci 2019 Jan;32(1):7-13

Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.

Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits. The ulcer was induced by oral administration of aspirin in all groups except normal control group. Gastric contents were used to estimate total acid output, gastric volume and gastric pH. Read More

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

H.E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research (P.C.M.D.), International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

Ethnopharmacological Relevance: Tetrapleura tetrapteura Taub. is a leguminous multipurpose tree (Fabaceae) indigenous to tropical Africa. Fruits, seeds and stem bark infusions or decoctions of Tetrapleura tetrapteura Taub. Read More

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Gastrointestinal complications, including hemorrhage, can occur with intracranial lesions and after craniotomy. As early as the 19th century, surgeons were aware that brain tumors could cause gastric ulcers and acute perforations. Investigators used animal experiments both to reproduce these clinical observations and to seek ways to block the effects. Read More

BMC Pharmacol Toxicol 2019 Feb 15;20(1):13. Epub 2019 Feb 15.

Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Basic function of bromine in body is to activate pepsin production in gastritis with low acidity. The present study encompasses a broad in vivo study to evaluate gastroprotective activity of a novel dibromo substituted Schiff base complex against Sprague Dawley (SD) rats.

Methods: 2, 2'-[1, 2-cyclohexanediylbis (nitriloethylidyne)]bis(4-bromophenol) (CNBP) is synthesized via a Schiff base reaction, using the related ketone and diamine as the starting materials. Read More

VideoGIE 2019 Feb 7;4(2):91-94. Epub 2018 Dec 7.

Division of Gastroenterology and Hepatology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Background And Aims: GI tract perforations and anastomotic dehiscence are increasingly effectively being repaired endoscopically; however, well-known and long-held surgical principles must still be honored. One important principle is that significant extraluminal contamination must be washed out, debrided, and drained in conjunction with repair of the defect if the wound is to effectively heal and resolve. Here we describe the use of endoscopic washout and debridement of extraluminal contamination at the time of luminal defect closure in a 7-patient series at our institution, with video demonstration of 2 patients in the series. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):178-180

Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.

A 72-year-old man with general fatigue was referred, and CT and MRI revealed a pancreatic mass with necrosis that was suspected of invading the stomach, splenic artery, celiac artery, liver, and portal vein. Upper gastrointestinal endoscopy showed an extrinsic mass with ulcer formation in the posterior wall of the upper gastric corpus and irregular mucosa in the lower esophagus incidentally. Biopsy showed squamous cell carcinoma from both lesions, leading to the diagnosis of pancreatic adenosquamous carcinoma and early esophageal cancer. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):100-102

Dept. of Surgery, Suita Municipal Hospital.

A 78-year-oldwoman was referredfor exertional dyspnea. Severe anemia(Hb 4.2 g/dL)was detected, and upper endoscopy revealeda giant ulcer at the posterior wall of the gastric body. Read More

J Ethnopharmacol 2019 Feb 11;235:183-189. Epub 2019 Feb 11.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP ZIP 14801-902, Brazil. Electronic address:

Ethnopharmacological Relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use.

Aim Of Study: Considering the potential of copalic (CA) and kaurenoic acid (KA) - major biological activity (in vitro) diterpenes found in the oleoresin, this study aimed to evaluate the intestinal permeability of CA and KA using Caco-2 cells model as predictive test for oral drug absorption.

Materials And Methods: Chemical stability at pH 1. Read More

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Physiology, Biosciences Institute, UNESP-São Paulo State University CEP 18618-689, Botucatu, São Paulo, Brazil. Electronic address:

Ethnopharmacological Relevance: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. Read More

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.

Background: Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications.

Aim: To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding.

Methods: Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed to build a model (IPU-ML) to predict recurrent ulcer bleeding. Read More

Molecules 2019 Feb 11;24(3). Epub 2019 Feb 11.

Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Santo Tomás, Delegación Miguel Hidalgo, Ciudad de México 11340, Mexico.

Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from ), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0. Read More

Biochem Pharmacol 2019 Feb 10;163:71-83. Epub 2019 Feb 10.

Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland. Electronic address:

Background And Purpose: Besides hydrogen sulfide (HS) and nitric oxide (NO), carbon monoxide (CO) contributes to the maintenance of gastric mucosal integrity. We investigated increased CO bioavailability effects on time-dependent dynamics of gastric ulcer healing mediated by particular growth factors, anti-inflammatory and molecular pathways.

Experimental Approach: Wistar rats with gastric ulcers induced by serosal acetic acid application (day 0) were treated i. Read More

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Objective: Capsule endoscopy (CE) is a noninvasive diagnostic tool for the digestive tract. We aim to investigate the feasibility and safety of newly-developed magnetically controlled capsule endoscopy (MCE) in children.

Methods: A total of 129 children who underwent MCE in Shanghai Children's Hospital were retrospectively recruited between March 2016 and August 2018. Read More

Int J Surg Case Rep 2019 Feb 1;55:156-159. Epub 2019 Feb 1.

Department of General Surgery, Fatebenfratelli Hospital, Piazzale Principessa Clotilde, 3, 20121, Milano, MI, Italy. Electronic address:

Introduction: Roux-an-Y gastric bypass (RYGP) is one of the most important bariatric procedures and its results are well known in terms of weight loss and comorbid improvement. The major limitation of this technique is the difficult exploration of the excluded stomach and duodenum. Some Authors are performing the gastric bypass with fundectomy and, according to Literature, it is feasible and effective, with major advantage of explorable gastric pouch. Read More

Int J Biol Macromol 2019 Feb 6;129:233-245. Epub 2019 Feb 6.

Institut für Chemie/Physikalische Chemie der Polymere, Von-Danckelmann-Platz 4, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.

Oral drug delivery is natural, most acceptable and desirable route for nearly all drugs, but many drugs like NSAIDs when delivered by this route cause gastrointestinal irritation, gastric bleeding, ulcers, and many undesirable effects which limits their usage by oral delivery. Moreover, it is almost impossible to control the release of a drug in a targeted location in body. We developed thermo-responsive chitosan-co-poly(N-isopropyl-acrylamide) injectable hydrogel as an alternative for the gastro-protective and controlled delivery of loxoprofen sodium as a model drug. Read More

Evid Based Complement Alternat Med 2019 3;2019:7365841. Epub 2019 Jan 3.

School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040, China.

Jinlingzi powder comprises . and and is usually applied in clinic as traditional Chinese medicine for pain. The present study aims to investigate the therapeutic actions of Jinlingzi powder and its extracted components and theirs treatment mechanism on the acetic acid induced-gastric ulcer in rats. Read More

J Clin Med 2019 Feb 3;8(2). Epub 2019 Feb 3.

Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.

Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) and infection are the two major factors disrupting the mucosal resistance to injury. Read More

J Ethnopharmacol 2019 Jan 30;235:100-110. Epub 2019 Jan 30.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region; State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region. Electronic address:

Ethnopharmacological Relevance: Dual antiplatelet therapy (DAPT) with aspirin (ASA) and clopidogrel (CLP) has been consistently shown clinical effectiveness in patients with coronary artery disease. According to the literature, four traditional Chinese medicine (TCM) herbs effective for prevention cardiovascular diseases, namely Radix Salvia Miltiorrhiza (Red sage root, Danshen), Radix Pueraria Lobata (Kudzu root, Gegen), Radix Angelica Sinensis (Angelica root, Danggui), and Rhizoma Ligusticum chuanxiong (Szehuan lovage rhizome, Chuanxiong), are of high potential to be co-administered during DAPT. Since all these herbs are blood vitalizing medicines and can promote blood circulation and eliminate blood stasis, it was hypothesized that they may potentially alter the clinical outcomes of DAPT with clopidogrel and aspirin. Read More

Ter Arkh 2018 Aug;90(8):33-39

A.I. Evdokimov Moscow State Medicine and Dentistry, University of the Ministry of Health of Russia, Moscow, Russia.

Aim: The aim is to conduct a comprehensive comparative study of the efficacy and safety of the hybrid scheme of eradication therapy (ET) in patients with peptic ulcer of the stomach or duodenum associated with Helicobacter pylori.

Materials And Methods: Materials and methods. In a prospective, randomized comparative study, 180 patients were divided into three equal groups of 60 people, depending on the prescribed 10-day ET regimen. Read More

Ter Arkh 2018 Aug;90(8):27-32

A.I. Evdokimov Moscow State Medicine and Dentistry, University of the Ministry of Health of Russia, Moscow, Russia.

Aim: To evaluate the effectiveness and safety of the use of rebamipide as part of the triple eradication therapy (ET) scheme of Helicobacter pylori infection.

Materials And Methods: A prospective, randomized comparative study included 94 patients with uncomplicated H. pylori-associated stomach / duodenal ulcer. Read More

Ter Arkh 2018 May;90(5):50-54

N.N. Burdenko Main Military Clinical Hospital of the Ministry of Defense, Moscow, Russian.

Aim: To assess the frequency of ulceration and erosion in patients with rheumatic diseases (RD) receiving NSAIDs, depending on the concomitant use of GC.

Materials And Methods: A retrospective comparison was made of the incidence of gastrointestinal lesions detected in patients with RD during endoscopic examination in one medical center for 2007-2016. Three groups were formed: in group 1 patients took only NSAIDs (n=4823, women 80. Read More

Ter Arkh 2018 Feb;90(2):28-34

Tver State Medical University, Ministry of Health of Russia, Tver, Russia.

Aim: Find out the calcium content of the blood reflecting its balance and functional status the calcium regulatory system when it is comorbid for gastroduodenal ulcers (GDU), developed on the background of chronic erosive gastritis (CEG), chronic erosive duodenitis (CED), arterial hypertension (AH) and osteo-articular pathology with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the impact of his changes on the activity ulzerogennogo process, the state of regional microcirculation and the functions of the stomach. To determine the pathogenetic justification for and effectiveness of blockers of slow calcium channels (BSCaC) in complex treatment.

Materials And Methods: Examined 132 patients with GDU. Read More

Arch Med Sci 2019 Jan 19;15(1):223-231. Epub 2016 Oct 19.

Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

Introduction: (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress.

Material And Methods: The methanolic extract of PS was prepared in the dose of 500 mg/kg. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2384-2386

Dept. of Surgery, Tokyo Women's Medical University Medical Center East.

We report a case of sigmoid colon cancer that was incidentally found using CT that was performed for upper abdominal pain. An 83-year-old man with a long history of lung tuberculosis and idiopathic pulmonary fibrosis presented with upper abdominal pain. CT findings revealed free gas around the stomach. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2321-2323

Dept. of Surgery, Toyonaka Municipal Hospital.

We report a case of successful control of advanced duodenal cancer with paclitaxel chemotherapy. A woman in her 70s with epigastralgia was diagnosed with hemorrhagic duodenal ulcer upon upper gastrointestinal endoscopy. A type 3 tumor was found in the duodenal bulb upon upper gastrointestinal endoscopy and biopsy at our hospital. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2282-2284

Dept. of General Surgery, Shuuwa General Hospital.

A 62-year-old man presented with complaints of acute abdominal pain. Abdominal enhanced CT showed free air in the abdominal cavity, a thickened stomach wall accompanied by deep ulcer, and enlarged lymph nodes around the stomach. Emergent surgery was conducted, and a perforation in the upper part of the stomach was found. Read More

J Pathol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

In the mammalian stomach, the isthmus has been considered as a stem cell zone. However, various locations and proliferative activities of gastric stem cells have been reported. We focused here on the stem cell marker Bmi1, a polycomb group protein, aiming to elucidate the characteristics of Bmi1-expressing cells in the stomach and to examine their stem cell potential. Read More

Curr Health Sci J 2018 Apr-Jun;44(2):186-191. Epub 2018 Mar 27.

University of Oradea, Faculty of Medicine and Pharmacy.

Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. Read More

BMC Gastroenterol 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Background: The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the region for better management of infections caused by such bacteria.

Methods: Four hundred two gastric biopsy specimens were analyzed using histopathological examination and real time-PCR. Read More

Pharmaceutics 2019 Jan 22;11(2). Epub 2019 Jan 22.

School of Pharmacy, China Medical University, Shenyang 110021, China.

The aim of this study was to investigate the pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule in gastric ulcer rats and beagle dogs in order to confirm whether it is more effective in treating gastric ulcers and its rapid absorption. A rat model of gastric ulcers was used to evaluate the anti-ulcerogenic effect of the compound lansoprazole capsule. A fast and sensitive UPLC-MS/MS method was developed to detect lansoprazole in dog plasma. Read More

J Vet Med Sci 2019 Jan 23. Epub 2019 Jan 23.

Department of Veterinary Physiology, Faculty of Veterinary Science, Chulalongkorn University.

Equine Glandular Gastric Disease (EGGD) is a common disease in sport horses. This disease might be associated with usage of nonsteroidal anti-inflammatory drugs (NSAIDs) for treating inflammatory diseases. Although gastroscopy has been an effective method for diagnosis, but a less invasive, and inexpensive method is preferred. Read More

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):98-104. Epub 2019 Jan 10.

Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.

We report a rare case of Meckel's diverticulum in a boy who initially presented with chronic iron deficiency anemia (IDA) without any history of gastrointestinal (GI) bleeding at 8 years-old. Isolated small bowel Crohn's disease was suspected based on findings of small bowel ulcers on capsule endoscopy. At four years from initial presentation, he developed massive GI bleeding. Read More

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):57-62. Epub 2019 Jan 10.

Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.

Purpose: This study was performed to assess the clinical usefulness of transabdominal ultrasonography (TUS) in detecting peptic ulcer disease (PUD) in children.

Methods: Twenty-four patients (19 boys, 5 girls; mean age, 10.6±4. Read More

Zhonghua Yi Xue Za Zhi 2018 Dec;98(48):3936-3940

Intensive Care Unit, Tongzhou People's Hospital, Nantong 226300, China.

To investigate the effects of nasogastric tube (NGT) and percutaneous endoscopic gastrostomy (PEG) tube feeding on the susceptibility of pulmonary infection in long-term coma patients with stroke or traumatic brain injury. A total of 295 candidates who were in long-term coma after stroke or traumatic brain injury but without pulmonary infection and eligible for PEG catheterization were screened prospectively between January 2014 and February 2018. The patients were divided into PEG group (86 patients) and NGT group (209 patients) according to the choice of next-of-kin. Read More

Phytomedicine 2018 Aug 3;55:31-39. Epub 2018 Aug 3.

Substance Abuse Research Centre, Jazan University, P.O.Box 114, Jazan, Saudi Arabia.

Background: Clausena excavata Burm.f. (Rutaceae) has been used for the treatment of stomach disorders including peptic ulcer. Read More

Phytomedicine 2019 Feb 4;53:37-42. Epub 2018 Sep 4.

Department of Morphology, São Paulo State University (UNESP), Institute of Biosciences, Botucatu, Brazil. Electronic address:

Background: In an increasing search for natural products that may heal the ulcers and avoid its recurrence, limonene appears as a promising candidate.

Hypothesis/purpose: The present study aimed to investigate the protective effect of limonene in ethanol-induced gastric ulcers, in addition, to investigate the involvement of antioxidant and anti-inflammatory activities, besides the modulation of gene expression.

Study Design: Male Wistar rats were orally treated with vehicle (8% tween 80), carbenoxolone (100 mg/kg) or limonene (25, 50 or 100 mg/kg) and then orally received ethanol to induce gastric ulcers formation. Read More

Harefuah 2019 Jan;158(1):21-24

The Surgical Division, Hillel Yaffe Medical Center, Hadera, Israel.

Introduction: Gastrointestinal perforation is a well-known phenomenon among patients presented to emergency rooms. Common causes for perforation are gastric and duodenal ulcers, colon tumors and trauma. Some patients are operated on immediately due to the clear clinical picture of acute abdomen. Read More

J Eur Acad Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Assistance Publique - Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.

Here in, we report a particular case presenting an erythematous and indurated plaque of the neck that has revealed gastric linitis plastic (GLP). An 80-year-old man presented to the Department of Dermatology in November 2015 with a 2-month history of a sclerotic inflammatory infiltration of the skin located on the anterior cervical region (Figure 1a, b) associated with a general impaired condition. Medical history revealed a partial gastrectomy for peptic ulcer 30 years ago. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14158

Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University.

Rationale: Fungal infection of gastrointestinal (GI) tract is usually seen in immunocompromised patients, but can rarely occur in immunocompetent people in whom no permissive factor is present.

Patient Concerns: We describe a 68-year-old male immunocompetent patient presenting with simultaneous fungal esophagitis and giant gastric ulcer.

Diagnoses: Repeated endoscopic biopsies were taken from the giant gastric ulcer edge and base and histology demonstrated granulation tissue and pseudohyphal fungal forms. Read More

Braz J Med Biol Res 2019 Jan 10;52(2):e8103. Epub 2019 Jan 10.

Departamento de Clinica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors. Read More

J Radiol Case Rep 2018 Sep 30;12(9):9-20. Epub 2018 Sep 30.

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

An 81-year-old male presented with loss of appetite, early satiety and iron deficiency anaemia. A computed tomography (CT) scan of the abdomen and pelvis during initial work-up revealed diffuse gastric mural thickening associated with a large ulcer and adjacent gastro-hepatic lymphadenopathy. The CT appearances, together with the clinical features, were highly suspicious for an infiltrative type of gastric malignancy. Read More

Gastroenterol Res Pract 2018 16;2018:8356948. Epub 2018 Dec 16.

Unit of Gastroenterology, Molinette Hospital, Corso Bramante 88, 10126 Turin, Italy.

Cell Microbiol 2019 Jan 15:e13006. Epub 2019 Jan 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Helicobacter pylori (HP) is a Gram-negative bacterium that chronically infects the stomach of more than 50% of human population and represents a major cause of gastric cancer, gastric lymphoma, gastric autoimmunity, and peptic ulcer. It still remains to be elucidated, which HP virulence factors are important in the development of gastric disorders. Here, we analysed the role of the HP protein HP1454 in the host-pathogen interaction. Read More

Case Rep Gastrointest Med 2018 10;2018:2496193. Epub 2018 Dec 10.

Sinai Hospital, Baltimore, Maryland, USA.

Emphysematous gastritis is the infection of gastric mucosa by gas producing microorganisms. It is a rare infection with less than 100 cases reported in the literature. The association of portal venous gas along with emphysematous gastritis is a rare entity. Read More

Evid Based Complement Alternat Med 2018 12;2018:3585394. Epub 2018 Dec 12.

Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Linn. Read More

Diabetes Metab Syndr 2019 Jan - Feb;13(1):116-121. Epub 2018 Aug 23.

Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Obesity represents one of the common medical disorders that carries a high risk of morbidity and mortality. Insertion of intragastric balloon is one of the recently introduced lines of treatment of obesity. It allows patients to sense abdominal fullness and reduce their food intake. Read More