382,478 results match your criteria Gastric Outlet Obstruction


[Cobalamin deficiency in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):309-314. Epub 2018 Dec 12.

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Read More

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October 2018
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Accuracy and Pitfalls in the Assessment of Early Gastrointestinal Lesions.

Dig Dis 2018 Dec 12:1-10. Epub 2018 Dec 12.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Read More

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December 2018
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Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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December 2018

Chitosan-based nanodelivery systems applied to the development of novel triclabendazole formulations.

PLoS One 2018 12;13(12):e0207625. Epub 2018 Dec 12.

Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Münster, Germany.

Triclabendazole is a poorly-water soluble (0.24 μg/mL) compound classified into the Class II/IV of the Biopharmaceutical Classification System. It is the drug of choice to treat fascioliasis, a neglected parasitic disease worldwide disseminated. Read More

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December 2018
1 Read

[Primary gastric choriocarcinoma: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

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December 2018
1 Read

An elderly man with gastric cancer, Saint's triad and Heyde's syndrome.

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):289-292

Armed Forces Hospital. Brasília-DF, Brazil.

This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers. Read More

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December 2018

[Prognostic value of lymph node ratio (LNR) in patients who underwent radical gastrectomy].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):253-260

Departamento de Cirugía Oncológica Abdominal, Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.

The study objective was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer who underwent radical gastrectomy D2.

Materials And Methods: We reviewed retrospectively 498 medical records of patients with gastric cancer who were attended at the National Institute of Neoplastic Diseases (INEN) between 2008 and 2011and met the inclusion and exclusion criteria. They were distributed into 4 groups according to their LNR, LNR0: 0, LNR1: 0-0. Read More

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December 2018

[Gastric polyps: experience in Daniel Alcides Carrion Hospital 2014-2016].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):248-252

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Servicio de Gastroenterología, Hospital Daniel Alcidez Carrión. Callao, Perú.

Objective: The purpose of this study was to determine the prevalence of the different types of gastric polyps in the Daniel Alcides Carrión Hospital between the years of 2014 and 2016, and also define the endoscopic and histopathological characteristics of the lesions.

Materials And Methods: 7559 endoscopic reports were reviewed, in which 148 gastric polyps were found. The patients age and sex as well as the localization, number, size and macroscopic and microscopic aspects of the polyps were recorded. Read More

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December 2018

Aurora kinase B inhibitor barasertib (AZD1152) inhibits glucose metabolism in gastric cancer cells.

Anticancer Drugs 2019 Jan;30(1):19-26

Cancer Institute.

Barasertib is a highly selective Aurora kinase B (AURKB) inhibitor and has been widely applied in a variety of cancer cells to investigate the regulatory function of AURKB. However, the effect of barasertib on glucose metabolism in gastric cancer (GC) remains illustrated. Here, barasertib was identified to effectively reduce glucose uptake and lactate production in GC cells in a dose-dependent and time-dependent manner. Read More

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January 2019
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Surgical treatment of gastric cancer: a 10-year experience in a high-volume university hospital.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e543s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Surgery remains the cornerstone treatment modality for gastric cancer, the fifth most common type of tumor in Brazil. The aim of this study was to analyze the surgical treatment outcomes of patients with gastric cancer who were referred to a high-volume university hospital.

Methods: We reviewed all consecutive patients who underwent any surgical procedure due to gastric cancer from a prospectively collected database. Read More

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December 2018

Micronutrient deficiencies following bariatric surgery: a comparative analysis between sleeve gastrectomy and Roux-en-Y gastric bypass.

Rev Col Bras Cir 2018 Dec 10;45(6):e2016. Epub 2018 Dec 10.

Universidade Federal de Pernambuco, Departamento de Cirurgia, Recife, PE, Brasil.

Objective: to compare the prevalence of micronutrient deficiencies in patients submitted to sleeve gastrectomy (SG) and Roux- en-Y gastric bypass (RYGB).

Methods: this is a comparative study of 576 patients submitted to bariatric surgery, 338 to SG and 238 to RYGB, and evaluated for hemoglobin, iron, ferritin, zinc and vitamin B12 serum levels. We performed these dosages in the preoperative period and at three, six, 12 and 24 months after surgery, for analysis and comparison of micronutrient deficiencies among the techniques. Read More

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December 2018

Analysis of the lipid profile of patients submitted to sleeve gastrectomy and Roux-en-Y gastric bypass.

Rev Col Bras Cir 2018 Dec 10;45(6):e1967. Epub 2018 Dec 10.

Universidade Federal de Pernambuco, Programa de Pós-Graduação em Cirurgia, Recife, PE, Brasil.

Objective: to compare the improvements in lipid profile in patients undergoing sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB).

Methods: in a mixed cohort study, we evaluated 334 patients undergoing SG and 178 patients undergoing RYGB at the University Hospital of the Federal University of Pernambuco and at the Real Hospital Português de Beneficência, Recife, PE, Brazil. We measured serum levels of total cholesterol, LDL, HDL and triglycerides preoperatively and at three, six, 12 and 24 months follow-up. Read More

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December 2018

HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ALLEVIATES HELICOBACTER PYLORI-INDUCED GASTRO-INTESTINAL INFECTION AND GASTRIC INFLAMMATION IN C57BL/6 MICE: AN IMMUNO-HISTOLOGIC STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):279-282

Alborz University of Medical Sciences, Department of Microbiology, Karaj, Iran.

Background: Helicobacter pylori (H. pylori) has been introduced by since 1983 by Marshal and Warren to play the main role in the pathophysiology of gastritis and gastric ulcers. Almost half of the world population1 is infected by H. Read More

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THE CHANGING TREND OF MORTALITY CAUSED BY GASTROINTESTINAL CANCERS IN IRAN DURING THE YEARS 2006-2010.

Arq Gastroenterol 2018 Jul-Sep;55(3):237-241

Shiraz University of Medical Sciences, Department of Bacteriology and Virology, Shiraz, Iran.

Background: Cancers are one of the most important causes of death in the world. According to their high incidence and mortality, gastrointestinal cancers have particular importance among other cancers.

Objective: Therefore, this study was conducted to investigate the mortality change trends of gastrointestinal cancers in Iran. Read More

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February 2018

USEFULNESS OF GASTRIC SUBMUCOSAL DISSECTION DEPTH TO EVALUATE SKILL ACQUIREMENT IN SHORT TERM TRAINING COURSES IN ESD: AN EXPERIMENTAL STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):221-229

Universidade de São Paulo, Faculdade de Medicina, Departamento de Endoscopia Gastrointestinal, SP, Brasil.

Background: Endoscopic submucosal dissection (ESD) is a complex endoscopic procedure, with high rates of adverse events and technical difficulties. To overcome that problem, many training centers published the importance of animal models for skill acquirement in ESD. However, no study has used the submucosal dissection depth (DSUB) as a parameter to evaluate the learning curve in ESD, which might be a relevant factor since an optimal resection plane is important to achieve a curative resection and avoid intraoperative complications. Read More

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February 2018

COMPARISON BETWEEN THE ENDOSCOPIC FINDINGS AND THE HISTOLOGICAL DIAGNOSIS OF ANTRAL GASTRITES.

Arq Gastroenterol 2018 Jul-Sep;55(3):212-215

Universidade Federal de Juiz de Fora (UFJF), Programa de Pós-graduação em Saúde, MG, Brasil.

Background: Gastritis is a very common disorder that is widely distributed worldwide, representing one of the most prevalent pathological entities in Gastroenterology and Digestive Endoscopy.

Objective: This study aims to analyze the correlation between the endoscopic findings and the histological diagnosis of antral gastritis.

Methods: In this study, 92 reports of upper digestive endoscopy were performed between November 2014 and January 2015, including biopsy of the antral gastric mucosa, comparing the endoscopic and histological findings, which were classified according to the Sidney System. Read More

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January 2018
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VITAMIN D DEFICIENCY AND PARATOHOMMONIUM INCREASE IN LATE POSTOPERATIVE GASTRIC BYPASS IN ROUX-EN-Y.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1407. Epub 2018 Dec 6.

Lane Clinic, Campinas, SP, Brazil.

Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency.

Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up.

Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. Read More

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December 2018

IMPACT OF BARIATRIC SURGERY ON THE INFLAMMATORY STATE BASED ON CPR VALUE.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1402. Epub 2018 Dec 6.

Hospital of the Municipal Public Server, Technical Section of Digestive System Surgery, São Paulo, SP, Brazil.

Background: PCR (C-reactive protein), produced in the liver after stimuli of inflammatory mediators, is determined as a marker of inflammatory activity (adipocytokines) and is present within adipocyte cells; besides being an inflammatory product, many studies have shown to be a predictor of complications.

Aim: To determine if the inflammatory state of the obese patient decreases after bariatric surgery, based on pre and post-operative PCR.

Methods: A prospective, observational study in patients undergoing Roux-en-Y gastric by-pass surgery followed up for three months after surgery, with serum preoperative CRP in 30, 60 and 90 days after surgery. Read More

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December 2018

THE ROLE OF SERUM CK-18, MMP-9 AND TIPM-1 LEVELS IN PREDICTING R0 RESECTION IN PATIENTS WITH GASTRIC CANCER.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1401. Epub 2018 Dec 6.

Haseki Training and Research Hospital, Department of General Surgery.

Background: Gastric cancer is the 3rd most common cause of death in men and the 5th common in women worldwide. Today, surgery is the only curative therapy. Currently available advanced imaging modalities can predict R0 resection in most patients, but it can only be detected with certainty in the perioperative period. Read More

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December 2018

POSTOPERATIVE CHANGES IN INTESTINAL MICROBIOTA AND USE OF PROBIOTICS IN ROUX-EN-Y GASTRIC BYPASS AND SLEEVE VERTICAL GASTRECTOMY: AN INTEGRATIVE REVIEW.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1400. Epub 2018 Dec 6.

Postgraduate Program in Food and Nutrition.

Introduction: Studies suggest that weight loss induced by bariatric surgery and the remission of some comorbidities may be related to changes in the microbiota profile of individuals undergoing this procedure. In addition, there is evidence that manipulation of the intestinal microbiota may prove to be a therapeutic approach against obesity and metabolic diseases.

Objective: To verify the changes that occur in the intestinal microbiota of patients undergoing bariatric surgery, and the impact of the usage of probiotics in this population. Read More

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December 2018

Gastric metastasis of recurrent hepatocellular carcinoma: A case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1230-S1232

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Hepatocellular carcinoma (HCC) with gastric metastasis is seldom reported. It is extremely easy to misdiagnose for primary gastric cancer with liver metastasis, especially gastric hepatoid adenocarcinoma. Here, we report a case of recurrent HCC with gastric metastasis in a 22-year-old man. Read More

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December 2018
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Endostar continuous intravenous infusion combined with S-1 and oxaliplatin chemotherapy could be effective in treating liver metastasis from gastric cancer.

J Cancer Res Ther 2018 Dec;14(Supplement):S1148-S1151

Department of Oncology. Dongying People's Hospital, Dongying, Shandong, China.

Objective: Endostar is a new vascular epithelial inhibitor, which is reported to be effective in treating liver metastasis from gastric cancer. However, the optimal therapeutic regimen of Endostar remains unclear. Thus, our study aimed to examine the efficacy and safety of Endostar continuous intravenous infusion combined with S-1 and oxaliplatin (SOX) chemotherapy in treating such patients. Read More

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December 2018

Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS).

Methods Mol Biol 2019 ;1901:113-131

Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

The Luciferase Immuno Precipitation System (LIPS) enables the detection of specific serum antibodies by immunoprecipitation of recombinant antigens tagged with a luciferase reporter. Here we describe LIPS assays for the quantification of autoantibodies to the H+, K+-ATPase A (ATP4A) and B (ATP4B) subunits, two serological markers of autoimmune atrophic gastritis and pernicious anemia. In particular, we will describe the expression of luciferase-tagged recombinant ATP4A and ATP4B, their immunoprecipitation with test sera, the recovery and washing of immune-complexes with a protein-A coated resin, and the quantification of autoantibodies by addition of a luciferase substrate and the measurement of the light output from captured luciferase-tagged antigens. Read More

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January 2019

Management of Acute Gallstone Cholangitis after Roux-en-Y Gastric Bypass with Laparoscopic Transgastric Endoscopic Retrograde Cholangiopancreatography.

Obes Surg 2018 Dec 11. Epub 2018 Dec 11.

Service de Chirurgie Générale et Endocrinienne, CHU Lille, Hôpital Huriez, Rue Michel Polonowski, 59000, Lille, France.

Background: The incidence of biliary lithiasis is increased after bariatric surgery due to rapid weight loss [1]. Trans-oral endoscopic management in cases of common bile duct gallstone complication is not possible in patients with Roux-en-Y gastric bypass (RYGB) due to the modified anatomy. Access to the biliary tree after RYGB with a classical direct surgical approach of common bile duct and choledocoscopy can be used, but may be complicated in situations of acute cholangitis because of the fragility of common duct, or in cases of previous cholecystectomy. Read More

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December 2018

ASO Author Reflections: Use of the Survival Recurrent Network for Prediction of Overall Survival in Patients with Gastric Cancer.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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December 2018

Surgical risk and benefits of laparoscopic surgery for elderly patients with gastric cancer: a multicenter prospective cohort study.

Gastric Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Ariake Hospital of Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo, Japan.

Background: Laparoscopic gastrectomy (LG) might have greater clinical benefits for elderly patients as less invasive surgery; however, there is still little evidence to support its benefit. We evaluated the surgical outcomes of elderly patients in a nationwide prospective cohort study.

Methods: One hundred and sixty-nine participating institutions were identified by stratified random sampling, and were adjusted for hospital volume, type and location. Read More

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December 2018
1 Read

Objective image analysis of non-magnifying image-enhanced endoscopy for diagnosis of small depressed early gastric cancers.

Endosc Int Open 2018 Dec 10;6(12):E1445-E1453. Epub 2018 Dec 10.

Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

 Gastric cancers (GC) after eradication are difficult to diagnose even by magnifying narrow-band imaging (NBI) or blue laser imaging (BLI) endoscopy. Little is known with regard to non-magnifying (NM)-NBI/BLI for early GC so we examined the efficacy of NM-NBI/BLI for early GC diagnosis.  We retrospectively analyzed the images of 29 small (≤ 1 cm) intramucosal GC that had been treated with endoscopic submucosal dissection and 137 benign depressed lesions (BDLs). Read More

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December 2018
2 Reads

Novel three-dimensional imaging system may facilitate gastric endoscopic submucosal dissection procedure: an ex vivo animal study.

Endosc Int Open 2018 Dec 10;6(12):E1431-E1435. Epub 2018 Dec 10.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

 Endoscopic submucosal dissection (ESD) requires advanced skills to perform safely without complications. The current study evaluated the usefulness of a novel three-dimensional (3D) imaging system in ESD using porcine stomachs.  Four endoscopists (two trainees and two experts) performed eight ESD procedures using both 3D and 2D images. Read More

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December 2018

Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis.

Biomed Res Int 2018 14;2018:4039173. Epub 2018 Nov 14.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Read More

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November 2018

The prevalence of (Diptera: Oestridae) in donkeys () in Egypt with special reference to larvicidal effects of neem seed oil extract () on third stage larvae.

Open Vet J 2018 15;8(4):423-431. Epub 2018 Nov 15.

Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box 12211, Egypt.

larvae are of veterinary and medical importance caused specific equine intestinal myiasis. (Botfly larvae) had a wide geographical distribution. The present study explores the prevalence rate of 3 stage larvae in Egypt from January- December 2017; besides, in vitro trials to control of this larvae and evaluation of this trial using Scanning Electron Microscope (SEM) and histopathology of treated larvae. Read More

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November 2018

A Rare Case of an Advanced Gastric Adenocarcinoma in a Teenage Syrian Boy.

Case Rep Oncol Med 2018 14;2018:9140593. Epub 2018 Nov 14.

Faculty of Medicine, University of Aleppo, Aleppo, Syria.

In this report, we describe a case of a gastric cancer in young age group with delayed diagnosis and poor prognosis. We report a rare case of a 16-year-old teenager with an advanced moderately differentiated gastric adenocarcinoma without any relevant history. He presented mainly with dysphagia, postprandial vomiting, and eventually hematemesis. Read More

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November 2018

Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats.

Gastroenterol Res Pract 2018 13;2018:6309157. Epub 2018 Nov 13.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background/aims: The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders, but the mechanisms of GES require clarification.

Methods: Male rats were randomly divided into the control group, diabetic rat group (DM), diabetic rats with sham GES group (DM + SGES), and diabetic rats with different frequency GES group (DM + GES) (GES1: 5. Read More

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November 2018

Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway.

Front Pharmacol 2018 27;9:1392. Epub 2018 Nov 27.

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China.

Although trastuzumab has shown considerable activity in the treatment of HER2-positive breast and gastric cancers, a significant proportion of patients do not respond to trastuzumab. Recent studies revealed that osthole, an active coumarin isolated from (L.) Cusson possesses potent anti-tumor activity. Read More

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November 2018

Current and Emerging Therapeutic Options for Gastroparesis.

Gastroenterol Hepatol (N Y) 2018 Nov;14(11):639-645

Dr Myint, Dr Rieders, and Dr Tashkandi are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC; director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; and is affiliated with Medical Faculty Associates. Dr Koh and Dr Stephen are in private practice in Silver Spring, Maryland. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine and is in private practice in Silver Spring, Maryland.

Gastroparesis is a complex, debilitating dysmotility disorder with challenging symptom management. A diagnosis of gastroparesis is based on objectively delayed gastric emptying in the absence of mechanical obstruction. Given the limited efficacy of treatment options and serious side effects, significant research continues for therapeutic options for gastroparesis. Read More

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November 2018

Upregulation of KIF20A correlates with poor prognosis in gastric cancer.

Cancer Manag Res 2018 23;10:6205-6216. Epub 2018 Nov 23.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China,

Background: KIF20A is well known as one of the key proteins in mitosis. Recently, a number of studies illustrated that might function as an oncogene in some carcinomas. However, its expression levels and clinical value remained unclear in gastric cancer (GC). Read More

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November 2018

First-line chemotherapy regimens for locally advanced and metastatic pancreatic adenocarcinoma: a Bayesian analysis.

Cancer Manag Res 2018 20;10:5965-5978. Epub 2018 Nov 20.

Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,

Background: Systemic chemotherapy is the standard treatment for locally advanced and metastatic pancreatic cancer, but there is no consensus on the optimum regimen. We aimed to compare and rank the locally advanced and metastatic pancreatic adenocarcinoma chemotherapy regimens evaluated in randomized controlled trials (RCTs) in the past 15 years.

Materials And Methods: PubMed, Embase, Cochrane Collaboration database, and ClinicalTrials. Read More

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November 2018

Modified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake.

Onco Targets Ther 2018 23;11:8301-8307. Epub 2018 Nov 23.

Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,

Background: Oral fluoropyrimidine plus platinum is a standard first-line treatment for advanced gastric cancer (AGC). However, this treatment is problematic for AGC patients with massive ascites or inadequate oral intake. This study aimed at evaluating the efficacy and safety of modified oxaliplatin (L-OHP) with l-leucovorin (l-LV) and bolus/continuous infusion of 5-fluorouracil (5-FU) (mFOLFOX6) regimen for patients with massive ascites or inadequate oral intake. Read More

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November 2018

Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis.

Onco Targets Ther 2018 21;11:8251-8263. Epub 2018 Nov 21.

School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China,

Background: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. Read More

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November 2018

Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: an evidence-based review of therapies.

Onco Targets Ther 2018 21;11:8239-8250. Epub 2018 Nov 21.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan,

Standard treatment options for patients with advanced gastric cancer (GC) offer limited efficacy and are associated with some toxicity, which necessitates the development of more effective therapies for improving the treatment outcomes for this disease. Immunotherapy involving immune checkpoint inhibitors (ICIs) which inhibit the programmed death 1 (PD-1)/programmed death ligand 1 interaction has emerged as a new treatment option. Nivolumab, a human IgG4 monoclonal antibody inhibitor of PD-1, has demonstrated promising clinical activity and induced durable responses in patients with advanced GC. Read More

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November 2018
1 Read

Multiple Gastrointestinal Cancers in a Single Patient-a Rare Clinical Entity.

Indian J Surg Oncol 2018 Dec 16;9(4):633-635. Epub 2018 May 16.

Department of Surgical Oncology, BLK Hospital, Rajinder Place, New Delhi, 110008 India.

Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Read More

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December 2018
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Granular Cell Tumour in Stomach: a Case Report.

Indian J Surg Oncol 2018 Dec 21;9(4):598-600. Epub 2018 Jul 21.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai-12, India.

Granular cell tumours are uncommon, usually benign soft tissue tumours. They are thought to be neural, arising from Schwann cells and can occur at various sites. Their occurrence in gastrointestinal tract is rare, the commonest site being oesophagus followed by large intestine. Read More

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December 2018
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Esophageal Metallic-Stent Migration: a Rare Cause of Anal Pain in a Patient with Gastric Cancer.

Indian J Surg Oncol 2018 Dec 16;9(4):576-577. Epub 2018 May 16.

2Department of Surgery, Hospital General Tacuba, ISSSTE, Mexico City, Mexico.

Stents are a great development for esophageal fistula treatment; however, stent migration is a frequent complication. A stent migration that caused anal pain is presented. A 79-year-old man with poorly differentiated gastric carcinoma was submitted to a total gastrectomy with a Roux-en-Y esophagojejunostomy. Read More

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December 2018

Clinical Utility of Staging Laparoscopy for Advanced Obstructing Rectal Adenocarcinoma: Emerging Tool.

Indian J Surg Oncol 2018 Dec 2;9(4):488-494. Epub 2018 Aug 2.

1Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Dr Ernest Borges Marg, Parel, Mumbai, Maharashtra 400012 India.

The multimodal treatment for advanced rectal adenocarcinoma mandates accurate preoperative staging with contrast-enhanced computed tomography (CECT) of the thorax, abdomen, and pelvis, and magnetic resonance imaging (MRI) of the pelvis. Unlike gastric cancer, the role of staging laparoscopy (SL) in advanced colorectal cancer has not been evaluated. This study aims to evaluate the clinical value of SL in treatment decision-making for advanced rectal cancer (RC) with near or complete obstructing tumors. Read More

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December 2018

Etiologic and Clinicopathological Correlates of Gastric Carcinoma in the Egyptian Delta.

Indian J Surg Oncol 2018 Dec 23;9(4):472-476. Epub 2018 May 23.

Clinical Oncology Unit, Mit Ghamr Oncology Center, Dakahlia Governorate, Cairo, Egypt.

We aimed at evaluation of the clinicoepidemiologic data of patients with gastric carcinoma in the Egyptian Delta as regards the etiologic factors, behavior, presenting symptoms, and tumor location, grade, and stage with highlighting of the treatment modalities, survival, and prognostic factors. Three hundred cases with gastric carcinoma were enrolled, diagnosed, and treated in a tertiary oncology center in the Egyptian Delta. Data were collected as regards the etiology, presenting symptoms, family history, comorbid conditions, treatment modalities, responses, recurrences, and survival outcomes. Read More

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December 2018

Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement.

Nat Commun 2018 12 11;9(1):5278. Epub 2018 Dec 11.

Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan.

Regulation of intracellular pH is critically important for many cellular functions. The quantification of proton extrusion in different types of cells and physiological conditions is pivotal to fully elucidate the mechanisms of pH homeostasis. Here we show the use of gold nanoparticles (AuNP) to create a high spatial resolution sensor for measuring extracellular pH in proximity of the cell membrane. Read More

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December 2018

Pancreaticoduodenectomy and placement of operative enteral access: Better or worse?

Am J Surg 2018 Nov 28. Epub 2018 Nov 28.

Division of Surgical Oncology, Department of Surgery, Henry Ford Hospital, Detroit, MI, USA. Electronic address:

Background: It is unclear whether placement of operative enteral access (OEA) during pancreaticoduodenectomy (PD) correlates with decreased morbidity.

Methods: A retrospective chart review of patients undergoing PD with and without OEA placement between January 2016 and May 2018 was undertaken. Outcomes included length of stay (LOS), 30- and 90-day readmission, initiation of total parenteral nutrition (TPN), postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), and surgical site infection (SSI). Read More

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November 2018

HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer.

Clin Epigenetics 2018 Dec 11;10(1):153. Epub 2018 Dec 11.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: B7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targeted cancer therapy. Interferon gamma (IFN-γ) is thought to be the main driving force behind B7-H1 expression, and epigenetic factors including histone acetylation are recently linked to the process. Read More

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December 2018

Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery.

Biomacromolecules 2018 Dec 11. Epub 2018 Dec 11.

Oral drug delivery is a more favored mode of administration because of its ease of administration, high patient compliance, and low healthcare costs. However, no oral protein formulations are commercially available currently due to the hostile gastrointestinal (GI) barriers resulting in insignificant oral bioavailability of macromolecular drugs. Herein, we used insulin as a model protein drug, insulin-loaded N-(2-hydroxy)-propyl-3-trimethylammonium chloride modified chitosan (HTCC)/sodium tripolyphosphate (TPP) nanocomplex (NC) as a nanocore was further encapsulated into enteric Eudragit L100-55 material through two-step flash nanocomplexation (FNC) process in a reliable and scalable manner, forming our NC-in-Eudragit composite particles (NE). Read More

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December 2018
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miR-494 Sensitizes Gastric Cancer Cells to TRAIL Treatment Through Downregulation of Survivin.

Cell Physiol Biochem 2018 7;51(5):2212-2223. Epub 2018 Dec 7.

Department of Internal Medicine, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou,

Background/aims: TNF-related apoptosis-inducing ligand (TRAIL) is a novel and low-toxic anti-tumor drug used for various cancers. However, cancer cells usually develop mechanisms to acquire the resistance against TRAIL. Among these changes, dysregulation of microRNAs (miRNAs) usually occurs in cancer cells and is responsible for induction of drug resistance. Read More

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December 2018
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Melatonin inhibits the migration of human gastric carcinoma cells at least in part by remodeling tight junction.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, People's Republic of China.

The recurrence and metastasis is one of the major reasons for malignant tumor treatment failure. Melatonin, a naturally occuring hormone, could reduce the recurrence and metastasis of various tumors. However, the underlying molecular mechanisms of melatonin on tumor metastasis inhibition have not been fully elucidated. Read More

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December 2018