2,756 results match your criteria Gastric Gastrointestinal Stromal Tumors


Digital image analysis-based scoring system for endoscopic ultrasonography is useful in predicting gastrointestinal stromal tumors.

Gastric Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Pusan National University School of Medicine, Busan, South Korea.

Background: When gastric mesenchymal tumors (GMTs) measuring 2-5 cm in size are found, whether to undergo further treatment or not is controversial. Endoscopic ultrasonography (EUS) is useful for the evaluation of malignant potential of GMTs, but has limitations, such as subjective interpretation of EUS images. Therefore, we aimed to develop a scoring system based on the digital image analysis of EUS images to predict gastrointestinal stromal tumors (GISTs). Read More

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http://dx.doi.org/10.1007/s10120-019-00928-wDOI Listing
February 2019

[Two Cases of Resectable Intra-Abdominal Desmoid Tumor after Laparoscopic Gastrectomy for Gastric Cancer].

Gan To Kagaku Ryoho 2019 Jan;46(1):118-120

Dept. of Gastroenterological Surgery, Sendai Kousei Hospital.

Case 1: A 52-year-old man underwent laparoscopic total gastrectomy for gastric cancer. After 2 years, a follow-up computed tomography(CT)scan showed a large, solid 10 cm-sized mass in his left upper abdomen. Under the diagnosis of a suspected mesenchymal tumor, a tumor resection with a partial resection of the upper jejunum and transverse colon was performed. Read More

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January 2019
1 Read

PRE-OPERATIVE GASTRIC GIST DOWNSIZING: THE IMPORTANCE OF NEOADJUVANT THERAPY.

Arq Bras Cir Dig 2019 Feb 7;32(1):e1427. Epub 2019 Feb 7.

Hospital das Clínicas, Universidade Federal de Minas Gerais, Alfa Institute of Gastroenterology, Belo Horizonte, MG, Brazil.

Introduction: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, higher postoperative morbidity and mortality.

Objective: To perform a review the literature on the topic, with emphasis on the neoadjuvant therapy. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368167PMC
February 2019
1 Read

Gastrointestinal stromal tumor leading to acute abdomen and hypovolemic shock in a trauma patient.

Ulus Travma Acil Cerrahi Derg 2019 Jan;25(1):83-85

Department of General Surgery, İstanbul Medicine Hospital, İstanbul-Turkey.

Gastrointestinal stromal tumors (GISTs) are among the rare tumors of gastrointestinal (GI) tract. GISTs occur respectively in the stomach, small intestines, colon and rectum, omentum and mesentery, esophagus, retroperitoneal space, and abdominal cavity. However, they may occur anywhere along the GI tract. Read More

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http://www.tjtes.org/eng/jvi.aspx?pdir=travma&plng=eng&a
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http://dx.doi.org/10.5505/tjtes.2018.35005DOI Listing
January 2019
4 Reads

Submucosal 1-tunnel endoscopic resection for treating upper gastrointestinal multiple submucosal tumor originating from the muscularis propria layer: A report of 12 cases.

Medicine (Baltimore) 2019 Feb;98(6):e14484

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

To explore the feasibility and efficacy of submucosal 1-tunnel endoscopic resection (1-tunnel STER) for the treatment of multiple upper gastrointestinal submucosal tumors (GI-SMTs) originating from the muscularis propria (MP) layer.A total of 12 patients with multiple upper GI-SMTs (no less than 2 SMTs) who underwent 1-tunnel STER from April 2013 to October 2017 were included. Clinical data on general characteristics, operation-related parameters, adverse events, and follow-up results were recorded and analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014484DOI Listing
February 2019

A mucosal incision assisted biopsy vs. endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized crossover study.

Dig Endosc 2019 Feb 5. Epub 2019 Feb 5.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objectives: This study aimed to compare the diagnostic yield of mucosal incision-assisted biopsy (MIAB) and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with a rapid on-site evaluation (ROSE) for gastric subepithelial lesions (SELs) suspected of being gastrointestinal stromal tumors (GISTs) with an intraluminal growth pattern.

Methods: This was a prospective randomized crossover, multicenter study. The primary outcome was the diagnostic yield of EUS-FNA and MIAB. Read More

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http://dx.doi.org/10.1111/den.13367DOI Listing
February 2019
1 Read

Gastrointestinal stromal tumors. A clinicopathological study.

Saudi Med J 2019 Feb;40(2):126-130

Department of Surgery, College of Medicine, King Fahad Hospital of the University, University of Imam Abdurahman Bin Faisal, Al Khobar, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the clinical presentations and immunohistochemical (IHC) properties of gastrointestinal stromal tumors (GISTs) and to compare them to internationally published data.

Methods: Thirty-six patients diagnosed with GISTs between January 1997 and December 2015 were retrospectively studied in 2 tertiary hospitals. Immunohistochemical staining was carried out prospectively when it has not been completed fully at the beginning. Read More

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http://dx.doi.org/10.15537/smj.2019.2.23913DOI Listing
February 2019
1 Read
0.554 Impact Factor

Impact of in vitro driven expression signatures of CD133 stem cell marker and tumor stroma on clinical outcomes in gastric cancers.

BMC Cancer 2019 Feb 4;19(1):119. Epub 2019 Feb 4.

Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea.

Background: The CD133 transmembrane protein is a well-recognized stem cell marker that has been used to isolate putative cancer stem cell populations from gastric cancers (GCs). However, the molecular features or biomarkers underlying CD133 are largely unknown in GCs.

Methods: We performed gene expression profiling of CD133+ and CD133- cells sorted by flow cytometry from three GC cell lines to identify the CD133 expression signatures of GC. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5332-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360664PMC
February 2019
2 Reads

Surgical treatment of gastrointestinal stromal tumours combined with imatinib treatment: a retrospective cohort analysis.

Transl Gastroenterol Hepatol 2018 27;3:108. Epub 2018 Dec 27.

Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany.

Background: Targeted therapies changed the treatment concepts of gastrointestinal stromal tumours significantly. As only possibility to cure surgical resection is the cornerstone of therapy. Thus it is necessary to find out which patients will benefit most regarding modality (neo- or adjuvant) and duration of chemotherapy. Read More

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http://dx.doi.org/10.21037/tgh.2018.12.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327167PMC
December 2018
1 Read

Identification of imatinib-resistant long non-coding RNAs in gastrointestinal stromal tumors.

Oncol Lett 2019 Feb 11;17(2):2283-2295. Epub 2018 Dec 11.

Department of Radiotherapy and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Long non-coding RNAs (lncRNAs) are an abundant RNA species that belong to the competing endogenous RNA network, which serves a critical role in the development, diagnosis and progression of diseases. Using chip technology, the current study analyzed the expression of lncRNAs in paired normal gastric tissues, primary gastrointestinal stromal tumor (GIST) tissues and GIST tissues resistant to imatinib mesylate. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to predict potential tumorigenesis and drug resistance mechanisms. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9821
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http://dx.doi.org/10.3892/ol.2018.9821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341907PMC
February 2019
3 Reads

Pediatric plexiform fibromyxoma: A PRISMA-compliant systematic literature review.

Medicine (Baltimore) 2019 Jan;98(3):e14186

Department of Pathology, National Hospital Organization Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Oita, Japan.

Background: Plexiform fibromyxoma (PF) is a rare gastric mesenchymal tumor, with approximately 80 cases reported to date. Gastrointestinal stromal tumor, the most common primary mesenchymal tumor of the stomach, shows different biological and clinical characteristics between adult and pediatric patients.

Objectives: This systematic literature review was conducted to elucidate the pathological and clinical features of pediatric PF compared to adult PF. Read More

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http://dx.doi.org/10.1097/MD.0000000000014186DOI Listing
January 2019
1 Read

What is the appropriate duration of adjuvant imatinib mesylate treatment for primary gastrointestinal stromal tumors classified according to the strict definition of tumor rupture?

Medicine (Baltimore) 2019 Jan;98(3):e14177

Department of Gastric Surgery, Fujian Medical University Union Hospital.

In gastrointestinal stromal tumors (GISTs), rupture is a high-risk feature; however, "tumor rupture" is inconsistently defined, and its prognostic value remains controversial.Six hundred ninety-one patients undergoing surgery for primary nonmetastatic GISTs from 2003 to 2015 at our institution were enrolled. The strict definitions of "tumor rupture" according to the Kinki GIST Study Group (KGSG) were used. Read More

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http://dx.doi.org/10.1097/MD.0000000000014177DOI Listing
January 2019
1 Read

Tenascin-C expression is significantly associated with the progression and prognosis in gastric GISTs.

Medicine (Baltimore) 2019 Jan;98(2):e14045

Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Tenascin-C (TNC), an extracellular matrix glycoprotein, has been implicated in progression of various types of cancer. However, few reports exist on TNC expression in gastrointestinal stromal tumors (GISTs). We here attempted to investigate the expression pattern and prognostic significance of TNC in gastric GISTs. Read More

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http://dx.doi.org/10.1097/MD.0000000000014045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336641PMC
January 2019
2 Reads

Collision Tumor of Adenocarcinoma and Gastrointestinal Stromal Tumor in the Small Bowel.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):715-721. Epub 2018 Nov 28.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University Hospital, Tokyo, Japan.

We report a very rare case of collision tumor composed of primary adenocarcinoma of the jejunum and gastrointestinal stromal tumor (GIST). The patient was a 63-year-old man who visited our hospital for epigastralgia and vomiting. Abdominal computed tomography revealed a mass in the upper jejunum, with gastric and duodenal dilatation. Read More

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https://www.karger.com/Article/FullText/495246
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http://dx.doi.org/10.1159/000495246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323411PMC
November 2018
11 Reads

A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors.

Invest New Drugs 2019 Jan 9. Epub 2019 Jan 9.

Eisai Co. Ltd., Tokyo, Japan.

Background We conducted a first-in-Japanese, phase I study of ontuxizumab, a humanized, anti-endosialin monoclonal antibody, to confirm its tolerability, safety, and pharmacokinetics, and identify exploratory efficacy. Methods This was a multicenter, multiple-dose, open-label study in Japanese patients aged ≥20 years with solid tumors, including gastric cancer (GC) or advanced hepatocellular carcinoma (HCC), who had failed standard chemotherapy. The study comprised two parts: part 1 (dose-escalation; ontuxizumab 2-12 mg/kg weekly) and part 2 (cohort-expansion; 4 or 8 mg/kg weekly, or 12 mg/kg biweekly). Read More

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http://dx.doi.org/10.1007/s10637-018-0713-7DOI Listing
January 2019
1 Read

The roles of CT and EUS in the preoperative evaluation of gastric gastrointestinal stromal tumors larger than 2 cm.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of General Surgery, Nanfang Hospital, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, Southern Medical University, No.1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.

Objective: This study aimed to investigate the endoscopic ultrasound (EUS) and computed tomography (CT) features of gastric gastrointestinal stromal tumors (GISTs) for assessing potential malignancy and prognosis.

Methods: Fifty consecutive patients with primary gastric GISTs larger than 2 cm were retrospectively enrolled in this study. The association of CT and EUS features with malignancy was analyzed using univariate and stepwise logistic regression method. Read More

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http://dx.doi.org/10.1007/s00330-018-5945-6DOI Listing
January 2019
3 Reads

Gastrointestinal stromal tumors and synchronous intra-abdominal malignancies: Review of the literature.

J BUON 2018 Nov-Dec;23(6):1573-1579

Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa, Thessaly, 41110, Greece.

Purpose: Gastrointestinal stromal tumors (GISTs) are the most frequent neoplasms of mesenchymal origin affecting the gastrointestinal tract. GISTs quite frequently co-exist with other primary tumors in up to 33% of the cases. Such occurrence has been mainly described in the literature in the form of case reports and rarely of case series which hasn't been sufficient to prove if there is any association between these two entities. Read More

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January 2019
1 Read

Unexpected Intraoperative Findings, Situations, and Complications in Bariatric Surgery.

Obes Surg 2019 Jan 4. Epub 2019 Jan 4.

The Obesity Clinic at Hospital General Tláhuac, Avenida la Turba # 655, Col. Villa Centroamericana y del Caribe, Delegación Tláhuac, Zip 13250, México City, Mexico.

Background: Bariatric surgery is considered a safe therapy to treat obesity. Postoperative complications are well known; however, there is a lack of data describing intraoperative complications and/or unexpected findings, and if there is further impact on outcomes.

Methods: Retrospective study with patients operated between 2013 and 2016 at a single institution. Read More

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http://dx.doi.org/10.1007/s11695-018-03672-9DOI Listing
January 2019
1 Read
3.747 Impact Factor

Management of Gastric Stromal Tumour - Multicenter Observational Study.

Chirurgia (Bucur) 2018 Nov-Dec;113(6):780-788

Gastrointestinal stromal tumors are some of the most common mesenchymal tumors of the gut. The aim of this study is to asses the clinical manifestation and treatment of gastric GISTs. Methodology: We performed a retrospective 5-year multicenter study conducted on a prospective collected database, which includes all the patients diagnosed with GIST in which surgery was performed. Read More

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http://dx.doi.org/10.21614/chirurgia.113.6.780DOI Listing
December 2018
1 Read

A new nomogram for recurrence-free survival prediction of gastrointestinal stromal tumors: Comparison with current risk classification methods.

Eur J Surg Oncol 2018 Dec 21. Epub 2018 Dec 21.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, Guangzhou, 510515, Guangdong Province, China. Electronic address:

Background: This study aimed to build a new risk stratification nomogram for gastrointestinal stromal tumors (GISTs) focused on a popular factor Ki-67 to enable individualized and precise predictions of the most suitable candidates for imatinib therapy.

Methods: We retrospectively collected clinicopathologic data of the patients diagnosed with GISTs from January 1998 to December 2015 at Southern Medical University Nanfang Hospital as the experiment group. And patients with GISTs at the Sun Yat-sen University Cancer Center from January 2007 to December 2012 were included as the validation group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183203
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http://dx.doi.org/10.1016/j.ejso.2018.12.014DOI Listing
December 2018
8 Reads

Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report.

BMC Infect Dis 2018 Dec 27;18(1):693. Epub 2018 Dec 27.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

Background: Highly active antiretroviral therapy has significantly changed the natural history of HIV infection, leading to a dramatic reduction of HIV-related morbidity and mortality. Late Presenters, Very Late Presenters and AIDS presenters still represent, also in Europe, including Italy, a huge challenge in terms of diagnostic and therapeutic management.

Case Presentation: A 35-year-old male with a history of fever and back pain. Read More

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http://dx.doi.org/10.1186/s12879-018-3573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307234PMC
December 2018
4 Reads

Chinese consensus on management of tyrosine kinase inhibitor-associated side effects in gastrointestinal stromal tumors.

World J Gastroenterol 2018 Dec;24(46):5189-5202

Department of Gastrointestinal Surgery, Reiji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Tyrosine kinase inhibitors (TKIs) have improved the overall survival of patients with gastrointestinal stromal tumors (GISTs), but their side effects can impact dose intensity and, consequently, the clinical benefit. To date, no guideline or consensus has been published on the TKI-associated adverse reactions. Therefore, the Chinese Society of Surgeons for Gastrointestinal Stromal Tumor of the Chinese Medical Doctor Association organized an expert panel discussion involving representatives from gastrointestinal surgery, medical oncology, cardiology, dermatology, nephrology, endocrinology, and ophthalmology to consider the systemic clinical symptoms, molecular and cellular mechanisms, and treatment recommendations of GISTs. Read More

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http://dx.doi.org/10.3748/wjg.v24.i46.5189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295840PMC
December 2018
10 Reads

Endoscopic ultrasound-guided needle-based confocal laser endomicroscopy for diagnosis of gastric subepithelial tumors: a pilot study.

Endoscopy 2018 Dec 20. Epub 2018 Dec 20.

Department of Gastroenterology, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University, Jinan, China.

Background:  The diagnostic yield of current techniques for gastric subepithelial tumors (SETs) is suboptimal. This prospective study aimed to develop diagnostic criteria for needle-based confocal laser endomicroscopy (nCLE) of gastric SETs, and to evaluate the diagnostic efficacy, feasibility, and safety of endoscopic ultrasound-guided nCLE (EUS-nCLE).

Methods:  Eligible patients were prospectively recruited to undergo EUS-nCLE. Read More

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http://dx.doi.org/10.1055/a-0790-8436DOI Listing
December 2018
3 Reads

Endoscopic full-thickness resection for gastric gastrointestinal stromal tumor originating from the muscularis propria.

Rev Assoc Med Bras (1992) 2018 Nov;64(11):1002-1006

Department of Gastroenterology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, China.

Objective: This study retrospectively reviewed 46 cases of gastric gastrointestinal stromal tumors treated by endoluminal endoscopic full-thickness resection (EFR) microsurgery in our gastrointestinal endoscopy center. We aimed to evaluate the EFR for the treatment of gastric gastrointestinal stromal tumors originating from the muscularis propria.

Methods: A total of 46 patients with gastric gastrointestinal stromal tumors originated from the muscularis propria layer from January 2012 to June 2015 were treated with EFR. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.64.11.1002DOI Listing
November 2018
12 Reads

Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress.

Oncol Rep 2019 Mar 19;41(3):1616-1626. Epub 2018 Dec 19.

Division of Oncology, Department of Internal Medicine, Korea University College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea.

Imatinib is a powerful tyrosine kinase inhibitor that specifically targets BCR‑ABL, c‑KIT, and PDGFR kinases, and is used in the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors, and other types of cancers. However, the possible anticancer effects of imatinib in gastric cancer have not yet been explored. The present study evaluated the in vitro effects of imatinib on gastric cancer cells and determined the molecular mechanism underlying these effects. Read More

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http://dx.doi.org/10.3892/or.2018.6945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365688PMC
March 2019
1 Read

Plexiform fibromyxoma of the small bowel: A case report.

World J Clin Cases 2018 Dec;6(15):1067-1072

Department of Endoscopy, the Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China.

Background: Plexiform fibromyxoma is a rare, special type of mesenchymal tumor. The most common presenting symptoms are anemia, hematemesis, and hematochezia, without sex or age predilection. The reported cases have mainly occurred in the gastric antrum and pylorus region, with some cases in the duodenum. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i15/1067.htm
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http://dx.doi.org/10.12998/wjcc.v6.i15.1067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288503PMC
December 2018
12 Reads

Primary lung squamous cell carcinoma with gastric metastasis: A case report.

Thorac Cancer 2019 Feb 18;10(2):373-377. Epub 2018 Dec 18.

Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Approximately 50% of patients with primary lung cancer have distant metastasis at the time of their first visit, but gastric metastasis is a rare occurrence. Herein, we report a case of progressive dysphagia as the first symptom and the final diagnosis of primary lung squamous cell carcinoma metastasis. A 61-year-old man was diagnosed with a solitary left lower lobe tumor and a solitary carcinoma of gastric cardia suspected to be metastatic or malignant stromal tumors. Read More

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http://dx.doi.org/10.1111/1759-7714.12940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360227PMC
February 2019
1 Read

Primary gastric inflammatory myofibroblastic tumor: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13423

Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Rationale: Primary gastric inflammatory myofibroblastic tumor is extremely rare. Only a few cases were reported in the domestic and foreign medical literature with corresponding imaging findings of this disease even more rarely reported.

Patient Concerns: We present one case of a 52-year-old female patient with upper abdominal pain, acid reflux, and belching for 2 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320093PMC
December 2018
1 Read
5.723 Impact Factor

Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report.

Surg Case Rep 2018 Dec 13;4(1):144. Epub 2018 Dec 13.

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Gastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.

Case Presentation: An 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Read More

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http://dx.doi.org/10.1186/s40792-018-0553-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292835PMC
December 2018
1 Read

Pathologic Complete Response in a Large Gastric GIST: Using Molecular Markers to Achieve Maximal Response to Neoadjuvant Imatinib.

J Natl Compr Canc Netw 2018 Dec;16(12):1424-1428

Division of Surgical Oncology, Department of Surgical Pathology, Department of Medical Oncology, and Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Gastrointestinal stromal tumors (GISTs) represent 1% of alimentary tract neoplasms. Up to 90% of GISTs are driven by activating mutations in tyrosine kinase or α genes. Imatinib mesylate is a tyrosine kinase inhibitor that has recently been used in a neoadjuvant role for locally advanced GIST. Read More

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http://dx.doi.org/10.6004/jnccn.2018.7063DOI Listing
December 2018
1 Read

Gastric sub-epithelial tumors: identification of gastrointestinal stromal tumors using CT with a practical scoring method.

Gastric Cancer 2018 Dec 9. Epub 2018 Dec 9.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objectives: To determine CT features that can identify gastrointestinal stromal tumors (GISTs) among gastric sub-epithelial tumors (SETs) and to explore a practical scoring method.

Methods: Sixty-four patients with gastric SETs (51 GISTs and 13 non-GISTs) from hospital I were included for primary analyses, and 92 (67 GISTs and 25 non-GISTs) from hospital II constituted a validation cohort. Pre-operative CT images were reviewed for imaging features: lesion location, growth pattern, lesion margin, enhancement pattern, dynamic pattern, attenuation at each phasic images and presence of necrosis, superficial ulcer, calcification, and peri-lesion enlarged lymph node (LN). Read More

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http://dx.doi.org/10.1007/s10120-018-00908-6DOI Listing
December 2018
1 Read

[Analysis of biological characteristics and prognosis on gastrointestinal stromal tumor with PDGFRA gene mutation].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1280-1284

Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital and Institute, Beijing 100142, China.Email:

Objective: To investigate the biological behavior characteristics of gastrointestinal stromal tumors (GIST) with PDGFRA mutation and the patients' survival, and elucidate the efficacy of imatinib therapy.

Methods: Patients with PDGFRA D842V and non-D842V mutations were screened from a database of 1163 patients with GIST who were treated at Peking University Cancer Hospital from 2003 to 2018. Clinicopathological data of these patients were collected, including gender, age, tumor size, mitotic phase, primary position, metastatic site, and expressions of CD117, CD34, DOG-1. Read More

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November 2018
15 Reads

[Analysis of clinical features and prognostic factors on reoperation patients with postoperative recurrence or metastasis of gastrointestinal stromal tumor].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1274-1279

Ward III Gastrointestinal Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai 200025,

Objective: To investigate the clinical characteristics and prognostic factors of reoperation patients with postoperative recurrence or metastasis of gastrointestinal stromal tumor (GIST).

Methods: A retrospective case-control study was performed on the clinical data of 31 patients with GIST who had recurrence or metastasis after the first surgery and underwent one or more operations again from February 2003 to January 2016 at Ruijin Hospital, Shanghai Jiaotong University School of Medicine. The clinical characteristics of these patients were analyzed. Read More

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November 2018
2 Reads

[Imaging characteristics of gastrointestinal neoplastic acute abdomen].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1223-1229

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Read More

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November 2018
1 Read

Recent advances in TMEM16A: Structure, function, and disease.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, China.

TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium-activated chloride channels, with ten transmembrane segments. Recently, atomic structures of the transmembrane domains of mouse TMEM16A (mTMEM16A) were determined by single-particle electron cryomicroscopy. This gives us a solid ground to discuss the electrophysiological properties and functions of TMEM16A. Read More

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http://dx.doi.org/10.1002/jcp.27865DOI Listing
December 2018
3 Reads

Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis.

World J Surg Oncol 2018 Dec 3;16(1):231. Epub 2018 Dec 3.

Department of Pathology, Phramongkutklao College of Medicine, Bangkok, Thailand.

Objective: This study aimed to understand clinicopathological characteristics of gastrointestinal stromal tumors (GISTs) and correlation between pathologic features and clinical outcome.

Methods: We used 76 cases diagnosed as primary GISTs during January 2007 to July 2017 at Army Institute of Pathology, Thailand. Clinical, survival, and pathological data were collected and analyzed. Read More

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http://dx.doi.org/10.1186/s12957-018-1532-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277996PMC
December 2018
2 Reads

Surgery for Gastrointestinal Stromal Tumors: State of the Art of Laparoscopic Resection and Surgery for M1 Tumors.

Visc Med 2018 Oct 3;34(5):367-374. Epub 2018 Oct 3.

Division of Surgical Oncology and Thoracic Surgery, Department of Surgery, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.

Background: The principles of surgery for primary gastrointestinal stromal tumor (GIST) are resection with clear margins without lymphadenectomy, thus enabling organ-preserving resection in many cases. Tumor rupture needs to be avoided, because it entails peritoneal sarcomatosis. Given these preconditions, there is a rationale for laparoscopic resection of primary GIST. Read More

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http://dx.doi.org/10.1159/000491799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257156PMC
October 2018
1 Read

Neoadjuvant Therapy to Downstage the Extent of Resection of Gastrointestinal Stromal Tumors.

Visc Med 2018 Oct 9;34(5):359-365. Epub 2018 Oct 9.

Division of Surgical Oncology and Thoracic Surgery, Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Introduction: Gastrointestinal stromal tumors (GIST) are rare malignant tumors in terms of incidence, and they are not linked to specific symptoms. Often, primary tumors, particularly of the stomach, rectum, or rectovaginal space, are quite large when detected, and multivisceral resection seems to be the treatment of choice as the mainstay of therapy is complete tumor removal. If a gain-of-function mutation in the gene is present, drug therapy with receptor tyrosine kinase inhibitors (RTKIs) might significantly downstage primary GIST tumors. Read More

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http://dx.doi.org/10.1159/000493405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257203PMC
October 2018
11 Reads

Clinical Presentation of Gastrointestinal Stromal Tumors.

Visc Med 2018 Oct 13;34(5):335-340. Epub 2018 Oct 13.

Division of Surgical Oncology, Mannheim University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. They constitute 1-2% of all gastrointestinal neoplasms but are the most common subtype of soft tissue sarcomas, accounting for 20-25%. In the late 1990s, GISTs were more and more recognized as a particular tumor entity. Read More

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http://dx.doi.org/10.1159/000494303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257088PMC
October 2018
1 Read

Laparoscopic and endoscopic cooperative surgery for gastric tumors: Perspective for actual practice and oncological benefits.

World J Gastrointest Oncol 2018 Nov;10(11):381-397

Department of Surgery, Shiga General Hospital, Moriyama 524-8524, Shiga, Japan.

Laparoscopic and endoscopic cooperative surgery (LECS) is a surgical technique that combines laparoscopic partial gastrectomy and endoscopic submucosal dissection. LECS requires close collaboration between skilled laparoscopic surgeons and experienced endoscopists. For successful LECS, experience alone is not sufficient. Read More

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http://www.wjgnet.com/1948-5204/full/v10/i11/381.htm
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http://dx.doi.org/10.4251/wjgo.v10.i11.381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247108PMC
November 2018
12 Reads

Clinicopathological features and prognosis of 276 cases of primary small (≤ 2 cm) gastric gastrointestinal stromal tumors: a multicenter data review.

Surg Endosc 2018 Nov 27. Epub 2018 Nov 27.

Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Background: Till present, there are still controversies over the epidemiology, pathological features, types of surgical treatment, and prognoses of primary small gastric GISTs (gGISTs).

Methods: From January 1998 to January 2015, patients with primary small gGIST admitted from four high-volume medical centers of the Southern China were enrolled and their data were analyzed to evaluate their clinicopathological features, treatment and prognostic factors to provide evidence-based medical experience for clinical practice.

Results: A total of 276 primary small gGIST cases over a period of 18 years were investigated and had a median age of 60 years (range 27-91 years old). Read More

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http://dx.doi.org/10.1007/s00464-018-6564-7DOI Listing
November 2018

[Contrastive analysis of ultrasonographic features of synchronous and heterochronic liver metastasis in patients with stromal tumor].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):829-832

Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for cancer, Tianjin 300060, China.

To investigate the ultrasonographic features of synchronous and heterochronic liver metastasis in patients with stromal tumors, and to elucidate the value of ultrasonic examination in follow-up surgery. A total of 1 516 patients with pathologically confirmed gastrointestinal stromal tumors (GISTs) and extra-gastrointestinal stromal tumors (EGISTs) were enrolled. The ultrasonographic features of primary lesions and liver metastases in a total of 46 cases with 95 liver metastases were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.11.006DOI Listing
November 2018
2 Reads

Usefulness of the thread-traction method in endoscopic full-thickness resection for gastric submucosal tumor: a comparative study.

Surg Endosc 2018 Nov 19. Epub 2018 Nov 19.

Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Mid Yanchang Road, Shanghai, 200072, China.

Background: Endoscopic full-thickness resection (EFTR) has shown great prospects in treating gastric submucosal tumors (SMTs) from the muscularis propria. However, it is very difficult sometimes to ideally expose the tumor and gain adequate visualization for the dissection site. In the present study, we applied the thread-traction (TT) method to assist EFTR in treating gastric SMTs and investigated the feasibility and effectiveness of this strategy. Read More

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http://dx.doi.org/10.1007/s00464-018-6585-2DOI Listing
November 2018
11 Reads
3.256 Impact Factor

Comparison of treatment outcomes between laparoscopic and endoscopic surgeries for relatively small gastric gastrointestinal stromal tumors.

Surg Oncol 2018 Dec 2;27(4):737-742. Epub 2018 Oct 2.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu province, 210029, China. Electronic address:

Background: Complete surgical resection remains the predominant treatment modality for primary gastrointestinal stromal tumors (GISTs). No therapeutic consensus exists for 2-5 cm gastric GISTs. We compared the efficacy, safety, and prognosis of laparoscopic and endoscopic surgeries in the treatment of relatively small (2-5 cm) intraluminal gastric GISTs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09607404183014
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http://dx.doi.org/10.1016/j.suronc.2018.10.002DOI Listing
December 2018
10 Reads
3.270 Impact Factor

Clinicopathological characteristics and prognosis of primary appendiceal stromal tumors.

World J Surg Oncol 2018 Nov 16;16(1):225. Epub 2018 Nov 16.

Department of Gastric Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, People's Republic of China.

Background: Gastrointestinal stromal tumors (GISTs) account for less than 1% of all gastrointestinal tumors. The biological behaviors of GISTs vary from benign to malignant. GISTs are common in the stomach (55. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
Publisher Site
http://dx.doi.org/10.1186/s12957-018-1524-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240235PMC
November 2018
13 Reads

Preoperative monocyte-to-lymphocyte ratio predicts recurrence in gastrointestinal stromal tumors.

J Surg Oncol 2019 Jan 13;119(1):12-20. Epub 2018 Nov 13.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Background And Objectives: Several inflammation markers were found to have a prognostic value in cancer. We investigated the significance of preoperative white cell ratios in determining gastrointestinal stromal tumors (GISTs) outcome.

Methods: Clinicopathological features of patients who underwent surgery for GIST were reviewed. Read More

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http://doi.wiley.com/10.1002/jso.25290
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http://dx.doi.org/10.1002/jso.25290DOI Listing
January 2019
12 Reads

A Ruptured Metastatic Hepatic Gastrointestinal Stromal Tumor Treated by Angiographic Embolization.

Korean J Gastroenterol 2018 Oct;72(4):205-208

Department of Radiology, Dongguk University Ilsan Hospital, Goyang, Korea.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract and occur most frequently in the stomach. The liver is the most common metastatic site of a GIST, and spontaneous rupture of the hepatic metastasis of a malignant gastric GIST is rare. We report the case of a 70-year-old man who presented with sudden right lower quadrant abdominal pain and was diagnosed with a spontaneously ruptured hepatic metastasis of a malignant gastric GIST. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4166/kjg.2018.72
Publisher Site
http://dx.doi.org/10.4166/kjg.2018.72.4.205DOI Listing
October 2018
11 Reads

Surgical and medical management of small bowel gastrointestinal stromal tumors: A report of the Dutch GIST registry.

Eur J Surg Oncol 2019 Mar 16;45(3):410-415. Epub 2018 Oct 16.

University of Groningen, University Medical Center Groningen, Department of Surgical Oncology, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands. Electronic address:

Background: A cohort of 201 patients with small bowel gastrointestinal stromal tumors (GIST) treated between January 1st, 2009 and December 31st, 2016 in five GIST expertise centers in the Netherlands was analyzed. Goal of this study was to describe the clinical, surgical and pathological characteristics of this rare subpopulation of GIST patients, registered in the Dutch GIST registry.

Methods: Clinical outcomes and risk factors of patients with small bowel GIST who underwent surgery or treated with systemic therapy were analyzed. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.09.013DOI Listing
March 2019
12 Reads

Gastric carcinoma with a gastrointestinal stromal tumor - A case report and literature review.

Med Sci (Paris) 2018 Oct 7;34 Focus issue F1:15-19. Epub 2018 Nov 7.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute   - Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Heping District, Tianjin 300052, China.

Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was diagnosed with gastric antrum adenocarcinoma accompanied by neuroendocrine differentiation and a GIST in the fundus, according to a preoperative examination and postoperative pathology. The patient then underwent a distal radical gastrectomy and GIST resection. Read More

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https://www.medecinesciences.org/10.1051/medsci/201834f103
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http://dx.doi.org/10.1051/medsci/201834f103DOI Listing
October 2018
12 Reads