2,996 results match your criteria Gastric Gastrointestinal Stromal Tumors


Robotic surgery for gastric gastrointestinal stromal tumors: A single center case series.

J Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Academic Surgery, Sarcoma, Melanoma and Rare Tumours Unit, The Royal Marsden Hospital, London, UK.

Background And Objectives: The aim of surgical treatment of gastrointestinal stromal tumors (GIST) is a microscopically complete resection. Initial indications for laparoscopic surgery were limited to smaller tumors, in favorable locations. Over time, indications for minimal invasive surgery (MIS) have expanded, however concerns remain when considering resection of larger GISTs. Read More

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http://dx.doi.org/10.1002/jso.26053DOI Listing

Laparoscopic gastrectomy with lymph node dissection for the treatment of remnant stomach gastrointestinal stromal tumors in incomplete-type Carney's triad: a case report.

Surg Case Rep 2020 May 24;6(1):112. Epub 2020 May 24.

Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2 Kobeshi, Chuou-ku, Kusunoki-cho, Kobe, Hyogo, 650-0017, Japan.

Background: We report a rare case of gastrointestinal stromal tumors (GISTs) in Carney's triad, successfully treated using laparoscopic gastrectomy with lymph node dissection after chemotherapy.

Case Presentation: A 21-year-old woman presented to our hospital for treatment of recurrent GISTs. The patient had been admitted for treatment 11 years prior, with black stools being the chief presenting complaint at that time. Read More

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http://dx.doi.org/10.1186/s40792-020-00877-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246277PMC

Clinicopathologic and Surgical Characteristics Study of 151 Cases of GIST.

J Gastrointest Cancer 2020 May 22. Epub 2020 May 22.

Department of General Surgery, Necmettin Erbakan University Meram Medicine Faculty, Konya, Turkey.

Background: Gastrointestinal stromal tumor (GIST) is the most appearing mesenchymal tumor of the gastrointestinal system. In this study, we are aiming to share the most up to date knowledge about diagnosis and treatment of these tumors by transferring our clinical experience about GISTs.

Methods: The 151 patients who were operated between 2006-2020 and whose pathological examination was reported as GIST were analyzed retrospectively. Read More

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http://dx.doi.org/10.1007/s12029-020-00414-yDOI Listing

Difference in Perfusion Parameters Between Gastric Cancer and Gastric Stromal Tumors: Evaluation With Oral Contrast Plus Contrast-Enhanced Ultrasonography.

Front Oncol 2020 5;10:532. Epub 2020 May 5.

Department of Ultrasound, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

To explore the difference of perfusion parameters between gastric cancer (GC) and gastric stromal tumors (GSTs) by using oral contrast plus contrast-enhanced ultrasonography (OC+CEUS). We retrospectively reviewed 149 patients with histologically confirmed gastric lesions (80 patients with GC and 69 patients with GST). OC+CEUS was performed in all patients in the GC group and the GST group before surgery. Read More

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http://dx.doi.org/10.3389/fonc.2020.00532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214801PMC

Comparison of endoscopic versus laparoscopic resection for gastric gastrointestinal stromal tumors: a preliminary meta-analysis.

J Gastroenterol Hepatol 2020 May 19. Epub 2020 May 19.

Medical Centre for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Background And Aim: For localized disease, complete surgical resection is regarded as the "Gold Standard" therapeutic modality. With the rapid development of endoscopic techniques, endoscopic resection (ESR) has been confirmed as an efficient and safe alternative for the treatment of gastrointestinal stromal tumors (GISTs) in the stomach. Nevertheless, the management of gastric GISTs remains poorly defined. Read More

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http://dx.doi.org/10.1111/jgh.15106DOI Listing

Clinical course of suspected small gastrointestinal stromal tumors in the stomach.

World J Gastrointest Surg 2020 Apr;12(4):171-177

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Gastric subepithelial lesions are frequently encountered during endoscopic examinations, and the majority of them are small and asymptomatic. Among these lesions, gastrointestinal stromal tumors (GISTs) are the major concern for patients and clinicians owing to their malignant potentials. Although previous guidelines suggested periodic surveillance for such small (≤ 20 mm) lesions, several patients and clinicians have still requested or prescribed repeated examinations or radical resection, posing extra medical burdens and risks. Read More

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http://dx.doi.org/10.4240/wjgs.v12.i4.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215971PMC

Clinicopathologic characteristics, diagnostic clues, and prognoses of patients with multiple sporadic gastrointestinal stromal tumors: a case series and review of the literature.

Diagn Pathol 2020 May 14;15(1):56. Epub 2020 May 14.

Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, People's Republic of China.

Background: Most sporadic gastrointestinal stromal tumors (GISTs) occur as solitary tumors, while multiple sporadic GISTs are extremely rare and often misdiagnosed as metastatic GISTs, leading to inappropriate treatment. This study aimed to investigate the clinicopathological characteristics, diagnostic clues, and prognoses of multiple sporadic GISTs.

Methods: Twenty-seven patients with multiple sporadic GISTs and 11 patients with metastatic GISTs mimicking sporadic GISTs were analyzed. Read More

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http://dx.doi.org/10.1186/s13000-020-00939-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222320PMC

Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of the gastrointestinal stromal tumor of the stomach.

Diagn Cytopathol 2020 May 13. Epub 2020 May 13.

Anatomical Pathology Service, Marqués de Valdecilla University Hospital, University of Cantabria and IDIVAL Research Institute, Santander, Spain.

Background: This study aims to evaluate the usefulness of endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) in the diagnosis of the gastric gastrointestinal stromal tumor (GIST).

Methods: We retrospectively investigated the efficacy and accuracy of EUS-FNAC in the diagnosis of gastric GIST. Cytological smears and cytoblock sections including immunohistochemistry and mutational studies from patients diagnosed as gastric GISTs were retrieved. Read More

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http://dx.doi.org/10.1002/dc.24442DOI Listing

Modified endoscopic full-thickness resection of gastric stromal tumor originating from the muscularis propria layer.

J Gastrointest Oncol 2020 Apr;11(2):461-466

Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing 400030, China.

Endoscopic full-thickness resection (EFTR) is emerging as an approach to resect gastric gastrointestinal stromal tumors originating from the muscularis propria layer (MP-GISTs) because several established endoscopic closure methods and tools have been developed. However, EFTR is performed difficultly due to three challenges: limited luminal insufflation and visualization, insufficient operating space, and inadequate exposure of cutting line. Therefore, we performed a novel method of clip- and snare-assisted EFTR (also named as m-EFTR or chen-EFTR) to resect a MP-GIST. Read More

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http://dx.doi.org/10.21037/jgo.2020.03.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212117PMC

Which size is the best cutoff for primary small gastric gastrointestinal stromal tumor?

J Gastrointest Oncol 2020 Apr;11(2):402-410

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China.

Background: The biological behavior of primary small gastric gastrointestinal stromal tumor (gGIST) is indolent. The cutoff size categorizing small gGIST continues to be controversial. To date, there is no consensus regarding whether it should be 1 cm, 2 cm, or another size. Read More

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http://dx.doi.org/10.21037/jgo.2020.03.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212102PMC

A rare case of jejunal gastrointestinal stromal tumor.

Ann Ital Chir 2019 Dec 20;8. Epub 2019 Dec 20.

Gastrointestinal stromal tumors(GISTs) are rare neoplasms of the gastrointestinal(GI) system originating from the mesenchyme. GISTs mostly develop in the stomach and small intestine. We present here a case of jejunal GIST which is the rarest subtype. Read More

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December 2019

Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors.

J Clin Med 2020 May 1;9(5). Epub 2020 May 1.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

There have been no comparative studies investigating the results of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients with gastric mesenchymal tumors, including leiomyomas, leiomyosarcomas, schwannomas, and gastrointestinal stromal tumors (GISTs). We retrospectively reviewed the data of 142 patients with pathologically diagnosed gastric mesenchymal tumors treated at 11 institutions. We analyzed the correlation between the maximum standardized uptake value (SUVmax) evaluated using fluorodeoxyglucose-positron emission tomography (FDG-PET) and the tumor size. Read More

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http://dx.doi.org/10.3390/jcm9051301DOI Listing

Recent Anti-platelet Therapy Revealing Underlying Undiagnosed Gastrointestinal Stromal Tumor in Otherwise Healthy Patient.

Cureus 2020 Mar 28;12(3):e7450. Epub 2020 Mar 28.

Gastroenterology, BronxCare Health System, Bronx, USA.

Gastrointestinal stromal tumors (GIST) are uncommon tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. Usually, GIST presents as chronic gastrointestinal symptoms or obscure gastrointestinal bleed. Not many cases have been reported in the literature with acute symptoms in the setting of recent aspirin use. Read More

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http://dx.doi.org/10.7759/cureus.7450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186083PMC

Retroperitoneal teratoma misdiagnosed as a gastric stromal tumor: A case report.

Mol Clin Oncol 2020 Jun 19;12(6):525-528. Epub 2020 Mar 19.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.

The misdiagnosis of retroperitoneal teratoma as a gastric stromal tumor is rarely reported. There are numerous abdominal organs, and retroperitoneal tumors are easily concealed by organs situated more anteriorly on the abdomen; therefore, retroperitoneal tumors are easily misdiagnosed as human digestive system tumors by abdominal surgeons. We herein present the case of a 39-year-old female patient who was diagnosed with a gastric stromal tumor (GST) on preoperative examination, whereas the postoperative diagnosis was retroperitoneal mature cystic teratoma. Read More

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http://dx.doi.org/10.3892/mco.2020.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179382PMC

Characteristic of extra luminal gastric stromal tumor arising from the lesser curvature of the stomach: A case report.

Medicine (Baltimore) 2020 Apr;99(16):e19885

Department of Gastroenterology.

Rationale: Gastrointestinal stromal tumor (GIST) is one of the most common malignant mesenchymal tumors of the gastrointestinal tract. They generally arise from the fourth layer (muscularis propria) and rarely from the second or third layer. Although the manifestations of gastric stromal tumors are diverse, to our knowledge, there are only several cases of an extra-gastric stromal tumor in the literature appearing with a pedunculation. Read More

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http://dx.doi.org/10.1097/MD.0000000000019885DOI Listing

Transanal versus nontransanal surgery for the treatment of primary rectal gastrointestinal stromal tumors: a 10-year experience in a high-volume center.

Ann Transl Med 2020 Mar;8(5):201

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

Background: Rectal gastrointestinal stromal tumor (GIST) is a rare digestive disease that has a distinct malignant tendency compared to that of gastric-derived GIST. At present, there is still no standard, and the surgical approach to rectal GIST is controversial.

Methods: The clinicopathological data and prognosis of rectal GIST patients admitted to the Sixth Affiliated Hospital of Sun Yat-sen University from 1998. Read More

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http://dx.doi.org/10.21037/atm.2020.01.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154442PMC

[Comparison of short-term efficacy between robotic and 3D laparoscopic-assisted D2 radical distal gastrectomy for gastric cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Apr;23(4):350-356

School of Medicine, Nankai University, Tianjin 300071, China; Department of General Surgery, Institute of General Surgery, Chinese PLA General Hospital, Beijing 100853, China.

To compare short-term efficacy of robotic versus 3D laparoscopic-assisted D2 radical distal gastrectomy in gastric cancerpatients and those with different body mass index (BMI). A retrospective cohort study was performed. Inclusion criteria:(1) gastric cancer proved by preoperative pathological results and tumor location was suitable for D2 radical distal gastrectomy; (2) no distal metastases such as in liver, kidney or abdominal cavity, and no direct invasion to the pancreas or colon on preoperative imaging; (3) postoperative pTNM stage ranged from I to III; (4) no conversion to open surgery or change of surgical procedure during operation; (5) complete clinicopathological data. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200224-00085DOI Listing

Spectrum of activity of dasatinib against mutant KIT kinases associated with drug-sensitive and drug-resistant gastrointestinal stromal tumors.

Gastric Cancer 2020 Apr 6. Epub 2020 Apr 6.

CAS Key Laboratory of Tissue Microenvironment and Tumor, SINH-Changzheng Hospital Joint Center for Translational Medicine, Institutes for Translational Medicine (CAS-SMMU), Changzheng Hospital, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, People's Republic of China.

Background: The majority of GISTs express mutationally activated KIT. Imatinib and sunitinib are approved KIT-inhibiting therapies. Their efficacy is usually hampered by the acquired multiple secondary drug-resistance KIT mutations. Read More

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http://dx.doi.org/10.1007/s10120-020-01069-1DOI Listing

[Acute complications of gastrointestinal stromal tumors].

Khirurgiia (Mosk) 2020 (3):67-73

Chita State Medical Academy of the Ministry of Health of Russia, Chita, Russia.

Objective: To analyze acute complications of stromal gastrointestinal tumors and determine diagnosis and optimal treatment of these patients.

Material And Methods: There were 33 patients with acute complications of GIST aged 40-74 years.

Results: Acute complications were presented by gastrointestinal and (or) intratumoral (interstitial) bleeding (n=31). Read More

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http://dx.doi.org/10.17116/hirurgia202003167DOI Listing

Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors.

J Gastric Cancer 2020 Mar 27;20(1):29-40. Epub 2019 Dec 27.

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either or platelet-derived growth factor receptor A () and are highly responsive to several selective tyrosine kinase inhibitors. In this study, a targeted next-generation sequencing (NGS) assay with an Oncomine Focus Assay (OFA) panel was used for the genetic characterization of molecular targets in 30 Korean patients with GIST.

Materials And Methods: Using the OFA that enables rapid and simultaneous detection of hotspots, single nucleotide variants (SNVs), insertion and deletions (Indels), copy number variants (CNVs), and gene fusions across 52 genes relevant to solid tumors, targeted NGS was performed using genomic DNA extracted from formalin-fixed and paraffin-embedded samples of 30 GISTs. Read More

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http://dx.doi.org/10.5230/jgc.2020.20.e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105413PMC

Preoperative adjuvant therapy for locally advanced and recurrent/metastatic gastrointestinal stromal tumors: a retrospective study.

World J Surg Oncol 2020 Apr 7;18(1):70. Epub 2020 Apr 7.

Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, People's Republic of China.

Background: Preoperative imatinib mesylate therapy for gastrointestinal stromal tumors (GISTs) is controversial. This study aimed to explore the clinical efficacy and optimal duration of preoperative imatinib mesylate (IM) therapy in patients with locally advanced and recurrent/metastatic GISTs.

Methods: We retrospectively examined patients who received preoperative imatinib mesylate therapy from January 2013 to December 2018 at Xiangya Hospital, Central South University and the Second Xiangya Hospital of Central South University, China. Read More

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http://dx.doi.org/10.1186/s12957-020-01840-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140320PMC

Difference of computed tomographic characteristic findings between gastric and intestinal gastrointestinal stromal tumors.

Jpn J Radiol 2020 Apr 4. Epub 2020 Apr 4.

Department of Radiology, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Purpose: We aimed to compare the computed tomography (CT) imaging differences between gastric and intestinal gastrointestinal stromal tumors (GISTs).

Materials And Methods: Thirty-eight patients with 38 gastric GISTs and 27 with 31 intestinal GISTs were enrolled. Tumors were classified as small (< 5 cm) or large (≥ 5 cm). Read More

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http://dx.doi.org/10.1007/s11604-020-00962-0DOI Listing

Gastrointestinal Stromal Tumours (GIST) in Young Adult (18-40 Years) Patients: A Report from the Dutch GIST Registry.

Cancers (Basel) 2020 Mar 20;12(3). Epub 2020 Mar 20.

Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Gastrointestinal stromal tumour (GIST) is a disease of older adults and is dominated by / mutations. In children, GIST is rare, predominantly occurs in girls, has a stomach location and generally lacks / mutations. For young adults (YA), aged 18 to 40 years, the typical phenotypic and genotypic patterns are unknown. Read More

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http://dx.doi.org/10.3390/cancers12030730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140070PMC

Quality of Surgery and Outcome in Localized Gastrointestinal Stromal Tumors Treated Within an International Intergroup Randomized Clinical Trial of Adjuvant Imatinib.

JAMA Surg 2020 Apr 1:e200397. Epub 2020 Apr 1.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Importance: The association between quality of surgery and overall survival in patients affected by localized gastrointestinal stromal tumors (GIST) is not completely understood.

Objective: To assess the risk of death with and without imatinib according to microscopic margins status (R0/R1) using data from a randomized study on adjuvant imatinib.

Design, Setting, And Participants: This is a post hoc observational study on patients included in the randomized, open-label, phase III trial, performed between December 2004 and October 2008. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.0397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113837PMC

Treatment of a Gastrointestinal Stromal Tumor (GIST) Adherent to the Spleen and the Tail of the Pancreas: A Case Report.

Am J Case Rep 2020 Mar 31;21:e918278. Epub 2020 Mar 31.

3rd Surgical Department, University Hospital of Thessaloniki AHEPA, Thessaloniki, Greece.

BACKGROUND Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal gastrointestinal tumors (GIT). Usually, they appear in patients ages 55-65 years, with no apparent difference between males and females. Their annual incidence is about 11-14 per 10⁶. Read More

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http://dx.doi.org/10.12659/AJCR.918278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161921PMC

Outcomes of Gastric Resection in the Establishment of a Comprehensive Oncologic Robotic Program.

J Surg Res 2020 Mar 26;252:30-36. Epub 2020 Mar 26.

H. Lee Moffitt Cancer Center & Research Institute, Department of Gastrointestinal Oncology, Tampa, Florida. Electronic address:

Background: Robotic-assisted gastrectomy is increasingly utilized for the treatment of gastric malignancies. However, the benefits of robotic surgery have been questioned. This study describes short-term outcomes in the establishment of a comprehensive robotic program for gastric malignancies. Read More

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http://dx.doi.org/10.1016/j.jss.2020.01.023DOI Listing

Minimally invasive options for gastrointestinal stromal tumors of the stomach.

Surg Endosc 2020 Mar 27. Epub 2020 Mar 27.

Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA.

Background: Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors, most commonly arising in the stomach. Surgical resection remains the mainstay of cure, and can often be accomplished laparoscopically. Tumor size and location guide selection of appropriate resection technique. Read More

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http://dx.doi.org/10.1007/s00464-020-07510-xDOI Listing

Clinical outcomes of tumor bleeding in duodenal gastrointestinal stromal tumors: a 20-year single-center experience.

Surg Endosc 2020 Mar 13. Epub 2020 Mar 13.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

Background: Duodenal gastrointestinal stromal tumors (GISTs) are rare, and reports on duodenal GIST bleeding are few. We analyzed the risk factors and clinical outcomes of hemorrhagic duodenal GISTs and compared them with those of gastric GISTs.

Methods: Primary duodenal GISTs surgically diagnosed between January 1998 and December 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00464-020-07486-8DOI Listing

[A Case of Laparoscopic Local Resection of the Stomach for an Inflammatory Myofibroblastic Tumor].

Gan To Kagaku Ryoho 2019 Dec;46(13):2054-2056

Dept. of Surgery, Funabashi Chuo Hospital.

A 52-year-old man underwent upper gastrointestinal endoscopy screening that identified a submucosal tumor in the gastric fornix, and a solid tumor with a maximum diameter of 35mm was suspected based on abdominal computed tomography. An endoscopic ultrasound-guided fine needle aspiration biopsy showed spindle-shaped cells with KIT, CD34, desmin, and S-100 all testing negative. Based on the diagnosis of a gastrointestinal stromal tumor, subtotal gastrectomy was performed laparoscopically. Read More

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December 2019

[A Case of Inverted LECS for GIST in the Remnant Stomach after Distal Gastrectomy].

Gan To Kagaku Ryoho 2019 Dec;46(13):1954-1956

Dept. of Surgery, Tsuyama Chuo Hospital.

Laparoscopy and endoscopy cooperative surgery(LECS)is the surgical procedure used to avoid excessive resection of the gastrointestinal wall and preserve its function. We report the case of a patient who was successfully treated with inverted LECS for gastrointestinal stromal tumor(GIST)in the remnant stomach and underwent distal gastrectomy. The patient was a 75- year-old man who received distal gastrectomy for gastric ulcer 28 years before. Read More

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December 2019

[LECS-Assisted Open Partial Gastrectomy for an Ulcerative GIST in an Elderly Patient].

Gan To Kagaku Ryoho 2019 Dec;46(13):2577-2579

Dept. of Surgery, Red Cross Kyoto Daiichi Hospital.

Laparoscopy and endoscopy cooperative surgery(LECS)is an excellent surgical procedure that prevents excessive resection of the gastrointestinal wall and maintains gastrointestinal functions. However, LECS is not recommended for large gastrointestinal stromal tumor(GIST)sized more than 5 cm and/or ulcerative GIST because of the oncological risk of peritoneal dissemination. Here, we report the case of an elderly patient who was successfully treated with LECS-assisted open partial gastrectomy for an ulcerative GIST near the esophagogastric junction. Read More

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December 2019

[A Case of Laparoscopic Gastric Local Resection for Simultaneous Multiple Gastric GIST Discovered Owing to Gastrointestinal Bleeding].

Gan To Kagaku Ryoho 2019 Dec;46(13):2380-2382

Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.

An 80-year-old woman with anemia presented to our hospital. Upper gastrointestinal endoscopy revealed a 4 cm submucosal tumor(SMT)with a delle and 2 cm SMT in the upper part of the stomach. CT revealed sustained enhancement of both tumors. Read More

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December 2019

[A Clinical Study of Seven Cases of LECS for Gastric Submucosal Tumors].

Gan To Kagaku Ryoho 2019 Dec;46(13):2303-2305

Dept. of Surgery, Fukuoka Tokushukai Hospital.

Laparoscopy and endoscopy cooperative surgery(LECS)is a surgical technique to resect a tumor with minimal invasion, using both a laparoscope and endoscope. Twenty-eight surgeries for gastric submucosal tumors(SMT)were performed between 2009 and 2019. Seven of those cases were performed using LECS. Read More

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December 2019

Aberrant expression of Wnt/β-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors.

Eur J Surg Oncol 2020 Jun 26;46(6):1080-1087. Epub 2020 Feb 26.

Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan. Electronic address:

Introduction: Recent reports on gene expression profiling (GEP) show several genes associated with malignant progression of GIST. However, genes associated with malignant transformation have not been clarified. Here, we aimed to reveal distinct genes in aggressive malignant GIST, using comprehensive gene expression analysis. Read More

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http://dx.doi.org/10.1016/j.ejso.2020.02.036DOI Listing

Multiple heterochronic gastrointestinal stromal tumors in the stomach detected 6 years after resection: a case report.

Surg Case Rep 2020 Mar 7;6(1):48. Epub 2020 Mar 7.

Department of Gastroenterology, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: To date, only a few cases of multiple GISTs with different clones in different organs have been published. However, a case of multiple GISTs with different clones occurring in a single organ has never been reported.

Case Presentation: A 41-year-old patient underwent laparoscopic partial gastrectomy for gastric gastrointestinal stromal tumor (GIST) in 2012. Read More

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http://dx.doi.org/10.1186/s40792-020-00812-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060937PMC

Multiple gastrointestinal stromal tumors caused by a novel germline KIT gene mutation (Asp820Gly): a case report and literature review.

Gastric Cancer 2020 Mar 7. Epub 2020 Mar 7.

Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract; most of them have gain-of-function mutations of the KIT gene. There have been rare cases of families with multiple GISTs, that had autosomal dominant germline KIT mutations. Here, we present a case of multiple GISTs caused by a novel germline KIT mutation. Read More

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http://dx.doi.org/10.1007/s10120-020-01055-7DOI Listing

Mucosectomy device-assisted endoscopic resection of gastric subepithelial lesions.

J Dig Dis 2020 Apr 31;21(4):215-221. Epub 2020 Mar 31.

Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.

Objective: Some gastrointestinal subepithelial tumors (SETs) have malignant potential and complete resection may be required. However, endoscopic submucosal dissection (ESD) can be a tedious procedure and requires a long and extensive training to master. Devices for endoscopic full-thickness resection (EFTR) are limited and are not widely available. Read More

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http://dx.doi.org/10.1111/1751-2980.12856DOI Listing

Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor.

J Pathol Transl Med 2020 May 4;54(3):258-262. Epub 2020 Mar 4.

Department of Medical Gastroenterology, SRM Institutes for Medical Science, Vadapalani, India.

IgG4-related disease of the stomach is a rare disorder, and only a few cases have been reported. We present two cases that were identified over a 2-month period in our center. Two male patients aged 52 and 48 years presented with mass lesion in the stomach, which were clinically thought to be gastrointestinal stromal tumor, and they underwent excision of the lesion. Read More

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http://dx.doi.org/10.4132/jptm.2020.02.10DOI Listing

Endoscopic Ultrasound in Guiding Local Resection and Ampullary Preservation of a High-Risk Periampullary GIST.

Case Rep Gastrointest Med 2020 30;2020:8418905. Epub 2020 Jan 30.

Division of Gastroenterology & Hepatology, Department of Medicine, Univeristy of WIsconsin School of Medicine and Public Health, Madison, WI, USA.

Gastrointestinal stromal tumors (GISTs) typically develop in the stomach or small intestine and rarely involve the ampulla of Vater, with only 13 cases reported in the world literature since 2004. Most authors advocate performing pancreaticoduodenectomy for such lesions. However, this operation can carry higher rates of morbidity and mortality compared to local resection. Read More

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http://dx.doi.org/10.1155/2020/8418905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013300PMC
January 2020

[A novel and simplified closure method for defect closure after endoscopic full-thickness resection of gastric submucosal tumors: short-term outcomes of "Shao-Mai" closure method].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Feb;23(2):183-187

Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai Engineering and Research Center of Diagnostic and Therapeutic Endoscopy, Shanghai 200032, China.

To evaluate the feasibility and short-term efficacy of a novel and simplified closure method developed by our team for the defect closure after endoscopic full-thickness resection (EFTR) for gastric submucosal tumors (SMT) in the gastric wall. A prospective single-arm clinical study was used. Inclusion criteria: (1) the lesion was located in the fundus or the greater curvature of the stomach, and was confirmed to originate from the muscularis propria layer; (2) the diameter of the tumor was ≤3. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1671-0274.2020.02.015DOI Listing
February 2020

[Wild-type gastroinestinal stromal tumors].

Bull Cancer 2020 Apr 13;107(4):499-505. Epub 2020 Feb 13.

Gustave-Roussy Cancer Campus, département d'oncologie médicale, 114, rue Edouard-Vaillant, 94800 Villejuif, France. Electronic address:

Gastrointestinal stromal tumors (GIST) are the most common non-epithelial tumors of the gastrointestinal tract. Wild-type GISTs (WT-GIST) consist of a rare heterogeneous group characterized by the lack of activating mutations in the tyrosine kinase receptor (Kit) and/or platelet derived growth factor receptor A (PDGFRA). However, WT-GIST is characterized by other genomic alterations, including dehydrogenase succinate (SDH) deficiency or mutations in the Ras pathway. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.12.007DOI Listing

Clinicopathologic and immunohistochemical characteristics of upper gastrointestinal leiomyomas harboring interstitial cells of Cajal: A potential mimicker of gastrointestinal stromal tumor.

Ann Diagn Pathol 2020 Apr 5;45:151476. Epub 2020 Feb 5.

Koç University Hospital, Department of Pathology, Turkey.

Objective: To analyze clinicopathologic characteristics of upper gastrointestinal leiomyomas and to determine the distribution and immunohistochemical features of interstitial cells of Cajal, in order to designate whether they can cause diagnostic challenges.

Materials And Methods: Twenty-four upper gastrointestinal leiomyomas (14 esophagus, 10 stomach) were retrieved. CD117, DOG-1 and muscle markers were performed. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151476DOI Listing

Laparoscopic Transgastric Resection of a Gastrointestinal Stromal Tumor and Concomitant Sleeve Gastrectomy: a Case Report.

Obes Surg 2020 Apr;30(4):1596-1599

Department of General Surgery, Memorial Group/Medstar Antalya Hospital, Yıldız Mah. Çakırlar Cad. No:19, Muratpaşa, Antalya, Turkey.

Background: Incidences of obesity, obesity surgeries, and gastric submucosal tumors (GST) have increased worldwide. This case report aims to demonstrate that concomitant laparoscopic transgastric resection (LTGR) of a gastrointestinal stromal tumor (GIST) near the esophagogastric junction (EGJ) can be performed safely and effectively in a patient with morbid obesity and scheduled sleeve gastrectomy (SG).

Methods: The patient was planned to undergo SG surgery after the diagnosis of morbid obesity (BMI, 40. Read More

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http://dx.doi.org/10.1007/s11695-020-04472-wDOI Listing

Reasons for Diagnostic Failure in Forty-Five Consecutive Mucosal Cutting Biopsy Examinations of Gastric Subepithelial Tumors.

Clin Endosc 2020 Feb 14. Epub 2020 Feb 14.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Background/aims: Mucosal cutting biopsy (MCB) is useful for the histopathological diagnosis of gastric subepithelial tumors (SETs). However, there is little information on cases in which MCB did not establish a diagnosis. In the current study, we aimed to investigate the characteristics of cases in which MCB was unsuccessful. Read More

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http://dx.doi.org/10.5946/ce.2019.150DOI Listing
February 2020

Clinical significance of various growth factors in patients with different gastric neoplasms.

Am J Transl Res 2020 15;12(1):118-129. Epub 2020 Jan 15.

Department of Internal Medicine, University of Zielona Góra Poland.

Growth factors represent a family of important biological molecules that can also be critical in the pathogenesis of various gastrointestinal cancers. In this study, we conducted a comprehensive analysis of the systemic levels of selected growth factors - hepatocyte, vascular-endothelial, fibroblast, and insulin-like 1 growth factors (HGF, VEGF, FGF, and IGF-1, respectively), as well as granulocyte-colony stimulating factor (G-CSF) in 75 patients with different gastric neoplasms (carcinomas, gastrointestinal stromal tumors - GISTs, neuroendocrine neoplasms - NENs, and lymphomas) and 40 healthy volunteers. Patients with gastric carcinoma or other types of gastric neoplasms had higher HGF and IGF-1 levels than healthy individuals (P < 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013217PMC
January 2020