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Case Rep Gastroenterol 2020 May-Aug;14(2):299-305. Epub 2020 May 28.

Department of Gastroenterology, Faculty of Medicine, Ibn Al Jazzar, University Hospital of Sahloul, Sousse, Tunisia.

Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer. Liver cirrhosis of any etiology is considered the main risk factor for the development of HCC. However, HCC in noncirrhotic livers remains an uncommon finding. Read More

Clin J Gastroenterol 2020 Jun 27. Epub 2020 Jun 27.

Department of Gastroenterology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

The present case involved a 60-year-old man with autoimmune pancreatitis (AIP). While his AIP was in remission for 6 years, a follow-up CE-CT revealed a dilated main pancreatic duct (MPD) and an enhanced mural nodule. Fluorodeoxyglucose uptake was positive on positron emission tomography. Read More

Front Oncol 2020 10;10:780. Epub 2020 Jun 10.

Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China.

An accumulating body of evidence suggests that long non-coding RNAs (lncRNAs) can serve as potential cancer prognostic factors. However, the utility of lncRNA combinations in estimating overall survival (OS) for hepatocellular carcinoma (HCC) remains to be elucidated. This study aimed to construct a powerful lncRNA signature related to the OS for HCC to enhance prognostic accuracy. Read More

Cancers (Basel) 2020 Jun 17;12(6). Epub 2020 Jun 17.

Division of Cancer Prevention and Genetics, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, Italy.

E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium revised the clinical criteria and established guidelines for the genetic screening of CDH1 germline syndromes. Nevertheless, the introduction of multigene panel testing in clinical practice has led to an increased identification of E-cadherin mutations in individuals without a positive family history of gastric or breast cancers. Read More

Korean J Radiol 2020 Jul;21(7):793-811

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Surgical resection remains the primary choice of treatment and the only potentially curative option for gastric carcinoma, and is increasingly performed laparoscopically. Gastric resection represents a challenging procedure, with a significant morbidity and non-negligible postoperative mortality. The interpretation of imaging after gastric surgery can be challenging due to significant modifications of the normal anatomy. Read More

Case Rep Oncol 2020 May-Aug;13(2):538-543. Epub 2020 May 13.

Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

The presentation of submucosal gastric cancer, especially signet ring cell carcinoma, is rare. The submucosal tumor (SMT) is covered with normal mucosa, and confirmation is difficult through endoscopic biopsy; thus, histologic diagnosis is important to determine the appropriate treatment method. Here, we report a case of gastric signet ring cell carcinoma mimicking gastrointestinal stromal tumor (GIST). Read More

JGH Open 2020 Jun 29;4(3):472-476. Epub 2019 Nov 29.

Department of Gastroenterology, Sir Sunderlal Hospital, Institute of Medical Sciences Banaras Hindu University Varanasi India.

Background And Aim: Dysphagia can lead to substantial morbidity and mortality, especially in the elderly. It has both benign and malignant causes. Despite having a varied etiology, there have been few studies in India. Read More

Expert Rev Gastroenterol Hepatol 2020 Jun 17:1-18. Epub 2020 Jun 17.

Department of Surgical Oncology, Graduate School of Medicine, the University of Tokyo , Tokyo, Japan.

Introduction: Artificial intelligence (AI) that surpasses human ability in image recognition is expected to be applied in the field of gastrointestinal endoscopes. Accordingly, its research and development (R &D) is being actively conducted. With the development of endoscopic diagnosis, there is a shortage of specialists who can perform high-precision endoscopy. Read More

SLAS Discov 2020 Jun 2:2472555220929291. Epub 2020 Jun 2.

InSphero AG, Schlieren, Switzerland.

Three-dimensional (3D) spheroid models are rapidly gaining favor for drug discovery applications due to their improved morphological characteristics, cellular complexity, long lifespan in culture, and higher physiological relevance relative to two-dimensional (2D) cell culture models. High-content imaging (HCI) of 3D spheroid models has the potential to provide valuable information to help researchers untangle disease pathophysiology and assess novel therapies more effectively. The transition from 2D monolayer models to dense 3D spheroids in HCI applications is not trivial, however, and requires 3D-optimized protocols, instrumentation, and resources. Read More

Medicine (Baltimore) 2020 May;99(21):e20361

Department of Gastroenterology.

Introduction: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described entity that is characterized by well-differentiated neoplasm with unclear etiopathogenesis.

Patient Concerns: A 60-year-old Chinese man was referred to our hospital for abdominal distension.

Diagnosis: Esophagogastroduodenoscopy (EGD) showed a depressed lesion found using in the greater curvature of the stomach. Read More

Korean J Gastroenterol 2020 May;75(5):264-291

Department of Gastroenterology, Korea University Anam Hospital, Seoul, Korea.

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a standard treatment for early gastrointestinal cancers without regional lymph node metastasis. High-definition white light endoscopy, chromoendoscopy, and image-enhanced endoscopy such as narrow band imaging are performed to assess the edge and depth of early gastrointestinal cancers for delineation of resection boundaries and prediction of the possibility of lymph node metastasis before the decision of endoscopic resection. Endoscopic mucosal resection and/or endoscopic submucosal dissection can be performed to remove early gastrointestinal cancers completely by fashion. Read More

Methods 2020 May 19. Epub 2020 May 19.

Department of Computer Science, University of Nevada, Las Vegas, NV, USA. Electronic address:

Digitizing whole-slide imaging in digital pathology has led to the advancement of computer-aided tissue examination using machine learning techniques, especially convolutional neural networks. A number of convolutional neural network-based methodologies have been proposed to accurately analyze histopathological images for cancer detection, risk prediction, and cancer subtype classification. Most existing methods have conducted patch-based examinations, due to the extremely large size of histopathological images. Read More

Cureus 2020 Apr 17;12(4):e7707. Epub 2020 Apr 17.

2nd Department of Surgery, "Aretaeio" Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.

Serous cystadenocarcinoma of the pancreas is a rare but well-established entity. The origin and evolution of this disorder remain unclear, but even metastatic cases have an excellent prognosis. These tumors are very similar to benign serous cystic neoplasms (SCNs) of the pancreas, except that they tend to be larger, are locally invasive, and present distant metastasis. Read More

Chin J Cancer Res 2020 Apr;32(2):197-207

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

Objective: Peritoneal dissemination is difficult to diagnose by conventional imaging technologies. We aimed to construct a nomogram to predict peritoneal dissemination in gastric cancer (GC) patients.

Methods: We retrospectively analyzed 1,112 GC patients in Sun Yat-sen University Cancer Center between 2001 and 2010 as the development set and 474 patients from The Sixth Affiliated Hospital, Sun Yat-sen University between 2010 and 2016 as the validation set. Read More

Surg Clin North Am 2020 Jun 18;100(3):523-534. Epub 2020 Mar 18.

Division of Endocrine and Surgical Oncology, Department of Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4637 JCP, Iowa City, IA 52242, USA. Electronic address:

Gastric cancer is one of the most common cancers in the world, despite declining incidence of the disease in the United States. Because of the rare occurrence of the disease in the United States, there is significant treatment variance in use of diagnostic modalities, neoadjuvant/adjuvant therapies, and surgical techniques. The survival of patients with gastric cancer in the United States is significantly lower than those of Asian countries where the diagnosis is made at an earlier stage and uniform high-quality treatment is delivered. Read More

Nanotoxicology 2020 May 13:1-14. Epub 2020 May 13.

The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Gastric carcinoma is one of the most lethal malignant tumors. As part of our long-term efforts on seeking effective diagnosis and therapeutic strategies of gastric cancer, we present herein novel ternary copper-based chalcogenide nanoplatform CuS-NiS nanomaterials with outstanding photothermal (PT)/photodynamic (PD) property that could effectively suppress human gastric cancer and vo without obvious side effects. We revealed that CuS-NiS induced reactive oxygen species (ROS) generation, leading to apoptosis through Bcl-2/Bax pathway of human gastric cancer cells under 808 nm near-infrared (NIR) irradiation. Read More

Cureus 2020 Apr 10;12(4):e7617. Epub 2020 Apr 10.

Internal Medicine, Shaukat Khanum Memorial Hospital & Research Centre, Peshawar, PAK.

Metastatic disease is one of the few rare causes which can present with clinical and radiological features of acute appendicitis. In this article, we present a case of a 33-years-old man with known primary gastric malignancy undergoing adjuvant treatment, who presented with clinical peritonitis. Imaging findings revealed acute appendicitis and a sealed-off appendiceal perforation. Read More

Gastric Cancer 2020 May 7. Epub 2020 May 7.

Foundation for Detection of Early Gastric Carcinoma, 2-6-12 Nihombashikayabacho Chuo Ward, Tokyo, 103-0025, Japan.

Background: Helicobacter pylori (H. pylori) eradication is required to reduce incidence related to gastric cancer. Recently, it was found that even after the successful eradication of H. Read More

J Clin Med Res 2020 Apr 30;12(4):269-271. Epub 2020 Mar 30.

West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV 24901, USA.

The potential for splenic injury from esophagogastroduodenoscopy (EGD) is exceptionally low. To our knowledge, less than five cases have been reported in literature. Though still uncommon, splenic rupture due to diagnostic or therapeutic procedures is more frequently described following colonoscopy and endoscopic retrograde cholangiopancreatography. Read More

J Cancer Res Ther 2020 Jan-Mar;16(1):60-65

Department of Occupational Health and Industrial Medicine, Public Health and Community Medicine, Mansoura Faculty of Medicine, Mansoura University, Mansoura University, Mansoura, Egypt.

Objective: The objective of this study is to review the multidetector computed tomography (MDCT) findings of synchronous lymphoma and other solid malignancies.

Patients And Methods: This retrospective study included 18 patients confirmed with diagnosis of lymphoma and other solid malignancies. They were 8 women and 10 men (mean age, 62. Read More

Heliyon 2020 Apr 3;6(4):e03707. Epub 2020 Apr 3.

PET Center, Huashan Hospital of Fudan University, Shanghai, 200235, PR China.

Aim: Dermatomyositis (DM) is an inflammatory myopathy in adults that is strongly associated with malignancy. The aim of this study was to evaluate whether whole-body F-FDG PET/CT imaging can offer a standard option searching for underlying malignancy in DM patients.

Methods: Seventy-five patients diagnosed with DM were referred to our department for whole-body F-FDG PET/CT to determine whether the patients suffered from malignant tumor. Read More

Clin Endosc 2020 Mar 30;53(2):142-166. Epub 2020 Mar 30.

Department of Gastroenterology, Korea University Anam Hospital, Seoul, Korea.

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a standard treatment for early gastrointestinal cancers without regional lymph node metastasis. High-definition white light endoscopy, chromoendoscopy, and image-enhanced endoscopy such as narrow band imaging are performed to assess the edge and depth of early gastrointestinal cancers for delineation of resection boundaries and prediction of the possibility of lymph node metastasis before the decision of endoscopic resection. Endoscopic mucosal resection and/or endoscopic submucosal dissection can be performed to remove early gastrointestinal cancers completely by en bloc fashion. Read More

Anticancer Res 2020 Apr;40(4):2225-2229

Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.

Background: Primary hepatic carcinosarcoma is a rare subtype of liver malignancy, with only a small number of cases described in the English literature.

Case Report: We report the case of a 72-year-old man with a history of hepatitis C, who presented with complaints of abdominal pain. The patient's alpha fetoprotein (AFP) level was highly elevated at 7,406 ng/ml. Read More

Int J Neurosci 2020 Mar 23:1-6. Epub 2020 Mar 23.

Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.

Non-traumatic spontaneous acute epidural hematoma (EDH) happening to chronic subdural hematoma (SDH) caused by dural metastases is a rare entity. Pathogenesis can be derived from infection, coagulopathy, and inflammation. Malignant tumors metastasize to dura mater is one of the most infrequent causes. Read More

BMC Med Genet 2020 03 14;21(1):52. Epub 2020 Mar 14.

Section of General Surgery and Gastrointestinal Surgery, Department of Surgery I, Faculdade de Medicina do ABC, Avenida Lauro Gomes, 2000, Santo André/São Paulo, CEP 09060-870, Brazil.

Background: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis characterized by benign growth of the hair follicles, the presence of pulmonary cysts, spontaneous pneumothorax, and bilateral renal tumors that are usually hybrid oncocytic or multifocal chromophobe renal cell carcinoma. The diagnosis is confirmed by the presence of a pathogenic variant in the tumor suppressor folliculin (FLCN) gene mapped at 17p11.2. Read More

Am J Surg 2020 05 25;219(5):795-799. Epub 2020 Feb 25.

Division of Surgical Oncology, Oregon Health & Science University, USA. Electronic address:

Introduction: Neuroendocrine tumors (NETs) metastatic to the ovary are traditionally considered rare, but data are lacking. This study seeks to better characterize the prevalence and outcomes of patients with neuroendocrine ovarian metastases (NOM).

Methods: Women with well-differentiated lung and gastroenteropancreatic NETs 2007-2017 were identified by medical record query. Read More

DNA Cell Biol 2020 May 25;39(5):900-908. Epub 2020 Feb 25.

National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, China.

Reliable animal models are required for understanding the molecular events of gastric tumor growth and metastasis. Tracing techniques based on iRFP720 may optimize the noninvasive monitoring of tumors . The present study established a human gastric adenocarcinoma cell line BGC823-iRFP720-GFP (abbreviated as BGC823-iRFP) that stably expressed iRFP720 and green fluorescent protein (GFP) by transposon system. Read More

Cancer Biomark 2020 ;28(1):9-20

Department of Hepatobiliary Surgery, Enze Hospital, Wenzhou Medical University, Taizhou, Zhejiang, China.

Background: Recently, hepatocellular carcinoma (HCC) has been ranked as the second leading cause of cancer-associated death. However, the underlying molecular mechanisms of HCC progression remain unclear. Vesicular overexpressed in cancer pro-survival protein 1 (VOPP1) could be upregulated in a quantity of human cancers, including squamous cell carcinoma (SCC), gastric cancer, and glioblastoma. Read More

Mol Imaging Radionucl Ther 2020 Feb;29(1):25-32

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey

Objectives: The aim of this study was to evaluate F-fluoro-2-deoxy-glucose (FDG) uptake patterns in primary tumors and metastatic lesions, and also to assess the diagnostic contribution of positron emission tomography/computed tomography (PET/CT) in the initial staging of gastric cancer (GC).

Methods: The total number of 341 patients with GC were included in this study. All F-FDG PET/CT imagings were performed for initial staging. Read More

Spine Surg Relat Res 2020 1;4(1):64-68. Epub 2019 Nov 1.

Division of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.

Introduction: Leptomeningeal metastasis (LM) is known to demonstrate a very poor prognosis. The purpose of this study was to evaluate the prognostic factors in LM cases diagnosed by spinal magnetic resonance imaging (MRI).

Methods: We retrospectively analyzed 19 patients with LM detected by spinal MRI between 2010 and 2017. Read More

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(2):178-188

Department of Gastroenterology, Sendai City Medical Center.

We report the rare case of a 69-year-old man who underwent resection of a mixed adenoneuroendocrine carcinoma (MANEC) of the distal bile duct and a carcinoma in situ in the perihilar bile duct. The patient was admitted to our hospital for obstructive jaundice. Imaging studies revealed a mass in the distal bile duct, and an abnormal epithelium was detected in the perihilar bile duct using peroral cholangioscopy. Read More

Medicine (Baltimore) 2020 Jan;99(3):e18812

Breast Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, PR China.

Rationale: Breast cancer is the most commonly diagnosed malignancies in females. The most common sites of metastasis are bone, lung, liver, and brain. Gastrointestinal and adrenal gland metastasis from breast cancer are rare. Read More

J Nucl Med 2020 Jul 10;61(7):1072-1078. Epub 2020 Jan 10.

Department of Chemistry, University of Zurich, Zurich, Switzerland

Methods that provide rapid access to radiolabeled antibodies are vital in the development of diagnostic and radiotherapeutic agents for PET or radioimmunotherapy. The human hepatocyte growth factor receptor (c-MET) signaling pathway is dysregulated in several malignancies, including gastric cancer, and is an important biomarker in drug discovery. Here, we used a photoradiochemical approach to produce Zr-radiolabeled onartuzumab (a monovalent, antihuman c-MET antibody), starting directly from the fully formulated drug (MetMAb). Read More

Case Rep Gastroenterol 2019 Sep-Dec;13(3):532-538. Epub 2019 Dec 12.

Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.

While linked color imaging (LCI) may allow flat early gastric cancer to be detected early, the endoscopic and pathological features of lesions detected by LCI remain poorly described. Screening esophagogastroduodenoscopy performed on a 68-year-old woman revealed a yellowish, flat lesion shown to be reddish in its central area, located in the anterior wall of the gastric lower body on white light imaging (WLI). On LCI, the lesion was highlighted as an orangish, flat lesion shown to be purple-colored in its central area, surrounded by lavender-colored tissue. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2019 Jul;48(5):504-510

Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To assess the application of probe-based confocal laser endomicroscopy (pCLE) in diagnosis of gastric carcinoma and precancerous lesions.

Methods: Patients underwent pCLE in the First Affiliated Hospital of Zhejiang University School of Medicine during December 2013 and November 2014 and in the First Affiliated Hospital of Zhejiang Chinese Medical University during January 2014 and December 2017 were enrolled. The consistency between pCLE diagnosis and pathological diagnosis of gastric lesions, including atrophic gastritis, gastric intestinal metaplasia, low-grade intraepithelial neoplasia and high-grade intraepithelial neoplasia (including gastric carcinoma) was analyzed. Read More

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Department of Laboratories, College of Medicine & Philippine General Hospital, University of the Philippines Manila, Manila, Metro Manila, Philippines.

A 53-year-old man presented with a 3-month history of progressive, non-productive cough followed by occasional swelling of the face and upper extremities. Physical examination on admission revealed prominent superficial vessels at the neck and upper extremity swelling. Bronchoscopy revealed the superior segment of the right lower lobe was narrow but without visible mass; cell block and biopsy done revealed signet-ring cell carcinoma with an immunohistochemistry pattern favouring the primary site of malignancy as either gastric or of the pancreaticobiliary tree. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Dec;22(12):1196-1204

The Second Department of General Surgery, Baoding First Central Hospital, Hebei Baoding 071000, China.

To systematically evaluate the diagnostic value of optical imaging combined with indocyanine green (ICG)-guided sentinel lymph node (SLN) biopsy in gastric cancer, and to identify potential factors that would influence diagnostic accuracy. Study was carried out by searching the electronic database of PubMed, Embase, Medline, Web of Science, and the Cochrane Library with keywords as "gastric/stomach" and "cancer/carcinoma/tumor/tumour/adenocarcinoma/neoplasm" and "sentinel lymph node" and "near-infrared/NIR or fluorescent imaging" and "indocyanine green/ICG" . Literature inclusion criteria: (1) gastric cancer clinical stage was cT0-3; (2) clinical stage determined by at least 2 kinds of imaging modalities; (3) optical imaging (near-infrared or fluorescence imaging) combined with ICG-guided SLN biopsy; (4) prospective study to predict lymph node metastasis; (5) intraoperative or postoperative pathology for all lymph nodes removed; (6) patients number in the literature >10 cases. Read More

Front Microbiol 2019 6;10:2820. Epub 2019 Dec 6.

French National Reference Center for Campylobacters and Helicobacters, Bordeaux, France.

The present study describes three putative novel species received at the French National Reference Center for Campylobacters & Helicobacters (CNRCH). The CNRCH 2005/566H strain was isolated in 2005 from the feces of a patient with a hepatocellular carcinoma and gastroenteritis. Strain 48519 was isolated in 2017 from the blood of a male patient suffering from a bacteremia. Read More

BMJ Case Rep 2019 Dec 15;12(12). Epub 2019 Dec 15.

Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Acute gastrointestinal (GI) immune-related adverse events (irAE) are commonly reported by patients with cancer undergoing treatment with immune checkpoint inhibitors (CPI); however chronic irAEs are rare. We present a case of a 71-year-old woman with metastatic gastro-oesophageal junction (GOJ) adenocarcinoma who developed delayed-onset chronic intestinal pseudo-obstruction (CIPO) while receiving second-line pembrolizumab. Repeated CT scans of the abdomen/pelvis found no small bowel obstruction, and evaluations for bowel inflammation, infection and paraneoplastic syndrome were negative. Read More

J Int Med Res 2019 Dec 16:300060519892417. Epub 2019 Dec 16.

Department of Gastrointestinal Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Few cases of portal vein thrombosis secondary to gastric cancer surgery have been reported. Here we report the diagnosis and management of two such cases. Case 1: Gastric carcinoma with acute hematemesis was detected by endoscopy in the gastric body of a 48-year-old woman. Read More

Radiol Case Rep 2020 Feb 27;15(2):141-143. Epub 2019 Nov 27.

Department of Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.

Hepatocellular adenomas (HCAs) are benign lesions of the liver which can rarely undergo malignant transformation. We report a 26-year-old woman with no underlying liver disease found to have an incidental liver lesion on noncontrast CT during workup for gastric reflux. Follow up MRI revealed a 10 cm gadoxetate-retaining lesion within the right hepatic lobe with imaging features suggestive of HCA vs focal nodular hyperplasia . Read More

Pharmaceutics 2019 Dec 6;11(12). Epub 2019 Dec 6.

IRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.

One of the goals of the pharmaceutical sciences is the amelioration of targeted drug delivery. In this context, nanocarrier-dependent transportation represents an ideal method for confronting a broad range of human disorders. In this study, we investigated the possibility of improving the selective release of the anti-cancer drug paclitaxel (PTX) in the gastro-intestinal tract by encapsulating it into the biodegradable nanoparticles made by FDA-approved poly(lactic--glycolic acid) (PLGA) and coated with polyethylene glycol to improve their stability (PLGA-PEG-NPs). Read More

BMJ Case Rep 2019 Dec 2;12(12). Epub 2019 Dec 2.

Medicine I, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal.

Emphysematous gastritis is a rare disease characterised by air in the wall of the stomach due to gas-forming microorganisms. This is a highly lethal entity for which only prompt diagnosis and treatment can avoid mortality. Different factors have been described that disrupt the integrity of the mucosa such as corrosive ingestion, alcohol abuse, recent abdominal surgery or cancer. Read More

Br J Radiol 2020 Feb 3;93(1106):20190790. Epub 2019 Dec 3.

Department of Pathology, Affiliated Hospital of Jiangnan University, The Fourth People's Hospital of Wuxi City, Jiangsu Province, 214062, China.

Objective: To assess metastatic involvement of perigastric lymph nodes (PLN) in patients with T1 gastric cancer by using CT perfusion imaging (CTPI).

Methods: A total of 82 annotated PLN of 33 patients with T1 gastric cancer confirmed by endoscopic ultrasonography underwent CTPI and portal phase CT scan before operation. The scan data were post-processed to acquire perfusion maps and calculate perfusion parameters including blood flow (BF) and permeability surface (PS). Read More

Cancers (Basel) 2019 Nov 13;11(11). Epub 2019 Nov 13.

KU Leuven, Campus Gasthuisberg, Faculty of Medicine, 3000 Leuven, Belgium.

Cancer remains a major cause of death globally. Given its relapsing and fatal features, curing cancer seems to be something hardly possible for the majority of patients. In view of the development in cancer therapies, this article summarizes currently available cancer therapeutics and cure potential by cancer type and stage at diagnosis, based on literature and database reviews. Read More

Medicine (Baltimore) 2019 Nov;98(47):e18151

Department of Gastroenterology, Xiangcheng People's Hospital, Suzhou, China.

Rationale: Total pancreatectomy (TP) is performed in cases of multifocal and large invasive tumors of the pancreas, and is associated with high rates of mortality and morbidity. Previously, the limitations and unsatisfactory effect of this surgery rendered it rarely performed; however, with improvements in surgical techniques and blood sugar management, TP is now more frequently performed. TP has a similar long-term survival rate as that for pancreatoduodenectomy (PD). Read More

Gastroenterology 2020 02 15;158(3):485-487. Epub 2019 Nov 15.

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Digestive Function: Basel, Laboratory and Clinic for Motility Disorders and Functional GI diseases, Center for integrative Gastroenterology, Klinik Arlesheim, Arlesheim, Switzerland. Electronic address:

Asia Pac J Clin Oncol 2020 Feb 17;16(1):23-27. Epub 2019 Nov 17.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

Aim: The survival benefit of using a non-cross resistant second-line chemotherapy in the third-line setting in metastatic gastroesophageal cancer is unproven. We evaluated the utility of third-line chemotherapy in patients treated at a single institution.

Methods: Between 2010 and 2014, efficacy and toxicity data of patients who received three or more lines of systemic therapies for metastatic gastroesophageal adenocarcinoma at the National Cancer Centre Singapore was retrospectively analyzed. Read More

Presse Med 2019 Oct 14;48(10):1178-1180. Epub 2019 Nov 14.

University of Tunis el Manar, La Rabta University Hospital of Tunis, Department of Gastro-enetrology A, Tunis, Tunisia.

Gastroenterology 2020 02 12;158(3):760-769. Epub 2019 Nov 12.

Amsterdam University Medical Center, Amsterdam, The Netherlands.

Description: The purpose of this best practice advice article is to describe the role of Barrett's endoscopic therapy (BET) in patients with Barrett's esophagus (BE) with dysplasia and/or early cancer and appropriate follow-up of these patients.

Methods: The best practice advice provided in this document is based on evidence and relevant publications reviewed by the committee. BEST PRACTICE ADVICE 1: In BE patients with confirmed low-grade dysplasia, a repeat examination with high-definition white-light endoscopy should be performed within 3-6 months to rule out the presence of a visible lesion, which should prompt endoscopic resection. Read More