382,623 results match your criteria Gastric Carcinoma Imaging


Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs., Lyngby, Denmark.

Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric devices in micrometer size (microcontainers) were tested here for this purpose. Read More

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December 2018
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Predictor of Slower Gastric Emptying in Gastroesophageal Reflux Disease-Survey of An Asian-Pacific Cohort.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Asian populations have relatively lower prevalence of gastroesophageal reflux disease and tend to exhibit symptoms of prolonged gastric retention. However, it remains unknown if slower gastric empting influences its features in Asian countries.

Aim: We prospectively assessed the potential implications of slower gastric emptying in an Asian-Pacific cohort of gastroesophageal reflux disease by a hospital-based survey. Read More

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December 2018

How I Do it: Flexible 3D endoscope for Endoscopic Submucosal Dissection.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Division of Upper GI and Metabolic Surgery, Department of Surgery, Institute of Digestive Disease.

Endoscopic submucosal dissection (ESD) is technically challenging due to lack of depth perception. This report investigated effect of 3D endoscope for ESD and translate the technique from bench to clinical. In preclinical porcine experiment, the performance of ESD using 3D endoscope was compared between experienced and novice endoscopist. Read More

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December 2018
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Serum Alkaline Phosphatase Predicts Poor Disease-Free Survival in Patients Receiving Radical Gastrectomy.

Med Sci Monit 2018 Dec 14;24:9073-9080. Epub 2018 Dec 14.

Department of General Surgery, Chinese People's Liberation Army 309th Hospital, Beijing, China (mainland).

BACKGROUND Serum alkaline phosphatase (ALP) has been proved to be a negative prognostic factor for several malignancies, but its clinical significance in gastric cancer (GC) patients has not been sufficiently studied. In the present retrospective study, we investigated the effect of serum ALP on disease-free survival (DFS) after radical gastrectomy. MATERIAL AND METHODS We included 491 GC patients receiving radical gastrectomy at the Chinese People's Liberation Army 309th Hospital. Read More

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December 2018
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Alcohol and gastrointestinal cancers.

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

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December 2018

[A case of magnetic pharyngeal foreign body in children].

Authors:
X R Zhang Q Li

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1432-1433

Ingestion of magnetic foreign bodies is an increasing problem in the pediatric emergency in recent years.The majority of these injuries are ingestions involving the gastrointestinal tract, stomach, esophagus etc.Ingestion of multiple magnets has a high risk of bowel injury such as perforation or fistula. Read More

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September 2018

Effect of lncRNA BNC2-AS1 on the Proliferation, Migration and Invasion of Gastric Cancer Cells.

Clin Lab 2018 Oct;64(11)

Background: Gastric cancer is one of the most common cancers and is the second leading cause of cancer mortality worldwide. The present study aimed to investigate the potential biological effect of long non-coding RNA (lncRNA) BNC2-AS1 on the proliferation, migration, and invasion of cervical cancer cells. Methods: BNC2-AS1 small interfering RNA (siRNA) was transfected into SGC7901 and BGC823 gastric cancer cell lines, with negative siRNA serving as a control. Read More

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October 2018
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Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer.

Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.

Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More

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December 2018

Put The Blame On Gastric Bypass.

Authors:
Baris D Yildiz

Liver Transpl 2018 Dec 14. Epub 2018 Dec 14.

Ankara Numune Teaching Hospital General Surgery, Sihhiye, Ankara, Turkey.

We read with great interest the article titled "Impact of prior bariatric surgery on perioperative liver transplant outcomes" by Idriss et al (1). The authors gave a unique perspective to bariatric surgery and its relation to liver transplantation (LT). Although Roux and Y gastric bypass (RYGB) used to be considered as the gold standard (2) bariatric surgery procedure; since 2014 more than 50% of all bariatric procedures are sleeve gastrectomies (SG) (3). Read More

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December 2018

Successful Anti-reflux of Post-esophagectomy Using Endoscopic Suturing with Overstitch.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 210000.

The reflux of gastric contents into the esophagus is a common complication post-esophagectomy. Endoscopic suturing technique is becoming a useful treatment in gastrointestinal tract. This system takes advantage of robust tissue approximation by use of a suturing needle, equal to that of surgery. Read More

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December 2018

Artificial intelligence and upper gastrointestinal endoscopy: current status and future perspective.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Graduate School of Informatics, Nagoya University, Nagoya, Japan.

With recent breakthroughs in artificial intelligence, computer-aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Read More

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December 2018

Impact of genetic variation on pravastatin systemic exposure in pediatric hypercholesterolemia.

Clin Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

This study investigated the impact of SLCO1B1 genotype on pravastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-20 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n=15; 521CC, n=2) and wild type controls (521TT, n=15) completed a single oral dose pharmacokinetic study. Read More

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December 2018

Single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy for esophageal replacement.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatric Surgery, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction: We present a novel approach to single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy in a child with long-segment corrosive esophageal stricture (CES).

Materials And Surgical Technique: A 2.5-year-old boy with a history of caustic ingestion underwent periodic esophageal dilatations at 3-week intervals, four sessions of topical mitomycin C application, and a strict antacid/H antagonist therapy for 8 months. Read More

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December 2018

Impact of modified FOLFOX-6 for patients with gastric cancer and a gastrointestinal obstruction.

Asia Pac J Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine II, Osaka Medical College, Takatsuki, Osaka, Japan.

Aim: Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX-6 for gastric cancer patients with a gastrointestinal obstruction. Read More

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December 2018

Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells.

Cancer Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.

Recently, there has been an increased attention to circulating tumor cells (CTCs) analysis, also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. CTCs are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Read More

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December 2018

Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry.

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

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January 2019

Clinical investigation of esophageal injury from cryoballoon ablation of persistent atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 14. Epub 2018 Dec 14.

Heart center, Japan Red Cross Yokohama City Bay Hospital, Yokohama City, Japan.

Background: The cryoballoon (CB) can be utilized for extra pulmonary vein (PV) ablation such as for a left atrial (LA) posterior wall (LAPW) isolation. However, scrutiny of the esophageal injuries during the LAPW isolation has never been performed. We sought to thoroughly investigate the esophageal lesions (ELs) and gastric hypomotility (GH) caused by an LAPW isolation using a CB. Read More

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December 2018

Molecular diagnosis of Helicobacter pylori infection in gastric biopsies: Evaluation of the Amplidiag H. pylori + ClariR assay.

Helicobacter 2018 Dec 12:e12560. Epub 2018 Dec 12.

Bacteriology, Cochin Hospital, University of Paris-Descartes, Institut Pasteur, Paris, France.

Background: Adapted treatments for Helicobacter pylori infection, guided by determining antimicrobial resistance, are associated with high eradication rates. We evaluated the performance of the Amplidiag H. pylori + ClariR PCR assay (Amplidiag ) for detecting H. Read More

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December 2018

Comparative proteomics of Helicobacter pylori strains reveals geographical features rather than genomic variations.

Genes Cells 2018 Dec 12. Epub 2018 Dec 12.

Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku Kyoto, Japan, 606-8501.

Helicobacter pylori, a pathogen of various gastric diseases, has many genome sequence variants. Thus, the pathogenesis and infection mechanisms of the H. pylori-driven gastric diseases have not been elucidated. Read More

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December 2018

Gastric hemorrhage due to splenomegaly following repair of a type A aortic dissection.

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

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December 2018

TIGD1, a gene of unknown function, involves cell-cycle progression and correlates with poor prognosis in human cancer.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China.

Background: Trigger transposable element-derived 1 (TIGD1), a human species-specific gene, was identified as a cell cycle-related differentially expressed gene during the formation of liver cancer. As far as we know, there are no reports about the function of TIGD1. This study aimed to explore the expression of TIGD1 in human cancers and establish whether elevated TIGD1 can be used as a prognostic cancer biomarker and its potential role in cancer. Read More

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December 2018

Alkaline, protein, low-fat and low-acid diet in laryngopharyngeal reflux disease: Our experience on 65 patients.

Clin Otolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.

The respect of diet and lifestyle modifications could be associated with better improvement of laryngopharyngeal symptoms, perceptual dysphonia, and acoustic measurements. The potential positive impact of alkaline, protein, low-fat, low-acid diet could be explained by many physiological effects on esophageal sphincter tonicity, acid and pepsin productions, and gastric emptying time. Future controlled prospective studies are needed to confirm the potential key role of alkaline, protein, low-fat, low-acid diet and lifestyle modifications in the clinical improvement of patients with suspected LPR disease. Read More

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December 2018

High-energy nutrition in paediatric cardiac critical care patients: a randomized controlled trial.

Nurs Crit Care 2018 Dec 9. Epub 2018 Dec 9.

Nursing Department, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

Background: Previous studies have shown that feeding a high-energy formula (HF) to infants after cardiac surgery increases energy intake, with fewer side effects on cardiopulmonary function. However, impacts on weight gain and gastrointestinal function remain unclear.

Aims And Objectives: To determine the impact of HF compared with standard formula on weight gain and gastrointestinal tolerance in postoperative infants with congenital heart disease. Read More

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December 2018

A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):116. Epub 2018 Dec 14.

Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, 130012, China.

Background: Nowadays, because of the huge economic burden on society causing by obesity and diabetes, they turn into the most serious public health challenges in the world. To reveal the close and complex relationships between diabetes, obesity and other diseases, search the effective treatment for them, a novel model named as representative latent Dirichlet allocation (RLDA) topic model is presented.

Results: RLDA was applied to a corpus of more than 337,000 literatures of diabetes and obesity which were published from 2007 to 2016. Read More

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December 2018

Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1.

J Exp Clin Cancer Res 2018 Dec 14;37(1):317. Epub 2018 Dec 14.

The Research Center for Medical Genomics, School of Life Sciences, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, 110122, People's Republic of China.

Background: Gastric cancer is one of the most common malignant tumors. Cyclin G2 has been shown to be associated with the development of multiple types of tumors, but its underlying mechanisms in gastric tumors is not well-understood. The aim of this study is to investigate the role and the underlying mechanisms of cyclin G2 on Wnt/β-catenin signaling in gastric cancer. Read More

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December 2018

Development and evaluation of a broadly reactive reverse transcription recombinase polymerase amplification assay for rapid detection of murine norovirus.

BMC Vet Res 2018 Dec 14;14(1):399. Epub 2018 Dec 14.

Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.

Background: Murine norovirus (MNV) is recognized as the most prevalent viral pathogen in captive mouse colonies. The rapid detection assay for MNV would be a useful tool for monitoring and preventing MNV infection. A recombinase polymerase amplification (RPA) assay was established in this study to provide a solution for rapid and sensitive detection of MNV. Read More

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December 2018

[Critically ill patient enteral nutrition in the 21st century].

Nutr Hosp 2018 Apr 3;35(Spec no2):27-33. Epub 2018 Apr 3.

.

In order to make estimations on the evolution and near future of enteral nutrition in critically ill adult patients, we have revised the current clinical practices based on the latest guidelines for the provision and assessment of enteral nutrition support therapy. Once revised the suggested guideline recommendations we proceed to discuss the major recently published studies concerning these guidelines. Finally, we commented on several uncertainty areas highlighting priorities for clinical research in the near future. Read More

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Acute ST segment elevation secondary to acute gastric distention.

J Cardiol Cases 2013 Sep 11;8(3):108-112. Epub 2013 Jul 11.

Division of Cardiology, Section of Electrophysiology, University of Nebraska Medical Center, Omaha, NE, USA.

An adolescent male trauma patient developed new asymptomatic ST segment elevations that mimicked a myocardial infarction on infero-lateral telemetry leads on hospital day #8, following burn excision and skin grafting. This was confirmed on 12 lead electrocardiogram. Laboratory test results indicated normal potassium. Read More

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September 2013

Subtherapeutic anticoagulation with dabigatran following Roux-en-Y gastric bypass surgery.

J Cardiol Cases 2013 Jul 29;8(1):e49-e50. Epub 2013 Apr 29.

Division of Hematology and Cellular Therapy, West Penn Allegheny Health System, Pittsburgh, PA, USA.

We report a 66-year-old male with a history of Roux-en-Y gastric bypass surgery who began dabigatran for new onset atrial fibrillation. After 5 weeks of therapy, his transesophageal echocardiogram prior to electrocardioversion showed severe spontaneous echo contrast. Cardioversion was postponed and anticoagulant therapy was continued. Read More

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A case of Takotsubo cardiomyopathy that was confirmed by cardiac catheterization at all three times of onset.

J Cardiol Cases 2015 Nov 15;12(5):152-155. Epub 2015 Jul 15.

Department of Cardiology, Cardiovascular Center, Toranomon Hospital, Tokyo, Japan.

Takotsubo cardiomyopathy (TTC) is a cardiomyopathy associated with emotional and physiological stress which can be recurrent. We report a case of recurrent TTC (total 3 times) induced by emotional stress, which was diagnosed accurately by coronary angiography (CAG) and left ventriculography (LVG). A 77-year-old female was referred to our institute because of stomach ache, nausea, dizziness, and vomiting. Read More

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November 2015

Long and wrong way: Unintended pericardial catheter insertion through stomach.

J Cardiol Cases 2014 Aug 19;10(2):66-68. Epub 2014 Jun 19.

Department of Cardiovascular Surgery, Hacettepe University School of Medicine, Ankara, Turkey.

Complications of percutaneous pericardial catheter insertion for pericardial effusion are rare. We describe a rare complication of percutaneous pericardial catheter insertion that penetrated the stomach and diaphragm before getting into the pericardial sac in a patient with lymphoma. The misplaced catheter was extracted surgically and subxiphoid pericardial tube insertion with pleural pericardial window was performed. Read More

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Use of the Physiologically Based Extraction Test for the Assessment of Bioaccessibility of Toxic Metals in Vegetables Grown on Contaminated Soils.

J Health Pollut 2016 Jun 30;6(10):74-83. Epub 2016 Jun 30.

Background: An important concern for human health is the uptake of toxic metals by vegetables from soils and their consumption by humans.

Objectives: To assess the oral bioaccessibility of metals in vegetables (spinach, pumpkin, celosia, okro leaves and waterleaf) grown on contaminated soils collected from five different sites in Lagos, Nigeria.

Methods: The soil and vegetables were acid digested and the total metal concentrations (copper (Cu), cadmium (Cd), chromium (Cr), lead (Pb) and zinc (Zn)) were determined using a flame atomic absorption spectrophotometer. Read More

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Surgery for Locally Advanced GIT Cancers Has Potentially Good Postoperative Outcomes in a Tertiary Hospital.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

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December 2018

Early Hereditary Diffuse Gastric Cancer (eHDGC) is Characterized by Subtle Genomic Instability and Active DNA Damage Response.

Pathol Oncol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Biomedical Science and Biochemistry, Research School of Biology, ANU College of Medicine, Biology and Environment, Australian National University, P.O. Box: 2601, Canberra, Australia.

Diffuse gastric cancer (DGC) is one of the two primary types of stomach cancer. Carriers of germline mutations in the gene encoding E-cadherin are predisposed to DGC. The primary aim of the present study was to determine if genomic instability is an early event in DGC and how it may lead to disease progression. Read More

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December 2018
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Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report.

Surg Case Rep 2018 Dec 13;4(1):144. Epub 2018 Dec 13.

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Gastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.

Case Presentation: An 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Read More

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December 2018

Rare anatomic variation of the hepatic arterial blood supply: case report and literature review.

Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.

Department of General and Minimally Invasive Surgery, Centre Hospitalier de Luxembourg, 4, rue Ernest Barblé, 1210, Luxembourg City, Luxembourg.

Purpose: Our aim is to present a rare case of anatomic variation of the arterial blood supply to the liver because preoperative knowledge of hepatic vascular variations is mandatory in hepatic surgery and liver transplantation.

Methods: We present a case of unusual arterial blood supply to the liver, a right hepatic artery coming from the splenic artery, associated to a classical common hepatic artery and a left hepatic artery from the left gastric artery. Preoperative diagnosis was made using CT-scan and 3D reconstruction. Read More

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December 2018
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Low dosage of apatinib monotherapy as rescue treatment in advanced lung squamous cell carcinoma.

Cancer Chemother Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Respiratory and Critical Care, The First Affiliated Hospital of Soochow University, No.899, Pinghai Road, Suzhou, 215006, People's Republic of China.

Purpose: Platinum-based doublet chemotherapy and radiotherapy are the standard treatment option in advanced squamous cell carcinoma patients. However, few agents could be selected for subsequent post-second-line treatment. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, apatinib had been proved in advanced gastric cancer. Read More

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December 2018
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Post-traumatic pseudoaneurysms of the left gastric artery: A case report.

Trauma Case Rep 2019 Feb 5;19:1-6. Epub 2018 Dec 5.

Department of General Surgery, Division of Trauma Surgery, Eulji University Hostpital, Daejeon, Republic of Korea.

Post-traumatic pseudoaneurysm of the gastric artery is very rare. Prompt diagnosis and management are necessary because mortality is high due to massive intra-abdominal hemorrhage. A 79-year-old man complained of abdominal pain after slipping down 2 days prior to admission. Read More

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February 2019

Characterization of zolbetuximab in pancreatic cancer models.

Oncoimmunology 2019 10;8(1):e1523096. Epub 2018 Nov 10.

TRON - Translational Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

In healthy tissue, the tight junction protein Claudin 18.2 (CLDN18.2) is present only in the gastric mucosa. Read More

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November 2018

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies.

Oncoimmunology 2019 2;8(1):e1512458. Epub 2018 Nov 2.

German Cancer Consortium (DKTK), Heidelberg, Germany.

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. Read More

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November 2018

Upper Gastrointestinal Bleed Embolization with Onyx: The "Tattoo Effect".

J Clin Imaging Sci 2018 15;8:46. Epub 2018 Nov 15.

Division of Gastroenterology and Hepatology, University of Kentucky, College of Medicine, Lexington, Kentucky, USA.

Endoscopic intervention is well validated for the control of upper gastrointestinal bleeding (UGIB). In cases of refractory bleeding, transarterial embolization is a safe and effective alternative. Ethylene vinyl alcohol (EVOH) commonly known as Onyx is an inherently black liquid embolic approved for use in cerebrovascular arteriovenous malformations and is increasingly used as an embolic agent in multiple peripheral and visceral territories. Read More

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November 2018

Aggressive undifferentiated pleomorphic sarcoma of the stomach involving long-term survival: A case report and literature review.

Mol Clin Oncol 2018 Dec 5;9(6):661-665. Epub 2018 Oct 5.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan.

Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital. Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. Read More

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December 2018

Measurable Krukenberg tumor is preferably characterized as a non-target lesion in the clinical evaluation of gastric cancer therapeutics: A case report.

Mol Clin Oncol 2018 Dec 8;9(6):622-628. Epub 2018 Oct 8.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Metastatic cystic lesions may be considered as target lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. However, cystic lesions are considered as non-measurable according to RECIST 1. Read More

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December 2018

Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report.

Mol Clin Oncol 2018 Dec 5;9(6):607-612. Epub 2018 Oct 5.

Department of Oncology, Hainan Branch of PLA General Hospital, Sanya, Hainan 572000, P.R. China.

Gastric adenocarcinoma concurrent with metastatic neuroendocrine cancer (NEC) is rare. In the present case report, a 39-year-old male was first pathologically diagnosed by gastric endoscopy as having a highly differentiated adenocarcinoma. Next, positron emission tomography-computed tomography examination and bone marrow biopsy confirmed extensive metastasis. Read More

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December 2018

Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.

Biomed Rep 2018 Dec 18;9(6):511-516. Epub 2018 Oct 18.

Department of Physiology and Biochemistry, Princess Basma Teaching Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Previous studies have shown that progesterone could inhibit muscle contraction in various sites of the gastrointestinal tract. The underlying mechanisms responsible for these inhibitory effects of progesterone are not fully known. The aim of the current study was to investigate the effect of progesterone on the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway and muscle contraction in the stomach. Read More

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December 2018

MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer.

Oncol Lett 2018 Dec 27;16(6):7295-7301. Epub 2018 Sep 27.

Department of Pancreatic and Thyroidal Surgery, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning 110000, P.R. China.

Pancreatic cancer is an aggressive type of cancer with a poor prognosis, short survival rate and high mortality. Therefore, understanding the molecular mechanism underlying the aggressive growth of pancreatic cancer is of importance. An increasing number of studies suggest that numerous microRNAs (miRNAs/miRs) are associated with the tumorigenesis, progression and prognosis of tumors. Read More

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December 2018

High expression of class III β-tubulin in upper gastrointestinal cancer types.

Oncol Lett 2018 Dec 25;16(6):7139-7145. Epub 2018 Sep 25.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62. Read More

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December 2018
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Correlation of xeroderma pigmentosum complementation group F expression with gastric cancer and prognosis.

Oncol Lett 2018 Dec 28;16(6):6971-6976. Epub 2018 Sep 28.

Department of Anesthesia, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China.

Correlation of xeroderma pigmentosum complementation group F (XPF) expression with gastric cancer and prognosis was investigated. We randomly selected 76 gastric cancer patients who were admitted to the Second People's Hospital of Dezhou City and received treatment, and detected XPF expression in gastric cancer tissues (observation group) and normal gastric mucosa adjacent to tumor (control group) via immunohistochemistry. Correlation between XPF expression and clinicopathological indicators of gastric cancer was verified via single-factor Chi-square test. Read More

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December 2018