49,191 results match your criteria Gastric Carcinoma


Cost-effectiveness Analysis of Bariatric Surgery for Patients With Nonalcoholic Steatohepatitis Cirrhosis.

JAMA Netw Open 2019 Feb 1;2(2):e190047. Epub 2019 Feb 1.

Division of Digestive and Liver Diseases, Department of Medicine,Columbia University Medical Center, New York, New York.

Importance: Obesity is the most common risk factor for nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease that can lead to cirrhosis and hepatocellular carcinoma. Weight loss can be an effective treatment for obesity and may slow the progression of advanced liver disease.

Objective: To assess the cost-effectiveness of bariatric surgery in patients with NASH and compensated cirrhosis. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.0047DOI Listing
February 2019

A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series.

Ann Med Surg (Lond) 2019 Mar 30;39:10-15. Epub 2019 Jan 30.

Department of Surgery, Jichi Medical University, Tochigi, Japan.

Background And Objectives: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on prognosis of positive cytology were analyzed. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370578PMC

Strategy for treatment of stage IV human epidermal growth factor 2-positive gastric cancer: a case report.

J Med Case Rep 2019 Feb 22;13(1):42. Epub 2019 Feb 22.

Department of Surgery, Osaka Red Cross Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.

Background: The prognosis of stage IV gastric cancer and human epidermal growth factor 2 (HER2)-positive gastric cancer is poor, although new drugs and regimens have been developed. We report a case of a patient with stage IV HER2-positive gastric cancer treated successfully by conversion therapy and trastuzumab.

Case Presentation: The patient was a 73-year-old Japanese man diagnosed as L, type 3, circ, T4aNxCy1P1M1, stage IV (the Japanese classification of gastric carcinoma). Read More

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http://dx.doi.org/10.1186/s13256-019-2001-3DOI Listing
February 2019

KCNMA1 Expression is Downregulated in Colorectal Cancer via Epigenetic Mechanisms.

Cancers (Basel) 2019 Feb 19;11(2). Epub 2019 Feb 19.

Department of Medical and Surgical Sciences and Advanced Technology "G.F. Ingrassia", University of Catania, Via Santa Sofia 86, 95123 Catania, Italy.

is a gene located at 10q22 that encodes the pore-forming α-subunit of the large-conductance Ca-activated K⁺ channel. is down-regulated in gastric carcinoma tumors, through hypermethylation of its promoter. In the present study, we have evaluated the expression levels of both in a mouse model of Colorectal Cancer (CRC) and in human CRC samples. Read More

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http://dx.doi.org/10.3390/cancers11020245DOI Listing
February 2019
1 Read

Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis.

J Gastrointest Oncol 2019 Feb;10(1):85-94

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.

Background: Gastric squamous cell carcinoma (GSCC) and gastric adenosquamous carcinoma (GASC) comprise less than 2% of gastric cancers. The current knowledge about clinical presentation, treatment modalities and outcomes of GSCC and GASC is limited. The aim of this study is to characterize the clinicopathological features, treatment modalities, and outcomes of GSCC and GASC in comparison to gastric adenocarcinoma (GAC) in National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.21037/jgo.2018.10.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351299PMC
February 2019

lncRNA GHET1 knockdown suppresses breast cancer activity in vitro and in vivo.

Am J Transl Res 2019 15;11(1):31-44. Epub 2019 Jan 15.

Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

Long non-coding RNA gastric carcinoma high-expressed transcript 1 (lncRNA GHET1) is highly expressed in many tumors. The aim of the present study was to determine whether GHET1 inhibition decreases growth and metastasis of MCF-7 breast cancer cells by modulating epidermal growth factor receptor (EGFR) expression. In vitro, lncRNA GHET1 knockdown suppressed cell proliferation, migration, and invasion and enhanced cell apoptosis by maintaining MCF-7 cells in the G1 phase of the cell cycle. Read More

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January 2019

An investigation on the cytotoxicity and caspase-mediated apoptotic effect of biologically synthesized gold nanoparticles using on AGS gastric carcinoma cells.

Int J Nanomedicine 2019 5;14:951-962. Epub 2019 Feb 5.

Gastrointestinal Surgical Ward, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, China,

Background: Gastric cancer is the fourth most common cancer and second leading cause of cancer death worldwide. is used to treat nerve disorders, stiffness, rheumatism, ear ache, snake bite, and so on.

Methods: In this study, the reaction parameters were optimized to control the size of the nanoparticle, which was confirmed by transmission electron microscopy. Read More

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http://dx.doi.org/10.2147/IJN.S193064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368113PMC
February 2019

Activation of CD3 T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma.

Cancer Biol Ther 2019 Feb 20:1-11. Epub 2019 Feb 20.

a Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.

Most of gastric carcinoma (GC) is attributed to infection by Helicobacter pylori (H. pylori) but there is increasing evidence that the positive H. pylori status correlates with better prognosis in GC. Read More

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http://dx.doi.org/10.1080/15384047.2019.1579957DOI Listing
February 2019

Adenocarcinoma of oesophagus involving gastro-oesophageal junction following mini-gastric bypass/one anastomosis gastric bypass.

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Mini-gastric bypass/one anastomosis gastric bypass (MGB/OAGB) is an emerging weight loss surgical procedure. There are serious concerns not only regarding the symptomatic biliary reflux into the stomach and the oesophagus but also the increased risk of malignancy after MGB/OAGB. A 54-year-old male, with a body mass index (BMI) of 46. Read More

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http://dx.doi.org/10.4103/jmas.JMAS_320_18DOI Listing
February 2019

Laparoscopic gastrectomy for early gastric cancer and the risk factors of lymph node metastasis.

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Objective: Lymph node metastasis (LNM) is one of the important prognostic factors of early gastric cancer (EGC). Moreover, LNM is also important when choosing therapeutic intervention for EGC patients. The purpose of this study is to explore the risk factors of LNM in EGC and to discuss the corresponding treatment. Read More

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http://dx.doi.org/10.4103/jmas.JMAS_296_18DOI Listing
February 2019

Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma.

Cancer Sci 2019 Feb 18. Epub 2019 Feb 18.

Gastric Surgery Division, National Cancer Center Hospital, Tokyo.

Neural invasion is one of the malignant features contributing to locally advanced and/or metastatic disease progression in patients with pancreatic ductal adenocarcinoma (PDAC). Few studies exist about the distribution and state of nerve fibers in PDAC tissue and about their clinicopathological impacts. The aim of this study was to investigate the clinicopathological characteristics and prognostic value of intrapancreatic neural alterations in patients with PDAC. Read More

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http://dx.doi.org/10.1111/cas.13975DOI Listing
February 2019

Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.022DOI Listing
February 2019
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Subtraction of Epstein-Barr virus and microsatellite instability genotypes from the Lauren histotypes: combined molecular and histologic subtyping with clinicopathological and prognostic significance validated in a cohort of 1,248 cases.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Limited studies investigated clinicopathological and prognostic significance of histologic and molecular subgroups of gastric cancer concurrently. We retrospectively enrolled 1,248 patients with gastric cancer who received radical gastrectomy with lymphadenectomy and classified these cases into the Epstein-Barr virus (EBV)-associated and microsatellite instability (MSI)-associated subtypes by EBV-encoded small RNA in situ hybridization and immunohistochemical stains for DNA mismatch repair proteins, respectively. The remaining cases were categorized as the Lauren intestinal and diffuse/mixed subtypes. Read More

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http://dx.doi.org/10.1002/ijc.32215DOI Listing
February 2019
1 Read

Mediterranean diet adherence and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study.

Gastric Cancer 2019 Feb 15. Epub 2019 Feb 15.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Background: Mediterranean diet (MD) adherence has been associated with reduced risks of esophageal and gastric cancer (subtypes) in a limited number of studies. We prospectively investigated associations between MD adherence and risks of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) in a Dutch cohort.

Methods: Analyses were conducted using data from the 120852 participants of the Netherlands Cohort Study (NLCS), who were aged between 55 and 69 years at enrollment. Read More

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http://link.springer.com/10.1007/s10120-019-00927-x
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http://dx.doi.org/10.1007/s10120-019-00927-xDOI Listing
February 2019
3 Reads

Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
February 2019
1 Read

Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer.

Biomark Med 2019 Feb 15. Epub 2019 Feb 15.

Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430000, PR China.

Aim: To assess SLC6A6 expression in gastric cancer, its correlation with patients' clinicopathological features and survival, and the possible epigenetic regulation mechanism.

Methods: Expression profiles and methylation data were obtained from the Gene Expression Omnibus database and the Cancer Genome Atlas. The SLC6A6's protein level were obtained from the Human Protein Atlas. Read More

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http://dx.doi.org/10.2217/bmm-2018-0256DOI Listing
February 2019

[A Case of Resection of Advanced Pancreatic Adenosquamous Carcinoma in which Multidisciplinary Treatment Was Effective].

Gan To Kagaku Ryoho 2019 Jan;46(1):178-180

Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.

A 72-year-old man with general fatigue was referred, and CT and MRI revealed a pancreatic mass with necrosis that was suspected of invading the stomach, splenic artery, celiac artery, liver, and portal vein. Upper gastrointestinal endoscopy showed an extrinsic mass with ulcer formation in the posterior wall of the upper gastric corpus and irregular mucosa in the lower esophagus incidentally. Biopsy showed squamous cell carcinoma from both lesions, leading to the diagnosis of pancreatic adenosquamous carcinoma and early esophageal cancer. Read More

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January 2019
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[Curative Resection of Pancreatic Head Cancer with Liver Metastasis after GEM plus Nab-PTX Therapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):169-171

Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center.

A 63-year-old man was admitted to our hospital for examination and treatment of a pancreatic head tumor detected at a nearby hospital. After CT, EUS-FNA, and PET-CT, he was diagnosed with unresectable pancreatic cancer with liver metastasis. After 9 courses of gemcitabine and nab-paclitaxel therapy, the primary tumor was dramatically reduced in size and the liver metastasis had disappeared. Read More

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January 2019

[A Case of Breast Metastasis of Gastric Cancer after an Eight Year Latency Period].

Gan To Kagaku Ryoho 2019 Jan;46(1):154-156

Dept. of Surgery, Okayama Rosai Hospital.

A 66-year-old woman underwent distal gastrectomy because of gastric cancer(stage ⅠB)and received no adjuvant chemotherapy. Eight years after the operation, computed tomography showed a small nodule in the right breast. Mammography did not reveal any abnormalities. Read More

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January 2019

[A Case of Liver Recurrence of Choriocarcinoma and AFP-Producing Carcinoma of the Stomach Showing a Complete Histological Response after Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):151-153

Dept. of Surgery, Aomori City Hospital.

A 65-year-old man was hospitalized for gastric cancer. Abdominal computed tomography detected lower gastric cancer and invasion of the liver. Initial laboratory data showed high levels of serum AFP(2,688. Read More

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January 2019

[A Case of Gastric Small Cell Carcinoma with Rapid Regrowth after Surgery].

Gan To Kagaku Ryoho 2019 Jan;46(1):145-147

Dept. of Surgery, Tsuyama Chuo Hospital.

The patient was a 59-year-old man with type 2 advanced gastric cancer in the antrum. Abdominal computed tomography revealed the primary tumor with regional lymph node metastasis. Distal gastrectomy and D2 lymph node dissection were performed. Read More

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January 2019
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[A Case of Gastric Neuroendocrine Carcinoma with Bulky Lymph Node Metastases, Solitary Liver Metastasis, and Left Adrenal Metastasis Curatively Resected after Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):103-105

Dept. of Surgery, Osaka City Juso Hospital.

A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Read More

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January 2019
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[Gastric Neuroendocrine Carcinoma(NEC)Treated with CDDP plus CPT-11 Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):65-69

Dept. of Digestive Surgery, Saku Central Hospital Advanced Care Center.

A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Read More

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January 2019
6 Reads

A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach.

Virchows Arch 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Primary gastric squamous cell carcinoma (SCC) is a rare histological subtype of gastric cancer. Here, we report the first case of primary gastric verrucous carcinoma (VC), a well-differentiated variant of SCC. Gastroscopy revealed a papillary polypoid lesion at the posterior wall of the upper gastric body and isolated squamous epithelium at the greater curvature of the fornix in a 78-year-old woman. Read More

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http://link.springer.com/10.1007/s00428-019-02542-8
Publisher Site
http://dx.doi.org/10.1007/s00428-019-02542-8DOI Listing
February 2019
4 Reads

Cytoreductive surgery and heated intraperitoneal chemotherapy for peritoneal carcinomatosis from rare etiologies.

Am J Surg 2019 Jan 25. Epub 2019 Jan 25.

Department of Surgery and Oncology, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) are commonly used in the treatment of peritoneal carcinomatosis (PC) originating from colorectal, appendiceal and ovarian cancers. It is unclear what benefit CRS/HIPEC might have for PC from uncommon etiologies, therefore we sought to describe local practice patterns and evaluate overall survival (OS).

Methods: All patients who had CRS/HIPEC between 2000 and 2016 were identified using our institutional cancer database. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.01.011DOI Listing
January 2019
1 Read

Risk of lymph node metastasis in undifferentiated-type mucosal gastric carcinoma.

World J Surg Oncol 2019 Feb 13;17(1):32. Epub 2019 Feb 13.

Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Endoscopic resection (ER) has come to be recognized as a standard treatment for early gastric cancer (EGC). While its adoption is expanding, ER remains restricted to cases of EGC without lymph node metastasis for the treatment of local resection. On the other hand, histopathological analyses of surgically resected specimens of EGC have revealed the presence of lymph node (LN) metastasis in some cases of mucosal gastric cancer (MGC) and undifferentiated MGC (UD-MGC) is considered to have higher risk of nodal metastases than differentiated MGC (D-MGC). Read More

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http://dx.doi.org/10.1186/s12957-019-1571-2DOI Listing
February 2019

[Gastric signet ring cell carcinoma : New aspects for long-range prognosis].

Authors:
W Schröder C Bruns

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik für Allgemein‑, Viszeral- und Tumorchirurgie, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0850-3DOI Listing
February 2019

A case of human pancreatic eurytremiasis.

Abdom Radiol (NY) 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology and Laboratory Medicine, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.

This study provides the first comprehensive imaging report of human pancreatic eurytremiasis. A 43-year-old man with obstructive jaundice and a pancreatic tumor was referred for diagnosis and treatment. Serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were elevated. Read More

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http://dx.doi.org/10.1007/s00261-019-01925-4DOI Listing
February 2019

[Progress in roles and mechanisms of deacetylase SIRT7].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):13-26

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. Read More

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http://dx.doi.org/10.13345/j.cjb.180139DOI Listing
January 2019
1 Read

Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.

J Gastrointest Surg 2019 Feb 12. Epub 2019 Feb 12.

Section of Hepatobiliary and Pancreatic Surgery, Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Background: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease.

Materials And Methods: We maintain a prospective high volume gastrointestinal malignancy PDX program. Read More

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http://dx.doi.org/10.1007/s11605-019-04109-zDOI Listing
February 2019
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Identification of early genetic changes in well-differentiated intramucosal gastric carcinoma by target deep sequencing.

Gastric Cancer 2019 Feb 11. Epub 2019 Feb 11.

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Background And Aims: The recent advancement of next-generation sequencing (NGS) has enabled the identification of cancer-related somatic aberrations in advanced gastric cancer. However, these remain unclear in early gastric cancers, especially in intramucosal gastric cancers.

Patients And Methods: Thirty-one well-differentiated (tub1) intramucosal gastric cancers obtained by endoscopic submucosal dissection (ESD) from 29 patients were analyzed. Read More

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http://dx.doi.org/10.1007/s10120-019-00926-yDOI Listing
February 2019

Acute Anaemia: A Challenging Diagnosis.

Eur J Case Rep Intern Med 2018 27;5(9):000956. Epub 2018 Sep 27.

Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.

Acute anaemia is characterized by a reduction in the number of red blood cells, haemoglobin levels or haematocrit. By far the most common aetiology is haemorrhage, but in its absence other less frequent causes should be considered. The authors present the case of a 42-year-old man with a diagnosis of glucose-6-phosphate deficiency and progressing gastric signet ring cell carcinoma, who was admitted to the internal medicine department for symptomatic back pain control. Read More

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http://dx.doi.org/10.12890/2018_000956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346818PMC
September 2018
1 Read

Transhepatic forceps biopsy after PTCD for histological assessment of bile duct stenoses or occlusions.

Z Gastroenterol 2019 Feb 12;57(2):133-138. Epub 2019 Feb 12.

Institute of Radiology and Nuclear Medicine, Klinikum Nürnberg Nord, Nürnberg, Germany.

Purpose:  The goal of this study was to evaluate the experience of 11 years of wire-guided forceps biopsy via PTCD in patients with obstructive jaundice.

Materials And Methods:  In a retrospective approach, 56 biopsies in 51 patients were analyzed (22 female, 29 male). Data was collected from 2006 to 2016. Read More

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http://dx.doi.org/10.1055/a-0821-7060DOI Listing
February 2019
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[Antonio Benivieni (1443-1502), Physician of the Renaissance].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2018 Nov;26(6):502-504

The S. I. Georgievsky Medical Academy (Structural Department) of The Federal State Autonomous Educational Institution of Higher Education «The V. I. Vernadsky Crimea Federal University», 295051. Simferopol, Russia.

Antonio di Paolo Benivieni (1443-1502) is one of the greatest physicians of Renaissance unfairly forgotten at the present time. Benivieni, in his major work of all his life «De abditis nonnullis ac mirandis morborum et sanationum causis», presents not only description of pathologic alterations (including the first in history description of carcinoma of pyloric part of stomach, mesenterial occlusion, fibrinogenous pericarditis) discovered at dissection but he tries to analyze and compare pathologic anatomic and clinical data. The treatise itself is the first in history pathologic anatomic work. Read More

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http://dx.doi.org/10.32687/0869-866X-2018-26-6-502-504DOI Listing
November 2018

The impact of reducing alcohol consumption in Australia: an estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019
2 Reads

Expression and significance of EBV, ARID1A and PIK3CA in gastric carcinoma.

Mol Med Rep 2019 Mar 22;19(3):2125-2136. Epub 2019 Jan 22.

Department of Pathology, Central South University, Xiangya School of Medicine, Affiliated Haikou Hospital, Haikou, Hainan 570208, P.R. China.

AT‑rich interaction domain 1A (ARID1A) and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit α (PIK3CA) serve important roles in the formation and development of numerous malignancies including gastric cancer. Accumulating evidence has demonstrated that Epstein‑Barr virus (EBV) is a pathogenic virus associated with gastric cancer. The present study aimed to investigate the association between EBV infection, and the expression levels of ARID1A and PIK3CA in gastric cancer. Read More

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http://dx.doi.org/10.3892/mmr.2019.9886DOI Listing
March 2019
1 Read

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

The Ohio State University, Department of Cancer Biology and Genetics, Columbus, Ohio, United States ;

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach and colorectal cancers as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in-depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate MSI is absent or at least very rare in the most common and most well-studied histologic subtype, papillary carcinoma. In this study, we aim to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
February 2019
1 Read
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A case of gastric carcinoma with lymphoid stroma diagnosed by an endoscopic ultrasound-guided fine-needle biopsy.

J Clin Ultrasound 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology and Hematology/Oncology Department of medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Endoscopic ultrasound-guided sampling is indicated to achieve an accurate diagnosis of subepithelial lesions of the stomach when a standard biopsy fails. Gastric carcinoma with lymphoid stroma (GCLS) is located under the epithelial layer with dense lymphocytic infiltration, making a pathological diagnosis by a biopsy difficult. We herein report a case of the pathological diagnosis of GCLS using an endoscopic ultrasound-guided fine-needle biopsy. Read More

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http://dx.doi.org/10.1002/jcu.22696DOI Listing
February 2019

EBV miR-BART10-3p Promotes Cell Proliferation and Migration by Targeting DKK1.

Int J Biol Sci 2019 24;15(3):657-667. Epub 2019 Jan 24.

Department of Biomedicine & Health Sciences, Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

In Epstein-Barr virus (EBV)-infected epithelial cancers, HI A rightward transcript (BART) miRNAs are highly expressed. However, only a few target genes of BART miRNAs have been investigated. Our mRNA microarray data showed that DKK1 was markedly down-regulated in EBV-associated gastric carcinoma (EBVaGC) cells. Read More

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http://dx.doi.org/10.7150/ijbs.30099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367590PMC
January 2019

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
5 Reads

LINC00628 suppresses migration and invasion of hepatocellular carcinoma by its conserved region interacting with the promoter of VEGFA.

J Cell Physiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Accumulated evidence revealed that numerous long noncoding RNAs (lncRNAs) have been found to be involved in the development and progression of hepatocellular carcinoma (HCC). LINC00628, a member of lncRNAs, has been reported to act as a tumor suppressor in gastric cancer and breast cancer. However, its potential role in HCC still remains unknown. Read More

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http://dx.doi.org/10.1002/jcp.28233DOI Listing
February 2019
2 Reads

Estimation of Solid Tumor Doubling Times from Progression-Free Survival Plots Using a Novel Statistical Approach.

AAPS J 2019 Feb 8;21(2):27. Epub 2019 Feb 8.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Kapoor Hall, Buffalo, New York, 14214, USA.

Tumor doubling time can significantly affect the outcome of anticancer therapy, but it is very challenging to determine. Here, we present a statistical approach that extracts doubling times from progression-free survival (PFS) plots, which inherently contains information regarding the growth of solid tumors. Twelve cancers were investigated and multiple PFS plots were evaluated for each type. Read More

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http://dx.doi.org/10.1208/s12248-019-0302-5DOI Listing
February 2019
1 Read

Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.

J Formos Med Assoc 2019 Feb 5. Epub 2019 Feb 5.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.016DOI Listing
February 2019
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TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.

Cancer Commun (Lond) 2019 Feb 6;39(1). Epub 2019 Feb 6.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, Guangdong, P.R. China.

Background: In our previous study, we identified a candidate tumor suppressor gene, testin LIM domain protein (TES), in primary gastric cancer (GC). TES contains three LIM domains, which are specific interacting regions for the cell adhesion and cytoskeleton regulatory proteins. Mena is a known cytoskeleton regulator that regulates the assembly of actin filaments and modulates cell adhesion and motility by interacting with Lamellipodin (Lpd). Read More

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http://dx.doi.org/10.1186/s40880-019-0347-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366075PMC
February 2019

Immuno-PET Imaging and Pharmacokinetics of an Anti-CEA scFv-based Trimerbody and Its Monomeric Counterpart in Human Gastric Carcinoma-Bearing Mice.

Mol Pharm 2019 Feb 18. Epub 2019 Feb 18.

Radiochemistry and Nuclear Imaging Group , CIC biomaGUNE , 20014 San Sebastián , Guipúzcoa , Spain.

Monoclonal antibodies (mAbs) are currently used as therapeutic agents in different types of cancer. However, mAbs and antibody fragments developed so far show suboptimal properties in terms of circulation time and tumor penetration/retention. Here, we report the radiolabeling, pharmacokinetic evaluation, and determination of tumor targeting capacity of the previously validated anti-CEA MFE23-scFv-based N-terminal trimerbody (MFE23-trimerbody), and the results are compared to those obtained for the monomeric MFE23-scFv. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01006DOI Listing
February 2019
1 Read

Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents.

Methods Mol Biol 2019 ;1866:83-94

AntiCancer, Inc., San Diego, CA, USA.

The elevated methionine (MET) requirement for the growth of tumors, first observed by Sugimura in 1959, termed MET dependence, is a potentially highly effective therapeutic target. Proof of this principle is that when MET restriction (MR) was initially established in co-cultures of cancer and normal cells, MET dependence could be exploited to selectively kill cancer cells without killing co-cultured normal cells. MET-dependent cells become reversibly blocked in the late S/G phase of the cell cycle under MR enabling selective and effective S-phase chemotherapy against these blocked cancer cells. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_8DOI Listing
January 2019
2 Reads

[Primary squamous cell carcinoma of the stomach. Report of three cases].

Rev Med Chil 2018 Dec;146(10):1205-1209

Departamento de Oncología Médica, Instituto Nacional de Cancerología, México.

Gastric squamous cell carcinoma (SCC) is a rare type of cancer. We report three patients with the tumor. A 65 years old male presenting with weight los and heartburn. Read More

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http://dx.doi.org/10.4067/S0034-98872018001001205DOI Listing
December 2018
3 Reads

Expression of protein disulfide isomerase A3 and its clinicopathological association in gastric cancer.

Oncol Rep 2019 Feb 5. Epub 2019 Feb 5.

Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo 113-8602, Japan.

Protein disulfide isomerase A3 (PDIA3) is a chaperone protein that supports the folding and processing of synthesized proteins. Its expression is associated with the prognosis of laryngeal cancer, hepatocellular carcinoma, diffuse glioma and uterine cervical cancer. In the present study, the expression levels of PDIA3 and its clinicopathological association were examined in 52 cases of gastric cancer (GC). Read More

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http://dx.doi.org/10.3892/or.2019.6999DOI Listing
February 2019
1 Read

MT1‑MMP promotes the proliferation and invasion of gastric carcinoma cells via regulating vimentin and E‑cadherin.

Mol Med Rep 2019 Jan 31. Epub 2019 Jan 31.

Department of Radiotherapy, The First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215006, P.R. China.

The present study aimed to explore the possible effects of membrane‑type 1 matrix metalloproteinase (MT1‑MMP) on gastric carcinoma cells proliferation and invasion. Immunohistochemistry analysis was conducted to measure MT1‑MMP expression level in 15 patients with gastric carcinoma. Subsequently, recombinant short hairpin RNA (shRNA) vectors targeting MT1‑MMP were constructed to silence the expression of MT1‑MMP in gastric carcinoma cells. Read More

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http://dx.doi.org/10.3892/mmr.2019.9918DOI Listing
January 2019