Search Our Scientific Publications & Authors

PLoS One 2021 14;16(6):e0252932. Epub 2021 Jun 14.

Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh.

The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein. Read More

Front Cell Dev Biol 2021 26;9:676319. Epub 2021 May 26.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Cancer-associated fibroblast (CAF)-derived exosomes play a major role in gastric carcinoma (GC) tumorigenesis. However, the mechanism behind the activity of circular RNAs in CAF-derived exosomes in GC remains unclear. In the present study, we identified differentially expressed circ_0088300 in GC tissues and plasma exosomes. Read More

Front Oncol 2021 28;11:605106. Epub 2021 May 28.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Objective: The objective of this study was to investigate family history (FH) of upper gastrointestinal (UGI) cancer and risk of esophageal squamous cell carcinoma (ESCC), gastric cardia carcinoma (GCC), and gastric non-cardia carcinoma (GNCC) in the Linxian General Population Nutrition Intervention Trial (NIT) cohort. Methods: This prospective analysis was conducted using the Linxian NIT cohort data. Subjects with FH of UGI cancer was treated as an exposed group while the remainders were considered as a comparison group. Read More

Breast Dis 2021 Jun 2. Epub 2021 Jun 2.

Radiology Department, Mansoura University Faculty of Medicine, Mansoura, Dakahlya, Egypt.

Background: Multiple primary malignancies are two or more malignancies in an individual without any relationship between the tumors. The development of improved diagnostic techniques, increased survival of cancer patients and the growing life expectancy have all contributed to the increased frequency of this phenomenon.

Objective: The aim of this study is to review the multidetector computed tomography (MDCT) findings of synchronous breast carcinoma and other solid malignancies. Read More

BMC Gastroenterol 2021 Jun 11;21(1):255. Epub 2021 Jun 11.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: The efficacy of endoscopic ultrasound (EUS) for determining the T category of gastric cancer is variable. The aim of this study was to evaluate the superiority of EUS by using the 6th edition American Joint Committee on Cancer (AJCC) staging system for stomach cancer compared to the new 7th/8th edition.

Methods: A retrospective analysis of clinical and EUS imaging features of 348 gastric carcinoma patients who underwent radical resection were retrospectively analyzed. Read More

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

Departments of Pathology Oncology Gastroenterology of the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Department of Pathology of the First Affiliated Hospital of Soochow University, Suzhou, China Department of Pathology and Laboratory Medicine of Veterans Affairs Boston Healthcare System, Harvard Medical School and Brigham and Women's Hospital, MA.

Papillary early gastric carcinoma (EGC) is believed to have a low risk of lymph node metastasis (LNM) and thus can be resected endoscopically. We observed anecdotally that some papillary EGC tumors showed conspicuous high-grade dysplastic features, but the significance of these observations is unknown. In this bicenter study we investigated papillary EGCs that were divided into high-grade (n=96) and low-grade (n=118) groups among 1136 consecutive EGC radical resection cases. Read More

Leuk Res Rep 2021 14;15:100244. Epub 2021 May 14.

Department of Hematopathology and Lab Medicine, Moffitt Cancer Center, Tampa, FL, USA.

Introduction: Myelodysplastic syndrome (MDS) are hematologic neoplasms characterized by morphologic dysplasia and ineffective hematopoiesis in the bone marrow. The only potentially curative therapy is stem cell transplant. However, relapse remains a major challenge and is seen in about 25-40% of cases. Read More

Eur Rev Med Pharmacol Sci 2021 May;25(10):3700-3708

Department of Oncology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.

Objective: This meta-analysis aimed to assess the association of MUC-2 expression with clinicopathological parameters in gastric carcinoma (GC) patients.

Materials And Methods: Clinical databases based on the study aim were searched in detail. The relative risk ratios (RRs) and associated 95% confidence intervals (95% CIs) were computed after eligible trials were included in the study. Read More

Mol Med Rep 2021 Aug 10;24(2). Epub 2021 Jun 10.

Department of Chemotherapy, Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell Transwell assay data in the article (featured in Figs. 2C and 4C) were strikingly similar to data appearing in different form in other articles by different authors at different research institutions, which were already under consideration for publication or had already been published elsewhere at the time of the present article's submission [C. Lai , 'MicroRNA‑133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin‑bundling protein 1', Mol Med Rep 12: 1473‑1478, 2015; and Y. Read More

Sci Rep 2021 Jun 9;11(1):12117. Epub 2021 Jun 9.

Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

The copy number (CN) gain of protooncogenes is a frequent finding in gastric carcinoma (GC), but its prognostic implication remains elusive. The study aimed to characterize the clinicopathological features, including prognosis, of GCs with copy number gains in multiple protooncogenes. Three hundred thirty-three patients with advanced GC were analyzed for their gene ratios in EGFR, GATA6, IGF2, and SETDB1 using droplet dPCR (ddPCR) for an accurate assessment of CN changes in target genes. Read More

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):555-561

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital.

A 52-year-old woman had a surgical history of breast cancer. A follow-up blood test showed that the level of carcinoembryonic antigen was elevated. Esophagogastroduodenoscopy revealed a Borrmann type IV tumor in the stomach, and biopsy revealed poorly differentiated adenocarcinoma with signet ring cells. Read More

Medicine (Baltimore) 2021 May;100(19):e25780

Department of Liver Transplantation & Laparoscopic Surgery, Center of Organ Transplantation, The 1st Affiliated Hospital of Xinjiang Medical University.

Rationale: Hepatocellular with tumor thrombi extending into 3 hepatic veins (HVs) and right atrium presents as a real clinical challenge. We report the first documented case of surgical resection of an advanced hepatocellular carcinoma (HCC) with extensive invasion to distal stomach, atrium and hepatic vasculatures.

Patient Concerns: We present a case of 48-years old man with abdominal mass accompanying shortness of breath after activities. Read More

Clin Exp Gastroenterol 2021 31;14:217-228. Epub 2021 May 31.

Departamento de Bioquímica, Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica.

Purpose: This preclinical study aims to determine the effect of drugs that alter isoprenoids and cholesterol metabolism in the homeostasis of gastric carcinoma cell lines in the search for new therapeutic targets for stomach cancer.

Materials And Methods: Primary (AGS) and metastatic (NCI-N87) gastric cancer cell lines were treated with simvastatin and terbinafine, two inhibitors of the mevalonate pathway, and avasimibe, an inhibitor of cholesterol esterification. Cell viability and growth were measured as well as cholesterol levels and the expression of the hydroxy methyl-glutaryl CoA reductase (HMGCR) and the LDL receptor (LDLR). Read More

Hum Pathol 2021 Jun 5. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

To evaluate cytokeratin 19 expression in normal and cancerous tissues, 15,977 samples from 122 tumor types and 608 samples of 76 normal tissue types were analyzed by immunohistochemistry. In normal tissues, CK19 expression occurred in epithelial cells of most glandular organs but was strictly limited to the basal cell layer of non-keratinizing squamous epithelium and absent in the skin. CK19 expression in ≥90% of cases was seen in 34% of the tumor entities including the adenocarcinomas of the pancreas (99. Read More

Cell Mol Biol Lett 2021 Jun 7;26(1):26. Epub 2021 Jun 7.

Department of General Surgery, First Affiliated Hospital of China Medical University, Liaoning Province Shenyang City Heping District Nanjingbei Road 155, Shenyang, 110001, Liaoning, People's Republic of China.

Background: Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription factor 3 (ATF3) n GC chemoresistance.

Methods: Expression of ATF3 was determined in GC cell lines (MNK45, SGC7901, and BGC823) and cisplatin (DDP)-resistant cells (SGC7901/DDP and BGC823/DDP). Read More

J Laparoendosc Adv Surg Tech A 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgery and Hospital de Gastroenterología "Dr. Carlos Bonorino Udaondo," Ciudad Autónoma de Buenos Aires, Argentina.

Patients with hereditary diffuse gastric cancer (HDGC) and germline mutations in the E-cadherin gene, , have a very high cumulative lifetime risk of developing diffuse gastric cancer. In these patients, it is formally recommended to perform a prophylactic total gastrectomy (PTG). We analyzed the course of patients with HDGC who have undergone PTG in our institution. Read More

J Clin Lab Anal 2021 Jun 7:e23866. Epub 2021 Jun 7.

Li Huili Hospital Affiliated to Ningbo University School, Ningbo, China.

Circular RNAs (circRNAs) constitute a class of covalently closed RNA molecules. With the continuous advancement of high-throughput sequencing technology and bioinformatics tools, many circRNAs have been identified in various human tissues and cell lines. Notably, recent studies have indicated that some circRNAs have translational functions. Read More

DNA Cell Biol 2021 Jun 4. Epub 2021 Jun 4.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Long noncoding RNAs (lncRNAs) play essential roles in the occurrence and development of multiple human cancers. An accumulating body of researches have investigated thymopoietin antisense RNA 1 (TMPO-AS1) as a newly discovered lncRNA, which functions as an oncogenic lncRNA that is upregulated in various human malignancies and associated with poor prognosis. Many studies have detected abnormally high expression levels of TMPO-AS1 in multiple cancers, such as lung cancer, breast cancer, colorectal cancer (CRC), hepatocellular carcinoma, CRC, gastric cancer, ovarian cancer, thyroid cancer, esophageal cancer, Wilms tumor, cervical cancer, retinoblastoma, bladder cancer, osteosarcoma, and prostate cancer. Read More

Methods Mol Biol 2021 ;2310:179-199

Clinica Medica "A. Murri", Department of Biosciences and Human Oncology (DIMO), Policlinico Hospital, University of Bari Medical School, Bari, Italy.

The liver is at the crossroad of key metabolic processes, which include detoxification, glycolipidic storage and export, and protein synthesis. The gut-liver axis, moreover, provides hepatocytes with a series of bacterial products and metabolites, which contribute to maintain liver function in health and disease. Breath tests (BTs) are developed as diagnostic tools for indirect, rapid, noninvasive assessment of several metabolic processes in the liver. Read More

Am J Cancer Res 2021 15;11(5):1803-1827. Epub 2021 May 15.

Department of Pathology, Carver College of Medicine, University of Iowa Iowa, IA, USA.

SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1, ESET, KMT1E) is a H3K9 methyltransferase involved in gene silencing. In recent years, SETDB1 has been implicated as an oncogene in various cancers, highlighting a critical need to better understand the mechanisms underlying SETDB1 amplification, overexpression, and activation. In the following review, we first examine the history of SETDB1, starting from its discovery in 1999 and ending with recent findings. Read More

J Cancer 2021 19;12(14):4362-4371. Epub 2021 May 19.

Department of General Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, Hubei 430060, China.

A deep and comprehensive understanding of factors that contribute to cancer initiation, progression, and evolution is of essential importance. Among them, the serine/threonine and tyrosine kinase-like kinases, also known as receptor interacting proteins (RIPs) or receptor interacting protein kinases (RIPKs), is emerging as important tumor-related proteins due to its complex regulation of cell survival, apoptosis, and necrosis. In this review, we mainly review the relevance of RIP to various malignant digestive neoplasms, including esophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, gallbladder cancer, cholangiocarcinoma, and pancreatic cancer. Read More

J Cancer 2021 13;12(13):4011-4024. Epub 2021 May 13.

Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Digestive system cancers (DSCs) have been recognized to be linked with high morbidity and mortality. Recent studies have reported that microRNA-10b (miR-10b) is abnormally expressed in DSCs and associated with prognosis. However, the inconclusive results and unknown underlying mechanisms promoted us to perform this study. Read More

Am J Surg Pathol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pathology, University of California at San Francisco, San Francisco, CA Department of Pathology, University of Washington, Seattle, WA Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL.

Most gastric cancers (GCs) are thought to develop via gastric intestinal metaplasia (GIM)-dysplasia-carcinoma pathway. Patients with extensive and/or incomplete GIM have been reported to have a higher risk of GC. GIM can also display dysplasia-like cytoarchitectural atypia limited to the bases of gastric pits without surface involvement. Read More

Int J Surg Case Rep 2021 May 29;83:106047. Epub 2021 May 29.

Department of Medical Oncology, Sentara Careplex Hospital, Hampton, VA, United States of America; Virginia Oncology Associates, Hampton, VA, United States of America.

Introduction: A BRCA-2 mutation carrier with a metachronous pancreatic adenocarcinoma (PC) and established peritoneal metastases is presented. Combined modality therapy including Cytoreductive Surgery (CS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) was associated with long-term disease-free survival.

Case Presentation: A 62-yr. Read More

BMC Gastroenterol 2021 Jun 6;21(1):248. Epub 2021 Jun 6.

Department of Hepatobiliary and Pancreatovascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

Background: Signet ring cell carcinoma (SRC) is a rare histological subtype of gallbladder adenocarcinoma. The current study evaluates the clinicopathologic features and prognosis of SRC.

Methods: Patients with adenocarcinoma of the gallbladder were identified in the Surveillance, Epidemiology, and End Results database from 1973 to 2016. Read More

Clin Case Rep 2021 May 24;9(5):e04325. Epub 2021 May 24.

Department of Gastroenterology Habib Thameur Hospital Tunis Tunisia.

Primary squamous cell carcinoma of the stomach is a rare type of gastric malignancies. Diagnosis criteria are well defined but diagnosis is generally late being made at an advanced stage with metastases explaining its poor diagnosis. Read More

Mutat Res 2021 Jan-Jun;787:108360. Epub 2020 Dec 4.

Program of Food Science and Technology, Division of Science and Technology, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, 519085, Guangdong Province, China. Electronic address:

ARID1A (AT-rich interactive domain 1A) is a newly discovered tumor suppressor gene, and its encoded product is an important component of the SWI/SNF chromatin remodeling complex. ARID1A plays an important role in cell proliferation, invasion and metastasis, apoptosis, cell cycle regulation, epithelial mesenchymal transition, and the regulation of other of biological behaviors. Recently, ARID1A mutations have been increasingly reported in esophageal adenocarcinoma, gastric cancer, colorectal cancer, hepatocellular carcinoma, cholangiocarcinoma, pancreatic cancer, and other malignant tumors of the digestive system. Read More

Bosn J Basic Med Sci 2021 May 12. Epub 2021 May 12.

Department of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Gastric cancer (GC) represents a widespread malignancy with a poor prognosis. Hence, discovering reliable biomarkers is necessary. The cell division cycle-associated protein (CDCA) family, comprising CDCA1-8, plays a key role in tumor progression. Read More

J Surg Oncol 2021 Jun 3. Epub 2021 Jun 3.

Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York, USA.

Background: The Ivor Lewis esophagectomy (ILE) remains the procedure of choice for localized middle or lower esophageal carcinoma. Nevertheless, anastomotic leak remains a common complication with rates from 3% to 25% and a stricture rate as high as 40%. The frequency of these complications suggests that the procedure itself may have inherent limitations including the use of potentially ischemic tissue for the esophagogastric anastomosis. Read More

Curr Cancer Drug Targets 2021 Jun 2. Epub 2021 Jun 2.

Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi'an 710021, China.

Background: Glioma is the most common intracranial primary tumour of adult humans, and its pathological mechanism and molecular characteristics are under investigation. CDK-associated cullin 1 (CACUL1) has been shown to regulate colorectal carcinoma, lung cancer and gastric cancer development.

Objective: This study aims to explore the role of CACUL1 in the pathogenesis of human glioma. Read More