49,512 results match your criteria Gastric Carcinoma


Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors.

Diagn Cytopathol 2018 Aug;46(8):663-669

Department of Pathology and Laboratory Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.

Background: Spindle cell neoplasms of the gastrointestinal (GI) tract constitute a wide group of lesions that may raise diagnostic difficulties on hematoxylin-eosin-stained slides. Appropriate endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) technique with sufficient cell block material for immunohistochemistry (IHC) can lead to accurate diagnosis.

Methods: This is a retrospective study of 29 cases obtained from our institution's records over a five-year period (2011-2015). Read More

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http://dx.doi.org/10.1002/dc.23976DOI Listing

Gastric-type endocervical adenocarcinoma with uterine corpus involvement mimicking primary endometrial carcinoma.

J Obstet Gynaecol Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Takatsuki General Hospital, Japan.

Differentiation of endocervical adenocarcinomas involving the uterine corpus from primary endometrial (EM) carcinomas involving the cervix is, not only clinically but also pathologically, often difficult. We report a case of gastric-type endocervical adenocarcinoma involving the corpus that could be correctly diagnosed because it was a unique endocervical adenocarcinoma subtype. A 69-year-old woman who presented with abnormal genital bleeding was diagnosed as having a uterine adenocarcinoma on pathological examination of EM biopsy. Read More

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http://dx.doi.org/10.1111/jog.13973DOI Listing

A hypothesis on paradoxical privileged portal vein metastasis of hepatocellular carcinoma. Can organ evolution shed light on patterns of human pathology, and vice versa?

Med Hypotheses 2019 May 25;126:109-128. Epub 2019 Mar 25.

Arrowhead Parmaceuticals, Madison, WI 53719, USA; University of Wisconsin, Madison, WI 53705, USA; University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

Unlike other carcinomas, hepatocellular carcinoma (HCC) metastasizes to distant organs relatively rarely. In contrast, it routinely metastasizes to liver vasculature/liver, affecting portal veins 3-10 times more often than hepatic veins. This portal metastatic predominance is traditionally rationalized within the model of a reverse portal flow, due to accompanying liver cirrhosis. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.019DOI Listing

Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination.

Cancers (Basel) 2019 Apr 19;11(4). Epub 2019 Apr 19.

INSERM U1053 Bordeaux Research in Translational Oncology, University of Bordeaux, 33076 Bordeaux CEDEX, France.

Gastric cancer is the third leading cause of cancer mortality worldwide. Cancer stem cells (CSC) are at the origin of tumor initiation, chemoresistance, and the formation of metastases. However, there is a lack of mouse models enabling the study of the metastatic process in gastric adenocarcinoma (GC). Read More

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http://dx.doi.org/10.3390/cancers11040560DOI Listing

How Does Ultrasound Manage Pancreatic Diseases? Ultrasound Findings and Scanning Maneuvers.

Authors:
Shinji Okaniwa

Gut Liver 2019 Apr 24. Epub 2019 Apr 24.

Department of Gastroenterology, Iida Municipal Hospital, Iida, Japan.

As ultrasound (US) is simple and less invasive than other imaging modalities, this technique is widely used for mass screening. However, visualizing the entire pancreas due to complicated anatomy, obesity and overlying gas can be difficult. US plays a key role in the diagnosis of pancreatic carcinoma (PC), of which tumors smaller than 10 mm (TS1a) and pancreatic carcinoma in situ (PCIS) are expected to have good prognosis. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18567DOI Listing
April 2019
1 Read

Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Bioprocess Engineering, Otto von Guericke University, Universitätsplatz 2, Magdeburg 39106, Germany. Electronic address:

Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic inflammatory bowel diseases (IBD) of the gastrointestinal tract. This study used non-invasive LC-MS/MS to find disease specific microbial and human proteins which might be used later for an easier diagnosis. Therefore, 17 healthy controls, 11 CD patients and 14 UC patients but also 13 Irritable Bowel Disease (IBS) patients, 8 Colon Adenoma (CA) patients, and 8 Gastric Carcinoma (GCA) patients were investigated. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.009DOI Listing

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux.

J Laparoendosc Adv Surg Tech A 2019 Apr 19. Epub 2019 Apr 19.

1 Department of Surgery and University of North Carolina, Chapel Hill, North Carolina.

Achalasia is a rare esophageal motility disorder that causes progressive dysphagia and regurgitation. The aim of treatment for achalasia is to provide symptom relief by reducing esophageal outflow resistance by disrupting the muscles at the level of the esophagogastric junction to allow esophageal emptying by gravity. A review of the literature concerning laparoscopic treatment of esophageal achalasia. Read More

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http://dx.doi.org/10.1089/lap.2019.0155DOI Listing

Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases-An endoscopy cross-sectional study.

Kaohsiung J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi-hospital-based endoscopy-survey cross-sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Read More

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http://dx.doi.org/10.1002/kjm2.12071DOI Listing

Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing
April 2019
1 Read

Case 265: Lemmel Syndrome or Biliary Obstruction Due to a Periampullary Duodenal Diverticulum.

Radiology 2019 May;291(2):542-545

From the Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608.

History A 70-year-old man presented to the emergency department with fever, chills, rigors, and upper abdominal discomfort. Physical examination revealed jaundice and mild right upper quadrant tenderness. Laboratory tests revealed an increased C-reactive protein level of 133 mg/L (normal range, 0. Read More

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http://pubs.rsna.org/doi/10.1148/radiol.2019162375
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http://dx.doi.org/10.1148/radiol.2019162375DOI Listing
May 2019
2 Reads

[Characteristics analysis of early gastric cancer under white light endoscopy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):302-306

Department of gastroenterology,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate endoscopic features of early gastric cancer and clinical features of the patients, which may be helpful to provide reasonable suggestions for physicians to diagnose early gastric cancer during preliminary screening of white light gastroscopy.

Methods: A total of 271 patients who received endoscopic submucosal dissection or surgical operation to confirm early gastric cancer in Peking University Third Hospital from Apr. 2009 to Jun. Read More

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April 2019
2 Reads

A Case of Hemorrhagic Gastric Metastasis from Hepatocellular Carcinoma Successfully Treated Using Coil Embolization of the Left Gastric Artery.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Japan.

A 62-year-old man initially underwent transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma (HCC). One year after the initial treatment, he developed anemia. Upper gastrointestinal endoscopy revealed irregularly elevated tumors in the lower anterior gastric body, which were diagnosed to be metastasis from HCC. Read More

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http://dx.doi.org/10.2169/internalmedicine.2172-18DOI Listing
April 2019
1 Read

UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.

Drug Dev Ind Pharm 2019 Apr 17:1-17. Epub 2019 Apr 17.

b Department of medical records management , the Second Affiliated Hospital of Mudanjiang Medical University , Mudanjiang , Heilongjiang , 157000 , P.R. China.

Purpose: Studies have determined that UNBS5162, recognized as a new naphthalimide, holds inhibitory effects in prostate and breast tumors, however its functional implication on gastric carcinoma is currently undetermined. Based on this, this study designed to assess the functional role of it on human gastric carcinoma and underlying mechanism of action.

Methods: Cell Counting Kit-8 (CCK-8) assay, transwell assay, and flow cytometry were used to assess capabilities of SGC-7901 cell proliferation, invasion/migration, and apoptosis, respectively. Read More

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http://dx.doi.org/10.1080/03639045.2019.1607870DOI Listing

Case of successful endoscopic ultrasonography-guided gastrojejunostomy for gastric outlet obstruction caused by gallbladder carcinoma.

Dig Endosc 2019 Apr;31 Suppl 1:66-67

Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1111/den.13360DOI Listing

Dynamic Contrast-Enhanced Ultrasound of Gastric Cancer: Correlation with Perfusion CT and Histopathology.

Korean J Radiol 2019 May;20(5):781-790

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objective: To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features.

Materials And Methods: This prospective study was approved by our Institutional Review Board. We included 43 patients with pathologically-proven gastric cancers undergoing CEUS using SonoVue® (Bracco) and PCT on the same day. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2018.02
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http://dx.doi.org/10.3348/kjr.2018.0273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470092PMC
May 2019
3 Reads

Significance of Intramural Metastasis in Patients with Esophageal Squamous Cell Carcinoma: An Indicator of Aggressive Cancer Behavior.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Intramural metastasis (IM) is occasionally noted in patients with esophageal squamous cell carcinoma (ESCC). However, few recent studies have investigated the clinicopathological characteristics of IM and its survival impact. The present study aimed to clarify the clinicopathological and prognostic significance of IM in patients with ESCC. Read More

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http://dx.doi.org/10.1007/s00268-019-05004-zDOI Listing
April 2019
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The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components.

J Oncol 2019 12;2019:3671268. Epub 2019 Mar 12.

Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice. Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent.

Methods: We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component. Read More

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https://www.hindawi.com/journals/jo/2019/3671268/
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http://dx.doi.org/10.1155/2019/3671268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434268PMC
March 2019
2 Reads

Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features.

Gastric Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China.

Objectives: Hepatoid adenocarcinoma of the stomach (HAS) is characterized by histological resemblance to hepatocellular carcinoma and a poor prognosis. The aim of this study is to elucidate the clinicopathological and molecular characteristics of HAS.

Methods: Forty-two patients with HAS who received gastrectomy were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s10120-019-00965-5DOI Listing
April 2019
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LncRNA GASL1 inhibits tumor growth in gastric carcinoma by inactivating the Wnt/β-catenin signaling pathway.

Exp Ther Med 2019 May 18;17(5):4039-4045. Epub 2019 Mar 18.

Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Growth arrest associated lncRNA 1 (GASL1) is a newly discovered tumor suppressor long non-coding RNA (lncRNA) in osteosarcoma; however its role in other malignancies remains unknown. The aim of the present study was to investigate the involvement of GASL1 in gastric cancer. In the current study, gastric cancer tissue and adjacent healthy tissue samples were collected from patients with gastric carcinoma, and blood samples were collected from patients with gastric carcinoma and healthy controls to detect the expression of serum GASL1. Read More

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http://dx.doi.org/10.3892/etm.2019.7409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447894PMC
May 2019
1 Read

A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo-YAP signaling pathway.

Onco Targets Ther 2019 27;12:2259-2269. Epub 2019 Mar 27.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325027, People's Republic of China,

Purpose: Gastric carcinoma is the second most frequently diagnosed cancer and leading cause of cancer death in China. As a new generation of cancer therapeutic drug, CL-6, a curcumin derivative, shows better bioavailability than curcumin, which has shown anticancer effects in gastric cancer (GC). However, whether CL-6 shows similar activities in GC has not been examined. Read More

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http://dx.doi.org/10.2147/OTT.S196914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441554PMC

Long non-coding RNA GEHT1 promoted the proliferation of ovarian cancer cells via modulating the protein stability of HIF1α.

Authors:
Dan Liu Hao Li

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Gynecology, The People`s Hospital of Hanchuan city, Hanchuan, China

Cancer cells preferentially metabolize glucose via the aerobic glycolysis pathway, which is also named as Warburg effect. Increasing evidence has suggested that suppression of glycolysis inhibits the progression of cancers. In this study, we found that the long non-coding RNA gastric carcinoma high expressed transcript 1 (GHET1) was overexpressed in ovarian cancer tissues and cell lines. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20181650
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http://dx.doi.org/10.1042/BSR20181650DOI Listing
April 2019
2 Reads

CircLMTK2 acts as a novel tumor suppressor in gastric cancer.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 of Dong'an Road, Shanghai, 200032, China

Recently, circRNAs have been found to play regulatory roles in cancer. In the present study, we aimed to investigate the characteristics and effect of circLMTK2 and its potential role as a novel biomarker in cases of gastric cancer (GC). 111 pairs of clinical tissues from patients were collected for circLMTK2 expression investigation. Read More

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http://dx.doi.org/10.1042/BSR20190363DOI Listing

Polyacetylenes from the Roots of King.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.

A phytochemical investigation of the roots of led to the isolation of seven polyacetylenes, including five new compounds (-) and two known ones (-). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Read More

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https://www.mdpi.com/1420-3049/24/7/1291
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http://dx.doi.org/10.3390/molecules24071291DOI Listing
April 2019
2 Reads

Solitary adrenal metastasis from advanced gastric cancer invading duodenal bulb with situs inversus totalis: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15244

Department of the General Surgery.

Rationale: Situs invsersus totalis (SIT) is a rare anomaly featured by complete inversion of abdominal and thoracic organs. Adrenal metastasis is often encountered as part of advanced systemic dissemination, which is usually unresectable. Few published cases reported the adrenal metastasis from gastric cancer with SIT and the treatment of gastrectomy combined with adrenalectomy, especially with intraoperative radiotherapy (IORT). Read More

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http://dx.doi.org/10.1097/MD.0000000000015244DOI Listing
April 2019
1 Read

Divergolides T⁻W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete sp. KFD18.

Mar Drugs 2019 Apr 11;17(4). Epub 2019 Apr 11.

College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China.

Four new ansamycins, named divergolides T-W (-), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined by spectroscopic data and single-crystal X-ray diffraction analysis. Read More

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https://www.mdpi.com/1660-3397/17/4/219
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http://dx.doi.org/10.3390/md17040219DOI Listing
April 2019
2 Reads

[Updated German S3 guidelines on esophageal cancer and supplements from a surgical perspective].

Chirurg 2019 Apr 11. Epub 2019 Apr 11.

Klinik für Innere Medizin, Klinikum Bremen-Ost, Bremen, Deutschland.

The updated German S3 guidelines recommend transthoracic subtotal esophagectomy with 2‑field lymphadenectomy for surgical treatment of esophageal cancer in patients with squamous cell carcinoma and adenocarcinoma of the esophagogastric (AEG type I) junction of the middle and lower third. For AEG type III transhiatal extended total gastrectomy with distal esophageal resection is favored. Patients with AEG type II can be treated by both procedures under the prerequisite that an R0 resection can be achieved. Read More

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http://dx.doi.org/10.1007/s00104-019-0954-9DOI Listing
April 2019
1 Read

Coexistence of Gastric Cancer and Multiple Small Gastrointestinal Stromal Tumors: Report of a Unique Case and Review of the Literature.

Authors:
Helen J Trihia

Gastrointest Tumors 2019 Feb 21;5(3-4):63-67. Epub 2018 Dec 21.

Department of Pathology, "Metaxas" Cancer Hospital, Piraeus, Greece.

Background: In recent years, the synchronous occurrence of tumors of different histotypes arising in the same organ has been reported more frequently in the literature. The simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) has been documented rarely.

Summary: The coexistence of primary gastric adenocarcinoma and GIST has been detected incidentally on gastric mucosa, serosa or occasionally intramurally, at surgery, or gastroscopy for other reasons. Read More

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http://dx.doi.org/10.1159/000495178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422145PMC
February 2019
1 Read

Constitutive activation of the canonical NF-κB signaling pathway in EBV-associated gastric carcinoma.

Virology 2019 Apr 1;532:1-10. Epub 2019 Apr 1.

Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao, 266021, China. Electronic address:

EBV-associated gastric carcinoma (EBVaGC) is a specific subgroup of gastric carcinoma, and the multifunctional transcriptional factor NF-κB may contribute to its tumorigenesis. In this study, we comprehensively characterized NF-κB signaling in EBVaGC using qRT-PCR, western blot, immunofluorescence assays, ELISA, and immunohistochemistry staining. NF-κB-signaling inhibitors may inhibit the growth of EBVaGC cells and induce significant apoptosis. Read More

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http://dx.doi.org/10.1016/j.virol.2019.03.019DOI Listing
April 2019
1 Read

CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro.

FEBS Open Bio 2019 Apr 11. Epub 2019 Apr 11.

Department of Pathology, Anhui Medical University, Hefei, Anhui, 230032, China.

CORO1C (coronin-like actin-binding protein 1C) is a member of the WD repeat protein family which regulates actin-dependent processes by assembling F-actin. CORO1C was previously reported to promote metastasis in breast cancer and lung-squamous cell carcinoma. Here, we investigated the role of CORO1C in gastric cancer. Read More

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http://dx.doi.org/10.1002/2211-5463.12639DOI Listing

Optimal management of gastroesophageal junction cancer.

Cancer 2019 Apr 11. Epub 2019 Apr 11.

Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Although recent decades have witnessed incremental improvements in the treatment of gastroesophageal junction (GEJ) carcinoma, outcomes remain modest. For locally advanced esophageal cancer, the addition of chemotherapy and/or radiation to surgery is considered the standard of care. Chemotherapy remains the primary treatment for metastatic disease and improves survival over best supportive care. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32066
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http://dx.doi.org/10.1002/cncr.32066DOI Listing
April 2019
3 Reads

Tumour stage and resection margin status are independent survival factors following partial pancreatoduodenectomy for duodenal adenocarcinoma.

Langenbecks Arch Surg 2019 Apr 10. Epub 2019 Apr 10.

Department of Molecular and Clinical Cancer Medicine, Institution of Translational Medicine, University of Liverpool, 2nd Floor Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.

Introduction: There is limited published evidence on duodenal carcinoma due to its rarity. This study aimed to evaluate gastric outlet obstruction and obstructive jaundice along with pathological variables as survival factors in patients with duodenal adenocarcinoma following resection.

Methods: Survival factor analysis was undertaken in patients undergoing duodenal cancer surgery from 1997 to 2015 in a single centre. Read More

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http://dx.doi.org/10.1007/s00423-019-01779-wDOI Listing
April 2019
1 Read

Inter-observer Reproducibility in the Pathologic Diagnosis of Gastric Intraepithelial Neoplasia and Early Carcinoma in Endoscopic Submucosal Dissection Specimens: A Multi-center Study.

Cancer Res Treat 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea.

Purpose: The diagnostic criteria of gastric intraepithelial neoplasia (IEN) are controversial across the world. We investigated how many discrepancies occur in the pathologic diagnosis of IEN and early gastric carcinoma in endoscopic submucosal dissection (ESD) specimens, and evaluated the reasons of the discordance.

Materials And Methods: We retrospectively reviewed 1,202 ESD specimens that were originally diagnosed as gastric IEN and early carcinoma at 12 institutions. Read More

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http://dx.doi.org/10.4143/crt.2019.019DOI Listing
April 2019
1 Read

Mixed ductal-acinar cell carcinoma of the pancreas: A case report.

Mol Clin Oncol 2019 May 20;10(5):516-520. Epub 2019 Mar 20.

Department of Surgery, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.

Mixed carcinoma of the pancreas is defined as the concurrent existence of pancreatic ductal carcinoma, acinar cell carcinoma, and/or islet cell carcinoma within the same neoplasm. We herein report a rare case of mixed ductal-acinar cell carcinoma in a 74-year-old man who was undergoing treatment for hypertension and diabetes at another hospital. After an abrupt worsening of his blood glucose control, the patient was referred to our hospital for further evaluation. Read More

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http://dx.doi.org/10.3892/mco.2019.1831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449909PMC

Multiple primary malignancies of six organs in a Japanese male patient: A case report.

Mol Clin Oncol 2019 May 4;10(5):511-515. Epub 2019 Mar 4.

Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama 330-8503, Japan.

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. Read More

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http://dx.doi.org/10.3892/mco.2019.1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449908PMC
May 2019
2 Reads

Apatinib and S-1 combination therapy for the treatment of advanced head and neck neoplasms: Three case reports.

J Cancer Res Ther 2019 ;15(2):442-446

Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.

Apatinib, one of the novel oral antiangiogenic agents, shows survival benefits in treating advanced or metastatic gastric adenocarcinoma. However, its efficacy in treating advanced head and neck neoplasms has not been reported. Herein, three elderly men with advanced head and neck neoplasms were treated with apatinib and S-1. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_894_18DOI Listing
January 2019
2 Reads

Transcatheter arterial chemoembolization experience for advanced hepatocellular carcinoma with right atrial tumor thrombus.

J Cancer Res Ther 2019 ;15(2):305-311

Department of Interventional Therapy, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.

Background: Hepatocellular carcinoma (HCC) with tumor thrombus extending to the inferior vena cava (IVC) and right atrium (RA) is rare, which is generally associated with serial syndromes and poor prognosis. The results of earlier observations revealed that the median survival was 1-5 months after diagnosis for untreated patients. The prognosis was poor with surgery, radiotherapy, transarterial chemoembolization (TACE), and chemotherapy. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_923_17DOI Listing
January 2019

Prospective and prognostic factors for hepatic metastasis of gastric carcinoma: A retrospective analysis.

J Cancer Res Ther 2019 ;15(2):298-304

Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, Zhongshan, Dalian, Liaoning Province, China.

Aims: The aim of the study was to prospectively explore the prognostic factor for gastric cancer with liver metastasis (GCLM), since no prognostic factor was reported to be consistently significant across studies.

Patients And Methods: One hundred and five patients with GCLM treated at our center between January 1, 2010, and March 31, 2016, were included and their clinical data were retrospectively analyzed. The univariate analyses were first applied for identify the potential independent prognostic and predictive factors for liver metastasis. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_576_17DOI Listing
January 2019
1 Read

Where does signet-ring cell carcinoma come from and where does it go?

Authors:
Tomio Arai

Gastric Cancer 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.

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http://dx.doi.org/10.1007/s10120-019-00960-wDOI Listing

Gastric Heterotopic Pancreas Presenting as Abdominal Pain with Acute and Chronic Pancreatitis in the Resected Specimen.

Case Rep Gastrointest Med 2019 6;2019:2021712. Epub 2019 Mar 6.

Warren Alpert Medical School, Brown University, Providence, RI, USA.

Heterotopic pancreas, also known as ectopic pancreas, is pancreatic tissue located outside the pancreatic parenchyma without vascular or ductal communication with the gland. Ectopic pancreas is rarely symptomatic, typically detected incidentally at surgery or autopsy. Eighty-five to 90% are in the upper GI tract, especially the gastric antrum. Read More

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http://dx.doi.org/10.1155/2019/2021712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431401PMC
March 2019
2 Reads

circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer.

Dis Markers 2019 6;2019:2473652. Epub 2019 Mar 6.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.

Background: Circular RNAs have been implicated in various malignancies and can function as potential biomarkers for cancers. Reportedly, circSMARCA5 was downregulated in hepatocellular carcinoma and glioblastoma multiforme, but upregulated in prostate cancer. The functional roles and clinical significance of circSMARCA5 still remain unknown in the context of gastric cancer (GC). Read More

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http://dx.doi.org/10.1155/2019/2473652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431400PMC
March 2019
1 Read

Severe gastrointestinal hemorrhage related to everolimus: a case report.

Clin J Gastroenterol 2019 Apr 6. Epub 2019 Apr 6.

Department of Surgery, The Jikei University School of Medicine, 3-19-18 Nishi-shinbashi, Minato-ku, Tokyo, 105-8471, Japan.

Everolimus is an mTOR (the mammalian target of rapamycin) inhibitor, which is used for the treatment of advanced renal cell carcinoma. Life-threatening hemorrhages are extremely rare adverse effect of everolimus. We herein report a successfully treated case of severe everolimus-related gastrointestinal hemorrhage by emergency surgical resection for patient with advanced renal cell carcinoma. Read More

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http://link.springer.com/10.1007/s12328-019-00978-8
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http://dx.doi.org/10.1007/s12328-019-00978-8DOI Listing
April 2019
4 Reads

Aggressive Graphic/Surgical R0 Resection and Jejunal Interposition with Preservation of Mesojejunal Autonomic Nerves in Patients with Stage IV Esophagogastric Junction Adenocarcinoma: A Report of 3 Cases.

Am J Case Rep 2019 Apr 6;20:465-473. Epub 2019 Apr 6.

Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.

BACKGROUND Three patients with stage IV esophagogastric junction cancer (EGJC) underwent extended resection to achieve a graphic/surgical R0 status (no visible remnant of viable tumor in imaging/surgical findings) and adjuvant chemotherapy from the early postoperative period. We also introduced use of our digestive reconstruction technique in these patients. CASE REPORT We used jejunal interposition for digestive reconstruction, which involved end-to-end jejunojejunostomy with a biofragmentable anastomosis ring. Read More

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http://dx.doi.org/10.12659/AJCR.913960DOI Listing
April 2019
3 Reads

Five-year Recurrence-free Survival After Surgery Followed by Oral Chemotherapy for Gastric Cancer With Portal Vein Tumor Thrombosis.

Anticancer Res 2019 Apr;39(4):2233-2238

Department of Surgery, Kumamoto Chuo hospital, Kumamoto, Japan.

Gastric cancer with portal vein tumor thrombosis (GC-PVTT) is a rare condition with a very poor prognosis. A 64-year-old man with GC-PVTT was admitted to our hospital. His carcinoembryonic antigen level was slightly elevated (17. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13339DOI Listing
April 2019
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Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review.

Anticancer Res 2019 Apr;39(4):1651-1660

General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy.

Background: Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. Read More

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http://dx.doi.org/10.21873/anticanres.13270DOI Listing
April 2019
1.872 Impact Factor

A rare case of linitis plastica of the colon from ovarian carcinoma.

J Surg Case Rep 2019 Mar 29;2019(3):rjz089. Epub 2019 Mar 29.

Department of Surgery, Ballarat Base Hospital, Ballarat, Victoria, Australia.

Linitis plastica refers to the diffuse submucosal spread of scirrhous carcinoma in a hollow organ, resulting in constriction and inelasticity of the organ. It is best known to occur in the stomach. Linitis plastica of the colon is rare, and more commonly occurs in the rectum and sigmoid colon from metastatic gastric or breast cancer. Read More

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http://dx.doi.org/10.1093/jscr/rjz089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439517PMC
March 2019
2 Reads

Isolated Drain Site Metastasis After Open Resection in Ileal Adenocarcinoma-an Uncommon Site.

Indian J Surg Oncol 2019 Mar 12;10(1):37-39. Epub 2018 May 12.

Department of Surgical Oncology, JIPMER, Puducherry, Puducherry, India.

Although port site implants have been described after laparoscopic resection for gastrointestinal malignancies, drain site metastasis in solid intra-abdominal tumor after open resection is a rare phenomenon. Only few cases have been reported in literature describing drain site metastasis after open resection for carcinoma in the colon, stomach, cervix etc. Isolated drain site metastasis is even rare. Read More

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http://dx.doi.org/10.1007/s13193-018-0745-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414717PMC
March 2019
3 Reads

GHET1 acts as a prognostic indicator and functions an oncogenic lncRNA in cervical cancer.

Biosci Rep 2019 Apr 4. Epub 2019 Apr 4.

Maternal and Child Health Hospital of Tangshan, Tangshan, China

Gastric carcinoma proliferation enhancing transcript 1 (GHET1) has been suggested to serve as a promising oncogenic long non‑coding RNA (lncRNA) in various types of human cancer. However, the role of GHET1 remained unknown in cervical cancer. In our study, we found GHET1 expression was markedly elevated in cervical cancer tissue specimens and cell lines compared to adjacent normal cervical tissue specimens and human normal cervical cell line, respectively. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182506
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http://dx.doi.org/10.1042/BSR20182506DOI Listing
April 2019
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Downstaging of lymph node metastasis after neoadjuvant intraperitoneal and systemic chemotherapy in gastric carcinoma with peritoneal metastasis.

Eur J Surg Oncol 2019 Mar 9. Epub 2019 Mar 9.

NPO to Support Peritoneal Dissemination Treatment, Osaka, Japan; Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, Kishiwada, Japan; Department of Surgery, Kusatsu Genaral Hospital, Shiga, Japan. Electronic address:

Purpose: The aim of the present study was to evaluate the clinical features and prognosis of lymph node metastasis (LNM) in gastric cancer patients with peritoneal metastasis (PM) after neoadjuvant intraperitoneal and systemic chemotherapy.

Methods: A total of 69 gastric cancer patients with PM and LNM who received neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) of intraperitoneal docetaxel (DXT) and cisplatin (CDDP); intravenous chemotherapy of DXT and CDDP and oral S-1in Kishiwada Tokushukai Hospital between January 2008 and February 2017. After surgical resection, the response of LNMs was studied to confirm the effect of NIPS on LNMs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983193033
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http://dx.doi.org/10.1016/j.ejso.2019.03.011DOI Listing
March 2019
9 Reads