128,903 results match your criteria Gastric Cancer


Prognostic Nutritional Index Predicts Outcomes of Patients after Gastrectomy for Cancer: A Systematic Review and Meta-Analysis of Nonrandomized Studies.

Nutr Cancer 2019 Feb 22:1-12. Epub 2019 Feb 22.

a Department of General Surgery , The Third Hospital of Mianyang the Mental Health Center of Sichuan , Mianyang , Sichuan , China.

Objective: The primary aim of this systematic review was to evaluate the survival predication value of preoperative prognostic nutritional index (PNI) in patients with gastric cancer. The second aim was to explore the relationship between preoperative PNI and clinicopathological features.

Methods: A systematic search of the electronic databases identified studies that investigated the association of preoperative PNI with short or long-term outcomes among patients after gastrectomy for cancer. Read More

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http://dx.doi.org/10.1080/01635581.2019.1577986DOI Listing
February 2019

Down-regulated lncRNA SLC25A5-AS1 facilitates cell growth and inhibits apoptosis via miR-19a-3p/PTEN/PI3K/AKT signalling pathway in gastric cancer.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.

Mounting evidence has illustrated the vital roles of long non-coding RNAs (lncRNAs in gastric cancer (GC). Nevertheless, the majority of their roles and mechanisms in GC are still largely unknown. In this study, we investigate the roles of lncRNA SLC25A5-AS1 on tumourigenesis and explore its potential mechanisms in GC. Read More

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http://dx.doi.org/10.1111/jcmm.14200DOI Listing
February 2019

An intramucosal gastric cancer on the prepylorus completely resected by underwater endoscopic mucosal resection.

Dig Endosc 2019 Feb 21. Epub 2019 Feb 21.

Department of Endoscopy, Hiroshima City Hospital, 7-33 Moto-machi, Naka-ku, Hiroshima, 730-8518, Japan.

Underwater endoscopic mucosal resection (UEMR) has been reported to be a useful technique for various situations. Although the efficacy of UEMR for gastric polyp has been reported, there are no reports of UEMR for gastric cancer. We herein present the first case in which UEMR was useful for the treatment of early gastric cancer located on the prepylorus. Read More

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http://dx.doi.org/10.1111/den.13375DOI Listing
February 2019

Upregulation of DLEU1 expression by epigenetic modification promotes tumorigenesis in human cancer.

J Cell Physiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

The function of DLEU1 in human cancer is largely unknown. The Cancer Genome Atlas data were applied to identify the landscape of differential genes between tumor tissues and normal tissues, which was further validated by our cohort data and pan-cancer data including 33 cancer types with 11,060 patients. Next, DLEU1 was selected to validate the novel finding and result showed that it promoted tumorigenesis in vitro and in vivo. Read More

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http://dx.doi.org/10.1002/jcp.28364DOI Listing
February 2019

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers.

Pathol Oncol Res 2019 Feb 21. Epub 2019 Feb 21.

Genome Research Chair, College of Science, King Saud University, Riyadh, Saudi Arabia.

Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Several lncRNAs can be classified into oncogenes and tumor suppressor genes depending on their function in cancer. A maternally expressed gene 3 (MEG3) gene transcripts a 1. Read More

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http://dx.doi.org/10.1007/s12253-019-00614-3DOI Listing
February 2019

Identification of molecular biomarkers for the diagnosis of gastric cancer and lymph-node metastasis.

Gastroenterol Rep (Oxf) 2019 Feb 13;7(1):57-66. Epub 2018 Aug 13.

Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.

Background And Objective: Biomarkers are important tools for prompt diagnosis of cancer. This study aimed to identify reliable biomarkers for clinical applications in the diagnosis of gastric cancer and lymph-node (LN) metastasis.

Methods: Between 1 December 2014 and 31 December 2015, we prospectively collected samples of gastric-cancer tissues, corresponding matched-pair normal gastric mucosa, and their peri-gastric metastatic and non-metastatic LNs to identify quantitatively reliable genes using quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1093/gastro/goy023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375354PMC
February 2019

International consensus on natural orifice specimen extraction surgery (NOSES) for colorectal cancer.

Gastroenterol Rep (Oxf) 2019 Feb 23;7(1):24-31. Epub 2019 Jan 23.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing, China.

In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits of NOSES including reduction in postoperative pain and wound complications, less use of postoperative analgesic, faster recovery of bowel function, shorter length of hospital stay, better cosmetic and psychological effect have been described in colorectal surgery. Despite significant decrease in surgical trauma of NOSES have been observed, the potential pitfalls of this technique have been demonstrated. Read More

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http://dx.doi.org/10.1093/gastro/goy055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375350PMC
February 2019

A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series.

Ann Med Surg (Lond) 2019 Mar 30;39:10-15. Epub 2019 Jan 30.

Department of Surgery, Jichi Medical University, Tochigi, Japan.

Background And Objectives: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on prognosis of positive cytology were analyzed. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370578PMC

Association of host immunity with infection in recurrent gastric cancer.

Infect Agent Cancer 2019 11;14. Epub 2019 Feb 11.

2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Background: infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. Read More

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http://dx.doi.org/10.1186/s13027-019-0221-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371572PMC
February 2019

Differential effects, on oncogenic pathway signalling, by derivatives of the HNF4 α inhibitor BI6015.

Br J Cancer 2019 Feb 22. Epub 2019 Feb 22.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, Korea.

Background: Gastric cancer (GC) is a highly heterogeneous disease with few "targeted" therapeutic options. Previously, we demonstrated involvement of the transcription factor HNF4α in human GC tumours, and the developmental signal mediator, WNT5A, as a prognostic GC biomarker. One previously developed HNF4α antagonist, BI6015, while not advancing beyond preclinical stages, remains useful for studying GC. Read More

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http://dx.doi.org/10.1038/s41416-018-0374-5DOI Listing
February 2019

Depletion of death-associated protein-3 induces chemoresistance in gastric cancer cells through the β-catenin/LGR5/Bcl-2 axis.

J Investig Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.

Previously, we demonstrated that death-associated protein-3 (DAP3) loss drives chemoresistance in gastric cancer cells. In the present study, we aimed to determine the underlying molecular mechanism. The effect of DAP3 silencing on β-catenin signaling was assessed. Read More

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http://dx.doi.org/10.1136/jim-2018-000934DOI Listing
February 2019

2-Hydroxylated fatty acids as candidates of novel drugs to promote chemosensitivity of gastric cancer.

Authors:
Kazuhito Tsuboi

EBioMedicine 2019 Feb 18. Epub 2019 Feb 18.

Department of Pharmacology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.02.029DOI Listing
February 2019

Strategy for treatment of stage IV human epidermal growth factor 2-positive gastric cancer: a case report.

J Med Case Rep 2019 Feb 22;13(1):42. Epub 2019 Feb 22.

Department of Surgery, Osaka Red Cross Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.

Background: The prognosis of stage IV gastric cancer and human epidermal growth factor 2 (HER2)-positive gastric cancer is poor, although new drugs and regimens have been developed. We report a case of a patient with stage IV HER2-positive gastric cancer treated successfully by conversion therapy and trastuzumab.

Case Presentation: The patient was a 73-year-old Japanese man diagnosed as L, type 3, circ, T4aNxCy1P1M1, stage IV (the Japanese classification of gastric carcinoma). Read More

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http://dx.doi.org/10.1186/s13256-019-2001-3DOI Listing
February 2019

Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review.

BMC Cancer 2019 Feb 21;19(1):164. Epub 2019 Feb 21.

Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Background: The association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.

Methods: We used two single nucleotide polymorphisms to determine ABO genotype in 4932 gastric cancer cases and 6158 controls of Chinese descent, and evaluated the associations of ABO blood groups and genotypes with risk of gastric cancer using multivariable logistic regression models. We also systematically reviewed published literature and performed a meta-analysis of all relevant studies. Read More

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http://dx.doi.org/10.1186/s12885-019-5355-4DOI Listing
February 2019

The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal.

Expert Rev Gastroenterol Hepatol 2019 Jan 13;13(1):17-24. Epub 2018 Nov 13.

f Department of Medicine , Michael E. DeBakey VA Medical Center, and Baylor College of Medicine , Houston , TX , USA.

Introduction: Gastric cancer is one of the top causes of cancer-related death worldwide. How to eliminate gastric cancer is an urgent public-health issue. Areas covered: In this review, we present up-to-date results of studies on gastric cancer prevention through the eradication of Helicobacter pylori and discuss strategies and obstacles for the implementation of population-wide screening and treatment of this pathogen to prevent gastric cancer. Read More

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http://dx.doi.org/10.1080/17474124.2019.1542299DOI Listing
January 2019

Oxaliplatin in perioperative chemotherapy for gastric and gastroesophageal junction (GEJ) adenocarcinoma.

Expert Rev Gastroenterol Hepatol 2019 Jan 21:1-7. Epub 2019 Jan 21.

b Comprehensive Cancer Center Freiburg (CCCF) , Medical Center - University of Freiburg , Freiburg , Germany.

Introduction: Platinum-based chemotherapy remains standard-of-care for gastric and gastroesophageal junction (GEJ) adenocarcinoma. For locally advanced resectable disease, perioperative treatment with cisplatin-based doublet or triplet chemotherapy regimens had been the predominant approach in Europe and the US, based on pivotal phase III trials including the MAGIC study. Results from more recent landmark studies including the German FLOT4 and the Asian CLASSIC trials have, however, triggered a shift from cisplatin towards oxaliplatin-based chemotherapy protocols in the perioperative setting. Read More

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http://dx.doi.org/10.1080/17474124.2019.1573143DOI Listing
January 2019

KCNMA1 Expression is Downregulated in Colorectal Cancer via Epigenetic Mechanisms.

Cancers (Basel) 2019 Feb 19;11(2). Epub 2019 Feb 19.

Department of Medical and Surgical Sciences and Advanced Technology "G.F. Ingrassia", University of Catania, Via Santa Sofia 86, 95123 Catania, Italy.

is a gene located at 10q22 that encodes the pore-forming α-subunit of the large-conductance Ca-activated K⁺ channel. is down-regulated in gastric carcinoma tumors, through hypermethylation of its promoter. In the present study, we have evaluated the expression levels of both in a mouse model of Colorectal Cancer (CRC) and in human CRC samples. Read More

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http://dx.doi.org/10.3390/cancers11020245DOI Listing
February 2019

SPHK1-induced autophagy in peritoneal mesothelial cell enhances gastric cancer peritoneal dissemination.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang, China.

Gastric cancer peritoneal dissemination (GCPD) has been recognized as the most common form of metastasis in advanced gastric cancer (GC), and the survival is pessimistic. The injury of mesothelial cells plays an important role in GCPD. However, its molecular mechanism is not entirely clear. Read More

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http://dx.doi.org/10.1002/cam4.2041DOI Listing
February 2019

Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial.

Cancer Med 2019 Feb 20. Epub 2019 Feb 20.

Shanghai Heavy ion and Proton Centre, Shanghai, China.

To evaluate the response and quality of life of palliative gastric radiotherapy in patients with symptomatic locally advanced gastric cancer. Patients with bleeding, pain or obstruction and were treated with palliative gastric radiotherapy to a dose of 36 Gy in 12 daily fractions. The primary outcomes were symptom response rates. Read More

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http://dx.doi.org/10.1002/cam4.2021DOI Listing
February 2019

Author's reply to letter to the editor: "After propensity score matching in long-term oncologic outcomes of robotic gastrectomy for gastric cancer compared with laparoscopic gastrectomy".

Gastric Cancer 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgery, Yonsei University College of Medicine, 50-1 Yonsei-ro Seodaemun-gu, Seoul, 120-752, Republic of Korea.

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http://dx.doi.org/10.1007/s10120-019-00933-zDOI Listing
February 2019

Imaging strategies in the management of gastric cancer: current role and future potential of MRI.

Br J Radiol 2019 Feb 21:20181044. Epub 2019 Feb 21.

1 Department of Surgery, University Medical Center Utrecht, Utrecht University , Utrecht , Netherlands.

Accurate preoperative staging of gastric cancer and the assessment of tumor response to neoadjuvant treatment is of importance for treatment and prognosis. Current imaging techniques, mainly endoscopic ultrasonography (EUS), computed tomography (CT) and F-fluorodeoxyglucose positron emission tomography (F-FDG PET), have their limitations. Historically, the role of magnetic resonance imaging (MRI) in gastric cancer has been limited, but with the continuous technical improvements, MRI has become a more potent imaging technique for gastrointestinal malignancies. Read More

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http://dx.doi.org/10.1259/bjr.20181044DOI Listing
February 2019

Ideal Screening for Gastric Cancer Might Vary Across Different Regions Worldwide.

Authors:
Kyosuke Kaji

Am J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Kanazawa Medical Association, Kanazawa, Ishikawa Japan.

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http://dx.doi.org/10.14309/ajg.0000000000000159DOI Listing
February 2019

D-Methionine Ameliorates Cisplatin-Induced Muscle Atrophy via Inhibition of Muscle Degradation Pathway.

Integr Cancer Ther 2019 Jan-Dec;18:1534735419828832

2 Chung Shan Medical University, Taichung, Taiwan.

Cisplatin induces anorexia, weight loss, loss of adipose tissue, skeletal muscle atrophy, and serious adverse effects that can cause premature termination of chemotherapy. The aim of this study was to use an animal model to assess cisplatin therapy (3 cycles) with and without d-methionine to investigate its protective effects on cisplatin-induced anorexia and skeletal muscle wasting. Wistar rats were divided into 3 groups and treated as follows: saline as control (group 1), intraperitoneal cisplatin once a week for 3 weeks (group 2), and intraperitoneal cisplatin once a week for 3 weeks plus oral administration of d-methionine (group 3). Read More

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http://dx.doi.org/10.1177/1534735419828832DOI Listing
February 2019

Single-arm confirmatory trial of laparoscopy-assisted total or proximal gastrectomy with nodal dissection for clinical stage I gastric cancer: Japan Clinical Oncology Group study JCOG1401.

Gastric Cancer 2019 Feb 20. Epub 2019 Feb 20.

Division of Gastric Surgery, Shizuoka Cancer Center, Nagaizumi, Japan.

Backgrounds: Laparoscopy-assisted distal gastrectomy (LADG) for gastric cancer is safe and feasible. In contrast, no prospective study evaluating the safety and efficacy of laparoscopy-assisted total gastrectomy (LATG) or laparoscopy-assisted proximal gastrectomy (LAPG) has been completed. We conducted a single-arm confirmatory trial to evaluate the safety of LATG/LAPG for clinical stage I (T1N0/T1N1/T2N0) proximal gastric cancer. Read More

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http://dx.doi.org/10.1007/s10120-019-00929-9DOI Listing
February 2019

Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients.

Gastric Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Venous thromboembolism (VTE) is highly associated with advanced gastric cancer (AGC) and is sometimes lethal. Predictors of VTE have not been identified, and the efficacy and safety of direct oral anticoagulants (DOACs) for AGC-associated VTE remain to be clarified.

Methods: A total of 188 AGC patients who started chemotherapy during the period from January 2014 to December 2017 in our institutions were retrospectively examined for the incidence of VTE, risk factors for VTE, and the efficacy and safety of DOAC-based anticoagulant therapy for VTE. Read More

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http://dx.doi.org/10.1007/s10120-019-00930-2DOI Listing
February 2019

Evaluating Dissemination of Adequate Lymphadenectomy for Gastric Cancer in the USA.

J Gastrointest Surg 2019 Feb 20. Epub 2019 Feb 20.

MedStar-Georgetown Surgical Outcomes Research Center, Washington, DC, USA.

Background: Adequate lymphadenectomy (AL) of 15+ lymph nodes comprises an important component of gastric cancer surgical therapy. Despite endorsement by the National Comprehensive Cancer Network and the Committee on Cancer, initial adoption of this paradigm has been relatively slow. The current analysis sought to perform an adjusted time-trend evaluation of the factors associated with AL and its dissemination. Read More

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http://dx.doi.org/10.1007/s11605-019-04138-8DOI Listing
February 2019

Distinct Expression Patterns of Two Tumor Necrosis Factor Superfamily Member 15 Gene Isoforms in Human Colon Cancer.

Dig Dis Sci 2019 Feb 20. Epub 2019 Feb 20.

Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.

Background: Tumor necrosis factor superfamily member 15 (TNFSF15) gene is involved in development of several cancers. It encodes two proteins: tumor necrosis factor ligand-related molecule 1A (TL1A) and vascular endothelial growth inhibitor 192 (VEGI-192). The main receptor for TL1A is death receptor 3 (DR3). Read More

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http://dx.doi.org/10.1007/s10620-019-05507-8DOI Listing
February 2019

Non-occlusive mesenteric ischemia associated with enteral feeding after esophagectomy for esophageal cancer: report of two cases and review of the literature.

Surg Case Rep 2019 Feb 20;5(1):36. Epub 2019 Feb 20.

Division of Esophageal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Background: Non-occlusive mesenteric ischemia (NOMI) is a rare but life-threatening complication of early postoperative enteral feeding. We herein report two patients who developed NOMI during enteral feeding after esophagectomy.

Case Presentation: In case 1, a 75-year-old man with no medical history was diagnosed with multiple primary cancers of the esophagus, stomach, and kidney. Read More

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http://dx.doi.org/10.1186/s40792-019-0580-2DOI Listing
February 2019

Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis.

J Gastrointest Oncol 2019 Feb;10(1):85-94

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.

Background: Gastric squamous cell carcinoma (GSCC) and gastric adenosquamous carcinoma (GASC) comprise less than 2% of gastric cancers. The current knowledge about clinical presentation, treatment modalities and outcomes of GSCC and GASC is limited. The aim of this study is to characterize the clinicopathological features, treatment modalities, and outcomes of GSCC and GASC in comparison to gastric adenocarcinoma (GAC) in National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.21037/jgo.2018.10.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351299PMC
February 2019

Comparison of endoscopic submucosal dissection with surgical gastrectomy for early gastric cancer: An updated meta-analysis.

World J Gastrointest Oncol 2019 Feb;11(2):161-171

School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.

Background: There are several surgical options for treating early gastric cancers (EGCs), such as endoscopic resection, laparoscopic or open gastrectomy with D1 or D2 lymphadenectomy. Endoscopic resection for EGC with low risk of lymph node metastasis has been widely accepted as a therapeutic alternative. The role of endoscopic submucosal dissection (ESD) in treating EGC is not well established, especially when compared with resection surgery cases in a long-term follow-up scope. Read More

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http://dx.doi.org/10.4251/wjgo.v11.i2.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379758PMC
February 2019

C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group.

World J Gastrointest Oncol 2019 Feb;11(2):139-152

Department of Gastroenterology, Dokuz Eylul University Faculty of Medicine, Izmir 35000, Turkey.

Background: Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is necessary. Read More

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http://dx.doi.org/10.4251/wjgo.v11.i2.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379754PMC
February 2019

Novel long non-coding RNA LINC02532 promotes gastric cancer cell proliferation, migration, and invasion .

World J Gastrointest Oncol 2019 Feb;11(2):91-101

Department of Gastroenterological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.

Background: Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is necessary. Read More

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http://dx.doi.org/10.4251/wjgo.v11.i2.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379752PMC
February 2019

Analysis the prognostic values of solute carrier (SLC) family 39 genes in gastric cancer.

Am J Transl Res 2019 15;11(1):486-498. Epub 2019 Jan 15.

Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation Hangzhou 310003, Zhejiang Province, China.

Background: Gastric cancer (GC) is one of the most common diagnosed cancer with poor prognosis. Solute carrier (SLC) family 39 genes encode membrane transport proteins, which control the influx of zinc and may play important roles in human disease including cancer. However, the prognostic value of individual SLC family 39 gene in gastric cancer patients remain unclear. Read More

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January 2019

MT1JP inhibits tumorigenesis and enhances cisplatin sensitivity of breast cancer cells through competitively binding to miR-24-3p.

Am J Transl Res 2019 15;11(1):245-256. Epub 2019 Jan 15.

Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine Shanghai, People's Republic of China.

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a key role in the development of many human cancers. MT1JP is a lncRNA that is reportedly involved in gastric cancer development, but a biological role and mechanism for MT1JP in breast cancer is unknown. Here, we found that MT1JP expression was significantly down-regulated in breast cancer tissues and cell lines, and that decreased MT1JP expression was associated with breast cancer progression and poor survival of breast cancer patients. Read More

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January 2019

lncRNA GHET1 knockdown suppresses breast cancer activity in vitro and in vivo.

Am J Transl Res 2019 15;11(1):31-44. Epub 2019 Jan 15.

Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

Long non-coding RNA gastric carcinoma high-expressed transcript 1 (lncRNA GHET1) is highly expressed in many tumors. The aim of the present study was to determine whether GHET1 inhibition decreases growth and metastasis of MCF-7 breast cancer cells by modulating epidermal growth factor receptor (EGFR) expression. In vitro, lncRNA GHET1 knockdown suppressed cell proliferation, migration, and invasion and enhanced cell apoptosis by maintaining MCF-7 cells in the G1 phase of the cell cycle. Read More

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January 2019

An investigation on the cytotoxicity and caspase-mediated apoptotic effect of biologically synthesized gold nanoparticles using on AGS gastric carcinoma cells.

Int J Nanomedicine 2019 5;14:951-962. Epub 2019 Feb 5.

Gastrointestinal Surgical Ward, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, China,

Background: Gastric cancer is the fourth most common cancer and second leading cause of cancer death worldwide. is used to treat nerve disorders, stiffness, rheumatism, ear ache, snake bite, and so on.

Methods: In this study, the reaction parameters were optimized to control the size of the nanoparticle, which was confirmed by transmission electron microscopy. Read More

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http://dx.doi.org/10.2147/IJN.S193064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368113PMC
February 2019

ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance.

Cell Death Dis 2019 Feb 20;10(3):173. Epub 2019 Feb 20.

Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

For gastric cancer (GC) control, metastasis and chemoresistance are the major challenges, accompanied with various stresses. Ataxin-2-like (ATXN2L) was discovered as a novel regulator of stress granules, yet its function in cancers remained unknown. Hence, we wanted to explore the functions of ATXN2L to see whether it participates in stress-related cancer malignant activities. Read More

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http://dx.doi.org/10.1038/s41419-019-1362-2DOI Listing
February 2019

Prognostic Value of Nodal Response After Preoperative Treatment of Gastric Adenocarcinoma.

J Natl Compr Canc Netw 2019 Feb;17(2):161-168

Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas; Department of Medicine, Baylor College of Medicine, Houston, Texas; Baylor College of Medicine, Houston, Texas; and Department of Surgery, Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas.

Pathologically positive lymph nodes (ypN+) after preoperative chemotherapy are associated with poor survival in patients with gastric cancer. Little is known about the association between response to preoperative therapy and the benefit of postoperative therapy. This retrospective cohort study of the National Cancer Database included patients with clinically node-positive (cN+) gastric cancer treated with preoperative therapy followed by surgery (2006-2014). Read More

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http://dx.doi.org/10.6004/jnccn.2018.7093DOI Listing
February 2019

Prognostic significance of positive circumferential resection margin post neoadjuvant chemotherapy in patients with esophageal or gastro-esophageal junction adenocarcinoma.

Eur J Surg Oncol 2019 Mar 24;45(3):439-445. Epub 2018 Oct 24.

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK. Electronic address:

Background: The aim of the present study was to assess the prognosis of patients with esophageal or gastroesophageal junction (E/GEJ) adenocarcinoma extending beyond the muscularis propria layer (≥ypT3) and positive circumferential resection margin (CRM), post neoadjuvant chemotherapy.

Methods: 177 patients were retrospectively studied. The majority (94. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.10.530DOI Listing

Activation of CD3 T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma.

Cancer Biol Ther 2019 Feb 20:1-11. Epub 2019 Feb 20.

a Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.

Most of gastric carcinoma (GC) is attributed to infection by Helicobacter pylori (H. pylori) but there is increasing evidence that the positive H. pylori status correlates with better prognosis in GC. Read More

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http://dx.doi.org/10.1080/15384047.2019.1579957DOI Listing
February 2019

Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review.

Pol J Pathol 2018 ;69(4):366-375

Carcinosarcoma is a rare malignant neoplasm, consisting of both epithelial and mesenchymal component. Primary gastric carcinosarcoma is rare and poorly understood. We reported clinicopathologic features of 4 cases and analysis of 76 cases published in the literature. Read More

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http://dx.doi.org/10.5114/pjp.2018.81696DOI Listing
January 2018

SERUM CYTOKINE OF IL-2, IL-10 AND IL-12 LEVELS IN PATIENTS WITH STOMACH ADENOCARCINOMA.

Arq Gastroenterol 2018 Oct-Dec;55(4):385-389

Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran.

Background: Gastric adenocarcinoma is the fourth most common cause of cancer-associated death worldwide.

Objective: We evaluated the immunological status of patients with gastric cancer before surgery and circulating cytokines as potential diagnostic biomarkers for gastric cancer.

Methods: We included 90 healthy controls and 95 patients with distal Gastric adenocarcinoma in Mazandaran, Sari, Iran. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-83DOI Listing

DIGESTIVE DISEASES IN ELDERLY AND FACTORS ASSOCIATED WITH LENGTH OF STAY IN THE HEPATOLOGY AND GASTROENTEROLOGY UNIT OF THE CAMPUS TEACHING HOSPITAL OF LOME (TOGO).

Arq Gastroenterol 2018 Oct-Dec;55(4):369-374

Hepatology and Gastroenterology Unit of the Campus Teaching Hospital of Lome, Togo.

Background: The digestive pathologies are frequent in the elderly and often have a latent and atypical symptomatology.

Objective: To assess the epidemiological and evolutionary current data on digestive diseases in the elderly, and look for factors associated with length of hospital stay.

Methods: Retrospective study of 10 years, including patients aged 60 and over hospitalized for digestive diseases in the Gastroenterology Department of the Campus Teaching Hospital of Lome, Togo. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-80DOI Listing

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis.

Authors:
Fan Zhang Cuimei Ma

Braz J Med Biol Res 2019 Feb 14;52(2):e7843. Epub 2019 Feb 14.

Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining, China.

Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Read More

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http://dx.doi.org/10.1590/1414-431X20187843DOI Listing
February 2019

Potentiation of In Vivo Anticancer Efficacy of Selenium Nanoparticles by Mushroom Polysaccharides Surface Decoration.

J Agric Food Chem 2019 Feb 20. Epub 2019 Feb 20.

Selenium nanoparticles (SeNPs) are recently emerging as promising anticancer agents because of their high bioavailability, low toxicity and remarkable anticancer activities. However, the effects of surface physicochemical properties on the biological actions remain elusive. Herein we decorated selenium nanoparticles (SeNPs) with various water-soluble polysaccharides extracted from various mushrooms, to compare physical characteristics and anticancer profile of these SeNPs. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00193DOI Listing
February 2019

Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta-analysis.

Mol Genet Genomic Med 2019 Feb 19:e589. Epub 2019 Feb 19.

Department of Gastroenterology, Linyi Central Hospital, Linyi, China.

Background: The relationship between phospholipase C ε-1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta-analysis to obtain a more credible conclusion.

Methods: PubMed, Medline, and Embase were systematic searched. Read More

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http://dx.doi.org/10.1002/mgg3.589DOI Listing
February 2019

Current information on the association of Helicobacter pylori with autophagy and gastric cancer.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Microbiology, Fasa University of Medical Sciences, Fasa, Iran.

Helicobacter pylori (H. pylori) is a Gram-negative bacterium and causative agent of gastric cancer. H. Read More

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http://doi.wiley.com/10.1002/jcp.28279
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http://dx.doi.org/10.1002/jcp.28279DOI Listing
February 2019
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Helicobacter pylori infection and gastric cancer biology: tempering a double-edged sword.

Cell Mol Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527, Athens, Greece.

Helicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Read More

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http://link.springer.com/10.1007/s00018-019-03044-1
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http://dx.doi.org/10.1007/s00018-019-03044-1DOI Listing
February 2019
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