130,015 results match your criteria Gastric Cancer


Pre-operative laparoscopic staging of gastric cancer in patients who are candidates for neo-adjuvant chemotherapy: A Cross Sectional Study.

Biomol Concepts 2019 Apr 16;10(1):68-72. Epub 2019 Apr 16.

General Physician, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective The aim of this study is to evaluate the laparoscopic method in gastric cancer staging before surgery in patients undergoing Neo-adjuvant chemotherapy. Methods This was a cross-sectional study on patients with T3-T4 and node positive non-metastatic gastric adenocarcinoma who was candidates for neo-adjuvant chemotherapy. The patients were excluded from the study when they were not in the condition to continue the study. Read More

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http://dx.doi.org/10.1515/bmc-2019-0008DOI Listing

High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration.

Biomed Pharmacother 2019 Apr 18;115:108867. Epub 2019 Apr 18.

Institute of Diagnostics, School of Medicine, Shandong University, Ji'nan, Shandong, China. Electronic address:

Homeobox-containing 1 (HMBOX1) has been reported to be associated with biological characteristics of some tumors, but its roles in gastric cancer have never been reported. In the present study, we found that HMBOX1 expression was significantly upregulated in gastric cancer tissues and cell lines and correlated with the TNM stage, lymph-node metastatic and the overall survival (OS) of patients of gastric cancer. The overexpression of HMBOX1 in gastric cancer cells enhanced cell proliferation by accelerating cell cycle, induced cell migration. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108867DOI Listing

Long term outcome after minimally invasive and open Warshaw and Kimura techniques for spleen-preserving distal pancreatectomy: International multicenter retrospective study.

Eur J Surg Oncol 2019 Apr 8. Epub 2019 Apr 8.

General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona Hospital, Verona, Italy. Electronic address:

Background: The Warshaw (WT) and the Kimura (KT) techniques are both used for open or minimally invasive (MI) spleen preserving distal pancreatectomy (SPDP). Multicenter studies on long-term outcome of WT and KT are lacking.

Methods: Multicenter retrospective study with transversal follow-up moment, including patients who underwent SPDP from 2000 to 2017 at three high-volume centers in Italy and the Netherlands. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.04.004DOI Listing

Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis.

J Surg Res 2019 Apr 17;241:31-39. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193015
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http://dx.doi.org/10.1016/j.jss.2019.03.036DOI Listing
April 2019
1 Read

Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

The B cell lymphoma 2 (BCL2) family of proteins constitutes a critical intracellular checkpoint in the intrinsic apoptosis pathway. Among BCL2 members, the anti-apoptotic protein BCL2A1 mediates the resistance to BCL2 inhibitors and may be considered as a target for anti-cancer therapy. Here, we report that prenylated Rab acceptor 1 (RABAC1 or PRA1) inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in AGS gastric cancer cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193071
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http://dx.doi.org/10.1016/j.bbrc.2019.04.080DOI Listing
April 2019
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The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.

Alcohol 2019 Apr 16. Epub 2019 Apr 16.

Division of Endocrine and Metabolic Disease, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, 28159, South Korea.

Background: Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and wide range of negative health consequences from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics. Read More

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http://dx.doi.org/10.1016/j.alcohol.2019.03.004DOI Listing

Long non‑coding RNA RP1‑163G9.1 is downregulated in gastric adenocarcinoma and is associated with a poor prognosis.

Oncol Rep 2019 Apr 17. Epub 2019 Apr 17.

The School of Basic Medical Sciences, Fujian Medical University, Minhou, Fuzhou, Fujian 350108, P.R. China.

The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9. Read More

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http://dx.doi.org/10.3892/or.2019.7127DOI Listing

[Corrigendum] Increased expression of Lgr5 is associated with chemotherapy resistance in human gastric cancer.

Oncol Rep 2019 Apr 16. Epub 2019 Apr 16.

Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.

An interested reader drew to the attention of the Journal that the western blot featured in Fig. 3B of the above paper also appeared as Fig. 3D in the following publication, featuring many of the same authors: Xi HQ, Cai AZ, Wu XS et al: Leucine‑rich repeat‑containing G‑protein‑coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer. Read More

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http://dx.doi.org/10.3892/or.2019.7120DOI Listing

Differential expression of tescalcin by modification of promoter methylation controls cell survival in gastric cancer cells.

Oncol Rep 2019 Apr 4. Epub 2019 Apr 4.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34824, Republic of Korea.

The EF‑hand calcium binding protein tescalcin (TESC) is highly expressed in various human and mouse cancer tissues and is therefore considered a potential oncogene. However, the underlying mechanism that governs TESC expression remains unclear. Emerging evidence suggests that TESC expression is under epigenetic regulation. Read More

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http://dx.doi.org/10.3892/or.2019.7099DOI Listing

Clinicopathological and prognostic significance of miR-4317 expression in gastric cancer patients.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2803-2808

Department of Gastroenterology, Jining No. 1 People's Hospital Affiliated to Jining Medical University, Jining, Shandong, China.

Objective: Previous studies have revealed that miR-4317 was abnormally expressed and functioned as a tumor suppressor in several tumors, including gastric cancer (GC). However, the clinical significance of miR-4317 in GC remains largely unclear. Our present study aimed at investigating the possibility of miR-4317 as a novel prognostic biomarker for GC patients. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17555DOI Listing

LncRNA DANCR accelerates the development of multidrug resistance of gastric cancer.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2794-2802

Sterilized Supplying Center, Yantai Yuhuangding Hospital, Yantai, China.

Objective: The development of multidrug resistance (MDR) is a key issue for tumor recurrence and metastasis, leading to treatment failure of gastric cancer (GC). Long non-coding RNA (lncRNA) DANCR has been shown to be highly expressed in GC patients, which accelerates growth and metastasis of GC cells. This study aims to elucidate the role of DANCR in regulating MDR of GC. Read More

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http://www.europeanreview.org/article/17554
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http://dx.doi.org/10.26355/eurrev_201904_17554DOI Listing
April 2019
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Remnant Gastric Cancer After Roux-en-Y Gastric Bypass: Narrative Review of the Literature.

Obes Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Biomedical Science for Health, Division of General Surgery Istitituto Clinico Sant'Ambrogio, University of Milan, Milan, Italy.

Background: The Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed procedures for surgical weight loss. It has been shown that overweight may be associated with an increased risk of gastric cancer. However, the risk of remnant gastric cancer after RYGB has not been defined yet and the development of neoplasm in the excluded stomach remains a matter of concern. Read More

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http://link.springer.com/10.1007/s11695-019-03892-7
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http://dx.doi.org/10.1007/s11695-019-03892-7DOI Listing
April 2019
1 Read

Laparoscopic completion gastrectomy in elderly patients with remnant gastric cancer: a case series.

Surg Case Rep 2019 Apr 17;5(1):63. Epub 2019 Apr 17.

Department of Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1, Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa, 230-8765, Japan.

Background: Open completion gastrectomy (OCG) has been selected to treat remnant gastric cancer (RGC) due to severe adhesions and difficulty recognizing anatomical orientation after primary gastrectomy. In general, elderly individuals' physiological reserves gradually decrease. Moreover, elderly patients (EPs) often have multiple complicating factors (i. Read More

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http://dx.doi.org/10.1186/s40792-019-0610-0DOI Listing

Pyruvate kinase M2 contributes to cell growth in gastric cancer via aerobic glycolysis.

Pathol Res Pract 2019 Apr 7. Epub 2019 Apr 7.

Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital/Institute, Beijing, 100142, China. Electronic address:

Pyruvate kinase M2 (PKM2) serves as a key enzyme that promotes aerobic glycolysis. This study investigated the function of PKM2 in tumor growth and maintenance in gastric cancer (GC). Histological staining was applied to detect PKM2 expression in GC tissues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338193002
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http://dx.doi.org/10.1016/j.prp.2019.04.001DOI Listing
April 2019
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Long non-coding RNA ZFAS1 regulates the malignant progression of gastric cancer via the microRNA-200b-3p/Wnt1 axis.

Biosci Biotechnol Biochem 2019 Apr 18:1-11. Epub 2019 Apr 18.

a Department of Gastroenterology , The First Hospital of Jilin University , Changchun , People's Republic of China.

Gastric cancer is a common malignant tumor. Studies from our laboratory or others have shown that long non-coding RNA (lncRNA) zinc finger antisense (ZFAS)1 often acts as an oncogene. However, the molecular underpinnings of how ZFAS1 regulates gastric cancer remain to be elucidated. Read More

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http://dx.doi.org/10.1080/09168451.2019.1606697DOI Listing

Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing

Timing of Adjuvant Chemotherapy and Survival in Colorectal, Gastric, and Pancreatic Cancer. A Systematic Review and Meta-Analysis.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Oncology Unit, ASST Cremona, 26100 Cremona, Italy.

(1) Background: The optimal timing of adjuvant chemotherapy (CT) in gastrointestinal malignancies is still a matter of debate. For colorectal cancer, it is recommended to start post-operative treatment within eight weeks. The objective of this study was to assess the clinical effects of starting adjuvant CT within or after 6-8 weeks post-surgery in colorectal, gastric, and pancreatic cancer. Read More

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https://www.mdpi.com/2072-6694/11/4/550
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http://dx.doi.org/10.3390/cancers11040550DOI Listing
April 2019
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Novel Insights of Lymphomagenesis of -Dependent Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Cancer Research Center, National Taiwan University College of Medicine, Taipei 100, Taiwan.

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the most common subtype of gastric lymphoma. Most gastric MALT lymphomas are characterized by their association with the (HP) infection and are cured by first-line HP eradication therapy (HPE). Several studies have been conducted to investigate why most gastric MALT lymphomas remain localized, are dependent on HP infection, and show HP-specific intratumoral T-cells (e. Read More

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http://dx.doi.org/10.3390/cancers11040547DOI Listing

Early Gastric Cancer: Current Limitations and What Can Be Done to Address Them.

Am J Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine, Universidad de La Sabana, Bogotá DC, Colombia.

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http://dx.doi.org/10.14309/ajg.0000000000000220DOI Listing
April 2019
2 Reads

Evaluation of sarcopenia, sarcopenic obesity, and phase angle in geriatric gastrointestinal cancer patients: before and after chemotherapy

Turk J Med Sci 2019 Apr 18;49(2):583-588. Epub 2019 Apr 18.

Background/aim: The purpose of this study was to determine sarcopenia, sarcopenic obesity and phase angle (PA) and the influence of chemotherapy (CT) on anthropometric measurements and and the PA in in geriatric patients with gastrointestinal (GI) cancer.

Materials And Methods: The anthropometric measurements, calf circumference (CC), upper midarm circumference (UMAC), and hand grip strength (HGS), have been measured to understand muscle function of 153 patients (mean age of 70.5 ± 5. Read More

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http://dx.doi.org/10.3906/sag-1808-114DOI Listing
April 2019
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One-step validation method for surrogate endpoints using data from multiple randomized cancer clinical trials with failure-time endpoints.

Stat Med 2019 Apr 17. Epub 2019 Apr 17.

INSERM U1219 (Biostatistic), Université Bordeaux Segalen, Bordeaux, France.

A surrogate endpoint can be used instead of the most relevant clinical endpoint to assess the efficiency of a new treatment. Before being used, a surrogate endpoint must be validated based on appropriate methods. Numerous validation approaches have been proposed with the most popular used in a context of meta-analysis, based on a two-step analysis strategy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.8162
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http://dx.doi.org/10.1002/sim.8162DOI Listing
April 2019
4 Reads

Comprehensive Analysis of the Canonical and Non-canonical Wnt Signaling Pathways in Gastric Cancer.

Dig Dis Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Otolaryngology, Xi'an No.4 Hospital, No. 21 Jiefang Road, Xi'an, 710004, Shaanxi, China.

Background: Previous studies showed that dysregulation of Wnt signaling by gene mutation and abnormal gene expression is one of the causative factors for gastric cancer (GC). So far, a systematic and comprehensive analysis of gene mutation, gene expression, and DNA methylation profiles of the Wnt pathway associated with gastric carcinogenesis, however, has not yet been reported.

Aims: To this end, we investigated all the above-mentioned genetic alterations associated with the canonical and non-canonical Wnt pathways in GC tumors, in order to understand the molecular mechanism underlying gastric carcinogenesis. Read More

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http://dx.doi.org/10.1007/s10620-019-05606-6DOI Listing
April 2019
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A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking.

Int J Legal Med 2019 Apr 17. Epub 2019 Apr 17.

INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism and Cancer), University Rennes, 35000, Rennes, France.

Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Read More

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http://link.springer.com/10.1007/s00414-019-02062-9
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http://dx.doi.org/10.1007/s00414-019-02062-9DOI Listing
April 2019
2 Reads

Routine placement of feeding jejunostomy tube during esophagectomy increases postoperative complications and does not improve postoperative malnutrition.

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan.

Esophagectomy for esophageal cancer is a highly invasive procedure, and a feeding jejunostomy tube (FJT) is routinely placed to ensure adequate enteral nutrition. However, the effect of perioperative short-term FJT placement remains controversial, and the aim of this study was to assess risks and benefits of routine FJT placement during esophagectomy and to determine parameters that can identify patients needing long-term FJT. This retrospective study included 393 patients who had undergone esophagectomy with gastric tube reconstruction via the posterior mediastinal route at the Kobe University Hospital and the Hyogo Cancer Center between April 2010 and December 2017. Read More

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http://dx.doi.org/10.1093/dote/doz021DOI Listing
April 2019
1 Read

Immuno-checkpoint inhibitors in metastatic esophago-gastric cancer.

J Thorac Dis 2019 Mar;11(Suppl 3):S376-S380

Oncology and Onco-hematology Department, Ospedale Regionale Umberto Parini, Aosta, Italy.

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http://dx.doi.org/10.21037/jtd.2018.12.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424743PMC

Haemostasis treatment using dual red imaging during endoscopic submucosal dissection: a multicentre, open-label, randomised controlled trial.

BMJ Open Gastroenterol 2019 30;6(1):e000275. Epub 2019 Mar 30.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan.

Introduction: Patients scheduled to undergo oesophageal, gastric and colorectal endoscopic submucosal dissection (ESD) are to be investigated to verify the efficacy of dual red imaging (DRI) for establishing haemostasis during ESD.

Methods And Analysis: The trial is designed as a multicentre, open-label randomised, parallel-group, controlled intervention study. Registered patients will be randomly assigned to DRI and white light imaging (WLI) groups. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441255PMC
March 2019
1 Read

A remarkable clinical response in advanced gastric cancer treated with trastuzumab plus capecitabine combination chemotherapy: A report of two cases.

Clin Case Rep 2019 Apr 26;7(4):714-718. Epub 2019 Feb 26.

Department of Surgical Oncology Kanazawa Medical University Hospital Uchinada, Kahoku Japan.

When trastuzumab + capecitabine and cisplatin chemotherapy could not be conducted continuously because of severe adverse reactions to cisplatin, trastuzumab + capecitabine could be an alternative systemic chemotherapy options for metastatic or recurrent gastric cancer patients. Read More

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http://dx.doi.org/10.1002/ccr3.2056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452495PMC

First-of-its-kind STARD Inhibitor: Identification and Biological Evaluation as Anticancer Agent.

ACS Med Chem Lett 2019 Apr 20;10(4):475-480. Epub 2019 Feb 20.

Department of Translational Research, Pathology Unit, National Cancer Institute-CRO-IRCSS, 33081 Aviano, Italy.

STARD3 is a cellular protein that represents an attractive target for cancer therapy, being overexpressed in breast cancer and implied in the development of colorectal, gastric, and prostate cancers. Unfortunately, no STARD3 inhibitor has been identified yet. In this work, an strategy was applied to predict a reliable binding mode of cholesterol into STARD3 and to develop a pharmacophore-based virtual screening protocol that allowed the identification of the first STARD3 inhibitor ever reported. Read More

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00509
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http://dx.doi.org/10.1021/acsmedchemlett.8b00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466518PMC
April 2019
2 Reads

Risk-stratification model to select conversion surgery for advanced gastric cancer patients.

Chin J Cancer Res 2019 Feb;31(1):178-187

Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

Objective: Conversion surgery is a surgery with a purpose of R0 resection in primary advanced gastric cancer (GC) that responded well to systemic chemotherapy. This study aimed to explore the efficacy of conversion surgery for advanced GC.

Methods: A total of 618 advanced GC patients receiving systemic chemotherapy were stratified into low-, moderate- and high-risk groups based on a nomogram-predicted probability of overall survival. Read More

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http://article.cjcrcn.org/en/article/doi/10.21147/j.issn.100
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http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433581PMC
February 2019
1 Read

Metastatic patterns and surgical methods for lymph nodes No. 5 and No. 6 in proximal gastric cancer.

Chin J Cancer Res 2019 Feb;31(1):171-177

Department of Surgical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.

Objective: The current surgical treatment guidelines for early proximal gastric cancer (PGC) still lack agreement. Lymphadenectomy of lymph nodes No. 5 and No. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433591PMC
February 2019
1 Read

[Characteristics analysis of early gastric cancer under white light endoscopy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):302-306

Department of gastroenterology,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate endoscopic features of early gastric cancer and clinical features of the patients, which may be helpful to provide reasonable suggestions for physicians to diagnose early gastric cancer during preliminary screening of white light gastroscopy.

Methods: A total of 271 patients who received endoscopic submucosal dissection or surgical operation to confirm early gastric cancer in Peking University Third Hospital from Apr. 2009 to Jun. Read More

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April 2019
2 Reads

Clinical usefulness of ramucirumab plus paclitaxel for unresectable and recurrent gastric cancer.

Fukushima J Med Sci 2019 ;65(1):6-12

Department of Gastrointestinal Tract Surgery Fukushima Medical University.

Introduction Recently in Japan, Ramucirumab (RAM) became the first anti-angiogenic agent to be approved for second-line treatment of gastric cancer. In the present study, we aimed to evaluate the efficacy and safety of RAM plus paclitaxel (PTX) in patients with unresectable and recurrent gastric cancer in our institution.Patients and Methods The subjects were 11 patients with unresectable and recurrent gastric cancer who received RAM plus PTX as a second- or later-line treatment at our hospital between June 2015 and September 2017, after the failure of previously-attempted treatments. Read More

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http://dx.doi.org/10.5387/fms.2018-12DOI Listing
January 2019
1 Read

Temperature-responsive biometamaterials for gastrointestinal applications.

Sci Transl Med 2019 Apr;11(488)

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm water ingestion) and extra-esophageal (protected from ingestion of warm liquids and actuatable by endoscopically administered warm fluids). Inspired by a blooming flower, we developed a capsule-sized esophageal system that deploys using elastomeric elements and then recovers its original shape in response to thermal triggering of shape-memory nitinol springs by ingestion of warm water. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau8581DOI Listing
April 2019
2 Reads

Underwater endoscopic mucosal resection for remaining early gastric cancer after endoscopic submucosal dissection.

Endoscopy 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

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http://dx.doi.org/10.1055/a-0875-3429DOI Listing
April 2019
1 Read

Selective colony area method for heterogeneous patient-derived tumor cell lines in anti-cancer drug screening system.

PLoS One 2019 17;14(4):e0215080. Epub 2019 Apr 17.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We aimed to establish a fluorescence intensity-based colony area sweeping method by selecting the area of highest viability among patient-derived cancer cells (PDC) which has high tumor heterogeneity. Five gastric cancer cell lines and PDCs were screened with 24 small molecule compounds using a 3D micropillar/microwell chip. 100 tumor cells per well were immobilized in alginate, treated with the compounds, and then stained and scanned for viable cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215080PLOS
April 2019
2 Reads

Rebamipide solution as a submucosal injection material for possible prevention of gastric stenosis after endoscopic submucosal dissection.

Dig Endosc 2019 Apr;31 Suppl 1:22-23

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/den.13351
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http://dx.doi.org/10.1111/den.13351DOI Listing
April 2019
1 Read

Management of adverse events related to endoscopic resection of esophageal and gastric neoplasms: Report of consensus meeting.

Dig Endosc 2019 Apr;31 Suppl 1:2-3

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

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http://dx.doi.org/10.1111/den.13386DOI Listing
April 2019
1 Read

Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.

Dig Endosc 2019 Apr;31 Suppl 1:4-20

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Prevention therapy is recommended for lesions >1/2 of the esophageal circumference. Locoregional steroid injection is recommended for lesions >1/2-3/4 of the esophageal circumference and oral steroids are recommended for lesions >1/2 of the subtotal circumference. For lesions of the entire circumference, oral steroid combined with injection steroid is considered. Read More

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http://dx.doi.org/10.1111/den.13388DOI Listing
April 2019
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Dynamic Contrast-Enhanced Ultrasound of Gastric Cancer: Correlation with Perfusion CT and Histopathology.

Korean J Radiol 2019 May;20(5):781-790

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objective: To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features.

Materials And Methods: This prospective study was approved by our Institutional Review Board. We included 43 patients with pathologically-proven gastric cancers undergoing CEUS using SonoVue® (Bracco) and PCT on the same day. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2018.02
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http://dx.doi.org/10.3348/kjr.2018.0273DOI Listing
May 2019
3 Reads

Long-term outcomes of superficial neoplasia at the esophagogastric junction treated via endoscopic submucosal dissection and endoscopic submucosal tunnel dissection: a cohort study of a single center from China.

Surg Endosc 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.

Background And Aims: The techniques and indications for endoscopic submucosal dissection (ESD) and endoscopic submucosal tunnel dissection (ESTD) to remove superficial neoplasia at the esophagogastric junction (EGJ) have been developed and expanded. However, the resection of superficial neoplasia at the EGJ by ESD remains challenging, and the long-term clinical outcomes of curative and non-curative resections based on histological criteria remain unclear. We conducted a retrospective analysis on the safety and efficacy of the ESD and ESTD procedure with these patients. Read More

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http://dx.doi.org/10.1007/s00464-019-06753-7DOI Listing
April 2019
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Significance of Intramural Metastasis in Patients with Esophageal Squamous Cell Carcinoma: An Indicator of Aggressive Cancer Behavior.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Intramural metastasis (IM) is occasionally noted in patients with esophageal squamous cell carcinoma (ESCC). However, few recent studies have investigated the clinicopathological characteristics of IM and its survival impact. The present study aimed to clarify the clinicopathological and prognostic significance of IM in patients with ESCC. Read More

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http://dx.doi.org/10.1007/s00268-019-05004-zDOI Listing
April 2019
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Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer.

Chronic Dis Transl Med 2019 Mar 23;5(1):44-52. Epub 2018 Oct 23.

Department of Oncology, Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, Henan 450008, China.

Objective: To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment.

Methods: The Cancer Genome Atlas (TCGA) stomach adenocarcinoma sequencing data were used to predict genes co-expressed with cyclin E. Co-expression genes predicted by cBioPortal online analysis with Pearson correlation coefficient ≥0. Read More

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http://dx.doi.org/10.1016/j.cdtm.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449734PMC

Tandem repeats of the 5' flanking region of human have a role as a novel enhancer in gene expression.

Biochem Biophys Rep 2019 Jul 4;18:100632. Epub 2019 Apr 4.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. However, the molecular mechanism of regulation of expression remains to be elucidated. In previous studies, we have shown that Gli regulated transcription through the Gli-binding motif in the 5' region of . Read More

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http://dx.doi.org/10.1016/j.bbrep.2019.100632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449733PMC
July 2019
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Astaxanthin Prevents Decreases in Superoxide Dismutase 2 Level and Superoxide Dismutase Activity in -infected Gastric Epithelial Cells.

J Cancer Prev 2019 Mar 30;24(1):54-58. Epub 2019 Mar 30.

Department of Food and Nutrition, Brian Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.

Background: increases production of reactive oxygen species (ROS), which activates inflammatory and carcinogenesis-related signaling pathways in gastric epithelial cells. Therefore, reducing ROS, by upregulating antioxidant enzyme, such as superoxide dismutase (SOD), may be a novel strategy to prevent -associated gastric diseases. Astaxanthin is an antioxidant carotenoid that prevents oxidative stress-induced cell injury. Read More

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http://dx.doi.org/10.15430/JCP.2019.24.1.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453584PMC

The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components.

J Oncol 2019 12;2019:3671268. Epub 2019 Mar 12.

Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice. Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent.

Methods: We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component. Read More

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https://www.hindawi.com/journals/jo/2019/3671268/
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http://dx.doi.org/10.1155/2019/3671268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434268PMC
March 2019
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Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases.

Int J Endocrinol 2019 12;2019:9871319. Epub 2019 Mar 12.

Division of General Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, USA.

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly present with metastatic disease, and the liver is the most frequent metastatic site. Herein, we studied whether primary tumor site affects survival in patients with GEP-NETs and liver metastases (NELM). As a secondary endpoint, we studied whether extrahepatic disease and surgical resection impact survival in this patient population. Read More

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https://www.hindawi.com/journals/ije/2019/9871319/
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http://dx.doi.org/10.1155/2019/9871319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434277PMC
March 2019
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1,25-Dihydroxyvitamin D affects gastric cancer progression by repressing BMP3 promoter methylation.

Onco Targets Ther 2019 28;12:2343-2353. Epub 2019 Mar 28.

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211800, People's Republic of China,

Background: Vitamin D has been known to have an anticancer effect, but the mechanisms underlying this is poorly explored. The present study aimed to investigate the antitumor role of vitamin D on gastric cancer and mechanisms.

Methods: The Roche Elecsys platform was applied in retrospective studies to detect the role of 25-hydroxylvitamin D in adenocarcinoma and colony formation assay was conducted to verify the effect of 1, 25-dihydroxyvitamin D on the proliferation of gastric cancer cells. Read More

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http://dx.doi.org/10.2147/OTT.S195642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445188PMC

NT5E is associated with unfavorable prognosis and regulates cell proliferation and motility in gastric cancer.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Qilu Hospital of Shandong University, Jinan, China.

Ecto-5'-nucleotidase (NT5E) is a glycosylphosphatidylinositol anchored cell surface protein, and has been suggested to be dysregulated in most types of human cancer including gastric cancer. The aim of this study was to present more evidence about the clinical and prognostic value of Ecto-5'-nucleotidase in gastric cancer patients, and preliminarily explore the biological function of Ecto-5'-nucleotidase in gastric cancer cells. In our study, high Ecto-5'-nucleotidase expression was observed in gastric cancer tissues and cell lines respectively compared to normal gastric mucosa tissues cells. Read More

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http://dx.doi.org/10.1042/BSR20190101DOI Listing

Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites.

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

The CANHelp Working Group, University of Alberta, Edmonton, AB T6G 2E1, Canada.

In northern Canada where there is a high prevalence of infection, there is a paucity of information on gastric cancer by the topographical subsites cardia (CGC) and non-cardia (NCGC). Here we describe the incidence of CGC and NCGC, separately, among northern Canadian populations. We used data from the Cancer Incidence in Five Continents Volumes X (CI5X) and XI (CI5XI) to obtain CGC and NCGC incidence for Canada and for Yukon (YT), a northern Canadian territory. Read More

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http://dx.doi.org/10.3390/cancers11040534DOI Listing

Spasmolytic polypeptide-expressing metaplasia associated with higher expressions of miR-21, 155, and 223 can be regressed by Helicobacter pylori eradication in the gastric cancer familial relatives.

Helicobacter 2019 Apr 16:e12578. Epub 2019 Apr 16.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.

Background And Aims: Spasmolytic polypeptide-expressing metaplasia (SPEM) is a preneoplastic gastric cancer lesion related to epigenetic microRNA (miRNA) expression. This study elucidated whether Helicobacter pylori-infected first-degree relatives of patients with gastric cancer (GCF) are susceptible to have SPEM and correlated with miR-21, 155, and 223 expressions. We also validated whether SPEM and these miRNAs can be regressed after H pylori eradication. Read More

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http://dx.doi.org/10.1111/hel.12578DOI Listing
April 2019
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