Search Our Scientific Publications & Authors

Int J Surg Case Rep 2020 May 29;71:327-330. Epub 2020 May 29.

Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1 Aoyama, Kure City, Hiroshima, 737-0023, Japan; Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Introduction: We experienced an extremely rare case of gastric adenocarcinoma wrapped by leiomyoma.

Presentation Of Case: A 65-year-old man had an abnormality (filling defect) of the upper gastrointestinal series in his first medical checkup five years prior. Esophagogastroduodenoscopy detected a 10 mm submucosal tumor-like lesion in the greater curvature of the upper gastric remnant body. Read More

Int J Pharm 2020 May 31:119482. Epub 2020 May 31.

Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai-400076, India. Electronic address:

Chemotherapy in drug-resistant cancers remains a challenge. Owing to associated poor bioavailability, oral administration of hydrophobic anticancer drugs like paclitaxel has been quite challenging, with the scenario being further complicated by Pgp efflux in drug-resistant tumours. We developed a novel nanocochleates (CPT) system encapsulating paclitaxel (PTX) to treat resistant colon cancer by oral administration. Read More

J Ethnopharmacol 2020 May 31:112946. Epub 2020 May 31.

Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China. Electronic address:

Ethnopharmacological Relevance: Zanthoxylum nitidum (Roxb.) DC. (Z. Read More

Gen Comp Endocrinol 2020 May 31:113522. Epub 2020 May 31.

George Washington University of School of Medicine, 2300 I St NW, Washington, DC 20052, USA.

The crustacean hyperglycemic hormone (CHH) neuropeptide family has multiple functions in the regulation of hemolymph glucose levels, molting, ion, and water balance and reproduction. In crab species, three neuroendocrine tissues: the eyestalk ganglia (medulla terminalis X-organ and -sinus gland= ES), the pericardial organ (PO), and guts synthesize a tissue-specific isoforms of CHH neuropeptides. Recently the presence of the mandibular organ-inhibiting hormone (MOIH) was reported in the stomatogastric nervous system (STNS) that regulates the rhythmic muscle movements in esophagus, cardiac sac, gastric and pyloric ports of the foregut. Read More

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Centre for Gastric Cancer.

Background: Sentinel node navigation surgery reduces the extent of gastric and lymph node dissection, and may improve quality of life. The benefit and harm of laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer is unknown. The SENORITA (SEntinel Node ORIented Tailored Approach) trial investigated the pathological and surgical outcomes of LSNNS compared with laparoscopic standard gastrectomy (LSG) with lymph node dissection. Read More

Ann Gastroenterol Surg 2020 May 25;4(3):275-282. Epub 2020 Mar 25.

Department of Surgery School of Medicine Toho University Tokyo Japan.

Background And Aim: We evaluated the clinicopathological and prognostic significance of serum p53 (s-p53-Abs) and serum NY-ESO-1 autoantibodies (s-NY-ESO-1-Abs) in esophageal squamous cell carcinoma (ESCC), gastric cancer and hepatocellular carcinoma (HCC).

Patients And Methods: A total of 377 patients, 85 patients with ESCC, 248 patients with gastric cancer, and 44 patients with HCC were enrolled to measure s-p53-Abs and s-NY-ESO-1-Abs titers by the enzyme-linked immunosorbent assay before treatment. The clinicopathological significance and prognostic impact of the presence of autoantibodies were evaluated. Read More

Respir Med Case Rep 2020 23;30:101104. Epub 2020 May 23.

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Most metastatic lung tumors display well-defined, round, multiple nodular shadows, whereas the presence of diffuse ground-glass opacities on chest computed tomography generally suggests non-malignant conditions. Here, we report an unusual case of pulmonary metastasis from gastric cancer in which diffuse ground-glass opacities were observed in all lung segments. A 59-year-old man with a 3-month history of worsening chest pain and shortness of breath was referred to the pulmonary clinic. Read More

J Cancer 2020 18;11(15):4421-4430. Epub 2020 May 18.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

: A consensus regarding optimum treatment strategies for locally advanced gastric cancer (LAGC) has not yet been reached. We aimed to evaluate the efficacy of various treatment modalities for LAGC and provided clinicians salvage options under real-world situation. : Medical charts of patients with LAGC who underwent radical resection plus adjuvant chemotherapy or chemoradiotherapy from July 2003 to December 2014 were included. Read More

J Cancer 2020 27;11(15):4352-4365. Epub 2020 Apr 27.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

DNA methylation has been reported to serve an important role in the carcinogenesis and development of gastric cancer. Our aim was to systematically develop an individualized prediction model of the survival risk combing clinical and methylation factors in gastric cancer. A univariate Cox proportional risk regression analysis was used to identify the prognosis-associated methylation sites based on the differentially expressed methylation sites between early and advanced gastric cancer group, then we applied least absolute shrinkage and selection operator (LASSO) Cox regression model to screen candidate methylation sites. Read More

J Cancer 2020 27;11(15):4332-4342. Epub 2020 Apr 27.

Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Esophagogastric junction cancer poses a great threat to human beings both in western countries and East Asia, especially in China and Japan, and its incidence has increased during recent decades. The 5-year survival rate of esophagogastric junction cancer is quite poor compared with that of other gastric cancer sites. Until now, the traditional TNM staging system has been widely used in clinical practice for prognosis. Read More

Cancer Cell Int 2020 24;20:188. Epub 2020 May 24.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013 China.

Background: The stem cell factor SALL4 is reactivated in human cancers. SALL4 plays diverse roles in tumor growth, metastasis, and drug resistance, but its role in tumor metabolism has not been well characterized.

Methods: The glycolytic levels of gastric cancer cells were detected by glucose uptake, lactate production, lactate dehydrogenase activity, ATP level, and hexokinase activity. Read More

Cancer Cell Int 2020 24;20:186. Epub 2020 May 24.

Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032 China.

Background: Programmed death-ligand 1 (PD-L1) expression determines the eligibility for anti-PD-1 treatment in patients with advanced gastric cancer, but evidence indicates that PD-L1 staining is heterogeneous. Patients who are ineligible for radical surgery could be tested for PD-L1 expression with biopsy staining, but it is unclear if a small biopsy is representative of the PD-L1 status of the whole tumor. The aim of our study was to determine how many biopsy specimens are needed to accurately reflect the objective status of PD-L1 expression in whole sections. Read More

Curr Oncol 2020 Apr 1;27(2):e182-e190. Epub 2020 May 1.

Sinai Health System, Department of Surgery, University of Toronto, Toronto, ON.

Background: pathogenic variants (pvs) cause most cases of inherited diffuse gastric cancer (dgc), but have low detection rates and vary geographically. In the present study, we examined hereditary causes of dgc in patients in Ontario.

Methods: testing through single-site or multi-gene panels was conducted for patients with dgc meeting the 2015 International Gastric Cancer Linkage Consortium (igclc) criteria, or with isolated dgc at less than 50 years of age, or with a strong family history of cancer identified at the Zane Cohen Centre (zcc). Read More

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820928072

Department of Gastroenterological Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: The aim of the study is to determine the role of nuclear receptor coactivator 2 in cell proliferation and invasion ability of gastric cancer cells and to explore its possible mechanisms.

Methods: Immunohistochemical staining was used to determine gene expression in gastric cancer. Western blotting was used to detect Wnt signal pathways-related protein expression. Read More

J Nat Prod 2020 Jun 3. Epub 2020 Jun 3.

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, People's Republic of China.

A new dihydrobenzofuran-phenyl acrylate hybrid, aspeterreurone A (), was obtained from the culture of the deep-sea-derived fungus CC-S06-18. The relative configuration of was elucidated by HSQMBC NMR, calculated NMR chemical shifts coupled with a statistical procedure (DP4+), and the absolute configuration was established by ECD calculations. exhibited cytotoxicities against the gastric cancer cell lines HGC27, MGC803, BGC823, and AGS, with minimal effects on normal gastric epithelial cell line GES-1. Read More

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(8):1779-1788

School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine Hefei 230012, China Anhui Province Key Laboratory of Chinese Medicinal Formula Hefei 230012, China.

To investigate the mechanism of Coptidis Rhizoma-Pinelliae Rhizoma in the treatment of gastric cancer based on syste-matic pharmacology and data mining. The chemical constituents of Coptidis Rhizoma and Pinelliae Rhizoma were obtained from Traditio-nal Chinese Medicine Systems Pharmacology Database(TCMSP) and Shanghai Institute of Organic Chemistry database of Chinese Academy of Sciences by data mining. Then the active ingredients were screened by ADME, and the targets of the active ingredients were predicted by chemometrics. Read More

Eur J Cancer Care (Engl) 2020 Jun 2:e13260. Epub 2020 Jun 2.

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Objective: The aim of the study was to find factors associated with overall survival (OS) and establish a nomogram predicting OS of patients with gastric cancer (GC) after D2R0 resection.

Methods: Demographic and clinicopathologic factors of patients with GC underwent D2R0 surgical resection were retrospectively collected from medical records, telephone interview or outpatient follow-up. To find factors significantly associated with OS, univariate and multivariate analyses were conducted. Read More

J Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Academic Surgery, Sarcoma, Melanoma and Rare Tumours Unit, The Royal Marsden Hospital, London, UK.

Background And Objectives: The aim of surgical treatment of gastrointestinal stromal tumors (GIST) is a microscopically complete resection. Initial indications for laparoscopic surgery were limited to smaller tumors, in favorable locations. Over time, indications for minimal invasive surgery (MIS) have expanded, however concerns remain when considering resection of larger GISTs. Read More

Clin Transl Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Oncology I, Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China.

Background: Currently, the role of adjuvant radiotherapy (RT) in the treatment of patients with intestinal-type gastric adenocarcinoma (IGA) has not been well established. This study aimed to elucidate the survival impact of RT on such patients.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was utilized to select eligible patients. Read More

Clin Transl Oncol 2020 Jun 1. Epub 2020 Jun 1.

Department of Gastroenterology, Infectious Diseases and Rheumatology. Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Introduction: The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). Read More

Bull Exp Biol Med 2020 Jun 2. Epub 2020 Jun 2.

N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia.

An association was found between reduced expression of miR-34a, miR-146a with both metastasis to regional lymph nodes (relative risk RR=10.50 and RR=5.25, respectively) and the development of distant metastases (RR=9. Read More

Gastric Cancer 2020 Jun 2. Epub 2020 Jun 2.

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, P. Debyelaan 25, 6229HX, Maastricht, The Netherlands.

Background: The literature on the prognostic relevance of signet-ring cell (SRC) histology in gastric cancer (GC) is controversial which is most likely related to inconsistent SRC classification based on haematoxylin-eosin staining. We hypothesised that mucin stains can consistently identify SRC-GC and predict GC patient outcome.

Methods: We performed a comprehensive literature review on mucin stains in SRC-GC and characterised the mucin expression in 851 Caucasian GC and 410 Asian GC using Alcian Blue (AB)-Periodic Acid-Schiff (PAS), MUC2 (intestinal-type mucin), and MUC5AC (gastric-type mucin). Read More

Gastric Cancer 2020 Jun 2. Epub 2020 Jun 2.

Division of Cancer Medicine, Department of Gastroenterological Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objectives: Interleukin-17A (IL-17A) is pro-inflammatory cytokine and acts as profibrotic factor in the fibrosis of various organs. Fibrosis tumor-like peritoneal dissemination of gastric cancer interferes with drug delivery and immune cell infiltration because of its high internal pressure. In this study, we examined the relationship between IL-17A and tissue fibrosis in peritoneal dissemination and elucidated the mechanism of fibrosis induced by IL-17A using human peritoneal mesothelial cells (HPMCs) and a mouse xenograft model. Read More

Surg Case Rep 2020 Jun 1;6(1):123. Epub 2020 Jun 1.

Department of Surgery, The Jikei University School of Medicine, 3-19-18 Nishi-shinbashi, Minato-ku, Tokyo, 105-8471, Japan.

Background: We encountered a case of marginal ulcer in the jejunum after distal gastrectomy with jejunal pouch interposition. However, it has not been reported and not confirmed the treatment. We chose truncal vagotomy, considering reduced morbidity and postoperative complications. Read More

Ann Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Background: The purpose of this study was to investigate clinical features, prognostic factors, and overall survival (OS) in surgical patients with gastric remnant cancer (GRC).

Methods: A retrospective analysis of patients with gastrectomy for pT1-4 gastric cancer between October 1972 and February 2014 at our institution was performed. Clinical characteristics were compared between patients with GRC and those with primary gastric cancer (PGC). Read More

Ann Surg Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, University of Florida College of Medicine, Jacksonville, FL, USA.

The increasing prevalence of morbid obesity in the United States has been accompanied by a concomitant rise in bariatric surgery to help combat the epidemic. The relationship between obesity and certain cancers, such as esophageal adenocarcinoma, is well established. The need for minimally invasive techniques to treat esophageal cancer in patients with previous bariatric surgery is growing and can present a unique surgical challenge. Read More

J Cancer Res Clin Oncol 2020 Jun 2. Epub 2020 Jun 2.

Key Laboratory of Zoonosis Research, Ministry of Education/Institute of Zoonosis, College of Veterinary Medicine, Double-First Class Discipline of Human-Animal Medicine, Jilin University, Xi An Da Lu 5333, Changchun, 130062, China.

Introduction: Cholecystokinin type 2 receptor (CCK2R), which mediates the action of gastrin and cholecystokinin (CCK), has been demonstrated to promote the proliferation of colorectal cancer (CRC). A number of studies showed that CCK2R overexpressed in gastric cancer and pancreatic cancer but few in CRC. The correlation between CCK2R expression and clinicopathological characteristics is also not clear. Read More

Surg Today 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.

Purpose: To identify the incidence of extraction site incisional hernia following gastrectomy for gastric cancer and its significant risk factors, including the subcutaneous fat area.

Methods: We reviewed data gathered prospectively on patients with gastric cancer, who underwent gastrectomy between 2008 and 2012 at Kyushu University Hospital, Fukuoka, Japan. The subcutaneous fat area (SFA) and visceral fat area (VFA) were measured using axial computed tomography at the level of the L4 and L3 transverse processes, and the L2-L3 intervertebral disc. Read More

Med Sci Monit 2020 Jun 3;26:e923444. Epub 2020 Jun 3.

Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China (mainland).

BACKGROUND MicroRNAs (miRNAs) are attracting substantial interest as promising noninvasive biomarkers for gastric cancer (GC). Our study aimed to identify circulating miRNAs that are potential noninvasive markers for precancerous lesions and early gastric cancers (EGCs). MATERIAL AND METHODS Plasma specimens were obtained from 58 gastritis subjects, 54 patients with precancerous lesions, and 38 EGC patients for study. Read More

Gastroenterol Nurs 2020 May/Jun;43(3):241-248

Kyung Eun Lee, PhD, RN, KOCN (Korean Oncology Certification Nurse), is Assistant Professor, Department of Nursing, Keimyung College University, Daegu, Republic of Korea. Kyung Hee Lim, PhD, RN, is Assistant Professor, College of Nursing, Keimyung University, Daegu, Republic of Korea.

Patients with Stage I gastric cancer experience decreased postgastrectomy quality of life (QoL) despite the excellent surgical outcomes. We need to find foundational data required to develop effective nursing care plans designed to improve their QoL. This study examined QoL of patients with Stage I gastric cancer over time following gastrectomy and the effects of QoL subdomains on the patients' overall QoL over time after surgery. Read More

Aging (Albany NY) 2020 Jun 2;12. Epub 2020 Jun 2.

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Read More

Anticancer Res 2020 Jun;40(6):3401-3410

Department of Surgery, Sant' Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Background/aim: In local staging of gastric adenocarcinoma CT is the modality of choice. Less frequently used in a few selected patients is echo-endoscopy. Aim of this study was to evaluate the accuracy of hydro-multidetector-computed tomography (hydro-MDCT) in the evaluation of gastric adenocarcinomas with subsequent surgical and histopathological correlation to select cases for echo-endoscopy. Read More

Anticancer Res 2020 Jun;40(6):3247-3254

Department of Medical Life Sciences, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Background/aim: 5-Fluorouracil (5-FU) is an anticancer drug commonly used to treat gastric cancer; however, continuous 5-FU chemotherapy causes drug resistance.

Materials And Methods: We established five sublines of 5-FU-resistant AGS gastric cancer cells to investigate changes that may have occurred in the development of 5-FU resistance. Drug resistance to other chemotherapeutic reagents, proliferation, cell-cycle changes, and wound healing ability were assessed for each subline. Read More

Anticancer Res 2020 Jun;40(6):3203-3208

Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

Background/aim: We aimed to evaluate the characteristics of gastric carcinoma with high excision repair cross complementing 1 (ERCC1) expression and the prognostic value of ERCC1 expression.

Materials And Methods: ERCC1 expression was evaluated by immunohistochemistry in 309 surgically resected gastric carcinoma specimens using a tissue microarray. Cancer-related survival was analysed using competing risk analysis. Read More

Anticancer Res 2020 Jun;40(6):3163-3167

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aim: Ultrasonically activated surgical devices (USADs) have become indispensable instruments for gastrointestinal surgery. In this study, we investigated the oncological safety of the use of USADs.

Materials And Methods: We harvested and cultivated the splashes and mist scattered from an USAD when cutting MKN45-derived cancer nodules. Read More

Cancer Discov 2020 Jun 2. Epub 2020 Jun 2.

Trastuzumab deruxtecan may be effective in solid cancers in addition to breast cancer. In a randomized phase II trial of HER2-positive gastric and gastroesophageal junction cancers, the agent significantly extended overall survival and progression-free survival compared with standard chemotherapy. It also elicited high response rates in phase II trials of HER2-mutant non-small cell lung cancer and HER2-positive colorectal cancer. Read More

An Bras Dermatol 2020 May 5. Epub 2020 May 5.

Department of Pathology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Cutaneous metastases are rare. They usually present as nodules or tumors. Diagnosis is based on histopathological examination and prognosis is unfavorable. Read More

BMC Cancer 2020 Jun 1;20(1):493. Epub 2020 Jun 1.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Numerous studies conducted over the past 30 years have pointed to the presence of Epstein-Barr virus (EBV) in gastric cancer samples. This study was aimed to provide a meta-analytic review of the prevalence of EBV in gastric cancer patients, and to clarify the relationship between EBV infection and gastric cancer.

Methods: A literature search was performed electronically using online databases for English language publications until July 1, 2019. Read More

Int J Surg Pathol 2020 Jun 2:1066896920928126. Epub 2020 Jun 2.

Washington University in St. Louis, MO, USA.

Pancreatic heterotopia is a well-described entity occurring at multiple abdominal sites, most commonly the stomach and small intestine. They can develop similar disease processes as the pancreas ranging from acute pancreatitis, cyst formation, or neoplasms, most commonly ductal adenocarcinoma. Neuroendocrine tumors (NETs) arising in pancreatic heterotopias are exceedingly rare with only 3 prior published cases. Read More

J Biol Regul Homeost Agents 2020 Mar-Apr;34(2):669-674

Department of Medical Function, Mudanjiang Medical University, Mudanjiang, China.

Minerva Med 2020 May 29. Epub 2020 May 29.

Department of General Surgery, Jingjiang People's Hospital, Jingjiang, China -

Background: We aimed at investigating microRNA-216a-5p expression in gastric cancer (GC) tissues and further exploring whether microRNA-216a-5p suppresses GC progression through interacting with TCTN1.

Methods: microRNA-216a-5p expression in 60 pairs of GC tissues and adjacent ones was studied by quantitative real-time polymerase chain reaction (qRT-PCR) analysis, and the relationship between microRNA-216a-5p and clinical indicators as wells as prognosis of GC patients was also analyzed. At the same time, qRT-PCR was conducted to further verify microRNA-216a-5p level in GC cells. Read More

Zhonghua Yi Xue Za Zhi 2020 Jun;100(21):1617-1622

Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the spectral CT-based radiomics in predicting preoperatively the lymph node metastasis (LNM) of advanced gastric cancer. From January 2014 to October 2018, the spectral CT imaging and clinical data of 196 gastric adenocarcinoma patients confirmed by pathology in the First Affiliated Hospital of Zhengzhou University were retrospectively enrolled (training set and test set were randomly divided according to the ratio of 1∶1). These 196 patients include143 males and 53 females, aged from 28 to 81 years, with an average age of (59±11) years, and were divided into nodular metastasis group and non-metastasis group according to clinicopathological data. Read More

Zhonghua Nei Ke Za Zhi 2020 Jun;59(6):485-488

Department of Rheumatology, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, China.

A 28-year-old man was admitted to the first medical center of Chinese People's Liberation Army General Hospital because of multiple myalgia and intramuscular nodules for more than 2 months. The patient complained of dysphagia, fever and weight loss 2 months ago. Magnetic resonance imaging and biopsy revealed nodular fasciitis. Read More

Cancers (Basel) 2020 May 30;12(6). Epub 2020 May 30.

Severance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.

Despite recent innovations and advances in early diagnosis, the prognosis of advanced gastric cancer remains poor due to a limited number of available therapeutics. Here, we employed pharmacogenomic analysis of 37 gastric cancer cell lines and 1345 small-molecule pharmacological compounds to investigate biomarkers predictive of cytotoxicity among gastric cancer cells to the tested drugs. We discovered that expression of , encoding cyclin A2, was commonly associated with responses to polo-like kinase 1 (PLK1) inhibitors (BI-2536 and volasertib). Read More

Int J Mol Sci 2020 May 30;21(11). Epub 2020 May 30.

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne VIC 3000, Australia.

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeostasis. Wnt signaling controls several fundamental cell functions, including proliferation, differentiation, migration, and stemness. It therefore plays an important role in the epithelial homeostasis and regeneration of the gastrointestinal tract. Read More

Int J Mol Sci 2020 May 29;21(11). Epub 2020 May 29.

Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.

is a stomach pathogen that persistently colonizes the gastric mucosa, often leading to chronic inflammation and gastric pathologies. Although infection with is the primary risk factor for gastric cancer, the underlying mechanisms of pathogen persistence and consequential chronic inflammation are still not well understood. Conventional dendritic cells (cDCs), which are among the first immune cells to encounter in the gastric lining, and the cytokines and chemokines they secrete, contribute to both acute and chronic inflammation Therefore, this study aimed to unravel the contributions of specific signaling pathways within human CD1c cDCs (cDC2s) to the composition of secreted cytokines and chemokines in infection. Read More

Cancers (Basel) 2020 May 29;12(6). Epub 2020 May 29.

Radiology Unit, Department of Experimental, Diagnostic and Speciality Medicine, Sant'Orsola Hospital, University of Bologna, 40138 Bologna, Italy.

Gastric cancer (GC) is a common cancer worldwide. Its incidence and mortality vary depending on geographic area, with the highest rates in Asian countries, particularly in China, Japan, and South Korea. Accurate imaging staging has become crucial for the application of various treatment strategies, especially for curative treatments in early stages. Read More

Crit Rev Oncol Hematol 2020 May 21;152:102987. Epub 2020 May 21.

School of Human Health Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

TAS-102 is a preconstituted drug combination comprising an oral fluoropyrimidine (trifluridine, TFT) and a potent inhibitor of thymidine phosphorylase (tipiracil hydrochloride, TPI). TFT/TPI has recently received Food and Drug Administration (FDA) approval also for the treatment of gastric cancer after at least two lines of chemotherapy. The approval was based on a large phase 3 trial (TAGS), in which TAS-102 showed a 31 % decrease in the risk of death compared with placebo. Read More

Steroids 2020 May 30:108672. Epub 2020 May 30.

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address:

Allium chinense, as a side dish on Asian table, is often used in folk medicine for its health benefits. (25R)-5α-spirostan-3β-yl-3-O-acetyl-O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (A-24) is a bioactive steroidal saponin isolated from Allium chinense. Previously, we have shown that A-24 has cytotoxic effects on cancer cells, but not on normal cells. Read More

Neoplasma 2020 Jun 2. Epub 2020 Jun 2.

Chinese Medicine Department, Linyi People's Hospital, Linyi, China.

Gastric cancer (GC) is the second leading cause of cancer-associated deaths worldwide. Tanshinone IIA (TSN) is the pure extract from the root of red-rooted salvia and has been reported to inhibit the progression of GC cells. In this study, we investigated the microRNA (miRNA) mediated gene repression mechanism in TSN-administrated GC condition. Read More