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J Ethnopharmacol 2022 May 17:115381. Epub 2022 May 17.

Guangxi Key Laboratory for Bioactive Molecules Research and Evaluation & College of Pharmacy, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China; Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education & Center for Translational Medicine, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China. Electronic address:

Ethnopharmacological Relevance: Marsdenia tenacissima injection (MTE), a traditional Chinese medical injection extracted from the rattan of Marsdenia tenacissima (Roxb.) Moon, has been approved for clinical use in China as an adjuvant therapeutic agent in multiple cancers, including esophageal cancer, gastric cancer, lung cancer, and liver cancer. However, the activity and mechanism of MTE on prostate cancer (PCa) remain to be defined. Read More

Anal Biochem 2022 May 17:114737. Epub 2022 May 17.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China; West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, 610041, Sichuan, PR China. Electronic address:

As Helicobacter pylori (H. pylori) is closely related to the occurrence of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer, early detection of H. pylori is an urgent need. Read More

Appl Radiat Isot 2022 May 11;186:110273. Epub 2022 May 11.

Medical Physics Department, School of Medicine, Iran University of Medical Science, Tehran, Iran.

The goal of using radiopharmaceuticals for therapeutic purposes is twofold: first, the most damage to cancer cells and, second, the most negligible dose transfers to healthy tissues. As Lu has the potential to cure a wide range of malignancies due to its varied range of beta energies, Lu-BBN-GABA-DOTA has been developed for therapeutic applications. In addition, Lu-BBN-GABA-DOTA can be over-expressed on gastrin-releasing peptide (GRP) receptors of the prostate, breast, small cell lung cancer, gastric, and colon tumors. Read More

Eur J Med Chem 2022 May 11;238:114420. Epub 2022 May 11.

Institute of Pharmaceutical Research, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

Based on the previous synthesis of tetracyclic and tricyclic benzimidazoles starting from 1,4:3,6-dianhydro-d-fructose and o-phenylenediamines, a series of 5(6)-amino substituted tetracyclic and tricyclic benzimidazolequinones were obtained through the oxidation of 4,7-dimethoxy-benzimidazole analogues with bis(trifluoroacetoxy)iodobenzene (PIFA) and subsequent substitution with various aliphatic and aromatic amines. Biological evaluations of the target benzimidazolequinones indicated that all the arylamino-substituted benzimidazolequinones possess potent antitumour activity against human gastric cancer cells (MGC-803), especially compound a21-2. Furthermore, compound a21-2 inhibits gastric cancer cells proliferation and cell colony formation. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 May 20;PP. Epub 2022 May 20.

During the development of complex diseases, there is a critical transition from one status to another at a tipping point, which can be an early indicator of disease deterioration. To effectively enhance the performance of early risk identification, a novel dynamic network construction algorithm for identifying early warning signals based on a data-driven approach (EWS-DDA) was proposed. In EWS-DDA, the shrunken centroid was introduced to measure dynamic expression changes in assumed pathway reactions during the progression of complex disease for network construction and to define early warning signals by means of a data-driven approach. Read More

J Cancer Res Clin Oncol 2022 May 20. Epub 2022 May 20.

Laboratory of Molecular Biology, Research Center for Human Gene Therapy, Shanghai Second Medical University, Shanghai, 200025, People's Republic of China.

Acta Biochim Biophys Sin (Shanghai) 2022 Apr 25. Epub 2022 Apr 25.

Gastric cancer is one of the malignant tumors in the world. PAK4 plays an important role in the occurrence and development of gastric cancer, especially in the process of invasion and metastasis. Here we discover that CORO1C, a member of coronin family that regulates microfilament and lamellipodia formation, recruits cytoplasmic PAK4 to the leading edge of gastric cancer cells by C-terminal extension (CE) domain of CORO1C The localization of PAK4 on the leading edge of the cell depends on two necessary conditions: the phosphorylation of PAK4 on serine 99 and the binding to the CE domain of CORO1C. Read More

Acta Biochim Biophys Sin (Shanghai) 2022 Feb 25. Epub 2022 Feb 25.

Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Anticancer Agents Med Chem 2022 Apr 21. Epub 2022 Apr 21.

The Third Clinical Medicine College, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Background: Gastric cancer is a common global cancer disease. So far, the best choice for diagnosis and treatment of gastric cancer includes surgical resection, chemotherapy, and other targeted drug therapies, however, the overall survival rate of gastric cancer patients is still very low. Hypoxic microenvironment facilitates tumor cells to develop tolerance to chemotherapy and radiotherapy, and promotes the early invasion and metastasis of various tumors. Read More

J Anal Methods Chem 2022 10;2022:9740784. Epub 2022 May 10.

Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Carcinoembryonic antigen (CEA) is a glycoprotein, one of the common tumor biomarkers, found at low levels in body fluids. Generally, overexpression of CEA is found in various cancers, including ovarian, breast, lung, colorectal, gastric, and pancreatic cancers. Since CEA is an important tumor biomarker, the quantification of CEA is helpful for diagnosing cancer, monitoring tumor progression, and the follow-up treatment. Read More

Front Pediatr 2022 3;10:860960. Epub 2022 May 3.

Department of Pediatrics and Institute of Clinical Medicine, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, Tainan, Taiwan.

Background: infection is a major cause of peptic ulcers and gastric cancer. This study aimed to compare the eradication rate and essential costs of culture-based and empiric therapy strategies in treating pediatric infection.

Methods: We retrospectively enrolled patients aged <18 years with a diagnosis of infection who received esophagogastroduodenoscopy at two medical centers in southern Taiwan from 1998 to 2018. Read More

Front Oncol 2022 3;12:850389. Epub 2022 May 3.

School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.

Non-cardia gastric cancer was significantly associated with () infection. Reducing prevalence was an important prevention strategy for non-cardia gastric cancer. However, national-level data on the prevalence in non-cardia gastric cancer were limited in China. Read More

Front Oncol 2022 3;12:853768. Epub 2022 May 3.

Department of Chemistry and of Physics and Astronomy, State University of New York at Stony Brook, Stony Brook, NY, United States.

Gastric cancer is a daunting disease with a tragic impact on global health. It is the fourth most common cancer and has become the second most frequent cause of cancer death in recent times. According to the Lauren classification, gastric cancer can be classified into two types: intestinal and diffuse. Read More

Front Cell Infect Microbiol 2022 3;12:894836. Epub 2022 May 3.

Department of Medical Oncology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Hepatitis B virus (HBV) infection has been reported to be associated with gastric cancer (GC). Nonetheless, no study has revealed the role of HBV infection in the survival of patients with GC, and the mutation profiles of HBV-infected patients with GC have never been documented. Here, we performed an updated meta-analysis and found a significantly increased risk of GC in HBV-infected individuals (sOR, 1. Read More

Front Surg 2022 3;9:897583. Epub 2022 May 3.

National Demonstration Center for Experimental General Medicine Education, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, China.

Objective: To investigate the expression level of miR-4739 in gastric cancer (GC), analyze its diagnostic value in GC and the relationship with clinical pathological characteristics, and analyze its impact on the prognosis of patients.

Methods: A total of 96 patients with GC who underwent radical gastrectomy in our hospital from March 2017 to June 2021 were selected. GC tissues from all patients were collected, and normal tissues adjacent to cancer were collected as controls. Read More

Cancer Manag Res 2022 13;14:1729-1740. Epub 2022 May 13.

Digestive System Department, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Changsha, People's Republic of China.

Background: Long non-coding RNA LINC01232 plays an important role in the progression of metastasis in several cancers. However, the function of LINC01232 in gastric cancer is limited. Authors aimed to investigate the role and mechanism of LINC01232 in the metastasis of gastric cancer. Read More

Onco Targets Ther 2022 13;15:529-530. Epub 2022 May 13.

[This corrects the article DOI: 10.2147/OTT.S110918. Read More

Arch Med Sci 2022 13;18(3):753-760. Epub 2021 Apr 13.

Department of Oncology, Second People's Hospital of Dezhou, Decheng District, Dezhou, Shandong Province, China.

Introduction: Gastric cancer is a frequently detected malignancy, and its incidence has increased over the past decades in East Asia. The present study investigated the effect of 5,7,2, 5-tetrahydroxy-8,6-dimethoxyflavone (THDMF) on gastric cancer cells and explored the underlying mechanism. The study analysed cell viability changes, apoptotic features, and metastasis potential of treatment with THDMF. Read More

Cell Commun Signal 2022 May 19;20(1):68. Epub 2022 May 19.

Department of Clinical Laboratory, Jiangsu Cancer Hospital & The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research, Baiziting No. 42, Nanjing, 210009, Jiangsu, China.

Background: As a new kind of non-coding RNAs (ncRNAs), tRNA derivatives play an important role in gastric carcinoma (GC). Nevertheless, the underlying mechanism tRNA derivatives were involved in was rarely illustrated.

Methods: We screened out the tRNA derivative, tRF-Val-CAC-016, based on the tsRNA sequencing and demonstrated the effect tRF-Val-CAC-016 exerted on GC proliferation in vitro and in vivo. Read More

BMC Health Serv Res 2022 May 19;22(1):675. Epub 2022 May 19.

Department of Non-Communicable Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.

Background: Screening for upper gastrointestinal cancer (UGC) effectively reduces morbidity and mortality in gastric and esophageal cancers. It is considered one of the effective measures for cancer control in China, but studies on its functional quality are lacking. Our study assessed the quality of screening service funded by Upper Gastrointestinal Cancer Early diagnosis and treatment (UGCEDAT) and its correlation in Yangzhong People's hospital, China. Read More

World J Surg Oncol 2022 May 20;20(1):161. Epub 2022 May 20.

Department of Oncology, Maternal and Child Health Care Hospital of Zibo, Zibo, 255029, Shandong, China.

Background: The effective components contained in compound Kushen injection (CKI) and the genes and signalling pathways related to gastric cancer (GC) were analyzed through the network pharmacology method of traditional Chinese medicine, and various possible mechanisms by which CKI affects the proliferation, differentiation, survival, and metastasis of GC cells were discussed. The PI3K/AKT signalling pathway is considered to be one of the most important pathways targeted by CKI in the regulation of GC cells. The implementation of related cell experiments also confirmed the information we revealed. Read More

BMC Surg 2022 May 19;22(1):198. Epub 2022 May 19.

Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Chin Road, 20401, Keelung, Taiwan.

Background: Reduced-port laparoscopic gastrectomy can potentially reduce postoperative pain and improve recovery time. However, the inherent difficulty caused by the narrow manipulation angle makes this operation difficult, especially during lymph node dissection. The intrinsic advantage of the da Vinci robotic system might offset this difficulty, maintaining adequate surgical quality with risks of surgical complications equal to those by the conventional four-port robotic approach. Read More

Dig Dis Sci 2022 May 19. Epub 2022 May 19.

Department of Oncology, Affiliated Hospital of Xiangnan University, No.25, Renmin West Road, Chenzhou, 423000, Hunan, People's Republic of China.

Background: Radioresistance is a major obstacle for clinical treatment of gastric cancer (GC). has_circ_0003506 (circ_0003506) was reported as an oncogenic factor in GC, but its effect on radioresistant GC is unclear.

Aims: This study aimed to explore the role of circ_0003506 in radioresistance and regulatory mechanism. Read More

Langenbecks Arch Surg 2022 May 20. Epub 2022 May 20.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin Er Road, Shanghai, 200025, China.

Background: Chylous ascites (CA) after laparoscopic D3 lymphadenectomy for right colon cancer is not rare. However, the risk factors for CA have not been fully explored. Few studies have investigated the effect of CA on long-term prognosis. Read More

Sci Rep 2022 May 19;12(1):8400. Epub 2022 May 19.

Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.

Gastric adenocarcinoma is major type of gastric cancer that endangers human health. AKIRIN2 has been shown to be associated with cholangiocarcinoma promoting invasion and angiogenesis. In this study, AKIRIN2 is highly expressed in Gastric adenocarcinoma through bioinformatics analysis based on Stomach adenocarcinoma samples data from The Cancer Genome Atlas. Read More

Nat Commun 2022 May 19;13(1):2790. Epub 2022 May 19.

Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.

Epstein-Barr virus-associated gastric cancer (EBVaGC) shows a robust response to immune checkpoint inhibitors. Therefore, a cost-efficient and accessible tool is needed for discriminating EBV status in patients with gastric cancer. Here we introduce a deep convolutional neural network called EBVNet and its fusion with pathologists for predicting EBVaGC from histopathology. Read More

Sci Rep 2022 May 19;12(1):8349. Epub 2022 May 19.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo Hospital, 7-3-1, Hongo, Tokyo, 113-8655, Japan.

This study assessed the effect of magnifying endoscopy with narrow-band imaging (M-NBI) on the endoscopic differential diagnosis between intramucosal gastric carcinomas and adenomas with matched characteristics. Associations between magnified endoscopic findings and pathological high-grade cellular and architectural atypia were also investigated. In total, the records of 50 adenomas and 50 intramucosal well-differentiated adenocarcinomas matched by tumor size (≥ 20 mm or < 20 mm), shape (depression or non-depression), and color (red or non-red) were extracted. Read More

Oncologist 2022 May 19. Epub 2022 May 19.

Section of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA.

Background: Microangiopathic hemolytic anemia (MAHA) is a rare paraneoplastic syndrome that has been reported in patients with gastric signet ring cell carcinoma (SRCC). Clinical and prognostic features of MAHA in this setting have been poorly described.

Materials And Methods: We conducted a systematic review in 8 databases of gastric SRCC complicated by MAHA and performed a case-control study assessing factors associated with survival in patients with gastric SRCC and MAHA in our pooled cohort compared with age-, sex-, and stage-matched cases of gastric SRCC from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

Int J Surg 2022 May 16;102:106678. Epub 2022 May 16.

Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, No.150 Haping Road, Harbin, Heilongjiang, 150081, China. Electronic address:

Background: Laparoscopic gastrectomy (LG) has been widely used for advanced gastric cancer (GC), and its resection extent is not limited to distal gastrectomy. However, the superiority of this minimally invasive approach remains controversial. This study aimed to evaluate the benefits and risks of LG on the short- and long-term outcomes compared with open gastrectomy (OG) for GC. Read More

Gastroenterology 2022 May 16. Epub 2022 May 16.

Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida, USA. Electronic address:

Background & Aims: Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The role of Fibroblast Growth Factor Receptors in H. Read More