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    1 OF 55

    Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat.
    Cureus 2017 Jul 13;9(7):e1469. Epub 2017 Jul 13.
    Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
    Gas gangrene is one of the most serious infections of traumatic and surgical wounds. The importance lies in the fact that, if not managed at the right time, the condition is fatal. Though perianal cellulitis and gangrene are commonly reported in immunocompromised patients, we report the case of a patient with gas gangrene involving only the anal canal extending to the rectum, a rare presentation to be reported in literature. Read More

    Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A.
    PLoS One 2017 21;12(9):e0185215. Epub 2017 Sep 21.
    Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing, China.
    NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 against gas gangrene-associated Clostridium perfringens were studied for the first time. The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. Read More

    S Afr J Surg 2017 Sep;55(3):79
    Madadeni Hospital, University of Kwa-Zulu Natal.
    Background: Guillotine amputation for diabetic foot sepsis followed by an elective refashioning of the stump is regarded as standard practice. Primary amputation is associated with higher reamputation rates.

    Method: A prospective cohort study of 85 patients who underwent surgery for diabetic foot sepsis from 2014 to 2016 at Madadeni Provincial Hospital, KwaZulu-Natal was done. Read More

    Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis.
    Eur Arch Otorhinolaryngol 2017 Aug 20. Epub 2017 Aug 20.
    Department of Otolaryngology Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8575, Japan.
    Although clinical outcomes of descending necrotizing mediastinitis (DNM) and/or deep neck infection (DNI) have been extensively reported, no study has addressed delay in recovering oral ingestion after surgical interventions other than sporadic case reports. We herein compared clinical features of DNM and DNI cases over the same period, and clarified precipitating factors of delay in recovering oral ingestion by logistic regression analysis. We reviewed records of patients with DNI and DNM at our institution from August 2005 to July 2015. Read More

    The obesity paradox in patients with severe soft tissue infections.
    Am J Surg 2017 Sep 9;214(3):385-389. Epub 2016 Jul 9.
    Center for Surgery and Public Health, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School and Harvard T. H. Chan School of Public Heath, Boston, MA, USA; Trauma, Burn and Surgical Critical Care Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
    Background: The "obesity paradox" has been demonstrated in chronic diseases but not in acute surgery. We sought to determine whether obesity is associated with improved outcomes in patients with severe soft tissue infections (SSTIs).

    Methods: The 2006 to 2010 Nationwide Inpatient Sample was used to identify adult patients with SSTIs. Read More

    Scrotal Abscess Drained by Iatrogenic Urethral Fistula in an Adult Diabetic Male.
    Case Rep Urol 2017 17;2017:9820245. Epub 2017 Jul 17.
    Urology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
    A 46-year-old Caucasian male has been transferred to our urology department with a history of septic fever, uncompensated diabetes, pain, and scrotal swelling. On clinical examination, the left inguinal and scrotal area was swollen, tender, and painful; scrotal MR had been performed, showing the catheter tip in scrotal cavity and presence of gas. The case was diagnosed as scrotal abscess with urethroscrotal fistula. Read More

    Fatal liver gas gangrene after biliary surgery.
    Int J Surg Case Rep 2017 Jul 28;39:5-8. Epub 2017 Jul 28.
    Department of Surgery, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura City, Kanagawa, 247-8533, Japan.
    Introduction: Liver gas gangrene is a rare condition with a highly mortality rate. It is mostly associated with host factors, such as malignancy and immunosuppression.

    Presentation Of Case: A 57-year-old female was admitted to our hospital with abnormalities of her serum hepato-biliary enzymes. Read More

    Spontaneous C. septicum gas gangrene: A literature review.
    Anaerobe 2017 Aug 2;48:165-171. Epub 2017 Aug 2.
    Boise VA Medical Center, Boise, ID 83702, USA. Electronic address:
    As the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. Spontaneous or non-traumatic Clostridium septicum infection is one such unusual infection which has gained prominence. This article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. Read More

    Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland.
    Pol J Microbiol 2017 Jan;65(4):399-406
    Department of Infection Epidemiology, Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
    The objective of the study was to perform a comparative analysis of phenotypic and genetic similarity, determination of resistance profiles, detection of toxin-encoding genes and molecular typing of Clostridium perfringens isolates originating from patients with gas gangrene. The study encompassed three patients with a clinical and microbiological diagnosis of gas gangrene who were hospitalized in one of the hospitals of the Kujawsko-Pomorskie province in the same period of time between 8(th) April 2015 and 20(th) April 2015. The three C. Read More

    Assessment of Cultivable Oral Bacterial Flora from Important Venomous Snakes of India and Their Antibiotic Susceptibilities.
    Curr Microbiol 2017 Jul 21. Epub 2017 Jul 21.
    Haffkine Biopharmaceutical Corporation Limited, Pune, India.
    Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities. Read More

    Identifying and acting on potentially inappropriate care? Inadequacy of current hospital coding for this task.
    Diving Hyperb Med 2017 Jun;47(2):88-96
    Department of Diving and Hyperbaric Medicine, Royal Hobart Hospital, Hobart, Tasmania, Australia.
    Introduction: Recent Australian attempts to facilitate disinvestment in healthcare, by identifying instances of 'inappropriate' care from large Government datasets, are subject to significant methodological flaws. Amongst other criticisms has been the fact that the Government datasets utilized for this purpose correlate poorly with datasets collected by relevant professional bodies. Government data derive from official hospital coding, collected retrospectively by clerical personnel, whilst professional body data derive from unit-specific databases, collected contemporaneously with care by clinical personnel. Read More

    A rapid qualitative assay for detection of Clostridium perfringens in canned food products.
    Acta Biochim Pol 2017 9;64(2):207-213. Epub 2017 Jun 9.
    Department of Biotechnology, P D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa-388421, India.
    Clostridium perfringens (MTCC 1349) is a Gram-positive, anaerobic, endospore forming, and rod-shaped bacterium. This bacterium produces a variety of toxins under strict anaerobic environment. C. Read More

    Complete genome sequence of Clostridium perfringens CBA7123 isolated from a faecal sample from Korea.
    Gut Pathog 2017 2;9:32. Epub 2017 Jun 2.
    Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755 Republic of Korea.
    Background: Clostridium perfringens is an opportunistic human pathogen that causes necrotic enteritis, mild diarrhea, clostridial myonecrosis or gas gangrene, sepsis, etc. In this study, we aim to determine the pathogenesis of this bacterium at the genomic level. The genome of strain CBA7123 was sequenced, and a comparative genomic analysis between strain CBA7123 and four other related C. Read More

    Benign Subcutaneous Emphysema of the Upper Limb: A Case Report.
    Malays Orthop J 2016 Nov;10(3):39-41
    Department of Orthopaedic Surgery, Raja Isteri Pengiran Anak Saleha (RIPAS) Hospital, Bandar Seri Begawan, Brunei Darussalam.
    Subcutaneous emphysema is the presence of gas or air in the subcutaneous tissue plane. The term is generally used to describe any soft tissue emphysema of the body wall or limbs, it can result from benign causes, most commonly secondary to trauma or from a life-threatening infection by gas gangrene or necrotising fasciitis. A case of subcutaneous emphysema involving the upper limb resulting from a trivial laceration to the elbow is reported and the importance of distinguishing between the two causes of subcutaneous emphysema is highlighted. Read More

    Clinical Serum Therapy: Benefits, Cautions, and Potential Applications.
    Keio J Med 2017 Apr 28. Epub 2017 Apr 28.
    Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan.
    Blood serum from immunized humans or animals (e.g., horses) contains relevant antibodies and has been used as serum therapy to treat many diseases or envenomation events. Read More

    A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens α-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.
    Probiotics Antimicrob Proteins 2017 Apr 11. Epub 2017 Apr 11.
    Department of Anaerobic Bacterial Vaccine Research and Production, Kerman Branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran.
    The alpha-toxin is one of the virulence factors of Clostridium perfringens for gas gangrene in humans and animals or necrotic enteritis in poultry. The C-terminal domain of this toxin ( cpa 247-370 ) was synthesized and cloned into pT1NX vector to construct the pT1NX-alpha plasmid. This surface-expressing plasmid was electroporated into Lactobacillus casei ATCC 393, generating the recombinant L. Read More

    Identification, Isolation, and Phylogenetic Analysis of Clostridium perfringens Type A and Type C from Wild Boar ( Sus scrofa ) in the People's Republic of China.
    J Wildl Dis 2017 Jul 22;53(3):642-648. Epub 2017 Mar 22.
    1 National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, People's Republic of China 100101.
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). Read More

    A fatal Clostridium perfringens infection with hemolysis after chemotherapy in an adolescent.
    Arch Argent Pediatr 2017 04;115(2):e92-e95
    Department of Pediatrics, Pediatric Intensive Care Unit, Faculty of Medicine, Hacettepe University.
    Gas gangrene, clostridial myonecrosis, is one of the most serious infectious diseases, characterized by rapidly progressive destruction of deep soft tissues and production of gas within the tissues. We presented a case of fatal spontaneous gas gangrene due to Clostridium perfringens in a patient with acute lymphoblastic leukemia during remission induction chemotherapy phase. Read More

    [Necrotizing fasciitis of the upper and lower extremities].
    Chirurg 2017 Apr;88(4):353-366
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgie-Zentrum, operatives Referenzzentrum für Gliedmaßentumoren, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.
    Necrotizing fasciitis is a potentially fatal soft tissue infection that may affect the upper and lower extremities, scrotum, perineum and abdominal wall. Typically, the infection demonstrates rapid spreading along the fascial planes leading to sepsis with mortality rates of 15-46%. Without adequate treatment, the mortality rate increases to close to 100%. Read More

    Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.
    Toxicon 2017 May 1;130:79-86. Epub 2017 Mar 1.
    Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 130122, Jilin Province, China. Electronic address:
    Alpha-toxin produced by Clostridium perfringens is an important virulence factor, causing food poisoning and gas gangrene in humans. As such, it is considered a potential bioterrorism threat. To date, there is still no human effective therapeutic drug against alpha-toxin. Read More

    Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model.
    Folia Microbiol (Praha) 2017 Jul 17;62(4):343-353. Epub 2017 Feb 17.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior, 474002, India.
    Clostridium perfringens is a Validated Biological Agent and a pathogen of medical, veterinary, and military significance. Gas gangrene is the most destructive of all the clostridial diseases and is caused by C. perfringens type A strains wherein the infection spreads quickly (several inches per hour) with production of gas. Read More

    Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.
    Chem Phys Lipids 2017 Mar 16;203:54-70. Epub 2017 Jan 16.
    Unidad de Biofísica (CSIC, UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080 Bilbao, Spain. Electronic address:
    Clostridium perfringens alpha-toxin (ATX) is considered as a prototype of cytotoxic bacterial phospholipases C, and is the major virulence factor in C. perfringens-induced gas gangrene. It is known that, depending on the dose, ATX causes membrane disruption and cytolysis or only limited hydrolysis of its substrates. Read More

    Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
    Toxins (Basel) 2016 Dec 22;9(1). Epub 2016 Dec 22.
    Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
    Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. Read More

    Clostridium perfringens: a rare cause of spondylodiscitis case report and review of the literature.
    Br J Neurosurg 2016 Dec 14:1-3. Epub 2016 Dec 14.
    a Department of Orthopaedic , Study Conducted at the University Hamburg Eppendorf , Hamburg , Germany.
    Presented is a case of a 64-year old male with a unique and yet unreported case of a spondylodiscitis caused by Clostridium perfringens. Becoming symptomatic with massive neurological deficits. Computed tomography (CT) revealed typical signs of spondylodiscitis involving the vertebral body L5 with extensive vacuum phenomenon. Read More

    Fulminant Clostridium perfringens Sepsis in Kidney Transplant: A Case Report.
    Transplant Proc 2016 Nov;48(9):3112-3114
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
    Background: Infections, particularly urinary tract infections, and cardiovascular accidents are the main causes of morbidity and mortality during the 1st year after kidney transplantation (KT). Bacteria and viruses, such as Escherichia coli, Enteroccoci, and Polyoma BK virus are common in the 1st 6 months, so they are controlled routinely. On the other hand, Clostridium perfringens infection is a rare life-threatening condition, associated with a high mortality rate especially in the transplant population, that is not controlled routinely. Read More

    Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines.
    Toxins (Basel) 2016 Nov 21;8(11). Epub 2016 Nov 21.
    Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas, Pelotas CEP 96160-000, Rio Grande do Sul, Brazil.
    Clostridium perfringens is a spore-forming, commensal, ubiquitous bacterium that is present in the gastrointestinal tract of healthy humans and animals. This bacterium produces up to 18 toxins. The species is classified into five toxinotypes (A-E) according to the toxins that the bacterium produces: alpha, beta, epsilon, or iota. Read More

    Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets.
    Toxins (Basel) 2016 Nov 19;8(11). Epub 2016 Nov 19.
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Room 420, Bridgeside Point II Building, 450 Technology Drive, Pittsburgh, PA 15219, USA.
    Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. Read More

    Soft Tissue Reconstruction Pyramid for the Diabetic Charcot Foot.
    Clin Podiatr Med Surg 2017 Jan 3;34(1):69-76. Epub 2016 Sep 3.
    Division of Podiatric Medicine and Surgery, Department of Orthopaedics, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, MSC 7776, San Antonio, TX 78229, USA.
    Foot and ankle ulcerations in patients with diabetic Charcot neuroarthropathy (DCN) occur frequently and can be challenging to address surgically when conservative care fails. Patients with acute or chronic diabetic foot ulcers (DFU) are at continued risk for development of osteomyelitis, septic arthritis, gas gangrene, and potential lower extremity amputation. Concurrent vasculopathy and peripheral neuropathy as well as uncontrolled medical comorbidities complicate the treatment approach. Read More

    Georgian Med News 2016 Sep(258):73-76
    Tbilisi State Medical University; The First University Clinic, Georgia.
    Anaerobic clostridial infection is the most severe form of paraproctitis. The incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. Clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. Read More

    Factitious Disorder Presenting with Attempted Simulation of Fournier's Gangrene.
    J Radiol Case Rep 2016 Sep 30;10(9):26-34. Epub 2016 Sep 30.
    Department of Radiology, Stanford University, Palo Alto, USA.
    Fournier's gangrene is a severe polymicrobial necrotizing fasciitis of the perineal, genital, or perianal regions. The classic presentation is severe pain and swelling with systemic signs. Crepitus and cutaneous necrosis are often seen. Read More

    Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils.
    Biol Pharm Bull 2016 ;39(10):1694-1700
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
    Clostridium perfringens type A, a Gram-positive, anaerobic bacterium, causes gas gangrene. Recently, we reported that C. perfringens α-toxin blocked neutrophil differentiation in an enzyme activity-dependent manner to impair host innate immunity, which should be crucial for the pathogenesis of C. Read More

    Safety of transport and hyperbaric oxygen treatment in critically-ill patients from Padua hospitals into a centrally-located, stand-alone hyperbaric facility.
    Diving Hyperb Med 2016 Sep;46(3):155-159
    Department of Surgery and Anesthesiology, University of South Florida, Tampa, Florida ; TeamHealth Anesthesia, Tampa General Hospital, 1 Tampa General Hospital Circle, Suite A327, Tampa, Florida 33606, USA.
    Introduction: Some patients admitted to the intensive care unit (ICU) might require repetitive hyperbaric oxygen treatment (HBOT) while receiving critical care. In such cases, the presence of a hyperbaric chamber located inside or near an ICU is preferable; however, this set-up is not always possible. In Padua, the "Associazione Tecnici IPerbarici" hyperbaric centre is a stand-alone facility outside of a hospital. Read More

    Clostridium septicum: An Unusual Link to a Lower Gastrointestinal Bleed.
    Case Rep Gastroenterol 2016 May-Aug;10(2):489-493. Epub 2016 Sep 12.
    Gastroenterology Division, Department of Medicine, SUNY Upstate Medical University, Syracuse, N.Y., USA.
    Clostridium septicum is a highly virulent pathogen which is associated with colorectal malignancy, hematological malignancy, immunosuppression, diabetes mellitus and cyclical neutropenia. Presentation may include disseminated clostridial infection in the form of septicemia, gas gangrene, and mycotic aortic aneurysms. We report the case of a 62-year-old female presenting with necrotizing fasciitis of her left thigh and subsequently developing rectal bleeding. Read More

    Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review.
    Intensive Care Med 2016 Dec 3;42(12):1899-1911. Epub 2016 Oct 3.
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 4523 Clayton Ave, Campus Box 8052, St. Louis, MO, 63110, USA.
    Purpose: To review the salient features of the diagnosis and management of the most common skin and soft tissue infections (SSTI). This review focuses on severe SSTIs that require care in an intensive care unit (ICU), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis.

    Methods: Guidelines, expert opinion, and local institutional policies were reviewed. Read More

    Fatal Clostridium perfringens Septicemia After Colonoscopic Polypectomy, Without Bowel Perforation.
    J Forensic Sci 2016 Nov 22;61(6):1689-1692. Epub 2016 Sep 22.
    Section of Legal Medicine, University of Perugia, via T. di Joannuccio snc, Terni, 05100, Italy.
    Since its introduction, colonoscopy has played an important role as a diagnostic, therapeutic, and screening tool. In general, colonoscopy is regarded as a safe procedure, but complications may occur. The most dreaded of these complications is colonic perforation. Read More

    The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.
    PLoS One 2016 16;11(9):e0162981. Epub 2016 Sep 16.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
    The ability of a pathogenic bacterium to scavenge iron from its host is important for its growth and survival during an infection. Our studies on C. perfringens gas gangrene strain JIR325, a derivative of strain 13, showed that it is capable of utilizing both human hemoglobin and ferric chloride, but not human holo-transferrin, as an iron source for in vitro growth. Read More

    Radiological diagnosis of gas gangrene in a fetus at term.
    Taiwan J Obstet Gynecol 2016 Aug;55(4):582-4
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
    Objective: To report a case of gas gangrene in a fetus at term, which was diagnosed by antenatal computed tomography (CT) imaging.

    Case Report: A 23-year-old primiparous woman, who did not undergo any prenatal health checks until term, developed hypertension, proteinuria, and clouding of consciousness, and experienced intrauterine fetal death. A single, mature fetus with voluminous gas bubbles was observed on CT, which was consistent with a diagnosis of fetal gas gangrene. Read More

    Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review.
    Surg Laparosc Endosc Percutan Tech 2016 Aug;26(4):278-81
    Department of Surgery, MC Slotervaart, Amsterdam, The Netherlands.
    Clostridial gas gangrene is a rare, yet severe, complication after laparoscopic cholecystectomy. We present a case report of a 48-year-old man with obesity, coronary artery disease, and diabetes, who developed clostridial gas gangrene of the abdominal wall after an uncomplicated laparoscopic cholecystectomy. Although the diagnosis was missed initially, successful radical surgical debridement was performed and the patient survived. Read More

    A case of acute onset postoperative gas gangrene caused by Clostridium perfringens.
    BMC Res Notes 2016 Aug 3;9:385. Epub 2016 Aug 3.
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
    Background: Gas gangrene is a necrotic infection of soft tissue associated with high mortality rates. We report a case of postoperative gas gangrene with very acute onset and rapid progression of symptoms. To our knowledge, this case is the most acute onset of postoperative gas gangrene ever reported. Read More

    Regulation of Toxin Production in Clostridium perfringens.
    Toxins (Basel) 2016 Jul 5;8(7). Epub 2016 Jul 5.
    Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.
    The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. Read More

    Critical Manifestations of Pneumoscrotum.
    Curr Urol 2016 May 20;9(2):62-6. Epub 2016 May 20.
    Department of Physiology and BiophysicsSUNY at Stony Brook, New York, N.Y., USA; Department of Urology, SUNY at Stony Brook, New York, N.Y., USA.
    Introduction: Pneumoscrotum is a critical, physical finding that may indicate significant morbidity and mortality. Accumulation of gas in the scrotum can be primary or secondary.

    Objective: This paper discusses rapid diagnosis and treatment options. Read More

    Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report.
    J Tissue Viability 2016 Nov 24;25(4):225-228. Epub 2016 Jun 24.
    Discipline of Podiatric Medicine, College of Medicine Nursing & Health Sciences, Aras Moyola, National University of Ireland Galway, Ireland. Electronic address:
    This report documents an unusual case of distal symmetrical peripheral neuropathy (DSPN) in an otherwise healthy patient without diabetes mellitus (DM) presenting to a podiatric wound care clinic. The development of gas gangrene coupled with Charcot neuroarthropathic changes ultimately resulted in a potentially life-saving transmetatarsal (TMT) amputation. Causation of, or at least a contributor to, the DSPN was likely phenytoin usage for epileptic seizures. Read More

    Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection.
    J Gynecol Surg 2016 Jun;32(3):182-184
    Richmond University Medical Center , Staten Island, NY.
    Background:Clostridium perfringens gas gangrene is an extremely rare and fatal infection. Necrosis of the myometrium is rarely seen and has only been recorded in 18 cases to date. Of these 18 reported cases, only 5 have occurred in nonpregnant women. Read More

    Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens.
    Int J Med Microbiol 2016 Sep 20;306(6):429-42. Epub 2016 May 20.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Electronic address:
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that causes human gas gangrene (clostridial myonecrosis) and food poisoning. Early studies showed that virulence was regulated by the VirSR two-component signal transduction system. However, our identification of the RevR orphan response regulator indicated that more than one system was involved in controlling virulence. Read More

    Massive gas gangrene secondary to occult colon carcinoma.
    Radiol Case Rep 2016 Jun 5;11(2):67-9. Epub 2016 Mar 5.
    Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710, USA.
    Gas gangrene is a rare but often fatal soft-tissue infection. Because it is uncommon and the classic symptom of crepitus does not appear until the infection is advanced, prompt diagnosis requires a high index of suspicion. We present a case report of a middle-aged man who presented with acute onset lower-extremity pain that was initially thought to be due to deep vein thrombosis. Read More

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