1,047 results match your criteria Ganser Syndrome


Phase I/II study on cytarabine and idarubicin combined with escalating doses of clofarabine in newly diagnosed patients with acute myeloid leukaemia and high risk for induction failure (AMLSG 17-10 CIARA trial).

Br J Haematol 2018 Oct;183(2):235-241

Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

This open-label, multicentre phase I/II study determined the maximum tolerated dose (MTD), safety and efficacy of clofarabine administered with cytarabine and idarubicin in newly diagnosed acute myeloid leukaemia (AML) patients lacking favourable genetic aberrations. The MTD was 30 mg/m clofarabine for patients below and above 60 years. The most frequently reported grade 3-4 non-haematological adverse events were infectious and gastrointestinal toxicities. Read More

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October 2018
4 Reads

Haploidentical versus unrelated allogeneic stem cell transplantation for relapsed/refractory acute myeloid leukemia: A report of 1578 patients from the Acute Leukemia Working Party of EBMT.

Haematologica 2018 Oct 25. Epub 2018 Oct 25.

Hematology Division, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel.

Primary refractory or relapsed acute myeloid leukemia is associated with dismal prognosis. Allogeneic stem cell transplantation is the only therapeutic option that offers prolonged survival and cure in this setting. In the absence of a matched sibling donor, transplantation from unrelated 10/10 or 9/10 and haploidentical donors are potential alternatives. Read More

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October 2018
11 Reads

Routes of Clonal Evolution into Complex Karyotypes in Myelodysplastic Syndrome Patients with 5q Deletion.

Int J Mol Sci 2018 Oct 21;19(10). Epub 2018 Oct 21.

Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany.

Myelodysplastic syndrome (MDS) can easily transform into acute myeloid leukemia (AML), a process which is often associated with clonal evolution and development of complex karyotypes. Deletion of 5q (del(5q)) is the most frequent aberration in complex karyotypes. This prompted us to analyze clonal evolution in MDS patients with del(5q). Read More

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October 2018
5 Reads

miR-125b regulates chemotaxis and survival of bone marrow derived granulocytes in vitro and in vivo.

PLoS One 2018 4;13(10):e0204942. Epub 2018 Oct 4.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

The evolutionary conserved miR-125b is highly expressed in hematopoietic stem cells (HSC) enhancing self-renewal and survival. Accordingly, over-expression of miR-125b in HSC may induce myeloproliferative neoplasms and leukemia with long latency. During hematopoietic cell maturation miR-125b expression decreases, and the function of miR-125b in mature granulocytes is not yet known. Read More

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October 2018
2 Reads

Molecules on rails: friction anisotropy and preferential sliding directions of organic nanocrystallites on two-dimensional materials.

Nanoscale 2018 Oct 2;10(39):18835-18845. Epub 2018 Oct 2.

Graphene Laboratory of Center for Solid State Physics and New Materials, Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia.

Two-dimensional (2D) materials are envisaged as ultra-thin solid lubricants for nanomechanical systems. So far, their frictional properties at the nanoscale have been studied by standard friction force microscopy. However, lateral manipulation of nanoparticles is a more suitable method to study the dependence of friction on the crystallography of two contacting surfaces. Read More

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October 2018
1 Read

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML.

Blood 2018 Oct 6;132(16):1703-1713. Epub 2018 Sep 6.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation and.

Molecular measurable residual disease (MRD) assessment is not established in approximately 60% of acute myeloid leukemia (AML) patients because of the lack of suitable markers for quantitative real-time polymerase chain reaction. To overcome this limitation, we established an error-corrected next-generation sequencing (NGS) MRD approach that can be applied to any somatic gene mutation. The clinical significance of this approach was evaluated in 116 AML patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) in complete morphologic remission (CR). Read More

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October 2018
5 Reads

Conditioning intensity in secondary AML with prior myelodysplastic syndrome/myeloproliferative disorders: an EBMT ALWP study.

Blood Adv 2018 Aug;2(16):2127-2135

European Blood and Marrow Transplant Paris Study Office/CEREST-TC, Paris, France.

Patients with secondary AML (sAML) with antecedent myelodysplastic syndrome (MDS) or myeloproliferative neoplasms (MPNs) tend to have high-risk disease based on the older age of patients, high-risk cytogenetics, and higher number of prior treatments. Allogeneic hematopoietic cell transplant (HCT) is the only potentially curative therapy available. Eight hundred and two adults with sAML and prior MDS/MPN who received a first HCT between 2000 and 2016 were included in the European Society for Blood and Marrow Transplant (EBMT) Acute Leukemia Working Party (ALWP) study. Read More

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August 2018
8 Reads

Improved short- and long-term outcome of allogeneic stem cell recipients admitted to the intensive care unit: a retrospective longitudinal analysis of 942 patients.

Intensive Care Med 2018 Sep 23;44(9):1483-1492. Epub 2018 Aug 23.

Department for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Purpose: Intensive care unit (ICU) admission of allogeneic hematopoietic stem cell transplant (HSCT) recipients is associated with relatively poor outcome. Since longitudinal data on this topic remains scarce, we analyzed reasons for ICU admission as well as short- and long-term outcome of critically ill HSCT recipients.

Methods: A total of 942 consecutive adult patients were transplanted at Hannover Medical School from 2000 to 2013. Read More

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September 2018
5 Reads

Comparison of FLAMSA-based reduced intensity conditioning with treosulfan/fludarabine conditioning for patients with acute myeloid leukemia: an ALWP/EBMT analysis.

Bone Marrow Transplant 2018 Aug 7. Epub 2018 Aug 7.

EBMT Paris Office, CEREST-TC, Department of Hematology, Saint Antoine Hospital, Paris, France.

FLAMSA followed by sequential reduced intensity conditioning and treosulfan/fludarabine are frequently used conditioning approaches used in centers of the European Society for Blood and Marrow Transplantation (EBMT) for older patients with acute myeloid leukemia (AML). It is currently unknown whether any of these regimens is superior to the others in terms of disease control and toxicity. Using the Acute Leukemia Working Party/EBMT multicenter registry we compared the outcomes of AML patients 45-65 of age transplanted between the years 2007 and 2016. Read More

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August 2018
2 Reads

[Implementation of Medical Emergency Teams to Improve Perioperative Patient Safety. Who? When? How?]

Zentralbl Chir 2018 Jul 4. Epub 2018 Jul 4.

Klinik und Poliklinik für Anästhesiologie und Operative Intensivtherapie, Universitätsklinikum Carl Gustav Carus, Dresden, Deutschland.

In contrast to prehospital emergency medicine, there are no comparable established structures or statutory requirements for structural and procedural organisation, or qualification of personnel and equipment for in-hospital emergency care in Germany. However, in perioperative patients, unexpected complications are fairly common on regular wards. Often, even hours before a possible critical event, warning signs of deterioration are present, which too often go unnoticed. Read More

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Fast quantitative optical detection of heat dissipation by surface plasmon polaritons.

Nanoscale 2018 Jul;10(25):11894-11900

Department of Physics, University of Konstanz, 78457 Konstanz, Germany.

Heat management at the nanoscale is an issue of increasing importance. In optoelectronic devices the transport and decay of plasmons contribute to the dissipation of heat. By comparison of experimental data and simulations we demonstrate that it is possible to gain quantitative information about excitation, propagation and decay of surface plasmon polaritons (SPPs) in a thin gold stripe supported by a silicon membrane. Read More

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July 2018
1 Read

The majority of patients with newly diagnosed juvenile idiopathic arthritis achieve a health-related quality of life that is similar to that of healthy peers: results of the German multicenter inception cohort (ICON).

Arthritis Res Ther 2018 May 30;20(1):106. Epub 2018 May 30.

Deutsches Rheuma-Forschungszentrum Berlin, Epidemiology Unit, Charitéplatz 1, 10117, Berlin, Germany.

Background: Achieving the best possible health-related quality of life (HRQoL) for a patient is an important treatment goal in juvenile idiopathic arthritis (JIA). We investigated the 36-month trajectories of HRQoL in children with JIA compared with healthy peers and identified the predictors of an unfavorable HRQoL.

Methods: Patients with a recent JIA diagnosis were enrolled in the German inception cohort study ICON. Read More

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May 2018
8 Reads

High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.

Nat Struct Mol Biol 2018 May 4;25(5):425-434. Epub 2018 May 4.

Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.

Dynamic ensembles hold great promise in advancing RNA-targeted drug discovery. Here we subjected the transactivation response element (TAR) RNA from human immunodeficiency virus type-1 to experimental high-throughput screening against ~100,000 drug-like small molecules. Results were augmented with 170 known TAR-binding molecules and used to generate sublibraries optimized for evaluating enrichment when virtually screening a dynamic ensemble of TAR determined by combining NMR spectroscopy data and molecular dynamics simulations. Read More

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May 2018
12 Reads

Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia-results of the AMLSG 11-08 trial.

Leukemia 2018 Jul 17;32(7):1621-1630. Epub 2018 Apr 17.

Klinik für Innere Medizin III, Universitätsklinikum Ulm, Ulm, Germany.

In this phase Ib/IIa study (ClinicalTrials.gov Identifier: NCT00850382) of the German-Austrian AML Study Group (AMLSG) the multikinase inhibitor dasatinib was added to intensive induction and consolidation chemotherapy and administered as single agent for 1-year maintenance in first-line treatment of adult patients with core-binding factor (CBF) acute myeloid leukemia (AML). The primary combined end point in this study was safety and feasibility, and included the rates of early (ED) and hypoplastic (HD) deaths, pleural/pericardial effusion 3°/4° and liver toxicity 3°/4°, and the rate of refractory disease. Read More

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July 2018
14 Reads

Diagnostic value of highly-sensitive chimerism analysis after allogeneic stem cell transplantation.

Bone Marrow Transplant 2018 May 2. Epub 2018 May 2.

Dept. of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Conventional analysis of host chimerism (HC) frequently fails to detect relapse before its clinical manifestation in patients with hematological malignancies after allogeneic stem cell transplantation (allo-SCT). Quantitative PCR (qPCR)-based highly-sensitive chimerism analysis extends the detection limit of conventional (short tandem repeats-based) chimerism analysis from 1 to 0.01% host cells in whole blood. Read More

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From the black Atlantic to the bleak Pacific: Re-reading "Benito Cereno".

Authors:
Alexandra Ganser

Atl Stud (Abingdon) 2018 13;15(2):218-237. Epub 2018 Mar 13.

Department of English, University of Vienna, Vienna, Austria.

Herman Melville's novella "Benito Cereno" (1855/56) is one of the best-studied texts both within Melville's oeuvre and nineteenth-century American literature in general. In recent decades, its puzzling structure and fragmented narrative perspective as well as its symbolism and themes have been subject to critical scrutiny mostly in the context of inquiries into the text's racial politics regarding the institution of slavery. More specifically, the canonical tale about a slave uprising on the ship , its detection by a Massachusetts-born captain and its consequences, has been discussed in the context of Paul Gilroy's black Atlantic paradigm. Read More

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Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.

Biol Blood Marrow Transplant 2018 Jul 17;24(7):1406-1414. Epub 2018 Apr 17.

EBMT Paris study office/CEREST-TC, Paris, France; Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Secondary acute myeloid leukemia (sAML) has been associated with inferior outcomes compared with de novo AML. Little is known about patient risk factors and outcomes in sAML after allogeneic hematopoietic stem cell transplantation (HCT); thus, this large systemic analysis of the European Society for Blood and Bone Marrow Transplantation registry was performed. This study included 4997 patients with sAML who received HCT from 2000 to 2016. Read More

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July 2018
10 Reads

The German version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR).

Rheumatol Int 2018 Apr 7;38(Suppl 1):211-218. Epub 2018 Apr 7.

Clinica Pediatrica e Reumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO), Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy.

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the German language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Read More

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April 2018
7 Reads

IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis.

Arthritis Rheumatol 2018 Aug 28;70(8):1319-1330. Epub 2018 Jun 28.

National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.

Objective: To determine whether systemic juvenile idiopathic arthritis (JIA) susceptibility loci that were identified by candidate gene studies demonstrate association with systemic JIA in the largest study population assembled to date.

Methods: Single-nucleotide polymorphisms (SNPs) from 11 previously reported systemic JIA risk loci were examined for association in 9 populations, including 770 patients with systemic JIA and 6,947 controls. The effect of systemic JIA-associated SNPs on gene expression was evaluated in silico in paired whole genome and RNA sequencing data from the lymphoblastoid cell lines (LCLs) of 373 European subjects from the 1000 Genomes Project. Read More

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August 2018
18 Reads

The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry.

Rheumatology (Oxford) 2018 03 27. Epub 2018 Mar 27.

Section of Paediatric Rheumatology, Children's Hospital, Osteology, Immunology and Infectious Diseases, University of Wuerzburg, Germany.

Objectives: Chronic non-bacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder characterized by sterile bone osteolytic lesions. The aim of this study was to evaluate the demographic data and clinical, instrumental and therapeutic features at baseline in a large series of CNO/CRMO patients enrolled in the Eurofever registry.

Methods: A web-based registry collected retrospective data on patients affected by CRMO/CNO. Read More

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March 2018
8 Reads

Structural properties determining low K affinity of the selectivity filter in the TWIK1 K channel.

J Biol Chem 2018 May 15;293(18):6969-6984. Epub 2018 Mar 15.

From the Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, and

Canonical K channels are tetrameric and highly K-selective, whereas two-pore-domain K (K2P) channels form dimers, but with a similar pore architecture. A two-pore-domain potassium channel TWIK1 (KCNK1 or K2P1) allows permeation of Na and other monovalent ions, resulting mainly from the presence of Thr-118 in the P1 domain. However, the mechanistic basis for this reduced selectivity is unclear. Read More

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May 2018
1 Read

Switching "on" and "off" the adhesion in stimuli-responsive elastomers.

Soft Matter 2018 Mar;14(13):2547-2559

Polymer Competence Center Leoben GmbH, Roseggerstraße 12, A-8700 Leoben, Austria.

The present work aims at the preparation of dry adhesives with switchable bonding properties by using the reversible nature of the [4πs+4πs] cycloaddition of anthracenes. Photo-responsive hydrogenated carboxylated nitrile butadiene rubber with photo-responsive pendant anthracene groups is prepared by one-pot synthesis. The formation of 3D networks relies on the photodimerization of the anthracene moieties upon UV exposure (λ > 300 nm). Read More

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Identification of an Amino Acid Motif in HLA-DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis.

Arthritis Rheumatol 2018 Jul 29;70(7):1155-1165. Epub 2018 May 29.

University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Objective: Uveitis is a visually debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. This study was undertaken to identify genetic susceptibility loci for uveitis in JIA, using a genome-wide association study in 522 children with JIA. Read More

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July 2018
38 Reads

A practical approach for the optimization of channel integrity in the sealing of shallow microfluidic devices made from cyclic olefin polymer.

Biomed Microdevices 2018 02 24;20(2):24. Epub 2018 Feb 24.

Center for Manufacturing Innovation, Fraunhofer USA, Brookline, MA, 02446, USA.

A reduced channel height in microfluidic Lab-on-a-Chip (LOC) devices enables a reduction in the required volume of sample and reagents. LOC devices are most often manufactured by microstructuring a planar substrate and subsequently sealing it with a cover film. However, shallow chip designs, made from polymers, are sensitive to channel deformation during the sealing of the microfluidic device. Read More

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February 2018
2 Reads

Acquired long QT syndrome during conditioning for allogeneic stem cell transplantation-are we aware of this side effect?

Ann Hematol 2018 Jun 9;97(6):1111-1113. Epub 2018 Feb 9.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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June 2018
9 Reads

Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma.

Oncotarget 2018 Jan 18;9(2):2320-2328. Epub 2017 Dec 18.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Immunophenotypic analysis using multiparameter flow cytometry is an indispensable tool for diagnosis and management of acute leukemia. Mouse models have been widely used for medical research for more than 100 years and are indispensable for leukemia research. However, immunophenotypic analysis of murine leukemia was not always performed in published studies, and blast gating for isolation of blasts was shown only in very few studies. Read More

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January 2018
3 Reads

Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany.

Pediatr Rheumatol Online J 2018 Jan 22;16(1). Epub 2018 Jan 22.

Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Albert-Schweitzer-Campus 1, Building W30, 48149, Münster, Germany.

Background: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease associated with chronic arthritis. Early diagnosis and effective therapy of SJIA is desirable, so that complications are avoided. The PRO-KIND initiative of the German Society for Pediatric Rheumatology (GKJR) aims to define consensus-based strategies to harmonize diagnostic and therapeutic approaches in Germany. Read More

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January 2018
24 Reads

Clinical impact of expression in high-risk acute promyelocytic leukemia.

Blood Adv 2017 Sep 15;1(21):1807-1814. Epub 2017 Sep 15.

Department of Internal Medicine, Medical School of Ribeirao Preto and.

Although overexpression of the brain and acute leukemia, cytoplasmic () gene is associated with primary resistant disease and shorter relapse-free, disease-free, and overall survival in different subsets of acute myeloid leukemia (AML), little is known about its clinical impact in acute promyelocytic leukemia (APL). Using real-time reverse transcriptase polymerase chain reaction, we showed that expression is significantly lower in APL compared with other subsets of AML ( < .001). Read More

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September 2017
7 Reads

Combining adhesive contact mechanics with a viscoelastic material model to probe local material properties by AFM.

Soft Matter 2017 Dec;14(1):140-150

Institute of Physics, Montanuniversitaet Leoben, Franz Josef - Str. 18, 8700 Leoben, Austria.

Viscoelastic properties are often measured using probe based techniques such as nanoindentation (NI) and atomic force microscopy (AFM). Rarely, however, are these methods verified. In this article, we present a method that combines contact mechanics with a viscoelastic model (VEM) composed of springs and dashpots. Read More

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December 2017
6 Reads

Experience with etanercept, tocilizumab and interleukin-1 inhibitors in systemic onset juvenile idiopathic arthritis patients from the BIKER registry.

Arthritis Res Ther 2017 Nov 22;19(1):256. Epub 2017 Nov 22.

German Center for Pediatric and Adolescents´ Rheumatology, Garmisch-Partenkirchen, Germany.

Background: Treatment of systemic onset juvenile idiopathic arthritis JIA (sJIA), although dramatically improved, remains a challenge. Experience from clinical practice will be presented using data from the German Biologics register (BiKeR) for evaluation of efficacy and safety of treatment with etanercept (ETA), tocilizumab (TOC) and the interleukin-1 inhibitors anakinra and canakinumab (IL-1i) in sJIA.

Methods: Patients with sJIA documented in the BIKeR register, who were exposed to ETA, TOC or IL-1i were identified. Read More

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November 2017
12 Reads

Ganser Syndrome.

Front Neurol Neurosci 2018 17;42:1-22. Epub 2017 Nov 17.

Laboratory for Cognitive and Neurological Sciences, Département de Médecine, Université de Fribourg, Fribourg, Switzerland.

Ganser's syndrome is a rare and controversial condition, whose main and most striking feature is the production of approximate answers (or near misses) to very simple questions. For instance, asked how many legs a horse has, Ganser patients will reply "5", and answers to plain arithmetic questions will likewise be wrong, but only slightly off the mark (e.g. Read More

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July 2018
5 Reads

Protocols on classification, monitoring and therapy in children's rheumatology (PRO-KIND): results of the working group Polyarticular juvenile idiopathic arthritis.

Pediatr Rheumatol Online J 2017 Nov 7;15(1):78. Epub 2017 Nov 7.

Department of Pediatrics, Prof. Hess Children's Hospital, Bremen, Germany.

Objective: Several effective pharmacologic treatment options for polyarticual juvenile idiopathic arthritis (JIA) have emerged but initial treatment is heterogeneous in Germany. Therefore, the German Society of Pediatric Rheumatolgy has established a commission to develop consensus "Protocols on classification, monitoring and therapy in children's rheumatology (PRO-KIND)" to harmonize diagnostic and treatment approaches for new-onset JIA in Germany.

Methods: A set of definitions for in- and exclusion, diagnostic workup, parameters for the evaluation of disease activity criteria, therapeutic options, medication dosing, monitoring recommendations, targets, definitions of a therapy failure and four therapeutic algorithms developed by a working group were agreed by web based survey to which all members of the GKJR have been invited. Read More

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November 2017
12 Reads

Outcome after relapse of myelodysplastic syndrome and secondary acute myeloid leukemia following allogeneic stem cell transplantation: a retrospective registry analysis on 698 patients by the Chronic Malignancies Working Party of the European Society of Blood and Marrow Transplantation.

Haematologica 2018 Feb 3;103(2):237-245. Epub 2017 Nov 3.

Department of Stem Cell Transplantation, University Hospital Eppendorf, Hamburg, Germany.

No standard exists for the treatment of myelodysplastic syndrome relapsing after allogeneic stem cell transplantation. We performed a retrospective registry analysis of outcomes and risk factors in 698 patients, treated with different strategies. The median overall survival from relapse was 4. Read More

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February 2018
33 Reads

Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO).

Ann Hematol 2017 Dec 31;96(12):1993-2003. Epub 2017 Oct 31.

Department of Internal Medicine III, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients according to age from an academic population-based registry. Adult patients with newly diagnosed AML at 63 centers in Germany and Austria were followed within the AMLSG BiO registry (NCT01252485). Between January 1, 2012, and December 31, 2014, data of 3525 patients with AML (45% women) were collected. Read More

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December 2017
4 Reads

Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy.

Oncotarget 2017 Sep 19;8(43):73871-73883. Epub 2017 May 19.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

The neurotrophins (NTs) play a key role in neuronal survival and maintenance. The TRK (tropomyosin-related kinase) tyrosine kinase receptors (TRKA, TRKB, TRKC) are high affinity receptors for NTs. There is increasing data demonstrating an important role of the TRK family in cancer initiation and progression. Read More

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September 2017
13 Reads

Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions.

Oncotarget 2017 Sep 5;8(43):73483-73500. Epub 2017 Jul 5.

Department of Pathology, Hematopathology Unit and James P Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA.

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of myeloid neoplasms characterized by peripheral cytopenia, dysplasia, and a variable clinical course with about 30% risk to transform to secondary acute myeloid leukemia (AML). In the past 15 years, diagnostic evaluations, prognostication, and treatment of MDS have improved substantially. However, with the discovery of molecular markers and advent of novel targeted therapies, new challenges have emerged in the complex field of MDS. Read More

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September 2017
38 Reads

Usual Care for Maltreatment-Related Pediatric Posttraumatic Stress Disorder in Germany.

Z Kinder Jugendpsychiatr Psychother 2018 03 16;46(2):135-141. Epub 2017 Oct 16.

1 Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Ulm, Ulm, Germany.

Child maltreatment represents a major risk factor for the development of emotional and behavioral problems, especially posttraumatic stress disorder (PTSD). While effective trauma-focused treatments are available, little is known about the usual mental healthcare for abused youths in Germany. The present study compared the utilization of mental healthcare in abused youths who had developed a PTSD (N = 95) with a group presenting other mental disorders (N = 146). Read More

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March 2018
2 Reads

What is the outcome in patients with acute leukaemia who survive severe acute graft-versus-host disease?

J Intern Med 2018 Feb 3;283(2):166-177. Epub 2017 Nov 3.

Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Background: Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (HSCT). With new promising therapies, survival may improve for severe aGVHD.

Objectives: We wanted to analyze the long-term outcome in patients who survive severe aGVHD. Read More

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February 2018
2 Reads

Cost-effectiveness of methods in personalized medicine. Results of a decision-analytic model in patients with acute myeloid leukemia with normal karyotype.

Leuk Res 2017 11 19;62:84-90. Epub 2017 Sep 19.

Institute for Health Care Management and Research, University of Duisburg-Essen, Thea-Leymann-Str. 9, 45127 Essen, Germany.

Background: During the last years, molecular genetic data are increasingly used as prognostic and predictive factors in acute myeloid leukemia (AML). The molecular genetic profile permits a rapid risk categorization and beyond that a prediction of differential treatment efficacy of post-remission chemotherapy versus an allogeneic hematopoietic cell transplantation (HCT) in specific subgroups.

Methods: The aim of this study was to evaluate cost-effectiveness of two different strategies of risk categorization (conventional cytogenetic diagnostics (CCD) versus molecular genetic diagnostics (MGD)) in patients with AML, using a decision-analytic state-transition model. Read More

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November 2017
30 Reads

Predicting death in patients with acute graft-versus-host disease after reduced-intensity conditioning.

Lancet Haematol 2017 09;4(9):e400-e401

Hannover Medical School, Hematology/Oncology, Hannover 30625, Germany.

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September 2017
1 Read

miR-625-3p is upregulated in CD8+ T cells during early immune reconstitution after allogeneic stem cell transplantation.

PLoS One 2017 30;12(8):e0183828. Epub 2017 Aug 30.

Dept. of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Alloreactive CD8+ T-cells mediate the curative graft-versus-leukaemia effect, the anti-viral immunity and graft-versus-host-disease (GvHD) after allogeneic stem cell transplantation (SCT). Thus, immune reconstitution with CD8+ T-cells is critical for the outcome of patients after allogeneic SCT. Certain miRNAs such as miR-146a or miR-155 play an important role in the regulation of post-transplant immunity in mice. Read More

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October 2017
9 Reads

Arthrosonographic Reference Values of the Shoulder Joint in Healthy Children and Adolescents: A Cross-Sectional Multicentre Ultrasound Study.

Klin Padiatr 2017 Sep 24;229(5):293-301. Epub 2017 Aug 24.

Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.

Defining of gray scale ultrasound standard reference values of the shoulder joint in childhood and adolescence during maturation.

Patients: We examined 445 healthy girls and boys between 1 year and 18 years of age. A cross-sectional multicentre grey-scale ultrasound study was performed to examine the shoulder joint on both sides. Read More

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September 2017
32 Reads

RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

Leukemia 2018 01 22;32(1):224-226. Epub 2017 Aug 22.

Department of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.

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January 2018
8 Reads

Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.

Medchemcomm 2017 May 15;8(5):1022-1036. Epub 2017 Mar 15.

Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Diversification of RNA-targeted scaffolds offers great promise in the search for selective ligands of therapeutically relevant RNA such as HIV-1 TAR. We herein report the establishment of amiloride as a novel RNA-binding scaffold along with synthetic routes for combinatorial C(5)- and C(6)-diversification. Iterative modifications at the C(5)- and C(6)- positions yielded derivative , which demonstrated a 100-fold increase in activity over the parent dimethylamiloride in peptide displacement assays. Read More

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May 2017
11 Reads

Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy.

PLoS One 2017 3;12(8):e0181766. Epub 2017 Aug 3.

Clinic for Cardiology and Pneumology, University of Göttingen, Göttingen, Germany.

Background: Patients with retinal vascular occlusion disease have an increased risk for ischemic stroke and share some risk factors with cerebrovascular disease. The purpose of this study was to analyze the prevalence of atrial fibrillation (AF) in subjects with retinal vascular occlusive disease and anterior ischemic optic neuropathy and to compare these data to an ischemic stroke group.

Methods: Prospective, observational single-center trial. Read More

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August 2017
9 Reads

Corrigenda - Models for nearly every occasion: Part II - Two box models.

J Occup Environ Hyg 2017 Aug;14(8):D139

b Exposure Assessment Solutions, Inc. , Morgantown , West Virginia.

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August 2017
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