12,444 results match your criteria Gallbladder Tumors


[Nomenclature correction of "incidental gallbladder cancer" and its prevention strategies].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):490-493

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Incidental gallbladder cancer(IGBC) originated in the West more than half a century ago.IGBC was translated and introduced into China afterwards with widespread clinical application.With the popularization of laparoscopic cholecystectomy, the trend of "abuse" of IGBC has become increasingly apparent worldwide. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200302-00174DOI Listing

Mutation of the Gene, excluding Exon 11, in Gastrointestinal Stromal Tumors.

Biomed Environ Sci 2020 May;33(5):369-373

Departments of Pathology, Liver-Gallbladder-Pancreas Surgery, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.

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http://dx.doi.org/10.3967/bes2020.050DOI Listing

RNA Sequencing Revealed Signals of Evolution From Gallbladder Stone to Gallbladder Carcinoma.

Front Oncol 2020 29;10:823. Epub 2020 May 29.

Department of Biliary Tract Surgery I, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.

Gallbladder stone is a major risk factor for gallbladder carcinoma (GBC), while there is still a controversy whether period of follow-up since newly diagnoses of asymptomatic gallstones increases the risk of GBC. In this study, 10 GBC patients and 30 patients with gallstones were admitted to our hospital. Patients with gallstones were divided into 3 groups according to the follow-up time, involving 10 patients with follow-up period of 1-3 years (GS3 group), 10 patients with follow-up period of 5-10 years (GS5 group), and 10 patients with follow-up period of more than 10 years (GS10 group). Read More

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http://dx.doi.org/10.3389/fonc.2020.00823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272658PMC

[Systemic Chemotherapy of gallbladder carcinoma - simply the same as for cholangiocarcinoma?]

Z Gastroenterol 2020 Jun 16;58(6):583-589. Epub 2020 Jun 16.

Recently published genomic data revealed substantial differences of gallbladder and extrahepatic as well as intrahepatic cholangiocarcinoma. However, these data have no influence on the choice of systemic therapy to date. This review shall provide a concise overview of epidemiology and pathogenesis of gallbladder carcinoma as well as the differences in the mutational profile in comparison to cholangiocarcinoma. Read More

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http://dx.doi.org/10.1055/a-1161-3985DOI Listing

Synchronous detection of SDHA-related gallbladder paraganglioma and pancreatic neuroendocrine tumor.

Pathol Res Pract 2020 Jul 13;216(7):153006. Epub 2020 May 13.

Department of Pathology, Odense Pancreas Center (OPAC), Odense University Hospital, Odense, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Electronic address:

Primary gallbladder paragangliomas (PGLs) are exceedingly rare. PGLs are extraadrenal neuroendocrine tumors that are morphologically inseparable from intraadrenal pheochromocytomas. PGLs and pheochromocytomas are some of the most heritable tumor types in the body and are often associated with other tumors or part of a genetic syndrome. Read More

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http://dx.doi.org/10.1016/j.prp.2020.153006DOI Listing

6-Gingerol exerts anti-inflammatory effects and protective properties on LTA-induced mastitis.

Phytomedicine 2020 May 26;76:153248. Epub 2020 May 26.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China. Electronic address:

Background: Mastitis has a severe impact on human health and breastfeeding. Gram-positive bacteria are one of the most common pathogens, of which lipoteichoic acid (LTA) serves as the main pathogenic factor. Bio-active extractions from herbs is regarded as an alternative method to antibiotics. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153248DOI Listing

Decreased survival of advanced colorectal cancer among patients with chronic cholecystitis: results from two clinical centers.

J BUON 2020 Mar-Apr;25(2):890-898

Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou Province, China.

Purpose: Chronic cholecystitis is a common inflammatory disease of the gallbladder. It is related with various gastrointestinal tumors, although its pathogenesis is not clear. This study was designed to investigate the association between chronic cholecystitis and the survival of patients with advanced colorectal cancer (CRC). Read More

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Deoxycholic acid modulates the progression of gallbladder cancer through N-methyladenosine-dependent microRNA maturation.

Oncogene 2020 Jun 8;39(26):4983-5000. Epub 2020 Jun 8.

Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Bile acids (BAs), well-defined signaling molecules with diverse metabolic functions, play important roles in cellular processes associated with many cancers. As one of the most common BAs, deoxycholic acid (DCA) is originally synthesized in the liver, stored in the gallbladder, and processed in the gut. DCA plays crucial roles in various tumors; however, functions and molecular mechanisms of DCA in gallbladder cancer (GBC) still remain poorly characterized. Read More

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http://dx.doi.org/10.1038/s41388-020-1349-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314665PMC

Gallbladder squamous cell carcinoma: An analysis of 1084 cases from the National Cancer Database.

J Surg Oncol 2020 Jun 8. Epub 2020 Jun 8.

Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Background/objectives: Gallbladder squamous cell carcinoma (SCC) is an uncommon malignancy whose rarity has made it particularly challenging to study. We utilized a national database to shed light on the clinicopathologic characteristics, management patterns, and survival associated with these tumors.

Methods: Patients with gallbladder SCC were identified in the National Cancer Database. Read More

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http://dx.doi.org/10.1002/jso.26066DOI Listing

Duplication of extrahepatic bile duct with lower common bile duct cancer.

J Hepatobiliary Pancreat Sci 2020 Jun 7. Epub 2020 Jun 7.

Department of Internal Medicine, Izumo-city General Medical Center, Izumo, Japan.

A 90-year-old female who previously underwent a cholecystectomy for a gallbladder stone was admitted to our hospital with jaundice. Magnetic resonance cholangiopancreatography (MRCP) revealed left and right bile ducts parallel with the duodenal papilla, and joined distally to form a single short common bile duct with no pancreaticobiliary maljunction (Figure 1). The remnant cystic duct diverged from the right hepatic duct without a common hepatic duct. Read More

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http://dx.doi.org/10.1002/jhbp.779DOI Listing

MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth.

Exp Cell Res 2020 Jun 2:112118. Epub 2020 Jun 2.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Biliary Tract Disease Center of Zhongshan Hospital, Fudan University, Shanghai, China; Biliary Tract Disease Institute, Fudan University, Shanghai, China. Electronic address:

The MUC16 C-terminal (MUC16c) level is associated with tumor serum CA-125 levels, however, the roles remain unclear in gallbladder carcinoma (GBC). In this study, we found that MUC16c promoted glucose uptake and glycolysis for GBC cell proliferation. Mass spectrometry analysis suggested that MUC16c could combine with aldolase. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112118DOI Listing

Circular RNA HIPK3: A Key Circular RNA in a Variety of Human Cancers.

Front Oncol 2020 15;10:773. Epub 2020 May 15.

Hepatic Surgery Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

Circular RNAs (circRNAs), which act as initiators and promoters of various diseases, were thought to be mostly noncoding RNAs (ncRNAs) in eukaryotes, until recent studies confirmed that some circRNAs have the function of encoding proteins. Accumulating research findings have proved that dysregulation of circRNAs is associated with the developmental process of multiple cancers. circHIPK3, an example of circRNA, is frequently expressed in many diseases, such as diabetes, age-related cataract, idiopathic pulmonary fibrosis, preeclampsia, osteoblasts, and retinal vascular dysfunction, leading to disease development and progression. Read More

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http://dx.doi.org/10.3389/fonc.2020.00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242753PMC

[Pathological characteristics and survival analysis of 355 patients with gastroenteropancreatic neuroendocrine neoplasms].

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):426-431

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. In our study, 355 patients pathologically diagnosed as GEP-NENs were identified from April 2006 to November 2017 in the Fourth Hospital of Hebei Medical University. The biological behavior, pathological characteristics and prognosis were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-112152-20191011-00663DOI Listing

Regorafenib after failure of gemcitabine and platinum-based chemotherapy for locally advanced/metastatic biliary tumors: a randomized, double-blind, phase 2 trial - REACHIN.

Ann Oncol 2020 May 25. Epub 2020 May 25.

GE and Digestive Oncology Department, CUB Hôpital Erasme, Brussels, Belgium.

Background: There is a high unmet clinical need for treatments for advanced/metastatic biliary tract cancers (BTC) after progression on first-line chemotherapy. Regorafenib has demonstrated efficacy in some gastrointestinal tumors that progress on standard therapies.

Patients And Methods: REACHIN was a multicenter, double-blind, placebo-controlled, randomized phase 2 study designed to evaluate the safety and efficacy of regorafenib in patients with nonresectable/metastatic BTC that progressed after gemcitabine/platinum chemotherapy. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.05.018DOI Listing

Desmin dysregulation in gall bladder cancer.

Authors:
Balraj Mittal

Indian J Med Res 2020 04;151(4):273-274

Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226 025, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/ijmr.IJMR_1540_19DOI Listing

Effect of lymphadenectomy in curative gallbladder cancer treatment: a systematic review and meta-analysis.

Langenbecks Arch Surg 2020 May 26. Epub 2020 May 26.

Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007, St. Gallen, Switzerland.

Purpose: Only a small fraction of resectable gallbladder cancer (GBC) patients receive a thorough lymphadenectomy. The aim of this systematic review and meta-analysis was to investigate the effect of lymphadenectomy on survival in GBC surgery.

Methods: On May 19, 2019, MEDLINE, EMBASE, and the Cochrane Library were searched for English or German articles published since 2002. Read More

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http://dx.doi.org/10.1007/s00423-020-01878-zDOI Listing

Laparoscopic and endoscopic cooperative surgery for cholecystogastric fistula: A case report.

Authors:
Goshi Fujimoto

Int J Surg Case Rep 2020 15;71:116-119. Epub 2020 May 15.

Department of Gastroenterological Surgery, Ofuna Chuo Hospital, 6-2-24, Ofuna, Kamakura, Kanagawa 247-0056, Japan. Electronic address:

Introduction: Cholecystoenteric fistula (CEF) is rare in biliary tract surgery, and cholecystogastric fistula (CGF) is the rarest form of CEF. Although open cholecystectomy with the closure of the fistula is the gold standard treatment for nonobstructing biliary-enteric fistulas, the optimal treatment for CGF has not been established. Laparoscopic and endoscopic cooperative surgery (LECS), a minimally invasive surgery for gastric submucosal tumors, reportedly helps achieve favorable postoperative outcomes. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242993PMC

Oncologic safety of laparoscopic radical cholecystectomy in pT2 gallbladder cancer: A propensity score matching analysis compared to open approach.

Medicine (Baltimore) 2020 May;99(20):e20039

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine.

The role of laparoscopic radical cholecystectomy (LRC) in the surgical management of T2 gallbladder carcinoma (GBC) is still controversial.The medical records of patients with T2 GBC treated with radical cholecystectomy were retrospectively reviewed. In this study, we compare the short- and long-term oncologic outcomes, using propensity score matching analysis, of patients with T2 GBC who underwent LRC and open radical cholecystectomy (ORC). Read More

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http://dx.doi.org/10.1097/MD.0000000000020039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253605PMC

Gallbladder osteoma in a 66-year-old female; Case report and review of literature.

Int J Surg Case Rep 2020 1;70:37-39. Epub 2020 Apr 1.

Hospital Angeles Lomas, Department of Surgery, Edo. Mex 52763, Mexico.

Introduction: Gallbladder mesenchymal tumours are rare. The more common include fibroma, lipoma or haemangioma. A gallbladder osteoma is very rare indeed there is only one other case reported in medical literature). Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218224PMC

Deciphering the Roles of IFITM1 in Tumors.

Mol Diagn Ther 2020 May 11. Epub 2020 May 11.

Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, P.R. China.

Interferon (IFN)-induced transmembrane protein 1 (IFITM1), a member of the IFN-induced transmembrane protein family, is reported to be highly expressed in tumor tissues as well as cancer cell lines, and it is an independent prognostic biomarker for patients with certain tumor types, such as gallbladder carcinoma, esophageal adenocarcinoma, colorectal cancer, and gastric cancer. Moreover, overexpression of IFITM1 promotes tumor cell proliferation, invasion, metastasis, angiogenesis, and therapeutic resistance, including endocrine therapy, chemotherapy, and radiotherapy resistance. Due to these diverse functions of IFITM1 in tumors, targeting IFITM1 may provide a novel strategy for cancer treatment and be highly desirable to improve cancer patient outcomes. Read More

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http://dx.doi.org/10.1007/s40291-020-00469-4DOI Listing

Phase I study of DFP-11207, a novel oral fluoropyrimidine with reasonable AUC and low C and improved tolerability, in patients with solid tumors.

Invest New Drugs 2020 May 6. Epub 2020 May 6.

Delta-Fly Pharma, Inc., Tokushima, Japan.

5-fluorouracil (5-FU) and 5-FU derivatives, such as capecitabine, UFT, and S-1, are the mainstay of chemotherapy treatment for gastrointestinal cancers, and other solid tumors. Compared with other cytotoxic chemotherapies, these drugs generally have a favorable safety profile, but hematologic and gastrointestinal toxicities remain common. DFP-11207 is a novel oral cytotoxic agent that combines a 5-FU pro-drug with a reversible DPD inhibitor and a potent inhibitor of OPRT, resulting in enhanced pharmacological activity of 5-FU with decreased gastrointestinal and myelosuppressive toxicities. Read More

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http://dx.doi.org/10.1007/s10637-020-00939-wDOI Listing

Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Front Oncol 2020 21;10:536. Epub 2020 Apr 21.

Clinical Cancer Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Comprehensive Genomic Profiling may be informative for novel treatment strategies and to improve outcomes for patients with rare tumors. This study aims to discover opportunities for use of targeted therapies already approved for routine use in patients with rare tumors. Solid tumors with an incidence lower than 2. Read More

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http://dx.doi.org/10.3389/fonc.2020.00536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186305PMC

Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.

Health Technol Assess 2020 Apr;24(21):1-38

Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.

Background: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no adequately powered trials comparing surgery with thermal ablation.

Objectives: Main objective - to compare the clinical effectiveness and cost-effectiveness of thermal ablation versus liver resection surgery in high surgical risk patients who would be eligible for liver resection. Read More

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http://dx.doi.org/10.3310/hta24210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232132PMC

Gallbladder Neuroendocrine Carcinoma: A Rare Endocrine Tumor.

Cureus 2020 Mar 31;12(3):e7487. Epub 2020 Mar 31.

Internal Medicine, Indiana University Health, Indianapolis, USA.

Gallbladder neuroendocrine neoplasms (GB-NEN) are very rare neuroendocrine tumors (NETs). GB-NEN can present as carcinoid or typical/atypical carcinoid or small cell carcinoma. Most of the GB-NENs present as gall bladder polyps or stones with right upper quadrant pain, nausea and non-specific symptoms which leads to clinical misdiagnosis. Read More

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http://dx.doi.org/10.7759/cureus.7487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192559PMC

Meta-analysis of randomized clinical trials of adjuvant chemotherapy for resected biliary tract cancers.

HPB (Oxford) 2020 Apr 26. Epub 2020 Apr 26.

Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Background: This meta-analysis was performed by analyzing randomized controlled trials (RCTs) to assess the potential prognostic value of adjuvant chemotherapy (ACT) for patients with resected biliary tract cancers (BTCs).

Methods: PubMed, EMBASE, and the Cochrane Library were searched for relevant articles published. Only RCTs affected by tumors of gallbladder, intrahepatic, perihilar, and distal bile ducts were considered. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.02.001DOI Listing

Should jaundice preclude resection in patients with gallbladder cancer? Results from a nation-wide cohort study.

HPB (Oxford) 2020 Apr 24. Epub 2020 Apr 24.

Department of Surgery, Radboudumc, P.O. Box 9101, Internal Code 618, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Background: It is controversial whether patients with gallbladder cancer (GBC) presenting with jaundice benefit from resection. This study re-evaluates the impact of jaundice on resectability and survival.

Methods: Data was collected on surgically explored GBC patients in all Dutch academic hospitals from 2000 to 2018. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.03.015DOI Listing

Smac mimetic promotes TNF-α to induce apoptosis of gallbladder carcinoma cells.

Cell Signal 2020 Aug 22;72:109654. Epub 2020 Apr 22.

Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fujian Medical University, Fuzhou, China; Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumour Microbiology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. Electronic address:

Gallbladder carcinoma has a high degree of malignancy. No effective treatment exists for patients with advanced tumors. The second mitochondria-derived activator of caspases (Smac) is the antagonist of the inhibitors of apoptosis protein. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109654DOI Listing

Gallbladder GIST: A review of literature.

Authors:
Ashish Gupta

Pol Przegl Chir 2019 Nov;92(1):34-37

Department of Surgery, All India Institute of Medical Sciences, Rishikesh, India.

Mesenchymal tumors of the gallbladder are rarely encountered in clinical practice. The Gastrointestinal Stromal Tumor (GIST) of the gallbladder is rarely encountered. These tumors most commonly arise from the interstitial cells of Cajal (ICC), the pacemakers of the intestinal system. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5550DOI Listing
November 2019

Ancient Schwannoma of the Gallbladder.

ACG Case Rep J 2020 Feb 28;7(2):e00330. Epub 2020 Feb 28.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, VU University Amsterdam, Amsterdam, Netherlands.

Schwannomas are benign tumors which arise in the Schwann cells of the peripheral nerves. They develop anywhere in the human body but are less frequent found in the digestive tract. A 67-year-old female patient was referred to our tertiary HPB department with a asymptomatic mass of the gallbladder. Read More

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http://dx.doi.org/10.14309/crj.0000000000000330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145185PMC
February 2020

A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer.

Onco Targets Ther 2020 3;13:2855-2872. Epub 2020 Apr 3.

Center for Drug Metabolism and Pharmacokinetics, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, People's Republic of China.

MicroRNAs (miRNAs) are a class of endogenous non-coding single-stranded small-molecule RNAs that regulate gene expression by repressing target messenger RNA (mRNA) translation or degrading mRNA. miR-34a is one of the most important miRNAs participating in various physiological and pathological processes. miR-34a is abnormally expressed in a variety of tumors. Read More

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http://dx.doi.org/10.2147/OTT.S234549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138617PMC

Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.

Surgery 2020 Jun 14;167(6):950-956. Epub 2020 Apr 14.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Few reports have addressed postoperative infectious complications caused by multidrug-resistant pathogens. The aim of this study was to review the surgical outcomes of patients undergoing major hepatectomy with extrahepatic bile duct resection and to clarify the incidence of and the risk factors for postoperative infectious complications caused by multidrug-resistant pathogens.

Methods: Medical records of consecutive patients who underwent major hepatectomy with extrahepatic bile duct resection between 2006 and 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.surg.2020.02.015DOI Listing

Diagnostic Approach to Benign and Malignant Calcifications in the Abdomen and Pelvis.

Radiographics 2020 May-Jun;40(3):731-753. Epub 2020 Apr 17.

From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110.

Intra-abdominal calcifications are common. Multiple pathologic processes manifest within the abdomen and pelvis in association with calcifications, which can be benign, premalignant, or malignant. Although calcium deposition in the abdomen can occur secondary to various mechanisms, the most common cau se is cellular injury that leads to dystrophic calcifications. Read More

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http://dx.doi.org/10.1148/rg.2020190152DOI Listing

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.

Biol Res 2020 Apr 15;53(1):13. Epub 2020 Apr 15.

Department of Pathology, Faculty of Medicine, Millennium Institute of Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC represents the second cause of cancer-related death among women. Read More

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http://dx.doi.org/10.1186/s40659-020-00282-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158131PMC

Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort.

Cancers (Basel) 2020 Apr 9;12(4). Epub 2020 Apr 9.

Department of Surgery, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.

Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a low-incidence country. GBC patients diagnosed between 2005 and 2016 with GBC were identified from the Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.3390/cancers12040918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226578PMC

Neuroendocrine tumors of the gallbladder.

Oncol Lett 2020 May 12;19(5):3381-3388. Epub 2020 Mar 12.

Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

A gallbladder neuroendocrine neoplasm (GB-NEN) is a unique heterogeneous neoplasm, originating from neuroendocrine cells and able to secrete peptides as its neurotransmitter. Among all the neuroendocrine tumors (NETs), the GB-NEN prevalence is 0.5%, which accounts for ~2. Read More

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http://dx.doi.org/10.3892/ol.2020.11461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115111PMC

ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.

Int J Clin Oncol 2020 Jul 5;25(7):1346-1355. Epub 2020 Apr 5.

Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.

Background: Squamous cell/adenosquamous carcinoma (SC/ASC) is a rarely identified form of gallbladder cancer with poorly understood clinical features. As such, there is an urgent need to identify novel prognostic biomarkers for such gallbladder SC/ASC cases, and for gallbladder adenocarcinomas (ACs).

Methods: The levels of ACO2 and ANPEP proteins were assessed via an EnVision-based immunohistochemical approach using 46 SC/ASC and 80 AC patient samples. Read More

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http://dx.doi.org/10.1007/s10147-020-01651-8DOI Listing

[Analysis of the relationship between the number of lymph nodes examined and prognosis for curatively resected gallbladder carcinoma: a multi-institutional study].

Zhonghua Wai Ke Za Zhi 2020 Apr;58(4):303-309

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

To examine the role of the number of lymph nodes examined(NLNE) on the prognosis of patients with curatively resected gallbladder carcinoma(GBC). The clinicopathological data and prognosis of 401 patients with GBC who underwent radical surgery from six institutions of China from January 2013 to December 2017 were analyzed retrospectively. There were 153 males(38. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200119-00042DOI Listing

[Guideline for the diagnosis and treatment of gallbladder carcinoma (2019 edition)].

Authors:

Zhonghua Wai Ke Za Zhi 2020 Apr;58(4):243-251

In order to improve the overall therapeutic effect of gallbladder cancer in China, Branch of Biliary Surgery, Chinese Surgical Society and Chinese Committee of Biliary Surgeons have formulated the guideline for the diagnosis and treatment of gallbladder carcinoma (2019 edition) . The guideline provided an overview of the evidence on epidemiological risk factors, treatment and follow-up strategies for patients with gallbladder cancer.It also updated the new TNM stage and proposed the clinical classification of gallbladder cancer for the first time. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200106-00014DOI Listing

Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer.

J Cancer 2020 4;11(11):3114-3123. Epub 2020 Mar 4.

Department of General Surgery, Suzhou Ninth People's Hospital, Suzhou, China.

Gallbladder cancer is one of the most common malignant tumors in the biliary tract. In recent years, the chemotherapy treatment for gallbladder carcinoma has exhibited obvious characteristics of drug resistance and insensitivity, and one of the main factors is the existence of cancer stem cells. Here in this study, the effect of Bufalin on gallbladder cancer (GBC-SD) cells and the related mechanism were studied. Read More

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http://dx.doi.org/10.7150/jca.38393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097950PMC
March 2020
2.639 Impact Factor

Triphasic dynamic contrast-enhanced computed tomography predictive model of benign and malignant risk of gallbladder occupying lesions.

Medicine (Baltimore) 2020 Mar;99(13):e19539

Department of General Surgery.

Gallbladder occupying lesions are common diseases of biliary system. Among them, gallbladder cancer is difficult to diagnose due to the indistinguishable early symptoms, thus posing a great risk to the population. This study aims to establish a computed tomography (CT) prediction model for distinguishing benign and malignant lesions of gallbladder occupying lesions. Read More

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http://dx.doi.org/10.1097/MD.0000000000019539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220315PMC

Hepatobiliary cancers and immunotherapy: where are we now and where are we heading?

Transl Gastroenterol Hepatol 2020 5;5. Epub 2020 Jan 5.

Division of Hematology/Oncology, The Warren Alpert Medical School of Brown University/Lifespan Cancer Institute, Rhode Island Hospital, Providence, RI, USA.

Primary liver cancers are a heterogenous collection of diseases with variable natural histories and treatments. This review article will focus on hepatocellular carcinoma (HCC), intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder cancer, and the use of immune checkpoint inhibitors (ICIs) in their treatment. This will include the currently studied, approved uses as well as the potential future roles of ICIs in the treatment of cancers of the hepatobiliary system through recent updates on ongoing studies and discussion of phase III studies underway. Read More

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http://dx.doi.org/10.21037/tgh.2019.09.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061229PMC
January 2020

Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine.

JHEP Rep 2020 Apr 16;2(2):100068. Epub 2020 Jan 16.

Department of Surgery, Mayo Clinic, Rochester, MN.

Background & Aims: Biliary tract tumors are uncommon but highly aggressive malignancies with poor survival outcomes. Due to their low incidence, research into effective therapeutics has been limited. Novel research platforms for pre-clinical studies are desperately needed. Read More

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http://dx.doi.org/10.1016/j.jhepr.2020.100068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066236PMC

Insights into the role of tumor abnormal protein in early diagnosis of cancer: A prospective cohort study.

Medicine (Baltimore) 2020 Mar;99(11):e19382

Department of Oncology, Xi'an International Medical Center, Xi'an, Shaanxi, China.

The aim of this study was to evaluate the clinical use of tumor abnormal protein (TAP) in the diagnosis of different cancers.Totally 394 patients were divided into 4 groups, namely 100 healthy volunteers, 167 patients with cancer, 20 subjects with precancerous lesions, and 107 subjects with benign lesions. TAP was detected in 4 groups of research subjects using a TAP testing kit and examination system. Read More

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http://dx.doi.org/10.1097/MD.0000000000019382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220304PMC

[A case of mass-forming chronic pancreatitis with amputation neuroma-like neurogenesis of the bile duct].

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(3):261-269

Department of Pathology, Ehime Prefectural Central Hospital.

A man in his 40s visited a facility with the chief complaint of abdominal pain;liver dysfunction was detected, and consequently, he was referred to our hospital for further examinations. His medical history was unremarkable. He used to drink alcohol (beer, 1500mL) every day. Read More

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http://dx.doi.org/10.11405/nisshoshi.117.261DOI Listing

[Neoadjuvant Proton Beam Chemoradiotherapy for Locally Advanced Gall Bladder Cancer-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):1975-1977

Dept. of Surgery, Tannan Regional Medical Center.

A 67-year-old man visited our hospital due to progressing appetite loss and fever. He presented with a fist-sized palpable mass in his right hypochondrium. Abdominal CT showed a 10 cm diameter tumor that originated from the gall bladder infiltrating the abdominal wall, liver, duodenum, and colon. Read More

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December 2019

[Undifferentiated Carcinoma of the Gallbladder with Rapid Postoperative Progression-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2524-2526

Dept. of Hepato-Biliary-Pancreatic Surgery, Osaka City General Hospital.

A 74-year-old woman presented with epigastric pain. Imaging revealed a tumor measuring 80 mm, with internal necrosis, originating from the gallbladder and invading the liver. We performed extended anterior segmentectomy of the liver and lymph node resection following a preoperative diagnosis of gallbladder cancer. Read More

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December 2019

[A Case of Gallbladder Metastasis from Breast Cancer with Acute Calculous Cholecystitis].

Gan To Kagaku Ryoho 2019 Dec;46(13):2294-2296

Dept. of Gastrointestinal Surgery, Osaka City General Hospital.

In June 2018, a 75-year-old woman was admitted for right upper quadrant pain. She had a history of radical mastectomy for left breast cancer in April 2009. The axillary lymph node, bone, gastric, and pleural metastases had been treated with hormonal therapy for 2 years from April 2016. Read More

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December 2019

[A Case of Successful Surgical Treatment for Paraaortic Lymph Nodes Recurrence of Gallbladder Cancer].

Gan To Kagaku Ryoho 2019 Dec;46(13):2261-2263

Dept. of Surgery and Gastrointestinal Surgery, Itami City Hospital.

Cholecystectomy with gallbladder bed resection and regional lymphadenectomy was performed in a 75-year-old man with advanced gallbladder cancer. Pathological examination revealed adenocarcinoma in the gallbladder with regional lymph node metastases. Cancer recurrence was found in paraaortic lymph nodes behind the duodenum 9 months after the surgery. Read More

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December 2019

[A Case of Recurrent Gallbladder Carcinoma Treated with Resection and Hepatic Arterial Infusion].

Gan To Kagaku Ryoho 2019 Dec;46(13):2258-2260

Dept. of Surgery, Munakata Suikokai General Hospital.

A 69-year-old woman underwent extended cholecystectomy for gallbladder cancer[T2N0M0, fStage Ⅱ(UICC 7th edition)]. She was then administered adjuvant S-1 and was treated for drug-induced neutropenia. One year later, recurrent lesions were detected in liver S4 and S5. Read More

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December 2019