11,845 results match your criteria Gallbladder Tumors


Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.

J Gastrointest Surg 2019 Feb 12. Epub 2019 Feb 12.

Section of Hepatobiliary and Pancreatic Surgery, Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Background: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease.

Materials And Methods: We maintain a prospective high volume gastrointestinal malignancy PDX program. Read More

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http://dx.doi.org/10.1007/s11605-019-04109-zDOI Listing
February 2019

"-Omas" presenting as "-itis": acute inflammatory presentations of common gastrointestinal neoplasms.

Emerg Radiol 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Oncologic emergencies have a high rate of morbidity and mortality. This review covers several scenarios of gastrointestinal malignancies presenting emergently as various acute abdominal pathologies. Radiologists should be familiar with the typical imaging findings, clinical presentations, and laboratory values which may suggest a background neoplasm, particularly when encountered in the context of an acute inflammatory state. Read More

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http://dx.doi.org/10.1007/s10140-019-01678-zDOI Listing
February 2019
1 Read

Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report.

Surg Case Rep 2019 Feb 4;5(1):17. Epub 2019 Feb 4.

Department of Surgery, Maizuru Medical Center, Kyoto, Japan.

Background: Metastases to the stomach or gallbladder from any malignancy is rarely noted, and simultaneous metastases to both organs are atypical. We present a unique case of simultaneous multifocal metastases of the stomach and gallbladder from renal cell carcinoma (RCC).

Case Presentation: The case involved a 60-year-old man, with a past history of RCC (clear cell type, G2, T1b N0 M0 Stage I) treated by a right nephrectomy. Read More

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http://dx.doi.org/10.1186/s40792-019-0569-xDOI Listing
February 2019
1 Read

Incidental versus non-incidental gallbladder cancer: index cholecystectomy before oncologic re-resection negatively impacts survival in T2b tumors.

HPB (Oxford) 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Conflicting data exists whether non-oncologic index cholecystectomy (IC) leading to discovery of incidental gallbladder cancer (IGBC) negatively impacts survival. This study aimed to determine whether a subgroup of patients derives a disadvantage from IC.

Methods: Patients with IGBC and non-IGBC treated at an academic USA and Chilean center during 1999-2016 were compared. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.12.006DOI Listing
January 2019
1 Read

Uncommon Intraluminal Tumors of the Gallbladder and Biliary Tract: Spectrum of Imaging Appearances.

Radiographics 2019 Feb 1:180164. Epub 2019 Feb 1.

From the Departments of Radiology (A.C., C.L.V., P.N., N.A.H., V.Y., F.H.M.) and Pathology (A.J.B., G.Y.Y.), Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 800, Chicago, IL 60611; Department of Radiology, Emory University School of Medicine, Atlanta, Ga (P.K.M.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

Intraluminal pathologic conditions of the bile ducts and gallbladder are common, most frequently consisting of calculi and adenocarcinoma. In recent years, intraductal papillary neoplasm of the bile ducts (IPN-B), which is analogous to intraductal papillary mucinous neoplasm of the pancreas, has been recognized as a distinct pathologic entity and a precursor lesion to adenocarcinoma of the bile ducts. Intraductal tubulopapillary neoplasm (ITPN) of the bile duct was subsequently described as a distinct pathologic entity. Read More

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http://dx.doi.org/10.1148/rg.2019180164DOI Listing
February 2019
2 Reads

Role of digital single-operator cholangioscopy in the diagnosis and treatment of biliary disorders.

World J Gastrointest Endosc 2019 Jan;11(1):31-40

Department of Interventional Gastroenterology, Clinic of Gastroenterology, Acibadem City Clinic Tokuda Hopsital, Sofia 1407, Bulgaria.

Due to the need for improvement in the diagnosis and minimally invasive therapy of the bile duct disorders new technologies for cholangioscopy have been recently developed. Per-oral cholangioscopy has become an important diagnostic and therapeutic tool leading to avoidance of aggressive and unnecessary surgery in many clinical scenarios. This paper focuses on the newly developed SpyGlass DS technology, its advantages, and the technique of single-operator cholangioscopy (SOC), biliary indications and possible adverse events. Read More

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http://dx.doi.org/10.4253/wjge.v11.i1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354115PMC
January 2019
1 Read

Positive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator.

Eur J Surg Oncol 2019 Jan 24. Epub 2019 Jan 24.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Prognostic factors following index-cholecystectomy in patients with incidental gallbladder cancer (IGBC) are poorly understood. The aim of this study was to assess the value of the initial cystic duct margin status as a prognosticator factor and to aid in clinical decision making to move forward with curative intent oncologic extended resection (OER).

Methods: This retrospective study included patients with IGBC who underwent subsequent OER with curative intent at 2 centers (USA and Chile) between 1999 and 2016. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.013DOI Listing
January 2019
1 Read

Outcomes of surgery for gallbladder cancer: A single-center experience.

North Clin Istanb 2018 Sep;5(3):195-198

Department of Surgery, Inonu University Institute of Liver Transplantation, Malatya, Turkey.

Objective: Gallbladder cancer (GBC) is a rare clinical entity that has a poor prognosis. Radical resection with meticulous lymph node dissection is the only treatment option. The aim of the present study is to evaluate the efficacy of radical resection for GBC in the early postoperative period with the viewpoint of clinicopathological correlation. Read More

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http://dx.doi.org/10.14744/nci.2017.69320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323569PMC
September 2018
2 Reads

Efficacy and Safety of Microwave Ablation (MWA) for Hepatocellular Carcinoma (HCC) in Difficult Anatomical Sites in Egyptian Patients with Liver Cirrhosis

Asian Pac J Cancer Prev 2019 Jan 25;20(1):295-301. Epub 2019 Jan 25.

Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. Email:

Background and aim: Imaging guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) has become a widely used method over recent years. Tumors close to the diaphragm, gastrointestinal tract, gallbladder, pancreas, hepatic hilum and major bile duct or vessels are generally considered relative contraindications for microwave ablation. This study was conducted to assess the effectiveness and safety of ultrasonography-guided MWA in treating patients with HCC in difficult anatomical sites in comparison to those in conventional sites. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.295DOI Listing
January 2019
1 Read

An atlas for clinical target volume definition, including elective nodal irradiation in definitive radiotherapy of biliary cancer.

Oncol Lett 2019 Feb 28;17(2):1784-1790. Epub 2018 Nov 28.

Radiation Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, I-40138 Bologna, Italy.

Radiotherapy (RT) is a treatment option for advanced biliary tract cancer (BTC), often combined with sequential and/or concurrent chemotherapy. The use of modern RT techniques requires accurate clinical target volume (CTV) definition and delineation. However, guidelines for CTV delineation in BTC are lacking. Read More

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http://dx.doi.org/10.3892/ol.2018.9774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341831PMC
February 2019
1 Read

Decreased liver stiffness by transient elastography indicates lower incidence of hepatocellular carcinoma in patients with chronic hepatitis B.

Medicine (Baltimore) 2019 Jan;98(3):e13929

Department of Gastroenterology, Jining No 1 People's Hospital, Jining, Shandong.

The prognositc value of dynamic liver stiffness (LS) variation on hepatocellular carcinoma (HCC) incidence in patients with chronic hepatitis B (CHB) remains to be explored. We aim to compare HCC incidence in patients with compensated CHB-related cirrhosis with increased and decreased LS after nucleos(t)ide analog (NA) regimens.A total of 168 patients with CHB-related compensated cirrhosis were divided into groups according to LS variation post to NA treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000013929DOI Listing
January 2019
8 Reads

Safety of transarterial radioembolization with Yttrium-90 glass microspheres without cystic artery occlusion.

Radiol Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Nuclear Medicine, Yeditepe University Hospital, 34752, Atasehir, Istanbul, Turkey.

Purpose: To assess radiation-induced cholecystitis in cases of cystic artery origin nearby the treatment zone for transarterial radioembolization (TARE) treatment.

Materials And Methods: Patients with primary or secondary malignant liver tumors treated with TARE, in whom cystic artery was located in the surrounding area of the treatment zone on 99m-technetium-MAA angiograms, were included in this study. Whole liver dose, tumor dose and healthy injected liver dose, lung dose and if applicable the gallbladder dose were all calculated by using the Medical Internal Radiation Dose (MIRD) formula from SPECT-CT images. Read More

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http://dx.doi.org/10.1007/s11547-018-00984-9DOI Listing
January 2019
1 Read

Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study.

World J Surg Oncol 2019 Jan 7;17(1). Epub 2019 Jan 7.

Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of Medicine, 79, Gangnam-ro, Jinju, 660-702, South Korea.

Background: While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC.

Methods: Data of 81 patients with histopathologically proven T2 GBC who underwent surgical resection between January 1999 and December 2017 were enrolled from a retrospective database. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1556-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323785PMC
January 2019
7 Reads

KML001, an arsenic compound, as salvage chemotherapy in refractory biliary tract cancers: A prospective study.

Hepatobiliary Pancreat Dis Int 2019 Feb 28;18(1):62-66. Epub 2018 Dec 28.

Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Electronic address:

Background: Sodium meta-arsenite (NaAsO, KML001) is a potential oral anticancer agent acting on telomerase and telomere length. This prospective study evaluated its safety, tolerability, and effectiveness as salvage chemotherapy in patients with advanced biliary tract cancer (BTC) resistant to gemcitabine-based chemotherapy.

Methods: Forty-four patients (21 women and 23 men) with advanced BTC and failure history of gemcitabine-based chemotherapy, performance status (PS) 0-2, normal cardiac, hepatic, and renal function were enrolled. Read More

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http://dx.doi.org/10.1016/j.hbpd.2018.12.009DOI Listing
February 2019
3 Reads

Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin.

BMC Cancer 2019 Jan 5;19(1):10. Epub 2019 Jan 5.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.

Background: Gallbladder cancer (GBC) is likely to be diagnosed at progressive stages and shows a very poor prognosis. Combination therapy with gemcitabine and cisplatin (GEMCIS) has been widely used as first-line palliative chemotherapy for advanced GBC. This study was designed to investigate the efficacy of GEMCIS and identify prognostic factors in patients with unresectable GBC. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5211-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321682PMC
January 2019
6 Reads

Neuroendocrine carcinomas of the gallbladder: Lessons learnt from cases at opposite ends of the spectrum.

J BUON 2018 Nov-Dec;23(6):1922-1926

Department of Surgery, Duke University Hospital, Durham, NC, USA.

Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which represents about 0.5% of all gallbladder carcinomas and 0. Read More

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January 2019
1 Read

[Report of incidence and mortality of gallbladder cancer in China, 2014].

Zhonghua Zhong Liu Za Zhi 2018 Dec;40(12):894-899

the Project Office of Early Detection and Treatment of Cancer in Urban China, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

The incidence and mortality of gallbladder cancer from Chinese cancer registries in 2014 were analyzed to describe the prevalence of gallbladder cancer in China. Incidence and mortality data of gallbladder cancer in 2014 derived from registration data in 2017, collected by the National Central Cancer Registry (NCCR). Qualified data from 339 cancer registries were calculated after evaluating. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.12.004DOI Listing
December 2018
12 Reads

An autopsy case of primary extranodal NK/T cell lymphoma (extranodal NK/T-cell lymphoma) of the bile duct.

Clin J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology, Tokai University Hachioji Hospital, Tokyo, Japan.

We reported the case of a 50-year-old man diagnosed with extrinsic NK/T-cell lymphoma. He was initially diagnosed with locally advanced unresected pancreatic duct carcinoma and was treated with combination chemotherapy using gemcitabine and nabpaclitaxel. One month after treatment, he developed bleeding. Read More

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http://link.springer.com/10.1007/s12328-018-00931-1
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http://dx.doi.org/10.1007/s12328-018-00931-1DOI Listing
January 2019
10 Reads

Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 25;2018:6124927. Epub 2018 Nov 25.

Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Orthopaedic Department, China-Japan Friendship Hospital, Chaoyang District, Beijing, China.

Background: Previous literatures have investigated the change of miR-20a expression level in the progression of multiple cancers and its influence on patients' survival outcome, but results of now-available evidence are inconsistent.

Objective: To elucidate the prognostic value of circulating and tissue-based miR-20a for patients with various cancers.

Methods: A systematic search and review of eligible publications were carried out in three electronic databases including the Cochrane Library, PubMed, and Embase, and the methodological quality of included studies was assessed according to Newcastle-Ottawa Scale (NOS). Read More

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http://dx.doi.org/10.1155/2018/6124927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286746PMC
November 2018
7 Reads

Positive relationship between number of negative lymph nodes and duration of gallbladder cancer cause-specific survival after surgery.

Cancer Manag Res 2018 13;10:6961-6969. Epub 2018 Dec 13.

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, China,

Background: Although the prognostic implications of negative lymph nodes (NLNs) has been reported for a variety of tumors, little information has been published about the NLNs in gallbladder cancer (GBC).

Patients And Methods: In this study, clinicopathological characteristics and survival times of patients who had undergone surgery for GBC were collected from the Surveillance, Epidemiology, and End Results Program-registered TNM stage database and analyzed. Univariate and multivariate Cox proportional hazards models were used to identify the predictors of survival. Read More

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http://dx.doi.org/10.2147/CMAR.S187857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300379PMC
December 2018
1 Read

Staging laparoscopy among three subtypes of extra-hepatic biliary malignancy: a 15-year experience from 10 institutions.

J Surg Oncol 2019 Mar 26;119(3):288-294. Epub 2018 Dec 26.

Department of Surgery, Barnes-Jewish Hospital, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

Background: Staging laparoscopy (SL) is used to avoid resection failure and thus increase the curative resection rate. SL utilization in extra-hepatic biliary tumors (EHBT) is variable.

Methods: Data from 1090 patients with potentially resectable EHBT including gallbladder (GBC), distal (DC), and hilar (HC) subtypes were retrospectively collected from 10 academic centers (2000-2015). Read More

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http://dx.doi.org/10.1002/jso.25323DOI Listing
March 2019
2 Reads

Progression of immunoglobulin G4-related disease to systematic lupus erythematosus after gastric cancer surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13545

Department of Nephrology, Fujita Health University School of Medicine.

Rationale: Immunoglobulin G4 related disease (IgG4-RD) rarely coexists with other autoimmune diseases, though we had a patient whose primary clinical problem was shifted from IgG4-RD to systemic lupus erythematosus (SLE) after gastrectomy. The present paper aimed to report pathological findings and clinical course of the patient.

Patient Concerns: The patient was a male aged 74 years old with gastric cancer characterized by the following symptoms: Raynaud phenomenon, polyarthralgia, and swollen parotid glands on both sides. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0003
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http://dx.doi.org/10.1097/MD.0000000000013545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320217PMC
December 2018
3 Reads

A Resected Gallbladder Carcinoma Coexisting With Adenomyomatosis Involving Varied Degrees of Intraepithelial Dysplasia: A Case Report and Literature Review.

Surg Laparosc Endosc Percutan Tech 2018 Dec 18. Epub 2018 Dec 18.

Department of Clinical Pathology, Kitasato Institute Hospital, Tokyo, Japan.

A 59-year-old asymptomatic man underwent ultrasonography, which revealed gallstones and thickened gallbladder wall. Abdominal computed tomography (CT) showed a slightly swollen bilocular gallbladder and a soft tissue mass in the fundus site. Segmental adenomyomatosis (ADM) was suspected because numerous fundic cystic lesions were seen on magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000617DOI Listing
December 2018
1 Read

Nomogram to predict overall survival after gallbladder cancer resection in China.

World J Gastroenterol 2018 Dec;24(45):5167-5178

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Aim: To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma (GBC) into a predictive nomogram.

Methods: One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital (PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) in China from January 1, 2003 to January 1, 2018. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i45/5167.htm
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http://dx.doi.org/10.3748/wjg.v24.i45.5167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288645PMC
December 2018
6 Reads

Hepatic Sclerosing Hemangioma Simulating Gallbladder Carcinoma: A Rare Case.

J Clin Exp Hepatol 2018 Dec 19;8(4):474-477. Epub 2018 Jul 19.

Icahn School of Medicine at Mount Sinai, Department of Pathology New York, NY, USA 10029-6574.

Sclerosing hemangiomas of the liver are rare benign tumors of the liver. Although hepatic hemangiomas are the most common benign liver tumor, they are mostly cavernous in nature. A hepatic sclerosing hemangioma is defined by presence of fibrosis and hyalinization as a result of degenerative changes in a cavernous hemangioma. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286440PMC
December 2018
1 Read

A phase 2 trial of regorafenib as a single agent in patients with chemotherapy-refractory, advanced, and metastatic biliary tract adenocarcinoma.

Cancer 2018 Dec 18. Epub 2018 Dec 18.

National Institute for Occupational Safety and Health (NIOSH) Research Branch, Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania.

Background: Biliary tract cancers are rare, aggressive neoplasms. Most patients present with advanced/unresectable or metastatic disease at diagnosis, and no second-line regimen has demonstrated clinical benefit. This was a phase 2 study evaluating the efficacy and safety of regorafenib in patients who had advanced/unresectable or metastatic disease after receiving standard therapy. Read More

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http://dx.doi.org/10.1002/cncr.31872DOI Listing
December 2018
1 Read

Single-stranded DNA binding protein 2 expression is associated with patient survival in hepatocellular carcinoma.

BMC Cancer 2018 Dec 12;18(1):1244. Epub 2018 Dec 12.

Departments of Surgery, College of Medicine, Hanyang University222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.

Background: SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic malignancies, prostate cancer, esophageal squamous cell carcinoma, ovarian cancer, and gallbladder cancer. However, an oncogenic role of SSBP2 has been suggested in glioblastoma patients. Read More

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http://dx.doi.org/10.1186/s12885-018-5158-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291933PMC
December 2018
1 Read

Gallbladder Metastasis From Conjunctival Melanoma.

Clin Nucl Med 2019 Feb;44(2):e107-e109

From the Department of Nuclear Medicine, Institut Curie, PSL Research University, Paris, France.

Malignant conjunctival melanoma is a rare tumor. A 46-year-old woman with a history of locally recurrent left conjunctival melanoma was followed by F-FDG PET/CT. Four years after the local recurrence treated by orbital exenteration, the follow-up PET/CT scan showed an incidental intense FDG uptake mass infiltrating the gallbladder associated with a low uptake of an infracentimetric pulmonary nodule. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9732
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http://dx.doi.org/10.1097/RLU.0000000000002413DOI Listing
February 2019
8 Reads

First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors.

Invest New Drugs 2018 Dec 4. Epub 2018 Dec 4.

Department of Medical Oncology, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Background This first-in-human phase 1 study assessed the safety of TAS-114, a novel deoxyuridine triphosphatase inhibitor, combined with S-1 to determine its maximum tolerated dose (MTD) and recommended dose (RD). Methods In this dose-escalation study with a 3 + 3 design, TAS-114 and S-1 were concurrently administered orally under fasting conditions at 5-240 mg/m and 30-36 mg/m, respectively, in patients with advanced solid tumors. Safety, efficacy, and pharmacokinetics (PK) were evaluated. Read More

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http://dx.doi.org/10.1007/s10637-018-0697-3DOI Listing
December 2018
2 Reads

MiR-1-5p is down-regulated in gallbladder carcinoma and suppresses cell proliferation, migration and invasion by targeting Notch2.

Pathol Res Pract 2019 Jan 22;215(1):200-208. Epub 2018 Oct 22.

Emergency Trauma Surgery, BinZhou Medical University Hospital, Binzhou, Shandong, 256600, China. Electronic address:

Background: Numerous studies have demonstrated that aberrant microRNAs (miRNAs) are involved in tumorigenesis and tumor progression. Nevertheless, the precise role of miR-1-5p in gallbladder carcinoma cell growth and metastasis remains not fully revealed.

Material And Methods: The levels of miR-1-5p were detected in gallbladder carcinoma tissues and cell lines using qRT-PCR method. Read More

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http://dx.doi.org/10.1016/j.prp.2018.10.013DOI Listing
January 2019
10 Reads

Radiofrequency ablation of liver cancers adjacent to the gallbladder without gallbladder isolation under contrast-enhanced ultrasound monitoring: a preliminary study.

Int J Hyperthermia 2018 Nov 29:1-6. Epub 2018 Nov 29.

a Department of Medical Ultrasonics, Guangdong Key Laboratory of Liver Disease Research , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Purpose: The purpose of this study was to investigate the feasibility, safety and efficacy of intra-procedural contrast-enhanced ultrasound (CEUS) monitoring of the radiofrequency ablation (RFA) of liver cancers adjacent to gallbladder (GB) without GB isolation.

Materials And Methods: From May 2016 to July 2017, patients with liver cancers adjacent to GB (≤10 mm) who intended to undergo ultrasound-guided RFA without GB isolation in our hospital were prospectively enrolled. During the RFA procedures, CEUS was employed to evaluate the therapeutic response and the perfusion of the intact GB wall. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1539776DOI Listing
November 2018
8 Reads

Importance of routine histopathological examination of a gallbladder surgical specimen: Unexpected gallbladder cancer.

J Cancer Res Ther 2018 Oct-Dec;14(6):1325-1329

Department of General Surgery, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey.

Introduction: Cholecystectomy performed for benign diseases of the gallbladder is important for the diagnosis of gallbladder cancer. This is done by pathological examination of the removed specimens for patients with no detected or suspected complications before surgery. Although some centers undertake selective approaches for histopathological examination of gallbladder specimens, many centers perform this examination routinely. Read More

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http://dx.doi.org/10.4103/0973-1482.187301DOI Listing
February 2019
13 Reads

The impact of 2D cine MR imaging parameters on automated tumor and organ localization for MR-guided real-time adaptive radiotherapy.

Phys Med Biol 2018 Nov 22;63(23):235005. Epub 2018 Nov 22.

Joint Department of Physics at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.

2D cine MR imaging may be utilized to monitor rapidly moving tumors and organs-at-risk for real-time adaptive radiotherapy. This study systematically investigates the impact of geometric imaging parameters on the ability of 2D cine MR imaging to guide template-matching-driven autocontouring of lung tumors and abdominal organs. Abdominal 4D MR images were acquired of six healthy volunteers and thoracic 4D MR images were obtained of eight lung cancer patients. Read More

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http://dx.doi.org/10.1088/1361-6560/aae74dDOI Listing
November 2018
10 Reads

Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer.

Cancer Manag Res 2018 30;10:5101-5112. Epub 2018 Oct 30.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China,

Background: PIM1, a serine/threonine kinase, plays an essential role in tumorigenesis of multiple types of tumors. However, the expression pattern and functions of PIM1 in gallbladder cancer (GBC) remain largely unknown.

Materials And Methods: Immunohistochemistry, quantitative real-time PCR, and western blot analysis were performed to measure the expression of PIM1. Read More

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http://dx.doi.org/10.2147/CMAR.S184381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215917PMC
October 2018
9 Reads

Elective cholecystectomy as a rare presentation of metastatic breast cancer.

J Surg Case Rep 2018 Nov 13;2018(11):rjy301. Epub 2018 Nov 13.

Surgical Department, Centro Hospitalar Entre Douro e Vouga, E.P.E., Santa Maria da Feira, Portugal.

Cholecystectomy leads, occasionally, to the diagnosis of subclinical primary carcinomas and rarely metastatic tumors. The authors report the diagnosis of gallbladder metastasis after an elective cholecystectomy for symptomatic cholelithiasis. Histological examination disclosed a metastasis from a lobular breast carcinoma. Read More

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http://dx.doi.org/10.1093/jscr/rjy301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234511PMC
November 2018
13 Reads

[Radiologic diagnosis of the gallbladder and bile ducts - part 2 : Acute and chronic cholecystitis, primary sclerosing cholangitis (PSC), benign and malignant masses of the biliary system].

Radiologe 2018 Dec;58(12):1099-1114

Kinderradiologie im Dr. von Haunerschen Kinderspital der Radiologischen Klinik und Poliklinik, Ludwig-Maximilian-Universität München, München, Deutschland.

Upper abdominal pain, icterus and cholestasis are the symptoms leading to evaluation of the biliary tract. Together with its complications biliary stone disease is the main reason for inflammation of the biliary system. A distinction is made between acute and chronic variants. Read More

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http://dx.doi.org/10.1007/s00117-018-0463-8DOI Listing
December 2018
2 Reads

Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations.

Cancer 2019 Feb 14;125(4):575-585. Epub 2018 Nov 14.

Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Although rare in the United States, gallbladder cancer (GBCA) is a common cause of cancer death in some parts of the world. To investigate regional differences in pathogenesis and outcomes for GBCA, tumor mutations were analyzed from a sampling of specimens.

Methods: Primary tumors from patients with GBCA who were treated in Chile, Japan, and the United States between 1999 and 2016 underwent targeted sequencing of known cancer-associated genes. Read More

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http://dx.doi.org/10.1002/cncr.31850DOI Listing
February 2019
5 Reads
4.890 Impact Factor

Dedifferentiated liposarcoma of the gallbladder: first reported case.

World J Surg Oncol 2018 Nov 12;16(1):221. Epub 2018 Nov 12.

Department of Surgery, Federal University of Pernambuco, Recife, PE, Brazil.

Background: Liposarcoma of the gallbladder is an extremely rare sarcoma, with only five cases reported in the literature according to our knowledge.

Case Presentation: A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice. Abdominal ultrasonography and computed tomography (CT) evidenced an extensive gallbladder lobular formation adhered to the inferior border of the right hepatic lobe and cholelithiasis. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1520-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233360PMC
November 2018
11 Reads

Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 9;1865(2):308-321. Epub 2018 Nov 9.

Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Austria; Center for Biomarker Research in Medicine, Graz, Austria; Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Germany. Electronic address:

Biliary tract cancer (BTC) represents a malignant tumor of the biliary tract including cholangiocarcinoma (CCA) and the carcinoma of the gallbladder (GBC) with a 5-year survival rate between 5 and 18% due to late diagnosis and rapid disease progression. Chronic inflammation is one of the main risk factors for CCA and GBC in particular. IL-6, as a mediator of inflammation, can act through a membrane-bound receptor alpha-chain (mIL-6R, "IL-6 classic signaling") or via soluble forms (sIL-6R, "IL-6 trans-signaling"). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183045
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http://dx.doi.org/10.1016/j.bbadis.2018.11.006DOI Listing
February 2019
9 Reads

Five year experience of gallbladder polyp surveillance and cost effective analysis against new European consensus guidelines.

HPB (Oxford) 2018 Nov 8. Epub 2018 Nov 8.

Hepatopancreatobiliary Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.

Background: Gallbladder polyp (GBP) surveillance seeks to identify early neoplasms, but practice varies amongst surgical units. Recent European consensus guidelines have recommended an evidence-based GBP surveillance strategy. In a tertiary centre Hepato-Pancreato-Biliary unit we examine GBP surveillance, malignant yield, and assess cost-effectiveness of the new European consensus guidelines. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.10.008DOI Listing
November 2018
1 Read

Biodistribution, tumor detection and radiation dosimetry of F-18 5-Fluoro-2'-Deoxycytidine (F-FdCyd) with Tetrahydrouridine in solid tumors.

J Nucl Med 2018 Nov 2. Epub 2018 Nov 2.

Molecular Imaging Program, National Cancer Institute, National Institutes of Health, United States.

In pre-clinical studies, 5-fluoro-2'-deoxycytidine (FdCyd), an inhibitor of DNA methyltransferase and DNA hypermethylation, has shown treatment efficacy against multiple malignancies by suppressing epigenetic hypermethylation in tumor cells. Several clinical trials are undergoing using FdCyd and while some patients may respond to this drug, in the majority of patients it is ineffective. Thus, by establishing a non-invasive imaging modality to evaluate the distribution of the drug may provide insight into the variable responses. Read More

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http://dx.doi.org/10.2967/jnumed.118.216994DOI Listing
November 2018
17 Reads

An unusual presentation of gall bladder papillomatosis in association with metachromatic leukodystrophy.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Department of Paediatric Surgery, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.

A 5-year-old boy with metachromatic leukodystrophy, debilitated by spastic quadriparesis presented to us with massive ascites and respiratory distress. A subtotal cholecystectomy was performed on him from another centre for a gall bladder mass a year before he came to us. Imaging revealed a polypoidal frond-like mass arising from the gall bladder fossa which was supplied by a hypertrophied branch of the right hepatic artery. Read More

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http://dx.doi.org/10.1136/bcr-2017-224162DOI Listing
November 2018
2 Reads

Enhanced SLP-2 promotes invasion and metastasis by regulating Wnt/β-catenin signal pathway in colorectal cancer and predicts poor prognosis.

Pathol Res Pract 2019 Jan 24;215(1):57-67. Epub 2018 Oct 24.

Third Department of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, PR China.

Stomatin-like protein-2 (SLP-2) gene belongs to the stomatin supergene family, and previous studies have revealed up-regulated SLP-2 expression in gallbladder cancer, lung cancer, and esophageal cancer, while the role of SLP-2 in colorectal cancer (CRC) remains unclear and needs further investigation. Therefore, the expression levels of SLP-2 in CRC tissue and cell lines were tested in this study. Besides, we further explored the role of SLP-2 in CRC invasion and metastasis at molecular level via gene intervention technique. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183100
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http://dx.doi.org/10.1016/j.prp.2018.10.018DOI Listing
January 2019
6 Reads

Outcomes of surgery for 2010 WHO classification-based intraductal papillary neoplasm of the bile duct: Case-control study of a single Japanese institution's experience with special attention to mucin expression patterns.

Eur J Surg Oncol 2018 Oct 24. Epub 2018 Oct 24.

Department of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama City, Kanagawa, 236-0004, Japan. Electronic address:

Introduction: The World Health Organization (WHO) proposed an integrated classification for intraductal papillary neoplasm of the bile duct (IPNB) in 2010. However, IPNB reportedly shows considerable geographic variation. This Japanese single-institution study examined outcomes of surgery for IPNB and the prognostic impact of immunohistochemical mucin expression patterns. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.10.532DOI Listing
October 2018
2 Reads

Torsion Ovary, an Unusual Presentation of Carcinoma Appendix Detected in Whole-Body F-18 2-Fluoro 2-deoxy Glucose Positron Emission Tomography/Computed Tomography Scan.

Indian J Nucl Med 2018 Oct-Dec;33(4):331-333

Department of Nuclear Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Torsion ovary is one of the common emergencies in gynecology requiring surgery. Torsion ovary is generally caused by cystic lesions of ovary and benign tumors. Malignant tumors rarely present as torsion ovary. Read More

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http://www.ijnm.in/text.asp?2018/33/4/331/242954
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http://dx.doi.org/10.4103/ijnm.IJNM_97_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194758PMC
November 2018
11 Reads

Metabolic status and lifestyle factors associated with gallbladder polyps: a covariance structure analysis.

BMC Gastroenterol 2018 Nov 1;18(1):159. Epub 2018 Nov 1.

Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Background: Gallbladder Polyps (GBP) are highly prevalent in China; however, the etiology of GBP has not been clearly defined. This study explored the associations between lifestyle factors and GBP and whether it mediated by metabolic factors or not.

Methods: A total of 487 newly diagnosed GBP cases and 502 healthy controls were involved in this study. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0882-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211420PMC
November 2018
12 Reads

The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells.

J Cell Biochem 2018 Nov 1. Epub 2018 Nov 1.

Department of Clinical Research Laboratory, Clinical Research Laboratory, NingBo Second Hospital, NingBo, China.

Long noncoding RNAs (lncRNAs) have important functions in tumor development and progression, including colorectal cancer (CRC), but their roles are not completely understood. In this study, the roles of the lncRNA transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1 (TPTE2P1), previously implicated in gallbladder cancer cell migration and invasion, were evaluated in CRC. In particular, quantitative polymerase chain reaction was used to quantify TPTE2P1 levels in tumor tissues and cell lines. Read More

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http://doi.wiley.com/10.1002/jcb.27801
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http://dx.doi.org/10.1002/jcb.27801DOI Listing
November 2018
14 Reads

Synchronous cancers of gallbladder carcinoma and combined hepatocellular cholangiocarcinoma: an unusual case and literature review.

BMC Cancer 2018 Oct 29;18(1):1046. Epub 2018 Oct 29.

Hepatic Surgery Center, Institute of Hepato-Pancreato-Bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Background: Synchronous primary cancers in gallbladder and liver are rarely reported. Here we report an unusual case of synchronous cancers of gallbladder carcinoma and combined hepatocellular cholangiocarcinoma.

Case Presentation: Several lesions in the gallbladder and in adjacent parenchyma of liver were discovered in a 65-years-old woman by imaging examination. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4969-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205787PMC
October 2018
13 Reads
3.360 Impact Factor

Challenges and Technical Innovations for an Effective Laparoscopic Lymphadenectomy in Liver Malignancies.

J Laparoendosc Adv Surg Tech A 2019 Jan 27;29(1):72-75. Epub 2018 Oct 27.

Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milano, Italy.

Background: Intrahepatic cholangiocarcinoma (ICC) and gallbladder cancer (GC) are relatively uncommon indications for minimal invasiveness, mainly due to the technical complexity required for a laparoscopic loco-regional lymphadenectomy. The aim of this presentation is to provide a step-by-step overview for the technical approach to laparoscopic lymphadenectomy of the hepatic pedicle and parenchymal transection.

Materials And Methods: Two cases of an ICC and a GC are shown. Read More

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https://www.liebertpub.com/doi/10.1089/lap.2018.0568
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http://dx.doi.org/10.1089/lap.2018.0568DOI Listing
January 2019
8 Reads