11,939 results match your criteria Gallbladder Tumors


Detection of NRG1 gene fusions in solid tumors.

Clin Cancer Res 2019 Apr 15. Epub 2019 Apr 15.

Medical Oncology, Georgetown University

Background: NRG1 gene fusions are rare but potentially actionable oncogenic drivers present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking. Here, we assessed the incidence of NRG1 fusions across multiple tumor types and described fusion partners. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0160DOI Listing

Lymphatic spread of T2 gallbladder carcinoma: Regional lymphadenectomy is required independent of tumor location.

Eur J Surg Oncol 2019 Mar 30. Epub 2019 Mar 30.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan.

Background: This study aimed to investigate the incidence and distribution of regional lymph node metastasis according to tumor location, and to clarify whether tumor location could determine the extent of regional lymphadenectomy in patients with pathological T2 (pT2) gallbladder carcinoma.

Methods: In total, 81 patients with pT2 gallbladder carcinoma (25 with pT2a tumors and 56 with pT2b tumors) who underwent radical resection were enrolled. Tumor location was determined histologically in each gallbladder specimen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983193038
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http://dx.doi.org/10.1016/j.ejso.2019.03.038DOI Listing
March 2019
3 Reads

Porphyria cutanea tarda increases risk of hepatocellular carcinoma and premature death: a nationwide cohort study.

Orphanet J Rare Dis 2019 Apr 3;14(1):77. Epub 2019 Apr 3.

Norwegian Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway.

Background: Porphyria cutanea tarda (PCT) is a skin disorder originating from a deficit of the liver enzyme uroporphyrinogen decarboxylase. PCT may be a risk factor for hepatocellular carcinoma (HCC) and other cancers, but the evidence is unclear. We aimed to investigate cancer and premature mortality risk in persons with PCT. Read More

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http://dx.doi.org/10.1186/s13023-019-1051-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448269PMC
April 2019
2 Reads

A Mucinous Cystic Neoplasm Originating from the Gallbladder: A Case Report and Literature Review.

Perm J 2019 ;23

Department of General Surgery, Sinai Hospital, Baltimore, MD.

Introduction: Mucinous cystic neoplasms of the gallbladder are extremely rare, benign, unilocular or multilocular cystic tumors that contain septations. Mucinous cystadenoma, a subtype of mucinous cystic neoplasm, is defined as epithelial cystic proliferations composed of cells that contain intracytoplasmic mucin.

Case Presentation: A 70-year-old African American woman was admitted to the hospital because of progressive lower back pain and inability to walk. Read More

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http://dx.doi.org/10.7812/TPP/18-077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443366PMC
January 2019
1 Read

[Helical tomotherapy using simultaneously integrated boost and simultaneous integrated protection technique for unresectable biliary tract cancer].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):293-298

The Comprehensive Cancer Centre of Drum Tower Hospital, the Affiliated Drum Tower Clinical College of Nanjing Medical University, Nanjing 210008, China.

To evaluate the safety and efficacy of helical tomotherapy using simultaneously integrated boost and simultaneous integrated protection technique in the treatment of unresectable biliary tract cancers. The data of 23 patients with unresectable biliary tract cancer who received tomotherapy-based hypofractionated radiotherapy at Comprehensive Cancer Centre of Drum Tower Hospital,the Affiliated Drum Tower Clinical College of Nanjing Medical University between February 2015 and October 2017 were analyzed. There were 10 males and 13 females, aged from 40 to 85 years(median:58 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.010DOI Listing
April 2019
2 Reads

[Laparoscopic treatment for incidental gallbladder cancer: a retrospective 10 years study from a single institution].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):277-281

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

To explore the feasibility of laparoscopic treatment for incidental gallbladder cancer(IGBCA) and analyze the factors influencing prognosis. A retrospective study of 71 patients with IGBCA received laparoscopic treatment at Department of General Surgery, Peking University Third Hospital from January 2007 to December 2016 was conducted,the clinicopathological data and prognosis were analyzed. There were 18 males and 53 females,aged 23 to 81 years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.007DOI Listing
April 2019
1 Read

[Clinical study of S-1 single agent adjuvant chemotherapy in the radical resection of extrahepatic biliary carcinoma].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):271-276

Department of Hepatobiliary-Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

To explore the clinical efficacy of S-1 single agent adjuvant chemotherapy for the patients undergoing radical resection of extrahepatic biliary carcinoma. The clinical data of 108 patients with extrahepatic biliary carcinoma receiving radical resection who were admitted from January 2014 to June 2017 were retrospectively analyzed. There were 62 males(57. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.006DOI Listing
April 2019
1 Read

[Diagnosis and treatment for unexpected gallbladder carcinoma(a retrospective study of 45 cases)].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):265-270

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

To investigate the rationale for appropriate diagnostic methods and treatment protocols for unexpected gallbladder carcinoma(UGC). The clinical and pathological data of 45 patients with UGC admitted at Department of General Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine,from January 2008 to December 2017 were retrospectively collected and analyzed.There were 11 males(28. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.005DOI Listing
April 2019
1 Read

[Pilot study of the relationship between clinical classification of gallbladder cancer and prognosis: a retrospective multicenter clinical study].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):258-264

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To propose a novel clinical classification system of gallbladder cancer, and to investigate the differences of clinicopathological characteristics and prognosis based on patients who underwent radical resection with different types of gallbladder cancer. The clinical data of 1 059 patients with gallbladder cancer underwent radical resection in 12 institutions in China from January 2013 to December 2017 were retrospectively collected and analyzed.There were 389 males and 670 females, aged (62. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.004DOI Listing
April 2019
1 Read

Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.

Pathol Oncol Res 2019 Mar 29. Epub 2019 Mar 29.

Dental Research Center, Dentistry Research Institute, Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

All different types of metabolism of tumors are dependent on the flow of water molecules through the biological membrane, where fluid transfer interceded by aquaporins (AQPs) are the basis means for water entrance into the cells or outside them. Aquaporins play other roles including cellular migration, cellular expansion and cellular adhesion facilitation. Therefore, regulators of AQPs may be useful anticancer agents. Read More

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http://dx.doi.org/10.1007/s12253-019-00646-9DOI Listing

[Metastases in trocar sites secondary to gallbladder adenocarcinoma].

Pan Afr Med J 2018;31:52. Epub 2018 Sep 24.

Service de Chirurgie Viscérale et Digestive de l'Hôpital Militaire d'Instruction Mohamed V de Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2018.31.52.14630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431412PMC
April 2019
1 Read

Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report.

World J Surg Oncol 2019 Mar 22;17(1):55. Epub 2019 Mar 22.

Faculty of Medicine in Pilsen, Charles University, 301 00, Pilsen, Czech Republic.

Background: Mixed neuroendocrine-non-neuroendocrine tumors (MINEN) of the gallbladder are extremely rare; indeed, the English expert literature reports a mere handful of case reports and case series on this topic. According to the WHO classification of 2010, MINEN are considered to be tumors consisting of two major components, neuroendocrine and non-neuroendocrine, each of which hosts at least 30% of the total cellular population. To date, the etiology and pathogenesis of MINEN have not been precisely determined and the non-specific symptoms generally result in late diagnosis (mainly in the terminal stages of the condition) and contribute to the generally poor prognosis. Read More

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http://dx.doi.org/10.1186/s12957-019-1598-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429764PMC
March 2019
1 Read

Prognostic Impact of Lymph Node Excision in T1 and T2 Gallbladder Cancer: a Population-Based and Propensity Score-Matched SEER Analysis.

J Gastrointest Surg 2019 Mar 18. Epub 2019 Mar 18.

Department of General, Visceral, Endocrine and Transplant Surgery, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007, St. Gallen, Switzerland.

Purpose: The aim of this study was to assess the effect of lymphadenectomy on survival in T1/T2 gallbladder cancer (GBC).

Methods: In this retrospective cohort study, patients undergoing surgery for T1/T2 GBC from 2004 to 2014 were identified in the Surveillance, Epidemiology, and End Results database. The effect of lymph node excision (LNE) on survival was assessed using Cox regression and propensity score methods. Read More

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http://dx.doi.org/10.1007/s11605-019-04175-3DOI Listing
March 2019
2 Reads

Gallbladder polyps - a follow-up study after 11 years.

BMC Gastroenterol 2019 Mar 18;19(1):42. Epub 2019 Mar 18.

Centre for Internal Medicine, Department of Internal Medicine I, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Background: The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.

Methods: Four hundred and thirteen subjects (190 women, 223 men; aged 29-75 years) were studied first in 2002 and again eleven years later in 2013. All subjects were interviewed using a standardised questionnaire, anthropometric data were recorded, and an abdominal ultrasound scan was carried out. Read More

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http://dx.doi.org/10.1186/s12876-019-0959-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423886PMC
March 2019
1 Read

Massive hemoperitoneum and upper gastrointestinal hemorrhage following liver rupture secondary to gallbladder perforation: A case report and literature review.

Medicine (Baltimore) 2019 Mar;98(11):e14729

Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chendu, Sichuan.

Rationale: Available literature states that the common reasons for non-traumatic spontaneous liver rupture are hepatocellular carcinoma, macronodular cirrhosis, hemangioma, and other tumors; gallbladder perforation is not cited as a cause.

Patient Concerns: The patient presented with sudden-onset right upper quadrant pain with tarry stool for 3 days after eating with dysphoria and increasing thirst; gradually, hemorrhagic shock developed. He had no history of trauma, no background of chronic hepatitis, and no cirrhosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426586PMC
March 2019
1 Read

Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.

Oncol Lett 2019 Apr 14;17(4):3890-3898. Epub 2019 Feb 14.

Department of Gastroenterology, University Hospital Heidelberg, D-69120 Heidelberg, Germany.

Recently, a tumor-autonomous cytochrome P450 (CYP)-3A5-mediated resistance to cancer therapy has been demonstrated in pancreatic ductal adenocarcinoma. Expression of CYP3A5, which is involved in the degradation of irinotecan, has also been reported in colorectal cancer (CRC). The aim of the present study was to analyze CYP3A5 expression in the normal colon, colon adenoma, CRC and normal tissues, as well as to examine whether CYP3A5 expression in CRC has an impact on tumor response to irinotecan treatment. Read More

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http://dx.doi.org/10.3892/ol.2019.10043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403523PMC
April 2019
2 Reads

The safety of newly developed automatic temperature-controlled endobiliary radiofrequency ablation system for malignant biliary strictures: A prospective multicenter study.

J Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University School of Medicine, Korea.

Background And Aims: Catheter-based endobiliary radiofrequency ablation (RFA) is an endoscopic local treatment for patients with malignant biliary stricture (MBS). However, excessive heating of the bile duct by the current RFA system can induce serious complications. Recently, a new RFA system with automatic temperature control was developed. Read More

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http://doi.wiley.com/10.1111/jgh.14657
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http://dx.doi.org/10.1111/jgh.14657DOI Listing
March 2019
10 Reads

Minimally Invasive Surgery for Gallbladder Cancer.

Surg Oncol Clin N Am 2019 04 2;28(2):243-253. Epub 2019 Feb 2.

Department of Digestive Surgery, Faculty of Medicine, Catholic University of Chile, Avenida Libertador Bernardo O'Higgins 390, Santiago 8331150, Chile; Department of Digestive Surgery, Faculty Medicine, Catholic University of Chile, Sotero del Rio Hospital, Concha y Toro Avenue 3459, Puente Alto, Santiago 8207257, Chile. Electronic address:

There is consensus that oncologic extended resection should be performed for resectable incidental and nonincidental gallbladder cancer. The safety and feasibility of a minimally invasive approach to oncologic extended resection of gallbladder cancer has been demonstrated and is performed in centers of expertise worldwide. In this article, a systematic approach to the indications and techniques for a minimally invasive approach to extended resection for gallbladder cancer is detailed. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.001DOI Listing
April 2019
1 Read

Uncommon site of metastasis from renal cell carcinoma: Case report.

Int J Surg Case Rep 2019 13;56:45-48. Epub 2019 Feb 13.

Department of Oncology, Real e Benemérita Associação Portuguesa de Beneficência, Brazil.

Background: Renal cell carcinomas (CCR) account for 90% of renal tumors. Presence of latent distant metastasis is characteristic of RCC and may manifest more than a decade after nephrectomy. Gallbladder (GB) is a rare site of metastasis, with few reports in the literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193007
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http://dx.doi.org/10.1016/j.ijscr.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406048PMC
February 2019
8 Reads

[Gallbladder epidermoid carcinoma].

Rev Med Chil 2018 Dec;146(12):1438-1443

Departamento de Cirugía Oncológica Gastrointestinal, Instituto Nacional de Cancerología, México.

Background: Gallbladder epidermoid carcinoma is rare and more common in women over 55 years of age.

Aim: To report the features of 15 patients with gallbladder epidermoid carcinoma.

Material And Methods: Review of medical records of patients with gallbladder cancer in an oncology service. Read More

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http://dx.doi.org/10.4067/s0034-98872018001201438DOI Listing
December 2018
4 Reads

Gallbladder Cancer: Diagnosis, Surgical Management, and Adjuvant Therapies.

Surg Clin North Am 2019 Apr;99(2):337-355

Division of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Gallbladder cancer (GBC) is an often lethal disease, but surgical resection is potentially curative. Symptoms may be misdiagnosed as biliary colic; over half of new diagnoses are made after laparoscopic cholecystectomy for presumed benign disease. Gallbladder polyps >1 cm should prompt additional imaging and cholecystectomy. Read More

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http://dx.doi.org/10.1016/j.suc.2018.12.008DOI Listing
April 2019
1 Read

More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.

Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7.

Department of Nuclear Medicine and PET/CT, Evangelismos General Hospital, Ypsilantou 45-47, PC 106 76, Athens, Greece.

Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Read More

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http://dx.doi.org/10.1967/s002449910952DOI Listing
March 2019
9 Reads

Prognostic Role of Claudin-1 Immunohistochemistry in Malignant Solid Tumors: A Meta-Analysis.

J Pathol Transl Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Urology, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea.

Background: Although the correlation between low claudin-1 expression and worse prognosis has been reported, details on the prognostic implications of claudin-1 expression in various malignant tumors remain unclear. The present study aimed to elucidate the prognostic roles of claudin-1 immunohistochemistry (IHC) in various malignant tumors through a meta-analysis.

Materials And Methods: The study included 2,792 patients from 22 eligible studies for assessment of the correlation between claudin-1 expression and survival rate in various malignant tumors. Read More

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http://dx.doi.org/10.4132/jptm.2019.02.03DOI Listing
March 2019
5 Reads

Asymptomatic malignant melanoma of the gallbladder with multiple brain metastases diagnosed with endoscopic ultrasound-guided fine-needle aspiration cytology.

Clin J Gastroenterol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, Fujimoto General Hospital, 17-1, Hayasuzu, Miyakonojo, Miyazaki, 885-0055, Japan.

Malignant melanoma of the gallbladder (MMG) is extremely rare and its early stage diagnosis is difficult. Most reports of MMG describe metastatic tumors. We herein report a rare case of presumed primary MMG diagnosed by endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) cytology without surgical resection. Read More

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http://dx.doi.org/10.1007/s12328-019-00957-zDOI Listing
March 2019
2 Reads

Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):967-999. Epub 2019 Mar 1.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Objective: The abnormal expression of the key enzymes in glycolytic pathways, including glucose transporter-1, glucose transporter-3, hexokinase-II, lactate dehydrogenase 5, pyruvate kinase M2, glucose-6-phosphate dehydrogenase, transketolase-like protein 1 and pyruvate dehydrogenase kinase-1 was reported to be associated with poor prognosis of various cancers. However, the association remains controversial. The objective of this study was to investigate the prognostic significance of glycolysis-related proteins. Read More

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http://dx.doi.org/10.1007/s00432-019-02847-wDOI Listing
April 2019
2 Reads

Fine-needle aspiration cytology of gallbladder with an attempt of cytomorphological classification.

Cytojournal 2019 22;16. Epub 2019 Jan 22.

Department of Surgery, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Background: Image-guided fine-needle aspiration has emerged as an effective diagnostic tool for precise diagnosis of deep-seated lesions. Although occasional studies have made an attempt to classify the gallbladder carcinoma on cytology, literature lacks the standardized cytological nomenclature system used for it. The present study was conducted to study the role of fine-needle aspiration cytology (FNAC) in diagnosis of gallbladder lesions with an attempt of cytomorphological classification. Read More

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http://dx.doi.org/10.4103/cytojournal.cytojournal_5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367906PMC
January 2019
1 Read

Synchronous gallbladder adenocarcinoma and gastric gastrointestinal stromal tumor: Case report and literature review.

Int J Surg Case Rep 2019 13;56:25-28. Epub 2019 Feb 13.

Division of Pathology, Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address:

Introduction: Synchronous occurrence of different types of neoplasms is not very frequent, representing around 6% of all cases of cancer. Usually there is a lack of information on how to treat these patients, especially when both types of cancers are also uncommon. No cases of synchronous gallbladder adenocarcinoma and gastric gastrointestinal stromal tumor have been published before. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393670PMC
February 2019
3 Reads

Prognostic significance of neutrophil-lymphocyte ratio and carbohydrate antigen 19-9 in patients with gallbladder carcinoma.

Medicine (Baltimore) 2019 Feb;98(8):e14550

Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Si chuan Province, China.

The neutrophil-lymphocyte ratio (NLR) is an immune response-related indicator and it is associated with poor prognosis of various cancers. The carbohydrate antigen19-9 (CA19-9) is a tumor-associated antigen and it has prognostic relevance in gallbladder carcinoma (GBC). We aimed to analyze whether preoperative NLR and serum CA19-9 were associated with outcomes of GBC patients after surgery with curative intent. Read More

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http://dx.doi.org/10.1097/MD.0000000000014550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407978PMC
February 2019
1 Read

Intracholecystic Papillary Neoplasms are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.

Am J Surg Pathol 2019 Feb 21. Epub 2019 Feb 21.

Departments of Diagnostic Pathology.

Although intracholecystic papillary neoplasms (ICPNs) have been increasingly recognized, their features remain unclear because of the lack of standardized definition. This study aimed to elucidate clinicopathologic and genetic features of ICPNs using stringent diagnostic criteria. On the basis of the recently proposed criteria, gallbladder neoplasms showing delicate papillary growth were diagnosed as ICPNs, while polypoid papillary adenocarcinomas arranged in a complex architecture were categorized as papillary gallbladder cancers (GBCs). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001237DOI Listing
February 2019
1 Read

Biliary Neuroendocrine Neoplasms: Clinical Profiles, Management, and Analysis of Prognostic Factors.

Front Oncol 2019 5;9:38. Epub 2019 Feb 5.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Biliary neuroendocrine neoplasms (NENs) represent <1% of all NENs. The aim of this retrospective study is to present the clinical characteristics, management and prognosis profiles of 28 biliary NEN patients from a large tertiary center, and identify factors related to prognosis. Nine tumors originated from the gallbladder, two from the extrahepatic bile duct and 17 from the ampulla of Vater. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00038/
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http://dx.doi.org/10.3389/fonc.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370735PMC
February 2019
2 Reads

Robotic hepatectomy for benign and malignant liver tumors.

J Robot Surg 2019 Feb 23. Epub 2019 Feb 23.

Digestive Disease Institute, Florida Hospital Tampa, 3000 Medical Park Dr, Suite #500, Tampa, FL, 33613, USA.

Minimally invasive hepatectomy for benign and malignant liver lesions has gained popularity in the past decade due to improved perioperative outcomes when compared to conventional 'open' technique. We aim to investigate our initial experience of robotic hepatectomy undertaken in our hepatobiliary program. All patients undergoing robotic hepatectomy between 2013 and 2018 were prospectively followed. Read More

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http://dx.doi.org/10.1007/s11701-019-00935-0DOI Listing
February 2019
1 Read

[Differential diagnosis of gallbladder abnormalities : Ultrasound, computed tomography, and magnetic resonance imaging].

Radiologe 2019 Apr;59(4):328-337

Radiologie, KFJ Spital, Wien, Österreich.

Clinical Issue: Due to the high prevalence of clinically suspected cholecystitis or cholecystolithiasis the gallbladder is one of the organs examined the most by imaging.

Standard Radiological Methods: In most clinical settings ultrasound is the primary imaging method because of its wide availability, speed and superior spatial resolution. In cases of ambiguous findings or potential complications computed tomography (CT) and magnetic resonance imaging (MRI) are used. Read More

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http://dx.doi.org/10.1007/s00117-019-0504-yDOI Listing

Multimodality management of incidentally detected gall bladder cancer: long term results from a tertiary care cancer centre.

J Gastrointest Oncol 2019 Feb;10(1):128-133

Department of Surgical Oncology, All India Institute of Medical sciences (AIIMS), New Delhi, India.

Background: Gall bladder cancer (GBC) is the most common biliary tract malignancy in India. GBC present either with incidental diagnosis after simple cholecystectomy (SC) or with a primary gall bladder mass. Incidentally detected gall bladder cancer (ICGB) has traditionally been thought to be a relatively early stage disease but there are controversies associated with various aspects of its management. Read More

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http://dx.doi.org/10.21037/jgo.2018.09.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351296PMC
February 2019

Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies.

World J Gastroenterol 2019 Feb;25(6):659-671

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra- and/or extrahepatic biliary ducts. While its features and disease course can be variable, most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378537PMC
February 2019
2 Reads

Hepatic hypertrophy and hemodynamics of portal venous flow after percutaneous transhepatic portal embolization.

BMC Surg 2019 Feb 18;19(1):23. Epub 2019 Feb 18.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita15-Nishi7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: Percutaneous transhepatic portal embolization (PTPE) is useful for safe major hepatectomy. This study investigated the correlation between hepatic hypertrophy and hemodynamics of portal venous flow by ultrasound sonography after PTPE.

Methods: We analyzed 58 patients with PTPE, excluding those who underwent recanalization (n = 10). Read More

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http://dx.doi.org/10.1186/s12893-019-0486-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379972PMC
February 2019
1 Read

Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.

J Gastrointest Surg 2019 Apr 12;23(4):818-824. Epub 2019 Feb 12.

Section of Hepatobiliary and Pancreatic Surgery, Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Background: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease.

Materials And Methods: We maintain a prospective high volume gastrointestinal malignancy PDX program. Read More

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http://dx.doi.org/10.1007/s11605-019-04109-zDOI Listing
April 2019
1 Read

Gallbladder Polyps: Real or Imagined?

Am Surg 2018 Oct;84(10):1670-1674

Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

The finding of gallbladder polyps on imaging studies prompts further workup. Imaging results are often discordant with final pathology. The goal of this study is to compare polypoid lesions of the gallbladder found on preoperative ultrasound (US) with final pathologic diagnosis after cholecystectomy to help guide clinical decision-making. Read More

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October 2018
12 Reads

"-Omas" presenting as "-itis": acute inflammatory presentations of common gastrointestinal neoplasms.

Emerg Radiol 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Oncologic emergencies have a high rate of morbidity and mortality. This review covers several scenarios of gastrointestinal malignancies presenting emergently as various acute abdominal pathologies. Radiologists should be familiar with the typical imaging findings, clinical presentations, and laboratory values which may suggest a background neoplasm, particularly when encountered in the context of an acute inflammatory state. Read More

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http://dx.doi.org/10.1007/s10140-019-01678-zDOI Listing
February 2019
2 Reads

Long non-coding RNA DILC promotes the progression of gallbladder carcinoma.

Gene 2019 Apr 1;694:102-110. Epub 2019 Feb 1.

Department of Biliary Tract Surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai 200438, China. Electronic address:

Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) contribute to tumorigenesis, progression and recurrence of various malignancies including Gallbladder carcinoma (GBC). Lnc-DILC is reported to be the tumor suppressor gene to play an important role in liver cancer stem cells (CSCs). However, the role of lnc-DILC in GBC remains to be elucidated. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.086DOI Listing
April 2019
1 Read

Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report.

Surg Case Rep 2019 Feb 4;5(1):17. Epub 2019 Feb 4.

Department of Surgery, Maizuru Medical Center, Kyoto, Japan.

Background: Metastases to the stomach or gallbladder from any malignancy is rarely noted, and simultaneous metastases to both organs are atypical. We present a unique case of simultaneous multifocal metastases of the stomach and gallbladder from renal cell carcinoma (RCC).

Case Presentation: The case involved a 60-year-old man, with a past history of RCC (clear cell type, G2, T1b N0 M0 Stage I) treated by a right nephrectomy. Read More

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http://dx.doi.org/10.1186/s40792-019-0569-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364323PMC
February 2019
2 Reads

Incidental versus non-incidental gallbladder cancer: index cholecystectomy before oncologic re-resection negatively impacts survival in T2b tumors.

HPB (Oxford) 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Conflicting data exists whether non-oncologic index cholecystectomy (IC) leading to discovery of incidental gallbladder cancer (IGBC) negatively impacts survival. This study aimed to determine whether a subgroup of patients derives a disadvantage from IC.

Methods: Patients with IGBC and non-IGBC treated at an academic USA and Chilean center during 1999-2016 were compared. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.12.006DOI Listing
January 2019
1 Read

Uncommon Intraluminal Tumors of the Gallbladder and Biliary Tract: Spectrum of Imaging Appearances.

Radiographics 2019 Mar-Apr;39(2):388-412. Epub 2019 Feb 1.

From the Departments of Radiology (A.C., C.L.V., P.N., N.A.H., V.Y., F.H.M.) and Pathology (A.J.B., G.Y.Y.), Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 800, Chicago, IL 60611; Department of Radiology, Emory University School of Medicine, Atlanta, Ga (P.K.M.); and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

Intraluminal pathologic conditions of the bile ducts and gallbladder are common, most frequently consisting of calculi and adenocarcinoma. In recent years, intraductal papillary neoplasm of the bile ducts (IPN-B), which is analogous to intraductal papillary mucinous neoplasm of the pancreas, has been recognized as a distinct pathologic entity and a precursor lesion to adenocarcinoma of the bile ducts. Intraductal tubulopapillary neoplasm (ITPN) of the bile duct was subsequently described as a distinct pathologic entity. Read More

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http://dx.doi.org/10.1148/rg.2019180164DOI Listing
February 2019
4 Reads

Role of digital single-operator cholangioscopy in the diagnosis and treatment of biliary disorders.

World J Gastrointest Endosc 2019 Jan;11(1):31-40

Department of Interventional Gastroenterology, Clinic of Gastroenterology, Acibadem City Clinic Tokuda Hopsital, Sofia 1407, Bulgaria.

Due to the need for improvement in the diagnosis and minimally invasive therapy of the bile duct disorders new technologies for cholangioscopy have been recently developed. Per-oral cholangioscopy has become an important diagnostic and therapeutic tool leading to avoidance of aggressive and unnecessary surgery in many clinical scenarios. This paper focuses on the newly developed SpyGlass DS technology, its advantages, and the technique of single-operator cholangioscopy (SOC), biliary indications and possible adverse events. Read More

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http://dx.doi.org/10.4253/wjge.v11.i1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354115PMC
January 2019
4 Reads

Positive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator.

Eur J Surg Oncol 2019 Jan 24. Epub 2019 Jan 24.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Prognostic factors following index-cholecystectomy in patients with incidental gallbladder cancer (IGBC) are poorly understood. The aim of this study was to assess the value of the initial cystic duct margin status as a prognosticator factor and to aid in clinical decision making to move forward with curative intent oncologic extended resection (OER).

Methods: This retrospective study included patients with IGBC who underwent subsequent OER with curative intent at 2 centers (USA and Chile) between 1999 and 2016. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.013DOI Listing
January 2019
2 Reads

[Treatment Outcomes of Gemcitabine and Cisplatin Combination Therapy for Unresectable and Recurrent Biliary Tract Cancer].

Gan To Kagaku Ryoho 2018 Dec;45(13):2414-2416

Dept. of Surgery, Kansai Rosai Hospital.

Gemcitabine and cisplatin combination therapy(GC therapy)is now considered a highly effective regimen for patients with unresectable and metastatic biliary tract cancer. We performed GC therapy for 18 patients between January 2014 and April 2018. The median age of the patients was 67. Read More

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December 2018
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[A Resected Case of Gallbladder Cancer Concomitant with Xanthogranulomatous Cholecystitis with Difficulty in Preoperative Diagnosis].

Gan To Kagaku Ryoho 2018 Dec;45(13):2411-2413

Dept. of Surgery, Toyonaka Municipal Hospital.

A 78-year-oldman was referredto our hospital for right abdominal pain. The patient was diagnosedwith xanthogranulomatous cholecystitis(XGC)at the gallbladder fundus and adenomyomatosis(ADM)at the gallbladder neck. Because malignancy was undeniable, laparotomy was performed. Read More

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December 2018
2 Reads

[A Case of Gallbladder Jejunal Anastomosis and Duodenal Jejunal Anastomosis to Maintain QOL for an Elderly Patient with Pancreatic Cancer].

Gan To Kagaku Ryoho 2018 Dec;45(13):1818-1820

Dept. of Surgery, Numazu City Hospital.

An 87-year-oldwoman was admittedto our hospital with abdominal pain andfever. Computedtomography showeda 25 mm tumor mass in the pancreatic headandshowedd ilatation of the pancreatic duct andcommon bile duct. She was diagnosed with obstructive cholangitis due to pancreatic head cancer. Read More

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December 2018
2 Reads

[A Case of Laparoscopic Cholecystectomy(TANKO)for Gallbladder Cancer with Torsion].

Gan To Kagaku Ryoho 2018 Dec;45(13):2211-2213

Dept. of Surgery, Saiseikai Shiga Hospital.

Gallbladder torsion is comparatively rare. Gallbladder cancer is found in 1.5% of cases of acute cholecystitis. Read More

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December 2018
9 Reads

[A Case of Advanced Gallbladder Cancer with Paraaortic Lymph Node Metastases Successfully Treated by Chemotherapy and Conversion Surgery].

Gan To Kagaku Ryoho 2018 Dec;45(13):2117-2119

Dept. of Surgery, Shizuoka City Shimizu Hospital.

The patient was a 76-year-old man who was admitted to our hospital with a diagnosis of ileus. A gallbladder tumor was found incidentally on CT, and it was diagnosed as gallbladder cancer. Enlargement of multiple lymph nodes, including the paraaortic lymph nodes, was observed, and PET-CT further showed FDG uptake in the lymph nodes. Read More

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December 2018
2 Reads