1,479 results match your criteria Gallbladder Carcinoma Imaging


Tuberculosis of the gallbladder-another one of its many faces.

Indian J Tuberc 2020 Apr 24;67(2):257-259. Epub 2019 Aug 24.

Department of Radiodiagnosis and Modern Imaging, SMS Medical College, Jaipur, Rajasthan, India.

Abdominal tuberculosis is not uncommon in developing countries which usually presents as involvement of ileo-caecal junction. Involvement of gall bladder by tuberculosis is rare and thus, imaging diagnosis is unlikely. The diagnosis is confirmed only on histopathology. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.08.011DOI Listing

Chronic gallbladder wall thickening: Is it always malignancy?

SA J Radiol 2020 18;24(1):1844. Epub 2020 May 18.

Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Gallbladder wall thickening, associated with features like perforation, fistula formation and invasion of adjacent organs, is often assumed to be malignant. Xanthogranulomatous cholecystitis (XGC) causes gallbladder wall thickening with similar aggressive features and closely mimics gallbladder carcinoma clinically, radiologically and surgically. Differentiating between these two is crucial for management as misdiagnosis of gallbladder cancer can lead to unnecessary radical surgery. Read More

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http://dx.doi.org/10.4102/sajr.v24i1.1844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276480PMC

Mixed adenoneuroendocrine carcinoma of the gallbladder, amphicrine type: Case report and review of literature.

Pathol Res Pract 2020 Jul 4;216(7):152997. Epub 2020 May 4.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

Amphicrine type mixed adenoneuroendocrine carcinoma (MANEC), also known as amphicrine carcinoma, is an exceedingly rare neoplasm comprising of tumor cells simultaneously demonstrating both neuroendocrine and exocrine differentiation. Majority of reported cases were found in tubular gastrointestinal tracts such as colon. Herein, we report the first case of amphicrine carcinoma in gallbladder in a 57-year-old female who presented with abdominal pain, vomiting, and gallbladder mass on imaging followed by radical cholecystectomy. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152997DOI Listing

Effects of Primary Sclerosing Cholangitis on Risks of Cancer and Death in People With Inflammatory Bowel Diseases, Based on Sex, Race, and Age.

Gastroenterology 2020 May 20. Epub 2020 May 20.

NIHR Birmingham Biomedical Research Centre, Centre for Liver and Gastroenterology Research, University of Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, UK; Toronto Centre for Liver Disease, University Health Network and Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Background & Aims: There are insufficient population-level data on effects of primary sclerosing cholangitis (PSC) in patients with inflammatory bowel disease (IBD).

Methods: We identified incident cases of IBD, with PSC (PSC-IBD) and without, from April 2006 through to April 2016 and collected data on outcomes through April 2019. We linked data from national healthcare registries maintained for all adults in England on hospital attendances, imaging and endoscopic evaluations, surgical procedures, cancer, and deaths. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.05.049DOI Listing

Oncologic safety of laparoscopic radical cholecystectomy in pT2 gallbladder cancer: A propensity score matching analysis compared to open approach.

Medicine (Baltimore) 2020 May;99(20):e20039

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine.

The role of laparoscopic radical cholecystectomy (LRC) in the surgical management of T2 gallbladder carcinoma (GBC) is still controversial.The medical records of patients with T2 GBC treated with radical cholecystectomy were retrospectively reviewed. In this study, we compare the short- and long-term oncologic outcomes, using propensity score matching analysis, of patients with T2 GBC who underwent LRC and open radical cholecystectomy (ORC). Read More

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http://dx.doi.org/10.1097/MD.0000000000020039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253605PMC

Gallbladder metastasis of renal cell carcinoma presenting as a hypervascular polypoid lesion: case report of two cases with immunohistochemical analysis.

Surg Case Rep 2020 Apr 28;6(1):86. Epub 2020 Apr 28.

Department of Surgery1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.

Background: Metastasis of renal cell carcinoma (RCC) to the gallbladder is rare, and its clinicopathological feature remains poorly understood. We here present two cases of gallbladder metastasis from RCC presenting as a hypervascular polypoid lesion.

Case Presentation: The first case was a 73-year-old man who had undergone right nephrectomy for clear cell RCC. Read More

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http://dx.doi.org/10.1186/s40792-020-00814-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188748PMC

Laparoscopic total biopsy for suspected gallbladder cancer: A case series.

Health Sci Rep 2020 Jun 20;3(2):e156. Epub 2020 Apr 20.

Department of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Ube Yamaguchi Japan.

Background And Aims: Imaging diagnosis of gallbladder cancer remains difficult to achieve preoperatively. We developed a novel approach based on laparoscopic whole-layer cholecystectomy (LWLC) and laparoscopic gallbladder bed dissection (LGBD) for total biopsy, for ultimately determining the optimal treatment strategy for suspected gallbladder cancer detected on preoperative imaging. Here, we describe a case series of patients who underwent this procedure at our institution. Read More

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http://dx.doi.org/10.1002/hsr2.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167592PMC

Value of F-FDG PET/CT in the detection of occult malignancy in patients with dermatomyositis.

Heliyon 2020 Apr 3;6(4):e03707. Epub 2020 Apr 3.

PET Center, Huashan Hospital of Fudan University, Shanghai, 200235, PR China.

Aim: Dermatomyositis (DM) is an inflammatory myopathy in adults that is strongly associated with malignancy. The aim of this study was to evaluate whether whole-body F-FDG PET/CT imaging can offer a standard option searching for underlying malignancy in DM patients.

Methods: Seventy-five patients diagnosed with DM were referred to our department for whole-body F-FDG PET/CT to determine whether the patients suffered from malignant tumor. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132068PMC

Axillary metastases after port site recurrences of gallbladder carcinoma: a case report.

World J Surg Oncol 2020 Apr 7;18(1):69. Epub 2020 Apr 7.

Department of Surgical Oncology, Medisch Spectrum Twente, Enschede, the Netherlands.

Background: Incidental gallbladder carcinoma is often discovered after elective laparoscopic cholecystectomy for cholecystitis or cholecystolithiasis. Port site recurrences may occur. Patients with port site metastases of gallbladder carcinoma have a poor prognosis. Read More

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http://dx.doi.org/10.1186/s12957-020-01822-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137273PMC

[Guideline for the diagnosis and treatment of gallbladder carcinoma (2019 edition)].

Authors:

Zhonghua Wai Ke Za Zhi 2020 Apr;58(4):243-251

In order to improve the overall therapeutic effect of gallbladder cancer in China, Branch of Biliary Surgery, Chinese Surgical Society and Chinese Committee of Biliary Surgeons have formulated the guideline for the diagnosis and treatment of gallbladder carcinoma (2019 edition) . The guideline provided an overview of the evidence on epidemiological risk factors, treatment and follow-up strategies for patients with gallbladder cancer.It also updated the new TNM stage and proposed the clinical classification of gallbladder cancer for the first time. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200106-00014DOI Listing

An Important Gallbladder Pathology Mimicking Gallbladder Carcinoma: Xanthogranulomatous Cholecystitis: A Single Tertiary Center Experience.

Surg Laparosc Endosc Percutan Tech 2020 Jun;30(3):285-289

Ministry of Health, University of Health Science, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.

Background: Xanthogranulomatous cholecystitis (XGC) is an uncommon, focal, or diffuse destructive inflammatory disease of the gallbladder mimicking or being together with the gallbladder carcinoma. This study aimed to evaluate the diagnosis, treatment, and outcomes of patients with XGC as a single tertiary center experience in the light of literature.

Materials And Methods: Data about 34 patients with XGC identified after evaluating 2212 cholecystectomy specimens between January 2013 and December 2018 in a single tertiary center were documented to determine demographics (sex, age), clinical symptoms and findings, biochemical and imaging clues and operative findings, duration of hospitalization, postoperative complications, and histopathologic results. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000781DOI Listing

[Undifferentiated Carcinoma of the Gallbladder with Rapid Postoperative Progression-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2524-2526

Dept. of Hepato-Biliary-Pancreatic Surgery, Osaka City General Hospital.

A 74-year-old woman presented with epigastric pain. Imaging revealed a tumor measuring 80 mm, with internal necrosis, originating from the gallbladder and invading the liver. We performed extended anterior segmentectomy of the liver and lymph node resection following a preoperative diagnosis of gallbladder cancer. Read More

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December 2019

The Role of 18F-FDG PET/CT in staging of gallbladder carcinomas.

Turk J Gastroenterol 2020 Feb;31(2):105-112

Department of Nuclear Medicine, University of Health and Sciences, Istanbul Training and Research Hospital, İstanbul, Turkey.

Background/aims: Gallbladder Carcinoma (GBC) is the most common and aggressive tumor of the biliary tract. Patients are typically diagnosed during advanced stages, and the mean overall survival is short. In our study, we aimed to demonstrate the uptake patterns of 18F-FDG PET/CT in GBC, as well as its association with survival and diagnostic value during the initial stage. Read More

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http://dx.doi.org/10.5152/tjg.2020.19410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062135PMC
February 2020

One Hole, Two Tubes, and a Tijuana Pathology Report: A Case Report of Cholecystoduodenal Fistula Mistaken for Gallbladder Cancer.

Cureus 2020 Jan 28;12(1):e6802. Epub 2020 Jan 28.

General Surgery, Community Memorial Hospital, Ventura, USA.

We report a case of a patient who presented with biliary colic while in Tijuana, Mexico. Laparoscopic cholecystectomy was attempted but abandoned and only a biopsy of the gallbladder was performed with pathologist reporting gallbladder adenocarcinoma. Upon return to the United States, extensive evaluation was undertaken including imaging, biopsy, and ultimately two separate exploratory surgeries revealing no neoplasm. Read More

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http://dx.doi.org/10.7759/cureus.6802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045989PMC
January 2020

Flushing as atypical initial presentation of functional gallbladder neuroendocrine carcinoma: A case report.

World J Gastroenterol 2020 Feb;26(6):686-695

Department of General Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China.

Background: Neuroendocrine neoplasms are rarely located in the gallbladder (GB), and carcinoid syndrome is exceedingly rare in patients with GB neuroendocrine neoplasms.

Case Summary: We report a case of GB neuroendocrine carcinoma (GB-NEC) in a 65-year-old man, who presented with flushing for 2 mo. Pathological specimens of the flushed skin revealed that mucin was deposited between the collagen bundles in the dermis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i6.686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029351PMC
February 2020

Subphrenic abscess due to Clostridium perfringens after hepatic resection for hepatocellular carcinoma following emphysematous cholecystitis: Report of a case.

Int J Surg Case Rep 2020 27;67:86-90. Epub 2020 Jan 27.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background: Subphrenic abscess caused by Clostridium perfringens is rare after hepatic resection. We herein report such a case after hepatic resection for hepatocellular carcinoma following treatment of emphysematous cholecystitis.

Case Presentation: A 69-years-old man with chronic hepatitis B, was admitted to our hospital for right subcostal pain and loss of appetite. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015821PMC
January 2020

Computed Tomography and Magnetic Resonance Imaging in the Diagnosis of Primary Neuroendocrine Tumors of the Liver.

World Neurosurg 2020 Jun 30;138:723-731. Epub 2020 Jan 30.

Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou City, Fujian Province, China. Electronic address:

We selected 992 patients who presented to our hospital for treatment and were diagnosed with a neuroendocrine tumor (NET) between January 1, 2008, and December 31, 2018, of whom 17 were diagnosed with primary hepatic neuroendocrine neoplasm. The clinical data were analyzed to study the clinical value of computed tomography (CT) and magnetic resonance imaging data in the diagnosis of the disease. Nine tumors (52. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.169DOI Listing

Analyses of clinical efficacy of ultrasound-guided radiofrequency ablation in liver cancer adjacent to the gallbladder and its prognosis.

J BUON 2019 Nov-Dec;24(6):2411-2417

Department of Ultrasound, Hubei Maternal and Child Health Hospital, Wuhan 430070, China.

Purpose: To explore the clinical efficacy of ultrasound-guided radiofrequency ablation (RFA) in liver cancer adjacent to the gallbladder and to analyze its prognosis.

Methods: 80 patients with liver cancer adjacent to the gallbladder, who were admitted to our hospital from January 2015 to April 2018, were enrolled and divided into the Observation group (n=40) and the Control group (n=40). All of the patients underwent cholecystectomy and lymph node dissection combined with postoperative chemotherapy. Read More

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Rapidly growing neuroendocrine carcinoma of the gallbladder: A case report.

Radiol Case Rep 2020 Mar 10;15(3):259-265. Epub 2020 Jan 10.

Department of Anatomic Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan.

Gallbladder neuroendocrine carcinomas are rare tumors with a prognosis poorer than that of other gallbladder carcinomas. These tumors are often detected late and are difficult to treat. We present the case of a 68-year-old woman with small-cell gallbladder neuroendocrine carcinoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957802PMC

Prognostic and clinicopathologic significance of AEG-1/MTDH and E-cadherin expression in human gallbladder carcinoma.

Int J Clin Exp Pathol 2018 1;11(12):6025-6031. Epub 2018 Dec 1.

Department of Pathology, Taicang Affiliated Hospital of Soochow University Taicang, Jiangsu, PR China.

Astrocyte elevated gene-1 (AEG-1) and E-cadherin are associated with tumorigenesis and progression. The aim of this study is to investigate the expression of AEG-1 and E-cadherin in human gallbladder cancer (GBC) and explore their clinical and pathological significance. The expression of AEG-1 and E-cadherin protein were detected in 71 cases of human GBC and 22 cases of tumor-adjacent tissue by the immunohistochemical method. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963071PMC
December 2018

Type VI choledochal cyst with gall bladder carcinoma.

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

An isolated dilatation of the cystic duct (type VI choledochal cyst (CDC)) is extremely rare with only 21 cases reported in the world literature until now. There is only one case of in situ gall bladder cancer (GBC) reported in association with type VI CDC in the literature. Here we are reporting a case of type VI CDC with papillary GBC. Read More

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http://dx.doi.org/10.1136/bcr-2019-232715DOI Listing
December 2019

Symptomatic Biliary Disorders During Lenvatinib Treatment for Thyroid Cancer: An Underestimated Problem.

Thyroid 2020 Feb 28;30(2):229-236. Epub 2020 Jan 28.

Oncological Endocrinology Unit, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

The prognosis of several human malignancies has dramatically improved after the introduction of tyrosine kinase inhibitors (TKIs); however, their use has been associated with a large spectrum of adverse events, including symptomatic biliary disorders. In the phase III trial of lenvatinib in radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) patients, gallbladder (GB) and biliary duct (BD) diseases and complications were reported. We evaluated symptomatic biliary disorders during treatment with lenvatinib in real-life practice to provide a more exhaustive understanding of its toxicity. Read More

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http://dx.doi.org/10.1089/thy.2019.0355DOI Listing
February 2020

SPECT/CT Demonstrating 131I Accumulation in Gallbladder Stone in a Thyroid Cancer Patient.

Clin Nucl Med 2020 Mar;45(3):244-245

From the Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; and Hubei Key Laboratory of Molecular Imaging, Wuhan, China.

The radioiodine in the gallbladder usually mimics focal hepatic activity on the planar I whole-body scintigraphy. Here we describe an abnormal uptake in the hepatic region on postablative I scintigraphy in a 37-year-old woman with papillary thyroid cancer. The SPECT/CT images revealed this "hepatic activity" corresponded to gallbladder stone. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002875DOI Listing

A review of changes to and clinical implications of the eighth TNM classification of hepatobiliary and pancreatic cancers.

Jpn J Clin Oncol 2019 Dec;49(12):1073-1082

Department of Medical Oncology, Kyorin University Faculty of Medicine, Japan.

Hepatobiliary and pancreatic cancers have poor outcomes. Clinical staging is useful for predicting survival and selecting treatment options. The 8th edition of tumor-node metastasis (TNM) was published in 2016 and came into effect from 2018. Read More

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http://dx.doi.org/10.1093/jjco/hyz150DOI Listing
December 2019

Incidental Carcinoma Gallbladder: Incidence, Risk Factors, and Factors Affecting Survival-5-Year Experience from a Tertiary Care Institute.

J Gastrointest Cancer 2019 Dec 5. Epub 2019 Dec 5.

Department of Surgical Disciplines, All India Institute of Medical Sciences, Room no. 5025, 5th Floor, Ansari Nagar, New Delhi, 110029, India.

Introduction: Carcinoma gallbladder is a very lethal disease. It can get detected incidentally after laparoscopic cholecystectomy. The overall outcome of incidentally detected carcinoma gallbladder is a matter of debate in literature. Read More

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http://dx.doi.org/10.1007/s12029-019-00347-1DOI Listing
December 2019

Early-stage T1b adenocarcinoma arising in the remnant cystic duct after laparoscopic cholecystectomy: a case report and literature review.

BMC Surg 2019 Nov 29;19(1):183. Epub 2019 Nov 29.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City, 951-8510, Japan.

Background: The cystic duct has been included in the staging classification scheme for gallbladder cancer since the 2010 publication of the AJCC Cancer Staging Manual (7th edition). To our knowledge, only seven other cases of adenocarcinoma arising in the remnant cystic duct following cholecystectomy have been reported in the English-language literature, and none has been reported as primary early-stage T1b remnant cystic duct cancer (CDC). We report, herein, a case of primary adenocarcinoma arising in the remnant cystic duct in a patient with history of laparoscopic cholecystectomy for gallstone disease. Read More

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http://dx.doi.org/10.1186/s12893-019-0647-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883593PMC
November 2019

A case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy.

Surg Case Rep 2019 Nov 9;5(1):177. Epub 2019 Nov 9.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: In situ cholangiocarcinoma is difficult to detect by imaging studies. Thus, cholangiocarcinoma is rarely resected with a preoperative definitive diagnosis, especially nonpapillary flat type in situ carcinoma, which is extremely rare.

Case Presentation: A 70-year old man was diagnosed with gallbladder cancer and received open cholecystectomy with lymphadenectomy at a local hospital. Read More

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http://dx.doi.org/10.1186/s40792-019-0745-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842380PMC
November 2019

Catheter-Directed Computed Tomography Hepatic Angiography for Yttrium-90 Selective Internal Radiotherapy of Hepatocellular Carcinoma Reduces Prophylactic Embolization of Extrahepatic Vessels.

Cardiovasc Intervent Radiol 2020 Mar 8;43(3):478-487. Epub 2019 Nov 8.

Office of Academic and Clinical Development, Duke-NUS Medical School, Singapore, Singapore.

Objectives: To determine the rate of prophylactic embolization of extrahepatic vessels in patients undergoing yttrium-90 selective internal radiotherapy (Y SIRT) for hepatocellular carcinoma (HCC) with the use of catheter-directed computed tomography hepatic angiography (CD-CTHA).

Materials And Methods: This retrospective study included 186 HCC patients who received Y SIRT from May 2010 to June 2015 in a single institution. All procedures were performed in a hybrid angiography-CT suite equipped with digital subtraction angiography (DSA) and CD-CTHA capabilities. Read More

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http://dx.doi.org/10.1007/s00270-019-02362-yDOI Listing

Significant response to anti-PD-1 based immunotherapy plus lenvatinib for recurrent intrahepatic cholangiocarcinoma with bone metastasis: A case report and literature review.

Medicine (Baltimore) 2019 Nov;98(45):e17832

Hepatic Surgery Center, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: The prognosis for recurrent intrahepatic cholangiocarcinoma with bone metastasis remains dismal and its treatment poses a challenge for oncologists. To date, only 2 cases were reported in which pembrolizumab, an agent against programmed cell death protein-1 (PD-1), combined with chemotherapy led to a complete response. The safety and efficacy of nivolumab-based immunotherapy combined with lenvatinibin intrahepatic cholangiocarcinoma is unknown. Read More

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http://dx.doi.org/10.1097/MD.0000000000017832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855517PMC
November 2019

Poorly Cohesive Cell Carcinoma of the Gallbladder with Signet Rings and Neuroendocrine-Like Morphology: A Rare Incidental Histopathological Diagnosis with Lessons to Learn.

Am J Case Rep 2019 Oct 23;20:1558-1561. Epub 2019 Oct 23.

Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan.

BACKGROUND Poorly cohesive cell carcinoma of the gallbladder is extremely rare. CASE REPORT Here we present a case of a 46-year-old male with the clinical diagnosis of acute cholecystitis. The ultrasound showed gallbladder wall thickening and multiple stones. Read More

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http://dx.doi.org/10.12659/AJCR.919095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818646PMC
October 2019

Renal Cell Carcinoma Presenting as a Mass of the Gallbladder.

Am Surg 2019 Sep;85(9):e456-e457

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September 2019
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Imaging Features of Primary Sclerosing Cholangitis: From Diagnosis to Liver Transplant Follow-up.

Radiographics 2019 Nov-Dec;39(7):1938-1964. Epub 2019 Oct 18.

From the Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, MRI Room 143, Baltimore, MD 21287 (P.K., R.R.H., B.H., S.A., M.G., M.A.G., A.K., Z.L., I.R.K.); and Department of Radiology, Mayo Clinic Phoenix, Scottsdale, Ariz (C.O.M.).

Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory disease of the bile ducts that leads to multifocal bile duct fibrosis, strictures, cholestasis, liver parenchymal changes, and ultimately cirrhosis. It more commonly occurs in young adults, with a variety of clinical and imaging manifestations. The cause of the disease is not known, but it has a strong association with inflammatory bowel disease and can overlap with other autoimmune diseases, including autoimmune hepatitis and immunoglobulin G4-related disease. Read More

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http://dx.doi.org/10.1148/rg.2019180213DOI Listing
October 2019
4 Reads
2.602 Impact Factor

Is Final Histopathological Examination the Only Diagnostic Criteria for Xanthogranulomatous Cholecystitis?

Niger J Surg 2019 Jul-Dec;25(2):177-182

Department of Surgical Gastroenterology, RMLIMS, Lucknow, Uttar Pradesh, India.

Background: Xanthogranulomatous cholecystitis (XGC) is an uncommon inflammatory disease of gallbladder (GB) and can mimic GB cancer in extensive form. This study aims to assess the predictability of XGC on the basis of clinical presentation, laboratory tests, and radiological or intraoperative findings on frozen section analysis.

Materials And Methods: This is a retrospective study, conducted over a period of 4 years from October 2013 to November 2017. Read More

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http://dx.doi.org/10.4103/njs.NJS_1_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771184PMC
October 2019
2 Reads

Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm: A Rare Association in the Gallbladder.

GE Port J Gastroenterol 2019 Aug 29;26(5):356-361. Epub 2019 Jan 29.

Serviço de Anatomia Patológica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Neuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, and deterioration in the preceding 15 days. Read More

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http://dx.doi.org/10.1159/000495523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751481PMC
August 2019
3 Reads

Staging of Biliary and Primary Liver Tumors: Current Recommendations and Workup.

Surg Oncol Clin N Am 2019 10;28(4):663-683

Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center, 1440 Pressler Street, Unit 1484, Houston, TX 77030, USA. Electronic address:

Hepatobiliary malignancies are a diverse group of neoplasms involving the liver, gallbladder, and bile ducts. Although intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, hepatocellular carcinoma, and gallbladder adenocarcinoma share many biological and anatomic features, they have distinct clinical presentations and natural histories that require individual consideration. Here, we discuss the incidence, outcomes, patient presentation, initial workup, pathologic diagnoses, staging classification, imaging and surgical staging, and determinants of resectability for each malignancy. Read More

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http://dx.doi.org/10.1016/j.soc.2019.06.007DOI Listing
October 2019
6 Reads

Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma.

Chin Clin Oncol 2019 Aug 5;8(4):40. Epub 2019 Aug 5.

Department of Radiology, Division of Interventional Radiology, Weill Cornell Medicine, New York, NY, USA.

Gallbladder carcinoma is a rare, aggressive biliary tract malignancy, with a 5-year survival of less than 5%. It is the 6th most common gastrointestinal malignancy in the United States and more commonly found in women. While some risk factors include gallstones, porcelain gallbladder, and smoking, gallbladder carcinoma is often found incidentally following cholecystectomy or percutaneous image guided biopsy. Read More

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http://dx.doi.org/10.21037/cco.2019.07.09DOI Listing
August 2019
12 Reads

Porcelain Gallbladder: A Case Report.

Mymensingh Med J 2019 Jul;28(3):694-698

Professor Md Mohsen Chowdhury, Professor & Head of Yellow Unit II, Department of Hepatobiliary & Pancreatic Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:

"Porcelain gallbladder" term has been used to highlight the blue staining and fragile consistency of the gallbladder wall at surgery. Some authorities avoid these terms and alternately call all calcified gallbladders "porcelain gallbladders". It is a morphological deviation of chronic cholecystitis. Read More

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July 2019
8 Reads

Cross-sectional Imaging of Gallbladder Carcinoma: An Update.

J Clin Exp Hepatol 2019 May-Jun;9(3):334-344. Epub 2018 Apr 30.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.

Gallbladder Carcinoma (GBCA) is the most common biliary tract malignancy. As the disease is often diagnosed clinically in an advanced stage, the survival rates are dismal. Imaging studies allow for an early diagnosis of malignancy, though the findings may be indistinguishable from non-malignant disease processes affecting the gallbladder. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637089PMC
April 2018
8 Reads

Evaluation of Mucin-producing Gallbladder Carcinoma Using Magnetic Resonance Cholangiopancreatography: A Case Report.

Cureus 2019 May 17;11(5):e4684. Epub 2019 May 17.

Interventional and Diagnostic Radiology, Larkin Community Hospital, Miami, USA.

Mucin-producing gallbladder carcinoma (MPGBC) is a rare and aggressive subtype of gallbladder carcinoma. We present a case of MPGBC with associated magnetic resonance imaging (MRI) / magnetic resonance cholangiopancreatography (MRCP) findings that may raise suspicion of this diagnosis preoperatively. Read More

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http://dx.doi.org/10.7759/cureus.4684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636700PMC
May 2019
3 Reads

Clinical strategies for differentiating IgG4-related cholecystitis from gallbladder carcinoma to avoid unnecessary surgical resection.

Sci China Life Sci 2020 May 17;63(5):764-770. Epub 2019 Jul 17.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of Biliary-Pancreas Surgery, Sun Yat-sen Memorial Hospital, SunYat-sen University, Guangzhou, 510120, China.

Immunoglobulin G4 (IgG4)-related cholecystitis (IgG4-C) is often difficult to distinguish from gallbladder carcinoma (GBC). This study aimed to determine a practical strategy for differentiating between IgG4-C and GBC to avoid unnecessary surgical resection. The expression of IgG4 in the gallbladder was detected by immunohistochemistry. Read More

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http://dx.doi.org/10.1007/s11427-019-9539-6DOI Listing
May 2020
9 Reads

AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.

Clin Gastroenterol Hepatol 2019 11 12;17(12):2416-2422. Epub 2019 Jul 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona; Arizona State University, Phoenix, Arizona.

Description: The purpose of this clinical practice update is to define key principles in the surveillance of hepatobiliary cancers including cholangiocarcinoma, gallbladder adenocarcinoma, and hepatocellular carcinoma in patients with primary sclerosing cholangitis (PSC).

Methods: The recommendations outlined in this expert review are based on available published evidence including observational studies and systematic reviews, and incorporates expert opinion where applicable. BEST PRACTICE ADVICE 1: Surveillance for cholangiocarcinoma and gallbladder cancer should be considered in all adult patients with PSC regardless of disease stage, especially in the first year after diagnosis and in patients with ulcerative colitis and those diagnosed at an older age. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.07.011DOI Listing
November 2019
6 Reads

Prospective multi-center study of surgeon's assessment of the gallbladder compared to histopathological examination to detect incidental malignancy.

Langenbecks Arch Surg 2019 Aug 11;404(5):573-579. Epub 2019 Jul 11.

General Surgery Clinic, Medical Park Fatih Hospital, Fatih, Istanbul, Turkey.

Purpose: Routine histopathological examination after cholecystectomy for gallstones is performed despite the low rates of incidental findings of malignancy. The aim of this study was to assess predictive values of macroscopic examination of cholecystectomy specimens by surgeons in gallstone disease.

Methods: A prospective multi-center diagnostic study was carried out between December 2015 and March 2017 at four different centers. Read More

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http://dx.doi.org/10.1007/s00423-019-01800-2DOI Listing
August 2019
7 Reads

A Case of Acute Pancreatitis Associated with Early-Stage Adenocarcinoma of the Gallbladder.

Am J Case Rep 2019 Jul 4;20:957-960. Epub 2019 Jul 4.

Department of Surgical Oncology, Lehigh Valley Health Network, Allentown, PA, USA.

BACKGROUND Gallstones are a common cause of acute pancreatitis. The proposed mechanism by which choledocholithiasis induces pancreatitis is mechanical obstruction of the ampulla leading to the reflux of bile into the pancreatic duct or edema resulting from a gallstone's passage. To our knowledge, there are no previously reported cases of gallbladder adenocarcinoma as a potential cause of acute pancreatitis. Read More

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http://dx.doi.org/10.12659/AJCR.915543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621932PMC
July 2019
8 Reads

Significance of Metabolic Tumor Volume and Total Lesion Glycolysis Measured Using ¹⁸F-FDG PET/CT in Locally Advanced and Metastatic Gallbladder Carcinoma.

Yonsei Med J 2019 Jul;60(7):604-610

Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study aimed to determine the prognostic value of new quantitative parameters of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally advanced and metastatic gallbladder cancer (GBC).

Materials And Methods: In total, 83 patients initially diagnosed with locally advanced and metastatic GBC and who underwent ¹⁸F-FDG PET/CT at the time of initial diagnosis were retrospectively reviewed. The metabolic volume-based PET parameters of primary tumors and metastatic lesions were measured, including maximum and average standardized uptake values (SUV), MTV, and total lesion glycolysis. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.7.604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597472PMC
July 2019
8 Reads

A Large Carcinosarcoma of the Gallbladder Accompanied by Pancreaticobiliary Maljunction: A Case with a Six-year Survival.

Intern Med 2019 Oct 27;58(19):2809-2817. Epub 2019 Jun 27.

Division of Endoscopy, Shizuoka Cancer Center, Japan.

Pancreatobiliary maljunction (PBM) is a rare congenital malformation, often associated with adenocarcinoma. However, PBM accompanying gallbladder carcinosarcoma has rarely been reported. A 72-year-old woman was referred to our hospital, complaining of abdominal pain. Read More

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http://dx.doi.org/10.2169/internalmedicine.2783-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815897PMC
October 2019
9 Reads

Primary hepaticobiliary tuberculosis mimicking gall bladder carcinoma with liver invasion: a case report.

Pan Afr Med J 2019 7;32:68. Epub 2019 Feb 7.

Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

Primary hepatic tuberculosis is a rare presentation and sporadically reported in the literature, mostly from our part of the world. Sometimes the presentation can be atypical and mimics hepatic tumor and poses diagnostic challenge. We, herein, present a case of a 58-year-old man who presented to us with abdominal pain and weight loss. Read More

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http://dx.doi.org/10.11604/pamj.2019.32.68.10519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560998PMC
July 2019
11 Reads

Cancer risk, screening and surveillance in primary sclerosing cholangitis.

Minerva Gastroenterol Dietol 2019 Sep 19;65(3):214-228. Epub 2019 Jun 19.

Office of University Provost, Arizona State University, Phoenix, AZ, USA.

Primary sclerosing cholangitis (PSC) is a rare chronic inflammatory condition mainly of the large bile ducts, affecting predominantly young men, and is associated with the presence of inflammatory bowel disease. There is no known cure for PSC, which progresses to cirrhosis or death over 10-20 years. Hepatobiliary malignancy, especially cholangiocarcinoma, is a feared complication associated with poor overall survival. Read More

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http://dx.doi.org/10.23736/S1121-421X.19.02586-8DOI Listing
September 2019
23 Reads

[A Case of Conversion Surgery Following Chemotherapy in Initially Unresectable Locally Advanced Gallbladder Carcinoma].

Gan To Kagaku Ryoho 2019 Apr;46(4):775-777

Dept. of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine.

A 47-year-old woman who had unresectable locally advanced gallbladder cancer(GBC)accompanied with liverinvasion, duodenum invasion, transverse colon invasion, and surrounding lymphatic metastasis received 5 courses of chemotherapy with gemcitabine plus cisplatin. Afterthe chemotherapy, imaging showed down-staging of the GBC, indicating tumor shrinkage. The initial laparoscopic examination revealed no peritoneal seeding or distant metastasis. Read More

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April 2019
6 Reads

Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature.

Case Rep Oncol Med 2019 1;2019:8968034. Epub 2019 Apr 1.

Department of Medicine, Bronxcare Health System, Bronx, New York, USA.

The poorly differentiated small-cell type, neuroendocrine carcinoma (NEC) of the gallbladder is a very uncommon subtype of a neuroendocrine tumor of the gastrointestinal tract. Nonsecretory NEC by virtue of its nonspecific and subtle clinical presentation of the tumor is usually diagnosed at an advance stage with presenting symptoms related to either locally advance disease or from metastatic disease. Though the radiologic imaging does identify the gall bladder cancer, the tumor lacks a specific diagnostic test; therefore, the diagnosis is almost always confirmed on histopathologic and immunohistochemical staining. Read More

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http://dx.doi.org/10.1155/2019/8968034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466883PMC
April 2019
8 Reads

Incidental metastases and lymphoma of the gallbladder - an analysis of ten rare cases identified from a large national database.

Scand J Gastroenterol 2019 Mar 30;54(3):350-358. Epub 2019 Apr 30.

a Department of Surgery , Skåne University Hospital , Lund , Sweden.

The aim was to identify and characterize rare malignancies of the gallbladder, incidentally found at cholecystectomy, and describe the diagnostic work-up, treatment and outcome. Data from cholecystectomies during 2007-2014 registered in the Swedish Register for Gallstone Surgery (GallRiks) were analyzed for incidental cancer. For completion of the pathology report, data were linked with the Swedish Registry for Cancer in the liver and biliary tract (SweLiv) and/or the Swedish Cancer Registry. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2019.1
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http://dx.doi.org/10.1080/00365521.2019.1588363DOI Listing
March 2019
32 Reads