7,430 results match your criteria Gallbladder Carcinoma

MicroRNA-197 promotes proliferation and inhibits apoptosis of gallbladder cancer cells by targeting insulin-like growth factor-binding protein 3.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Gallbladder cancer (GBC) is one of the common malignant tumors of the biliary tract. There is no report that miR-197 is involved in GBC.

Objectives: The relationship between miR-197 expression and survival time of GBC patients was analyzed. Read More

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Identification of a novel heterozygous germline RAD52 missense mutation in a patient with gallbladder carcinoma: A case report.

Medicine (Baltimore) 2021 May;100(19):e25957

Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing.

Rationale: Gallbladder carcinoma is a malignant biliary tract tumor which is characterized by poor prognosis. Recent advances in genomic medicine have identified a few novel germline mutations that contribute to the increased risk of gallbladder carcinoma. RAD52 is a crucial human deoxyribonucleic acid (DNA) repair gene involved in maintaining genomic stability and preventing tumor occurrence. Read More

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Towards standardization of management of gallbladder carcinoma with obstructive jaundice: Analysis of 113 cases over 10 years at a single institution.

J Surg Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Medical Gastroenterology, Tata Memorial Hospital, Mumbai, India.

Background: Presence of jaundice in gallbladder carcinoma (GBC) is considered a sign of inoperability with no defined treatment pathways.

Methods: Retrospective analysis of all surgically treated GBC patients from January 2010 to December 2019 was performed for evaluating etiology of obstructive jaundice, resectability, postoperative morbidity, mortality, disease-free survival (DFS) and overall survival (OS).

Results: Out of 954 patients, 521 patients (54. Read More

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Diagnosis and staging of hepatobiliary malignancies: Potential incremental value of (18)F-FDG-PET/MRI compared to MRI of the liver.

Nuklearmedizin 2021 Jun 8. Epub 2021 Jun 8.

Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States.

Objective:  The purpose of the study was to investigate the potential added value of F-FDG-PET/MRI (functional information derived from PET) over standard diagnostic liver MRI (excellent soft tissue characterization) in diagnosing and staging suspected primary hepatobiliary malignancies including extrahepatic cholangiocarcinoma (ECC), intrahepatic cholangiocellular carcinoma (ICC) and gallbladder cancer (GBCA).

Methods:  Twenty consecutive patients with suspected hepatobiliary malignancy were included in this retrospective study. All patients underwent combined whole-body (WB) F-FDG-PET/MRI including contrast-enhanced MRI of the liver, contrast-enhanced WB-MRI and WB F-FDG-PET. Read More

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Polyclonal PAX8 expression in carcinomas of the biliary tract - Frequent non-specific staining represents a potential diagnostic pitfall.

Ann Diagn Pathol 2021 May 26;53:151762. Epub 2021 May 26.

Department of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

Paired box protein 8 (PAX8) is a transcription factor that is considered a relatively specific marker of carcinomas of the thyroid, kidney, and Müllerian/Wolffian duct derivatives. Unexpected PAX8 immunoreactivity has occasionally been reported in other tumors. The frequency of PAX8 expression in carcinomas of the biliary tract is not well studied. Read More

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Robotic Distal Pancreatectomy and Splenectomy for an Intrapancreatic Hepatocellular Carcinoma: A Case Report and Review of the Literature.

J Pancreat Cancer 2020 27;6(1):96-101. Epub 2020 Oct 27.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois, USA.

Liver parenchyma that resides outside of the normal hepatic confines is defined as accessory liver if in communication with the native biliary tree, or ectopic liver (EL) if it is not. EL can develop in a variety of tissues, including but not limited to the gallbladder, the hepatic ligaments, the pancreas, and retroperitoneum. EL has an increased propensity for malignant degeneration resulting in hepatocellular carcinoma (HCC). Read More

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October 2020

Receptor-interacting protein in malignant digestive neoplasms.

J Cancer 2021 19;12(14):4362-4371. Epub 2021 May 19.

Department of General Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, Hubei 430060, China.

A deep and comprehensive understanding of factors that contribute to cancer initiation, progression, and evolution is of essential importance. Among them, the serine/threonine and tyrosine kinase-like kinases, also known as receptor interacting proteins (RIPs) or receptor interacting protein kinases (RIPKs), is emerging as important tumor-related proteins due to its complex regulation of cell survival, apoptosis, and necrosis. In this review, we mainly review the relevance of RIP to various malignant digestive neoplasms, including esophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, gallbladder cancer, cholangiocarcinoma, and pancreatic cancer. Read More

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LncRNA TTN-AS1 acts as a tumor promoter in gallbladder carcinoma by regulating miR-107/HMGA1 axis.

World J Surg Oncol 2021 Jun 5;19(1):163. Epub 2021 Jun 5.

Department of Pathology, Qingdao Municipal Hospital, No. 5 Donghai Middle Road, Shandong Province, Qingdao, 266071, China.

Background: The incidence of gallbladder carcinoma (GBM) in China has increased in recent years. Here, the functional mechanism of lncRNA TTN-AS1 in GBC was preliminary elucidated.

Methods: The expression levels of lncRNA TTN-AS1, miR-107, and HMGA1 in tissues and cell lines were assessed by RT-qPCR. Read More

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Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder.

BMC Gastroenterol 2021 Jun 6;21(1):248. Epub 2021 Jun 6.

Department of Hepatobiliary and Pancreatovascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

Background: Signet ring cell carcinoma (SRC) is a rare histological subtype of gallbladder adenocarcinoma. The current study evaluates the clinicopathologic features and prognosis of SRC.

Methods: Patients with adenocarcinoma of the gallbladder were identified in the Surveillance, Epidemiology, and End Results database from 1973 to 2016. Read More

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Cystic artery pseudoaneurysm due to carcinoma of the gallbladder.

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Surgery, Jawaharlal Institute of Postgraduate Medical Education, Puducherry, Puducherry, India.

A 52-year-old man, with known case of hypertension and stroke, presented to us with an upper gastrointestinal bleed and abdominal pain. Ultrasonography of the abdomen showed haematoma within the gallbladder (GB), and Doppler ultrasound was suggestive of an aneurysm arising from the cystic artery (CA). CT of the abdomen showed a well-enhancing thick-walled GB suggestive of malignancy. Read More

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[Multidisciplinary management of the primary liver cancers].

Rev Med Liege 2021 May;76(5-6):519-524

Service d'Oncologie médicale, CHU Liège,Belgique.

In Belgium and around the world, the incidence of primary malignant liver tumours is increasing, both for hepatocarcinoma and cholangiocarcinoma. Their curative treatment is based on multidisciplinary and specialized care, of which surgery (including liver transplantation) remains the cornerstone, often associated with other logoregional treatments, as radioembolisation, radiofrequency ablation, and chemoembolisation. For advanced cases, the prognosis remains poor, in particular due to a certain chemoresistance of these tumours. Read More

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Metastatic occult breast carcinoma to gallbladder initially presenting as acute cholecystitis.

Kadri Altundag

J BUON 2021 Mar-Apr;26(2):634

MKA Breast Cancer Clinic, Tepe Prime, Cankaya, 06800 Ankara, Turkey.

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Salmonella enterica subsp. enterica host-pathogen interactions and their implications in gallbladder cancer.

Microb Pathog 2021 May 29;157:105011. Epub 2021 May 29.

Department of Molecular and Human Genetics, Jiwaji University, Gwalior, MP, 474001, India.

Background: Several studies have linked chronic typhoid infection with gallbladder carcinoma without completely understood mechanism. This study was performed in order to understand role of Salmonella in gallbladder cancer etiology.

Methods: Known Salmonella host-pathogen interactions were screened from database in addition to known gallbladder carcinoma targets. Read More

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Age, Operation Time, and Surgical Approach can Detect Incidental Gallbladder Carcinoma in Cholecystectomy Specimens from Low-Incidence Settings.

Histopathology 2021 Jun 1. Epub 2021 Jun 1.

Department of Pathology, University of Sherbrooke, Sherbrooke, Canada.

Context: Gallbladders resected for non-neoplastic diseases are systemically examined by microscopy to rule out incidental dysplasia and carcinoma.

Objective: The main objective was to test if a pre-grossing algorithm can detect incidental gallbladder carcinoma. The secondary objective was to test if the algorithm can detect high-grade dysplasia. Read More

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Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis.

Exp Ther Med 2021 Jul 9;22(1):738. Epub 2021 May 9.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Surgical treatment of gallbladder carcinoma remains challenging, while targeted therapy has been demonstrated to have potential. In the present study, the effect of signal transducer and activator of transcription 3 (STAT3) expression and vasculogenic mimicry (VM) on the occurrence and development of gallbladder carcinoma was evaluated. A total of 72 patients with gallbladder carcinoma and 10 patients with chronic cholecystitis were examined. Read More

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First case report of acute cholangitis secondary to Cronobacter sakazakii.

BMC Infect Dis 2021 May 27;21(1):493. Epub 2021 May 27.

King Edward Medical University, Lahore, 54000, Pakistan.

Introduction: Cronobacter sakazakii is an opportunistic Gram-negative, rod-shaped bacterium which may be a causative agent of meningitis in premature infants and enterocolitis and bacteremia in neonates and adults. While there have been multiple cases of C. sakazakii infections, there have been no acute cholangitis cases reported in humans. Read More

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Cholangiocyte senescence in primary sclerosing cholangitis is associated with disease severity and prognosis.

JHEP Rep 2021 Jun 30;3(3):100286. Epub 2021 Mar 30.

Department of Medicine - DIMED, University of Padova, Padua, Italy.

Background & Aims: Primary sclerosing cholangitis (PSC) is a rare cholangiopathy of unknown aetiopathogenesis. The aim of this study was to evaluate cellular senescence (CS) marker expression in cholangiocytes of patients with PSC and their correlation with clinical-pathological features and prognosis.

Methods: Thirty-five patients with PSC with at least 1 available liver sampling were included. Read More

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Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2021 05 1;19(5):541-565. Epub 2021 May 1.

Yale Cancer Center/Smilow Cancer Hospital.

The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts (intrahepatic and extrahepatic cholangiocarcinoma). Due to the multiple modalities that can be used to treat the disease and the complications that can arise from comorbid liver dysfunction, a multidisciplinary evaluation is essential for determining an optimal treatment strategy. A multidisciplinary team should include hepatologists, diagnostic radiologists, interventional radiologists, surgeons, medical oncologists, and pathologists with hepatobiliary cancer expertise. Read More

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Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report.

Ann Med Surg (Lond) 2021 Jun 6;66:102359. Epub 2021 May 6.

General Surgery Department, Mohammed VI University Hospital/Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco.

Introduction And Importance: Neuroendocrine carcinoma of the gallbladder is rare and aggressive, its diagnosis is based on pathologic and immunohistochemical examination, currently there is no standard treatment for this tumor. Its concomitant occurrence with adenocarcinoma of the sigmoid colon is exceptional.

Case Presentation: This case report describes a rare case of neuroendocrine carcinoma of the gallbladder that occurred concomitantly with sigmoid colon adenocarcinoma. Read More

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Psychological Burden and Psycho-Oncological Interventions for Patients With Hepatobiliary Cancers-A Systematic Review.

Front Psychol 2021 5;12:662777. Epub 2021 May 5.

Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.

Background: Worldwide, hepatobiliary cancers are frequent diseases and often accompanied by a poor prognosis. These cancers, with hepatocellular carcinoma (HCC) and cholangiocarcinoma (CHC) being the most frequent, are often associated with a considerable amount of psychological burden such as anxiety, depressiveness, and reduced health-related quality of life (HRQOL) which may lead to psychiatric comorbidities. This systematic review gives an overview on psychological burden and on the effectiveness of psycho-oncological interventions for patients with HCC and CHC. Read More

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IgG4-related cholecystitis mimicking gallbladder carcinoma; the challenge of a preoperative diagnosis.

Gastroenterol Hepatol 2021 May 21. Epub 2021 May 21.

Servicio de Cirugía General y del Aparato Digestivo, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, España.

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Association between Proton Pump Inhibitor Use and Biliary Tract Cancer Risk: a Swedish Population-Based Cohort Study.

Hepatology 2021 May 21. Epub 2021 May 21.

Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Background And Aims: Biliary tract cancer is a group of highly aggressive malignant disorders, yet risk factors are poorly understood. In this study, we aim to assess whether prolonged use of proton pump inhibitors (PPI) increases the risk of incident biliary tract carcinoma in a nationwide population-based cohort in Sweden.

Approach: Using nationwide registries, we identified all adults who received maintenance PPIs (≥180 days) according to the Swedish Prescribed Drug Register from 2005 through 2012. Read More

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Orphan drugs in different countries and development of new drugs to treat biliary tract cancer.

Intractable Rare Dis Res 2021 May;10(2):146-147

Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Biliary tract cancer (BTC), which includes cholangiocarcinoma and gallbladder carcinoma, is a rare malignancy. Due to its low incidence, drugs treating these diseases are scarce, so they can be considered orphan drugs. The main treatment choice for BTC is chemotherapy with gemcitabine or cisplatin or combined use of both, but patients fail to significantly benefit from established chemotherapy. Read More

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Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT.

J Cancer 2021 24;12(12):3548-3557. Epub 2021 Apr 24.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Gallbladder cancer (GBC) is characterized by poor prognosis, early metastasis, and high recurrence rates, which seriously threaten human health. The effect of lenvatinib, a widely used drug in anti-hepatocellular carcinoma in China, on GBC progress, as well as its underlying molecular mechanism, remains unclear. Therefore, the present study investigated the effect of lenvatinib on human GBC GBC-SD and NOZ cells and its underlying mechanisms. Read More

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Percutaneous Cryoablation of Liver Tumors: Initial Experience from a Tertiary Care Center in India.

J Clin Exp Hepatol 2021 May-Jun;11(3):305-311. Epub 2020 Oct 19.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Percutaneous ablation is an important part of management strategy for liver tumors. While radiofrequency ablation and microwave ablation are the most widely used ablative techniques, cryoablation (CA) has several technical advantages but has been underused till recently. In this study, we report the initial experience with percutaneous CA of liver tumors. Read More

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October 2020

Diagnosis of gallbladder duplication with gallbladder carcinoma by magnetic resonance cholangiopancreatography: A case report.

Asian J Surg 2021 May 11. Epub 2021 May 11.

Department of Radiology, Taizhou No.1 People's Hospital of Zhejiang Province, Huangyan, 318020, China.

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Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer.

Hum Pathol 2021 May 11. Epub 2021 May 11.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Invasive gallbladder carcinoma (GBC) is preceded by two main types of precursor lesions: intracholecystic papillary-tubular neoplasms (ICPNs) and biliary intraepithelial neoplasias (BilINs). Invasive GBCs with an ICPN component have more favorable prognoses than those without an ICPN component. Some BilINs show a relatively exophytic papillary pattern but do not meet the ICPN criteria; at our institution, we call these papillary neoplasias. Read More

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Clear-Cell Adenocarcinoma of the Gallbladder with Alpha-Fetoprotein Production: A Case Report and Review of the Literature.

Gastrointest Tumors 2021 Apr 27;8(2):52-57. Epub 2021 Jan 27.

Department of Urology, Indraprashtha Apollo Hospital, Delhi, India.

Gallbladder tumors are the fifth most common cancers of the gastrointestinal tract with poor prognosis and low survival. The most common type is adenocarcinoma of which the clear cell type is an unusual histologic variant with alpha-fetoprotein (AFP)-producing gallbladder carcinoma, reported extremely rarely, which makes the index case an uncommon entity. AFP secretion by gallbladder carcinomas may occur given the similar embryological origin of liver and gallbladder. Read More

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Routine Histopathological Examination of the Specimen After Laparoscopic Cholecystectomy: Can We Be Brave Enough to Give Up?

Turk J Gastroenterol 2021 Feb;32(2):218-224

Department of General Surgery, Gazi University School of Medicine, Ankara, Turkey.

Background: Selective versus routine histopathological examination after cholecystectomy is still in debate. This study aims to investigate the effect of histopathology results on treatment modality and surgery strategy. The validity of the selective histopathology approach was questioned. Read More

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February 2021

Impact of Cholestasis on the Sensitivity of Percutaneous Transluminal Forceps Biopsy in 93 Patients with Suspected Malignant Biliary Stricture.

Cardiovasc Intervent Radiol 2021 May 4. Epub 2021 May 4.

Division of Image Guided Minimally Invasive Surgery, Juan D. Perón 4190 (C1181ACH), Ciudad autónoma de Buenos Aires, Argentina.

Purpose: The aim of this study was to determine the effect of hyperbilirubinemia in the sensitivity of percutaneous transluminal forceps biopsy (PTFB) in patients with suspected malignant biliary stricture.

Materials And Methods: Ninety-three patients with suspicion of malignant biliary stricture underwent percutaneous transhepatic cholangiography followed by PTFB. Sensitivity, specificity and predictive values were analysed based on the presence or absence of hyperbilirubinemia, defined as total bilirubin equal to, or higher than 5 mg/dL. Read More

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