7,774 results match your criteria Gallbladder Carcinoma

The state of therapy modalities in clinic for biliary tract cancer.

Front Biosci (Landmark Ed) 2022 Jun;27(6):185

Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China.

Biliary tract cancers (BTCs) include intrahepatic cholangiocarcinoma (iCCA), perihilar and distal cholangiocarcinoma (pCCA and dCCA), and gallbladder carcinoma based on the epithelial site of origin. BTCs are highly aggressive tumors associated with poor prognosis due to widespread metastasis and high recurrence. Surgery is the typical curative-intent treatment, yet the cornerstone of cure depends on the anatomical site of the primary tumor, and only a minority of patients (approximately 30%) has an indication necessitating surgery. Read More

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Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review.

Diagn Pathol 2022 Jun 17;17(1):51. Epub 2022 Jun 17.

Hospital Information Center of Heilongjiang Province Affiliated to Harbin Institute of Technology, Harbin, 150001, Heilongjiang Province, China.

Background: Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) of the gallbladder are rare malignancies. Here we presented two cases and reviewed the related literature.

Case Presentation: Our two patients were postoperatively diagnosed with gallbladder MiNENs, which pathologically consisted of a large cell neuroendocrine carcinoma and papillary adenocarcinoma. Read More

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Successful Treatment of Metastatic Gallbladder Carcinoma with PD-L1 Expression by the Combination of PD-1 Inhibitor Plus Bevacizumab with Chemotherapy: A Case Report.

Onco Targets Ther 2022 7;15:629-636. Epub 2022 Jun 7.

Department of Oncology, Xi 'an International Medical Center Hospital, Xi 'an, Shaanxi Province, People's Republic of China.

Gallbladder cancer (GBC) is the most common type of biliary tract cancer. The GBC is often diagnosed at an advanced stage, which limits surgical intervention due to its aggressive nature, and as a consequence of its insensitivity to chemotherapy, more effective treatments are required. In GBC, the efficacy of chemotherapy combined with anti-PD-L1/VEGF inhibition remains to be clarified. Read More

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Statins associate with lower risk of biliary tract cancers: A systematic review and meta-analysis.

Cancer Med 2022 Jun 13. Epub 2022 Jun 13.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Background: Biliary tract cancers (BTCs), encompassing cholangiocarcinoma (CCA), gallbladder (GBC), and ampulla of Vater cancers (AVC), are common hepatobiliary cancer after hepatocellular carcinoma with a high mortality rate. As there is no effective chemopreventive agent to prevent BTCs, this study aimed to explore the role of statins on the risk of BTCs.

Methods: PubMed, Embase, and Cochrane Library from inception until 24 April 2020 were searched according to the Meta-Analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Read More

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Role of ERCP in Malignant Hilar Biliary Obstruction.

Gastrointest Endosc Clin N Am 2022 Jul 11;32(3):427-453. Epub 2022 May 11.

Department of Medicine, Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indiana University Health-University Hospital, 550 North University Boulevard, Suite 1634, Indianapolis, IN 46202, USA.

Malignant hilar biliary obstruction (MHO), an aggressive perihilar biliary obstruction caused by cholangiocarcinoma, gallbladder cancer, or other metastatic malignancies, has a poor prognosis. Surgical resection is the only curative treatment method for biliary malignancies. However, most of the patients with MHO cannot undergo surgeries on presentation because of an advanced inoperable state or a poor performance state due to old age or comorbid diseases. Read More

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Laparoscopic hepatopancreaticoduodenectomy for synchronous gallbladder cancer and extrahepatic cholangiocarcinoma: a case report.

Guo-Liang Yao

World J Surg Oncol 2022 Jun 9;20(1):190. Epub 2022 Jun 9.

Department of General Surgery, The First Affiliated Hospital of Henan University of Science and Technology, 24 Jinghua road, Luoyang, 471000, China.

Background: Hepatopancreaticoduodenectomy (HPD) is one of the most complex procedures, and it is very rarely reported. Laparoscopic HPD (LHPD) is even rarer. To date, there are only 3 reports of LHPD for locally advanced gallbladder cancer (GBC) or extrahepatic cholangiocarcinoma (ECC). Read More

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Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study.

Int J Colorectal Dis 2022 Jun 9. Epub 2022 Jun 9.

School of Basic Medical Sciences, Chongqing Three Gorges Medical College, Chongqing, 404120, China.

Background: The relationship between the location of the primary tumor and survival of adenosquamous carcinoma (ASC) remains poorly understood. This study aimed to evaluate the impact of primary tumor location on the survival outcome of patients with ASC.

Methods: Patients with ASC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database with ≥ 150 cases per tumor location. Read More

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Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor.

Hepatobiliary Pancreat Dis Int 2022 May 24. Epub 2022 May 24.

Department of Surgery, Gold Coast University Hospital, Southport, QLD 4215, Australia.

Background: Despite remarkable advances in surgical techniques and perioperative management, left hepatic trisectionectomy (LHT) remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive resections. This study aimed to analyze the short- and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical procedure.

Methods: The medical records of 53 patients who underwent LHT between June 2005 and October 2019 at a single institution were retrospectively reviewed. Read More

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Clinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract Cancer Reveals Subtype-Specific Immune Signatures.

JCO Precis Oncol 2022 Jun;6:e2100510

Johns Hopkins University, Baltimore, MD.

Purpose: Biliary tract cancers (BTCs) are aggressive cancers that carry a poor prognosis. An enhanced understanding of the immune landscape of anatomically and molecularly defined subsets of BTC may improve patient selection for immunotherapy and inform immune-based combination treatment strategies.

Methods: We analyzed deidentified clinical, genomic, and transcriptomic data from the Tempus database to determine the mutational frequency and mutational clustering across the three major BTC subtypes (intrahepatic cholangiocarcinoma [IHC], extrahepatic cholangiocarcinoma, and gallbladder cancer). Read More

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Cell-Free Tumor DNA Dominant Clone Allele Frequency Is Associated With Poor Outcomes in Advanced Biliary Cancers Treated With Platinum-Based Chemotherapy.

JCO Precis Oncol 2022 Jun;6:e2100274

Division of Hematology & Oncology, Department of Medicine, Mayo Clinic, Scottsdale, AZ.

Purpose: This investigation sought to evaluate the prognostic value of pretreatment of circulating tumor DNA (ctDNA) in metastatic biliary tract cancers (BTCs) treated with platinum-based first-line chemotherapy treatment.

Materials And Methods: We performed a retrospective analysis of 67 patients who underwent ctDNA testing before platinum-based chemotherapy for first-line treatment for metastatic BTC. For analysis, we considered the detected gene with highest variant allele frequency as the dominant clone allele frequency (DCAF). Read More

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Early Recurrence in Resected Gallbladder Carcinoma: Clinical Impact and Its Preoperative Predictive Score.

Ann Surg Oncol 2022 Jun 6. Epub 2022 Jun 6.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Sunto-Nagaizumi, Shizuoka, Japan.

Background: Surgical resection is the only potentially curative therapy for gallbladder carcinoma (GBC). However, the postoperative recurrence rate is high (approximately 50%), and recurrence occasionally develops early after surgery.

Patients And Methods: A total of 139 patients who underwent macroscopically curative resection for GBC between 2002 and 2018 were retrospectively reviewed. Read More

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Case reports: chemoradiotherapy for locally advanced neuroendocrine carcinoma of the gallbladder.

Clin J Gastroenterol 2022 Jun 2. Epub 2022 Jun 2.

Department of Oncology, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan.

Neuroendocrine carcinoma (NEC) is a rare subtype of malignant gallbladder tumor. Although surgical resection is the only potentially curative therapy for gallbladder NEC, most cases are surgically unresectable because of advanced stage disease and/or biologically aggressive behavior. The standard palliative treatment for malignant gallbladder tumors is chemotherapy; however, the efficacy of chemoradiotherapy in the treatment of gallbladder tumors is controversial. Read More

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A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder.

Case Rep Oncol Med 2022 21;2022:6956046. Epub 2022 May 21.

Department of Pathology, University of South Alabama Health, Mobile, Alabama 36617, USA.

Primary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically "pure" LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs present with abdominal pain and jaundice and follow an aggressive course with patients surviving a median of 15 months following initial diagnosis. Read More

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Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis.

BMC Microbiol 2022 May 27;22(1):147. Epub 2022 May 27.

Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima, Japan.

Background: The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However, reports characterizing the bile microbiota are rare. This study aims to investigate the microbiota composition in patients with pancreaticobiliary cancers and benign diseases by 16S rRNA gene amplicon sequencing and to evaluate its potential value as a biomarker for the cancer of the bile duct, pancreas, and gallbladder. Read More

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Contrast-enhanced CT radiomics for prediction of recurrence-free survival in gallbladder carcinoma after surgical resection.

Eur Radiol 2022 May 25. Epub 2022 May 25.

Department of Hepatobiliary Pancreatic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Objectives: Gallbladder carcinoma (GBC) is the most common and aggressive biliary tract malignancy with high postoperative recurrence rates. This single-center study aimed to develop and validate a radiomics signature to estimate GBC recurrence-free survival (RFS).

Methods: This study retrospectively included 204 consecutive patients with pathologically diagnosed GBC and were randomly divided into development (n = 142) and validation (n = 62) cohorts (7:3). Read More

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Value of Multislice Spiral CT in Differential Diagnosis of Thick-Wall Gallbladder Carcinoma and Chronic Cholecystitis.

Hua Han Jun Han

Contrast Media Mol Imaging 2022 6;2022:5459779. Epub 2022 May 6.

Department of Radiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.

To summarize the value of multislice spiral CT (MSCT) in the differential diagnosis of thick-wall gallbladder carcinoma (TWGC) and chronic cholecystitis (CC), the clinical data of 36 patients with TWGC and 60 patients with chronic cholecystitis who were treated in our hospital from January 2017 to May 2021 were retrospectively analyzed, and the CT image features and diagnostic accuracy of the patients were summarized. Compared with the CC group, the proportions of disruption of gallbladder mucosa line, blurred gallbladder outline, high obstruction of biliary tract, lymphomegaly, adjacent invasion, peritoneal effusion, wall nodules, and the gallbladder wall thickness in the TWGC group were higher, with statistical significance ( < 0.05). Read More

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A Novel Clinically Prognostic Stratification Based on Prognostic Nutritional Index Status and Histological Grade in Patients With Gallbladder Cancer After Radical Surgery.

Front Nutr 2022 4;9:850971. Epub 2022 May 4.

Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Purpose: Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract, with a 5-year survival rate of 5%. The prognostic models to predict the prognosis of patients with GBC remain controversial. Therefore, to construct a prognosis prediction of GBC, a retrospective cohort study was carried out to investigate the prognostic nutritional index and histological grade in the long-term outcome of patients with GBC after radical surgery (RS). Read More

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Primary mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: A case report and literature review.

Asian J Surg 2022 May 19. Epub 2022 May 19.

Department of Radiation Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, Liaoning Province, China. Electronic address:

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Clinical Characteristics and Outcome Between Gallbladder Squamous Cell Carcinoma and Adenocarcinoma: A Propensity Matched Analysis Based on the Surveillance, Epidemiology, and End Results Database.

Front Oncol 2022 2;12:833447. Epub 2022 May 2.

Department of Abdominal Cancer, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.

Background: Gallbladder squamous cell carcinoma (GSCC) is a rare carcinoma with limited evidence in literature, making it particularly difficult to study. Surveillance, Epidemiology, and End Results Database (SEER) were used to stress the clinicopathological features and outcomes associated with this tumor.

Methods: SEER registries were used to identify GSCC and gallbladder adenocarcinoma (GAC) cases from 2004 to 2015. Read More

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Mixed adenoneuroendocrine carcinoma of the gallbladder with hepatic metastasis: A case report.

Asian J Surg 2022 May 15. Epub 2022 May 15.

Department of Gastroenterology, Ganzhou Fifth People's Hospital, Ganzhou, China. Electronic address:

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Is the tumor-stroma ratio a prognostic factor in gallbladder cancer?

Rev Assoc Med Bras (1992) 2022 May;68(5):664-669

University of Health Sciences Turkey, Haydarpasa Numune Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.

Objective: This study aimed to examine the prognostic effect of the tumor-stroma ratio, which has been shown to have prognostic value in various cancers, in patients with gallbladder cancer who have undergone curative resection.

Methods: The records of gallbladder cancer patients who underwent surgical treatment in our clinic between December 2005 and March 2021 were analyzed retrospectively. The hematoxylin and eosin-stained sections representing the tumors were evaluated under light microscopy to determine tumor-stroma ratio, and based on the results, <50% was defined as the stroma-rich and ≥50% as the stroma-poor groups. Read More

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Comparison of the Oncological Outcomes of Open versus Laparoscopic Surgery for T2 Gallbladder Cancer: A Propensity-Score-Matched Analysis.

J Clin Med 2022 May 8;11(9). Epub 2022 May 8.

Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, 79, Gangnam-ro, Jinju 52727, Korea.

Although laparoscopic treatment for T1 gallbladder cancer (GBC) has been described previously, the differences in oncologic outcomes between laparoscopic and conventional open surgery for T2 GBC have not been investigated. We aimed to assess the role of laparoscopic surgery using retrospectively collected data for 81 patients with T2 GBC who underwent surgical resection between January 2010 and December 2017. Eligible patients were classified into "laparoscopic" and "open" groups. Read More

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The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.

Virchows Arch 2022 May 13. Epub 2022 May 13.

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 12800, Prague 2, Czech Republic.

We assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from the gastrointestinal tract (GIT) and the significance of CK17 expression in a broad spectrum of primary ovarian tumors with respect to their prognosis. The sample set consisted of 554 primary ovarian tumors and 255 GIT tumors. In the primary ovarian tumors, a higher CK17 expression (in > 10% of tumors cells) was present only in 0-11. Read More

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Unusual presentation of small cell carcinoma with diffuse tracheal wall thickening leading to delayed diagnosis.

BMJ Case Rep 2022 05 12;15(5). Epub 2022 May 12.

Hematology/Oncology, Feist-Weiller Cancer Center, Shreveport, Louisiana, USA.

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A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps.

J Clin Transl Hepatol 2022 Apr 30;10(2):263-272. Epub 2021 Jun 30.

Department of Hepato-biliary-pancreatic Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.

Background And Aims: Gallbladder polyp (GBP) assessment aims to identify the early stages of gallbladder carcinoma. Many studies have analyzed the risk factors for malignant GBPs. In this retrospective study, we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs. Read More

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Gallbladder Neuroendocrine Tumors: Is There a Need for a Specific Approach?

Gastrointest Tumors 2022 Mar 18;9(1):5-11. Epub 2021 Nov 18.

Department of Surgical Gastroenterology & HPB Surgery, Jaslok Hospital and Research Centre, Mumbai, India.

Neuroendocrine tumors (NETs) of the gallbladder or the biliary tree are rare. Most of the current guidelines and protocols are derived from the experience of managing lung small cell neuroendocrine carcinoma or gastrointestinal NETs. But, the overall outcome of gallbladder NETs (GB-NETs) seems worse than similarly staged lung NETs and adenocarcinoma of the gallbladder. Read More

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Synchronous gallbladder metastasis originating from residual gastric cancer: a case report and the review of literature.

Surg Case Rep 2022 May 7;8(1):88. Epub 2022 May 7.

Department of Surgery, Matsuyama Red Cross Hospital, 1, Bunkyo-cho, Matsuyama, Ehime, 790-8524, Japan.

Background: Gastric cancer rarely metastasizes to the gallbladder. Furthermore, there has never been a case report of simultaneous gallbladder metastasis from residual gastric cancer. Here, we report a case of synchronous gallbladder metastasis originating from a residual gastric cancer. Read More

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Primary Large Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Gallbladder.

Cureus 2022 Apr 4;14(4):e23799. Epub 2022 Apr 4.

General Surgery, Asklipieio Voulas Hospital, Athens, GRC.

Primary lymphoma of the gallbladder (GB) is a rare condition, and very few cases have been reported so far. Diagnosis is usually made after surgery of suspicious GB mass, which is often difficult to differentiate from GB carcinoma. The GB wall does not contain lymphoid tissue, and tumors arise at the submucosal layer. Read More

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Xanthogranulomatous Cholecystitis Masquerading as Gallbladder Carcinoma on 68Ga-FAPI-04 PET.

Clin Nucl Med 2022 Apr 29. Epub 2022 Apr 29.

From the Department of Nuclear Medicine, Changhai Hospital, Navy Military Medical University.

Abstract: 68Ga-FAPI-04 has great potential for the detection and staging evaluation of a variety of tumors. We report a case of suspected gallbladder carcinoma that was enrolled in a prospective study of 68Ga-FAPI-04 imaging at our institution. This case was later histopathologically confirmed as xanthogranulomatous cholecystitis. Read More

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