6,693 results match your criteria Gallbladder Carcinoma


Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies.

World J Gastroenterol 2019 Feb;25(6):659-671

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra- and/or extrahepatic biliary ducts. While its features and disease course can be variable, most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378537PMC
February 2019

Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
February 2019
1 Read

[A Case of Abdominal Compartment Syndrome after Laparotomy for Peritonitis Caused by Colon Perforation Due to Gallbladder Carcinoma].

Gan To Kagaku Ryoho 2019 Jan;46(1):157-159

Dept. of Surgery, Kansai Medical University.

A70 -year-old man with a diagnosis of panperitonitis caused by colon perforation due to invasion of gallbladder cancer was transferred to our hospital. The next day, an emergency operation was performed. During laparotomy, the ascending colon was perforated; therefore, ileocecal resection was performed. Read More

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January 2019
1 Read

Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.

J Gastrointest Surg 2019 Feb 12. Epub 2019 Feb 12.

Section of Hepatobiliary and Pancreatic Surgery, Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Background: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease.

Materials And Methods: We maintain a prospective high volume gastrointestinal malignancy PDX program. Read More

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http://dx.doi.org/10.1007/s11605-019-04109-zDOI Listing
February 2019
1 Read

Elucidation of the chemopreventive role of stigmasterol against Jab1 in Gall bladder carcinoma.

Endocr Metab Immune Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow. India.

Background: Plant sterols have proven a potent anti-proliferative and apoptosis inducing agent against several carcinomas including breast and prostate cancers. Jab1 has been reported to be involved in the progression of numerous carcinomas. However, antiproliferative effects of sterols against Jab1 in gall bladder cancer have not been explored yet. Read More

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http://dx.doi.org/10.2174/1871530319666190206124120DOI Listing
February 2019
2 Reads

Systematically Characterizing Chemical Profile and Potential Mechanisms of Qingre Lidan Decoction Acting on Cholelithiasis by Integrating UHPLC-QTOF-MS and Network Target Analysis.

Evid Based Complement Alternat Med 2019 3;2019:2675287. Epub 2019 Jan 3.

Institute of Integrative Medicine, Dalian Medical University, No. 9, South Road of Lvshun, Dalian 116044, China.

Qingre Lidan Decoction (QRLDD), a classic precompounded prescription, is widely used as an effective treatment for cholelithiasis clinically. However, its chemical profile and mechanism have not been characterized and elucidated. In the present study, a rapid, sensitive, and reliable ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established for comprehensively identifying the major constituents in QRLDD. Read More

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http://dx.doi.org/10.1155/2019/2675287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335670PMC
January 2019
1 Read

Neuroendocrine carcinoma of gallbladder: a case series and literature review.

Eur J Med Res 2019 Feb 4;24(1). Epub 2019 Feb 4.

Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic of China.

Background: Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported.

Case Presentation: Eight gallbladder NEC patients were admitted into our hospital. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-019-0363-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362567PMC
February 2019
4 Reads

Long non-coding RNA DILC promotes the progression of gallbladder carcinoma.

Gene 2019 Feb 1;694:102-110. Epub 2019 Feb 1.

Department of Biliary Tract Surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai 200438, China. Electronic address:

Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) contribute to tumorigenesis, progression and recurrence of various malignancies including Gallbladder carcinoma (GBC). Lnc-DILC is reported to be the tumor suppressor gene to play an important role in liver cancer stem cells (CSCs). However, the role of lnc-DILC in GBC remains to be elucidated. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.086DOI Listing
February 2019
1 Read

Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report.

Surg Case Rep 2019 Feb 4;5(1):17. Epub 2019 Feb 4.

Department of Surgery, Maizuru Medical Center, Kyoto, Japan.

Background: Metastases to the stomach or gallbladder from any malignancy is rarely noted, and simultaneous metastases to both organs are atypical. We present a unique case of simultaneous multifocal metastases of the stomach and gallbladder from renal cell carcinoma (RCC).

Case Presentation: The case involved a 60-year-old man, with a past history of RCC (clear cell type, G2, T1b N0 M0 Stage I) treated by a right nephrectomy. Read More

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http://dx.doi.org/10.1186/s40792-019-0569-xDOI Listing
February 2019
1 Read

Surgical treatment of malignant biliary papillomatosis invading adjacent organs: A case report.

World J Clin Cases 2019 Jan;7(2):253-259

Department of Plastic and Burn Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Biliary papillomatosis (BP) is a rare disease characterized by multiple papillary adenomas in the intrahepatic and extrahepatic biliary tree and has a high risk of malignant transformation. Early diagnosis and treatment for BP are challenges, as it spreads along the biliary tract. A radical resection with an adequate resection margin is advocated in patients with malignant BP. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i2.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354098PMC
January 2019
1 Read

Gallbladder metastasis from renal cell carcinoma: A case report and literature review.

Urol Case Rep 2019 Mar 8;23:69-71. Epub 2019 Jan 8.

Department of Urology, Daiyukai Daiichi Hospital, 1-6-12 Hagoromo, Ichinomiya City, Aichi, 491-0025, Japan.

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http://dx.doi.org/10.1016/j.eucr.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348693PMC
March 2019
1 Read

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study.

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

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http://dx.doi.org/10.2196/10677DOI Listing
January 2019
2 Reads
3.428 Impact Factor

Laparoscopic Excisional Cholecystectomy with Full-Thickness Frozen Biopsy in Suspected Gallbladder Carcinoma.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):747-756. Epub 2018 Dec 13.

Division of Surgery, Gastroenterological Center, Medico Shunju Shiroyama Hospital, Osaka, Japan.

Owing to the advantages of a laparoscopic approach, laparoscopic cholecystectomy (LC) is thought to be the treatment of choice in gallbladder disease, even in cases of suspected malignancy. However, it is difficult to differentiate between cholecystitis and gallbladder carcinoma (GBC). We performed radical hepatectomy in patients with pT2 GBC diagnosed by full-thickness frozen biopsy. Read More

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http://dx.doi.org/10.1159/000495603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341341PMC
December 2018
5 Reads

Immune-related adverse events predict the therapeutic efficacy of anti-PD-1 antibodies in cancer patients.

Eur J Cancer 2019 Jan 22;109:21-27. Epub 2019 Jan 22.

Medical Oncology Department, Instituto de Investigación Sanitaria la Princesa, HU La Princesa, Madrid, Spain. Electronic address:

Background: Cancer immune therapy has shown remarkable benefit in the treatment of a range of cancer types, although it may initiate autoimmune-related disorders in some patients. We have attempted to establish whether the incidence of irAEs after the use of anti-PD-1 antibodies nivolumab or pembrolizumab in advanced malignancies is associated with anti-PD-1 treatment efficacy.

Patients And Methods: We studied patients treated with single-agent nivolumab or pembrolizumab for advanced cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183145
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http://dx.doi.org/10.1016/j.ejca.2018.10.014DOI Listing
January 2019
5 Reads

Efficacy and Safety of Microwave Ablation (MWA) for Hepatocellular Carcinoma (HCC) in Difficult Anatomical Sites in Egyptian Patients with Liver Cirrhosis

Asian Pac J Cancer Prev 2019 Jan 25;20(1):295-301. Epub 2019 Jan 25.

Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. Email:

Background and aim: Imaging guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) has become a widely used method over recent years. Tumors close to the diaphragm, gastrointestinal tract, gallbladder, pancreas, hepatic hilum and major bile duct or vessels are generally considered relative contraindications for microwave ablation. This study was conducted to assess the effectiveness and safety of ultrasonography-guided MWA in treating patients with HCC in difficult anatomical sites in comparison to those in conventional sites. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.295DOI Listing
January 2019
1 Read

Gallbladder carcinoma. Surgical management of gallblad-der carcinoma. An analysis of 37 cases.

Ann Ital Chir 2018 ;89:501-506

Background & Aims: Gallbladder carcinoma is a rare yet very aggressive cancer. In this study we evaluate the presentation, staging, procedures, complications and survival of patients with gallbladder carcinoma.

Material And Methods: Data at presentation, operative findings, postoperative evolution, complications and survival data were analyzed for 37 patients with gallbladder carcinoma (as cohort study) confirmed at histopathology between January 2005 and December 2011 in Surgical Department of Regional Institute of Gastroenterology And Hepatology "Octavian Fodor" Cluj-Napoca, Romania. Read More

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January 2018
2 Reads

A Case of Tubular Adenoma of Gallbladder Diagnosed Using Contrast-Enhanced Ultrasonography.

J Med Ultrasound 2018 Oct-Dec;26(4):218-221. Epub 2018 Aug 24.

Division of Ultrasound and Breast Imaging, Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.

Contrast-enhanced ultrasound (CEUS) has been used to diagnose gallbladder (GB) diseases for recent years because it is sensitive to visualize vascularity. Herein, we report a case who had a 1.7 cm × 1. Read More

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http://dx.doi.org/10.4103/JMU.JMU_47_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314087PMC

Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.

Cancer Chemother Pharmacol 2019 Jan 18. Epub 2019 Jan 18.

Product Research Department, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa, 247-8530, Japan.

Purpose: Trastuzumab emtansine (T-DM1) provides clinical benefit in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2). However, its efficacy against biliary tract cancers (BTC) has not been evaluated. In this study, the effectiveness of T-DM1 in various BTC cell lines and xenograft models with different levels of HER2 expression was investigated. Read More

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http://link.springer.com/10.1007/s00280-019-03768-8
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http://dx.doi.org/10.1007/s00280-019-03768-8DOI Listing
January 2019
6 Reads

Decreased liver stiffness by transient elastography indicates lower incidence of hepatocellular carcinoma in patients with chronic hepatitis B.

Medicine (Baltimore) 2019 Jan;98(3):e13929

Department of Gastroenterology, Jining No 1 People's Hospital, Jining, Shandong.

The prognositc value of dynamic liver stiffness (LS) variation on hepatocellular carcinoma (HCC) incidence in patients with chronic hepatitis B (CHB) remains to be explored. We aim to compare HCC incidence in patients with compensated CHB-related cirrhosis with increased and decreased LS after nucleos(t)ide analog (NA) regimens.A total of 168 patients with CHB-related compensated cirrhosis were divided into groups according to LS variation post to NA treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000013929DOI Listing
January 2019
8 Reads

Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study.

World J Surg Oncol 2019 Jan 7;17(1). Epub 2019 Jan 7.

Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of Medicine, 79, Gangnam-ro, Jinju, 660-702, South Korea.

Background: While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC.

Methods: Data of 81 patients with histopathologically proven T2 GBC who underwent surgical resection between January 1999 and December 2017 were enrolled from a retrospective database. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1556-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323785PMC
January 2019
7 Reads

Modulation on gallbladder carcinoma by TGF-β1 via IGFBP-2.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430000, China.

Gallbladder carcinoma (GC) occupies more than 90% of all cancers in biliary tract with an increasing incidence. Most patients with GC are already at terminal stage at the time of primary diagnosis, causing unfavorable prognosis and high mortality. Transformation growth factor-beta (TGF-β) is up-regulated in GC. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/CBM-181895DOI Listing
December 2018
7 Reads
1.186 Impact Factor

Neuroendocrine carcinomas of the gallbladder: Lessons learnt from cases at opposite ends of the spectrum.

J BUON 2018 Nov-Dec;23(6):1922-1926

Department of Surgery, Duke University Hospital, Durham, NC, USA.

Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which represents about 0.5% of all gallbladder carcinomas and 0. Read More

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January 2019
1 Read

An autopsy case of primary extranodal NK/T cell lymphoma (extranodal NK/T-cell lymphoma) of the bile duct.

Clin J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology, Tokai University Hachioji Hospital, Tokyo, Japan.

We reported the case of a 50-year-old man diagnosed with extrinsic NK/T-cell lymphoma. He was initially diagnosed with locally advanced unresected pancreatic duct carcinoma and was treated with combination chemotherapy using gemcitabine and nabpaclitaxel. One month after treatment, he developed bleeding. Read More

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http://link.springer.com/10.1007/s12328-018-00931-1
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http://dx.doi.org/10.1007/s12328-018-00931-1DOI Listing
January 2019
10 Reads

Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 25;2018:6124927. Epub 2018 Nov 25.

Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Orthopaedic Department, China-Japan Friendship Hospital, Chaoyang District, Beijing, China.

Background: Previous literatures have investigated the change of miR-20a expression level in the progression of multiple cancers and its influence on patients' survival outcome, but results of now-available evidence are inconsistent.

Objective: To elucidate the prognostic value of circulating and tissue-based miR-20a for patients with various cancers.

Methods: A systematic search and review of eligible publications were carried out in three electronic databases including the Cochrane Library, PubMed, and Embase, and the methodological quality of included studies was assessed according to Newcastle-Ottawa Scale (NOS). Read More

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http://dx.doi.org/10.1155/2018/6124927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286746PMC
November 2018
7 Reads

Mucoepidermoid Carcinoma of the Gallbladder: A Case-Based Study of an Extremely Rare Tumor Highlighting the Role of Immunohistochemical Profiling.

Int J Surg Pathol 2018 Dec 26:1066896918821436. Epub 2018 Dec 26.

1 Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Mucoepidermoid carcinoma (MEC) is rarely reported in the hepatobiliary system. In this article, we detail the first case of MEC arising from the gallbladder, presenting in a 50-year-old male. Imaging and gross examination showed a large mass in the gallbladder fossa infiltrating the liver. Read More

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http://dx.doi.org/10.1177/1066896918821436DOI Listing
December 2018

Staging laparoscopy among three subtypes of extra-hepatic biliary malignancy: a 15-year experience from 10 institutions.

J Surg Oncol 2019 Mar 26;119(3):288-294. Epub 2018 Dec 26.

Department of Surgery, Barnes-Jewish Hospital, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

Background: Staging laparoscopy (SL) is used to avoid resection failure and thus increase the curative resection rate. SL utilization in extra-hepatic biliary tumors (EHBT) is variable.

Methods: Data from 1090 patients with potentially resectable EHBT including gallbladder (GBC), distal (DC), and hilar (HC) subtypes were retrospectively collected from 10 academic centers (2000-2015). Read More

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http://dx.doi.org/10.1002/jso.25323DOI Listing
March 2019
2 Reads

Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study.

J Hepatol 2018 Dec 22. Epub 2018 Dec 22.

Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

Background & Aims: Evidence on the association between physical activity and risk of hepatobiliary cancers is inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).

Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183263
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http://dx.doi.org/10.1016/j.jhep.2018.12.014DOI Listing
December 2018
25 Reads

Modified FOLFIRINOX versus CisGem first-line chemotherapy for locally advanced non resectable or metastatic biliary tract cancer (AMEBICA)-PRODIGE 38: Study protocol for a randomized controlled multicenter phase II/III study.

Dig Liver Dis 2019 Feb 28;51(2):318-320. Epub 2018 Nov 28.

Hôpital privé Jean Mermoz, Lyon, France.

Introduction: Combination of cisplatine and Gemcitabine (CisGem) is the reference 1st line Chemotherapy in patients with advanced biliary cancer. FOLFIRINOX demonstrated an overall survival superiority when compared to gemcitabine in 1st line for patients with metastatic pancreatic adenocarcinoma. Because of similarities between pancreatic and biliary cancers, we proposed a randomized trial comparing mFOLFIRINOX and CisGEm. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.018DOI Listing
February 2019
2 Reads

Progression of immunoglobulin G4-related disease to systematic lupus erythematosus after gastric cancer surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13545

Department of Nephrology, Fujita Health University School of Medicine.

Rationale: Immunoglobulin G4 related disease (IgG4-RD) rarely coexists with other autoimmune diseases, though we had a patient whose primary clinical problem was shifted from IgG4-RD to systemic lupus erythematosus (SLE) after gastrectomy. The present paper aimed to report pathological findings and clinical course of the patient.

Patient Concerns: The patient was a male aged 74 years old with gastric cancer characterized by the following symptoms: Raynaud phenomenon, polyarthralgia, and swollen parotid glands on both sides. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0003
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http://dx.doi.org/10.1097/MD.0000000000013545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320217PMC
December 2018
3 Reads

A Resected Gallbladder Carcinoma Coexisting With Adenomyomatosis Involving Varied Degrees of Intraepithelial Dysplasia: A Case Report and Literature Review.

Surg Laparosc Endosc Percutan Tech 2018 Dec 18. Epub 2018 Dec 18.

Department of Clinical Pathology, Kitasato Institute Hospital, Tokyo, Japan.

A 59-year-old asymptomatic man underwent ultrasonography, which revealed gallstones and thickened gallbladder wall. Abdominal computed tomography (CT) showed a slightly swollen bilocular gallbladder and a soft tissue mass in the fundus site. Segmental adenomyomatosis (ADM) was suspected because numerous fundic cystic lesions were seen on magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000617DOI Listing
December 2018
1 Read

Nomogram to predict overall survival after gallbladder cancer resection in China.

World J Gastroenterol 2018 Dec;24(45):5167-5178

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Aim: To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma (GBC) into a predictive nomogram.

Methods: One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital (PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) in China from January 1, 2003 to January 1, 2018. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i45/5167.htm
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http://dx.doi.org/10.3748/wjg.v24.i45.5167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288645PMC
December 2018
6 Reads

Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma.

Histopathology 2019 Mar 28;74(4):597-607. Epub 2019 Jan 28.

Department of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Aims: Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in gallbladder tissues. In addition, previous evidence has shown that claudin 18 (CLDN18) protein expression is higher in GBC. Read More

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http://doi.wiley.com/10.1111/his.13797
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http://dx.doi.org/10.1111/his.13797DOI Listing
March 2019
6 Reads

Hepatic Sclerosing Hemangioma Simulating Gallbladder Carcinoma: A Rare Case.

J Clin Exp Hepatol 2018 Dec 19;8(4):474-477. Epub 2018 Jul 19.

Icahn School of Medicine at Mount Sinai, Department of Pathology New York, NY, USA 10029-6574.

Sclerosing hemangiomas of the liver are rare benign tumors of the liver. Although hepatic hemangiomas are the most common benign liver tumor, they are mostly cavernous in nature. A hepatic sclerosing hemangioma is defined by presence of fibrosis and hyalinization as a result of degenerative changes in a cavernous hemangioma. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286440PMC
December 2018
1 Read

Laparoscopic narrowband imaging for intraoperative diagnosis of the depth of invasion of gallbladder carcinoma: a preliminary study.

J Hepatobiliary Pancreat Sci 2019 Feb 21;26(2):82-83. Epub 2019 Jan 21.

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-machi, Yufu City, Oita, Japan.

Highlight Iwashita and Inomata present the findings of a preliminary study regarding laparoscopic narrow-band imaging observations of gallbladder carcinoma - a novel intraoperative diagnostic method that can indicate the depth of cancer invasion. They propose that this approach can improve intraoperative diagnostic performance and aid the selection of optimal therapeutic strategies. Read More

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http://dx.doi.org/10.1002/jhbp.603DOI Listing
February 2019

IL-37 suppresses migration and invasion of gallbladder cancer cells through inhibition of HIF-1α induced epithelial-mesenchymal transition.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8179-8185

Basic Medical College, Hubei University of Science and Technology, Xianning P.R. China.

Objective: Gallbladder carcinoma (GBC) is the seventh most common cancer across the globe and the most common malignancy of the biliary tract. Epithelial-mesenchymal transition (EMT) is an important pre-requisite for tumor metastasis; however, its mechanism in GBC has not yet been defined. In the present study, we investigated the effects of interleukin-37 (IL-37) on the epithelial-mesenchymal transition (EMT) of gallbladder cancer cells. Read More

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http://dx.doi.org/10.26355/eurrev_201812_16510DOI Listing
December 2018

Usefulness of noncontrast MRI in differentiation between gallbladder carcinoma and benign conditions manifesting as focal mild wall thickening.

Clin Imaging 2018 Dec 4;54:63-70. Epub 2018 Dec 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Magnetic resonance imaging (MRI) is a reliable imaging tool for evaluating gallbladder carcinoma, but it is costly and time-consuming.

Purpose: To compare noncontrast MRI with multidetector row CT (MDCT) and gadoxetic acid-enhanced whole MRI in distinguishing gallbladder carcinoma from benign disease.

Materials And Methods: 101 patients (36 with gallbladder carcinoma and 65 with benign disease) with mild focal gallbladder wall thickening were included. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.12.001DOI Listing
December 2018
1 Read

Hemorrhage from metastasis of a 5-mm renal cell carcinoma lesion to the gallbladder detected by contrast-enhanced endoscopic ultrasonography.

Dig Liver Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

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http://dx.doi.org/10.1016/j.dld.2018.11.010DOI Listing
November 2018
1 Read

Single-stranded DNA binding protein 2 expression is associated with patient survival in hepatocellular carcinoma.

BMC Cancer 2018 Dec 12;18(1):1244. Epub 2018 Dec 12.

Departments of Surgery, College of Medicine, Hanyang University222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.

Background: SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic malignancies, prostate cancer, esophageal squamous cell carcinoma, ovarian cancer, and gallbladder cancer. However, an oncogenic role of SSBP2 has been suggested in glioblastoma patients. Read More

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http://dx.doi.org/10.1186/s12885-018-5158-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291933PMC
December 2018
1 Read

Occult Gallbladder Carcinoma Presenting as a Primary Ovarian Tumour: a Case Report and Review of Literature.

Indian J Surg Oncol 2018 Dec 20;9(4):618-621. Epub 2018 Jul 20.

1Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, 575018 India.

The ovary is a common site of metastasis from various organs. However, little is known about gallbladder carcinoma metastasising to the ovaries and presenting as a primary ovarian tumour. We report a case of a metastatic gallbladder carcinoma which mimicked a primary ovarian tumour in a 31-year-old woman who presented with menstrual symptoms and an ovarian mass without obvious signs and symptoms related to gallbladder carcinoma. Read More

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http://dx.doi.org/10.1007/s13193-018-0786-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265202PMC
December 2018
1 Read

Neoplastic Meningitis: A Study from a Tertiary Care Hospital from Coastal India.

J Cytol 2018 Oct-Dec;35(4):255-259

Department of Cellular Pathology, Leighton Hospital, Crewe, Cheshire, United Kingdom.

Introduction: Neoplastic involvement of cerebrospinal fluid (CSF) secondary to known or unknown primaries elsewhere is a poor prognostic factor and is equivalent to stage IV disease.

Aim: The aim of the study is to analyse the cytological features of neoplastic meningitis in a tertiary care center.

Materials And Methods: A retrospective study of 400 consecutive CSF samples was done in the cytology laboratory of our hospital. Read More

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http://www.jcytol.org/preprintarticle.asp?id=239969
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http://dx.doi.org/10.4103/JOC.JOC_167_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210820PMC
December 2018
8 Reads

EBV as a potential risk factor for hepatobiliary system cancer: A meta-analysis with 918 cases.

Pathol Res Pract 2019 Feb 2;215(2):278-285. Epub 2018 Nov 2.

Department of General Surgery, The Second Affiliated Hospital of Guangxi Medical University, NO.166. DaxueXi Rd, Nanning, Guangxi Zhuang Autonomous Region, 530021, PR China. Electronic address:

Objectives: Hepatobiliary system cancer, which includes hepatocellular carcinoma (HCC), cholangiocarcinoma, and gallbladder carcinoma, has an increase of incidence and mortality due to various risk factors. Epstein-Barr virus (EBV) is associated with various types of lymphomas and carcinomas, which is also acknowledged as the first-discovered human tumor virus. Despite this, there is no systematic analysis about the relationship between the infection of EBV and hepatobiliary system cancer. Read More

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http://dx.doi.org/10.1016/j.prp.2018.10.037DOI Listing
February 2019
3 Reads

MiR-1-5p is down-regulated in gallbladder carcinoma and suppresses cell proliferation, migration and invasion by targeting Notch2.

Pathol Res Pract 2019 Jan 22;215(1):200-208. Epub 2018 Oct 22.

Emergency Trauma Surgery, BinZhou Medical University Hospital, Binzhou, Shandong, 256600, China. Electronic address:

Background: Numerous studies have demonstrated that aberrant microRNAs (miRNAs) are involved in tumorigenesis and tumor progression. Nevertheless, the precise role of miR-1-5p in gallbladder carcinoma cell growth and metastasis remains not fully revealed.

Material And Methods: The levels of miR-1-5p were detected in gallbladder carcinoma tissues and cell lines using qRT-PCR method. Read More

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http://dx.doi.org/10.1016/j.prp.2018.10.013DOI Listing
January 2019
10 Reads

A case report: Feasibility of a near infrared ray vision system (Photo dynamic eye®) for the postoperative ischemic complication of gallbladder carcinoma.

Int J Surg Case Rep 2018 13;53:312-315. Epub 2018 Nov 13.

Japan Seafares Relief Association Moji Ekisaikai Hospital, Japan.

Introduction: Radical resection with or without preserving extra-hepatic bile duct has shown similar prognoses for gallbladder carcinoma (GB ca), although aggressive resection is essential. In preserving bile duct, ischemic complications are serious, life-threatening serious problems. Correct evaluation of the blood flow to the biliary tract is crucial. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251061PMC
November 2018
11 Reads

Elective cholecystectomy as a rare presentation of metastatic breast cancer.

J Surg Case Rep 2018 Nov 13;2018(11):rjy301. Epub 2018 Nov 13.

Surgical Department, Centro Hospitalar Entre Douro e Vouga, E.P.E., Santa Maria da Feira, Portugal.

Cholecystectomy leads, occasionally, to the diagnosis of subclinical primary carcinomas and rarely metastatic tumors. The authors report the diagnosis of gallbladder metastasis after an elective cholecystectomy for symptomatic cholelithiasis. Histological examination disclosed a metastasis from a lobular breast carcinoma. Read More

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http://dx.doi.org/10.1093/jscr/rjy301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234511PMC
November 2018
13 Reads

Use of retrieval bag in the prevention of wound infection in elective laparoscopic cholecystectomy: is it evidence-based? A meta-analysis.

BMC Surg 2018 Nov 19;18(1):102. Epub 2018 Nov 19.

Department of Surgery, Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland.

Background: Surgical site infections complicate elective laparoscopic cholecystectomies in 2,4-3,2% of cases. During the operation the gallbladder is commonly extracted with a retrieval bag. We conducted a meta-analysis to clarify whether its use plays a role in preventing infections. Read More

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http://dx.doi.org/10.1186/s12893-018-0442-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245513PMC
November 2018
3 Reads

Obesity and cancer risk: Emerging biological mechanisms and perspectives.

Metabolism 2019 Mar 13;92:121-135. Epub 2018 Nov 13.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece. Electronic address:

Continuously rising trends in obesity-related malignancies render this disease spectrum a public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as population attributable fraction, is 11.9% in men and 13. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183023
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http://dx.doi.org/10.1016/j.metabol.2018.11.001DOI Listing
March 2019
30 Reads

Frozen section examination of pancreas, gallbladder, extrahepatic biliary tree, liver, and gastrointestinal tract.

Cesk Patol 2018 ;54(2):63-71

The main indications for intraoperative consultation of gastrointestinal tract, liver, and pancreatobiliary system are to evaluate the resection margin and to make a tissue diagnosis of lesions for which preoperative histology is not aviable for various reasons. Special situations include the evaluation of liver donor biopsies for the presence of steatosis and inflamation, or determination that ganglion cells are present in the bowel wall at the level where the anastomosis will be placed in case of Hirschprung's disease. The most worrisome pitfalls include differentiating pancreatic ductal carcinoma from chronic pancreatitis, distinguishing biliary tree and gallbladder carcinoma from reactive changes caused by inflammation, and recognizing the presence of diffuse adenocarcinoma at the resection margin of the esophagus and stomach. Read More

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January 2018
9 Reads

[Radiologic diagnosis of the gallbladder and bile ducts - part 2 : Acute and chronic cholecystitis, primary sclerosing cholangitis (PSC), benign and malignant masses of the biliary system].

Radiologe 2018 Dec;58(12):1099-1114

Kinderradiologie im Dr. von Haunerschen Kinderspital der Radiologischen Klinik und Poliklinik, Ludwig-Maximilian-Universität München, München, Deutschland.

Upper abdominal pain, icterus and cholestasis are the symptoms leading to evaluation of the biliary tract. Together with its complications biliary stone disease is the main reason for inflammation of the biliary system. A distinction is made between acute and chronic variants. Read More

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http://dx.doi.org/10.1007/s00117-018-0463-8DOI Listing
December 2018
3 Reads

Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 9;1865(2):308-321. Epub 2018 Nov 9.

Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Austria; Center for Biomarker Research in Medicine, Graz, Austria; Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Germany. Electronic address:

Biliary tract cancer (BTC) represents a malignant tumor of the biliary tract including cholangiocarcinoma (CCA) and the carcinoma of the gallbladder (GBC) with a 5-year survival rate between 5 and 18% due to late diagnosis and rapid disease progression. Chronic inflammation is one of the main risk factors for CCA and GBC in particular. IL-6, as a mediator of inflammation, can act through a membrane-bound receptor alpha-chain (mIL-6R, "IL-6 classic signaling") or via soluble forms (sIL-6R, "IL-6 trans-signaling"). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183045
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http://dx.doi.org/10.1016/j.bbadis.2018.11.006DOI Listing
February 2019
10 Reads