7,087 results match your criteria Gallbladder Carcinoma


Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation.

Liver Int 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Background: Biliary cancer, comprising cholangio- and gallbladder carcinomas, is associated with high mortality due to asymptomatic disease onset and resulting late diagnosis. Currently, no robust diagnostic biomarker is clinically available. Therefore, we explored the feasibility of extracellular vesicles (EVs) as a liquid biopsy tool for biliary cancer screening and hepatobiliary cancer differentiation. Read More

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http://dx.doi.org/10.1111/liv.14585DOI Listing

Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma.

Cancer Manag Res 2020 12;12:4475-4482. Epub 2020 Jun 12.

Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.

Purpose: This study aimed to evaluate the efficiency of several parameters, including the neutrophil-to-lymphocyte ratio (NLR) obtained from preoperative routine blood examination, either alone or as an adjunct to the carbohydrate antigen 19-9 (CA19-9), for the diagnosis of gallbladder carcinoma (GBC).

Patients And Methods: Data from 123 patients with gallbladder cholesterol polyps (GCP), 80 with gallbladder adenoma (GA), and 103 with GBC were reviewed retrospectively. Receiver operating characteristic analysis was used to assess the sensitivity, specificity, and clinical value of the NLR, CA19-9, and their combination. Read More

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http://dx.doi.org/10.2147/CMAR.S255480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297325PMC

Preoperative C-Reactive Protein/Albumin Ratio as a Predictive Factor for Gallbladder Carcinoma.

In Vivo 2020 Jul-Aug;34(4):1901-1908

Department of Surgery, National Hospital Organization, Iwakuni Clinical Center, Yamaguchi, Japan.

Background/aim: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection.

Patients And Methods: Fifty-three patients who underwent surgical resection for GBC between January 2008 and September 2019 were enrolled. Read More

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http://dx.doi.org/10.21873/invivo.11986DOI Listing

Sarcomatoid carcinoma of the gallbladder: a case report.

J Int Med Res 2020 Jun;48(6):300060520935283

Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.

Sarcomatoid carcinoma is a rare type of gallbladder cancer with no specific clinical manifestation. The final diagnosis depends on pathological and immunohistochemical examination. Sarcomatoid carcinoma is characterized by early lymphatic metastasis, rapid progression, a high short-term recurrence rate, and a worse prognosis than adenocarcinoma. Read More

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http://dx.doi.org/10.1177/0300060520935283DOI Listing

[Gallbladder Perforation after Transarterial Chemoembolization in a Patient with a Huge Hepatocellular Carcinoma].

Korean J Gastroenterol 2020 Jun;75(6):351-355

Departments of Radiology, Kosin University College of Medicine, Busan, Korea.

Transarterial chemoembolization (TACE) is a common treatment for unresectable hepatocellular carcinoma (HCC). The most common complications after TACE are non-specific symptoms called post-embolization syndrome, such as abdominal pain or fever. Rare complications, such as liver failure, liver abscess, sepsis, pulmonary embolism, cholecystitis, can also occur. Read More

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http://dx.doi.org/10.4166/kjg.2020.75.6.351DOI Listing

Clinicopathological Characteristics and Surgical Outcomes of Primary Cystic Duct Carcinoma: A Multi-institutional Study.

World J Surg 2020 Jun 23. Epub 2020 Jun 23.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

Background: The role of surgery in the management of primary cystic duct carcinoma (CDC) remains unclear especially in advanced disease. This study aimed to evaluate long-term outcomes in patients undergoing surgery for primary CDC.

Methods: From a multi-institutional database, we identified 41 patients who underwent surgery for primary CDC, defined as a part of gallbladder carcinoma with the tumor centre located in the cystic duct. Read More

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http://dx.doi.org/10.1007/s00268-020-05656-2DOI Listing

The Functional Role of Long Non-coding RNA UCA1 in Human Multiple Cancers: a Review Study.

Curr Mol Med 2020 Jun 19. Epub 2020 Jun 19.

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan. Iran.

In various cancers, high-grade tumor and poor survival rate in patients with upregulated lncRNAs UCA1 have been confirmed. Urothelial carcinoma associated 1 (UCA1) is an oncogenic non-coding RNA with a length of more than 200 nucleotides. The UCA1 regulate critical biological processes that are involved in cancer progression, including cancer cell growth, invasion, migration, metastasis, and angiogenesis. Read More

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http://dx.doi.org/10.2174/1566524020666200619124543DOI Listing

Xanthogranulomatous Cholecystitis: Is Surgery Difficult? Is Laparoscopic Surgery Recommended?

J Laparoendosc Adv Surg Tech A 2020 Jun 22. Epub 2020 Jun 22.

Department of General Surgery, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Xanthogranulomatous cholecystitis (XGC) is a rare inflammatory disease of the gallbladder (GB). XGC surgery is a difficult process due to its clinical, radiological, and intraoperative findings. In this study, our aim is to show the difficulties of XGC surgery and to find out if laparoscopic surgery is a sufficient procedure. Read More

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http://dx.doi.org/10.1089/lap.2020.0334DOI Listing

Tuberculosis of the gallbladder-another one of its many faces.

Indian J Tuberc 2020 Apr 24;67(2):257-259. Epub 2019 Aug 24.

Department of Radiodiagnosis and Modern Imaging, SMS Medical College, Jaipur, Rajasthan, India.

Abdominal tuberculosis is not uncommon in developing countries which usually presents as involvement of ileo-caecal junction. Involvement of gall bladder by tuberculosis is rare and thus, imaging diagnosis is unlikely. The diagnosis is confirmed only on histopathology. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.08.011DOI Listing

Relationship between clinical and histopathological features of patients undergoing cholecystectomy.

Prz Gastroenterol 2020 22;15(2):131-137. Epub 2019 Jul 22.

Department of Pathology, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey.

Introduction: Cholelithiasis is most common disease of the gallbladder and cholecystectomy is the one of the most performed surgical procedure worldwide.

Aim: To assess the relationship between the demographic, biochemical, and histopathological variables of patients who underwent cholecystectomy.

Material And Methods: Demographic, biochemical, and histopathological data of 5077 patients undergoing cholecystectomy were compared in terms of two different aspects: open cholecystectomy (OC group; = 2090) versus laparoscopic cholecystectomy (LC group; = 2987), and an elective group ( = 4814) versus an emergency group ( = 263). Read More

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http://dx.doi.org/10.5114/pg.2019.86772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294973PMC

RNA Sequencing Revealed Signals of Evolution From Gallbladder Stone to Gallbladder Carcinoma.

Front Oncol 2020 29;10:823. Epub 2020 May 29.

Department of Biliary Tract Surgery I, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.

Gallbladder stone is a major risk factor for gallbladder carcinoma (GBC), while there is still a controversy whether period of follow-up since newly diagnoses of asymptomatic gallstones increases the risk of GBC. In this study, 10 GBC patients and 30 patients with gallstones were admitted to our hospital. Patients with gallstones were divided into 3 groups according to the follow-up time, involving 10 patients with follow-up period of 1-3 years (GS3 group), 10 patients with follow-up period of 5-10 years (GS5 group), and 10 patients with follow-up period of more than 10 years (GS10 group). Read More

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http://dx.doi.org/10.3389/fonc.2020.00823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272658PMC

[Systemic Chemotherapy of gallbladder carcinoma - simply the same as for cholangiocarcinoma?]

Z Gastroenterol 2020 Jun 16;58(6):583-589. Epub 2020 Jun 16.

Recently published genomic data revealed substantial differences of gallbladder and extrahepatic as well as intrahepatic cholangiocarcinoma. However, these data have no influence on the choice of systemic therapy to date. This review shall provide a concise overview of epidemiology and pathogenesis of gallbladder carcinoma as well as the differences in the mutational profile in comparison to cholangiocarcinoma. Read More

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http://dx.doi.org/10.1055/a-1161-3985DOI Listing

Chronic gallbladder wall thickening: Is it always malignancy?

SA J Radiol 2020 18;24(1):1844. Epub 2020 May 18.

Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Gallbladder wall thickening, associated with features like perforation, fistula formation and invasion of adjacent organs, is often assumed to be malignant. Xanthogranulomatous cholecystitis (XGC) causes gallbladder wall thickening with similar aggressive features and closely mimics gallbladder carcinoma clinically, radiologically and surgically. Differentiating between these two is crucial for management as misdiagnosis of gallbladder cancer can lead to unnecessary radical surgery. Read More

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http://dx.doi.org/10.4102/sajr.v24i1.1844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276480PMC

Mixed adenoneuroendocrine carcinoma of the gallbladder, amphicrine type: Case report and review of literature.

Pathol Res Pract 2020 Jul 4;216(7):152997. Epub 2020 May 4.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

Amphicrine type mixed adenoneuroendocrine carcinoma (MANEC), also known as amphicrine carcinoma, is an exceedingly rare neoplasm comprising of tumor cells simultaneously demonstrating both neuroendocrine and exocrine differentiation. Majority of reported cases were found in tubular gastrointestinal tracts such as colon. Herein, we report the first case of amphicrine carcinoma in gallbladder in a 57-year-old female who presented with abdominal pain, vomiting, and gallbladder mass on imaging followed by radical cholecystectomy. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152997DOI Listing

Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma.

Signal Transduct Target Ther 2020 Jun 12;5(1):77. Epub 2020 Jun 12.

Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.

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http://dx.doi.org/10.1038/s41392-020-0162-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289871PMC

Is cytoreductive surgery and hyperthermic intraperitoneal chemotherapy indicated in hepatobiliary malignancies?

World J Surg Oncol 2020 Jun 11;18(1):124. Epub 2020 Jun 11.

Division of Surgical Oncology, Icahn School of Medicine at Mount Sinai St. Luke's West Hospital, 425 West 59th Street, Suite 7B, New York, NY, 10019, USA.

Background: Hepatopancreaticobiliary malignancies with peritoneal carcinomatosis exhibit poor survival with current therapies: hepatocellular carcinoma 11 months with sorafenib, and pancreaticobiliary 9-14 months with systemic chemotherapy. However, limited data exist on the utility of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in these patients.

Methods: We retrospectively reviewed our institutional hepatopancreaticobiliary malignancies with peritoneal carcinomatosis which underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy from 2007 to 2017 and analyzed perioperative and oncologic outcomes. Read More

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http://dx.doi.org/10.1186/s12957-020-01898-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291534PMC

A metagenomic study of biliary microbiome change along the cholecystitis-carcinoma sequence.

Clin Transl Med 2020 Jun 11. Epub 2020 Jun 11.

Department of General Surgery and Laboratory of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Gallbladder cancer (GBC) is the most common cancer type of the biliary tract, and an association has been found between chronic calculous cholecystitis (CCC) and an increased incidence of GBC mortality. An understanding of the relationship between CCC and its carcinogenesis may enable us to prevent and cure GBC. In this study, we attempted to explore changes in the microbiome profile that take place during the transition from chronic cholecystitis mucosa to malignant lesions. Read More

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http://dx.doi.org/10.1002/ctm2.97DOI Listing

A Comparative Analysis of Clinical Characteristics and Histomorphologic and Immunohistochemical Spectrum of Gallbladder Carcinoma in Young Adults (< 45 Years) and Elderly Adults (> 60 Years).

Indian J Surg Oncol 2020 Jun 6;11(2):297-305. Epub 2020 Feb 6.

Department of Pathology, Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal, India.

Gallbladder carcinoma (GBC) is more frequent after 60 years of age; its behavior in young adults has not been much studied. A retrospective analysis was performed in patients who underwent a cholecystectomy procedure between the years 2001 to 2016. A group of young patients (< 45) were compared with elderly patients (> 60 years) with reference to various clinical, histomorphologic, and immunohistochemical parameters. Read More

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http://dx.doi.org/10.1007/s13193-020-01044-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260299PMC

Computer-aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma.

J Cell Mol Med 2020 Jun 8. Epub 2020 Jun 8.

National-Local Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diesases, Department of Biochemistry, Dalian Medical University, Dalian, China.

Gallbladder carcinoma (GBC) is a vicious and invasive disease. The major challenge in the clinical treatment of GBC is the lack of a suitable prognosis method. Chemokine receptors such as CXCR3, CXCR4 and CXCR7 play vital roles in the process of tumour progression and metastasis. Read More

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http://dx.doi.org/10.1111/jcmm.15219DOI Listing

Gallbladder squamous cell carcinoma: An analysis of 1084 cases from the National Cancer Database.

J Surg Oncol 2020 Jun 8. Epub 2020 Jun 8.

Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Background/objectives: Gallbladder squamous cell carcinoma (SCC) is an uncommon malignancy whose rarity has made it particularly challenging to study. We utilized a national database to shed light on the clinicopathologic characteristics, management patterns, and survival associated with these tumors.

Methods: Patients with gallbladder SCC were identified in the National Cancer Database. Read More

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http://dx.doi.org/10.1002/jso.26066DOI Listing

Gallbladder Tuberculosis Mimicking Gallbladder Carcinoma: A Case Report and Review of the Literature.

Cureus 2020 May 4;12(5):e7950. Epub 2020 May 4.

Surgical Oncology, Mohammed VI University Hospital, Regional Oncology Center, Oujda, MAR.

Gallbladder tuberculosis (GT) is an extremely rare disease entity, even in our country Morocco known for being an endemic area. The lack of pathognomonic clinical presentation and radiological features of GT makes preoperative diagnosis unlikely and poses a diagnostic dilemma regarding gallbladder carcinoma (GC). The diagnosis is usually made by histological examination after cholecystectomy, highlighting the importance of sending every gallbladder specimen to pathology. Read More

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http://dx.doi.org/10.7759/cureus.7950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271036PMC

Duplication of extrahepatic bile duct with lower common bile duct cancer.

J Hepatobiliary Pancreat Sci 2020 Jun 7. Epub 2020 Jun 7.

Department of Internal Medicine, Izumo-city General Medical Center, Izumo, Japan.

A 90-year-old female who previously underwent a cholecystectomy for a gallbladder stone was admitted to our hospital with jaundice. Magnetic resonance cholangiopancreatography (MRCP) revealed left and right bile ducts parallel with the duodenal papilla, and joined distally to form a single short common bile duct with no pancreaticobiliary maljunction (Figure 1). The remnant cystic duct diverged from the right hepatic duct without a common hepatic duct. Read More

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http://dx.doi.org/10.1002/jhbp.779DOI Listing

Diagnostic role of fine needle aspiration cytology (FNAC) in the evaluation of gall bladder lesions: an institutional experience.

Diagn Cytopathol 2020 Jun 7. Epub 2020 Jun 7.

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Background: Carcinoma of the gall bladder is the most common malignancy of the biliary tract. Ultrasonography guided Fine Needle Aspiration Cytology (FNAC) plays a crucial role in early detection of gall bladder (GB) lesions. Early diagnosis of GB lesions is a necessity in view of rising trend in GB carcinoma related mortality in India. Read More

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http://dx.doi.org/10.1002/dc.24517DOI Listing

MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth.

Exp Cell Res 2020 Jun 2:112118. Epub 2020 Jun 2.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Biliary Tract Disease Center of Zhongshan Hospital, Fudan University, Shanghai, China; Biliary Tract Disease Institute, Fudan University, Shanghai, China. Electronic address:

The MUC16 C-terminal (MUC16c) level is associated with tumor serum CA-125 levels, however, the roles remain unclear in gallbladder carcinoma (GBC). In this study, we found that MUC16c promoted glucose uptake and glycolysis for GBC cell proliferation. Mass spectrometry analysis suggested that MUC16c could combine with aldolase. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112118DOI Listing

Circular RNA HIPK3: A Key Circular RNA in a Variety of Human Cancers.

Front Oncol 2020 15;10:773. Epub 2020 May 15.

Hepatic Surgery Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

Circular RNAs (circRNAs), which act as initiators and promoters of various diseases, were thought to be mostly noncoding RNAs (ncRNAs) in eukaryotes, until recent studies confirmed that some circRNAs have the function of encoding proteins. Accumulating research findings have proved that dysregulation of circRNAs is associated with the developmental process of multiple cancers. circHIPK3, an example of circRNA, is frequently expressed in many diseases, such as diabetes, age-related cataract, idiopathic pulmonary fibrosis, preeclampsia, osteoblasts, and retinal vascular dysfunction, leading to disease development and progression. Read More

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http://dx.doi.org/10.3389/fonc.2020.00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242753PMC

Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard.

Pak J Med Sci 2020 May-Jun;36(4):652-656

Syed Omair Adil, Lecturer, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan.

Objective: To evaluate the diagnostic accuracy of ultrasound in obstructive jaundice taking MRCP as gold standard.

Methods: This cross-sectional study was conducted at Dow Institute of Radiology (DIR), Dow University of Health Sciences (DUHS), Karachi from 2 May 2018 till 2 November 2018. Both male and female patients aged 30 to 80 years with suspected obstructive jaundice were included. Read More

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http://dx.doi.org/10.12669/pjms.36.4.1665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260912PMC

Prognostic Significance of the Preoperative Lymphocyte to Monocyte Ratio in Patients with Gallbladder Carcinoma.

Cancer Manag Res 2020 11;12:3271-3283. Epub 2020 May 11.

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, People's Republic of China.

Background: This study was designed to investigate the prognostic value of the lymphocyte to monocyte ratio (LMR) in patients with gallbladder carcinoma (GBC).

Patients And Methods: We retrospectively enrolled 154 consecutive GBC patients from 2005 to 2017 in this study. The LMR of preoperative blood samples was calculated by dividing the lymphocyte count by the monocyte count. Read More

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http://dx.doi.org/10.2147/CMAR.S243326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227785PMC

A retrospective study of patient-tailored FOLFIRINOX as a first-line chemotherapy for patients with advanced biliary tract cancer.

BMC Cancer 2020 Jun 3;20(1):515. Epub 2020 Jun 3.

INSERM U935 Campus CNRS, Villejuif, France.

Background: FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic cancer have been treated similarly with gemcitabine alone or combined with a platinum compound. With growing evidence supporting the role of fluoropyrimidines in the treatment of BTC, we aimed at assessing the outcomes of patients (pts) with BTC on frontline FOLFIRINOX. Read More

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http://dx.doi.org/10.1186/s12885-020-07004-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268699PMC

Targeted-gene sequencing of an undifferentiated gallbladder carcinoma: a case report.

Diagn Pathol 2020 Jun 2;15(1):66. Epub 2020 Jun 2.

Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, PR China.

Background: Undifferentiated carcinomas of the gallbladder are extremely rare. Most undifferentiated carcinomas are accompanied by adjacent foci of other conventional carcinomas, and a transition zone is shared between them. However, genetic alterations of undifferentiated gallbladder carcinoma and the similarities or differences between the undifferentiated carcinoma and the foci conventional carcinoma are unknown. Read More

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http://dx.doi.org/10.1186/s13000-020-00981-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268304PMC

The Landmark Series: Gallbladder Cancer.

Ann Surg Oncol 2020 May 30. Epub 2020 May 30.

Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Given the rarity of gallbladder carcinoma, level I evidence to guide the multimodal treatment of this disease is lacking. Since 2010, four randomized phase III clinical trials including ABC-02, PRODIGE-12/ACCORD-18, BILCAP, and BCAT, and a single-arm phase II trial (SWOG0809) have been reported on the use of adjuvant strategies for biliary malignancies. These trials have led to the recommendation that patients with resected biliary tract cancer should be offered adjuvant capecitabine chemotherapy and those with R1 margins could be considered for chemoradiotherapy. Read More

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http://dx.doi.org/10.1245/s10434-020-08654-9DOI Listing

Regorafenib after failure of gemcitabine and platinum-based chemotherapy for locally advanced/metastatic biliary tumors: a randomized, double-blind, phase 2 trial - REACHIN.

Ann Oncol 2020 May 25. Epub 2020 May 25.

GE and Digestive Oncology Department, CUB Hôpital Erasme, Brussels, Belgium.

Background: There is a high unmet clinical need for treatments for advanced/metastatic biliary tract cancers (BTC) after progression on first-line chemotherapy. Regorafenib has demonstrated efficacy in some gastrointestinal tumors that progress on standard therapies.

Patients And Methods: REACHIN was a multicenter, double-blind, placebo-controlled, randomized phase 2 study designed to evaluate the safety and efficacy of regorafenib in patients with nonresectable/metastatic BTC that progressed after gemcitabine/platinum chemotherapy. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.05.018DOI Listing

Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.

Diagn Pathol 2020 May 27;15(1):63. Epub 2020 May 27.

Department of Pathology, Jeonbuk National University Medical School, 567 Baekje-daero, Dukjin-gu, Jeonju, 54896, Republic of Korea.

Background: Recently, FAM83H was reported to have roles in cancer progression in conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from the public database indicates a molecular relationship between FAM83H and zinc finger proteins, especially between FAM83H and ZNF16. However, studies on FAM83H and ZNF16 in gallbladder cancer have been limited. Read More

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http://dx.doi.org/10.1186/s13000-020-00985-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254718PMC

A rare case of primary adenosquamous carcinoma of the liver with gallbladder metastasis.

Kaohsiung J Med Sci 2020 May 24. Epub 2020 May 24.

Department of Surgery, Kaohsiung Medical University Hospital, Taiwan.

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http://dx.doi.org/10.1002/kjm2.12227DOI Listing

Effects of Primary Sclerosing Cholangitis on Risks of Cancer and Death in People With Inflammatory Bowel Diseases, Based on Sex, Race, and Age.

Gastroenterology 2020 May 20. Epub 2020 May 20.

NIHR Birmingham Biomedical Research Centre, Centre for Liver and Gastroenterology Research, University of Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, UK; Toronto Centre for Liver Disease, University Health Network and Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Background & Aims: There are insufficient population-level data on effects of primary sclerosing cholangitis (PSC) in patients with inflammatory bowel disease (IBD).

Methods: We identified incident cases of IBD, with PSC (PSC-IBD) and without, from April 2006 through to April 2016 and collected data on outcomes through April 2019. We linked data from national healthcare registries maintained for all adults in England on hospital attendances, imaging and endoscopic evaluations, surgical procedures, cancer, and deaths. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.05.049DOI Listing

Oncologic safety of laparoscopic radical cholecystectomy in pT2 gallbladder cancer: A propensity score matching analysis compared to open approach.

Medicine (Baltimore) 2020 May;99(20):e20039

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine.

The role of laparoscopic radical cholecystectomy (LRC) in the surgical management of T2 gallbladder carcinoma (GBC) is still controversial.The medical records of patients with T2 GBC treated with radical cholecystectomy were retrospectively reviewed. In this study, we compare the short- and long-term oncologic outcomes, using propensity score matching analysis, of patients with T2 GBC who underwent LRC and open radical cholecystectomy (ORC). Read More

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http://dx.doi.org/10.1097/MD.0000000000020039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253605PMC

Surgical Treatments of Hepatobiliary Cancers.

Hepatology 2020 May 21. Epub 2020 May 21.

Gustave L. Levy Place, New York, USA.

Hepatobiliary cancers which include Hepatocellular carcinoma (HCC) and biliary tract cancers (Cholangiocarcinoma (CCA) and Gallbladder carcinoma (GBC)) are associated with significant morbidity and mortality based on the stage of the disease at presentation. With improved screening for hepatobiliary malignancies in patients with risk factors and with widespread use of laparoscopic cholecystectomy, hepatobiliary malignancies including incidental diagnosis of GBC is on the rise. Definitive treatment of hepatobiliary malignancies include surgical resection, ablation, and liver transplantation. Read More

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http://dx.doi.org/10.1002/hep.31325DOI Listing

TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis.

Eur Rev Med Pharmacol Sci 2020 May;24(9):4745-4755

Department of Critical Care Medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, P.R. China.

Objective: Ferroptosis is a recently identified form of controlled cell death generally associated with the accumulation of lipid-associated reactive oxygen species (ROS). However, the molecular mechanisms underlying ferroptosis have not been established.

Materials And Methods: Microarray expression data for three human gallbladder carcinoma (GBC) and matched non-tumour specimens were downloaded from the Gene Expression Omnibus (GEO) repository. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21163DOI Listing

Laparoscopic Anatomical Portal Territory Hepatectomy with Cirrhosis by Takasaki's Approach and Indocyanine Green Fluorescence Navigation (with Video).

Ann Surg Oncol 2020 May 19. Epub 2020 May 19.

Department of General Surgery, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.

Background: Anatomical liver resection has shown advantages in the treatment of hepatocellular carcinoma (HCC).1 Pure laparoscopic hepatectomy for some deep lesions remains challenging, especially for anatomical resection.2 Because of many kinds of hepatic venous variations, resection along the hepatic vein may not be a "real" anatomical resection. Read More

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http://dx.doi.org/10.1245/s10434-020-08592-6DOI Listing
May 2020
3.930 Impact Factor

Laparoscopy Versus Open Reoperation for Incidental Gallbladder Carcinoma After Laparoscopic Cholecystectomy.

J Laparoendosc Adv Surg Tech A 2020 May 19. Epub 2020 May 19.

Department of General Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Some reports assert that there is a risk that laparoscopy might worsen the prognosis of incidental gallbladder carcinoma (IGBC) after laparoscopic cholecystectomy (LC) compared with open reoperation. The purpose of this study was to evaluate whether the surgical approach influences outcomes in patients with IGBC after LC. We retrospectively reviewed the medical records of 106 patients diagnosed with IGBC who had undergone LC for benign gallbladder disease such as cholecystolithiasis at our hospital between April 2010 and February 2018. Read More

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http://dx.doi.org/10.1089/lap.2019.0802DOI Listing

Incidental Carcinoma after Cholecystectomy for Benign Disease of the Gallbladder: A Meta-Analysis.

J Clin Med 2020 May 14;9(5). Epub 2020 May 14.

Department of Internal Medicine, Nowon Eulji University Hospital, Eulji University School of Medicine, Seoul 01830, Korea.

This study aimed to determine the incidence and the prognosis of incidental carcinoma of the gallbladder (IGBC) after cholecystectomy through a meta-analysis. This meta-analysis included 51 studies and 436,636 patients with cholecystectomy. The incidence rate of IGBC after cholecystectomy was 0. Read More

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http://dx.doi.org/10.3390/jcm9051484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290945PMC

Vascular Resection During Hepatectomy for Liver Malignancies. Results from a Tertiary Center using Autologous Peritoneal Patch for Venous Reconstruction.

World J Surg 2020 May 16. Epub 2020 May 16.

Department of General and Oncological Surgery, Ospedale Mauriziano "Umberto I" Hospital, Largo Turati, 62, 10128, Turin, Italy.

Background: To evaluate early outcomes of venous reconstruction with peritoneal patch (PP) during resection for hepatic malignancies.

Methods: Since May 2015, PP was considered as the first option for venous reconstruction in the case of lateral resection. Between May 2015 and June 2019, 579 consecutive hepatectomies for malignancies were performed at our institution. Read More

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http://dx.doi.org/10.1007/s00268-020-05564-5DOI Listing

Identification of microRNAs associated with the survival of patients with gallbladder carcinoma.

J Int Med Res 2020 May;48(5):300060520918061

Department of Prenatal Diagnostic, Jiaxing Maternity and Children Health Care Hospital, Jiaxing University, Jiaxing, Zhejiang, China.

Objective: This study investigated micro (mi)RNAs associated with the survival of patients with gallbladder carcinoma (GBC).

Methods: miRNA expression profiling was carried out of 40 cancerous tissues from GBC patients with long-term (n = 20) and short-term (n = 20) survival and eight healthy gallbladder tissues from the Gene Expression Omnibus database. miRNAs dysregulated in GBC patients with long-term or short-term survival were identified using GEO2R and VennDiagram packages, and analyzed by miRNA target prediction tools and the clusterProfiler package. Read More

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http://dx.doi.org/10.1177/0300060520918061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238852PMC

Percutaneous Intraductal Microwave Ablation of Malignant Biliary Strictures: Initial Experience.

AJR Am J Roentgenol 2020 May 14:1-7. Epub 2020 May 14.

Department of Radiology, Okan University Hospital, Aydınlı Cad 2, İstanbul, Tuzla 34947, Turkey.

Metallic stenting of malignant biliary strictures is the preferred method of palliation, because most patients present when the condition is inoperable. Most metallic stents, however, are occluded 6-8 months after deployment. Intraductal radiofrequency ablation has been used in previous studies to improve stent patency. Read More

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http://dx.doi.org/10.2214/AJR.19.21897DOI Listing

Deciphering the Roles of IFITM1 in Tumors.

Mol Diagn Ther 2020 May 11. Epub 2020 May 11.

Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, P.R. China.

Interferon (IFN)-induced transmembrane protein 1 (IFITM1), a member of the IFN-induced transmembrane protein family, is reported to be highly expressed in tumor tissues as well as cancer cell lines, and it is an independent prognostic biomarker for patients with certain tumor types, such as gallbladder carcinoma, esophageal adenocarcinoma, colorectal cancer, and gastric cancer. Moreover, overexpression of IFITM1 promotes tumor cell proliferation, invasion, metastasis, angiogenesis, and therapeutic resistance, including endocrine therapy, chemotherapy, and radiotherapy resistance. Due to these diverse functions of IFITM1 in tumors, targeting IFITM1 may provide a novel strategy for cancer treatment and be highly desirable to improve cancer patient outcomes. Read More

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http://dx.doi.org/10.1007/s40291-020-00469-4DOI Listing

A Rare Case of Gallbladder Small Cell Carcinoma.

J Gastrointest Surg 2020 May 11. Epub 2020 May 11.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11605-020-04620-8DOI Listing

Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base.

J Surg Oncol 2020 May 7. Epub 2020 May 7.

Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Background And Objectives: Gallbladder carcinoma (GBC) has a poor prognosis. Studies demonstrated that teaching facilities may provide a lower risk of mortality in patients undergoing pancreatic and colon resection vs nonteaching facilities. We hypothesized that survival rates are higher in academic cancer centers (ACCs) vs community cancer centers (CCCs). Read More

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http://dx.doi.org/10.1002/jso.25907DOI Listing

Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Front Oncol 2020 21;10:536. Epub 2020 Apr 21.

Clinical Cancer Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Comprehensive Genomic Profiling may be informative for novel treatment strategies and to improve outcomes for patients with rare tumors. This study aims to discover opportunities for use of targeted therapies already approved for routine use in patients with rare tumors. Solid tumors with an incidence lower than 2. Read More

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http://dx.doi.org/10.3389/fonc.2020.00536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186305PMC

Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma.

Acta Biochim Biophys Sin (Shanghai) 2020 May;52(5):475-484

Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Cholangiocarcinoma (CCA) and gallbladder carcinoma (GBC) are biliary tract cancers with poor five-year survival and high recurrence rates. Both CCA and GBC patients suffer from lack of circulating diagnostic biomarkers at the early stage. Extracellular vesicles, especially exosomes, have been emerged as promising diagnostic sources for cancers due to easy and quick accessibility. Read More

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http://dx.doi.org/10.1093/abbs/gmaa028DOI Listing

Gallbladder Neuroendocrine Carcinoma: A Rare Endocrine Tumor.

Cureus 2020 Mar 31;12(3):e7487. Epub 2020 Mar 31.

Internal Medicine, Indiana University Health, Indianapolis, USA.

Gallbladder neuroendocrine neoplasms (GB-NEN) are very rare neuroendocrine tumors (NETs). GB-NEN can present as carcinoid or typical/atypical carcinoid or small cell carcinoma. Most of the GB-NENs present as gall bladder polyps or stones with right upper quadrant pain, nausea and non-specific symptoms which leads to clinical misdiagnosis. Read More

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http://dx.doi.org/10.7759/cureus.7487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192559PMC