6,740 results match your criteria Gallbladder Carcinoma


Case of successful endoscopic ultrasonography-guided gastrojejunostomy for gastric outlet obstruction caused by gallbladder carcinoma.

Dig Endosc 2019 Apr;31 Suppl 1:66-67

Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1111/den.13360DOI Listing

Detection of NRG1 gene fusions in solid tumors.

Clin Cancer Res 2019 Apr 15. Epub 2019 Apr 15.

Medical Oncology, Georgetown University

Background: NRG1 gene fusions are rare but potentially actionable oncogenic drivers present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking. Here, we assessed the incidence of NRG1 fusions across multiple tumor types and described fusion partners. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0160DOI Listing
April 2019
1 Read

Radiological findings and surgical outcomes of pulmonary metastases originating from biliary tract carcinoma.

Gen Thorac Cardiovasc Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: Metastasis to the lungs arising from biliary tract carcinoma (BTC) is extremely rare, and the patient characteristics and prognosis are not well known. We aimed to identify the imaging findings of pulmonary metastases originating from BTC and the eligible indications for surgical treatment.

Methods: Fifteen patients who underwent pulmonary resection for metastases originating from BTC were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s11748-019-01122-6DOI Listing
April 2019
1 Read

The higher HLA class I expression in cancer cells at early stage lead to high sensitivity for cytotoxic T lymphocytes.

Cancer Sci 2019 Apr 11. Epub 2019 Apr 11.

Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center.

Human lymphocyte antigen (HLA) class I molecules play a central role in cytotoxic T lymphocytes (CTLs)-based antitumor immunity. However, the expression rate of HLA class I in cancer cells still remain discussing. We compared HLA class I expression levels between cancer cells and surrounding non-tumorous hepatocytes in 20 early-stage hepatocellular carcinoma (HCC) patients by immunohistochemistry using EMR 8-5. Read More

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http://dx.doi.org/10.1111/cas.14022DOI Listing
April 2019
1 Read

Lymphatic spread of T2 gallbladder carcinoma: Regional lymphadenectomy is required independent of tumor location.

Eur J Surg Oncol 2019 Mar 30. Epub 2019 Mar 30.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan.

Background: This study aimed to investigate the incidence and distribution of regional lymph node metastasis according to tumor location, and to clarify whether tumor location could determine the extent of regional lymphadenectomy in patients with pathological T2 (pT2) gallbladder carcinoma.

Methods: In total, 81 patients with pT2 gallbladder carcinoma (25 with pT2a tumors and 56 with pT2b tumors) who underwent radical resection were enrolled. Tumor location was determined histologically in each gallbladder specimen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983193038
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http://dx.doi.org/10.1016/j.ejso.2019.03.038DOI Listing
March 2019
3 Reads

Guidelines Insights: Hepatobiliary Cancers, Version 2.2019.

J Natl Compr Canc Netw 2019 Apr;17(4):302-310

28National Comprehensive Cancer Network.

The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations for cancers of the liver, gallbladder, and bile ducts. The NCCN Hepatobiliary Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's discussion and updated recommendations regarding systemic therapy for first-line and subsequent-line treatment of patients with hepatocellular carcinoma. Read More

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http://dx.doi.org/10.6004/jnccn.2019.0019DOI Listing
April 2019
2 Reads

Calcified gallbladder cancer: is it preventable?

J Surg Case Rep 2019 Mar 22;2019(3):rjz069. Epub 2019 Mar 22.

General Surgery Department, West Hertfordshire Hospitals NHS Trust, UK.

A case of a newly diagnosed calcified gallbladder cancer is presented, who had pre-existing porcelain gallbladder. Due to the advanced stage of the disease at presentation, the patient had a poor outcome. The investigation and management of gallbladder carcinoma is discussed as well as the relationship with porcelain gallbladder. Read More

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http://dx.doi.org/10.1093/jscr/rjz069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439505PMC
March 2019
1 Read

Porphyria cutanea tarda increases risk of hepatocellular carcinoma and premature death: a nationwide cohort study.

Orphanet J Rare Dis 2019 Apr 3;14(1):77. Epub 2019 Apr 3.

Norwegian Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway.

Background: Porphyria cutanea tarda (PCT) is a skin disorder originating from a deficit of the liver enzyme uroporphyrinogen decarboxylase. PCT may be a risk factor for hepatocellular carcinoma (HCC) and other cancers, but the evidence is unclear. We aimed to investigate cancer and premature mortality risk in persons with PCT. Read More

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http://dx.doi.org/10.1186/s13023-019-1051-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448269PMC
April 2019
2 Reads

[Clinical study of S-1 single agent adjuvant chemotherapy in the radical resection of extrahepatic biliary carcinoma].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):271-276

Department of Hepatobiliary-Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

To explore the clinical efficacy of S-1 single agent adjuvant chemotherapy for the patients undergoing radical resection of extrahepatic biliary carcinoma. The clinical data of 108 patients with extrahepatic biliary carcinoma receiving radical resection who were admitted from January 2014 to June 2017 were retrospectively analyzed. There were 62 males(57. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.006DOI Listing
April 2019
1 Read

[Diagnosis and treatment for unexpected gallbladder carcinoma(a retrospective study of 45 cases)].

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):265-270

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

To investigate the rationale for appropriate diagnostic methods and treatment protocols for unexpected gallbladder carcinoma(UGC). The clinical and pathological data of 45 patients with UGC admitted at Department of General Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine,from January 2008 to December 2017 were retrospectively collected and analyzed.There were 11 males(28. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.04.005DOI Listing
April 2019
2 Reads

Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.

Pathol Oncol Res 2019 Mar 29. Epub 2019 Mar 29.

Dental Research Center, Dentistry Research Institute, Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

All different types of metabolism of tumors are dependent on the flow of water molecules through the biological membrane, where fluid transfer interceded by aquaporins (AQPs) are the basis means for water entrance into the cells or outside them. Aquaporins play other roles including cellular migration, cellular expansion and cellular adhesion facilitation. Therefore, regulators of AQPs may be useful anticancer agents. Read More

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http://dx.doi.org/10.1007/s12253-019-00646-9DOI Listing

[Metastases in trocar sites secondary to gallbladder adenocarcinoma].

Pan Afr Med J 2018;31:52. Epub 2018 Sep 24.

Service de Chirurgie Viscérale et Digestive de l'Hôpital Militaire d'Instruction Mohamed V de Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2018.31.52.14630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431412PMC
April 2019
2 Reads

Cholecystoduodenal fistula caused by aggressive mucinous gallbladder carcinoma with a porcelain gallbladder.

Clin J Gastroenterol 2019 Mar 27. Epub 2019 Mar 27.

Division of Gastroenterology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, Kobe, Hyogo, 651-0072, Japan.

Cholecystoduodenal fistula secondary to gallbladder carcinoma (GBC) is extremely rare and develops when the tumor penetrates into the adjacent duodenum. A porcelain gallbladder is also a very rare entity that involves the calcification of the gallbladder wall and can be associated with the development of GBC. Herein, we report an unusual case of a patient with cholecystoduodenal fistula, which has been caused by aggressive mucinous gallbladder carcinoma with a porcelain gallbladder. Read More

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http://dx.doi.org/10.1007/s12328-019-00969-9DOI Listing
March 2019
1 Read

A Novel Approach for the Genetic Analysis of Biliary Tract Cancer Specimens Obtained Through Endoscopic Ultrasound-Guided Fine Needle Aspiration Using Targeted Amplicon Sequencing.

Clin Transl Gastroenterol 2019 Mar;10(3):e00022

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Sapporo, Japan.

Objectives: Biliary tract cancer (BTC) is an aggressive malignant tumor, and biomarker-based clinical trials for this cancer are currently ongoing. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a safe procedure and enables pathological diagnoses; however, it is uncertain whether a tiny tumor sample of BTC obtained through EUS-FNA can be analyzed for diverse genetic alterations in the development and tolerance of BTC. Thus, we aimed to verify the feasibility of genetic analyses with EUS-FNA samples of BTC. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445609PMC
March 2019
1 Read

Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report.

World J Surg Oncol 2019 Mar 22;17(1):55. Epub 2019 Mar 22.

Faculty of Medicine in Pilsen, Charles University, 301 00, Pilsen, Czech Republic.

Background: Mixed neuroendocrine-non-neuroendocrine tumors (MINEN) of the gallbladder are extremely rare; indeed, the English expert literature reports a mere handful of case reports and case series on this topic. According to the WHO classification of 2010, MINEN are considered to be tumors consisting of two major components, neuroendocrine and non-neuroendocrine, each of which hosts at least 30% of the total cellular population. To date, the etiology and pathogenesis of MINEN have not been precisely determined and the non-specific symptoms generally result in late diagnosis (mainly in the terminal stages of the condition) and contribute to the generally poor prognosis. Read More

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http://dx.doi.org/10.1186/s12957-019-1598-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429764PMC
March 2019
1 Read

Clinicopathologic Features and Surgical Outcomes of Neuroendocrine Carcinoma of the Gallbladder.

Surg Technol Int 2019 Mar 19;34. Epub 2019 Mar 19.

Department of Clinical Oncology, Kochi Health Sciences Center, Kochi, Japan.

Neuroendocrine carcinoma (NEC) of the gallbladder is highly aggressive and has a poor prognosis even after curative resection. The purpose of this study was to collate and analyze published data to clarify the surgical outcome of NEC of the gallbladder and the relationships between potential prognostic factors and survival after surgery. We surveyed worldwide literature from 1981 to 2018 and obtained clinicopathological data for 65 patients who had undergone surgical resection for NEC of the gallbladder. Read More

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March 2019
2 Reads

Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.

Sci Rep 2019 Mar 18;9(1):4796. Epub 2019 Mar 18.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Gallbladder carcinoma (GBC) is a biliary tract cancer with few treatment options and poor prognosis. Radical surgery is the only potentially curative treatment option but most patients diagnosed with GBC are unresectable. Thus, there is a great need for the development of new treatment options including targeted therapy. Read More

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http://dx.doi.org/10.1038/s41598-019-40857-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423323PMC
March 2019
7 Reads

Can surgical treatment be justified for neuroendocrine carcinoma of the gallbladder?

Medicine (Baltimore) 2019 Mar;98(11):e14886

Department of Surgery, Seoul National University College of Medicine, Surgery, Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.

Clinical features and treatment of GB neuroendocrine carcinoma (GB-NEC) are not well understood. This study aimed to analyze clinical outcomes of GB-NEC and verify the oncologic benefit of surgical treatment.From October 1994 to December 2014, the medical records of 31 patients with GB-NEC at a single center were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426572PMC
March 2019
5 Reads

Massive hemoperitoneum and upper gastrointestinal hemorrhage following liver rupture secondary to gallbladder perforation: A case report and literature review.

Medicine (Baltimore) 2019 Mar;98(11):e14729

Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chendu, Sichuan.

Rationale: Available literature states that the common reasons for non-traumatic spontaneous liver rupture are hepatocellular carcinoma, macronodular cirrhosis, hemangioma, and other tumors; gallbladder perforation is not cited as a cause.

Patient Concerns: The patient presented with sudden-onset right upper quadrant pain with tarry stool for 3 days after eating with dysphoria and increasing thirst; gradually, hemorrhagic shock developed. He had no history of trauma, no background of chronic hepatitis, and no cirrhosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426586PMC
March 2019
1 Read

Prospective observational study on cholelithiasis in patients with carcinoma gall bladder in a tertiary referral hospital of Eastern India.

J Cancer Res Ther 2019 Jan-Mar;15(1):153-156

Department of Surgery, IPGMER/SSKM Hospital; Department of Surgical Oncology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.

Context: Gallbladder carcinoma (GBCA) is the fifth most common types of gastrointestinal malignancy and is the most common malignancy of the biliary tract. Cholelithiasis, gallbladder polyps, porcelain gall, and choledochal cysts are common known associations with GBCA. Because of the better understanding of the etiopathogenesis, the traditional nihilistic attitude toward the prognosis has, over the years, given way to greater interest and hope for treating the disease. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_939_17DOI Listing
March 2019
2 Reads

Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease.

Biosci Trends 2019 ;13(1):1-9

Department of Oncology, XinHua Hospital, Shanghai Jiao Tong University.

Since the American Joint Committee on Cancer (AJCC) subdivided the T2 stage of gallbladder carcinoma (GBC) into T2a and T2b, the diagnosis and treatment of those stages have been a subject of heated discussion and controversy. T2 is a stage of GBC that might be treatable. Based on the extent of lymph node metastasis and distant metastasis, T2 GBC can be classified into various pathological stages such as IIA, IIB, IIIB, and IVB, leading to controversy in clinical settings. Read More

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http://dx.doi.org/10.5582/bst.2019.01039DOI Listing
January 2019
2 Reads

Preoperative fasting hyperglycemia is an independent prognostic factor for postoperative survival after gallbladder carcinoma radical surgery.

Cancer Manag Res 2019 12;11:1425-1432. Epub 2019 Feb 12.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China,

Background: Preoperative high blood glucose levels are closely associated with poor performance and high mortality in cancer patients. This study was designed to investigate the relationship between preoperative fasting hyperglycemia and the prognosis of patients with gallbladder cancer (GBC) after undergoing GBC radical surgery.

Patients And Methods: A retrospective analysis of 83 eligible patients who underwent GBC radical surgery between 2007 and 2016 was performed. Read More

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http://dx.doi.org/10.2147/CMAR.S192273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388958PMC
February 2019

[Metachronous intraductal papillary mucinous carcinoma five years after cholecystectomy for gallbladder cancer in a patient with pancreaticobiliary maljunction].

Nihon Shokakibyo Gakkai Zasshi 2019;116(3):241-248

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

A 71-year-old female with non-dilated pancreaticobiliary maljunction (PBM) and gallbladder polypoid lesions underwent laparoscopic cholecystectomy. Histological examination of the polypoid lesions revealed gallbladder cancer. Five years after cholecystectomy, gradual dilatation of the main pancreatic duct (MPD) led to the identification of a papillary tumor growing in the MPD of the pancreatic head. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.241DOI Listing
January 2019
3 Reads

Uncommon site of metastasis from renal cell carcinoma: Case report.

Int J Surg Case Rep 2019 13;56:45-48. Epub 2019 Feb 13.

Department of Oncology, Real e Benemérita Associação Portuguesa de Beneficência, Brazil.

Background: Renal cell carcinomas (CCR) account for 90% of renal tumors. Presence of latent distant metastasis is characteristic of RCC and may manifest more than a decade after nephrectomy. Gallbladder (GB) is a rare site of metastasis, with few reports in the literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193007
Publisher Site
http://dx.doi.org/10.1016/j.ijscr.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406048PMC
February 2019
8 Reads

[Gallbladder epidermoid carcinoma].

Rev Med Chil 2018 Dec;146(12):1438-1443

Departamento de Cirugía Oncológica Gastrointestinal, Instituto Nacional de Cancerología, México.

Background: Gallbladder epidermoid carcinoma is rare and more common in women over 55 years of age.

Aim: To report the features of 15 patients with gallbladder epidermoid carcinoma.

Material And Methods: Review of medical records of patients with gallbladder cancer in an oncology service. Read More

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http://dx.doi.org/10.4067/s0034-98872018001201438DOI Listing
December 2018
5 Reads

Histopathological Examination of Gallbladder Specimens in Kumaon Region of Uttarakhand.

J Gastrointest Cancer 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Government Medical College, Haldwani, Nainital, Uttarakhand, 263139, India.

Gall stones are one of the major causes of morbidity and mortality all over the world and common health problems throughout in developing countries. Cholecystectomy is one of the most common surgical practices and postoperative analysis of cholecystectomy specimen has a great value since histopathological reports may document some entities with significant clinical significances. Gallbladder carcinomas in cholecystectomy specimens are received in our histopathology laboratory to analyse their clinicopathological features. Read More

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http://dx.doi.org/10.1007/s12029-018-00188-4DOI Listing
March 2019
6 Reads

Cholesterol Granuloma Masquerading as Gallbladder Carcinoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Mar 1. Epub 2019 Mar 1.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

F-FDG PET/CT was performed on a 70-year-old man to stage the newly diagnosed multiple myeloma. A hypermetabolic lesion in the gallbladder fundus was revealed incidentally and suspected for gallbladder carcinoma, but was finally proven to be a cholesterol granuloma by the pathology of cholecystectomy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002517DOI Listing
March 2019
4 Reads
3.931 Impact Factor

Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):967-999. Epub 2019 Mar 1.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Objective: The abnormal expression of the key enzymes in glycolytic pathways, including glucose transporter-1, glucose transporter-3, hexokinase-II, lactate dehydrogenase 5, pyruvate kinase M2, glucose-6-phosphate dehydrogenase, transketolase-like protein 1 and pyruvate dehydrogenase kinase-1 was reported to be associated with poor prognosis of various cancers. However, the association remains controversial. The objective of this study was to investigate the prognostic significance of glycolysis-related proteins. Read More

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http://dx.doi.org/10.1007/s00432-019-02847-wDOI Listing
April 2019
2 Reads

An unusual presentation of carcinoma in gallbladder.

Cytojournal 2019 22;16. Epub 2019 Jan 22.

Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/cytojournal.cytojournal_15_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367905PMC
January 2019

Fine-needle aspiration cytology of gallbladder with an attempt of cytomorphological classification.

Cytojournal 2019 22;16. Epub 2019 Jan 22.

Department of Surgery, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Background: Image-guided fine-needle aspiration has emerged as an effective diagnostic tool for precise diagnosis of deep-seated lesions. Although occasional studies have made an attempt to classify the gallbladder carcinoma on cytology, literature lacks the standardized cytological nomenclature system used for it. The present study was conducted to study the role of fine-needle aspiration cytology (FNAC) in diagnosis of gallbladder lesions with an attempt of cytomorphological classification. Read More

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http://dx.doi.org/10.4103/cytojournal.cytojournal_5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367906PMC
January 2019
1 Read

Central Venous Catheter as Peritoneal Indwelling Catheter for the Management of Recurrent Malignant Ascites: A Case Series.

Indian J Palliat Care 2019 Jan-Mar;25(1):57-60

Department of Oncoanaesthesia and Palliative Medicine, Dr. B.R. Ambedkar IRCH, AIIMS, New Delhi, India.

Background: Malignant ascites is an accumulation of fluid in the peritoneal cavity due to the manifestation of terminal metastatic malignancies. Accumulation of ascitic fluid could cause abdominal distention, early satiety, and shortness of breath. The onset and progression of these symptoms are not only distressing but also cause deterioration of the quality of life. Read More

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http://dx.doi.org/10.4103/IJPC.IJPC_145_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388607PMC
March 2019
5 Reads

Prognostic significance of neutrophil-lymphocyte ratio and carbohydrate antigen 19-9 in patients with gallbladder carcinoma.

Medicine (Baltimore) 2019 Feb;98(8):e14550

Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Si chuan Province, China.

The neutrophil-lymphocyte ratio (NLR) is an immune response-related indicator and it is associated with poor prognosis of various cancers. The carbohydrate antigen19-9 (CA19-9) is a tumor-associated antigen and it has prognostic relevance in gallbladder carcinoma (GBC). We aimed to analyze whether preoperative NLR and serum CA19-9 were associated with outcomes of GBC patients after surgery with curative intent. Read More

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http://dx.doi.org/10.1097/MD.0000000000014550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407978PMC
February 2019
1 Read

Biliary Neuroendocrine Neoplasms: Clinical Profiles, Management, and Analysis of Prognostic Factors.

Front Oncol 2019 5;9:38. Epub 2019 Feb 5.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Biliary neuroendocrine neoplasms (NENs) represent <1% of all NENs. The aim of this retrospective study is to present the clinical characteristics, management and prognosis profiles of 28 biliary NEN patients from a large tertiary center, and identify factors related to prognosis. Nine tumors originated from the gallbladder, two from the extrahepatic bile duct and 17 from the ampulla of Vater. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00038/
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http://dx.doi.org/10.3389/fonc.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370735PMC
February 2019
2 Reads

Extended resection for xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: Cases and review of diagnostic approach.

J Pak Med Assoc 2019 Feb;69(2):256-260

Aga Khan University, KARACHI, PAKISTAN.

Xanthogranulomatous cholecystitis is a rare variant of chronic cholecystitis, which can involve adjacent organs including liver, colon and duodenum mimicking gallbladder cancer. Preoperative and intraoperative differentiation of xanthogranulomatous cholecystitis from gallbladder cancer is often difficult and the final diagnosis is made on histopathology of the resected specimen. We hereby report four cases of xanthogranulomatous chol ec ystitis w hich were misdiagnosed as cases of advanced gallbladder cancer based on presentation and radiological findings and underwent radical resections but the final histopathology was a diagnostic surprise. Read More

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February 2019
2 Reads

Robotic hepatectomy for benign and malignant liver tumors.

J Robot Surg 2019 Feb 23. Epub 2019 Feb 23.

Digestive Disease Institute, Florida Hospital Tampa, 3000 Medical Park Dr, Suite #500, Tampa, FL, 33613, USA.

Minimally invasive hepatectomy for benign and malignant liver lesions has gained popularity in the past decade due to improved perioperative outcomes when compared to conventional 'open' technique. We aim to investigate our initial experience of robotic hepatectomy undertaken in our hepatobiliary program. All patients undergoing robotic hepatectomy between 2013 and 2018 were prospectively followed. Read More

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http://dx.doi.org/10.1007/s11701-019-00935-0DOI Listing
February 2019
1 Read

Multimodality management of incidentally detected gall bladder cancer: long term results from a tertiary care cancer centre.

J Gastrointest Oncol 2019 Feb;10(1):128-133

Department of Surgical Oncology, All India Institute of Medical sciences (AIIMS), New Delhi, India.

Background: Gall bladder cancer (GBC) is the most common biliary tract malignancy in India. GBC present either with incidental diagnosis after simple cholecystectomy (SC) or with a primary gall bladder mass. Incidentally detected gall bladder cancer (ICGB) has traditionally been thought to be a relatively early stage disease but there are controversies associated with various aspects of its management. Read More

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http://dx.doi.org/10.21037/jgo.2018.09.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351296PMC
February 2019

Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies.

World J Gastroenterol 2019 Feb;25(6):659-671

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra- and/or extrahepatic biliary ducts. While its features and disease course can be variable, most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378537PMC
February 2019
3 Reads

Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 03;48(3):412-419

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
March 2019
11 Reads
2.959 Impact Factor

[A Case of Abdominal Compartment Syndrome after Laparotomy for Peritonitis Caused by Colon Perforation Due to Gallbladder Carcinoma].

Gan To Kagaku Ryoho 2019 Jan;46(1):157-159

Dept. of Surgery, Kansai Medical University.

A70 -year-old man with a diagnosis of panperitonitis caused by colon perforation due to invasion of gallbladder cancer was transferred to our hospital. The next day, an emergency operation was performed. During laparotomy, the ascending colon was perforated; therefore, ileocecal resection was performed. Read More

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January 2019
1 Read

Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.

J Gastrointest Surg 2019 Apr 12;23(4):818-824. Epub 2019 Feb 12.

Section of Hepatobiliary and Pancreatic Surgery, Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Background: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease.

Materials And Methods: We maintain a prospective high volume gastrointestinal malignancy PDX program. Read More

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http://dx.doi.org/10.1007/s11605-019-04109-zDOI Listing
April 2019
1 Read

Gallbladder Polyps: Real or Imagined?

Am Surg 2018 Oct;84(10):1670-1674

Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

The finding of gallbladder polyps on imaging studies prompts further workup. Imaging results are often discordant with final pathology. The goal of this study is to compare polypoid lesions of the gallbladder found on preoperative ultrasound (US) with final pathologic diagnosis after cholecystectomy to help guide clinical decision-making. Read More

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October 2018
12 Reads

Elucidation of the chemopreventive role of stigmasterol against Jab1 in Gall bladder carcinoma.

Endocr Metab Immune Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow. India.

Background: Plant sterols have proven a potent anti-proliferative and apoptosis inducing agent against several carcinomas including breast and prostate cancers. Jab1 has been reported to be involved in the progression of numerous carcinomas. However, antiproliferative effects of sterols against Jab1 in gall bladder cancer have not been explored yet. Read More

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http://dx.doi.org/10.2174/1871530319666190206124120DOI Listing
February 2019
6 Reads

Systematically Characterizing Chemical Profile and Potential Mechanisms of Qingre Lidan Decoction Acting on Cholelithiasis by Integrating UHPLC-QTOF-MS and Network Target Analysis.

Evid Based Complement Alternat Med 2019 3;2019:2675287. Epub 2019 Jan 3.

Institute of Integrative Medicine, Dalian Medical University, No. 9, South Road of Lvshun, Dalian 116044, China.

Qingre Lidan Decoction (QRLDD), a classic precompounded prescription, is widely used as an effective treatment for cholelithiasis clinically. However, its chemical profile and mechanism have not been characterized and elucidated. In the present study, a rapid, sensitive, and reliable ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established for comprehensively identifying the major constituents in QRLDD. Read More

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http://dx.doi.org/10.1155/2019/2675287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335670PMC
January 2019
1 Read

Neuroendocrine carcinoma of gallbladder: a case series and literature review.

Eur J Med Res 2019 Feb 4;24(1). Epub 2019 Feb 4.

Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic of China.

Background: Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported.

Case Presentation: Eight gallbladder NEC patients were admitted into our hospital. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-019-0363-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362567PMC
February 2019
11 Reads

Long non-coding RNA DILC promotes the progression of gallbladder carcinoma.

Gene 2019 Apr 1;694:102-110. Epub 2019 Feb 1.

Department of Biliary Tract Surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai 200438, China. Electronic address:

Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) contribute to tumorigenesis, progression and recurrence of various malignancies including Gallbladder carcinoma (GBC). Lnc-DILC is reported to be the tumor suppressor gene to play an important role in liver cancer stem cells (CSCs). However, the role of lnc-DILC in GBC remains to be elucidated. Read More

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http://dx.doi.org/10.1016/j.gene.2018.12.086DOI Listing
April 2019
2 Reads

Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report.

Surg Case Rep 2019 Feb 4;5(1):17. Epub 2019 Feb 4.

Department of Surgery, Maizuru Medical Center, Kyoto, Japan.

Background: Metastases to the stomach or gallbladder from any malignancy is rarely noted, and simultaneous metastases to both organs are atypical. We present a unique case of simultaneous multifocal metastases of the stomach and gallbladder from renal cell carcinoma (RCC).

Case Presentation: The case involved a 60-year-old man, with a past history of RCC (clear cell type, G2, T1b N0 M0 Stage I) treated by a right nephrectomy. Read More

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http://dx.doi.org/10.1186/s40792-019-0569-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364323PMC
February 2019
2 Reads

Surgical treatment of malignant biliary papillomatosis invading adjacent organs: A case report.

World J Clin Cases 2019 Jan;7(2):253-259

Department of Plastic and Burn Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Biliary papillomatosis (BP) is a rare disease characterized by multiple papillary adenomas in the intrahepatic and extrahepatic biliary tree and has a high risk of malignant transformation. Early diagnosis and treatment for BP are challenges, as it spreads along the biliary tract. A radical resection with an adequate resection margin is advocated in patients with malignant BP. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i2.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354098PMC
January 2019
2 Reads

Gallbladder metastasis from renal cell carcinoma: A case report and literature review.

Urol Case Rep 2019 Mar 8;23:69-71. Epub 2019 Jan 8.

Department of Urology, Daiyukai Daiichi Hospital, 1-6-12 Hagoromo, Ichinomiya City, Aichi, 491-0025, Japan.

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http://dx.doi.org/10.1016/j.eucr.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348693PMC
March 2019
2 Reads

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study.

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

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http://dx.doi.org/10.2196/10677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371071PMC
January 2019
3 Reads
3.428 Impact Factor