13,551 results match your criteria Gallbladder Cancer


Advanced laparoscopic HPB surgery: Experience in Seoul National University Bundang Hospital.

Ann Gastroenterol Surg 2020 May 25;4(3):224-228. Epub 2020 Mar 25.

Seoul National University Bundang Hospital Gyeonggi-do Korea.

The worldwide trend in surgery has moved from open surgery to minimally invasive surgery. Likewise, the application of minimally invasive surgery in the hepato-pancreato-biliary (HBP) field is also rapidly expanding. The field of HBP surgery can be divided into liver, pancreas and biliary fields. Read More

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http://dx.doi.org/10.1002/ags3.12323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240149PMC

Hemorrhagic Cholecystitis in a Patient with Cirrhosis and Rectal Cancer.

Cureus 2020 Apr 29;12(4):e7882. Epub 2020 Apr 29.

Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Hemorrhagic cholecystitis is a rare presentation of acute calculous cholecystitis which presents with abdominal pain, jaundice, and gastrointestinal bleeding. It is a challenging diagnosis to make because it present similar to other common disorders such as calculous cholecystitis. We present a unique case of hemorrhagic cholecystitis in a patient with cirrhosis and rectal cancer. Read More

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http://dx.doi.org/10.7759/cureus.7882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255552PMC

Interleukin 17A promotes gallbladder cancer invasiveness via ERK/NF-κB signal pathway mediated epithelial-to-mesenchymal transition.

J Cancer 2020 18;11(15):4406-4412. Epub 2020 May 18.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

As a pro-inflammatory cytokine, Interleukin 17A (IL-17A) plays an important role in pathology of tumor microenvironment and inflammatory diseases. In this study, we intend to investigate the role of IL-17A on the metastasis of gallbladder cancer (GBC) and related mechanisms. The serum levels of IL-17A were associated with node metastasis and advanced stage. Read More

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http://dx.doi.org/10.7150/jca.40656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255371PMC

[Pathological characteristics and survival analysis of 355 patients with gastroenteropancreatic neuroendocrine neoplasms].

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):426-431

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. In our study, 355 patients pathologically diagnosed as GEP-NENs were identified from April 2006 to November 2017 in the Fourth Hospital of Hebei Medical University. The biological behavior, pathological characteristics and prognosis were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-112152-20191011-00663DOI Listing

The Landmark Series: Gallbladder Cancer.

Ann Surg Oncol 2020 May 30. Epub 2020 May 30.

Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Given the rarity of gallbladder carcinoma, level I evidence to guide the multimodal treatment of this disease is lacking. Since 2010, four randomized phase III clinical trials including ABC-02, PRODIGE-12/ACCORD-18, BILCAP, and BCAT, and a single-arm phase II trial (SWOG0809) have been reported on the use of adjuvant strategies for biliary malignancies. These trials have led to the recommendation that patients with resected biliary tract cancer should be offered adjuvant capecitabine chemotherapy and those with R1 margins could be considered for chemoradiotherapy. Read More

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http://dx.doi.org/10.1245/s10434-020-08654-9DOI Listing

The management of gallbladder polyps.

J Visc Surg 2020 May 27. Epub 2020 May 27.

Digestive and transplantation Department, Lille Nord de France University, Claude Huriez Hospital, University Hospital of Lille, rue Michel-Polonovski, 59037 Lille, France.

Neoplastic gallbladder polyps (NGP) are rare; the prevalence in the overall population is less than 10%. NGP are associated with a risk of malignant degeneration and must be distinguished from other benign gallbladder polypoid lesions that occur more frequently. NGP are adenomas and the main risk associated with their management is to fail to detect their progression to gallbladder cancer, which is associated with a particular poor prognosis. Read More

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http://dx.doi.org/10.1016/j.jviscsurg.2020.04.008DOI Listing

Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.

Diagn Pathol 2020 May 27;15(1):63. Epub 2020 May 27.

Department of Pathology, Jeonbuk National University Medical School, 567 Baekje-daero, Dukjin-gu, Jeonju, 54896, Republic of Korea.

Background: Recently, FAM83H was reported to have roles in cancer progression in conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from the public database indicates a molecular relationship between FAM83H and zinc finger proteins, especially between FAM83H and ZNF16. However, studies on FAM83H and ZNF16 in gallbladder cancer have been limited. Read More

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http://dx.doi.org/10.1186/s13000-020-00985-1DOI Listing

Effect of lymphadenectomy in curative gallbladder cancer treatment: a systematic review and meta-analysis.

Langenbecks Arch Surg 2020 May 26. Epub 2020 May 26.

Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007, St. Gallen, Switzerland.

Purpose: Only a small fraction of resectable gallbladder cancer (GBC) patients receive a thorough lymphadenectomy. The aim of this systematic review and meta-analysis was to investigate the effect of lymphadenectomy on survival in GBC surgery.

Methods: On May 19, 2019, MEDLINE, EMBASE, and the Cochrane Library were searched for English or German articles published since 2002. Read More

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http://dx.doi.org/10.1007/s00423-020-01878-zDOI Listing

Application of Neural Network and Cluster Analyses to Differentiate TCM Patterns in Patients With Breast Cancer.

Front Pharmacol 2020 8;11:670. Epub 2020 May 8.

Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.

Background And Purpose: Pattern differentiation is a critical element of the prescription process for Traditional Chinese Medicine (TCM) practitioners. Application of advanced machine learning techniques will enhance the effectiveness of TCM in clinical practice. The aim of this study is to explore the relationships between clinical features and TCM patterns in breast cancer patients. Read More

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http://dx.doi.org/10.3389/fphar.2020.00670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227602PMC

Management of intractable pancreatic leak from iatrogenic pancreatic duct injury following resection of choledochal cyst in an adult patient.

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):228-233

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Iatrogenic pancreatic duct injury can occur during resection of the choledochal cyst (CC). We herein present a case of postoperative pancreatic fistula (POPF) developed after resection of the CC in an adult patient with variant anomalous union of pancreatobiliary duct. The 55-year-old female patient underwent surgery after the diagnosis of CC-associated gallbladder cancer. Read More

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http://dx.doi.org/10.14701/ahbps.2020.24.2.228DOI Listing

A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer.

Cancer 2020 May 26. Epub 2020 May 26.

Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Background: Regorafenib is an oral multikinase inhibitor targeting angiogenesis, oncogenesis, and cancer proliferation/metastasis. This study evaluated the efficacy of regorafenib in refractory biliary tract cancer (BTC) in a multi-institutional phase 2 study.

Methods: Patients with BTC who progressed on at least 1 line of systemic therapy received regorafenib at 160 mg daily for 21 days on and 7 days off. Read More

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http://dx.doi.org/10.1002/cncr.32964DOI Listing

Role of tumour location and surgical extent on prognosis in T2 gallbladder cancer: an international multicentre study.

Br J Surg 2020 May 26. Epub 2020 May 26.

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: In gallbladder cancer, stage T2 is subdivided by tumour location into lesions on the peritoneal side (T2a) or hepatic side (T2b). For tumours on the peritoneal side (T2a), it has been suggested that liver resection may be omitted without compromising the prognosis. However, data to validate this argument are lacking. Read More

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http://dx.doi.org/10.1002/bjs.11618DOI Listing

[Obesity and Pancreatobiliary Disease].

Korean J Gastroenterol 2020 May;75(5):240-245

Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Obesity has become a major medical and public health problem worldwide. Recent studies have shown that obesity is a chronic disease that is associated with many diseases, such as gallstone disease, acute pancreatitis, fatty liver, and digestive cancer. Obesity is also a risk factor for the formation of cholesterol gallstones. Read More

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http://dx.doi.org/10.4166/kjg.2020.75.5.240DOI Listing

Landmark survival analysis and impact of anatomic origin in prospective clinical trials of biliary tract cancer.

J Hepatol 2020 May 21. Epub 2020 May 21.

Division of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester M20 4BX, UK.

Background: Inclusion of all patients with advanced biliary tract cancer (aBTC), irrespective of anatomic location, in prospective trials, is debated. Survival rates from landmark analysis offer more relevant information once patients have survived for some time.

Aim: assess survival impact of BTC anatomic site origin and landmark survival (LS). Read More

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http://dx.doi.org/10.1016/j.jhep.2020.05.014DOI Listing

Effects of Primary Sclerosing Cholangitis on Risks of Cancer and Death in People With Inflammatory Bowel Diseases, Based on Sex, Race, and Age.

Gastroenterology 2020 May 20. Epub 2020 May 20.

NIHR Birmingham Biomedical Research Centre, Centre for Liver and Gastroenterology Research, University of Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, UK; Toronto Centre for Liver Disease, University Health Network and Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Background & Aims: There are insufficient population-level data on effects of primary sclerosing cholangitis (PSC) in patients with inflammatory bowel disease (IBD).

Methods: We identified incident cases of IBD, with PSC (PSC-IBD) and without, from April 2006 through to April 2016 and collected data on outcomes through April 2019. We linked data from national healthcare registries maintained for all adults in England on hospital attendances, imaging and endoscopic evaluations, surgical procedures, cancer, and deaths. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.05.049DOI Listing

Oncologic safety of laparoscopic radical cholecystectomy in pT2 gallbladder cancer: A propensity score matching analysis compared to open approach.

Medicine (Baltimore) 2020 May;99(20):e20039

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine.

The role of laparoscopic radical cholecystectomy (LRC) in the surgical management of T2 gallbladder carcinoma (GBC) is still controversial.The medical records of patients with T2 GBC treated with radical cholecystectomy were retrospectively reviewed. In this study, we compare the short- and long-term oncologic outcomes, using propensity score matching analysis, of patients with T2 GBC who underwent LRC and open radical cholecystectomy (ORC). Read More

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http://dx.doi.org/10.1097/MD.0000000000020039DOI Listing

Inside the courtroom: An analysis of malpractice litigation in gallbladder surgery.

Surgery 2020 May 18. Epub 2020 May 18.

Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH. Electronic address:

Background: Cholecystectomy is one of the most commonly performed operations in the United States, yet it still carries up to a 6% risk of major morbidity. Lawsuits are a major source of emotional, financial, and personal stress for surgeons. We sought to characterize malpractice claims associated with gallbladder surgery as well as define contributing factors and costs with these claims. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.009DOI Listing

Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project.

J Hepatol 2020 May 10. Epub 2020 May 10.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Background: Gallbladder cancer (GBC) has a female predominance, although other biliary tract cancers (BTCs) such as extrahepatic and intrahepatic bile duct (EHBDC and IHBDC) and ampulla of Vater (AVC) have a male predominance. The role of female reproductive factors in BTC etiology remains unclear.

Methods: We pooled data from 19 studies of >1. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.04.046DOI Listing

Review on gall bladder myeloid sarcoma: a great masquerader.

Chin Clin Oncol 2020 May 20. Epub 2020 May 20.

Hemato-Oncology Division, Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA.

Pain in abdomen has wide differentials and narrowing down the clinical possibilities depends on type of pain, location, characterization which is usually assisted by imaging studies. Cholecystitis and cholelithiasis are amongst the common causes of acute abdomen. This study reviews the literature for the clinical characteristics, differential diagnosis, treatment and prognosis of reported cases of gallbladder myeloid sarcoma (GB-MS) who presented with abdominal symptoms. Read More

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http://dx.doi.org/10.21037/cco-19-250DOI Listing

TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis.

Eur Rev Med Pharmacol Sci 2020 May;24(9):4745-4755

Department of Critical Care Medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, P.R. China.

Objective: Ferroptosis is a recently identified form of controlled cell death generally associated with the accumulation of lipid-associated reactive oxygen species (ROS). However, the molecular mechanisms underlying ferroptosis have not been established.

Materials And Methods: Microarray expression data for three human gallbladder carcinoma (GBC) and matched non-tumour specimens were downloaded from the Gene Expression Omnibus (GEO) repository. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21163DOI Listing

Downregulation of miR-575 Inhibits the Tumorigenesis of Gallbladder Cancer via Targeting p27 Kip1.

Onco Targets Ther 2020 1;13:3667-3676. Epub 2020 May 1.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People's Republic of China.

Background: Gallbladder cancer (GBC) is the most common biliary tract malignant cancer worldwide. It has been reported that microRNA-575 (miR-575) was involved in the tumorigenesis of many cancers. However, the role of miR-575 during the progression of GBC remains largely unknown. Read More

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http://dx.doi.org/10.2147/OTT.S229614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200254PMC

Comparison of lymph node evaluation and yield among patients undergoing open and minimally invasive surgery for gallbladder adenocarcinoma.

Surg Endosc 2020 May 19. Epub 2020 May 19.

Department of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.

Introduction: Assessment of regional lymph nodes (LN) is essential for determining prognosis among patients with gallbladder cancer (GBC). The impact of surgical technique on LN yield has not been well explored. We investigated the impact of minimally invasive surgery (MIS; robotic or laparoscopic) on the evaluation and retrieval of regional LN for patients with GBC. Read More

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http://dx.doi.org/10.1007/s00464-020-07635-zDOI Listing

XRCC1 Is a Promising Predictive Biomarker and Facilitates Chemo-Resistance in Gallbladder Cancer.

Front Mol Biosci 2020 24;7:70. Epub 2020 Apr 24.

Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.

Gallbladder cancer is a relatively uncommon human malignant tumor with an extremely poor prognosis. Currently, no biomarkers can accurately diagnose gallbladder cancer and predict patients' prognosis. XRCC1 is involved in tumorigenesis, progression, and chemo-resistance of several human cancers, but the role of XRCC1 in gallbladder cancer is never reported. Read More

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http://dx.doi.org/10.3389/fmolb.2020.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212355PMC

Biliary Tract Cancer: Current Medical Treatment Strategies.

Cancers (Basel) 2020 May 14;12(5). Epub 2020 May 14.

Department of Clinical Oncology, Fondazione Poliambulanza, 25124 Brescia, Italy.

Background: Biliary tract cancers (BTCs) include cholangiocarcinomas and gallbladder cancers usually present at an advanced stage, which are considered resectable in less than 20% of cases and characterised by poor prognosis.

Methods: In this review, we discussed the most recent therapeutic options on the basis of the most updated and complete reviews and recent prospective studies in selected BTC patients.

Results: Due to the high recurrence rate of BTCs, we suggest the new recommendations that have been made on adjuvant chemotherapy and radiotherapy treatment after surgery. Read More

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http://dx.doi.org/10.3390/cancers12051237DOI Listing

Incidence of and risk factors for late cholecystectomy in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Eur J Cancer 2020 May 15;133:4-13. Epub 2020 May 15.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Department of Paediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

Background: Gallbladder disease and need for cholecystectomy are common and significant contributors to patient morbidity and healthcare costs. Childhood cancer survivors are at elevated risk for developing cholelithiasis. However, their incidence of and risk factors for late (>5 years from diagnosis) cholecystectomy have not been studied. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.03.004DOI Listing

Outcomes of Gallbladder Polyps and Their Association With Gallbladder Cancer in a 20-Year Cohort.

JAMA Netw Open 2020 May 1;3(5):e205143. Epub 2020 May 1.

Division of Research, Kaiser Permanente, Oakland, California.

Importance: Gallbladder polyps (GP) are found in more than 4% of adult abdominal ultrasonographs. Their growth pattern and association with gallbladder cancer (GBC) are poorly defined.

Objective: To determine the growth pattern of GPs and their association with GBC. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.5143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235691PMC

Gallbladder Cancer: Imaging Appearance and Pitfalls in Diagnosis.

Can Assoc Radiol J 2020 May 15:846537120923273. Epub 2020 May 15.

Department of Medical Imaging, The Ottawa Hospital, Ontario, Canada.

Gallbladder cancer is an uncommon malignancy with an overall poor prognosis. The clinical and imaging presentation of gallbladder cancer often overlaps with benign disease, making diagnosis difficult. Gallbladder cancer is most easily diagnosed on imaging when it presents as a mass replacing the gallbladder. Read More

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http://dx.doi.org/10.1177/0846537120923273DOI Listing

Editorial on "A new nomogram from the SEER database for predicting the prognosis of gallbladder cancer patients after surgery".

Ann Transl Med 2020 Apr;8(8):522

Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.21037/atm.2020.03.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214910PMC

Deciphering the Roles of IFITM1 in Tumors.

Mol Diagn Ther 2020 May 11. Epub 2020 May 11.

Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, P.R. China.

Interferon (IFN)-induced transmembrane protein 1 (IFITM1), a member of the IFN-induced transmembrane protein family, is reported to be highly expressed in tumor tissues as well as cancer cell lines, and it is an independent prognostic biomarker for patients with certain tumor types, such as gallbladder carcinoma, esophageal adenocarcinoma, colorectal cancer, and gastric cancer. Moreover, overexpression of IFITM1 promotes tumor cell proliferation, invasion, metastasis, angiogenesis, and therapeutic resistance, including endocrine therapy, chemotherapy, and radiotherapy resistance. Due to these diverse functions of IFITM1 in tumors, targeting IFITM1 may provide a novel strategy for cancer treatment and be highly desirable to improve cancer patient outcomes. Read More

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http://dx.doi.org/10.1007/s40291-020-00469-4DOI Listing

Targeted Therapies in Trial for Non-Resectable Gallbladder Cancer.

J Gastrointest Cancer 2020 May 11. Epub 2020 May 11.

Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Purpose: Gallbladder cancer (GBC) is the most common malignancy of the biliary tract. The median survival of the disease is around 6 months. In this study, we explore clinical trials related to non-resectable GBC, determine the shortcomings leading to the lack of development of new treatment, and shed light on possible areas of improvement. Read More

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http://dx.doi.org/10.1007/s12029-020-00411-1DOI Listing

Detection of microRNA-335-5p on an Interdigitated Electrode Surface for Determination of the Severity of Abdominal Aortic Aneurysms.

Nanoscale Res Lett 2020 May 11;15(1):105. Epub 2020 May 11.

Department of Nuclear Medicine, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.

Abdominal aortic aneurysm (AAA) refers to the enlargement of the lower artery of the abdominal aorta, and identification of an early detection tool is urgently needed for diagnosis. In the current study, an interdigitated electrode (IDE) sensing surface was used to identify miRNA-335-5p, which reflects the formation of AAAs. The uniformity of the silica material was observed by 3D profilometry, and the chemically modified highly conductive surface improved the detection via the I-V mode. Read More

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http://dx.doi.org/10.1186/s11671-020-03331-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214562PMC

Is laparoscopic radical cholecystectomy an effective and safe approach for advanced gallbladder cancer?

Hepatobiliary Pancreat Dis Int 2020 May 3. Epub 2020 May 3.

Division of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital, Zhejiang Shuren University School of Medicine, Hangzhou 310022, China. Electronic address:

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http://dx.doi.org/10.1016/j.hbpd.2020.04.005DOI Listing

Comparison of overall survival in gallbladder carcinoma at academic versus community cancer centers: An analysis of the National Cancer Data Base.

J Surg Oncol 2020 May 7. Epub 2020 May 7.

Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Background And Objectives: Gallbladder carcinoma (GBC) has a poor prognosis. Studies demonstrated that teaching facilities may provide a lower risk of mortality in patients undergoing pancreatic and colon resection vs nonteaching facilities. We hypothesized that survival rates are higher in academic cancer centers (ACCs) vs community cancer centers (CCCs). Read More

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http://dx.doi.org/10.1002/jso.25907DOI Listing

[A Case of Synchronous Gallbladder Metastasis Originating from Advanced Gastric Cancer].

Gan To Kagaku Ryoho 2020 Feb;47(2):376-378

Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.

Gallbladder metastasis from gastric cancer is often found accidentally during postoperative pathological examinations, and its preoperative diagnosis is very difficult. There are a few reports in diagnostic imaging, and it is well known to have a very poor prognosis. There have been 13 reports on gallbladder metastasis from gastric cancer in the Japanese literature. Read More

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February 2020

[Gallbladder Cancer with Multiple Liver Metastases Completely Responding to Gemcitabile plus Cisplatin Chemotherapy-A Case Report].

Gan To Kagaku Ryoho 2020 Feb;47(2):364-366

Dept. of Surgery, Aomori City Hospital.

A 59-year-old man was diagnosed with cholecystolithiasis and cholecystitis and underwent cholecystectomy. The pathological findings were moderately differentiated adenocarcinoma(pT2)in the gallbladder fundus. Sixteen days after surgery, he visited our hospital due to jaundice. Read More

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February 2020

[A Case of Metachronous Liver Metastasis of Gallbladder Cancer Controlled by Liver Resection].

Gan To Kagaku Ryoho 2020 Feb;47(2):361-363

Dept. of Hepato-Biliary-Pancreatic Surgery, Osaka City General Hospital.

The patient was an 81-year-old woman. She had undergone extended cholecystectomy with lymph node dissection for primary gallbladder cancer. The pathological diagnosis was moderately differentiated tubular adenocarcinoma(pT2, N0, M0, pStage Ⅱ). Read More

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February 2020

[A Case of Unresectable Gallbladder Cancer with Relatively Good Prognosis Treated with Upfront Surgery Followed by Systemic Chemotherapy].

Gan To Kagaku Ryoho 2020 Jan;47(1):168-170

Dept. of Surgery, Osaka Rosai Hospital.

A female patient in her 60s was diagnosed with advanced gallbladder cancer invading the hilar plate. Exploratory laparoscopic examination showed limited peritoneal dissemination. Despite endoscopic nasobiliary drainage, it was difficult to treat infectious cholangitis. Read More

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January 2020

Phase I study of DFP-11207, a novel oral fluoropyrimidine with reasonable AUC and low C and improved tolerability, in patients with solid tumors.

Invest New Drugs 2020 May 6. Epub 2020 May 6.

Delta-Fly Pharma, Inc., Tokushima, Japan.

5-fluorouracil (5-FU) and 5-FU derivatives, such as capecitabine, UFT, and S-1, are the mainstay of chemotherapy treatment for gastrointestinal cancers, and other solid tumors. Compared with other cytotoxic chemotherapies, these drugs generally have a favorable safety profile, but hematologic and gastrointestinal toxicities remain common. DFP-11207 is a novel oral cytotoxic agent that combines a 5-FU pro-drug with a reversible DPD inhibitor and a potent inhibitor of OPRT, resulting in enhanced pharmacological activity of 5-FU with decreased gastrointestinal and myelosuppressive toxicities. Read More

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http://dx.doi.org/10.1007/s10637-020-00939-wDOI Listing

C -Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation.

Hepatology 2020 May 6. Epub 2020 May 6.

Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The wide prevalence of chemoresistance and compromised early diagnosis of gallbladder cancer (GBC) has led to poor patient prognosis, requiring sustained efforts for the identification of effective biomarkers and novel therapeutic intervention. Ceramides have emerged as intracellular signaling molecules linked to tumorigenesis and therapeutic response in cancers. However, the clinical relevance of ceramides with gallbladder cancer has not been investigated. Read More

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http://dx.doi.org/10.1002/hep.31304DOI Listing
May 2020
11.055 Impact Factor

NUC-1031/cisplatin versus gemcitabine/cisplatin in untreated locally advanced/metastatic biliary tract cancer (NuTide:121).

Future Oncol 2020 Jun 6;16(16):1069-1081. Epub 2020 May 6.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Gemcitabine/cisplatin is standard of care for first-line treatment of patients with advanced biliary tract cancer (aBTC); new treatments are needed. NUC-1031 is designed to overcome key cancer resistance mechanisms associated with gemcitabine. The tolerability/efficacy signal of NUC-1031/cisplatin in the Phase Ib ABC-08 study suggested that this combination may represent a more efficacious therapy than gemcitabine/cisplatin for patients with aBTC, leading to initiation of the global NuTide:121 study which will include 828 patients ≥18 years with untreated histologically/cytologically-confirmed aBTC (including cholangiocarcinoma, gallbladder or ampullary cancer); randomized (1:1) to NUC-1031 (725 mg/m)/cisplatin (25 mg/m) or gemcitabine (1000 mg/m)/cisplatin (25 mg/m), on days 1/8, Q21-days. Read More

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http://dx.doi.org/10.2217/fon-2020-0247DOI Listing

Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Front Oncol 2020 21;10:536. Epub 2020 Apr 21.

Clinical Cancer Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Comprehensive Genomic Profiling may be informative for novel treatment strategies and to improve outcomes for patients with rare tumors. This study aims to discover opportunities for use of targeted therapies already approved for routine use in patients with rare tumors. Solid tumors with an incidence lower than 2. Read More

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http://dx.doi.org/10.3389/fonc.2020.00536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186305PMC

Liver resection surgery compared with thermal ablation in high surgical risk patients with colorectal liver metastases: the LAVA international RCT.

Health Technol Assess 2020 Apr;24(21):1-38

Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.

Background: Although surgical resection has been considered the only curative option for colorectal liver metastases, thermal ablation has recently been suggested as an alternative curative treatment. There have been no adequately powered trials comparing surgery with thermal ablation.

Objectives: Main objective - to compare the clinical effectiveness and cost-effectiveness of thermal ablation versus liver resection surgery in high surgical risk patients who would be eligible for liver resection. Read More

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http://dx.doi.org/10.3310/hta24210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232132PMC

Gallbladder Neuroendocrine Carcinoma: A Rare Endocrine Tumor.

Cureus 2020 Mar 31;12(3):e7487. Epub 2020 Mar 31.

Internal Medicine, Indiana University Health, Indianapolis, USA.

Gallbladder neuroendocrine neoplasms (GB-NEN) are very rare neuroendocrine tumors (NETs). GB-NEN can present as carcinoid or typical/atypical carcinoid or small cell carcinoma. Most of the GB-NENs present as gall bladder polyps or stones with right upper quadrant pain, nausea and non-specific symptoms which leads to clinical misdiagnosis. Read More

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http://dx.doi.org/10.7759/cureus.7487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192559PMC

Primary Sclerosing Cholangitis: Burden of Disease and Mortality Using Data from the National Rare Diseases Registry in Italy.

Int J Environ Res Public Health 2020 Apr 29;17(9). Epub 2020 Apr 29.

National Center for Rare Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.

Studies on the epidemiology of primary sclerosing cholangitis (PSC) are mainly based on tertiary referral centers; and are retrospective case series susceptible to . The aim of this study was to estimate incidence; survival and cause of mortality of PSC in Italy; using population-based data. Data collected from the National Rare Diseases Registry (RNMR) and the National Mortality Database (NMD) were integrated and analyzed. Read More

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http://dx.doi.org/10.3390/ijerph17093095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246900PMC

FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway.

Front Oncol 2020 17;10:545. Epub 2020 Apr 17.

Department of Biliary Tract Surgery I, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.

Gallbladder cancer (GBC) is one of the most lethal malignancies worldwide, with extremely poor prognosis. Recently, forkhead box k1 (FOXK1), a member of the FOX transcription factor family, has been reported to be correlated with tumor progression in multiple malignancies. However, the role of FOXK1 in GBC has not been elucidated. Read More

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http://dx.doi.org/10.3389/fonc.2020.00545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180204PMC

Epidemiology of HPB malignancy in the elderly.

Eur J Surg Oncol 2020 Apr 19. Epub 2020 Apr 19.

Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.

The incidence of hepatopancreatobiliary (HPB) cancers is increasing worldwide. Despite improvements in cancer surveillance and earlier access to therapy, these cancers still have poor survival rates, especially in elderly patients. There are several challenges in elucidating the epidemiology of these malignancies especially in view of the heterogeneous exposure to recognised risk factors and the coding systems used. Read More

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http://dx.doi.org/10.1016/j.ejso.2020.03.222DOI Listing

Differences in cancer survival by remoteness of residence: an analysis of data from a population-based cancer registry.

Cancer Causes Control 2020 Jul 30;31(7):617-629. Epub 2020 Apr 30.

Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia.

Purpose: Cancer survival is generally lower for rural compared with urban residents, but findings have been inconsistent. We aimed to assess inequalities in cancer survival by remoteness of residence in Victoria, Australia.

Methods: Incident cancer cases diagnosed in 2001-2015 with 30 cancer types (n = 331,302) were identified through the Victorian Cancer Registry and followed to the end of 2015 through death registries. Read More

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http://dx.doi.org/10.1007/s10552-020-01303-2DOI Listing

HER2 Overexpression as a Poor Prognostic Determinant in Resected Biliary Tract Cancer.

Oncologist 2020 Apr 30. Epub 2020 Apr 30.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Background: HER2 overexpression has been investigated as a potential biomarker and therapeutic target in biliary tract cancer (BTC), but a prognostic role of such alteration has not been demonstrated yet.

Materials And Methods: We retrospectively evaluated HER2 protein expression by immunohistochemistry (IHC) in 100 patients with radically resected BTC. HER2 gene amplification was assessed by fluorescence in situ hybridization (FISH) in 2+ and 3+ cases at IHC. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0922DOI Listing

Meta-analysis of randomized clinical trials of adjuvant chemotherapy for resected biliary tract cancers.

HPB (Oxford) 2020 Apr 26. Epub 2020 Apr 26.

Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Background: This meta-analysis was performed by analyzing randomized controlled trials (RCTs) to assess the potential prognostic value of adjuvant chemotherapy (ACT) for patients with resected biliary tract cancers (BTCs).

Methods: PubMed, EMBASE, and the Cochrane Library were searched for relevant articles published. Only RCTs affected by tumors of gallbladder, intrahepatic, perihilar, and distal bile ducts were considered. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.02.001DOI Listing