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Turk J Gastroenterol 2021 Feb;32(2):218-224

Department of General Surgery, Gazi University School of Medicine, Ankara, Turkey.

Background: Selective versus routine histopathological examination after cholecystectomy is still in debate. This study aims to investigate the effect of histopathology results on treatment modality and surgery strategy. The validity of the selective histopathology approach was questioned. Read More

Medwave 2021 Apr 9;21(3):e8045. Epub 2021 Apr 9.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Hemato-Oncología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Gallbladder cancer is the most common malignancy of the biliary tract. Given the lack of therapeutic alternatives for advanced stage patients studies have suggested that palliative chemotherapy could benefit these patients.

Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. Read More

Cardiovasc Intervent Radiol 2021 May 4. Epub 2021 May 4.

Division of Image Guided Minimally Invasive Surgery, Juan D. Perón 4190 (C1181ACH), Ciudad autónoma de Buenos Aires, Argentina.

Purpose: The aim of this study was to determine the effect of hyperbilirubinemia in the sensitivity of percutaneous transluminal forceps biopsy (PTFB) in patients with suspected malignant biliary stricture.

Materials And Methods: Ninety-three patients with suspicion of malignant biliary stricture underwent percutaneous transhepatic cholangiography followed by PTFB. Sensitivity, specificity and predictive values were analysed based on the presence or absence of hyperbilirubinemia, defined as total bilirubin equal to, or higher than 5 mg/dL. Read More

Am J Case Rep 2021 May 4;22:e929511. Epub 2021 May 4.

General Surgery Division, Hospital das Clínicas at Federal University of Pernambuco (HC/UFPE), Recife, PE, Brazil.

BACKGROUND Mixed adenoneuroendocrine carcinoma of the gallbladder (gMANEC) is an extremely rare cancer. Most of the cases are reported in Asia, North America, and Europe, with no cases reported in Latin America; this is the first report for this region, and the 24th case reported worldwide. CASE REPORT A 68-year-old woman was referred to our department due to asthenia and moderate abdominal pain in the right upper quadrant for 6 months, with imaging examinations showing a solid heterogeneous expansive lesion in gallbladder topography and segment IV of the liver. Read More

Hepatology 2021 May 3. Epub 2021 May 3.

Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Background & Aims: Biliary tract cancer (BTC) is rare and has limited treatment options. We aimed to examine aspirin use on cancer-specific survival in various biliary tract cancer (BTC) subtypes, including gallbladder cancer, ampulla of Vater cancer, and cholangiocarcinoma.

Approach & Results: Nationwide prospective cohort of newly diagnosed BTC between 2007 and 2015 were included and followed until December 31, 2017. Read More

Ann Surg Oncol 2021 May 3. Epub 2021 May 3.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Radiol Case Rep 2021 Jun 15;16(6):1477-1484. Epub 2021 Apr 15.

Department of Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA.

Chronic lymphocytic leukemia (CLL) is the second most common hematologic malignancy, and it is characterized by lymphocytic leukocytosis and secondary hematologic deficiencies. While it most commonly presents as a systemic disease, extramedullary involvement may rarely occur. The literature surrounding CLL metastatic disease to the gallbladder is particularly sparse. Read More

J Cytol 2021 Jan-Mar;38(1):8-13. Epub 2021 Jan 8.

Department of Pathology, Dong-A University College of Medicine, Busan, Korea.

Context: Subtyping of solitary pulmonary lesion (SPL) in small amount of cytology specimen using a limited panel of immunohistochemistry (IHC) markers is very important to the correct choice of treatment. This study was performed to categorize non-small cell carcinoma-not otherwise specified (NSCC-NOS) on cytology in patients with SPL, especially with regard to the incidence of metastatic cancer.

Materials And Methods: We reviewed 91 cases, in which a precise morphology-based, lineage-specific IHC-aided subtyping was not possible, that qualified as NSCC-NOS on cytology. Read More

Am J Gastroenterol 2021 May;116(5):1053-1062

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.

Introduction: Recent trends in the incidence and mortality of biliary tract cancers are unknown. We estimated the trends in biliary tract cancers-related incidence and mortality stratified by anatomical site, age, sex, and race/ethnicity in the US adults.

Methods: We performed a population-based trend analysis using the US national incidence (2009-2017) and mortality records (2009-2018). Read More

Cancers (Basel) 2021 Apr 2;13(7). Epub 2021 Apr 2.

Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Inhibition of the programmed cell death protein-1/ligand-1 (PD-1/PD-L1) axis has opened a new era in the treatment of solid cancers. However, there is no data on the expression and relevance of PD-L1 in Western gallbladder cancer (GBC). We assessed PD-L1 immunohistochemically in 131 GBC patients as Tumor Proportion Score (TPS), Immune Cell Score (IC) and Combined Positivity Score (CPS). Read More

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, Korea.

Biliary tract cancers (BTCs) are a group of aggressive malignancies that arise from the bile duct and gallbladder. BTCs include intrahepatic cholangiocarcinoma (IH-CCA), extrahepatic cholangiocarcinoma (EH-CCA), and gallbladder cancer (GBCA). BTCs are highly heterogeneous cancers in terms of anatomical, clinical, and pathological characteristics. Read More

Pan Afr Med J 2021 9;38:144. Epub 2021 Feb 9.

Service de Chirurgie Viscérale et Oncologie Digestive A, Centre Hospitalier Universitaire Mohammed VI, Oujda, Maroc.

Congenital cystic disease of the biliary tree is a known risk factor for gallbladder cancer. We here report a case of squamous cell carcinoma of the bile duct (BD) complicating a cystic dilatation of the bile ducts in a 54-year-old woman hospitalized for biliary pancreatitis. Abdominal scanner showed nodular thickening of the fundus of the gallbladder and fusiform dilation of the cystic duct and the main bile duct (VBP) with lesion of the tail of the pancreas, initially suggesting mucinous cystadenoma. Read More

Onco Targets Ther 2021 22;14:2815-2819. Epub 2021 Apr 22.

Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Gallbladder cancer is a highly aggressive malignancy with an extremely poor prognosis. Germline mutation in gallbladder cancer is very rare. Herein, we present a case of a 73-year-old Asian patient diagnosed with lymph nodes and peritoneal metastases just two months after surgery for primary gallbladder cancer. Read More

Zhonghua Yi Xue Za Zhi 2021 Apr;101(16):1154-1159

Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China.

To describe the clinical manifestations, neuroimaging, cerebrospinal fluid(CSF) cytology and prognosis of Leptomeningeal metastases(LM). The clinical manifestations, imaging features and CSF cytology of LM patients admitted to Henan Provincial People's Hospital from May 1, 2015 to May 31, 2020 were retrospectively analyzed. The overall survival (OS) was evaluated by the time from the diagnosis of LM to death. Read More

Cancer Treat Res Commun 2021 Apr 9;27:100370. Epub 2021 Apr 9.

Hirotsu Bio Science Inc., New Otani Garden Court 22F, 4-1 Kioi-cho, Chiyoda-ku, Tokyo, 102-0094, Japan. Electronic address:

Early cancer detection is critical for effective treatment. N-NOSE (Nematode-NOSE) is a simple, inexpensive, and highly sensitive cancer screening method based on the chemotaxis of the nematode Caenorhabditis elegans, which shows evasive action from the urine of healthy individuals while being attracted to the urine of cancer patients. Initially, N-NOSE relied on chemotaxis indexes obtained with 10-fold dilutions of urine samples. Read More

Int J Cancer 2021 Apr 25. Epub 2021 Apr 25.

Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Read More

Hepatobiliary Surg Nutr 2021 Apr;10(2):210-225

Hepatobiliary Surgery and Organ Transplantation Unit, Department of General Surgery and Organ Transplantation, Sapienza University of Rome, Rome, Italy.

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) represents an innovative surgical technique used for the treatment of large hepatic lesions at high risk for post-resection liver failure due to a small future liver remnant. The most significant amount of literature concerns the use of ALPPS for the treatment of hepatocellular carcinoma (HCC), cholangiocarcinoma (CCC), and colorectal liver metastases (CRLM). On the opposite, few is known about the role of ALPPS for the treatment of uncommon liver pathologies. Read More

Oncologist 2021 Apr 25. Epub 2021 Apr 25.

Division of Hematology and Oncology, Columbia University Irving Medical Center, and New York Presbyterian Hospital, Herbert Irving Pavilion, 161 Fort Washington Avenue, New York, NY, USA.

HER2 amplification, which results in overexpression of the receptor tyrosine kinase HER2, has been described in a wide variety of malignancies. HER2-targeting agents have been incorporated into the treatment paradigms for HER2-overexpressing breast and gastric cancer. More recently, these agents have shown promise in other gastrointestinal malignancies, such as colon cancer and biliary tract tumors. Read More

Asian J Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. Electronic address:

Previous studies have explored the role of laparoscopic surgery (LS) in the surgical management of gallbladder carcinoma (GBC) and obtained satisfactory outcomes versus conventional open surgery. However, most of them either included a small number of patients or mainly focused on the early-staged lesions. Therefore, their results were less statistical powerful and a more comprehensive evaluation on the role of LS in GBC is warranted. Read More

Eur J Cancer 2021 Apr 20;150:73-82. Epub 2021 Apr 20.

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea. Electronic address:

Aims: The association between non-alcoholic fatty liver disease (NAFLD) and cholangiocarcinoma has been previously reported only in case-control studies. Therefore, we conducted this nationwide cohort study to evaluate the longitudinal association between NAFLD and the risk of biliary tract cancer (BTC), including cholangiocarcinoma and gallbladder cancer.

Methods: We included 8,120,674 adults who underwent national health screening in 2009 based on the Korean National Health Insurance Service data. Read More

Int J Gen Med 2021 16;14:1325-1335. Epub 2021 Apr 16.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Background: Based on the admission data, we applied the XGBoost algorithm to create a prediction model to estimate the AKI risk in patients with hepatobiliary malignancies and then compare its prediction capacity with the logistic model.

Methods: We reviewed clinical data of 7968 and 589 liver/gallbladder cancer patients admitted to Zhongshan Hospital during 2014 and 2015. They were randomly divided into the training set and test set. Read More

Trans R Soc Trop Med Hyg 2021 Apr 22. Epub 2021 Apr 22.

Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka.

Background: Ultrasound (US) is an investigation available in many acute care settings. Thrombocytopenia is a well-described complication of dengue infection and has been shown to correlate with disease severity. The purpose of this study was to assess the utility of admission ultrasonography in predicting thrombocytopenia and disease severity in patients infected with dengue virus. Read More

Hepatology 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background & Aims: Biliary tract cancer (BTC) exhibits diverse molecular characteristics. However, reliable biomarkers that predict therapeutic responses are yet to be discovered. We aimed to identify the molecular features of treatment responses to chemotherapy and immunotherapy in BTCs. Read More

Medicine (Baltimore) 2021 Apr;100(16):e25466

Department of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.

Rationale: Endoscopic ultrasonography-guided tissue acquisition (EUS-TA) has become the norm for the diagnosis of pancreatic solid lesions. EUS-TA is relatively safe, but various complications can occur. Infected pancreatic necrosis (IPN) is a rare but serious complication. Read More

BMC Cancer 2021 Apr 20;21(1):433. Epub 2021 Apr 20.

Department of General Surgery, the Armed Police Corps Hospital of Anhui, Hefei, 230041, People's Republic of China.

Background: Inositol polyphosphate 4-phosphatase type II (INPP4B) is a negative regulator of the PI3K-Akt signalling pathway and plays a contradictory role in different types of cancers. However, the its biological role played by INPP4B in human gallbladder cancer (GBC) has not been elucidated. In this study, we investigated the expression, clinical significance and biological function of INPP4B in GBC patients and cell lines. Read More

Expert Rev Gastroenterol Hepatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Abdominal Cancer, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.

Introduction: Gallbladder carcinosarcoma (GBCS) is a rare neoplasm, and previous studies regarding to GBCS were case reports/case series, absence of large retrospective analyses or systemic review. This review summarizes the current literature on accurate information of GBCS to assist clinicians to accurately diagnose and treat this malignancy.

Areas Covered: The authors retrieved relevant documents of GBCS from PubMed and Medline. Read More

J Korean Med Sci 2021 Apr 19;36(15):e94. Epub 2021 Apr 19.

Hecto Innovation Lab., Hecto Co., Ltd., Seoul, Korea.

Background: Common bile duct (CBD) stone is one of the most prevalent gastroenterological diseases, but the role played by biliary microbiota in the pathogenesis of CBD stones remains obscure. The aim of this study was to investigate the characteristics of the biliary tract core microbiome and its potential association with the formation of pigment stones.

Methods: Twenty-eight patients with biliary obstruction of various causes were enrolled. Read More

J Surg Res 2021 Apr 16;265:27-32. Epub 2021 Apr 16.

The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire.

Background: At any given time, almost 2 million individuals are in prisons or jails in the United States. Incarceration status has been associated with disproportionate rates of cancer and infectious diseases. However, little is known about the burden emergency general surgery (EGS) in criminal justice involved (CJI) populations. Read More

Cancer Lett 2021 Apr 16;510:93-104. Epub 2021 Apr 16.

Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, 200127, China; Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, 200092, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai, 200127, China; Shanghai Research Center of Biliary Tract Disease, Shanghai, 200092, China. Electronic address:

Dysfunction of Sirtuin 3 (SIRT3), an NAD-dependent histone deacetylase, impairs varied mitochondrial metabolic pathways in human cancer. Here, we explored suppressive activity of SIRT3 in the progression of gallbladder cancer (GBC). Expression levels of SIRT3 in patients with GBC were lower than those in the adjacent normal tissue. Read More

ACS Appl Mater Interfaces 2021 Apr 19;13(16):18462-18471. Epub 2021 Apr 19.

College of Chemistry and Chemical Engineering, Henan Province Key Laboratory of Utilization of Non-metallic Mineral in the South of Henan, Xinyang Normal University, Xinyang 464000, P. R. China.

Engineered magnetic nanoparticles have been extensively explored for magnetic resonance imaging (MRI) diagnosis of a tumor to improve the visibility. However, most of these nanoparticles display "always-on" signals without tumor specificity, causing insufficient contrast and false positives. Here, we provide a new paradigm of MRI diagnosis using MnCO nanorhombohedras (MnNRs) as an ultrasensitive -weighted MRI contrast agent, which smartly enhances the MR signal in response to the tumor microenvironment. Read More