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Front Oncol 2022 2;12:833447. Epub 2022 May 2.

Department of Abdominal Cancer, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.

Background: Gallbladder squamous cell carcinoma (GSCC) is a rare carcinoma with limited evidence in literature, making it particularly difficult to study. Surveillance, Epidemiology, and End Results Database (SEER) were used to stress the clinicopathological features and outcomes associated with this tumor.

Methods: SEER registries were used to identify GSCC and gallbladder adenocarcinoma (GAC) cases from 2004 to 2015. Read More

Int Arch Occup Environ Health 2022 May 19. Epub 2022 May 19.

Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.

Background: Three industrial waste incinerators (IWIs) were built in 1999, 2001, and 2010, within a 3 km radius of a town with a population of around 5000 in Korea. This study evaluated whether residents near these three IWIs had increased cancer incidence than those from other areas in Korea using regional health data.

Methods: Standardized incidence ratios (SIR) were calculated using the frequency of cancer cases in the National Cancer Registry of the exposed area (Buki-myeon), Chungcheongbuk-do (Chungbuk, state including Buki-myeon), and whole Korea from 1999 to 2017. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):664-669

University of Health Sciences Turkey, Haydarpasa Numune Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.

Objective: This study aimed to examine the prognostic effect of the tumor-stroma ratio, which has been shown to have prognostic value in various cancers, in patients with gallbladder cancer who have undergone curative resection.

Methods: The records of gallbladder cancer patients who underwent surgical treatment in our clinic between December 2005 and March 2021 were analyzed retrospectively. The hematoxylin and eosin-stained sections representing the tumors were evaluated under light microscopy to determine tumor-stroma ratio, and based on the results, <50% was defined as the stroma-rich and ≥50% as the stroma-poor groups. Read More

Abdom Radiol (NY) 2022 May 18. Epub 2022 May 18.

Department of Radiology, Kingston Health Sciences Centre, Queen's University, Kingston, ON, Canada.

Purpose: To assess the diagnostic performance of quantitative and qualitative imaging features of hepatic cirrhosis on CT.

Methods: A single-center retrospective cohort study was performed on all patients who had undergone non-targeted liver biopsy < 3 months following abdominal CT imaging between 2007 and 2020. Histopathology was required as a reference standard for hepatic cirrhosis diagnosis. Read More

Cell Death Discov 2022 May 17;8(1):265. Epub 2022 May 17.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Gallbladder cancer is the most common biliary tract malignant tumor with highly metastatic characters and poor prognosis. However, the underlying mechanism remains unclear. Stathmin1 is ubiquitous phosphoprotein, regulating microtubule stabilization. Read More

Curr Mol Med 2022 May 9. Epub 2022 May 9.

Department of Mesenchymal Stem Cells, Academic Center for Education, Culture and Research (ACECR), Qom Branch, Qom, Iran.

Long noncoding RNAs (lncRNAs) are prominent as crucial regulators of tumor establishment and are repeatedly dysregulated in multiple cancers. Therefore, lncRNAs have been identified to play an essential function in carcinogenesis and progression of cancer at genetic and epigenetic levels. FENDRR (fetal-lethal noncoding developmental regulatory RNA) as an LncRNA is a hallmark of various malignancies. Read More

J Surg Oncol 2022 May 16. Epub 2022 May 16.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: As minimally invasive surgery (MIS) approaches to biliary tract cancers become more commonplace, understanding the adequacy of their oncologic performance is key.

Methods: The National Cancer Database 2010-2016 was queried for patients who underwent hepatectomy for intrahepatic cholangiocarcinoma (IHC) and T1b or more advanced gallbladder cancer (GBC). Patients were grouped by approach: open (OA), laparoscopic (LA), and robotic (RA). Read More

Radiol Case Rep 2022 Jul 5;17(7):2309-2314. Epub 2022 May 5.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

A 72-year-old female without abdominal symptoms visited our hospital for routine follow-up while undergoing pancreatic cancer treatment (using TS-1). Her vital signs were normal, and her abdomen was soft and non-tender. Blood test revealed elevated C-reactive protein levels with normal white blood cell count. Read More

J Clin Med 2022 May 8;11(9). Epub 2022 May 8.

Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, 79, Gangnam-ro, Jinju 52727, Korea.

Although laparoscopic treatment for T1 gallbladder cancer (GBC) has been described previously, the differences in oncologic outcomes between laparoscopic and conventional open surgery for T2 GBC have not been investigated. We aimed to assess the role of laparoscopic surgery using retrospectively collected data for 81 patients with T2 GBC who underwent surgical resection between January 2010 and December 2017. Eligible patients were classified into "laparoscopic" and "open" groups. Read More

J Surg Case Rep 2022 May 6;2022(5):rjac202. Epub 2022 May 6.

Anne Arundel Medical Center at Luminis Health, Department of Surgery, 2003 Medical Parkway, Suite 301, Annapolis, 21401.

Gallbladder adenocarcinoma is a rare gastrointestinal malignancy and is associated with a poor prognosis. These malignancies are most often discovered incidentally in [Formula: see text]1% of all cholecystectomy procedures. We report an 80-year-old male patient with iron deficiency anemia, who underwent an unremarkable endoscopy and colonoscopy, and was subsequently found to have hemobilia discovered on capsule endoscopy. Read More

J Gastrointest Oncol 2022 Apr;13(2):822-832

Department of Neurosurgery, Stanford University Medical Center, Stanford, CA, USA.

Background: Biliary cancers are rare, and few reported cases of brain metastases from primary biliary cancers exist, especially describing patients in the United States. This report assesses the proportion and incidence of brain metastases arising from primary biliary cancers [cholangiocarcinoma (CCA) and gallbladder cancer] at Stanford University and the University of California, San Francisco, describes clinical characteristics, and provides a case series.

Methods: We queried 3 clinical databases at Stanford and the University of California, San Francisco to retrospectively identify and review the charts of 15 patients with brain metastases from primary biliary cancers occurring between 1990 to 2020. Read More

Virchows Arch 2022 May 13. Epub 2022 May 13.

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 12800, Prague 2, Czech Republic.

We assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from the gastrointestinal tract (GIT) and the significance of CK17 expression in a broad spectrum of primary ovarian tumors with respect to their prognosis. The sample set consisted of 554 primary ovarian tumors and 255 GIT tumors. In the primary ovarian tumors, a higher CK17 expression (in > 10% of tumors cells) was present only in 0-11. Read More

BMJ Case Rep 2022 May 12;15(5). Epub 2022 May 12.

Hematology/Oncology, Feist-Weiller Cancer Center, Shreveport, Louisiana, USA.

Zhongguo Zhong Yao Za Zhi 2022 Apr;47(7):1739-1753

China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Nanning 530200, China Guangxi Key Laboratory of Traditional Chinese Medicine Rheumatism Prescription Theory and Transformation Nanning 530200, China Guangxi Scientific Research Center of Traditional Chinese Medicine Nanning 530200, China.

Curcuma kwangsiensis root tuber is a widely used genuine medicinal material in Guangxi, with the main active components of terpenoids and curcumins. It has the effects of promoting blood circulation to relieve pain, moving Qi to relieve depression, clearing heart and cooling blood, promoting gallbladder function and anti-icterus. Modern research has proved its functions in liver protection, anti-tumor, anti-oxidation, blood lipid reduction and immunosuppression. Read More

Hepatol Int 2022 May 9. Epub 2022 May 9.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University Medical College, Seoul, Korea.

Background And Purpose: The benefits of adjuvant radiotherapy (ART) in gallbladder cancer (GBC) treatment remain inconclusive owing to the rarity of GBC and lack of randomized studies.

Methods: PubMed, Medline, Embase, and Cochrane Library were systematically searched until March 2021. The primary endpoint was overall survival (OS). Read More

Indian J Med Res 2021 May;154(5):699-706

Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background & Objectives: A high incidence of gallbladder cancer (GBC) is observed in northern India. This study was aimed to identify the factors involved in developing GBC in this region.

Methods: A gallstones-matched, case-control study was conducted in northern India. Read More

Surg Case Rep 2022 May 7;8(1):88. Epub 2022 May 7.

Department of Surgery, Matsuyama Red Cross Hospital, 1, Bunkyo-cho, Matsuyama, Ehime, 790-8524, Japan.

Background: Gastric cancer rarely metastasizes to the gallbladder. Furthermore, there has never been a case report of simultaneous gallbladder metastasis from residual gastric cancer. Here, we report a case of synchronous gallbladder metastasis originating from a residual gastric cancer. Read More

Gut Liver 2022 May;16(3):465-473

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background/aims: Contradictory findings on the association between cholecystectomy and cancer have been reported. We aimed to investigate the risk of all types of cancers or site-specific cancers in patients who underwent cholecystectomy using a nationwide dataset.

Methods: Subjects who underwent cholecystectomy from January 1, 2007, to December 31, 2014, who were older than 20 years and who underwent an initial baseline health check-up within 2 years were enrolled. Read More

Ann Med Surg (Lond) 2022 Apr 28;76:103514. Epub 2022 Mar 28.

Department of Pathology, Tishreen University Hospital, Lattakia, Syria.

Introduction And Importance: Malignant melanoma is one of the most aggressive unpredictable tumors that can metastasize to any organ. Metastases from cutaneous melanoma to the gallbladder are exceedingly rare. Most patients with gallbladder metastases from malignant melanoma are usually asymptomatic; therefore, its diagnosis can be a real challenge. Read More

Front Oncol 2022 14;12:889334. Epub 2022 Apr 14.

Department of Hepatopancreatobiliary, Third Affiliated Hospital of Soochow University, Changzhou, China.

Aims: To investigate the clinical efficacy and prognostic factors of primary gallbladder cancer (GBC) treated by radical surgery.

Methods: The clinical and pathological data of 168 patients with primary gallbladder cancer admitted and treated in the Third Affiliated Hospital of Soochow University from January 1st, 2010 to December 31st, 2018 were analyzed retrospectively. Kaplan Meier method was used to draw the survival curve and evaluate the survival rate. Read More

Eur J Cancer Prev 2022 Apr 26. Epub 2022 Apr 26.

Division of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University, Suita Osaka, Japan.

Objective: The epidemiologic features of each biliary tract cancer (BTC) subtype have not been studied and disclosed in detail. The objective of this study was to provide an up-to-date description of the epidemiologic features of BTC by subtypes, especially in terms of the geographic variation of its incidence.

Methods: We calculated the age-standardized incidence rate (ASR) of each BTC subtype at national and prefectural levels using the data from the national cancer registry in 2016 and 2017. Read More

J Transl Med 2022 04 28;20(1):188. Epub 2022 Apr 28.

Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.

Background: Recent studies exploring the roles of invasion-metastasis associated miRNAs in gallbladder cancer (GBC) are limited. In the study, we aimed to identify the invasion-metastasis associated miRNAs in GBC by bioinformatics and experimental validation.

Methods: MiRNAs of different expression were identified by comparing GBC tumor samples with different survival from Gene Expression Omnibus database. Read More

Am J Surg 2022 Apr 23. Epub 2022 Apr 23.

Department of Surgery, Mount Sinai South Nassau, Oceanside, NY, USA; Department of Surgery, Division of HPB Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Background: Although gallbladder cancer is the most common biliary tract malignancy, squamous cell carcinoma of the gallbladder (GBSCC) is extremely uncommon, comprising approximately 1-4% of all malignant gallbladder tumors. Given its rare incidence, there are currently no established treatment guidelines for GBSCC.

Methods: We reviewed the current data available through a comprehensive search of PubMed/MEDLINE and Embase. Read More

Pathologica 2022 Apr;114(2):138-145

Department of Histopathology, Berkshire Surrey Pathology Services, Royal Surrey County Hospital, Guildford, UK.

Objective: To identify and compare significant or relevant prognostic factors in pre-operatively diagnosed, surgically resectable, gallbladder cancer and in incidentally detected gallbladder cancer cases.

Material And Methods: Gallbladder resections (October 2009-March 2016) were identified on the histopathology Winpath database. Cases with a final histological diagnosis of gallbladder cancer (GBC) were categorised into: Group A: clinically suspected operable GBC (n = 13). Read More

Med Oncol 2022 Apr 28;39(5):64. Epub 2022 Apr 28.

Department of General Surgery, Central Hospital of Xuhui District, Shanghai, People's Republic of China.

Genomic instability and mutability are a prominent character of tumor. The whole-exosome sequence reveals that ERBB2 mutations are the representative mutations of gallbladder carcinoma, which takes potential targets for gallbladder carcinoma therapy. However, the roles of ERBB2 mutations are unclear in gallbladder carcinoma. Read More

Ann Surg Treat Res 2022 Apr 5;102(4):185-192. Epub 2022 Apr 5.

Department of Surgical Oncology, Hatay Training and Research Hospital, Hatay, Turkey.

Purpose: Cholecystectomy is one of the most common surgeries today due to gallbladder diseases. The most prevalent malignancy of the biliary tract is gallbladder cancer. We aimed to discuss the results of our patients who underwent cholecystectomy for benign reasons in our clinic and who had gallbladder cancer due to pathology. Read More

Mol Biol Rep 2022 Apr 25. Epub 2022 Apr 25.

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, 221 005, Varanasi, India.

Background: Gallbladder cancer (GBC) represents a wide geographical diversity as well as heterogeneity in clinical and genomic landscape. There seems to be little progress in the development of diagnostic biomarkers, targeted therapies or individualized approaches to GBC management. In this study, we investigated the whole transcriptome profile of GBC patients using RNA sequencing and identified key genes and pathways associated with gallbladder cancer using bioinformatics. Read More

J Clin Med 2022 Apr 11;11(8). Epub 2022 Apr 11.

Department of Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Korea.

Laparoscopic surgery has been traditionally contraindicated for gallbladder cancer, but there have been few reports demonstrating the oncologic outcomes of this treatment. This study aimed to compare the technical feasibility and the long-term outcomes after laparoscopic versus open extended cholecystectomy for gallbladder cancer. Between January 2011 and December 2018, 44 patients with gallbladder cancer who underwent extended cholecystectomy were included in this study, with 20 patients in the laparoscopic group and 24 patients in the open group. Read More

Cancers (Basel) 2022 Apr 12;14(8). Epub 2022 Apr 12.

Center for Primary Health Care Research, Lund University, 205 02 Malmö, Sweden.

We used the Swedish Cancer Registry data to address familial risks for concordant (same) and discordant (different) hepatobiliary cancers, including their associations with any other cancers and with known risk factors. Risks were also assessed between spouses. The analysis covered Swedish families and their cancers between years 1958 and 2018. Read More