43,813 results match your criteria Gallbladder


A cholesterosis of the common bile duct successfully diagnosed macroscopically and histologically using the transpapillary approach.

Dig Endosc 2020 Jul 11. Epub 2020 Jul 11.

Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Cholesterosis is defined as the aggregation of foamy cells under the mucosa [1]. Although cholesterosis of the gallbladder is a common disease, cholesterosis of the common bile duct (CBD) is rare, with only <40 cases reported [2], and diagnosis is extremely difficult [3]. Since cholesterosis is basically a benign tumor, a direct visual examination and histopathological diagnosis is important to reduce unnecessary surgery [4], and endoscopic retrograde cholangiopancreatography (ERCP) and its related procedure have great benefits for patients because of its less-invasiveness and simplicity. Read More

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http://dx.doi.org/10.1111/den.13790DOI Listing

Prognostic impact of tumor location in resected gallbladder cancer: A national cohort analysis.

J Surg Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, City of Hope National Medical Center, Duarte, California.

Background And Objectives: Tumor location (peritoneal vs hepatic) has been incorporated in the 8th edition of the American Joint Committee on Cancer Staging system for gallbladder cancer. However, larger studies are needed to confirm the prognostic impact of tumor location.

Methods: Patients with pathologically-confirmed gallbladder cancer with information on primary tumor location were included from the National Cancer Database (2009-2012). Read More

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http://dx.doi.org/10.1002/jso.26107DOI Listing

Association of Common Single Nucleotide Polymorphisms of Candidate Genes with Gallstone Disease: A Meta-Analysis.

Indian J Clin Biochem 2020 Jul 15;35(3):290-311. Epub 2019 May 15.

Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, UP India.

Numerous studies have investigated the relationship between various candidate gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of common ABCG8 T400K, ABCG8 D19H, ABCG8 C54Y, ApoB100 EcoRI, ApoB100 XbaI, ApoE HhaI, CETP TaqI, CYP7A1 Bsa, LRPAP1 I/D and TNF-α A308G polymorphisms on the risk of gallbladder stone disease. 33 Full-text articles with 9250 cases and 12,029 healthy controls (total 21,279 subjects) were analyzed using the RevMan software (V5. Read More

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http://dx.doi.org/10.1007/s12291-019-00832-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326838PMC

Adeno-squamous and squamous cell carcinoma of the gallbladder: The importance of histology in surgical management.

Am J Surg 2020 Jul 1. Epub 2020 Jul 1.

Division of Surgical Oncology, Icahn School of Medicine at Mount Sinai St. Luke's Roosevelt Hospital, 425 West 59th Street, Suite 7B, New York, NY, 10019, United States.

Background: Although gallbladder adenocarcinoma (AC) is potentially curable with resection, outcomes of squamous histologies are poorly described.

Methods: We retrospectively analyzed all gallbladder cancers which underwent resection-for-cure in our health system from 2007 to 2017. We compared outcomes of AC to adeno-squamous (ASC)/squamous (SC) histologies. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.06.050DOI Listing

Efficacy of Thiol disulfide Homeostasis and Ischemia Modified Albumin Values in Estimating the Degree of Difficulty for Laparoscopic Cholecystectomy.

Comb Chem High Throughput Screen 2020 Jul 9. Epub 2020 Jul 9.

Yildirim Beyazit University Faculty of Medicine, Biochemistry Department, Ankara. Turkey.

Aim: The aim of this study is to investigate the efficacy of thiol disulfide homeostasis and Ischemia Modified Albumin (IMA) values in predicting the technical difficulties that might be encountered during laparoscopic cholecystectomy.

Materials And Methods: The study included 65 patients who underwent laparoscopic cholecystectomy due to cholelithiasis at the General Surgery Clinic of Ankara Numune Training and Research Hospital. All patients' demographic data, previous history of cholecystitis, a history of chronic illness, preoperative white blood count (WBC), liver function tests (AST, ALT), amylase and lipase levels, intra-operative adhesion score, the ultrasonographic appearance of gallbladder, duration on hospital stay, duration of operation, thiol disulfide and IMA values were evaluated. Read More

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http://dx.doi.org/10.2174/1386207323666200709165910DOI Listing

Fetus of 8q22.2q24.3 duplication and 13q33.2q34 deletion derived from a maternal balanced translocation.

J Obstet Gynaecol Res 2020 Jul 8. Epub 2020 Jul 8.

Department of Prenatal Diagnosis Medical Center, XuZhou Central Hospital, XuZhou Clinical School of Xuzhou Medical University, Jiangsu, China.

The concomitant occurrence of 8q duplication and 13q deletion is the first to be detected by noninvasive prenatal testing (NIPT) to date. Through case analysis, we could provide a clinical approach to pregnant women with chromosomal abnormalities revealed by NIPT. The combination of traditional karyotype and copy number variation sequencing (CNV-seq) could better locate the abnormal chromosomal region and further identify the source of fetal chromosomal abnormalities. Read More

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http://dx.doi.org/10.1111/jog.14386DOI Listing

A case of mixed neuroendocrine non-neuroendocrine neoplasm of the distal bile duct with biliary intraepithelial neoplasia.

Clin J Gastroenterol 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastroenterology and Hepatology, Yamaguchi Rosai Hospital, 1315-4 Onoda, Sanyo-Onoda, Yamaguchi, 756-0095, Japan.

A 72-year-old man with obstructive jaundice, diagnosed with distal biliary carcinoma, underwent pylorus-preserving pancreaticoduodenectomy. The patient was histopathologically and immunohistochemically diagnosed with mixed neuroendocrine non-neuroendocrine neoplasm. Pathological examination revealed that the well-differentiated adenocarcinoma components occupied the superficial portion of the bile duct and the neuroendocrine carcinoma components were located in the deeper portion of the bile duct. Read More

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http://dx.doi.org/10.1007/s12328-020-01174-9DOI Listing

Efficacy and safety of endoscopic laser lithotripsy and lithotomy through the lumen-apposing metal stent for giant gallbladder stones.

VideoGIE 2020 Jul 7;5(7):318-323. Epub 2020 May 7.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.

Background And Aims: EUS-guided gallbladder drainage has been increasingly applied for acute cholecystitis in high-risk surgical patients. In cases of EUS-guided gallbladder drainage with lumen-apposing metal stents (LAMSs), endoscopic retrieval of gallstones becomes feasible. However, retrieval of giant gallstones is still difficult because of the limited space in the saddle section of the LAMS. Read More

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http://dx.doi.org/10.1016/j.vgie.2020.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332785PMC

Endoscopic transpapillary gallbladder stent placement in the presence of uncovered biliary metal stents using a through-the-mesh technique.

VideoGIE 2020 Jul 15;5(7):296-299. Epub 2020 May 15.

Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki, Japan.

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http://dx.doi.org/10.1016/j.vgie.2020.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332764PMC

Safe, selective histopathological examination of gallbladder specimens: a systematic review.

Br J Surg 2020 Jul 8. Epub 2020 Jul 8.

Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

Background: Routine histopathological examination after cholecystectomy is costly, but the prevalence of unsuspected gallbladder cancer (incidental GBC) is low. This study determined whether selective histopathological examination is safe.

Methods: A comprehensive search of PubMed, Embase, Web of Science and the Cochrane Library was performed. Read More

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http://dx.doi.org/10.1002/bjs.11759DOI Listing

Routine histopathological examination of gallbladder specimens after cholecystectomy: Is it time to change the current practice?

Authors:
Banu Karapolat

Turk J Surg 2020 Mar 18;36(1):117-118. Epub 2020 Mar 18.

Clinic of General Surgery, Kanuni Training and Research Hospital, Trabzon, Turkey.

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http://dx.doi.org/10.5578/turkjsurg.4409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315443PMC

Gallbladder schistosomiasis - a rare presentation as gallbladder polyp: a case report.

Radiol Case Rep 2020 Aug 29;15(8):1394-1397. Epub 2020 Jun 29.

Department of Radiology, Nepalgunj Medical College and Teaching Hospital, Kohalpur, Banke 21904, Nepal.

Schistosomiasis is a neglected tropical disease second to malaria in prevalence with significant morbidity and mortality. Although, Schistosomiasis can affect multiple organs, gallbladder involvement is very rarely reported. We present a case of isolated gallbladder schistosomiasis in a 20-year-old female presenting as gallbladder polyp radiologically and also correlated the histopathological findings which to our knowledge has never been reported in the English literature. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329932PMC

Innovation of EUS-guided transmural gallbladder drainage using a novel self-expanding metal stent.

Sci Rep 2020 Jul 7;10(1):11159. Epub 2020 Jul 7.

S&G Biotech Inc., Yongin, Korea.

Endoscopic ultrasonography (EUS)-guided transmural drainage has been accepted as a modality of choice in peripancreatic fluid collection and acute cholecystitis. Each type of stent, including double-pigtail plastic stents, tubular self-expandable metal stents (SEMS), and lumen-apposing metal stents, for these procedure has its own advantages and disadvantages. To overcome their disadvantages, this animal study evaluated the feasibility of a newly designed twisted fully covered SEMS with spiral coiled ends. Read More

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http://dx.doi.org/10.1038/s41598-020-67374-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341883PMC

Co-Occurrence of Tetrodotoxin and Saxitoxins and Their Intra-Body Distribution in the Pufferfish .

Toxins (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Graduate School of Fisheries and Environmental Sciences, Nagasaki University. 1-14, Bunkyo-machi, Nagasaki, Nagasaki 852-8521, Japan.

Pufferfish of the family Tetraodontidae possess tetrodotoxin (TTX) and/or saxitoxins (STXs), but the toxin ratio differs, depending on the genus or species. In the present study, to clarify the distribution profile of TTX and STXs in Tetraodontidae, we investigated the composition and intra-body distribution of the toxins in . specimens (four male and six female) were collected from Amami-Oshima Island, Kagoshima Prefecture, Japan, and the toxins were extracted from the muscle, liver, intestine, gallbladder, gonads, and skin. Read More

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http://dx.doi.org/10.3390/toxins12070436DOI Listing

Effects of lncRNA MEG3 on proliferation and apoptosis of gallbladder cancer cells through regulating NF-κB signaling pathway.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6632-6638

Department of Ultrasonography, Shanxian Central Hospital, Heze, Shandong, China.

Objective: To explore the effects of long non-coding ribonucleic acid (lncRNA) maternally expressed gene 3 (MEG3) on proliferation and apoptosis of gallbladder cancer (GBC) cells and its molecular mechanism.

Materials And Methods: The relative expression level of lncRNA MEG3 in GBC cell lines was detected via quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR). The lncRNA MEG3 expression plasmids were constructed, the cell proliferation ability was detected via Cell Counting Kit-8 (CCK-8) assay and colony formation assay, and the apoptosis was detected via flow cytometry. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21649DOI Listing

Biliary hyperkinesia: an indication for cholecystectomy?

Surg Endosc 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, St Vincent Indianapolis, Indianapolis, IN, USA.

Background: The main indications for laparoscopic cholecystectomy are stone-related diseases in adults. With a normal abdominal ultrasound (US), a hepatobiliary iminodiacetic acid (HIDA) scan with ejection fraction (EF) is recommended to evaluate gallbladder function. Biliary dyskinesia or low gallbladder EF (EF < 35%) is a recognized indication for cholecystectomy. Read More

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http://dx.doi.org/10.1007/s00464-020-07757-4DOI Listing

EUS guided gallbladder drainage.

Transl Gastroenterol Hepatol 2020 5;5:41. Epub 2020 Jul 5.

Division of Gastroenterology, Hepatology and Nutrition, New York University-Winthrop Hospital, Mineola, NY, USA.

Cholecystectomy is the gold standard treatment for acute cholecystitis, but it may not be appropriate for patients with significant comorbidities. Percutaneous gallbladder drainage (PT-GBD) and endoscopic transpapillary gallbladder drainage (ET-GBD) are alternatives with good technical and clinical success rates, but are limited by technical challenges and the need for definitive therapy. EUS-guided gallbladder drainage (EUS-GBD) is quickly becoming the preferred modality of treatment at expert centers in this cohort of patients due to increased efficacy and minimal adverse events. Read More

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http://dx.doi.org/10.21037/tgh.2019.12.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063510PMC

COVID-19 associated Kawasaki-like multisystem inflammatory disease in an adult.

Am J Emerg Med 2020 Jun 25. Epub 2020 Jun 25.

Division of Rheumatology, Maimonides Medical Center, Brooklyn, NY, United States of America. Electronic address:

Recent reports have described a secondary Multisystem Inflammatory Syndrome in Children (MIS-C) after a prior COVID-19 infection that often has features of Kawasaki disease (KD). Here, we report the case of a 36-year-old woman who presented to the emergency department hypotensive and tachycardic after 1 week of fevers, abdominal pain, vomiting and diarrhea, and was found to have the classic phenotype of complete Kawasaki's Disease including nonexudative conjunctivitis, cracked lips, edema of the hands and feet, palmar erythema, a diffuse maculopapular rash, and cervical lymphadenopathy. Initial laboratory studies were significant for hyponatremia, elevated liver function tests including direct hyperbilirubinemia, and leukocytosis with neutrophilia. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.06.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315983PMC

An unusual complication of pyloric ring obstruction caused by flange of lumen apposing metal stent in endoscopic ultrasound-guided gallbladder drainage: A case report.

Medicine (Baltimore) 2020 Jul;99(27):e21017

Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.

Introduction: Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is an alternative treatment option for patients with acute cholecystitis, especially for those who are unsuitable for cholecystectomy. Recently used luminal apposing metal stents (LAMS) in EUS-GBD has several advantages over standard metal stents. However, there is no current guideline on where to locate the LAMS when transgastric approach is required. Read More

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http://dx.doi.org/10.1097/MD.0000000000021017DOI Listing

Current status and future perspectives of minimally invasive surgery in gallbladder carcinoma.

ANZ J Surg 2020 Jul 5. Epub 2020 Jul 5.

Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, China.

Background: Gallbladder carcinoma (GBC) is the most common biliary tract malignancy, which is characterized by easy local invasion, lymph nodes metastasis, local vascular invasion. Hence, minimally invasive surgery (MIS) can be performed in a limited number of patients. In our study, we reviewed the current studies on laparoscopic surgery (LS) and robotic surgery (RS) for GBC and analysed the limitations and difficulties of MIS for GBC. Read More

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http://dx.doi.org/10.1111/ans.16125DOI Listing

Identification of risk factors for open conversion from laparoscopic cholecystectomy for acute cholecystitis based on computed tomography findings.

Surg Today 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan.

Purpose: Laparoscopic cholecystectomy (LC) is performed widely for acute cholecystitis (AC). This study was conducted to identify the predictors for conversion cholecystectomy (CC) for AC.

Methods: The subjects of this study were 395 patients who underwent emergency surgery for AC between 2011 and 2019. Read More

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http://dx.doi.org/10.1007/s00595-020-02069-5DOI Listing

Increased expression of RBMS3 predicts a favorable prognosis in human gallbladder carcinoma.

Oncol Rep 2020 Jul 23;44(1):55-68. Epub 2020 Apr 23.

Department of General Surgery, The Armed Police Corps Hospital of Anhui, Hefei, Anhui 230041, P.R. China.

Multiple regions in the short arm of chromosome 3 are frequently deleted in a variety of solid tumors including gallbladder carcinoma (GBC). RNA binding motif, single‑stranded interacting protein 3 (RBMS3), a tumor suppressor gene (TSG), is located in this region. However, the role of RBMS3 in GBC remains unclear. Read More

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http://dx.doi.org/10.3892/or.2020.7594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251710PMC

Feasibility of endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis patients receiving antithrombotic therapy.

Ann Gastroenterol 2020 Jul-Aug;33(4):391-397. Epub 2020 May 15.

Department of Endoscopy, New Tokyo Hospital, Chiba (Yuji Amano), Japan.

Background: Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) as a treatment for patients with acute cholecystitis has been shown to obtain high technical and clinical success rates and a low recurrence rate. However, the safety of EUS-GBD for patients receiving antithrombotic therapy (ATT) has not been proven. The aim was to evaluate the safety and efficacy of EUS-GBD in patients receiving ATT. Read More

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http://dx.doi.org/10.20524/aog.2020.0496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315717PMC

Gallbladder wall thickening on bedside ultrasound in a child with Epstein-Barr virus infection.

BMJ Case Rep 2020 Jul 5;13(7). Epub 2020 Jul 5.

Pediatrics, Kaplan Medical Center, Rehovot, Israel.

Gallbladder wall thickening (GBWT) is rarely reported in children with acute Epstein-Barr virus (EBV) infection. We present a child with EBV infection who was found on point-of-care ultrasound to have GBWT without signs of cholecystitis that subsequently resolved without intervention. We expect the proliferation of mobile and handheld sonography to increase the number of bedside examinations in febrile children. Read More

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http://dx.doi.org/10.1136/bcr-2020-234486DOI Listing

Eosinophilic cholecystitis in children: Case series.

J Pediatr Surg 2020 Jun 3. Epub 2020 Jun 3.

Fundación Hospital Pediátrico La Misericordia, Bogota, Columbia.

Introduction: Eosinophilic cholecystitis (EC) is rarely seen in the pediatric population. Most of the available literature comes from adult patients, while only anecdotal cases have been reported in children.

Objective: To describe the clinical course, management, and outcomes of all EC cases treated at a children's hospital. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.039DOI Listing

Ectopic gallbladder: A case report and review of the literature.

Authors:
Wang Gu Zhong Tong

Asian J Surg 2020 Jul 1. Epub 2020 Jul 1.

Anhui Medical University Third Affiliated Hospital, 390 Huaihe Road, Luyang District, Hefei City, Anhui Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2020.05.017DOI Listing

Gallbladder cancer with EGFR mutation and its response to GemOx with erlotinib: a case report and review of literature.

World J Surg Oncol 2020 Jul 4;18(1):153. Epub 2020 Jul 4.

Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.

Background: Gallbladder cancer (GBC) is the most common and aggressive extra hepatic biliary tree cancer (BTC) with dismal outcome. Complete surgical resection is the treatment of choice. Chemotherapy is used for palliation in advanced GBC where surgery is not possible, and the most commonly used agent is gemcitabine in combination with cisplatin or oxaliplatin or with capecitabine regimens. Read More

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http://dx.doi.org/10.1186/s12957-020-01934-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335444PMC

Specific radiological findings, if present, can offer high accuracy for the differentiation of Xanthogranulomatous cholecystitis and gallbladder cancer.

Authors:
Hideki Suzuki

Ann Transl Med 2020 Jun;8(11):662

Department of Hepatobiliary and Pancreatic Surgery, Isesaki Municipal Hospital, Gunma, Japan.

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http://dx.doi.org/10.21037/atm.2020.03.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327357PMC

Histopathological findings in a COVID-19 patient affected by ischemic gangrenous cholecystitis.

World J Emerg Surg 2020 07 2;15(1):43. Epub 2020 Jul 2.

Digestive Surgery Unit, Department of Science of Health, "Magna Graecia" University, Catanzaro, Italy.

Background: Since its first documentation, a novel coronavirus (SARS-CoV-2) infection has emerged worldwide, with the consequent declaration of a pandemic disease (COVID-19). Severe forms of acute respiratory failure can develop. In addition, SARS-CoV-2 may affect organs other than the lung, such as the liver, with frequent onset of late cholestasis. Read More

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http://dx.doi.org/10.1186/s13017-020-00320-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330255PMC

EUS-guided gallbladder drainage versus laparoscopic cholecystectomy for acute cholecystitis: a propensity score analysis with 1-year follow-up data.

Gastrointest Endosc 2020 Jun 29. Epub 2020 Jun 29.

Department of Surgery, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.

Background And Aims: EUS-guided gallbladder drainage (EUS-GBD) is a safe alternative to percutaneous cholecystostomy (PT-GBD) for acute cholecystitis. How the procedure compares with laparoscopic cholecystectomy (LC) is uncertain. The aim of the current study is to compare the outcomes of EUS-GBD with LC for acute cholecystitis. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.066DOI Listing

Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation.

Liver Int 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Background: Biliary cancer, comprising cholangio- and gallbladder carcinomas, is associated with high mortality due to asymptomatic disease onset and resulting late diagnosis. Currently, no robust diagnostic biomarker is clinically available. Therefore, we explored the feasibility of extracellular vesicles (EVs) as a liquid biopsy tool for biliary cancer screening and hepatobiliary cancer differentiation. Read More

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http://dx.doi.org/10.1111/liv.14585DOI Listing

Omega Hepatojejunostomy and Hepatic Haemostasis Using the Electrocautery Greased with Lidocaine Gel.

Chirurgia (Bucur) 2020 May-Jun;115(3):380-384

When the entire hepatic pedicle is invaded by a tumour, the treatment of cholestasis represents a challenge both for choosing the best drainage possibility and for performing the liver haemostasis during a surgical procedure. Case Report: A patient with progressive jaundice resulting from a remaining gastric tumour that invaded the gallbladder and the hepatic pedicle was successfully treated with biliary decompression using the omega hepaticojejunal shunt. The minor parenchymal bleeding was achieved with the electrocautery greased with lidocaine gel. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.380DOI Listing

Neutrophils as Main Players of Immune Response Towards Nondegradable Nanoparticles.

Nanomaterials (Basel) 2020 Jun 29;10(7). Epub 2020 Jun 29.

Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nurnberg (FAU), Universitatsklinikum Erlangen, 90154 Erlangen, Germany.

Many nano/microparticles (n/µP), to which our body is exposed, have no physiological way of removal. Our immune system sense these "small particulate objects", and tries to decrease their harmfulness. Since oxidation, phagocytosis and other methods of degradation do not work with small, chemically resistant, and hydrophobic nanoparticles (nP). Read More

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http://dx.doi.org/10.3390/nano10071273DOI Listing

[Nomenclature correction of "incidental gallbladder cancer" and its prevention strategies].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):490-493

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Incidental gallbladder cancer(IGBC) originated in the West more than half a century ago.IGBC was translated and introduced into China afterwards with widespread clinical application.With the popularization of laparoscopic cholecystectomy, the trend of "abuse" of IGBC has become increasingly apparent worldwide. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200302-00174DOI Listing

[Gallbladder metastasis of lung adenocarcinoma: report of a case].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):751-753

Department of Pathology, the Ninth People's Hospital of Suzhou, Jiangsu Province, Suzhou 215200, China.

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http://dx.doi.org/10.3760.j.cma.cn112151-20191009-00550DOI Listing

Presentation of gallbladder torsion at an abnormal position: A case report.

World J Clin Cases 2020 Jun;8(12):2667-2673

Department of Hepatobiliary Surgery, Yuncheng Central Hospital, the Eighth Clinical College of Shanxi Medical University, Yuncheng 044031, Shanxi Province, China.

Background: Gallbladder torsion is a rare acute abdominal condition that requires emergency surgery. It occurs more commonly in elderly people and in women in the adult population. Diagnosis is a challenge as non-specific symptoms and signs have been reported on ultrasonography, computed tomography and magnetic resonance imaging. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322416PMC

Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study.

Clin Epidemiol 2020 19;12:659-666. Epub 2020 Jun 19.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Background: The effect of blood transfusions on the risk of developing primary cancer remains unclear, especially when administered in the peripartum period.

Materials And Methods: We conducted a retrospective cohort study of 270,529 pregnant women who delivered between January 1, 2007 and December 31, 2009, with data obtained from three national databases in South Korea. From this cohort, we identified 4569 patients who received peripartum blood transfusions. Read More

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http://dx.doi.org/10.2147/CLEP.S244443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310970PMC

Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma.

Cancer Manag Res 2020 12;12:4475-4482. Epub 2020 Jun 12.

Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.

Purpose: This study aimed to evaluate the efficiency of several parameters, including the neutrophil-to-lymphocyte ratio (NLR) obtained from preoperative routine blood examination, either alone or as an adjunct to the carbohydrate antigen 19-9 (CA19-9), for the diagnosis of gallbladder carcinoma (GBC).

Patients And Methods: Data from 123 patients with gallbladder cholesterol polyps (GCP), 80 with gallbladder adenoma (GA), and 103 with GBC were reviewed retrospectively. Receiver operating characteristic analysis was used to assess the sensitivity, specificity, and clinical value of the NLR, CA19-9, and their combination. Read More

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http://dx.doi.org/10.2147/CMAR.S255480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297325PMC

Cholecystectomy - a potential selection bias in studies assessing the metabolic effects of bariatric surgeries.

Sci Rep 2020 Jun 30;10(1):10683. Epub 2020 Jun 30.

Department of Gastroenterology, Laboratory of Nutrition and Metabolic Surgery of the Digestive Tract (LIM 35), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Bile acids (BAs) are key mediators of the glycemic control after bariatric surgeries. Cholecystectomy modifies the kinetics of BAs, and whether this procedure influences the BAs pool and its metabolic response to bariatric surgeries is not known. We used targeted and untargeted metabolomics to assess whether cholecystectomy influenced plasma and fecal BAs fluctuations and the systemic metabolomic profile after Roux-en-Y gastric bypass (RYGB). Read More

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http://dx.doi.org/10.1038/s41598-020-66688-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327072PMC

Preoperative C-Reactive Protein/Albumin Ratio as a Predictive Factor for Gallbladder Carcinoma.

In Vivo 2020 Jul-Aug;34(4):1901-1908

Department of Surgery, National Hospital Organization, Iwakuni Clinical Center, Yamaguchi, Japan.

Background/aim: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection.

Patients And Methods: Fifty-three patients who underwent surgical resection for GBC between January 2008 and September 2019 were enrolled. Read More

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http://dx.doi.org/10.21873/invivo.11986DOI Listing

Less is more in the difficult gallbladder: recent evolution of subtotal cholecystectomy in a single HPB unit.

Surg Endosc 2020 Jun 29. Epub 2020 Jun 29.

Section of Hepato-Pancreato-Biliary Surgery, Siteman Cancer Center, Barnes-Jewish Hospital, and Washington University School of Medicine in St. Louis, St Louis, MO, USA.

Introduction: Subtotal cholecystectomy (SC) is a technique to manage the difficult gallbladder and avoid hazardous dissection and biliary injury. Until recently it was used infrequently. However, because of reduced exposure to open total cholecystectomy in resident training, we recently adopted subtotal cholecystectomy as the bail-out procedure of choice for resident teaching. Read More

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http://dx.doi.org/10.1007/s00464-020-07759-2DOI Listing

Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation.

PLoS Negl Trop Dis 2020 Jun 29;14(6):e0008421. Epub 2020 Jun 29.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: The liver fluke, Opisthorchis felineus, is widely distributed throughout Europe and large parts of the Russian Federation. In Western Siberia, information about opisthorchiasis is lacking although infection may lead to severe liver and bile duct diseases. We aimed to assess the current prevalence of O. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008421DOI Listing

What Should be Done for Perforation of the Gallbladder During Laparoscopic Cholecystectomy: Prophylaxis or Treatment?

J Laparoendosc Adv Surg Tech A 2020 Jun 26. Epub 2020 Jun 26.

Department of General Surgery, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey.

Iatrogenic perforation of the gallbladder during laparoscopic cholecystectomy (LC) is one of the most common intraoperative complications, and there is no clear consensus among surgeons on this issue and there are studies reporting the antibiotic treatment. The aim of this study is to determine the effect of type and duration of antibiotic use on infective complications between iatrogenic perforations of the gallbladder during LC patients. Patients who developed iatrogenic perforation of gallbladder during LC were subdivided into three groups according to antibiotic treatment; single dose intravenous (i. Read More

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http://dx.doi.org/10.1089/lap.2020.0322DOI Listing

The reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.

Am J Physiol Gastrointest Liver Physiol 2020 Jun 29. Epub 2020 Jun 29.

Department of General Surgery, Shanghai General Hospita, Shanghai Jiao Tong University School of Medicine, Shanghai, China, China.

The purpose of this study was to demonstrate the aberrant metabolism of bile acids in patients with cholesterol gallstone and explore for its underlying mechanisms.The composition of bile acids collected from the patients with cholelithiasis and the control individuals was analyzed by LC-MS. The expression of genes regulating the metabolism of bile acids were quantitatively determined by real-time PCR or Western blotting. Read More

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http://dx.doi.org/10.1152/ajpgi.00385.2019DOI Listing

Immunoglobulin G4-related cholecystitis mimicking a locally advanced gallbladder cancer-a case report and review of literature.

Clin J Gastroenterol 2020 Jun 28. Epub 2020 Jun 28.

Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Parel, 400012, Mumbai, India.

Immunoglobulin G4 (IgG4)-related disease is a multi-organ immune-mediated condition that can mimic many inflammatory, malignant, and infectious disorders. Isolated IgG4-related cholecystitis without systemic manifestation is extremely rare. We report a rare case of IgG4-related disease with its clinical, radiological and histopathological findings involving only the gallbladder which presented initially as unresectable locally advanced gallbladder cancer on imaging but was diagnosed as IgG4-related cholecystitis preoperatively depending upon serum IgG4 levels and immunohistochemistry. Read More

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http://dx.doi.org/10.1007/s12328-020-01168-7DOI Listing

Aflatoxicosis in cattle: clinical findings and biochemical alterations.

Environ Sci Pollut Res Int 2020 Jun 27. Epub 2020 Jun 27.

Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt.

Aflatoxicosis is a serious health condition resulted from aflatoxin (AF)-producing fungi. Major health threats resulted from AFs and reflect on the livestock industry with great economic losses. There are limited scientific evidences concerning the AFs in ruminant, therefore it is important to evaluate AFs health hazards in cattle. Read More

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http://dx.doi.org/10.1007/s11356-020-09489-3DOI Listing

Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases.

World J Surg Oncol 2020 Jun 26;18(1):142. Epub 2020 Jun 26.

Department of Traditional Chinese Medicine, Shanxi Provincial People's Hospital, Taiyuan, 030012, China.

Objective: The aim of the study is to evaluate the impact of application of surgical strategies at different cancer stages on the survival of gallbladder cancer (GBC) patients.

Methods: The patients with GBC were divided into 3 groups according to their received surgical strategies: simple resection (full-thickness cholecystectomy for removal of primary tumor site), radical resection (gallbladder bed removal combined with partial hepatectomy), and palliative surgery (treatment at advanced stages). The overall survival (OS) of GBC patients who were received different surgical strategies was compared. Read More

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http://dx.doi.org/10.1186/s12957-020-01915-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320575PMC