42,052 results match your criteria Gallbladder


IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction.

Histopathology 2019 Mar 18. Epub 2019 Mar 18.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

Aims: To investigate whether genetic or inflammatory pro-oncogenic factors are relevant to the increased risk of gallbladder cancers in patients with pancreaticobiliary maljunction (PBM).

Methods: Mutations in KRAS exon 2 were examined by a highly sensitive, droplet digital PCR platform using surgically resected specimens of PBM-associated (n=31) and non-associated gallbladder cancers (n=49). The tissue expression of IL-6 and IL-33, which are suspected to promote biliary carcinogenesis, was analyzed by quantitative real-time PCR and in situ hybridization. Read More

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http://dx.doi.org/10.1111/his.13863DOI Listing

Can surgical treatment be justified for neuroendocrine carcinoma of the gallbladder?

Medicine (Baltimore) 2019 Mar;98(11):e14886

Department of Surgery, Seoul National University College of Medicine, Surgery, Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.

Clinical features and treatment of GB neuroendocrine carcinoma (GB-NEC) are not well understood. This study aimed to analyze clinical outcomes of GB-NEC and verify the oncologic benefit of surgical treatment.From October 1994 to December 2014, the medical records of 31 patients with GB-NEC at a single center were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014886DOI Listing
March 2019
1 Read

Massive hemoperitoneum and upper gastrointestinal hemorrhage following liver rupture secondary to gallbladder perforation: A case report and literature review.

Medicine (Baltimore) 2019 Mar;98(11):e14729

Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chendu, Sichuan.

Rationale: Available literature states that the common reasons for non-traumatic spontaneous liver rupture are hepatocellular carcinoma, macronodular cirrhosis, hemangioma, and other tumors; gallbladder perforation is not cited as a cause.

Patient Concerns: The patient presented with sudden-onset right upper quadrant pain with tarry stool for 3 days after eating with dysphoria and increasing thirst; gradually, hemorrhagic shock developed. He had no history of trauma, no background of chronic hepatitis, and no cirrhosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014729DOI Listing

Carcinosarcoma of the Gallbladder with Chondrosarcomatous Differentiation and Intracytoplasmic Eosinophilic Hyaline Globules (Thanatosomes): A Report of a Case and Review of the Literature.

Case Rep Pathol 2019 6;2019:9697235. Epub 2019 Feb 6.

Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Amer Bin Thabet Street, Dammam 31444, Saudi Arabia.

A 52-year-old woman presented with abdominal pain and vomiting. Computed tomography (CT) scan of the abdomen revealed a huge exophytic gallbladder mass displacing or invading the surrounding structures. The patient underwent radical cholecystectomy, transverse colectomy, distal gastrectomy, and liver bed resection. Read More

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http://dx.doi.org/10.1155/2019/9697235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381573PMC
February 2019

Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer.

Oncol Lett 2019 Apr 14;17(4):3890-3898. Epub 2019 Feb 14.

Department of Gastroenterology, University Hospital Heidelberg, D-69120 Heidelberg, Germany.

Recently, a tumor-autonomous cytochrome P450 (CYP)-3A5-mediated resistance to cancer therapy has been demonstrated in pancreatic ductal adenocarcinoma. Expression of CYP3A5, which is involved in the degradation of irinotecan, has also been reported in colorectal cancer (CRC). The aim of the present study was to analyze CYP3A5 expression in the normal colon, colon adenoma, CRC and normal tissues, as well as to examine whether CYP3A5 expression in CRC has an impact on tumor response to irinotecan treatment. Read More

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http://dx.doi.org/10.3892/ol.2019.10043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403523PMC

Prospective observational study on cholelithiasis in patients with carcinoma gall bladder in a tertiary referral hospital of Eastern India.

J Cancer Res Ther 2019 Jan-Mar;15(1):153-156

Department of Surgery, IPGMER/SSKM Hospital; Department of Surgical Oncology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India.

Context: Gallbladder carcinoma (GBCA) is the fifth most common types of gastrointestinal malignancy and is the most common malignancy of the biliary tract. Cholelithiasis, gallbladder polyps, porcelain gall, and choledochal cysts are common known associations with GBCA. Because of the better understanding of the etiopathogenesis, the traditional nihilistic attitude toward the prognosis has, over the years, given way to greater interest and hope for treating the disease. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_939_17DOI Listing

Correlation of dyslipidemias and gallbladder polyps-A large retrospective study among Chinese population.

Asian J Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: Aim to explore the association of dyslipidemias with GBP prevalence, number and size in a large Chinese population in Beijing. Dyslipidemias include hypercholesterolemia, hypertriglyceridemia, increased low density lipoprotein (LDL) and decreased high density lipoproteins (HDL).

Methods: Prevalence of GBP and its association with dyslipidemias were retrospectively investigated among subjects who underwent check-up at Health Screening Center of Xuanwu Hospital between January 2014 and December 2017. Read More

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http://dx.doi.org/10.1016/j.asjsur.2019.01.013DOI Listing

Laparoscopic left lateral sectionectomy for a patient with right-sided ligamentum teres.

Surg Case Rep 2019 Mar 15;5(1):43. Epub 2019 Mar 15.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

Background: A right-sided ligamentum teres (RSLT) is a rare congenital anomaly in which the fetal umbilical vein is connected to the right paramedian trunk. RSLT creates difficulty in liver resection with respect to decision-making regarding the resection line, deviation of the vasculobiliary architecture. We report a case in which laparoscopic left lateral sectionectomy (LLLS) was performed to treat colorectal liver metastasis (CRLM) in a patient with RSLT. Read More

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http://dx.doi.org/10.1186/s40792-019-0601-1DOI Listing

An unusual site of gallstones five years after laparoscopic cholecystectomy.

Int J Surg Case Rep 2019 Mar 5;56:107-109. Epub 2019 Mar 5.

Department of General Surgery, Moruya District Hospital, 2 River Street, Moruya, NSW, 2537, Australia.

Introduction: Gallstone spillage during laparoscopic cholecystectomy is a common occurrence. Complications due to spilled gallstones occur in up to 5% of laparoscopic cholecystectomy cases, with complications having been reported up to 20 years after laparoscopic cholecystectomy.

Case Report: We report the case of a 70 year old male who presented for elective right inguinal hernia repair. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.038DOI Listing

[Immune-mediated cholangiopathies : Diagnostic and therapeutic challenges].

Authors:
T Herta U Beuers

Radiologe 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology and Hepatology and Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center, AMC, C2-327, Meibergdreef 9, 1105 AZ, Amsterdam, Niederlande.

Background: Immune-mediated cholangiopathies comprise primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and IgG4-associated cholangitis (IAC). A common feature is the progressive destruction of bile ducts leading to cholestasis with fibrosis and cirrhosis of the liver over time. The diseases are mostly identified during routine laboratory testing. Read More

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http://dx.doi.org/10.1007/s00117-019-0513-xDOI Listing

Gallbladder volvulus: A rare cause of acute gallbladder distension.

J Gastroenterol Hepatol 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, Centre Hospitalier Avranches-Granville, Avranches, France.

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http://dx.doi.org/10.1111/jgh.14619DOI Listing

Endoscopic Ultrasonography-Guided Gallbladder Drainage as a Treatment Option for Acute Cholecystitis after Metal Stent Placement in Malignant Biliary Strictures.

Clin Endosc 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan.

Background/aims: : It is often difficult to manage acute cholecystitis after metal stent (MS) placement in unresectable malignant biliary strictures. The aim of this study was to evaluate the feasibility of endoscopic ultrasonography-guided gallbladder drainage (EUS-GBD) for acute cholecystitis.

Methods: : The clinical outcomes of 10 patients who underwent EUS-GBD for acute cholecystitis after MS placement between January 2011 and August 2018 were retrospectively evaluated. Read More

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http://dx.doi.org/10.5946/ce.2018.183DOI Listing

Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease.

Biosci Trends 2019 ;13(1):1-9

Department of Oncology, XinHua Hospital, Shanghai Jiao Tong University.

Since the American Joint Committee on Cancer (AJCC) subdivided the T2 stage of gallbladder carcinoma (GBC) into T2a and T2b, the diagnosis and treatment of those stages have been a subject of heated discussion and controversy. T2 is a stage of GBC that might be treatable. Based on the extent of lymph node metastasis and distant metastasis, T2 GBC can be classified into various pathological stages such as IIA, IIB, IIIB, and IVB, leading to controversy in clinical settings. Read More

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http://dx.doi.org/10.5582/bst.2019.01039DOI Listing
January 2019
1 Read

The optimal number of lymph nodes to evaluate among patients undergoing surgery for gallbladder cancer: Correlating the number of nodes removed with survival in 6531 patients.

J Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, Ohio.

Background: The aim of the current study was to identify the minimum number and the optimal range of lymph nodes (LNs) to be examined among patients with gallbladder cancer (GBC).

Methods: Between January 1, 2004, and December 31, 2015, patients with a diagnosis of GBC were identified in the National Cancer Database. A machine-based learning approach was used to identify the minimum number and range of LNs to evaluate relative to long-term outcomes. Read More

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http://dx.doi.org/10.1002/jso.25450DOI Listing

Bile acid homeostasis in a Cyp7a1 & Cyp27a1 double knockout mouse model.

Hepatology 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmacology and Toxicology, School of Pharmacy, EOHSI, Rutgers University, Piscataway, NJ, 08854, United States.

Bile acids (BAs) are diverse molecules that are synthesized from cholesterol in the liver. The synthesis of BAs has traditionally been shown to occur via two pathways. Cholesterol 7α-hydroxylase (CYP7A1) performs the initial and rate-limiting step in the classical pathway and sterol 27-hydroxylase (CYP27A1) initiates the hydroxylation of cholesterol in the alternative pathway. Read More

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http://dx.doi.org/10.1002/hep.30612DOI Listing

Risk of cancer in infertile women: analysis of us claims data.

Hum Reprod 2019 Mar 13. Epub 2019 Mar 13.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford Hospital and Clinics, Stanford, CA, USA.

Study Question: Is female infertility associated with higher risk of cancer?

Summary Answer: Although absolute risks are low, infertility is associated with higher risk of cancer compared to a group of non-infertile women.

What Is Known Already: Infertile women are at higher risk of hormone-sensitive cancers. Information on risk of non-gynecologic cancers is rare and conflicting, and the effect of pregnancy on these risk associations is known for only a minority of cancer types. Read More

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https://academic.oup.com/humrep/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/humrep/dez018DOI Listing
March 2019
4 Reads

Laparoscopic radical cholecystectomy with common bile duct resection for T2 gallbladder cancer.

Ann Hepatobiliary Pancreat Surg 2019 Feb 28;23(1):69-73. Epub 2019 Feb 28.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

The oncologic safety and feasibility of laparoscopic radical cholecystectomy for a preoperatively suspected gallbladder cancer is continually being challenged even in an era of minimally invasive surgery. A seventy-four-year-old woman was presented in the outpatient department with a history of fever, abdominal pain, and vomiting. CT scan showed an irregular wall thickening of the body to the cystic duct of the gallbladder and portocaval lymph node. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14701/ahbps.2019
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http://dx.doi.org/10.14701/ahbps.2019.23.1.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405374PMC
February 2019
3 Reads

Epidemiology and disease characteristics of symptomatic choledocholithiasis in Sri Lanka.

Ann Hepatobiliary Pancreat Surg 2019 Feb 28;23(1):41-45. Epub 2019 Feb 28.

Department of Surgery, Faculty of Medical Sciences, University of Sri Jayewardenepura, Colombo, Sri Lanka.

Backgrounds/aims: Published data on choledocholithiasis in Sri Lanka is scarce. This study was conducted to determine epidemiological, clinical and endoscopic characteristics of choledocholithiasis in Sri Lanka.

Methods: This was a retrospective study of consecutive patients for a period of three years until April 2016. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14701/ahbps.2019
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http://dx.doi.org/10.14701/ahbps.2019.23.1.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405359PMC
February 2019
2 Reads

Gangrenous cholecystitis in male patients: A study of prevalence and predictive risk factors.

Ann Hepatobiliary Pancreat Surg 2019 Feb 28;23(1):34-40. Epub 2019 Feb 28.

Department of General Surgery, Maggiore Hospital, Parma, Italy and Department of Surgery, "Infermi" Hospital, Rimini, Italy.

Backgrounds/aims: The prevalence and risk factors of gangrenous cholecystitis in male are unknown.

Objective: To verify the prevalence and risk factors of gangrenous cholecystitis in males.

Methods: This cross-sectional study includes 95 patients (59. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14701/ahbps.2019
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http://dx.doi.org/10.14701/ahbps.2019.23.1.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405364PMC
February 2019
2 Reads

Preoperative fasting hyperglycemia is an independent prognostic factor for postoperative survival after gallbladder carcinoma radical surgery.

Cancer Manag Res 2019 12;11:1425-1432. Epub 2019 Feb 12.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China,

Background: Preoperative high blood glucose levels are closely associated with poor performance and high mortality in cancer patients. This study was designed to investigate the relationship between preoperative fasting hyperglycemia and the prognosis of patients with gallbladder cancer (GBC) after undergoing GBC radical surgery.

Patients And Methods: A retrospective analysis of 83 eligible patients who underwent GBC radical surgery between 2007 and 2016 was performed. Read More

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http://dx.doi.org/10.2147/CMAR.S192273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388958PMC
February 2019

The safety of newly developed automatic temperature-controlled endobiliary radiofrequency ablation system for malignant biliary strictures: a prospective multicenter study.

J Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Digestive Disease Center and Research Institute, Department of Internal Medicine, SoonChunHyang University School of Medicine, Korea.

Background And Aims: Catheter-based endobiliary radiofrequency ablation (RFA) is an endoscopic local treatment for patients with malignant biliary stricture (MBS). However, excessive heating of the bile duct by the current RFA system can induce serious complications. Recently, a new RFA system with automatic temperature control was developed. Read More

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http://doi.wiley.com/10.1111/jgh.14657
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http://dx.doi.org/10.1111/jgh.14657DOI Listing
March 2019
2 Reads

Rendez-Vous laparoendoscopic after ERCP failure in patient with Billroth II gastrectomy.

Rev Gastroenterol Peru 2018 Oct-Dec;38(4):384-387

Departmentof Surgery, University of Sao Paulo. Sao Paulo, Brazil.

Endoscopic retrograde cholangiopancreatography (ERCP) is the treatment of choice in patients with choledocholithiasis. However,despite its high success rate, in some cases it is not successful, requiring alternative therapy. Billroth II partial gastrectomy is a condition associated with an important failure rate of ERCP. Read More

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March 2019
1 Read

Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans.

Parasitology 2019 Mar 12:1-8. Epub 2019 Mar 12.

Department of Pathology,Yale University School of Medicine,New Haven, CT 06520-8023,USA.

Cystoisospora (Isospora) belli is a coccidian parasite of humans. It can cause serious digestive disorders involving infection of intestines, biliary tract and gallbladder, especially in those with depressed immunity. It has a direct fecal-oral transmission cycle. Read More

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http://dx.doi.org/10.1017/S003118201900012XDOI Listing
March 2019
1 Read

Case report: Cholecystoduodenostomy for cholestatic liver disease in a premature infant with cystic fibrosis and short gut syndrome.

BMC Pediatr 2019 Mar 11;19(1):78. Epub 2019 Mar 11.

Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales, Sydney, NSW, Australia.

Background: Cholecystoduodenostomy is a surgical procedure that bypasses the extrahepatic biliary tree and connects the gallbladder directly to the duodenum. This case describes the successful use of this procedure in a novel situation.

Case Presentation: A premature (34 weeks gestation) female infant with cystic fibrosis required a laparotomy on day 1 of life due to an intrauterine small bowel perforation. Read More

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http://dx.doi.org/10.1186/s12887-019-1443-5DOI Listing

Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline.

J Clin Oncol 2019 Mar 11:JCO1802178. Epub 2019 Mar 11.

13 Winship Cancer Institute, Emory University, Atlanta, GA.

Purpose: To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with resected biliary tract cancer.

Methods: ASCO convened an Expert Panel to conduct a systematic review of the literature on adjuvant therapy for resected biliary tract cancer and provide recommended care options for this patient population.

Results: Three phase III randomized controlled trials, one phase II trial, and 16 retrospective studies met the inclusion criteria. Read More

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http://dx.doi.org/10.1200/JCO.18.02178DOI Listing
March 2019
1 Read

[Metachronous intraductal papillary mucinous carcinoma five years after cholecystectomy for gallbladder cancer in a patient with pancreaticobiliary maljunction].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(3):241-248

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

A 71-year-old female with non-dilated pancreaticobiliary maljunction (PBM) and gallbladder polypoid lesions underwent laparoscopic cholecystectomy. Histological examination of the polypoid lesions revealed gallbladder cancer. Five years after cholecystectomy, gradual dilatation of the main pancreatic duct (MPD) led to the identification of a papillary tumor growing in the MPD of the pancreatic head. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.241DOI Listing
January 2019
1 Read

Minimally Invasive Surgery for Gallbladder Cancer.

Surg Oncol Clin N Am 2019 04 2;28(2):243-253. Epub 2019 Feb 2.

Department of Digestive Surgery, Faculty of Medicine, Catholic University of Chile, Avenida Libertador Bernardo O'Higgins 390, Santiago 8331150, Chile; Department of Digestive Surgery, Faculty Medicine, Catholic University of Chile, Sotero del Rio Hospital, Concha y Toro Avenue 3459, Puente Alto, Santiago 8207257, Chile. Electronic address:

There is consensus that oncologic extended resection should be performed for resectable incidental and nonincidental gallbladder cancer. The safety and feasibility of a minimally invasive approach to oncologic extended resection of gallbladder cancer has been demonstrated and is performed in centers of expertise worldwide. In this article, a systematic approach to the indications and techniques for a minimally invasive approach to extended resection for gallbladder cancer is detailed. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.001DOI Listing

Case report of a duplicated cystic duct: A unique challenge for the laparoscopic surgeon.

Int J Surg Case Rep 2019 Feb 28;56:78-81. Epub 2019 Feb 28.

Department of Surgery/Division of Trauma and Acute Care Surgery, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.

Introduction: Anatomical variants of the extrahepatic biliary tree are numerous, adding significantly to the risk of bile duct injury during cholecystectomy, especially when laparoscopic approach is employed. Duplicated cystic ducts draining a single gallbladder are extremely rare.

Presentation Of Case: A 34-year-old female presented with signs and symptoms of acute cholecystitis which was confirmed on imaging. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.030DOI Listing
February 2019
1 Read

Top research priorities in liver and gallbladder disorders in the UK.

BMJ Open 2019 Mar 7;9(3):e025045. Epub 2019 Mar 7.

Hepatology, Royal Gwent Hospital, Newport, UK.

Objectives: There is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders priority setting partnership was established to identify the top research priorities in the prevention, diagnostic and treatment of gallbladder disorders and liver disorders not covered by the James-Lind Alliance (JLA) alcohol-related liver disease priority setting partnership.

Design: The methods broadly followed the principles of the JLA guidebook. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02504
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http://dx.doi.org/10.1136/bmjopen-2018-025045DOI Listing
March 2019
1 Read

Characterization of the self-assembly and size dependent structural properties of dietary mixed micelles by molecular dynamics simulations.

Biophys Chem 2019 Feb 5. Epub 2019 Feb 5.

İzmir Institute of Technology, Food Engineering Department, Gulbahce Campus,Urla, Izmir 35430, Turkey. Electronic address:

The bile salts and phospholipids are secreted by the gallbladder to form dietary mixed micelles in which the solvation of poorly absorbed lipophilic drugs and nutraceuticals take place. A comprehensive understanding of the micellization and structure of the mixed micelles are crucial to design effective delivery systems for such substances. In this study, the evolution of the dietary mixed micelle formation under physiologically relevant concentrations and the dependence of structural properties on micelle size were investigated through coarse-grained molecular dynamics simulations. Read More

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http://dx.doi.org/10.1016/j.bpc.2019.02.001DOI Listing
February 2019

Uncommon site of metastasis from renal cell carcinoma: Case report.

Int J Surg Case Rep 2019 Feb 13;56:45-48. Epub 2019 Feb 13.

Department of Oncology, Real e Benemérita Associação Portuguesa de Beneficência, Brazil.

Background: Renal cell carcinomas (CCR) account for 90% of renal tumors. Presence of latent distant metastasis is characteristic of RCC and may manifest more than a decade after nephrectomy. Gallbladder (GB) is a rare site of metastasis, with few reports in the literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193007
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http://dx.doi.org/10.1016/j.ijscr.2019.02.013DOI Listing
February 2019
6 Reads

[Gallbladder epidermoid carcinoma].

Rev Med Chil 2018 Dec;146(12):1438-1443

Departamento de Cirugía Oncológica Gastrointestinal, Instituto Nacional de Cancerología, México.

Background: Gallbladder epidermoid carcinoma is rare and more common in women over 55 years of age.

Aim: To report the features of 15 patients with gallbladder epidermoid carcinoma.

Material And Methods: Review of medical records of patients with gallbladder cancer in an oncology service. Read More

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http://dx.doi.org/10.4067/s0034-98872018001201438DOI Listing
December 2018
3 Reads

Histopathological Examination of Gallbladder Specimens in Kumaon Region of Uttarakhand.

J Gastrointest Cancer 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Government Medical College, Haldwani, Nainital, Uttarakhand, 263139, India.

Gall stones are one of the major causes of morbidity and mortality all over the world and common health problems throughout in developing countries. Cholecystectomy is one of the most common surgical practices and postoperative analysis of cholecystectomy specimen has a great value since histopathological reports may document some entities with significant clinical significances. Gallbladder carcinomas in cholecystectomy specimens are received in our histopathology laboratory to analyse their clinicopathological features. Read More

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http://dx.doi.org/10.1007/s12029-018-00188-4DOI Listing
March 2019
1 Read

Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound-Guided Gallbladder Drainage.

Gastrointest Endosc Clin N Am 2019 Apr;29(2):293-310

Icahn School of Medicine at Mount Sinai, Dr. Henry D. Janowitz Division of Gastroenterology, One Gustave L. Levy Place, Box 1069, New York, NY 10029, USA. Electronic address:

"Gallbladder disease is one of the most common gastrointestinal diseases encountered in clinical practice. Surgical removal and percutaneous drainage are both widely available and effective in the management of acute cholecystitis. Several endoscopic approaches exist as an alternative to these interventions. Read More

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http://dx.doi.org/10.1016/j.giec.2018.12.002DOI Listing
April 2019
1 Read

Gallbladder Cancer: Diagnosis, Surgical Management, and Adjuvant Therapies.

Surg Clin North Am 2019 Apr;99(2):337-355

Division of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Gallbladder cancer (GBC) is an often lethal disease, but surgical resection is potentially curative. Symptoms may be misdiagnosed as biliary colic; over half of new diagnoses are made after laparoscopic cholecystectomy for presumed benign disease. Gallbladder polyps >1 cm should prompt additional imaging and cholecystectomy. Read More

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http://dx.doi.org/10.1016/j.suc.2018.12.008DOI Listing
April 2019
1 Read

Bile Metabolism and Lithogenesis: An Update.

Surg Clin North Am 2019 Apr;99(2):215-229

Department of Surgery, University of California Irvine; Hepatobiliary and Pancreas Surgery, Department of Surgery, University of California Irvine, Orange, CA, USA. Electronic address:

Bile is composed of multiple macromolecules, including bile acids, free cholesterol, phospholipids, bilirubin, and inorganic ions that aid in digestion, nutrient absorption, and disposal of the insoluble products of heme catabolism. The synthesis and release of bile acids is tightly controlled and dependent on feedback mechanisms that regulate enterohepatic circulation. Alterations in bile composition, impaired gallbladder relaxation, and accelerated nucleation are the principal mechanisms leading to biliary stone formation. Read More

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http://dx.doi.org/10.1016/j.suc.2018.12.003DOI Listing
April 2019
2 Reads

An Update on Biliary Dyskinesia.

Authors:
Clancy J Clark

Surg Clin North Am 2019 Apr;99(2):203-214

General Surgery Residency, Center for Applied and Experiential Learning, Wake Forest Baptist Health, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Biliary dyskinesia is a functional disorder of the gallbladder or sphincter of Oddi. While cholecystectomy for symptomatic cholelithiasis is widely accepted, debate remains regarding the clinical benefit of invasive procedures for biliary dyskinesia. This article will review current best evidence in the diagnosis and management of biliary dyskinesia. Read More

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http://dx.doi.org/10.1016/j.suc.2018.11.004DOI Listing

Establishing and validating of an laboratory information system-based auto-verification system for biochemical test results in cancer patients.

J Clin Lab Anal 2019 Mar 6:e22877. Epub 2019 Mar 6.

Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: To establish and validate an laboratory information system (LIS)-based auto-verification (AV) system by using large amounts of biochemical test results in cancer patients.

Methods: An algorithm of the AV process was designed for pre-analysis, analysis, and post-analysis. The limit range check was adjusted three times, while the delta check criteria were first replaced by the same patients' historical extremum results. Read More

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http://dx.doi.org/10.1002/jcla.22877DOI Listing
March 2019
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More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.

Hell J Nucl Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Nuclear Medicine and PET/CT, Evangelismos General Hospital, Ypsilantou 45-47, PC 106 76, Athens, Greece.

Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Read More

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http://dx.doi.org/10.1967/s002449910952DOI Listing
March 2019
3 Reads

Safe laparoscopic cholecystectomy: Adoption of universal culture of safety in cholecystectomy.

World J Gastrointest Surg 2019 Feb;11(2):62-84

Transplant and HPB Surgery, the Iowa Clinic-Iowa Methodist Hospital, Des Moines, IA 50309, United States.

The incidence of biliary injury after laparoscopic cholecystectomy (LC) has shown a declining trend though it may still be twice that as with open cholecystectomy. Major biliary or vasculobiliary injury is associated with significant morbidity. As prevention is the best strategy, the concept of a culture of safe cholecystectomy has been recently introduced to educate surgeons and apprise them of basic tenets of safe performance of LC. Read More

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http://dx.doi.org/10.4240/wjgs.v11.i2.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397793PMC
February 2019
1 Read

A high monocyte-to-lymphocyte ratio predicts poor prognosis in patients with advanced gallbladder cancer receiving chemotherapy.

Cancer Epidemiol Biomarkers Prev 2019 Mar 6. Epub 2019 Mar 6.

Internal Medicine, Seoul National University College of Medicine.

Background: Monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been reported to be prognostic markers in various cancers. However, the prognostic value of these inflammatory biomarkers, particularly MLR, in gallbladder cancer remains to be determined.

Methods: From 2005 to 2016, 178 patients with histologically confirmed gallbladder adenocarcinoma who underwent palliative chemotherapy were queried in this study. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1066DOI Listing
March 2019
4 Reads

Left-sided gallbladder: a systematic review of a rare biliary anomaly.

ANZ J Surg 2019 Mar 5. Epub 2019 Mar 5.

The Whiteley-Martin Research Unit, Discipline of Surgery, The University of Sydney, Sydney, New South Wales, Australia.

Background: A left-sided gallbladder (LSGB) is a rare anatomical anomaly that is often not discovered until surgery. Two cases of LSGB managed with laparoscopic cholecystectomy (LC) stimulated this systematic review. The aims of this study were in LSGB to define the rate of pre-operative detection, variations in biliary anatomy, laparoscopic techniques employed and outcomes of surgery for symptomatic gallstones. Read More

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http://doi.wiley.com/10.1111/ans.15041
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http://dx.doi.org/10.1111/ans.15041DOI Listing
March 2019
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10-mm Laparo-Endoscopic Single-Site Cholecystectomy Using Multiple Magnetically Anchored and Controlled Instruments.

J Surg Res 2019 Mar 2;239:166-172. Epub 2019 Mar 2.

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Background: To study the feasibility of laparo-endoscopic single-site (LESS) cholecystectomy through a 10-mm incision using a miniature magnetically anchored and controlled laparoscopy system and a grasper system.

Methods: The miniature magnetically anchored and controlled laparoscopy system consisted of a miniature magnetically anchored camera (MMAC), an external magnetic anchoring unit, and a vision output device. The camera weighed 9. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.012DOI Listing

Cholecystocolic fistula diagnosis with hepatobiliary scintigraphy: A case report.

JGH Open 2019 Feb 1;3(1):91-93. Epub 2018 Nov 1.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

We report a 62-year-old woman who presented with chronic watery diarrhea and weight loss. During evaluation, she was found to have pneumobilia in the absence of gallstones, raising the suspicion of bilioenteric communication. Computed tomography demonstrated adherence of the gallbladder to the adjacent transverse colon. Read More

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http://dx.doi.org/10.1002/jgh3.12104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386746PMC
February 2019

Palliation of malignant gastroduodenal obstruction with self-expandable metal stent using side- and forward-viewing endoscope: Feasibility and outcome.

JGH Open 2019 Feb 19;3(1):65-70. Epub 2018 Nov 19.

Department of Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India.

Background: The endoscopic placement of a self-expandable metal stent (SEMS), an alternative to surgical bypass for the palliation of malignant gastric outlet obstruction (GOO), is commonly performed using a forward-viewing endoscope with a wide therapeutic channel; however, due to limited availability, most Indian centers use a side-viewing duodenoscope. We studied the feasibility and outcome of SEMS placement using side- and forward-viewing endoscopes.

Method: Data of patients undergoing SEMS placement using side- and forward-viewing endoscopes with a therapeutic channel for the palliation of malignant GOO presenting during a 5-year period were analyzed retrospectively. Read More

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http://dx.doi.org/10.1002/jgh3.12110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386745PMC
February 2019

Prognostic Role of Claudin-1 Immunohistochemistry in Malignant Solid Tumors: A Meta-Analysis.

J Pathol Transl Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Urology, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea.

Background: Although the correlation between low claudin-1 expression and worse prognosis has been reported, details on the prognostic implications of claudin-1 expression in various malignant tumors remain unclear. The present study aimed to elucidate the prognostic roles of claudin-1 immunohistochemistry (IHC) in various malignant tumors through a meta-analysis.

Materials And Methods: The study included 2,792 patients from 22 eligible studies for assessment of the correlation between claudin-1 expression and survival rate in various malignant tumors. Read More

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http://dx.doi.org/10.4132/jptm.2019.02.03DOI Listing
March 2019
2 Reads

Retrohepatic Gallbladder Masquerading as Hydatid Cyst in a Patient with Right Liver Agenesis.

Chirurgia (Bucur) 2019 Jan-Feb;114(1):121-125

Agenesis of the right liver is a rare congenital anomaly which can be associated with an ectopic gallbladder. Hereby, it is presented the case of a 39-year-old man investigated for right upper quadrant abdominal pain and diagnosed at computed tomography with a cystic liver mass initially considered as hydatid cyst. At laparotomy, it was discovered agenesis of the right liver and the presumed hydatid cyst was a retrohepatic gallbladder with lithiasis. Read More

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http://dx.doi.org/10.21614/chirurgia.114.1.121DOI Listing
February 2019

Asymptomatic malignant melanoma of the gallbladder with multiple brain metastases diagnosed with endoscopic ultrasound-guided fine-needle aspiration cytology.

Clin J Gastroenterol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, Fujimoto General Hospital, 17-1, Hayasuzu, Miyakonojo, Miyazaki, 885-0055, Japan.

Malignant melanoma of the gallbladder (MMG) is extremely rare and its early stage diagnosis is difficult. Most reports of MMG describe metastatic tumors. We herein report a rare case of presumed primary MMG diagnosed by endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) cytology without surgical resection. Read More

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http://dx.doi.org/10.1007/s12328-019-00957-zDOI Listing
March 2019
2 Reads