41,822 results match your criteria Gallbladder


Biliary tract cancer incidence and trends in the United States by demographic group, 1999-2013.

Cancer 2019 Jan 15. Epub 2019 Jan 15.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

Background: Biliary tract cancers (BTCs) are rare but deadly cancers (gallbladder cancer [GBC], intrahepatic cholangiocarcinoma [ICC], extrahepatic cholangiocarcinoma [ECC], and ampulla of Vater cancer [AVC]). A recent US study reported increasing GBC incidence among people younger than 45 years and blacks; however, it did not examine trends for other biliary tract sites.

Methods: This study characterized demographic differences in BTC incidence rates and time trends by anatomic site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.31942DOI Listing
January 2019

Laparoscopic cholecystectomy after endoscopic treatment of choledocholithiasis: a retrospective comparative study.

Updates Surg 2019 Jan 14. Epub 2019 Jan 14.

Department of General and Endoscopic Surgery, Hospital General Dr. Manuel Gea González, Calzada de Tlalpan 4800, Mexico City, 14090, Mexico.

Patients with combined choledocholithiasis and cholecystitis require treatment of both diseases. The aim of our study was to analyze perioperative results of next-day (< 24 h) vs. early (> 24 h) laparoscopic cholecystectomy (LC) after endoscopic clearance of common bile duct stones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13304-019-00624-5DOI Listing
January 2019

Successful Elimination of Gallbladder Ascariasis by Conservative Therapy, Followed by Cholecystectomy due to Developing Cholecystitis.

Case Rep Gastrointest Med 2018 10;2018:5831257. Epub 2018 Dec 10.

Gastroenterology Department, Faculty of Medicine, Aleppo University Hospital, University of Aleppo, Aleppo, Syria.

Background: is the most common parasitic infection in human. The worm is usually located in the small intestine, but may invade into the pancreatic or biliary tree, but rarely into gallbladder because of the anatomic features of the cystic duct.

Case Presentation: We report a case of gallbladder ascariasis that was diagnosed incidentally in a 70-year-old man, with negative ova and parasite test and no eosinophilia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/5831257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311234PMC
December 2018

[Effect of Shengqing Capsule on Serum Cholesterol Content and Hepatic Scavenger Receptor Class B of Rats with Cholesterol Calculus].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 Nov;36(11):1369-1372

Objective To observe the effect of Shengqing Capsule (SC) on serum contents of TC, LDL-C, and HDL-C, hepatic scavenger receptor B I (SRB I ) , and CD36 in rats with cholesterol cal- culus. Methods Totally 80 mice were divided into 4 groups according to random number table, i.e. Read More

View Article

Download full-text PDF

Source
November 2016

Cholangioscopy complicated by gallbladder perforation.

Gastrointest Endosc 2019 Jan 9. Epub 2019 Jan 9.

Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2019.01.007DOI Listing
January 2019

The heavy price of conversion from laparoscopic to open procedures for emergent cholecystectomies.

Am J Surg 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery, Howard University Hospital and College of Medicine, Washington, DC, USA. Electronic address:

Background: Laparoscopic cholecystectomy (LC) is the standard operative intervention for gallbladder disease. Complications may necessitate conversion to an open cholecystectomy (OC). This study aims to determine the cost-consequences of laparoscopic-to-open conversion using a nationally-representative sample. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2018.12.038DOI Listing
December 2018

Helicobacter infection in the hepatobiliary system and hepatic lesions: a possible association in dogs.

Braz J Microbiol 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Animal Pathology, School of Veterinary Medicine, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Km 380, Londrina, Parana, 86057-970, Brazil.

Helicobacter infection has been associated with hepatobiliary diseases in humans and animals. The aims of this study were to identify Helicobacter species in the hepatobiliary tract of dogs and to elucidate the possible association of these bacteria in liver diseases. Twenty-seven gastric and hepatobiliary samples were collected from 33 dogs with hepatic lesions and 17 dogs with no liver histological changes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42770-018-0003-8DOI Listing
December 2018

Xanthogranulomatous Oophoritis: A Rare Case Report.

Iran J Pathol 2018 12;13(3):372-376. Epub 2018 Sep 12.

Dept. of Pathology, Dayanand Medical College and Hospital, Ludhiana, India.

Xanthogranulomatous oophoritis is an uncommon, non-neoplastic, chronic process in which the affected organ is destroyed by massive cellular infiltration of foamy histiocytes admixed with multinucleated giant cells, plasma cells, fibroblasts, neutrophils, and foci of necrosis. The etiology of this entity is unknown, but it shares histopathological findings similar to those of xanthogranulomatous change occurring in various organs, including the gallbladder and kidney. The current case was a 20-year-old female presenting with a tubo-ovarian mass with suspicion of malignancy on clinicoradiological findings and final diagnosis of xanthogranulomatous oophritis established on histopathology. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322522PMC
September 2018

Safety of transarterial radioembolization with Yttrium-90 glass microspheres without cystic artery occlusion.

Radiol Med 2019 Jan 11. Epub 2019 Jan 11.

Department of Nuclear Medicine, Yeditepe University Hospital, 34752, Atasehir, Istanbul, Turkey.

Purpose: To assess radiation-induced cholecystitis in cases of cystic artery origin nearby the treatment zone for transarterial radioembolization (TARE) treatment.

Materials And Methods: Patients with primary or secondary malignant liver tumors treated with TARE, in whom cystic artery was located in the surrounding area of the treatment zone on 99m-technetium-MAA angiograms, were included in this study. Whole liver dose, tumor dose and healthy injected liver dose, lung dose and if applicable the gallbladder dose were all calculated by using the Medical Internal Radiation Dose (MIRD) formula from SPECT-CT images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11547-018-00984-9DOI Listing
January 2019

Gallbladder torsion: a cholecystectomy that cannot be delayed.

Acta Chir Belg 2019 Jan 11:1-3. Epub 2019 Jan 11.

a Department of Digestive Surgery , Université Libre de Bruxelles , Brussels , Belgium.

Gallbladder torsion is a rare entity, where the gallbladder twisted around its mesentery. Unfortunately, the diagnosis is rarely done preoperatively. This paper aims, through a case report, to describe the risk factors and the radiological criteria used to diagnose gallbladder torsion, in order to avoid a rapidly unfavourable evolution and the need to proceed to emergency cholecystectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00015458.2018.1553819DOI Listing
January 2019

Fetal phenotype of Rubinstein-Taybi syndrome caused by CREBBP mutations.

Clin Genet 2019 Jan 11. Epub 2019 Jan 11.

CHU Bordeaux, Service de Génétique Médicale, Bordeaux, France.

Rubinstein-Taybi syndrome (RSTS; OMIM 180849) is an autosomal dominant developmental disorder characterized by facial dysmorphism, broad thumbs and halluces associated with intellectual disability. RSTS is caused by alterations in CREBBP (about 60%) and EP300 genes (8%). RSTS is often diagnosed at birth or during early childhood but generally not suspected during antenatal period. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cge.13493
Publisher Site
http://dx.doi.org/10.1111/cge.13493DOI Listing
January 2019
1 Read

Management And Outcome Of Jaundice Secondary To Malignancies Of The Gall Bladder, Biliary Tree And Pancreas: A Single Centre Experience.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):571-575

Department of Gastroenterology & Hepatology, Shaikh Zayed Hospital, Lahore, Pakistan.

Background: Obstructive jaundice due to malignancies of the biliary tree, gall bladder and pancreas account for a significant number of patients managed by tertiary centres. Management options are curative or palliative, depending on disease stage. This study was performed to see the effectiveness of treatment modalities for these patients and eventual outcome. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Endoscopic Ultrasound-Guided Gallbladder Drainage for Aberrant Right Posterior Duct Obstruction Developing after Placement of a Covered Self-Expandable Metallic Stent in a Patient with Distal Biliary Obstruction.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):722-728. Epub 2018 Nov 28.

Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has been utilized as an alternative endoscopic technique for patients with acute cholecystitis. In addition to EUS-guided hepaticogastrostomy and EUS-guided cystogastrostomy, EUS-GBD has been reported as being useful for biliary drainage in cases with distal malignant biliary obstruction instead of conventional endoscopic retrograde cholangiopancreatography. We present a case of successful EUS-GBD for malignant obstruction of an aberrant hepatic duct draining directly into the cystic duct. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323387PMC
November 2018

Increased Prevalence of Pancreaticobiliary Maljunction in Biliary Malignancies.

Scand J Surg 2019 Jan 11:1457496918822617. Epub 2019 Jan 11.

1 Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Children's Hospital, University of Helsinki, Helsinki, Finland.

Aim:: The incidence of pancreaticobiliary maljunction is thought to approximate 1:100,000 within Western populations. We aimed to study the significance of pancreaticobiliary maljunction in biliary tract malignancies.

Methods:: Medical records and magnetic resonance cholangiopancreatography images of 252 consecutive patients treated for biliary malignancies during 2005-2016 were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1457496918822617DOI Listing
January 2019

Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice.

J Ethnopharmacol 2019 Jan 7. Epub 2019 Jan 7.

Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan-city, Gyeongnam, 50612, South Korea.

Ethnopharmacological Relevance: The roots and rhizomes of Gentiana scabra Bunge in the family Gentianaceae comprise a major herbal medicine for skin diseases caused by wind-heat or dampness-heat in China, Japan and Korea. This treatment can clear away heat and dry dampness and purge fire from the liver and gallbladder.

Aim Of The Study: This study was designed to investigate the therapeutic potential and anti-inflammatory effects of G. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741173330
Publisher Site
http://dx.doi.org/10.1016/j.jep.2018.12.046DOI Listing
January 2019
3 Reads

Knowledge-aided Convolutional Neural Network for Small Organ Segmentation.

IEEE J Biomed Health Inform 2019 Jan 9. Epub 2019 Jan 9.

Accurate and automatic organ segmentation is critical for computer-aided analysis towards clinical decision support and treatment planning. State-of-the-art approaches have achieved remarkable segmentation accuracy on large organs such as the liver and kidneys. However, most of these methods do not perform well on small organs such as the pancreas, gallbladder and adrenal glands, especially when lacking sufficient training data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/JBHI.2019.2891526DOI Listing
January 2019

Association between metabolic syndrome and hepatobiliary cancers: A case-control study.

Indian J Gastroenterol 2019 Jan 10. Epub 2019 Jan 10.

The Royal Wolverhampton NHS Trust, Wolverhampton, UK.

Background: The incidence of hepatobiliary cancer is steadily increasing. It is unclear if this rise is related to increasing trends in obesity, metabolic syndrome, and lifestyle changes.

Methods: A case-control study was performed using the Health Improvement Network (THIN) database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12664-018-0925-yDOI Listing
January 2019

Factors Associated with Malignant Biliary Strictures in Patients with Atypical or Suspicious Cells on Brush Cytology.

Clin Endosc 2019 Jan 9. Epub 2019 Jan 9.

Division of Gastroenterology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Background/aims: Pathological diagnosis of biliary strictures with atypical or suspicious cells on endoscopic retrograde brush cytology and indeterminate strictures on imaging is challenging. The aim of this study was to identify markers for malignant strictures in such cases.

Methods: We retrospectively analyzed data collected from 146 consecutive patients with indeterminate biliary strictures on imaging who underwent endoscopic retrograde brush cytology from 2007 to 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5946/ce.2018.105DOI Listing
January 2019

Efficacy and Safety of Hou Gu Mi Xi on Spleen Qi Deficiency in Patients with Nonorganic Gastrointestinal Disorders: Protocol for a Multicenter, Randomized, Placebo-Controlled Trial.

Evid Based Complement Alternat Med 2018 2;2018:1980491. Epub 2018 Dec 2.

Evidence-Based Medicine Research Center, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Jiangxi, China.

Background: There is a worldwide epidemic of nonorganic gastrointestinal disorders (NOGDs), which are a class of disorders that cause various discomforts and ultimately progress into organic gastrointestinal diseases. Because of the unsatisfactory efficacy of Western medical treatments, traditional Chinese medicine (TCM) is becoming a promising complementary and alternative treatment to manage NOGDs.

Objectives: To investigate the efficacy and safety of Hou Gu Mi Xi (HGMX), a newly developed dietary TCM formula, on the syndrome of spleen qi deficiency (SQD) in patients with NOGDs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/1980491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304527PMC
December 2018

Laparoscopic management of intra-hepatic gallbladder perforation.

J Minim Access Surg 2019 Jan 4. Epub 2019 Jan 4.

Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India.

Intra-hepatic perforation of the gallbladder (GB) leading to hepatic abscess is a serious and rare complication of cholecystitis, with very few sporadically reported cases in the literature. Hence, there is no standard approach to treat it. A thorough radiological evaluation with computed tomography and endoscopic retrograde cholangiopancreatography is necessary before proceeding with surgery in such cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jmas.JMAS_267_18DOI Listing
January 2019
2 Reads

Magnetic resonance imaging-guided three-dimensional real-time bile duct reconstruction and end-to-end anastomosis under laparoscopy: A case report.

J Minim Access Surg 2019 Jan 4. Epub 2019 Jan 4.

Department of Hepato-Biliary-Pancreatic Surgery, Taipei Medical University Ningbo Medical Centre, Ningbo, China.

In laparoscopic cholecystectomy (LC), the anatomical variation of gallbladder canal should be noted. Bile duct injury is one of the most serious complications of LC, which might lead to serious complications. This case because of an intraoperative accidental cut to right anterior inferior lobe bile duct which joins to the cystic duct, after confirming by intraoperative magnetic resonance imaging-guided real-time three-dimensional bile duct reconstruction and performing end-to-end anastomosis of the right anterior inferior lobe bile duct and the gallbladder tube under laparoscopy, the patient was discharged 5 days after surgery, was followed up for 4 months and was disease-free. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jmas.JMAS_242_18DOI Listing
January 2019
1 Read

Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study.

World J Surg Oncol 2019 Jan 7;17(1). Epub 2019 Jan 7.

Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of Medicine, 79, Gangnam-ro, Jinju, 660-702, South Korea.

Background: While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC.

Methods: Data of 81 patients with histopathologically proven T2 GBC who underwent surgical resection between January 1999 and December 2017 were enrolled from a retrospective database. Read More

View Article

Download full-text PDF

Source
https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
Publisher Site
http://dx.doi.org/10.1186/s12957-018-1556-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323785PMC
January 2019
1 Read

Randomized Trial of Near-infrared Incisionless Fluorescent Cholangiography.

Ann Surg 2019 Jan 9. Epub 2019 Jan 9.

Department of General Surgery, Cleveland Clinic Florida, Weston, FL.

Background: Incisionless near-infrared fluorescent cholangiography (NIFC) is emerging as a promising tool to enhance the visualization of extrahepatic biliary structures during laparoscopic cholecystectomies.

Methods: We conducted a single-blind, randomized, 2-arm trial comparing the efficacy of NIFC (n = 321) versus white light (WL) alone (n = 318) during laparoscopic cholecystectomy. Using the KARL STORZ Image1 S imaging system with OPAL1 technology for NIR/ICG imaging, we evaluated the detection rate for 7 biliary structures-cystic duct (CD), right hepatic duct (RHD), common hepatic duct, common bile duct, cystic common bile duct junction, cystic gallbladder junction (CGJ), and accessory ducts -before and after surgical dissection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SLA.0000000000003178DOI Listing
January 2019
5 Reads

Modulation on gallbladder carcinoma by TGF-β1 via IGFBP-2.

Cancer Biomark 2018 Dec 26. Epub 2018 Dec 26.

Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430000, China.

Gallbladder carcinoma (GC) occupies more than 90% of all cancers in biliary tract with an increasing incidence. Most patients with GC are already at terminal stage at the time of primary diagnosis, causing unfavorable prognosis and high mortality. Transformation growth factor-beta (TGF-β) is up-regulated in GC. Read More

View Article

Download full-text PDF

Source
https://www.medra.org/servlet/aliasResolver?alias=iospress&a
Publisher Site
http://dx.doi.org/10.3233/CBM-181895DOI Listing
December 2018
1 Read
1.186 Impact Factor

Bile Duct Hamartoma Mimicking Liver Metastasis in Suspected Porcelain Gallbladder: a Case Report.

J Gastrointest Cancer 2019 Jan 6. Epub 2019 Jan 6.

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12029-018-00198-2DOI Listing
January 2019

KML001, an arsenic compound, as salvage chemotherapy in refractory biliary tract cancers: A prospective study.

Hepatobiliary Pancreat Dis Int 2018 Dec 28. Epub 2018 Dec 28.

Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Electronic address:

Background: Sodium meta-arsenite (NaAsO, KML001) is a potential oral anticancer agent acting on telomerase and telomere length. This prospective study evaluated its safety, tolerability, and effectiveness as salvage chemotherapy in patients with advanced biliary tract cancer (BTC) resistant to gemcitabine-based chemotherapy.

Methods: Forty-four patients (21 women and 23 men) with advanced BTC and failure history of gemcitabine-based chemotherapy, performance status (PS) 0-2, normal cardiac, hepatic, and renal function were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hbpd.2018.12.009DOI Listing
December 2018

Anticoagulants is a risk factor for spontaneous rupture and hemorrhage of gallbladder: a case report and literature review.

BMC Surg 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Background: The spontaneous rupture of the gallbladder is extremely rare, majority of ruptures occur secondary to traumatic injuries. Here, we report a case of spontaneous rupture of the gallbladder with probably cause of oral anticoagulants.

Case Presentation: A 51-year-old woman presented to the emergency room with sudden-onset severe abdominal pain, as well as hypotension and low level of hemoglobin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12893-018-0464-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321697PMC
January 2019

Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin.

BMC Cancer 2019 Jan 5;19(1):10. Epub 2019 Jan 5.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.

Background: Gallbladder cancer (GBC) is likely to be diagnosed at progressive stages and shows a very poor prognosis. Combination therapy with gemcitabine and cisplatin (GEMCIS) has been widely used as first-line palliative chemotherapy for advanced GBC. This study was designed to investigate the efficacy of GEMCIS and identify prognostic factors in patients with unresectable GBC. Read More

View Article

Download full-text PDF

Source
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-018-5211-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321682PMC
January 2019
2 Reads

Neuroendocrine carcinomas of the gallbladder: Lessons learnt from cases at opposite ends of the spectrum.

J BUON 2018 Nov-Dec;23(6):1922-1926

Department of Surgery, Duke University Hospital, Durham, NC, USA.

Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which represents about 0.5% of all gallbladder carcinomas and 0. Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Roles of Pin1 as a Key Molecule for EMT Induction by Activation of STAT3 and NF-κB in Human Gallbladder Cancer.

Ann Surg Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: Despite developments in multidisciplinary treatment, the prognosis for advanced gallbladder cancer (GBC) still is poor because of its rapid progression. Epithelial-mesenchymal transition (EMT) plays a central role in promoting tumor invasion and metastasis in malignancies thorough signal transducer and activator of transcription-3 (STAT3) and nuclear factor κB (NF-κB) activation. Whereas Pin1 mediates STAT3 and NF-κB activation, the involvement of Pin1 in GBC progression is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-018-07132-7DOI Listing
January 2019
5 Reads

Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids.

J Lipid Res 2019 Jan 4. Epub 2019 Jan 4.

Karolinska Institutet, Sweden.

Gallstone formation requires that bile is supersaturated with cholesterol, estimated by a cholesterol saturation index (CSI) calculated from gallbladder total lipids and the mol % bile acids, cholesterol and phospholipids. Whereas CSI indicates gallstone risk, we hypothesized that additional comparisons of gallbladder lipid mol % data are inappropriate to identify why CSI is increased in gallstone disease. We anticipated gallbladder lipid mmol/L levels should instead identify that and therefore retrieved gallbladder mmol/L data for bile acids, cholesterol and phospholipids from a study on 145 gallstone and 87 gallstone-free patients and compared them with the corresponding mol % data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.S091199DOI Listing
January 2019

Genetics of gallstone disease revisited: updated inventory of human lithogenic genes.

Curr Opin Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Purpose Of Review: Gallstone disease is one of the most frequent diseases in gastroenterology and treatment by endoscopy and surgery causes high costs in our health-care systems. Family and twin studies have demonstrated that gallstones are, in part, genetically determined. Here we review all recent genome-wide and phenome-wide studies of gallstones in humans and provide an updated 'inventory of human lithogenic genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOG.0000000000000511DOI Listing
January 2019

3D printing-Based strategies for functional cartilage regeneration.

Tissue Eng Part B Rev 2019 Jan 4. Epub 2019 Jan 4.

Chinese PLA General Hospital, Institute of Orthopaedics , 28 Fuxing Road, Haidian District, Beijing, People's Republic of China , Beijing, China , 100853 ;

The regeneration of cartilage has made great progress in the past few decades, Previous techniques for constructing tissue-engineered cartilage scaffolds mainly include particulate-leaching, gas-foaming, freeze-drying and phase-separation techniques. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate such anisotropy. Therefore, the functional regeneration of cartilage is challenging. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/ten.TEB.2018.0248
Publisher Site
http://dx.doi.org/10.1089/ten.TEB.2018.0248DOI Listing
January 2019
1 Read

[Report of incidence and mortality of gallbladder cancer in China, 2014].

Zhonghua Zhong Liu Za Zhi 2018 Dec;40(12):894-899

the Project Office of Early Detection and Treatment of Cancer in Urban China, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

The incidence and mortality of gallbladder cancer from Chinese cancer registries in 2014 were analyzed to describe the prevalence of gallbladder cancer in China. Incidence and mortality data of gallbladder cancer in 2014 derived from registration data in 2017, collected by the National Central Cancer Registry (NCCR). Qualified data from 339 cancer registries were calculated after evaluating. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.12.004DOI Listing
December 2018
3 Reads

In vitro effect of 20% N-acetylcysteine on the viscosity of normal canine bile.

Am J Vet Res 2019 Jan;80(1):74-78

OBJECTIVE To evaluate the in vitro effect of 20% N-acetylcysteine (NAC) on the viscosity of normal canine bile. ANIMALS Bile samples obtained from 10 adult dogs euthanized for reasons unrelated to biliary disease. PROCEDURES Each sample was centrifuged to remove particulates, then divided into 3 aliquots. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2460/ajvr.80.1.74DOI Listing
January 2019

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.

Am J Physiol Gastrointest Liver Physiol 2019 Jan 3. Epub 2019 Jan 3.

Ardelyx, Inc., United States.

TGR5 agonists induce systemic release of glucagon-like peptides (GLPs) from intestinal L-cells, a potentially therapeutic action against metabolic diseases like non-alcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Historically, TGR5 agonist use has been hindered by side effects including inhibition of gallbladder emptying. Here, we characterize RDX8940, a novel, orally administered TGR5 agonist designed to have minimal systemic effects, and investigate its activity in mice fed a Western diet, a model of NAFLD and mild insulin resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00300.2018DOI Listing
January 2019
3.798 Impact Factor

Percutaneous cholecystostomy-tube for high-risk patients with acute cholecystitis: current practice and implications for future research.

Surg Endosc 2019 Jan 2. Epub 2019 Jan 2.

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, 2nd floor, Columbus, OH, USA.

Background: While cholecystectomy (CCY) is the standard of care for gallstone-related acute cholecystitis, percutaneous cholecystostomy-tube (CCYT-tube) is an alternative option in patients with significant comorbid conditions. We sought to identify immediate and longitudinal hospital outcomes of patients who underwent CCYT-tube placement and determine predictors of CCYT-tube placement and eventual CCY on a national level in the US.

Methods: We identified all adults (age ≥ 18 years) with a primary diagnosis of acute calculous cholecystitis from January to November 2013 in the Nationwide Readmissions Database (NRD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-018-06634-5DOI Listing
January 2019
3.256 Impact Factor

An autopsy case of primary extranodal NK/T cell lymphoma (extranodal NK/T-cell lymphoma) of the bile duct.

Clin J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology, Tokai University Hachioji Hospital, Tokyo, Japan.

We reported the case of a 50-year-old man diagnosed with extrinsic NK/T-cell lymphoma. He was initially diagnosed with locally advanced unresected pancreatic duct carcinoma and was treated with combination chemotherapy using gemcitabine and nabpaclitaxel. One month after treatment, he developed bleeding. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12328-018-00931-1
Publisher Site
http://dx.doi.org/10.1007/s12328-018-00931-1DOI Listing
January 2019
4 Reads

Multiseptate Gallbladder in a Child: A Possible Cause of Poor Growth?

J Pediatr Gastroenterol Nutr 2019 Jan;68(1):e13

Section of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005176-900000000-9712
Publisher Site
http://dx.doi.org/10.1097/MPG.0000000000001664DOI Listing
January 2019
1 Read

The "expanded gallbladder fossa sign" in liver cirrhosis.

Abdom Radiol (NY) 2019 Jan 1. Epub 2019 Jan 1.

Radiology Unit, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Via Tricomi 5, 90127, Palermo, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00261-018-1878-4DOI Listing
January 2019

Mechanical strength of biliary defect closure after topical sealing: Comparison of four sealants in a porcine model.

Asian J Surg 2018 Dec 29. Epub 2018 Dec 29.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany. Electronic address:

Background/objective: Biliary leakage is a potential complication of liver resection and is still a concern. The aim of the present study was to evaluate the effectiveness of four routinely used sealants in preventing bile leakage under pressure from an induced perforation of the gallbladder in a porcine model.

Methods: Forty Landrace pigs were randomly assigned to one of five groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.asjsur.2018.11.009DOI Listing
December 2018

The diagnostic accuracy of CT and MRI for the detection of lymph node metastases in gallbladder cancer: A systematic review and meta-analysis.

Eur J Radiol 2019 Jan 28;110:156-162. Epub 2018 Nov 28.

Department of Surgery, Radboud University Medical Centre, Nijmegen, P.O. Box 9101, 6500HB, the Netherlands.

Background: Lymph node metastases (LNM) are an ominous prognostic factor in gallbladder cancer (GBC) and, when present, should preclude surgery. However, uncertainty remains regarding the optimal imaging modality for pre-operative detection of LNM and international guidelines vary in their recommendations. The purpose of this study was to systematically review the diagnostic accuracy of computed tomography (CT) versus magnetic resonance imaging (MRI) in the detection of LNM of GBC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejrad.2018.11.034DOI Listing
January 2019

Negotiating the Curve of Laparoscopic Hepatopancreaticobiliary Procedures (Basic to Advanced) at a Tertiary Rural Teaching Institute.

Int J Appl Basic Med Res 2018 Oct-Dec;8(4):237-243

Department of Anesthesia, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background: We present here our experience of laparoscopic hepatopancreaticobiliary (HPB) surgeries at our rural institute and the hurdles we faced overcoming the various challenges.

Aims And Objectives: The objectives of this study were to assess the feasibility, successful completion, operative time, conversions/requirement of assistance, duration of hospital stay, and postoperative complications on the HPB procedures performed laparoscopically in our surgical unit; and to help young surgeons for smooth navigation through their laparoscopic career.

Materials And Methods: All the patients admitted under our unit over the past 9 years for elective HPB surgeries operated by a single surgeon were included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijabmr.IJABMR_399_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259292PMC
January 2019
1 Read

A duplicated Gallbladder in a Patient Presenting with Acute Cholangitis. A Case Study and a Literature Review.

Ann Hepatol 2018 Dec;18(1):240-245

2nd Dept. of Surgery, "Aretaieio" Hospital, National and Kapodistrian University of Athens, School of Medicine, Greece.

Gallbladder duplication can present a clinical challenge primarily due to difficulties with diagnosis and identification. Recognition of this anomaly and its various types is important since it can complicate a gallbladder disease or a simple hepatobiliary surgical procedure. The case report of a 63-year-old woman who presented with cholangitis and underwent a successful laparoscopic management of symptomatic gallbladder duplication is described, emphasizing several important considerations. Read More

View Article

Download full-text PDF

Source
https://annalsofhepatology.publisherspanel.com/gicid/01.3001
Publisher Site
http://dx.doi.org/10.5604/01.3001.0012.7932DOI Listing
December 2018
6 Reads

Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 25;2018:6124927. Epub 2018 Nov 25.

Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Orthopaedic Department, China-Japan Friendship Hospital, Chaoyang District, Beijing, China.

Background: Previous literatures have investigated the change of miR-20a expression level in the progression of multiple cancers and its influence on patients' survival outcome, but results of now-available evidence are inconsistent.

Objective: To elucidate the prognostic value of circulating and tissue-based miR-20a for patients with various cancers.

Methods: A systematic search and review of eligible publications were carried out in three electronic databases including the Cochrane Library, PubMed, and Embase, and the methodological quality of included studies was assessed according to Newcastle-Ottawa Scale (NOS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/6124927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286746PMC
November 2018
4 Reads

Laparoscopic treatment of a solitary fibrous tumor originating in the cystic plate.

Surg Case Rep 2018 Dec 29;4(1):150. Epub 2018 Dec 29.

Department of Surgery, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.

Background: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor originating from the tissue underlying the mesothelial layer of the pleura or mediastinum. Other reported sites include the upper respiratory tract, orbit, thyroid, peritoneum, and central nervous system.

Case Presentation: We describe a case of a 7 cm SFT that originated in the cystic plate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-018-0556-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311172PMC
December 2018

Ectopic relapse of IgG4-related disease presenting as IgG4-related sclerosing cholecystitis: A case report and review of literature.

Medicine (Baltimore) 2018 Dec;97(52):e13868

Department of Gastroenterology and Hepatology.

Rationale: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a chronic inflammatory disorder characterized by high levels of serum IgG4, swollen organs with fibrosis and abundant infiltration of IgG4-positive plasmacytes.

Patient Concerns: An 82-year-old male visited our hospital for an evaluation of a pancreatic enlargement and a bilateral submandibular adenopathy. Further investigation revealed elevation of serum IgG4 and bilateral lacrimal submandibular adenopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000013868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314772PMC
December 2018
8 Reads

Gastrointestinal defects in gallstone and cholecystectomized patients.

Eur J Clin Invest 2018 Dec 28:e13066. Epub 2018 Dec 28.

Clinica Medica "A. Murri", Department of Biomedical Sciences& Human Oncology, University of Bari Medical School, Bari, Italy.

Background And Aim: Several gallstone patients complain of dyspeptic symptoms, irrespective of the presence of typical colicky pain. Symptoms often persist after a cholecystectomy. Systematic studies on dyspepsia and dynamic gastrointestinal motor function are missing in gallstone patients with preserved gallbladder or after a cholecystectomy. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/eci.13066
Publisher Site
http://dx.doi.org/10.1111/eci.13066DOI Listing
December 2018
1 Read

A unique case of xanthogranulomatous cholecystitis complicated by multiple liver abscesses and portal vein and hepatic artery thrombosis and occlusion.

J Surg Case Rep 2018 Dec 21;2018(12):rjy337. Epub 2018 Dec 21.

Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, 18099 Lorain Avenue Suite #108, Cleveland, OH, USA.

Xanthogranulomatous cholecystitis (XGC) is difficult to diagnose preoperatively because it often mimics gallbladder cancer. We present a case of a 64-year-old Caucasian male who presented with multiple intrahepatic abscesses, left portal vein and segmental right hepatic arterial thrombosis suspicious for extrahepatic cholangiocarcinoma who ultimately underwent an extended left hepatectomy and was noted to have XGC on final pathology. This case presents a new challenge in diagnosing XGC prior to final pathology results given the unique left portal vein, and later, right anterior portal vein thrombosis and occlusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jscr/rjy337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302241PMC
December 2018
1 Read

Building a bigger tent in point-of-care ultrasound education: a mixed-methods evaluation of interprofessional, near-peer teaching of internal medicine residents by sonography students.

BMC Med Educ 2018 Dec 27;18(1):321. Epub 2018 Dec 27.

Department of Medical Imaging & Therapeutic Sciences, Diagnostic Medical Sonography Program, University of Nebraska Medical Center, 984545 Nebraska Medical Center, Omaha, NE, 68198-4545, USA.

Background: Point-of-care-ultrasound (POCUS) training is expanding in undergraduate and graduate medical education, but lack of trained faculty is a major barrier. Two strategies that may help mitigate this obstacle are interprofessional education (IPE) and near-peer teaching. The objective of this study was to evaluate a POCUS course in which diagnostic medical sonography (DMS) students served as near-peer teachers for internal medicine residents (IMR) learning to perform abdominal sonography. Read More

View Article

Download full-text PDF

Source
https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909
Publisher Site
http://dx.doi.org/10.1186/s12909-018-1437-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307233PMC
December 2018
3 Reads