749,278 results match your criteria Future Virology[Journal]


Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

View Article
December 2018
1 Read

Predictive Value of Preoperative Magnetic Resonance Imaging Findings for Survival and Local Recurrence in Patients Undergoing En Bloc Resection of Sacral Chordomas.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Few studies have assessed the prognostic importance of preoperative magnetic resonance imaging (MRI) scan findings in patients undergoing en bloc resection of sacral chordomas.

Objective: To (1) report in-depth imaging characteristics of sacral chordomas, (2) describe the patterns of local and distant recurrence, and (3) determine imaging predictors of overall survival (OS) and local recurrence (LR).

Methods: This retrospective case series was obtained from a prospectively maintained spine database from 1995 to 2016. Read More

View Article
December 2018

A coordinate-based meta-analysis comparing brain activation between ADHD and total sleep deprivation.

Sleep 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Study Objectives: Sleep disruption is common in attention-deficit-hyperactivity-disorder (ADHD). Likewise, deficits in attention are a hallmark of sleep deprivation in healthy individuals. Whether ADHD and sleep deprivation modulate common, or disparate, neural systems is unknown. Read More

View Article
December 2018

Functionally distinct assembly of vascular plants colonizing alpine cushions suggests their vulnerability to climate change.

Ann Bot 2018 Dec 12. Epub 2018 Dec 12.

Institute of Botany, The Czech Academy of Sciences, Průhonice, Czech Republic.

Background And Aims: Alpine cushion plants can initially facilitate other species during ecological succession, but later on can be negatively affected by their development, especially when beneficiaries possess traits allowing them to overrun their host. This can be reinforced by accelerated warming favouring competitively strong species over cold-adapted cushion specialists. However, little empirical research has addressed the trait-based mechanisms of these interactions. Read More

View Article
December 2018
1 Read

Cumulative live birth rate prognosis based on the number of aspirated oocytes in previous ART cycles.

Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.

Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?

Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.

What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More

View Article
December 2018
1 Read

TNM classification of malignant tumors (Breast Cancer Study Group).

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

The eighth editions of the primary tumor, lymph node and metastasis classifications for breast cancer issued by the American Joint Commission of Cancer and the Union for International Cancer Control were revised in 2017. The major change made by the American Joint Commission of Cancer is to incorporate biological factors such as estrogen and progesterone receptor, human epidermal growth factor receptor 2, histological grade and multigene prognostic assays, into the staging system. Tumor biomarkers and low recurrence scores confirmed by multigene prognostic assays change the staging. Read More

View Article
December 2018

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Population Health Sciences, University of Bristol, Bristol, UK.

Background: Accumulating evidence suggests that breastfeeding benefits children's intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial. Read More

View Article
December 2018
1 Read

Electroluminescence of intrashell transitions in Eu doped single ZnO nanowires.

Nanotechnology 2018 Dec 12. Epub 2018 Dec 12.

Institute for Solid State Physics, Friedrich-Schiller Universitat Jena, Max-Wien-Platz 1, D-07743 Jena, Jena, GERMANY.

Tunable nanoscale light emitters are essential to accomplish future multifunctional optoelectronic nano-devices. Here, we present an approach for achieving red electroluminescence from single ZnO nanowires implanted with Europium ions. The electroluminescence is emitted mainly from the end facets of ZnO nanowires at room temperature under the application of an AC voltage. Read More

View Article
December 2018

Screening-Based Chemical Approaches to Unravel Stem Cell Biology.

Authors:
Shuibing Chen

Stem Cell Reports 2018 Dec;11(6):1312-1323

Department of Surgery and Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

Cell-permeable compounds provide a convenient and efficient approach to manipulate biological processes. A number of compounds controlling stem cell self-renewal, survival, differentiation, and reprogramming have been identified through high-throughput/content screens. Using these powerful chemical tools, strategies have been developed to direct human pluripotent stem cell (hPSC) differentiation to functional cells. Read More

View Article
December 2018

Electroluminescence Generation in PbS Quantum Dot Light Emitting Field Effect Transistors with Solid State Gating.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

The application of light emitting field effect transistors (LEFET) is an elegant way of combining electrical switching and light emission in a single device architecture instead of two. This allows for a higher degree of miniaturisation and integration in future opto-electronic applications. Here, we report on a LEFET based on lead sulphide quantum dots processed from solution. Read More

View Article
December 2018

Common Terminology and Acoustic Measures for Human Voice and Birdsong.

J Speech Lang Hear Res 2018 Dec 11:1-10. Epub 2018 Dec 11.

Department of Neuroscience, University of Arizona, Tucson.

Purpose: The zebra finch is used as a model to study the neural circuitry of auditory-guided human vocal production. The terminology of birdsong production and acoustic analysis, however, differs from human voice production, making it difficult for voice researchers of either species to navigate the literature from the other. The purpose of this research note is to identify common terminology and measures to better compare information across species. Read More

View Article
December 2018
1 Read

Gene network analysis of poplar root transcriptome in response to drought stress identifies a PtaJAZ3PtaRAP2.6-centered hierarchical network.

PLoS One 2018 12;13(12):e0208560. Epub 2018 Dec 12.

Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI, United States of America.

Using time-series transcriptomic data from poplar roots undergoing polyethylene glycol (PEG)-induced drought stress, we built a genetic network model of the involved putative molecular responses. We found that the network resembled a hierarchical structure. The highest hierarchical level in this structure is occupied by 9 genes, which we called superhubs because they were primarily connected to 18 hub genes, which are then connected to 2,934 terminal genes. Read More

View Article
December 2018

Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study.

PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.

Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More

View Article
December 2018

Decoupling environmental effects and host population dynamics for anthrax, a classic reservoir-driven disease.

PLoS One 2018 12;13(12):e0208621. Epub 2018 Dec 12.

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.

Quantitative models describing environmentally-mediated disease transmission rarely focus on the independent contribution of recruitment and the environment on the force of infection driving outbreaks. In this study we attempt to investigate the interaction between external factors and host's population dynamics in determining the outbreaks of some indirectly transmitted diseases. We first built deterministic and stochastic compartmental models based on anthrax which were parameterized using information from literature and complemented with field observations. Read More

View Article
December 2018

On the use of local weather types classification to improve climate understanding: An application on the urban climate of Toulouse.

PLoS One 2018 12;13(12):e0208138. Epub 2018 Dec 12.

Université Toulouse Jean Jaurès, Laboratoire Interdisciplinaire Solidarités Societés Territoires (LISST), Toulouse II University. 5, Toulouse, France.

This paper proposes a method based on a local weather type classification approach to facilitate analysis and communication of climate information in local climate studies. Presented herein is an application to urban climatology in Toulouse, France, but the method can be used in other applied fields of climatology as well. To describe the climatic context of this urbanized area, the local weather types that explain the plurality of weather situations Toulouse faces are presented in depth. Read More

View Article
December 2018

Computerization and the future of primary care: A survey of general practitioners in the UK.

PLoS One 2018 12;13(12):e0207418. Epub 2018 Dec 12.

General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States of America.

Objective: To describe the opinions of British general practitioners regarding the potential of future technology to replace key tasks carried out in primary care.

Design: Cross sectional online survey.

Participants: 1,474 registered GPs in the United Kingdom. Read More

View Article
December 2018
1 Read

Use of RFID technology to characterize feeder visitations and contact network of hummingbirds in urban habitats.

PLoS One 2018 12;13(12):e0208057. Epub 2018 Dec 12.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America.

Despite the popular use of hummingbird feeders, there are limited studies evaluating the effects of congregation, sharing food resources and increased contact when hummingbirds visit feeders in urban landscapes. To evaluate behavioral interactions occurring at feeders, we tagged 230 individuals of two species, Anna's and Allen's Hummingbirds, with passive integrated transponder tags and recorded their visits with RFID transceivers at feeders. For detecting the presence of tagged birds, we developed an RFID equipped feeding station using a commercially available antenna and RFID transceiver. Read More

View Article
December 2018

Geolocator deployment reduces return rate, alters selection, and impacts demography in a small songbird.

PLoS One 2018 12;13(12):e0207783. Epub 2018 Dec 12.

Department of Environmental Sciences, University of Toledo, Toledo, OH, United States of America.

In the past few years, miniature light-level geolocators have been developed for tracking wild bird species that were previously too small to track during their full annual cycle. Geolocators offer an exciting opportunity to study the full annual cycle for many species. However, the potential detrimental effects of carrying geolocators are still poorly understood, especially for small-bodied birds. Read More

View Article
December 2018

Susceptibility and resilience to cyber threat: Findings from a scenario decision program to measure secure and insecure computing behavior.

PLoS One 2018 12;13(12):e0207408. Epub 2018 Dec 12.

Department of Human Development and Family Studies, Iowa State University, Ames, Iowa, United States of America.

Interest in the individual differences underlying end user computer security behavior has led to the development of a multidisciplinary field of research known as behavioral information security. An important gap in knowledge and the motivation for this research is the development of ways to measure secure and insecure cyber behavior for research and eventually practice. Here we report a study designed to develop a technique for assessing secure and insecure cyber behavior for broad research use. Read More

View Article
December 2018

Social and ecological conditions of cranberry production and climate change attitudes in New England.

PLoS One 2018 12;13(12):e0207237. Epub 2018 Dec 12.

Earth and Environmental Sciences, Boston College, Chestnut Hill, Massachusetts, United States of America.

Cranberry growers in New England are increasingly pressured by negative effects associated with global climate change, some of which are familiar to this group (such as precipitation fluctuations and pest pressures), others that are rather new (such as warmer winters that threaten needed chill hours for the plants to bloom). The first study of this population of its kind, we use a survey, supplemented with observations and interviews, to assess Massachusetts cranberry grower attitudes towards climate change, and whether certain conditions of production might be associated with their attitudes. Our findings suggest that certain personal and ecological conditions are associated with greater worry of climate change effects, and that communal conditions of the cranberry grower social network provide some ways to cope with a warming climate. Read More

View Article
December 2018

Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Department of Biotechnology, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain.

Background And Objectives: Breast milk contains several bioactive factors including human milk oligosaccharides (HMOs) and microbes that shape the infant gut microbiota. HMO profile is determined by secretor status; however, their influence on milk microbiota is still uncovered. This study is aimed to determine the impact of the FUT2 genotype on the milk microbiota during the first month of lactation and the association with HMO. Read More

View Article
December 2018
1 Read

Differential Gene Expression in Erlotinib-treated Fibroblasts.

Nurs Res 2018 Dec 12. Epub 2018 Dec 12.

Assistant Professor, University of South Carolina, College of Nursing, Columbia, SC Bioinformatics Analyst I, University of Maryland, Baltimore, School of Medicine, Institute for Genome Sciences, Baltimore, MD Professor, Chair, Department of Hematology/Oncology, Deputy Director of the Cancer Center for Clinical Research, G. Morris Dorrance Chair in Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA Bioinformatics Analyst II, University of Maryland, School of Medicine, Institute for Genome Sciences, Baltimore, MD Laboratory Research Technician, University of Maryland, Baltimore, School of Nursing, Baltimore, MD Professor, Chair, Department of Pain and Translational Symptom Science, University of Maryland, Baltimore, School of Nursing, Baltimore, MD.

Background: Therapies targeting the epidermal growth factor receptor (EGFR) result in a painful rash, the most common and debilitating toxicity among patients with non-small cell lung cancer (NSCLC) who take EGFR tyrosine kinase inhibitor (TKI) therapy; however, predicting the development and the severity of the rash is difficult.

Objective: To examine how erlotinib-an EGFR TKI that NSCLC patients take to stop or slow tumor growth-altered the transcriptome of dermal fibroblasts.

Methods: Dermal fibroblasts (ATCC® PCS-201-012™) were seeded in cell culture flasks, grown under standard conditions, and transferred to cell culture dishes. Read More

View Article
December 2018

Factors Predicting Adoption of the Nurses Improving Care of Healthsystem Elders Program.

Nurs Res 2019 Jan/Feb;68(1):13-21

Amy Witkoski Stimpfel, PhD, RN, is Assistant Professor, Rory Meyers College of Nursing, New York University, New York. Mattia J. Gilmartin, PhD, RN, FAAN, is Executive Director, NICHE, Rory Meyers College of Nursing, New York University, New York. At the time the research was completed, Dr. Gilmartin was a Senior Research Scientist at Rory Meyers College of Nursing, New York University.

Background: Registered nurses are often underprepared with the knowledge and skills to care for hospitalized older adult patients. One strategy to bridge this gap is for hospitals to adopt the Nurses Improving Care for Healthsystem Elders (NICHE) program: A nurse-led interdisciplinary organizational intervention to improve care of hospitalized older adults.

Objectives: This study aimed to identify the market, organizational and managerial, and sociotechnical factors associated with the adoption of NICHE among U. Read More

View Article
December 2018
1 Read

ACSM PRE-PARTICIPATION HEALTH SCREENING GUIDELINES: A UK UNIVERSITY COHORT PERSPECTIVE.

Med Sci Sports Exerc 2018 Dec 11. Epub 2018 Dec 11.

Carnegie School of Sport, Leeds Beckett University, Leeds, United Kingdom.

Purpose: Pre-participation health screening is recommended to detect individuals susceptible to serious adverse cardiovascular complications during exercise. Although expert opinion and best available scientific evidence have informed recent modifications, there remains limited experimental data to support or refute current practice. We therefore aimed to quantify the impact of change to the ACSM pre-participation health screening guidelines on risk classification and referral for medical clearance in a large cohort of undergraduate university students. Read More

View Article
December 2018

Use of Well-Being in Identification of Members with Future Health Risk Factors and Future Diagnosed Chronic Disease.

J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Research and Advanced Data Science, Sharecare, Inc, 701 Cool Springs Boulevard, Franklin, TN 37067 (Hamar, Jones, Rickles); Concert Genetics, Inc., 810 Crescent Center Drive, Suite 280, Franklin, TN 37067 (Coberley); Tivity Health, 701 Cool Springs Boulevard, Franklin, TN 37067 (Rula).

Objective: To evaluate if well-being is associated with the development of future health risks or incidence of new chronic disease.

Methods: A retrospective cohort study was employed using longitudinal well-being assessment survey data from participants of a Fortune 500 U.S. Read More

View Article
December 2018

Stapled Hemorrhoidectomy Versus Transanal Hemorrhoidal Dearterialization in the Treatment of Hemorrhoids: An Updated Meta-Analysis.

Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.

Department of Anorectal Surgery, First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (TCM), Qinhuai District, Nanjing, Jiangsu Province.

This meta-analysis aimed to compare the clinical outcomes of stapled hemorrhoidectomy (SH) and transanal hemorrhoidal dearterialization (THD) for treating hemorrhoidal disease. Randomized control trials (RCTs) comparing SH with THD were searched in databases, including MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane Library database. Nine RCTs, with 1077 patients, were included in this meta-analysis. Read More

View Article
December 2018

Systematic review addressing nurse practitioner reimbursement policy: Part one of a four-part series on critical topics identified by the 2015 nurse practitioner research agenda.

J Am Assoc Nurse Pract 2018 Dec;30(12):673-682

PediatriCare of Northern Virginia, Haymarket, Virginia George Mason University/Mason and Partners Clinics, Fairfax, Virginia.

Background And Purpose: The growth and sustainability of nurse practitioners (NPs) requires transparent, fair and equitable reimbursement policies. Complicating this issue is variation in reimbursement policy within and across federal, state, and other payers. Even with explicit regulations, there remain questions on how reimbursement policies are covertly operationalized in practice. Read More

View Article
December 2018

Academic nursing scholarship redefined.

Authors:
Tonja M Hartjes

J Am Assoc Nurse Pract 2018 Dec;30(12):664-666

College of Nursing, University of Florida, Gainesville, Florida.

The American Association of Colleges of Nursing (AACN) last defined academic nursing scholarship in 1999. The AACN recognized faculty scholarship must align with the increasingly complex and dynamic health care environment to prepare nurses for an ever-changing future. The new, broader definition recognizes multiple ways of knowing and values all scholarly contributions, which affect nursing science and the health care system. Read More

View Article
December 2018

Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics.

Pain 2018 Oct 17. Epub 2018 Oct 17.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Although self-report pain ratings are the gold standard in clinical pain assessment, they are inherently subjective in nature and significantly influenced by multidimensional contextual variables. Although objective biomarkers for pain could substantially aid pain diagnosis and development of novel therapies, reliable markers for clinical pain have been elusive. In this study, individualized physical maneuvers were used to exacerbate clinical pain in patients with chronic low back pain (N = 53), thereby experimentally producing lower and higher pain states. Read More

View Article
October 2018
1 Read

Narcolepsy, Anesthesia, and Sedation: A Survey of the Perioperative Experience of Patients With Narcolepsy.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Cleveland, Ohio.

Background: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications.

Methods: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network. Read More

View Article
December 2018

Development and Usability Testing of the Society for Pediatric Anesthesia Pedi Crisis Mobile Application.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

United States National Aeronautics and Space Administration, Ames Research Center, Moffett Field, California.

When life-threatening, critical events occur in the operating room, the fast-paced, high-distraction atmosphere often leaves little time to think or deliberate about management options. Success depends on applying a team approach to quickly implement well-rehearsed, systematic, evidence-based assessment and treatment protocols. Mobile devices offer resources for readily accessible, easily updatable information that can be invaluable during perioperative critical events. Read More

View Article
December 2018

Correlation Between IL-20 and De Quervain's Disease Severity.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S6-S12

Department of Orthopedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

De Quervain's disease is a stenosing tenosynovitis of the first dorsal compartment of the wrist. Histopathological studies have reported that the thickening of the first dorsal retinaculum is characterized by degeneration rather than inflammation. However, significant infiltration of mast cells and macrophages was noted in a torn tendon study, which suggested that innate immune pathways are part of the mechanism that mediates early tendinopathy. Read More

View Article
January 2019

Circulating tumor cells in metastatic breast cancer: clinical relevance and biological potential.

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Department of Gynecology and Obstetrics, Düsseldorf University Hospital, Düsseldorf, Germany.

Purpose Of Review: The possibility of tumor dissemination through the blood system has been known for years. Circulating tumor cells (CTCs) are detectable in the peripheral blood of patients with early as well as metastatic breast cancer. The prognostic relevance of this biomarker has already been described. Read More

View Article
December 2018

Co-infection organises epidemiological networks of viruses and hosts and reveals hubs of transmission.

Phytopathology 2018 Dec 12. Epub 2018 Dec 12.

Universidad Politecnica de Madrid, Centro de Biotecnología y Genómica de Plantas, Madrid, Madrid, Spain ;

Multiple virus infections affect the competence of host plants to transmit disease. The effects of co-infection on transmission are expected to produce ecologically complex pathogen and host-pathogen interactions. However, the prediction of disease risk will rely on untangling non-random from random patterns of infection to identify underlying processes that drive these interactions. Read More

View Article
December 2018

Ethnic, gender, and seasonal difference in heavy drinking and protective behavioral strategies among student-athletes.

J Ethn Subst Abuse 2018 Dec 12:1-18. Epub 2018 Dec 12.

c University of North Carolina Greensboro , Greensboro , North Carolina.

Relations among gender, ethnicity, athlete seasonal status, alcohol consumption, and protective behavioral strategies were examined among student-athletes. The national sample (N = 670, M = 18.90) included Black (n = 199), Hispanic (n = 236), and White (n = 235) college student-athletes who use alcohol. Read More

View Article
December 2018

Physiotherapy practice patterns in gait rehabilitation for adults with acquired brain injury.

Brain Inj 2018 Dec 12:1-16. Epub 2018 Dec 12.

a Department of Physical Therapy , University of Toronto , Toronto , Canada.

Objective: Gait dysfunction is common following acquired brain injury (ABI). Clinical practice guidelines can improve patient outcomes; however, information regarding ABI-specific management of gait dysfunction is limited. This study aimed to describe practice patterns of Canadian physiotherapists regarding gait rehabilitation in adults post-ABI. Read More

View Article
December 2018

Quantifying the Urban Food-Energy-Water (FEW) Nexus: The Case of the Detroit Metropolitan Area.

Environ Sci Technol 2018 Dec 12. Epub 2018 Dec 12.

The efficient provision of food, energy, and water (FEW) resources to cities is challenging around the world. Because of the complex interdependence of urban FEW systems, changing components of one system may lead to ripple effects on other systems. However, the inputs, intersectoral flows, stocks, and outputs of these FEW resources from the perspective of an integrated urban FEW system have not been synthetically characterized. Read More

View Article
December 2018
1 Read

Designing spatially distributed gene regulatory networks to elicit contrasting patterns.

ACS Synth Biol 2018 Dec 12. Epub 2018 Dec 12.

Pattern formation and differential interactions are important for microbial consortia to divide labor and perform complex functions. To obtain further insight into such interactions, we present a computational method for simulating physically separated microbial colonies each implementing different gene regulatory networks. We validate our theory by experimentally demonstrating control over gene expression patterns in a diffusion-mediated lateral inhibition circuit. Read More

View Article
December 2018

Less is more: towards a genome-reduced Bacillus cell factory for 'difficult proteins'.

ACS Synth Biol 2018 Dec 12. Epub 2018 Dec 12.

The availability of complete genome sequences and the definition of essential gene sets were fundamental in the start of the genome engineering era. In a recent study, redundant and unnecessary genes were systematically deleted from the Gram-positive bacterium Bacillus subtilis, an industrial production host of high-value secreted proteins. This culminated in strain PG10, which lacks about 36% of the genome, thus representing the most minimal Bacillus chassis currently available. Read More

View Article
December 2018

Performance of Future Elite Players at the National Football League Scouting Combine.

Authors:
David P Hedlund

J Strength Cond Res 2018 Nov;32(11):3112-3118

Division of Sport Management, College of Professional Studies, St. John's University, New York, New York.

Hedlund, DP. Performance of future elite players at the NFL scouting combine. J Strength Cond Res 32(11): 3112-3118, 2018-The purpose of this study is to examine players' physical and performance measures taken at the National Football League (NFL) Scouting Combine and compare these with their future performance in the NFL. Read More

View Article
November 2018
1 Read

Regulation of Ribosome Biogenesis in Skeletal Muscle Hypertrophy.

Physiology (Bethesda) 2019 Jan;34(1):30-42

The Center for Muscle Biology, College of Health Sciences, University of Kentucky , Lexington, Kentucky.

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Read More

View Article
January 2019

High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions.

Physiology (Bethesda) 2019 Jan;34(1):56-70

Department of Diabetes, Central Clinical School, Monash University , Melbourne , Australia.

It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity exercise to promote mitochondrial biogenesis in humans. The purpose of this review is to examine current controversies in the field and to highlight some important methodological issues that need to be addressed to resolve existing conflicts. Read More

View Article
January 2019

An update on the clinical consequences of polypharmacy in older adults: a narrative review.

Expert Opin Drug Saf 2018 Dec 12:1-12. Epub 2018 Dec 12.

a Aging Research Center, Department of Neurobiology , Care Sciences and Society, Karolinska Institutet & Stockholm University , Stockholm , Sweden.

Introduction: Polypharmacy, the use of multiple medications by one individual, is increasingly common among older adults. Caring for the growing number of older people with complex drug regimens and multimorbidity presents an important challenge in the coming years. Areas covered: This article reviews the international trends in the prevalence of polypharmacy, summarizes the results from previous reviews on polypharmacy and negative health outcomes, and updates a previous review on the clinical consequences of polypharmacy by focusing on studies published after 2013. Read More

View Article
December 2018

[Contributions of master in international health & nutrition policies alumni to African development.]

Sante Publique 2018 July August;30(4):535-544

Objectives: This study aims to analyze how graduates, coming from low income Francophone countries, of the Master in International Health and Nutrition Policies program at the Senghor University are a new human capital bringing an original contribution to the global development of African communities.

Methods: A secondary analysis of qualitative findings responded to the research question about the evidences of the impact of this new human capital over the community development of countries where the graduates worked. Findings also revealed graduates' potential to contribute to future endeavors in global health. Read More

View Article
December 2018
1 Read

THE EFFICACY OF THE DIFFERENT ENDOSCOPIC TREATMENTS VERSUS SHAM, PHARMACOLOGIC OR SURGICAL METHODS FOR CHRONIC GASTROESOPHAGEAL REFLUX DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):296-305

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Endoscopia Avançada Gastrointestinal, São Paulo, SP, Brasil.

Background: Endoscopic antireflux treatments for gastroesophageal reflux disease (GERD) are still evolving, and most of the published studies address symptom relief in the short-term. Objective - We aimed to perform a systematic review and meta-analysis focused on evaluating the efficacy of the different endoscopic procedures.

Methods: Search was restricted to randomized controlled trials (RCTs) on MedLine, Cochrane, SciELO, and EMBASE for patients with chronic GERD (>6 months), over 18 years old and available follow up of at least 3 months. Read More

View Article

Role-playing: teaching strategy that encourages reflections on nursing care.

Rev Bras Enferm 2018 ;71(suppl 6):2706-2712

Universidade Federal de Santa Catarina. Florianópolis, Santa Catarina, Brazil.

Objective: Describe the reflections of nursing students on nursing care through the use of role-playing.

Method: Qualitative research with descriptive-exploratory approach and documentary base. The data were collected from portfolios of 32 students from an undergraduate course in the Southern Brazil. Read More

View Article
January 2018

No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: Although attentional bias (AB) toward angry faces is well established in patients with anxiety disorders, it is still poorly studied in obsessive-compulsive disorder (OCD). We investigated whether OCD patients present AB toward angry faces, whether AB is related to symptom severity and whether AB scores are associated with specific OCD symptom dimensions.

Method: Forty-eight OCD patients were assessed in clinical evaluations, intelligence testing and a dot-probe AB paradigm that used neutral and angry faces as stimuli. Read More

View Article
December 2018

[Leisure among university students in the healthcare area: a review of the literature].

Cien Saude Colet 2018 Dec;23(12):4221-4229

Faculdade de Medicina, Universidade Estadual Paulista Julio de Mesquita Filho. Rubião Junior s/n, Rubião Junior. 18618-000 Botucatu SP Brasil.

This article set out to analyze studies on leisure activities among university students in the healthcare area. It conducted a search using the following key words: leisure and students, and their corresponding terms in Spanish and English in the Bireme database, which resulted in 32 articles at the end of the review. In the articles analyzed there was a predominance of the following leisure interests: sports, social, intellectual and artistic activities, with a greater number of articles presenting experiences in sports. Read More

View Article
December 2018
  • Page 1 of 14986